LOCUS       BGC0000660              2468 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000660
VERSION     BGC0000660
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:10:25
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1086
                     /codon_start=1
                     /db_xref="GOA:Q9K499"
                     /db_xref="InterPro:IPR005630"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="PDB:3KB9"
                     /db_xref="PDB:3KBK"
                     /db_xref="PDB:3LG5"
                     /db_xref="PDB:3LGK"
                     /db_xref="PDB:4LTV"
                     /db_xref="PDB:4LTZ"
                     /db_xref="PDB:4LUU"
                     /db_xref="PDB:4LXW"
                     /db_xref="PDB:4LZ0"
                     /db_xref="PDB:4LZ3"
                     /db_xref="PDB:4LZC"
                     /gene="SCO5222"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 267.9; E-value: 2.2e-81)"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC7E4.19"
                     /note="SC7E4.19, possible lyase, len: 361 aa; similar to
                     SW:PTLS_STRSQ (EMBL:U05213) Streptomyces sp. pentalenene
                     synthase (EC 4.6.1.5), 336 aa; fasta scores: opt: 254
                     z-score: 317.5 E(): 3.3e-10; 23.8% identity in 311 aa
                     overlap. Contains match to Prosite entry PS00904 Protein
                     prenyltransferases alpha subunit repeat signature and a TTA
                     leucine codon, possible target for bldA regulation"
                     /product="putative lyase"
                     /protein_id="CAB94607.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 4.6e-39,
                     bitscore: 121.5, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFPHGTTATPTAIAVPPSLRLPVIEAAFPRQLHPYWPKLQETT
                     RTWLLEKRLMPADKVEEYADGLCYTDLMAGYYLGAPDEVLQAIADYSAWFFVWDDRHDR
                     DIVHGRAGAWRRLRGLLHTALDSPGDHLHHEDTLVAGFADSVRRLYAFLPATWNARFAR
                     HFHTVIEAYDREFHNRTRGIVPGVEEYLELRRLTFAHWIWTDLLEPSSGCELPDAVRKH
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHHSLTLEEAIGEVRRRVE
                     ECITEFLAVERDALRFADELADGTVRGKELSGAVRANVGNMRNWFSSVYWFHHESGRYM
                     VDSWDDRSTPPYVNNEAAGEK"
     protocluster    1..2468
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[0:1086]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1..1086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..2468
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..2468
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000660"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..2468
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1086
                     /gene="SCO5222"
                     /gene_synonym="SC7E4.19"
     misc_feature    262..291
                     /gene="SCO5222"
                     /gene_synonym="SC7E4.19"
                     /note="PS00904 Protein prenyltransferases alpha subunit
                     repeat signature"
     misc_feature    883..885
                     /gene="none"
                     /note="TTA leucine codon. Possible target for bldA
                     regulation"
     misc_feature    883..885
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            883..885
                     /gene="none"
     gene            1083..2468
                     /gene="SCO5223"
                     /gene_synonym="SC7E4.20"
     CDS             1083..2468
                     /codon_start=1
                     /db_xref="GOA:Q9K498"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002401"
                     /db_xref="PDB:3DBG"
                     /db_xref="PDB:3EL3"
                     /gene="SCO5223"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 457.8; E-value:
                     6.9e-139)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC7E4.20"
                     /note="SC7E4.20, probable cytochrome P450, len: 461 aa;
                     similar to SW:CP51_HUMAN (EMBL:U23942) Homo sapiens
                     cytochrome P450 51 (EC 1.14.14.1) Cyp51, 503 aa; fasta
                     scores: opt: 532 z-score: 587.2 E(): 3.1e-25; 25.7%
                     identity in 447 aa overlap. Contains Pfam match to entry
                     PF00067 p450, Cytochrome P450"
                     /product="putative cytochrome P450"
                     /protein_id="CAB94608.1"
                     /sec_met_domain="p450 (E-value: 6.6e-74, bitscore: 236.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPL
                     AFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGV
                     ATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAV
                     RVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALAD
                     LHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIAS
                     TIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWV
                     LTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYA
                     MKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRP
                     VAR"
     misc_feature    1152..2363
                     /gene="SCO5223"
                     /gene_synonym="SC7E4.20"
                     /note="Pfam match to entry PF00067 p450, Cytochrome P450,
                     score 221.80, E-value 1e-62"
ORIGIN
        1 gtgcatgctt tcccacacgg caccacagcg acaccgaccg cgatcgcagt accgccatcg
       61 ctccgtctcc cggtgatcga ggcggcattt ccccggcaac tgcacccgta ttggccgaag
      121 ctccaggaga caacccggac ctggctgctc gaaaagcggc tcatgccggc ggacaaggtc
      181 gaggaatatg ccgacggtct gtgctacacg gacctcatgg cgggctacta cctgggcgcc
      241 cccgacgagg tcctgcaggc gatagcggac tacagcgcgt ggttcttcgt ctgggacgac
      301 cgtcacgacc gtgacatcgt ccacggccgg gccggtgcct ggcggcgact gcgcggcctg
      361 ctgcacacgg cactggactc acccggggac cacctgcacc acgaggacac gctggtggcc
      421 gggttcgccg acagtgtgcg gcggctctac gccttcctgc cggccacctg gaacgcccgg
      481 ttcgcccggc acttccacac ggtgatcgag gcgtacgacc gtgaattcca caaccgcacg
      541 cgcggaatcg tgcccggcgt ggaggagtac ctcgaactgc gccggctcac gttcgcgcac
      601 tggatctgga ccgacctgct ggagccgagt tcgggctgcg aactccccga cgccgtacgg
      661 aaacacccgg catatcgccg ggcggcgttg ctgagtcagg aattcgccgc ctggtacaac
      721 gacctctgct cactgccaaa ggaaatagcg ggagacgagg tccacaatct tggcatcagt
      781 ctcatcaccc accattcact caccctggaa gaagccatcg gagaagtccg gcgtcgtgtc
      841 gaggaatgca tcacggaatt cctcgccgtc gagcgggacg ccttacggtt cgccgacgaa
      901 ctcgccgacg gaaccgtacg cggaaaggaa ctgagcggcg ccgtgcgggc caacgtcggc
      961 aatatgcgga actggttcag ttccgtctac tggttccacc acgagtccgg ccggtacatg
     1021 gtcgacagct gggacgaccg gtccacgccc ccgtacgtca acaacgaagc ggcaggtgag
     1081 aaatgaccgt cgagtccgtc aaccccgaaa cccgcgcacc cgcggcaccg ggagcaccgg
     1141 agctgcgcga gccgcccgtc gcgggcggtg gcgttccgct gctcggccac ggctggcggc
     1201 tggcccgcga cccgctggcc ttcatgtccc agctgcgcga ccacggcgac gtcgtgcgca
     1261 tcaagctcgg cccgaagacc gtctacgccg tcacgaaccc cgagctgacc ggcgccctcg
     1321 ccctgaaccc cgactaccac atcgccggtc cgctgtggga gtcgctggag ggcctgctcg
     1381 gcaaggaggg cgtggcgacc gccaacggcc cgctccaccg ccgccagcgg cgcaccatcc
     1441 agccggcgtt ccggctcgac gccatccccg cctacgggcc gatcatggag gaggaggcgc
     1501 acgcgctcac cgagcgctgg cagccgggga agaccgtcga cgccacctcg gagtccttcc
     1561 gggtcgccgt gcgcgtcgcg gcccgctgcc tgctgcgcgg gcagtacatg gacgagcggg
     1621 ccgagcggct ctgcgtcgcg ctcgccaccg tcttccgggg catgtaccgg cggatggtgg
     1681 tcccgctcgg gccgctgtac cggctgccgc ttccggccaa ccgccgattc aacgacgcgt
     1741 tggccgatct gcacctgctg gtcgacgaga tcatcgccga gcgccgtgca tccggtcaaa
     1801 agccggacga tttgctcacg gcattgctgg aggcgaagga cgacaatggc gacccgatcg
     1861 gggaacagga gatccacgac caggtggtcg cgatactcac cccgggcagt gaaaccatcg
     1921 cgtccacgat catgtggttg ctccaggcac ttgccgacca tccggaacat gccgaccgca
     1981 tacgcgacga agtcgaagcg gtcaccggcg gacgtcccgt ggcattcgag gacgtccgga
     2041 agctcaggca caccggcaat gtcatcgtgg aggccatgcg tttgcgtccc gccgtatggg
     2101 tattgacccg gcgcgcggtg gccgagagcg aactcggtgg ctatcgcatt ccggccggtg
     2161 cggacatcat ctacagtccg tacgcaatcc aacgcgatcc gaagtcgtac gacgacaacc
     2221 tggagttcga tcccgaccgg tggctaccgg aacgcgcggc gaatgtgccg aaatacgcca
     2281 tgaagccgtt cagcgcgggc aagcggaagt gccccagtga ccacttttcg atggcccagc
     2341 tcacgctgat cacggccgcg ctcgccacga agtaccgctt cgaacaggtg gcgggctcga
     2401 acgacgcggt ccgggtcggc atcacgctgc gtccgcacga cctgctggtc aggcccgtgg
     2461 cgcggtga
//
