BGC0000662: grixazone A biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 4,957,169 - 4,972,074 nt. (total: 14,906 nt).
This entry is originally from NCBI GenBank AP009493.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
Operons
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000662
Short description grixazone A biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
AP009493.1
4957169 - 4972074
via
Compounds
  • grixazone A
Species Streptomyces griseus subsp. griseus NBRC 13350 [taxonomy]
References
Chemical products information
grixazone A Evidence: NMR [4]
Copy SMILES
C18H15N3O6S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SGR_4238
  • BAG21067.1
  • griT
 4957169 - 4958371 (-) putative LuxR-family transcriptional regulator
    copy AA seq
    copy Nt seq
    • SGR_4239
    • BAG21068.1
    • griS
    		 4958513 - 4959136 (+) GriS protein
      copy AA seq
      copy Nt seq
      • SGR_4240
      • BAG21069.1
      • griR
      		 4959179 - 4960102 (+) transcriptional regulator
        copy AA seq
        copy Nt seq
        • SGR_4241
        • BAG21070.1
        • griA
        		 4960332 - 4961711 (+) putative FAD-dependent oxygenase
          copy AA seq
          copy Nt seq
          • SGR_4242
          • BAG21071.1
          • griB
          		 4961820 - 4963172 (+) putative grixazone transporter
            copy AA seq
            copy Nt seq
            • SGR_4243
            • BAG21072.1
            • griC
            		 4963351 - 4964409 (+) arylcarboxylate reductase component
              copy AA seq
              copy Nt seq
              • SGR_4244
              • BAG21073.1
              • griD
              		 4964409 - 4965779 (+) arylcarboxylate reductase component
                copy AA seq
                copy Nt seq
                • SGR_4245
                • BAG21074.1
                • griE
                		 4965832 - 4966221 (+) copper chaperon
                  copy AA seq
                  copy Nt seq
                  • SGR_4246
                  • BAG21075.1
                  • griF
                  		 4966261 - 4967181 (+) ortho-aminophenol oxidase
                    copy AA seq
                    copy Nt seq
                    • SGR_4247
                    • BAG21076.1
                    • griG
                    		 4967311 - 4968669 (+) putative 3,4-AHBA transporter
                      copy AA seq
                      copy Nt seq
                      • SGR_4248
                      • BAG21077.1
                      • griH
                      		 4968644 - 4969834 (-) Conversion of 2-amino-4,5-dihydroxy-6-one-heptanoic acid-7-phosphate to 3-amino-4-hydroxybenzoic acid
                        copy AA seq
                        copy Nt seq
                        • SGR_4249
                        • BAG21078.1
                        • griI
                        		 4969910 - 4970734 (-) aldolase
                          copy AA seq
                          copy Nt seq
                          • SGR_4250
                          • BAG21079.1
                          • griJ
                          		 4970791 - 4972074 (-) putative aspartokinase homologue
                            copy AA seq
                            copy Nt seq
                            Biosynthesis information

                            Biosynthetic paths

                            3-Amino-4-hydroxybenzoic acid
                            Show structure
                            Pathway: GriI > GriH [3]
                            Comment: The product of GriI proposed, but not detected
                            3-amino-4-hydroxybenzaldehyde
                            Show structure
                            Pathway: GriC+GriD [1]
                            Grixazone A
                            Show structure
                            Pathway: GriE+GriF [2]
                            Comment: This is a 4 step path. The product of the first step was identified by mass spectrometry. The product of the second step was determined by MS and NMR. The second step was proposed to be non-enzymatical. The product of the third step was not detected, was only proposed.
                            Operons
                            Genes Evidence
                            griT
                            griR, griS
                            griR
                            griA, griB
                            griG, griE, griC, griF, griD
                            griI, griH, griJ
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-04-24
                            MIBiG v4 annotathon
                            • (ID: BRDSH5WICJIVUPRS7ELUSARQ)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Fix product metadata
                            • (ID: SJG3CBEHSM6A3I74YXLH6GLA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Add publication
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            Similar known gene clusters from MIBiG 4.0
                            Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                            Click on reference genes to show details of similarities to genes within the current region.
                            Click on an accession to open that entry in the MiBIG database.