LOCUS       BGC0000662             14906 bp    DNA     linear   BCT 07-OCT-2016
DEFINITION  Streptomyces griseus subsp. griseus NBRC 13350 DNA, complete genome.
ACCESSION   BGC0000662
VERSION     BGC0000662
KEYWORDS    .
SOURCE      Streptomyces griseus subsp. griseus NBRC 13350
  ORGANISM  Streptomyces griseus subsp. griseus NBRC 13350
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     On or before Apr 8, 2008 this sequence version replaced AB365454.1,
            AB425192.1.
            The complete and fully annotated sequences are also available at
            http://park.itc.u-tokyo.ac.jp/hakko/genome/
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:10:46
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 4957168
            Orig. end    :: 4972074
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1203)
                     /gene="griT"
                     /locus_tag="SGR_4238"
     CDS             complement(1..1203)
                     /codon_start=1
                     /gene="griT"
                     /locus_tag="SGR_4238"
                     /product="putative LuxR-family transcriptional regulator"
                     /protein_id="BAG21067.1"
                     /transl_table=11
                     /translation="MTGSTISRTSVGRAELLSRSAKATDALSMFAEASTQLRRLMPYDA
                     AVWRVTDPVTGMMTAPIRAENLDEGGCAVYWESELFTENVNLFRDLAQASVPVAGLRQT
                     TGDLPARSTLYQTFMRPRGLQDELRAVLRVGGRPQGHISLFRAEGRPAFDDAETQLIAS
                     VLTPLAKQLRSFAEPSPQPLPDAPHGPGLLLFDAGGGLLSVNDDALAYLDTLPEGPAVP
                     SPQGIRVPAWVQATAMKARAVAQERDRGQARARVRNRAGRWLVCHASCLREAGDRLGAS
                     AVVIEPAKTSEIVPLIVDAYELTDRETEVTQFIARGLPTGEIAAQLHLSPHTVRDHIKA
                     VFEKVGVSSRGELVGKLFTEYYAPLAERNMTRVHTGDTTDDAPKQRHHSPIRPGSRAGH
                     C"
     subregion       1..14906
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..14906
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1345..1968
                     /gene="griS"
                     /locus_tag="SGR_4239"
     CDS             1345..1968
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griS"
                     /locus_tag="SGR_4239"
                     /product="GriS protein"
                     /protein_id="BAG21068.1"
                     /transl_table=11
                     /translation="MRIGIIGAGMLGLAVARRAALAGAAVLLADRSIGRARAAAAGATT
                     AGAAGTVVATTVAAALRPEIVVFAIDWPQALELTRLHAGLLAGKAVVDLSVPSRTDPAS
                     SAVRQLVGLAPEVRWVKALTTADAGALRRGSSDGLVVDVFVAADDDRAKVAVVELLDRS
                     GLRAFDAGGLDNAWVLEGMGRLGQEVGERLQLSESWSFKFMPSW"
     gene            2011..2934
                     /gene="griR"
                     /locus_tag="SGR_4240"
     CDS             2011..2934
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griR"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1041:transcriptional regulator, SARP family (Score:
                     295.4; E-value: 1.7e-89)"
                     /gene_kind="regulatory"
                     /locus_tag="SGR_4240"
                     /product="transcriptional regulator"
                     /protein_id="BAG21069.1"
                     /transl_table=11
                     /translation="MSTHHQFSVLGPLVVQGAHGPVRLGGNRQRILLTLLLLEANRVIG
                     VGRLIEAIWREAPPATVRSQLRICVSGLRRLLSAAGVAAEIETHPSGYLIRVPRVHLDL
                     SHFEDLLSRARAEARSASPERAVVLFQQALQLWHGPVGSGLGSELLETVALKVNEDRLS
                     AIEDRIELELALGRHRQVLGELTRHVAENPFQESLCLQLMLALYRSGRTAEALSVYRDT
                     RRRLARELGLEPSEKLRLMERLILDRRPAGEISPGLAPAPPLPVRAGAPGPQDRIALLE
                     REIADLRDAGGPSGTGVPRAAKGRSG"
     gene            3164..4543
                     /gene="griA"
                     /locus_tag="SGR_4241"
     CDS             3164..4543
                     /codon_start=1
                     /gene="griA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 325.1;
                     E-value: 1.8e-98)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SGR_4241"
                     /product="putative FAD-dependent oxygenase"
                     /protein_id="BAG21070.1"
                     /transl_table=11
                     /translation="MIVAGQTGHAGIAESALDGLVARLRGEVFTPRDAGYERELAGFNR
                     IGRHRPDVIVAAQSAGDVSAAVSFAAREALPVAVQATGHGIAASARGGVLVSTRRMNAV
                     AVDPLTRTAHVEAGAQWHQVIAAGAPHGLAPLNGSSPLVGVVGYTLGGGLGPLGRQYGY
                     AADHVTCIEVVTADGSILRVTRDRHPDLFWALRGGKGNFGIVTGLWFGLVPVRRLHGGG
                     IYFPGEQAAQALHTWRQWTATVPEEMTSSVALLRLPDVPDVPEFLRGTFAAHVRIAFTG
                     RAEEGERLVRPLRECGTPLADTVGEMPYTAVADIHQDPVHPLPYHERNIVLRELGSDAM
                     EALLRAAGAGSSCGDLMVEVRHLGGALSRPAEVPNAVGARDGAFTLATLSPPDSPDVVL
                     GAMEPWGTGRRYLNFLAGADTAGSAAECFDPETLGRLARVKAAVDPGNLFRLNHNIAPL
                     P"
     gene            4652..6004
                     /gene="griB"
                     /locus_tag="SGR_4242"
     CDS             4652..6004
                     /codon_start=1
                     /gene="griB"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 156.5; E-value:
                     1.2e-47)"
                     /gene_kind="transport"
                     /locus_tag="SGR_4242"
                     /product="putative grixazone transporter"
                     /protein_id="BAG21071.1"
                     /transl_table=11
                     /translation="MTTHEAASTAAAGTVSPPGARSDGLRYGALFGPVVFGVTAAGVAL
                     PDVASSLDASSTATAWVLTAHALALGVGTALFGRLADTRGVRAALLLGSLALAAGAVIC
                     LVAPNLGVLVAGRFVQAAGSGAMAACAMALTASVPPERRPQVFAGFGATMAIFSASATL
                     AGGVFTEWVTWRIALVLPALSLLVVPLCLAGAPARKNSGRSMDLPGAALLTLTAMSFLV
                     LIQSSALALSTPLVVATAAVLVLSAAGLTWRTRGSDSSFVPRALVTDRVFLKAAVIGIG
                     VYGGLFAAMYAVPQLLVRDHGWSVLSVGVWLLPGAVVGAVLSRLAGRLTAGDHGNRLLA
                     AVSLAFAAALAAALAGSGVLLLILGASLGFSAFSVTQVFTTALMSGHIEPARRGGAMGL
                     LNLTFFVGGGVGSATAGALAKSMSLATALGVVALFPLIAALVAFTLGRRTP"
     gene            6183..7241
                     /gene="griC"
                     /locus_tag="SGR_4243"
     CDS             6183..7241
                     /NRPS_PKS="Domain: AMP-binding (79-301). E-value: 6.2e-12.
                     Score: 36.6. Matches aSDomain:
                     nrpspksdomains_SGR_4243_AMP-binding.1"
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SGR_4243"
                     /product="arylcarboxylate reductase component"
                     /protein_id="BAG21072.1"
                     /sec_met_domain="AMP-binding (E-value: 1e-09, bitscore:
                     27.2, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLIDDPEFDSHVVKLMAWHFGAETGSPFWLGKLAGLGFDPVTDV
                     RGLADLTRFPDVSAELRSVPAQDLIPRGLSDRPFRVYDSGGTTGSPKRIVDSGYRSLVT
                     EWARERLIANGVPADGNWLHLGPGGPHVIGFDTARYAALGGGVFYTVDLDPRWVKRLLS
                     QGRGEESEAYVQHLLDQAETILESQEIAVLNTTPPLLEAICARPRLYELVRSGVRAIIW
                     AGTSISRETLTQLDDVFFPAASVVGVYGNSLMGVAPQRSGRPGDAHRCVFEPYPETTRL
                     HLVDEDGTPVAYGERGRVRLHLVSEEMFLPNVLERDTAIRVEPGEGSTVDGLADVQTYR
                     SLDDVAIIEGVY"
     aSDomain        6420..7085
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SGR_4243_AMP-binding.1"
                     /evalue="6.20E-12"
                     /label="SGR_4243_AMP-binding.1"
                     /locus_tag="SGR_4243"
                     /protein_end="301"
                     /protein_start="79"
                     /score="36.6"
                     /tool="antismash"
                     /translation="RVYDSGGTTGSPKRIVDSGYRSLVTEWARERLIANGVPADGNWLH
                     LGPGGPHVIGFDTARYAALGGGVFYTVDLDPRWVKRLLSQGRGEESEAYVQHLLDQAET
                     ILESQEIAVLNTTPPLLEAICARPRLYELVRSGVRAIIWAGTSISRETLTQLDDVFFPA
                     ASVVGVYGNSLMGVAPQRSGRPGDAHRCVFEPYPETTRLHLVDEDGTPVAYGERGRVRL
                     "
     gene            7241..8611
                     /gene="griD"
                     /locus_tag="SGR_4244"
     CDS             7241..8611
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 55.5; E-value:
                     5.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SGR_4244"
                     /product="arylcarboxylate reductase component"
                     /protein_id="BAG21073.1"
                     /transl_table=11
                     /translation="MSTVAPPAVVLDPRVRGRLVASSDRTRLPSVLGGDLADVGTAPRL
                     LAVAALNEIRAHADGRPPASEVFTEAARLFATATLDGETPREYARRVCHATGLTATAVE
                     QAVTDLTGELRALPATTAAELPATGFGDGFDTRWVPRGRTFAAVMASNHPVPNISWAQA
                     LFHGYSVLVKPGSRDPFTPARLLAALTAAGLPPDRAAFLPCSREVGAYLLREADRGIVY
                     GGDSAVATWHQRESVAVRGPGRTKAFLDRAPDDAVIDHLALSASFDGGTRCTNLSAVLT
                     TGPVEEVADRLAERLARLPSLPATDEAATLLVVNRARADGLREQVAALRASLTDHSARA
                     GDPETVVELPDGSFLPRPVVLSADRADHPAVGTELPFPFVVVAPWAEADGVEPLRDSLV
                     LNLLTDREELVEAAVREPSVRKVTRGPVLPWTATPGIPHDDNYTQFLLEPKGVVARR"
     gene            8664..9053
                     /gene="griE"
                     /locus_tag="SGR_4245"
     CDS             8664..9053
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     melanin: melC"
                     /gene_kind="biosynthetic"
                     /locus_tag="SGR_4245"
                     /product="copper chaperon"
                     /protein_id="BAG21074.1"
                     /sec_met_domain="melC (E-value: 2.4e-35, bitscore: 111.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPMNRREMVMATTGAALAAAAAVPLLSGGEGEGAAEAAAAPAKAT
                     GRGREHTERYLGRSIRVAAPADGGGVFIDGRPLHIMKFADDAYLSSMCHYEMAPTPLHA
                     ARRAVEELRGAALQPSTHGTHVTHL"
     gene            9093..10013
                     /gene="griF"
                     /locus_tag="SGR_4246"
     CDS             9093..10013
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griF"
                     /locus_tag="SGR_4246"
                     /product="ortho-aminophenol oxidase"
                     /protein_id="BAG21075.1"
                     /transl_table=11
                     /translation="MVHVRKNHLTMTAEEKRRFVHAVLEIKRRGIYDRFVKLHIQINST
                     DYLDKETGKRLGHVNPGFLPWHRQYLLKFEQALQKVDPRVTLPYWDWTTDHGENSPLWS
                     DTFMGGNGRPGDRRVMTGPFARRNGWKLNISVIPEGPEDPALNGNYTHDDRDYLVRDFG
                     TLTPDLPTPQELEQTLDLTVYDCPPWNHTSGGTPPYESFRNHLEGYTKFAWEPRLGKLH
                     GAAHVWTGGHMMYIGSPNDPVFFLNHCMIDRCWALWQARHPDVPHYLPTVPTQDVPDLN
                     TPLGPWHTKTPADLLDHTRFYTYDQ"
     gene            10143..11501
                     /gene="griG"
                     /locus_tag="SGR_4247"
     CDS             10143..11501
                     /codon_start=1
                     /gene="griG"
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 269.2; E-value: 1e-81)"
                     /gene_kind="transport"
                     /locus_tag="SGR_4247"
                     /product="putative 3,4-AHBA transporter"
                     /protein_id="BAG21076.1"
                     /transl_table=11
                     /translation="MYAVLALCWLLVFFDGLDVTVYGAVMPYMLDDTAFGLDAAAAGRI
                     GSWTTFGMLIGALAAGTITDWIGRRTVLVWCVLLFSAGSGVCALAGDPLPFGAGRFLAG
                     LGLGGLMPICLTVVAEFAPPRRMALATGVLMTAYHAGGMAATGLGLALAPDHGWRWPFA
                     AGVLPAIIAVPLLLRHLPESPGVLYARGRFEQARLTAERYGLPAPSAADAPAAGASGRL
                     RAVRDLVAPGRALATLLLWAASFCGLLLVYGISTWLPQLMRSAGYGLSTSVALLMVINA
                     GGIVGMPVAGRVADRFGAVRVATCWFLLTAAGLALLATGPSLALTYAVVAFTGIWLFSA
                     STMVYAVAGRFYPAADRAAGLGWVTGVGRLGAVVSPMLGGALVARGLGSGGFLVFALGG
                     VLGAVTVLLVPVVAAARTRTDAGRAAGGEPGDAAGAGREPNSRAETTSPGRTR"
     gene            complement(11476..12666)
                     /gene="griH"
                     /locus_tag="SGR_4248"
     CDS             complement(11476..12666)
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griH"
                     /locus_tag="SGR_4248"
                     /product="3,4-AHBA synthase"
                     /protein_id="BAG21077.1"
                     /transl_table=11
                     /translation="MSSSPSPSPSSSSSSSASSSASSSPSSSSKLTWLDIRSVGEARAA
                     IVQEALHHRVEALVADDPAHLADLPPTVAKVLLVVGKQIPEEFGEATVVVVDPSKHGVT
                     PAELALKHPEIEFGRFVEIIDAPTLEDACESSRTEKWSVLLFRDPTKIPLEIVIAAAAR
                     ASGSMVTIAQDLEEAEILFGVLEHGSDGVMMAPKTVGDAAELKRIAEAGIPNLNLTELR
                     VVETSHIGMGERACVDTTTHFGEDEGILVGSHSKGMILCVSETHPLPYMPTRPFRVNAG
                     AIHSYTLGRDERTNYLSELKTGSKLTAVDIKGNTRLVTVGRVKIETRPLISIDAEAPDG
                     RRVNLILQDDWHVRVLGPGGTVLNSTELKPGDTVLGYLPVEDRHVGYPINEFCLEK"
     gene            complement(12742..13566)
                     /gene="griI"
                     /locus_tag="SGR_4249"
     CDS             complement(12742..13566)
                     /codon_start=1
                     /experiment="gene cloning and expression"
                     /gene="griI"
                     /locus_tag="SGR_4249"
                     /product="aldolase"
                     /protein_id="BAG21078.1"
                     /transl_table=11
                     /translation="MAPNAPFARSLRLQRLHHHDPDRLFIVPLDHSITDGPLSRAHRLD
                     PLVGELASHHVDGIVLHKGSLRHVDPEWFTRTSLIVHLSASTVHAPDPNAKYLVSSVEE
                     SLRMGADAVSVHVNLGSEGERHQIADMAAVAEACDRWNVPLLAMMYPRGPKIDDPRDPA
                     LVAHAVQVAVDLGADLVKTLYVGSVAAMAEITAASPVPVVVVGGPRDSDESRILAYVDD
                     ALRGGAAGVAMGRNVFQAPDPGAMADKLSDLIHNSGTRGAARAPAGAAAGAA"
     gene            complement(13623..14906)
                     /gene="griJ"
                     /locus_tag="SGR_4250"
     CDS             complement(13623..14906)
                     /codon_start=1
                     /gene="griJ"
                     /locus_tag="SGR_4250"
                     /product="putative aspartokinase homologue"
                     /protein_id="BAG21079.1"
                     /transl_table=11
                     /translation="MTTQGSRPTGDVVVQKYGGSSLATVSQVRQVADRVGALARSGRRV
                     VVVVSAQGDTTDELVGRAEAVNPRPAGHELDQLLATGETASAALMAMALQRGGLAATAL
                     SGARSGVLATGPHGAGVIVAVDTDQLRTLLDAGRTVVLAGFQGVTAEGDIITLGRGGSD
                     TTAVAVAAELRSGHCEIYSDVPGVFTADPRVVPDARLMPDIDIDVMTEMAFAGARVMHA
                     RAVELAALYDVDILVGRSTATRTGTRIHRRDGNDMLEDRTAVSAVVHDADIARITLRTH
                     DTPDPSADVFRFLAKESIPADMTTVSSAPDGGFSLGFTVRRSHAADVGRSFSDLMAPRP
                     HGVEVEDQVAKVSIVGQGLLSRPEYASRMLASLVGSGISARSLTASQLRVSVTVPRSDA
                     VRAVGLLHSEFGLGAEAGAVPASLTPRP"
ORIGIN
        1 tcagcagtgc cccgcacgcg acccggggcg aatgggggag tggtgtcgct gcttcggtgc
       61 gtcgtccgtc gtgtcgccgg tgtggacccg cgtcatgttc cgctccgcga gcggcgcgta
      121 gtactcggtg aacagtttgc ccaccagctc accgcggctg gagaccccga ccttctcgaa
      181 gaccgccttg atgtggtccc ggaccgtgtg cggggagagg tgcagctgtg ccgcgatctc
      241 cccggtcggg aggccgcggg cgatgaactg ggtgacctcg gtctcccggt cggtgagttc
      301 gtacgcgtcc acgatcagcg ggacgatctc cgaggtcttc gcgggctcga tcaccaccgc
      361 ggaggcgccg agccggtcgc ccgcctcccg caggcaggag gcgtggcaga ccagccagcg
      421 gccggcccgg ttccgtacgc gcgcacgcgc ctggccgcgg tcgcgctcct gcgcgacggc
      481 ccgggccttc atcgcggtcg cctggaccca ggccggcacc cggatgccct ggggcgaggg
      541 cacggcgggg ccttcgggca gggtgtcgag ataagcgagg gcgtcgtcgt tgaccgacag
      601 cagcccgccg cccgcgtcga acaggaggag accggggccg tgcggggcgt ccggcagcgg
      661 ctgcggggag ggctcggcga acgagcgcag ctgcttggcg agcggcgtga ggacggaggc
      721 gatcagctgg gtctcggcgt cgtcgaaggc cgggcgcccc tcggcccgga acaggctgat
      781 gtggccctgg gggcggcccc ccacgcgcag gaccgcgcgc agttcgtcct ggagtccgcg
      841 aggacgcatg aaggtctggt agagcgtgct gcgcgcgggc aggtcaccgg tggtctgccg
      901 gagcccggcg accgggaccg aggcctgcgc cagatcccgg aacaggttga cgttctcggt
      961 gaacagctcg gattcccagt agacggcgca gccgccctcg tccaggttct ccgcgcggat
     1021 cggcgcggtc atcatgccgg tcaccgggtc ggtgacccgc cacaccgccg cgtcgtacgg
     1081 catgagccgg cgcagttgcg tcgaggcctc ggcgaacatg ctgagcgcgt cggtggcctt
     1141 cgcggaccgg gagagcagtt ccgcccggcc taccgaggtg cgcgagatcg tcgaaccggt
     1201 catcccccga ctgtgacagt cccgtcgtcc cgctccaacc ccctgtctga ggggggcggt
     1261 tctttcgcgc cgttcctccg gggagcgccg ccccccttga ttgcgggatg ggaaccgcgc
     1321 ccgtatcccg caagtgtgcc gttcatgcgg attgggatta tcggagcggg aatgttgggg
     1381 cttgcggtcg cccggcgggc ggcgctggcg ggcgccgcgg tgctgctggc ggaccggagc
     1441 atcggacggg cccgagccgc ggcggccggg gcgacgacgg cgggggcggc cggaaccgtg
     1501 gtggccacca cggtggccgc cgcgctccgg ccggagatcg tggtcttcgc gatcgactgg
     1561 ccccaggccc tggagctgac ccggctgcac gccggtctgc tggccggcaa ggcggtcgtg
     1621 gacctgagcg ttccctcgcg gaccgacccg gcgtcgagcg cggtccgcca actggtcggt
     1681 ctcgccccgg aggtgcggtg ggtcaaggcg ctgaccaccg ccgacgccgg tgccctgcgc
     1741 cggggttcca gcgacgggct cgtggtggac gtgttcgtcg cggccgatga cgaccgcgcc
     1801 aaggtggccg tcgtggagct gctcgaccgg tcggggctgc gcgccttcga cgccggtggc
     1861 ctggacaacg cctgggtgct ggaaggcatg gggcggctgg ggcaggaggt gggagagcgg
     1921 ctgcagctca gcgagagctg gagcttcaag ttcatgccca gctggtgatc tcccggacat
     1981 cgcggttgag tttcaggaag gcgttcacac atgtctacgc accatcaatt ctccgtactg
     2041 ggtccactcg tcgtccaagg cgcgcacggt cccgtgcgcc tcggcggaaa tcggcagcgg
     2101 atcctgctga ccctgctgct cctggaagcg aaccgggtga tcggcgtggg ccggctgatc
     2161 gaggcgatct ggagagaggc gcccccggcg acggtccgca gccagctgcg gatctgcgtg
     2221 tccggcctcc gaagactcct ctcggccgcg ggtgtcgcgg ccgagataga gacgcacccg
     2281 tcgggctacc tgatccgggt gccgcgggtg catctcgacc tgtcccactt cgaggatctg
     2341 ctcagccggg cgcgggcgga ggcgcgctcg gcgtcaccgg aacgcgcggt cgtgctgttc
     2401 cagcaggcgc tccagctctg gcacgggccg gtggggtccg ggctggggag cgagctcctg
     2461 gagaccgtgg ccctgaaggt gaacgaggac cggctgtccg cgatcgagga ccgcatcgag
     2521 ctcgaactcg cgctgggccg gcaccgccag gtgctgggcg agctgacccg gcacgtggcg
     2581 gagaacccgt tccaggagtc gctgtgcctc cagctgatgc tggcgctgta ccggtccggc
     2641 cggaccgccg aggcgctgtc ggtctaccgg gacacgcgcc ggaggctggc gcgggagctg
     2701 ggtctcgaac cgagcgagaa gctgcgcctg atggagcggc tgatcctgga ccggcgcccg
     2761 gcgggagaga tctcgccggg cctcgccccg gcgccgccgc tgcccgtgcg ggccggcgct
     2821 ccggggccgc aggaccggat cgccctgctg gagcgggaga tcgcggacct gcgggacgcg
     2881 ggcgggccgt ccggcacggg cgtgccgcgt gcggcgaaag ggcgctccgg ctgaccggcg
     2941 tccgccatcg cgtgcccgcg cgctccgggg gccgggcccg gccccggacc cggtggaggc
     3001 cgcggcccgg tggagggccg aggtccctcc ccgccccgat ggagggacgg ggcgtctccc
     3061 atccccccta agcaggggat gggagacgcc ccgccggacg agaacactgc tcctcatcgc
     3121 cgccgcgcct tgcgggaccg ccgcgcggca cgggaggaag gacatgatcg tggcaggaca
     3181 gaccggacac gcgggcatcg ccgagagcgc tctggacggg ctcgtcgcac ggctcagggg
     3241 cgaggtcttc actccgcgcg acgcggggta cgagagggag ctcgcggggt tcaaccggat
     3301 cgggcggcac cggcccgatg tgatcgtcgc cgcccagtcg gccggggacg tgtccgccgc
     3361 ggtctccttc gccgcccggg aggcgctccc ggtcgccgtc caggcgaccg gccacggcat
     3421 cgcggcgtcc gcgcgcggcg gtgtcctcgt ctccacccgc cggatgaacg cggtcgccgt
     3481 cgacccgctc acccgtacgg cgcacgtgga ggccggagca cagtggcacc aggtgatcgc
     3541 cgcgggtgcg ccgcacggtc tggcgccgct caacgggtcg tcgccgctgg tcggcgtggt
     3601 gggctacacg ctgggcggcg ggctcggccc gctgggccgc cagtacgggt acgcggcgga
     3661 ccacgtgacc tgtatcgagg tcgtcaccgc cgacggaagc atcctgcggg tcacccgcga
     3721 ccggcatccg gacctgttct gggcgctgcg cggcggcaag gggaacttcg gcatcgtcac
     3781 cggcctgtgg ttcggactgg tgccggtgcg ccggctccac ggcggcggga tctacttccc
     3841 cggtgagcag gcggcgcagg ccctgcacac ctggcggcag tggaccgcga ccgttcccga
     3901 ggagatgacc tcctccgtgg cgctgctgcg gctgccggac gtgccggacg tgccggagtt
     3961 cctccgcggg acgttcgccg cgcatgtgcg gatcgcgttc accggccggg ccgaggaggg
     4021 ggagcggctc gtccgtccgc tgcgcgagtg cggtacgccg ctggcggaca cggtcggcga
     4081 gatgccgtac accgcggtgg ccgacatcca ccaggatccg gtgcatcccc tgccctacca
     4141 cgaacgcaac atcgtgttgc gggagttggg ctccgacgcc atggaggcgc tgctgcgggc
     4201 ggccggggcc ggttcgtcgt gcggcgatct gatggtcgag gtgcggcacc tgggcggtgc
     4261 gctctcccgg cccgccgagg tgcccaacgc ggtcggcgcc cgcgacggcg cgttcaccct
     4321 cgcgacgctc tcgcccccgg actcgccgga cgtggtcctc ggggcgatgg agccctgggg
     4381 cacgggccgc cgctatctga acttcctcgc gggcgcggac acggcgggct cggcggcgga
     4441 gtgcttcgac ccggagaccc tcggccggct ggcgcgcgtg aaggccgcgg tcgaccccgg
     4501 caacctcttc cggctcaacc acaacatcgc gccccttccg tagggcgggc gccctttgcc
     4561 cgcccgtatc gacgagcggc ccccgtgggc gtcctgccga ccggagccgc tcgtcatttg
     4621 gcaggtactc gtcaagattg ggagtccatt catgaccacg cacgaggccg cttcgaccgc
     4681 ggccgccggc accgtctccc ctccgggagc ccgctcggac gggctgcgct acggcgccct
     4741 gttcggcccg gtcgtcttcg gcgtcaccgc cgccggagtg gccctgcccg acgtggcgtc
     4801 ctcgctcgac gcctcctcca ccgccacggc ctgggtcctg acggcccacg cgctcgccct
     4861 cggcgtcggc accgcgctgt tcggccgcct cgccgacacc cgcggcgtcc gcgccgccct
     4921 gctgctcggc tcgctggccc tcgcggccgg cgccgtcatc tgcctcgtcg cgcccaacct
     4981 cggcgtcctg gtggccgggc gcttcgtcca ggccgccggc tccggcgcca tggcggcctg
     5041 cgccatggcg ctcaccgcct cggtgccgcc ggagaggcgg ccgcaggtct tcgccggatt
     5101 cggggcgacg atggccatct tctccgccag cgccaccctg gcgggcggcg tcttcaccga
     5161 gtgggtcacc tggcgcatcg ccctggtcct gcccgcgctc tccctgctcg tcgtcccgct
     5221 gtgcctggcc ggggcgcccg cgcgcaagaa ctccggccgc tcgatggacc tgccaggcgc
     5281 cgccctgctg acgctcaccg ccatgtcgtt cctcgtgctg atccagtcct ccgccctcgc
     5341 gctgagcacc ccgctggtgg tcgccaccgc cgccgtactc gtcctgtcgg ccgccgggct
     5401 cacctggcgc acccgcggca gcgactcctc cttcgtgccc cgcgccctcg tcaccgaccg
     5461 cgtgttcctg aaggccgccg tgatcggcat cggcgtgtac ggcggcctgt tcgccgcgat
     5521 gtacgccgtc ccgcagctcc tcgtccgcga ccacggctgg agcgtcctgt cggtcggcgt
     5581 ctggctgctg cccggcgcgg tcgtcggcgc ggtcctctcc aggctggccg gccggctcac
     5641 cgcgggcgac cacggcaacc ggctcctcgc cgccgtctcg ctcgccttcg ccgcggcgct
     5701 ggccgcggcc ctcgccggct ccggcgtgct gctgctgatc ctcggcgcct cgctcggctt
     5761 ctccgcgttc tccgtcaccc aggtcttcac caccgcgctg atgtcgggac acatcgaacc
     5821 ggcccggcgc ggcggggcga tggggctgct caacctcacg ttcttcgtcg gcggcggcgt
     5881 cggcagcgcc accgcgggcg ccctggcgaa gtcgatgtcg ctcgccacgg cgctcggcgt
     5941 ggtcgccctc ttcccgctga tcgccgccct ggtcgccttc accctggggc ggcgcacccc
     6001 ctgaccgcgg cgggaccccg accgcccgca cggcgccgct tccgggcgcc gtgcgggcgg
     6061 aagcgttccc cgacccgcgg acacgtttca cgacacccgg gcgatacgtg gccgataggc
     6121 cccgcccgca cgatgggtgc cgtaccgccc ttgccccgtg atcaggagag cggaagaccg
     6181 acatgagcct catcgatgat cccgaattcg acagtcacgt agtgaagttg atggcctggc
     6241 acttcggtgc cgagaccggc tcgccgttct ggctgggaaa gctggccggg ctcggtttcg
     6301 atcccgtcac cgacgtccgg ggcctggccg acctgacccg cttcccggac gtcagcgccg
     6361 aactccgctc cgtaccggcc caggacctga tcccccgagg actgtccgac cgccccttcc
     6421 gggtctacga ctcgggcggc accaccggat cgcccaagcg catcgtggac agcggctacc
     6481 ggtcgctggt gaccgagtgg gcgcgggaga ggctgatcgc gaacggcgtc cccgcggacg
     6541 gcaactggct gcacctgggg cccggcggcc cgcacgtcat cggattcgac acggcccgct
     6601 acgccgcgct cggcggcggc gtcttctaca ccgtcgacct cgacccgcgc tgggtgaagc
     6661 ggctcctgtc gcaggggcgc ggcgaggagt ccgaagcgta cgtccagcac ctgctggacc
     6721 aggcggagac catcctggag agccaggaga tcgcggtgct caacaccacc ccgccgctcc
     6781 tggaggcgat ctgcgccaga ccgcgcctgt acgagctggt gcgctccggg gtccgcgcga
     6841 tcatctgggc cggaacgtcc atcagccggg agaccctcac ccagctcgac gacgtcttct
     6901 tcccggcggc gagcgtggtc ggcgtctacg gcaacagcct gatgggcgtg gccccgcaac
     6961 ggtcgggccg gcccggcgac gcccaccgct gcgtcttcga gccgtacccc gagaccacgc
     7021 gcctccacct cgtggacgag gacggcacgc cggtggcgta cggcgaacgc ggccgggtcc
     7081 ggctccacct ggtctcggag gagatgttcc tgcccaacgt cctggaacgg gacaccgcga
     7141 tccgtgtcga gcccggggaa ggctcgaccg tggacggcct cgccgacgtg cagacctacc
     7201 gcagcctcga cgacgtggcc atcatcgagg gggtctactg atgagcaccg tcgcaccccc
     7261 cgccgtcgtc ctcgatccgc gcgtccgcgg tcgcctggtc gccagctccg accgcacccg
     7321 gctgccgagc gtcctcggcg gcgacctcgc cgacgtcggg accgcgcccc ggctcctcgc
     7381 ggtcgccgcg ctgaacgaga tccgcgcaca cgcggacggc agaccgcccg cctccgaggt
     7441 gttcaccgaa gcggcccggc tgttcgccac cgcgacactg gacggggaga ccccgcggga
     7501 gtacgcgagg cgggtctgcc acgccaccgg cctcaccgcc accgccgtcg agcaggccgt
     7561 caccgacctg accggcgaac tgcgcgccct cccggcgacc accgccgccg aactgccggc
     7621 caccggcttc ggcgacggct tcgacacccg ctgggtgccg cgcggaagga ccttcgccgc
     7681 ggtgatggcg agcaaccacc cggtgcccaa catctcctgg gcgcaggccc tgttccacgg
     7741 ctacagcgtg ctcgtcaagc cgggcagccg cgacccgttc accccggccc ggctgctcgc
     7801 cgcactgacc gcggcgggcc tgccgcccga ccgggccgcg ttcctgccgt gctcgcgcga
     7861 ggtcggcgca tacctgctgc gggaggccga ccggggcatc gtctacggcg gtgacagcgc
     7921 cgtcgccacc tggcaccagc gggaatcggt ggcggtccgg ggacccggcc ggaccaaagc
     7981 gttcctggac cgggccccgg acgacgccgt catcgaccac ctggcgctct ccgcctcctt
     8041 cgacggcggc acccgctgca ccaacctctc ggccgtcctg accaccggac cggtcgagga
     8101 ggtcgccgac cggctcgcgg agcggctcgc gcggctgccc tcgctgccgg ccaccgacga
     8161 agcggcgacg ctcctggtgg tgaaccgggc ccgcgccgac gggctgcgcg aacaggtcgc
     8221 cgccctccgc gcctcgctca ccgaccacag cgcccgcgcc ggggatccgg agaccgtcgt
     8281 ggagctgccc gacggctcgt tcctgccgcg gccggtcgtc ctctccgccg accgcgccga
     8341 ccatccggcg gtcggcacgg aactgccctt cccgttcgtc gtggtggccc cgtgggcgga
     8401 ggccgacggc gtggagccgc tccgcgactc cctcgtcctc aacctgctca ccgaccgcga
     8461 ggaactggtc gaggccgccg tacgggagcc gagcgtccgc aaggtgacgc gcgggccggt
     8521 cctgccctgg accgccaccc ccggaatccc gcacgacgac aactacacgc agttcctgct
     8581 ggagcccaag ggcgtcgtgg cccggcgctg acccctcccg cccaccctcc gcaccgcacg
     8641 acaccgtcag aaaggcagtc cgcatgccca tgaacaggcg agaaatggtc atggccacca
     8701 ccggggcggc gctcgccgcc gcggccgccg tccccctgct gagcggcggc gaaggcgagg
     8761 gagccgccga ggccgccgcc gcaccggcga aggccaccgg ccggggccgg gagcacaccg
     8821 agcgctatct cggccggtcc atacgggtcg ccgctccggc ggacggcggc ggtgtgttca
     8881 tcgacggccg gccgctccac atcatgaagt tcgccgacga cgcctacctc agctccatgt
     8941 gccactacga gatggccccc accccgctgc acgcggcccg gcgcgccgtc gaggaactgc
     9001 gcggcgccgc actccagccc tccacgcacg gcacccacgt cacgcacctc tgacccctcc
     9061 ggaaccggcc ccgcagcgaa ggaaacccag cgatggtcca cgtacgcaag aaccacctca
     9121 ccatgacggc cgaggagaaa cgccggttcg tccacgcggt cctggagatc aagaggcgcg
     9181 gcatctacga ccggttcgtc aagctccaca tacagatcaa ctccacggac tacctcgaca
     9241 aggagaccgg caagcgcctc ggccacgtca acccggggtt cctgccgtgg caccgccagt
     9301 acctgctgaa gttcgaacag gccctccaga aggtcgaccc gcgcgtcacc ctgccctact
     9361 gggactggac caccgaccac ggcgagaact caccgctctg gtccgacacg ttcatgggag
     9421 gcaacggccg gcccggcgac cgccgcgtca tgaccgggcc cttcgcccgc cgcaacggct
     9481 ggaagctcaa catcagcgtc atcccggaag gccccgagga tccggccctg aacggcaact
     9541 acacccacga cgaccgcgac tacctcgtac gggacttcgg cacgctcacc ccggacctgc
     9601 cgaccccgca ggagctggag cagaccctcg acctcaccgt ctacgactgc ccgccgtgga
     9661 accacacctc cggcggcacc ccgccgtacg agagcttccg caaccacctg gagggctaca
     9721 ccaagttcgc ctgggagccg aggctcggca agctgcacgg cgccgcgcac gtgtggaccg
     9781 gcggccacat gatgtacatc ggctcgccga acgacccggt gttcttcctc aaccactgca
     9841 tgatcgaccg ctgctgggcc ctgtggcagg cacgccaccc ggacgtgccc cactacctgc
     9901 cgaccgtgcc gacccaggac gtgcccgacc tcaacacccc gctcggaccc tggcacacca
     9961 agacgcccgc ggacctgctc gaccacacgc ggttctacac ctacgaccag tagccccccg
    10021 cgccccgcac ccacgcggcg gcgccggaca gcggatcacc gctgcccggc gccgccgcgt
    10081 tctggtaccc accgcgcctt caccgccccg cacctccacc gcaacgaacc gggagagaca
    10141 ccgtgtacgc agtactcgcc ctgtgctggc tcctcgtctt cttcgacgga ctggacgtca
    10201 cggtctacgg cgccgtcatg ccgtacatgc tcgacgacac cgcctttggc ctcgacgccg
    10261 cggcggccgg ccggatcggc agctggacca ccttcggcat gctcatcggc gcgctcgccg
    10321 ccggcaccat cacggactgg atcggcagac gcaccgtcct ggtctggtgc gtgctcctgt
    10381 tctccgccgg ctccggcgtc tgcgcgctgg ccggtgaccc gctcccgttc ggagccggcc
    10441 ggttcctggc cggcctcggc ctcggcggcc tgatgccgat ctgcctgacc gtggtggcgg
    10501 agttcgcacc gccgcggcgg atggccctgg ccaccggagt gctgatgacc gcctaccacg
    10561 cgggcggcat ggcggcgacg ggcctcggcc tcgcactcgc cccggaccac ggctggcggt
    10621 ggcccttcgc ggcgggcgtg ctgcccgcga tcatcgccgt acccctgctg ctgcgccacc
    10681 tgccggagtc gccgggcgtg ctctacgccc gcggccggtt cgagcaggcg cgcctgaccg
    10741 ccgaacggta cggacttccc gcgccgtccg ccgcggacgc gccggccgcc ggggcctcgg
    10801 gccggctgcg cgcggtccgc gacctcgtgg cgcccggccg cgccctggcc acgctgctgc
    10861 tgtgggccgc ctccttctgc gggctgctgc tcgtgtacgg catctccacc tggctgccgc
    10921 agctgatgcg ctccgccggc tacggcctgt cgacctcggt cgccctgctc atggtcatca
    10981 acgcgggcgg catcgtcggc atgccggtcg ccggacgggt ggccgaccgg ttcggcgccg
    11041 tccgcgtcgc gacctgctgg ttcctgctga cggcggccgg gctggccctg ctggccaccg
    11101 gcccctcgct ggccctcacc tacgcggtcg tcgccttcac cggcatctgg ctgttcagcg
    11161 ccagcaccat ggtctacgcg gtcgccgggc gcttctaccc cgccgccgac cgcgccgcgg
    11221 gcctgggctg ggtcaccggg gtgggacggc tcggcgcggt ggtcagtccg atgctcggcg
    11281 gcgcgctcgt cgcccgcggg ctgggaagcg gggggttcct ggtcttcgcc ctcggcggcg
    11341 tcctcggcgc cgtcaccgtg ctcctggtgc ccgtcgtcgc ggcggcccgc acgcgcacgg
    11401 acgccggccg cgccgccggg ggagaaccgg gcgacgcggc cggggccggg cgggagccga
    11461 actcccgggc ggagactact tctccaggca gaactcgttg atcgggtagc cgacgtgacg
    11521 gtcctcgacg ggcaggtagc cgaggaccgt gtcgccgggc ttcagctcgg tgctgttgag
    11581 gaccgtgcca ccggggccga ggacccggac gtgccagtcg tcctggagga tcaggttgac
    11641 gcgccggccg tccggggcct cggcgtcgat ggagatcagc gggcgggtct cgatcttcac
    11701 gcggcccacg gtcaccagcc gggtgttgcc cttgatgtcg acggcggtga gcttgctgcc
    11761 cgtcttcagt tcgctcaggt agttcgtgcg ctcgtccctg cccagcgtgt acgagtggat
    11821 ggcgccggcg ttgacgcgga acggccgggt cggcatgtac ggcagcgggt gggtctcgct
    11881 gacgcagagg atcatgccct tggagtgcga gccgaccagg atgccctcgt cctcgccgaa
    11941 atgcgtggtg gtgtccacgc aggcccgctc gcccatgccg atgtggctgg tctccacgac
    12001 gcgcagctcg gtgaggttga ggttggggat gccggcctcg gcgatccgct tcagctcggc
    12061 ggcgtcaccg accgtcttcg gggccatcat cacgccgtcc gagccgtgct ccagcacgcc
    12121 gaagaggatc tccgcctcct ccaggtcctg cgcgatggtc accatcgaac cggaggcgcg
    12181 cgcggcggcg gcgatcacga tctccagcgg gatcttggtc gggtcgcgga acagcaggac
    12241 ggaccacttc tcggtccgcg aggactcgca ggcgtcctcc agcgtcggcg cgtcgatgat
    12301 ctccacgaac cgcccgaact cgatctccgg gtgcttgagc gccagttcgg cgggggtcac
    12361 accgtgcttc gacgggtcga cgacgacgac cgtcgcctcg ccgaactcct ccgggatctg
    12421 cttccccacc accagcagga ccttggccac ggtgggcggc aggtccgcga ggtgggcggg
    12481 gtcgtcggcg accagcgctt ccacccggtg gtgcagggcc tcctggacga tggcggcacg
    12541 ggcctcgccc acggaacgga tgtcgagcca ggtcagcttc gacgacgacg aaggcgacga
    12601 cgaagccgac gaggacgcag atgacgagga cgacgaggac ggagacggag acggagacga
    12661 agacatgaga gaactcctca gtggcgatgg gacggtgaac ggggactcgt ggtgcggttc
    12721 cgggcgctga cgtcggccgg atcaggcggc tccggcggcg gcgccggccg gagcccgggc
    12781 cgcgcccctg gtgccgctgt tgtggatgag gtcggagagc ttgtccgcca tcgcgccggg
    12841 atcaggggcc tggaagacgt tgcggcccat ggcgacaccg gccgcgccgc cgcgcagcgc
    12901 gtcgtcgacg taggcgagga tccggctctc gtcactgtcg cgcggtccgc cgaccacgac
    12961 gaccggaacg ggcgaggccg cggtgatctc ggccatcgcc gcgaccgatc cgacgtacag
    13021 cgtcttgacc aggtcggcgc cgaggtccac ggccacctgg acggcatggg cgacgagcgc
    13081 cggatcgcgc gggtcgtcga tcttggggcc gcgcggatac atcatcgcca gcagcggtac
    13141 gttccagcgg tcgcaggcct ccgcgaccgc cgccatgtcc gcgatctggt ggcgttcccc
    13201 ctcggagccg agattgacgt ggacgctcac cgcgtccgcg cccatgcgca ggctctcctc
    13261 gacgctcgac accaggtact tggcgttcgg gtcgggcgcg tgcacggtgc tggcgctgag
    13321 gtgcacgatc agcgaggtcc gcgtgaacca ctccgggtcc acgtggcgca gcgagccctt
    13381 gtgcaggacg atcccgtcga cgtggtggga ggccagttcg ccgacgagcg ggtcgaggcg
    13441 gtgggcacgg ctcagcgggc cgtcggtgat cgagtggtcg agcggcacga tgaacagccg
    13501 gtcggggtcg tggtgatgga gccgctggag tcgcagactc ctggcgaagg gcgcgttcgg
    13561 ggccatcagt gctcctgtcg ggtatcgccg gagagcatcg gcggagggtt ttccggccgg
    13621 gttcagggcc ggggagtcag gcttgcgggc accgcgcccg cctcggcgcc gaggccgaac
    13681 tcgctgtgca gcaggcccac cgcgcggacc gcgtcggagc ggggcaccgt caccgagacc
    13741 cgcagctggg acgcggtcag cgaccgggcg ctgatgccgg agccgacgag cgaggccagc
    13801 atccgggacg cgtactcggg ccggctgagc aggccctggc cgacgatcga gaccttggcg
    13861 acctggtcct cgacctcgac cccgtgcggg cgcggggcca tgaggtcgct gaacgaccgc
    13921 ccgacgtccg ccgcgtgcga gcggcgcacc gtgaaaccga gcgagaagcc gccgtcgggc
    13981 gcggaggaga ccgtggtcat gtcggcgggg atggactcct tcgccaggaa ccggaagacg
    14041 tcggcggagg ggtcgggggt gtcgtgggtg cgcagggtga tccgggcgat gtcggcgtcg
    14101 tggacgacgg ccgacaccgc cgtcctgtcc tcaagcatgt cgtttccgtc tcgtcgatgg
    14161 atacgggtgc cggtccgcgt ggccgtcgac cggcccacga ggatgtcgac gtcgtagagg
    14221 gcggccagtt cgacggcccg cgcgtgcatg acccgggctc cggcgaaggc catctcggtc
    14281 atcacgtcga tgtcgatgtc gggcatgagc cgggcgtcgg ggacgacgcg cgggtcagcg
    14341 gtgaacacgc cgggcacgtc gctgtagatc tcgcagtggc cggagcgcag ttcggccgcg
    14401 accgcgacgg ccgtggtgtc cgaaccgccg cggccgagcg tgatgatgtc gccctcggcg
    14461 gtgacgccct ggaaaccggc gagcaccacg gtccgcccgg cgtccaggag cgtgcgcaac
    14521 tggtcggtgt cgaccgcgac gatgaccccc gcgccgtgcg gcccggtggc gagcacgccg
    14581 ctgcgggcgc cggacagcgc ggtcgccgcc agtccgcccc gctggagggc catcgccatc
    14641 agcgccgcgg aggcggtctc gccggtggcg agcaactggt cgagttcgtg gcccgccggc
    14701 cgcgggttga ccgcctccgc ccggccgacc agctcgtcgg tggtgtcgcc ctgtgcggag
    14761 accacgacca ccacccgccg cccggagcgg gcgagcgcgc cgacccggtc ggcgacctga
    14821 cgtacctggg acacggtggc gagcgaactg ccgccgtact tctggaccac cacgtcgccc
    14881 gtgggacggc tgccctgcgt agtcac
//
