LOCUS       BGC0000663             13757 bp    DNA     linear   CON 06-FEB-2015
DEFINITION  Streptomyces coelicolor A3(2) complete genome.
ACCESSION   BGC0000663
VERSION     BGC0000663
KEYWORDS    .
SOURCE      Streptomyces coelicolor A3(2)
  ORGANISM  Streptomyces coelicolor A3(2)
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces; Streptomyces albidoflavus group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:11:05
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 7516016
            Orig. end    :: 7529773
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..912
                     /gene="SCO6759"
                     /gene_synonym="SC6A5.08"
     CDS             1..912
                     /codon_start=1
                     /db_xref="GOA:Q9X7V4"
                     /db_xref="InterPro:IPR002060"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR017827"
                     /db_xref="UniProtKB/TrEMBL:Q9X7V4"
                     /gene="SCO6759"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC6A5.08"
                     /note="SC6A5.08, probable phytoene synthase, len: 303aa;
                     similar to many eg. TR:Q50892 (EMBL:Z21955) phytoene
                     synthase from the light-induced carotenoid biosynthesis
                     cluster of Myxococcus xanthus (336 aa) fasta scores; opt:
                     322, z-score: 379.7, E(): 7.5e-14, (31.8% identity in 274
                     aa overlap). Contains Pfam match to entry PF00494 SQS_PSY,
                     Squalene and phytoene synthases, score 34.70, E-value
                     1.2e-08."
                     /product="putative phytoene synthase"
                     /protein_id="CAB39692.1"
                     /sec_met_domain="phytoene_synt (E-value: 3.6e-42, bitscore:
                     134.2, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVTDTAHAVDPERGTLAKAADENFPVAPFFLPRAWRTDLMAVYG
                     FARLVDDIGDGDLAPGGADARLLGVPEDRADDRLLMLDAFEADLRRVFDGSDGAPRHPL
                     LRRLVPTVRRRALTPEPFLGLIAANRQDQLVARYETYDDLLAYCELSANPVGRLVLAVT
                     GTSTPERIRRSDEICTALQIVEHLQDVAEDLGRDRIYLPAEDMKRFHVQEADLAAPSAN
                     ASVRALIAYEAARARDLLNEGAPLVGSVHGRLRLLLAGFVAGGRAALNAIAAADHDVLP
                     GPPKSGKVHLLREAGVVLRGEG"
     subregion       1..13757
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Terpene"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13757
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    94..717
                     /gene="SCO6759"
                     /gene_synonym="SC6A5.08"
                     /note="Pfam match to entry PF00494 SQS_PSY, Squalene and
                     phytoene synthases, score 34.70, E-value 1.2e-08."
     gene            921..1859
                     /gene="SCO6760"
                     /gene_synonym="SC6A5.09"
     CDS             921..1859
                     /codon_start=1
                     /db_xref="GOA:Q9X7V5"
                     /db_xref="InterPro:IPR002060"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR017828"
                     /db_xref="InterPro:IPR019845"
                     /db_xref="UniProtKB/TrEMBL:Q9X7V5"
                     /gene="SCO6760"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC6A5.09"
                     /note="SC6A5.09, probable phytoene synthase, len: 312aa;
                     similar to many egs. SW:CRTB_MYCTU probable phytoene
                     synthase from Mycobacterium tuberculosis (302 aa) fasta
                     scores; opt: 791, z-score: 925.6, E(): 0, (48.3% identity
                     in 286 aa overlap) and SW:PSY_ARATH phytoene synthase
                     precusor from Arabidopsis thaliana (mouse ear cress) (423
                     aa) fasta scores; opt: 493, z-score: 577.3, E(): 7.4e-25,
                     (34.4% identity in 282 aa overlap). Contains Pfam match to
                     entry PF00494 SQS_PSY, Squalene and phytoene synthases,
                     score 168.70, E-value 9.4e-47 and Prosite matches to
                     PS01044 Squalene and phytoene synthases signature 1 and
                     PS01045 Squalene and phytoene synthases signature 2."
                     /product="putative phytoene synthase"
                     /protein_id="CAB39693.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.6e-59, bitscore:
                     189.6, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESSANMPAPVLAAYSYCEAVTGQQARNFAHGIRLLPTPKRRAMS
                     ALYAFSRRVDDIGDGVLADDVKVTRLDETRAVLARIQDGAVEEDDTDPVAVALADAARR
                     FPIPLGGLDELIDGVQMDLRGETYETWDDLKVYCRCVAGAIGRLSLGVFGTEPGARGAE
                     RAPEYADTLGLALQLTNILRDVREDAEGGRTYLPADDLAKFGCAAGFNGPTPPEGSDFA
                     GLVHFEVRRARALFAEGYRLLPMLDRRSGACVAAMAGIYRRLLDRIERDPEAVLRGRVS
                     LPGREKAYVAVRGLSGLDARHVTRRTVRRRA"
     misc_feature    984..1820
                     /gene="SCO6760"
                     /gene_synonym="SC6A5.09"
                     /note="Pfam match to entry PF00494 SQS_PSY, Squalene and
                     phytoene synthases, score 168.70, E-value 9.4e-47."
     misc_feature    1329..1376
                     /gene="SCO6760"
                     /gene_synonym="SC6A5.09"
                     /note="PS01044 Squalene and phytoene synthases signature
                     1."
     misc_feature    1434..1511
                     /gene="SCO6760"
                     /gene_synonym="SC6A5.09"
                     /note="PS01045 Squalene and phytoene synthases signature
                     2."
     gene            1859..2017
                     /gene="SCO6761"
                     /gene_synonym="SC6A5.10"
     CDS             1859..2017
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q9X7V6"
                     /gene="SCO6761"
                     /gene_synonym="SC6A5.10"
                     /note="SC6A5.10, unknown, len: 52 aa; designated based upon
                     Hidden-Markov Model and probable ribosome binding site."
                     /product="small hypothetical protein"
                     /protein_id="CAB39694.1"
                     /transl_table=11
                     /translation="MDTPGTLDTRDPYKTGGGQWRATLRWRSASLTETVSRTPFKHRGG
                     RTGKGAP"
     gene            2014..3450
                     /gene="SCO6762"
                     /gene_synonym="SC6A5.11"
     CDS             2014..3450
                     /codon_start=1
                     /db_xref="GOA:Q9X7V7"
                     /db_xref="InterPro:IPR002937"
                     /db_xref="InterPro:IPR017830"
                     /db_xref="UniProtKB/TrEMBL:Q9X7V7"
                     /gene="SCO6762"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 58; E-value: 1.5e-17)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC6A5.11"
                     /note="SC6A5.11, possible phytoene dehydrogenase, len:
                     478aa; similar to many from eukaryotes eg. SW:CRTI_CAPAN
                     phytoene dehydrogenase precursor from Capsicum annuum (bell
                     pepper) (582 aa) fasta scores; opt: 276, z-score: 302.1,
                     E(): 1.6e-09, (24.0% identity in 459 aa overlap). Also
                     similar to prokaryotes eg. TR:P72449 (EMBL:X95596) proposed
                     dehydrogenase from a cryptic carotenoid biosynthesis
                     cluster in Streptomyces griseus (517 aa) fasta scores; opt:
                     206, z-score: 226.8, E(): 2.5e-05, (29.7% identity in 512
                     aa overlap)"
                     /product="putative phytoene dehydrogenase"
                     /protein_id="CAB39695.1"
                     /transl_table=11
                     /translation="MTQGKGTREGGVLADVSALGPGGHAVVVGGGLAGVTTALALADAG
                     VRVTLLEGRPRLGGLAFSFQRGDLTVDNGQHVYLRCCTAYRWFLDRIGGAALAPVQERL
                     DVPVVDLARTEGNRLGRLRRDALPVPLHLGRSLATYPHLSLAERASVGRAALALKGLDL
                     ADPSLDTQDFGSWLTAHGQSARAVEALWDLVGVATLNAVAGDASLGLAAMVFKTGLLSD
                     PGAADIGWARVPLGELHDRLARKALDSAGVRTEVRTRVTSVSVNENGGWSVQVPGETLE
                     ADAVVLAVPQREAHDLLPDGALDAPENLLRIGTAPILNIHVIYDRKVLGTPFLTALGTP
                     VQWVFDRTEASGLKEGQYLALSQSTAQNDIDEPVAVLRERYLPELERLLPRTRGAEVKD
                     FFVTRERTATFAPAPGVGRLRPGARTKAPGLYLAGAWTATGWPATMESAVRSGVGAAAA
                     ALGALGRSRGLLPDFFEEAA"
     gene            3447..4583
                     /gene="SCO6763"
                     /gene_synonym="SC6A5.12"
     CDS             3447..4583
                     /codon_start=1
                     /db_xref="GOA:Q9X7V8"
                     /db_xref="InterPro:IPR000092"
                     /db_xref="InterPro:IPR008949"
                     /db_xref="InterPro:IPR017446"
                     /db_xref="PDB:3NF2"
                     /db_xref="UniProtKB/TrEMBL:Q9X7V8"
                     /gene="SCO6763"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 274.6; E-value:
                     1.5e-83)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC6A5.12"
                     /note="SC6A5.12, probable polyprenyl synthatase, len:
                     378aa; similar to many eg. SW:GGPP_MYCTU probable
                     geranylgeranyl pyrophosphate synthatase from Mycobacterium
                     tuberculosis (359 aa) fasta scores; opt: 1103, z-score:
                     1231.0, E(): 0, (49.3% identity in 355 aa overlap) and
                     SW:IDSA_METTM short chain isoprenyl diphosphate synthase
                     from Methanobacterium thermoautotrophicum (324 aa) fasta
                     scores; opt: 547, z-score: 614.0, E(): 6.7e-27, (38.2%
                     identity in 293 aa overlap). Contains Pfam match to entry
                     PF00348 polyprenyl_synt, Polyprenyl synthetases, score
                     176.70, E-value 3.9e-49 and Prosite matches to PS00017
                     ATP/GTP-binding site motif A (P-loop), PS00723 Polyprenyl
                     synthetases signature 1 and PS00606 Beta-ketoacyl synthases
                     active site."
                     /product="putative polyprenyl synthatase"
                     /protein_id="CAB39696.1"
                     /transl_table=11
                     /translation="MKADPRGTGSRTPGTATGGKTVPTVPPAPTADRRTTVDVTALLER
                     GRTLATPVLRAAVDRLAPPMDTVAAYHFGWIDAQGNPADGDGGKAVRPALAVLSAEVTG
                     AAPEVGVPGAVAVELVHNFSLLHDDLMDGDEQRRHRDTVWKVHGPAQAILVGDALFALA
                     NEVLLELGTVEAGRATRRLTKASRSLIDGQAQDISYEHRDRVSVEECLEMEGNKTGALL
                     ACASSIGAVLGGADERTADTLEKYGYHLGLAFQAVDDLLGIWGDPDATGKQTWSDLRQR
                     KKSLPVVAALAAGGAASERLGEILTADAKASDFANFSEEEFAARAALIEEAGGREWTAD
                     EARRQHTIAIEALDAVDMPDRVRDRFTALADFVVVRKR"
     misc_feature    3486..3509
                     /gene="SCO6763"
                     /gene_synonym="SC6A5.12"
                     /note="PS00017 ATP/GTP-binding site motif A (P-loop)."
     misc_feature    3669..4436
                     /gene="SCO6763"
                     /gene_synonym="SC6A5.12"
                     /note="Pfam match to entry PF00348 polyprenyl_synt,
                     Polyprenyl synthetases, score 176.70, E-value 3.9e-49."
     misc_feature    3819..3863
                     /gene="SCO6763"
                     /gene_synonym="SC6A5.12"
                     /note="PS00723 Polyprenyl synthetases signature 1."
     misc_feature    4089..4139
                     /gene="SCO6763"
                     /gene_synonym="SC6A5.12"
                     /note="PS00606 Beta-ketoacyl synthases active site."
     gene            4700..6742
                     /gene="SCO6764"
                     /gene_synonym="SC6A5.13"
     CDS             4700..6742
                     /codon_start=1
                     /db_xref="GOA:Q9X7V9"
                     /db_xref="InterPro:IPR002365"
                     /db_xref="InterPro:IPR006400"
                     /db_xref="InterPro:IPR008930"
                     /db_xref="InterPro:IPR018333"
                     /db_xref="UniProtKB/TrEMBL:Q9X7V9"
                     /gene="SCO6764"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: terpene_cyclase"
                     /gene_kind="biosynthetic"
                     /gene_synonym="SC6A5.13"
                     /note="SC6A5.13, probable squalene-hopene cyclase, len: 680
                     aa; similar to many e.g. SW:SQHC_ALIAC squalene-hopene
                     cyclase A key enzyme in triterpenoid metabolism in Bacillus
                     acidocaldarius (630 aa) fasta scores; opt: 2153, z-score:
                     2386.3, E(): 0, (51.8% identity in 620 aa overlap).
                     Contains two Pfam matches to entry PF00432 prenyltrans,
                     Prenyltransferase and squalene oxidase repeats and a
                     Prosite match to PS01074 Terpene synthases signature."
                     /product="putative squalene-hopene cyclase"
                     /protein_id="CAB39697.1"
                     /sec_met_domain="terpene_cyclase (E-value: 8.6e-24,
                     bitscore: 74.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATTDGSTGASLRPLAASASDTDITIPAAAAGVPEAAARATRRA
                     TDFLLAKQDAEGWWKGDLETNVTMDAEDLLLRQFLGIQDEETTRAAALFIRGEQREDGT
                     WATFYGGPGELSTTIEAYVALRLAGDSPEAPHMARAAEWIRSRGGIASARVFTRIWLAL
                     FGWWKWDDLPELPPELIYFPTWVPLNIYDFGCWARQTIVPLTIVSAKRPVRPAPFPLDE
                     LHTDPARPNPPRPLAPVASWDGAFQRIDKALHAYRKVAPRRLRRAAMNSAARWIIERQE
                     NDGCWGGIQPPAVYSVIALYLLGYDLEHPVMRAGLESLDRFAVWREDGARMIEACQSPV
                     WDTCLATIALADAGVPEDHPQLVKASDWMLGEQIVRPGDWSVKRPGLPPGGWAFEFHND
                     NYPDIDDTAEVVLALRRVRHHDPERVEKAIGRGVRWNLGMQSKNGAWGAFDVDNTSAFP
                     NRLPFCDFGEVIDPPSADVTAHVVEMLAVEGLAHDPRTRRGIQWLLDAQETDGSWFGRW
                     GVNYVYGTGSVIPALTAAGLPTSHPAIRRAVRWLESVQNEDGGWGEDLRSYRYVREWSG
                     RGASTASQTGWALMALLAAGERDSKAVERGVAWLAATQREDGSWDEPYFTGTGFPWDFS
                     INYNLYRQVFPLTALGRYVHGEPFAKKPRAADAPAEAAPAEVKGS"
     misc_feature    6179..6307
                     /gene="SCO6764"
                     /gene_synonym="SC6A5.13"
                     /note="Pfam match to entry PF00432 prenyltrans,
                     Prenyltransferase and squalene oxidase repeats, score
                     29.90, E-value 5.7e-05."
     misc_feature    6227..6271
                     /gene="SCO6764"
                     /gene_synonym="SC6A5.13"
                     /note="PS01074 Terpene synthases signature."
     misc_feature    6323..6487
                     /gene="SCO6764"
                     /gene_synonym="SC6A5.13"
                     /note="Pfam match to entry PF00432 prenyltrans,
                     Prenyltransferase and squalene oxidase repeats, score
                     35.30, E-value 1.4e-06."
     gene            6742..7383
                     /gene="SCO6765"
                     /gene_synonym="SC6A5.14"
     CDS             6742..7383
                     /codon_start=1
                     /db_xref="GOA:Q9X7W0"
                     /db_xref="InterPro:IPR000845"
                     /db_xref="UniProtKB/TrEMBL:Q9X7W0"
                     /gene="SCO6765"
                     /gene_synonym="SC6A5.14"
                     /note="SC6A5.14, possible lipoprotein, len: 213 aa; similar
                     to SW:TYRT_STRLN proposed tyrosinase co-factor from the
                     melanin biosynthesis in Streptomyces lincolnensis (140 aa)
                     fasta scores; opt: 115, z-score: 142.8, E(): 1.2, (29.2%
                     identity in 120 aa overlap). Contains Prosite match to
                     PS00013 Prokaryotic membrane lipoprotein lipid attachment
                     site."
                     /product="putative lipoprotein"
                     /protein_id="CAB39698.1"
                     /transl_table=11
                     /translation="MTPQTGPSPLLIACALGIEHLALRTGDRAGAGGPVTVLRTGMGPR
                     AAERSVTRVLADPALEGAAVLATGFCAGLSPGMHPGDLVVAEETRDPRSTVPCVATDRL
                     VKELARAVPGRTVHTGPLTGSDHVVRGPERADLLATGAIAVDMESAATLLSAVRTGPRP
                     VAAVRVVVDAPEHELVRIGTVRGGISAFRVLRSVLPAFFEWHRSLLLPRR"
     misc_feature    6751..6783
                     /gene="SCO6765"
                     /gene_synonym="SC6A5.14"
                     /note="PS00013 Prokaryotic membrane lipoprotein lipid
                     attachment site."
     gene            7390..8412
                     /gene="SCO6766"
                     /gene_synonym="SC6A5.15"
     CDS             7390..8412
                     /codon_start=1
                     /db_xref="GOA:Q9X7W1"
                     /db_xref="InterPro:IPR006638"
                     /db_xref="InterPro:IPR007197"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR017833"
                     /db_xref="InterPro:IPR022563"
                     /db_xref="UniProtKB/TrEMBL:Q9X7W1"
                     /gene="SCO6766"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC6A5.15"
                     /note="SC6A5.15, unknown, len: 340 aa; similar to many of
                     undefined function e.g. TR:P95416 (EMBL:D84475) NirJ, from
                     a locus for heme D1 biosynthesis in Pseudomonas aeruginosa
                     (387 aa) fasta scores; opt: 222, z-score: 264.2, E():
                     2.1e-07, (24.2% identity in 207 aa overlap)."
                     /product="conserved hypothetical protein"
                     /protein_id="CAB39699.1"
                     /sec_met_domain="PF04055 (E-value: 9.4e-21, bitscore: 64.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAMPLRQSIKVATYLAEQKIRRRDKFPLIVELEPLFACNLACEGC
                     GKIQHPAGVLKQRMPVAQAVGAVLESGAPMVSIAGGEPLMHPQIDEIVRQLVAKRKYVF
                     LCTNAMLMRKKMDKFKPSPYFAFAVHIDGLRERHDESVAKEGVFDEAVEAIKEAKRRGF
                     RVTTNSTFFNTDTPQTIVEVLNFLNDDLKVDEMMISPAYAYEKAPDQEHFLGVEQTREL
                     FKKAFSGGNRARWRLNHSPLFLDFLEGKVDFPCTAWAIPNYSLFGWQRPCYLMSDGYVP
                     TYRELIEKTDWDKYGRGKDPRCDNCMAHCGYEPTAVLATMGSLKESLRAMRETVSGNRE
                     "
     gene            8417..9571
                     /gene="SCO6767"
                     /gene_synonym="SC6A5.16"
     CDS             8417..9571
                     /codon_start=1
                     /db_xref="GOA:Q9X7W2"
                     /db_xref="InterPro:IPR004588"
                     /db_xref="InterPro:IPR011005"
                     /db_xref="InterPro:IPR016425"
                     /db_xref="PDB:1OX2"
                     /gene="SCO6767"
                     /gene_synonym="SC6A5.16"
                     /note="SC6A5.16, GcpE protein homolog, len: 384 aa; similar
                     to many of undefined function e.g. TR:O33350
                     (EMBL:AL008883) hypothetical protein from Mycobacterium
                     tuberculosis (387 aa) fasta scores; opt: 1965, z-score:
                     2178.9, E(): 0, (78.2% identity in 385 aa overlap). Similar
                     to SW:P27433 (GCPE_ECOLI) essential protein from
                     Escherichia coli."
                     /product="GcpE protein homolog, conserved hypothetical
                     protein"
                     /protein_id="CAB39700.1"
                     /transl_table=11
                     /translation="MTAIPLGLPGVPVRPIAERRVSRRIQVGPVAVGGGAPVSVQSMTT
                     TRTSDIGATLQQIAELTASGCQIVRVACPTQDDADALPVIARKSQIPVIADIHFQPKYV
                     FAAIEAGCAAVRVNPGNIKQFDDKVKEIAKAAKDHGTPIRIGVNAGSLDRRLLQKYGRA
                     TPEALAESALWEASLFEEHDFRDIKISVKHNDPVVMVEAYRQLAAQCDYPLHLGVTEAG
                     PAFQGTIKSAVAFGALLSQGIGDTIRVSLSTPPVEEIKVGIQILESLNLRQRGLEIVSC
                     PSCGRAQVDVYKLAEEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI
                     FVKGEVVKTVPESKIVETLIEEAMRIAEQMEKDGASGAPAVTVS"
     gene            9597..11567
                     /gene="SCO6768"
                     /gene_synonym="SC6A5.17"
     CDS             9597..11567
                     /codon_start=1
                     /db_xref="GOA:Q9X7W3"
                     /db_xref="InterPro:IPR005474"
                     /db_xref="InterPro:IPR005475"
                     /db_xref="InterPro:IPR005476"
                     /db_xref="InterPro:IPR005477"
                     /db_xref="InterPro:IPR009014"
                     /db_xref="InterPro:IPR020826"
                     /db_xref="InterPro:IPR029061"
                     /gene="SCO6768"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     252.3; E-value: 8e-77)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC6A5.17"
                     /note="SC6A5.17, probable transketolase, len: 656 aa;
                     similar to many e.g. SW:DXS_MYCTU probable
                     1-deoxy-D-xylulose 5-phosphate from Mycobacterium
                     tuberculosis (638 aa) fasta scores; opt: 2501, z-score:
                     2761.8, E(): 0, (61.3% identity in 623 aa overlap) and
                     SW:DXS_ECOLI 1-deoxy-D-xylulose 5-phosphate from
                     Escherichia coli (619 aa) fasta scores; opt: 1480, z-score:
                     1634.7, E(): 0, (39.3% identity in 621 aa overlap). Also
                     similar to one from Streptomyces coelicolor which overlaps
                     2 cosmids - SC7B7.10 (TR:O50507 (EMBL:AL009199) fasta
                     scores; opt: 1790. z-score: 1601.6. E(): 0, (76.2% identity
                     in 353 aa overlap)) and SC1C3.01 (TR:O69843 (EMBL:AL023702)
                     fasta scores; opt: 1515, z-score: 1356.7, E(): 0, (69.1%
                     identity in 337 aa overlap). Contains Prosite match to
                     PS00801 Transketolase signature 1."
                     /product="probable transketolase"
                     /protein_id="CAB39701.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 7e-114, bitscore:
                     369.3, seeds: 174, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTILENIRGPRDLKALSEAELGELSDEIRDFLVHAVARTGGHLGP
                     NLGVVELTVALHRVFESPDDRILWDTGHQSYVHKLLTGRQDFSKLRSKGGLSGYPSREE
                     SAHDVIENSHASTVLGWADGLAKARQVQGERSHVVAVIGDGALTGGMAWEALNNIAAAR
                     DRPLIIVVNDNERSYAPTIGGLANHLATLRTTDGYERALAWGKDVLQRTPVVGHTVYEA
                     LHGAKKGFKDAFAPQGLFEDLGLKYLGPIDGHDIGAVESALRRAKRFHGPVLVHCLTEK
                     GRGYEPALRDEEDHFHTVGVMDPLTCEPLGPAGGPSWTSVFGEEIVRIGEERADVVAIT
                     AAMLHPVGLAPFAERFPDRVWDVGIAEQHAAVSAAGLATGGLHPVVAVYATFLNRAFDQ
                     LLMDVALHRCGVTFVLDRAGVTGVDGASHNGMWDMSVLQVVPGLRIAAPRDADQLRTQL
                     REAVAVDDAPTLLRFPKESVGPAVPAVDRIGGLDVLHTADRSEVLLVAVGVMAPVCLGA
                     AELLEARGIGCTVVDPRWVKPVDPALAPLAARHRLVAVVEDNSRAAGVGSAVALALGDA
                     EVDVPVRRFGIPEQFLAHAKRAEVLADIGLTPVDVAGRIAASLALAEPAGDRAGGPAVE
                     QPGDGRMSGDGRIVMPAQGEN"
     misc_feature    9681..9740
                     /gene="SCO6768"
                     /gene_synonym="SC6A5.17"
                     /note="PS00801 Transketolase signature 1."
     gene            11568..12953
                     /gene="SCO6769"
                     /gene_synonym="SC6A5.18"
     CDS             11568..12953
                     /NRPS_PKS="Domain: Aminotran_3 (41-363). E-value: 2.6e-91.
                     Score: 297.9. Matches aSDomain:
                     nrpspksdomains_SCO6769_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GOA:Q9X7W4"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:Q9X7W4"
                     /gene="SCO6769"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 373.2;
                     E-value: 2.7e-113)"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="SC6A5.18"
                     /note="SC6A5.18, probable aminotransferase, len: 461 aa;
                     similar to many e.g. SW:ARGD_BACSU acetylornithine
                     aminotransferase from Bacillus subtilis (385 aa) fasta
                     scores; opt: 663, z-score: 757.6, E(): 0, (37.8% identity
                     in 341 aa overlap). Contains Pfam match to entry PF00202
                     aminotran_3, Aminotransferases class-III
                     pyridoxal-phosphate and Prosite match to PS00600
                     Aminotransferases class-III pyridoxal-phosphate attachment
                     site."
                     /product="probable aminotransferase"
                     /protein_id="CAB39702.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.7e-92, bitscore:
                     298.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKEFDLAALLAERGAERYELHARHLNHQLPRMLHTIGFDKVYER
                     AEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVLDASLADLTRFDCPPLPGL
                     LAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRILYCPHAFHGLTAGSLSVN
                     GEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVEPVQGKGVHEAPPGYLLAA
                     QELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVCVAKALSGGYVPVGATLGK
                     DWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENEEIVANAAAVGERLKSRLA
                     ELVDRYELLADVRGRGLMIGIEFGRPRSLKLRSRWTMLQAARKGLFAQMVVVPLLQRHR
                     ILTQVSGDHLEVIKLIPPLIVDTDDADRFVDAFTEVMEDAHHGGGLMWDFGKTLVKQAV
                     ANR"
     aSDomain        11691..12656
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SCO6769_Aminotran_3.1"
                     /evalue="2.60E-91"
                     /label="SCO6769_Aminotran_3.1"
                     /locus_tag="SCO6769"
                     /protein_end="363"
                     /protein_start="41"
                     /score="297.9"
                     /tool="antismash"
                     /translation="VYERAEGAHFWDADGNDYLDMLAGFAVMGLGRHHPVVRKALHDVL
                     DASLADLTRFDCPPLPGLLAEKLLSYSPHLDRVFFGNSGTEAVETALKFARYATGRQRI
                     LYCPHAFHGLTAGSLSVNGEDGFRKGFAPLLPDTAVPLGDLDALARELKKGDVAALIVE
                     PVQGKGVHEAPPGYLLAAQELLHRHKALLIADEVQTGLGRTGKFYAYQHSDGVEPDLVC
                     VAKALSGGYVPVGATLGKDWIFQKVYSSMDRVQVHSASFGSNAQAMAAGLAVLSVMENE
                     EIVANAAAVGERLKSRLAELVDRYELLADVRGRGLMIGIEF"
     misc_feature    11709..12749
                     /gene="SCO6769"
                     /gene_synonym="SC6A5.18"
                     /note="Pfam match to entry PF00202 aminotran_3,
                     Aminotransferases class-III pyridoxal-phosphate, score
                     343.70, E-value 5.1e-119."
     misc_feature    12264..12380
                     /gene="SCO6769"
                     /gene_synonym="SC6A5.18"
                     /note="PS00600 Aminotransferases class-III
                     pyridoxal-phosphate attachment site."
     gene            13027..13641
                     /gene="SCO6770"
                     /gene_synonym="SC6A5.19"
     CDS             13027..13641
                     /codon_start=1
                     /db_xref="GOA:Q9X7W5"
                     /db_xref="InterPro:IPR001387"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR013096"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:Q9X7W5"
                     /gene="SCO6770"
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 113.9; E-value: 1.7e-34)"
                     /gene_kind="other"
                     /gene_synonym="SC6A5.19"
                     /note="SC6A5.19, probable DNA-binding protein, len: 204 aa;
                     similar to several of undefined function eg. TR:O86784
                     (EMBL:AL031317) hypothetical protein from Streptomyces
                     coelicolor (201 aa) fasta scores; opt: 297, z-score: 356.2,
                     E(): 1.5e-12, (34.9% identity in 212 aa overlap). Contains
                     Pfam match to entry PF01381 HTH_3, Helix-turn-helix."
                     /product="putative DNA-binding protein"
                     /protein_id="CAB39703.1"
                     /transl_table=11
                     /translation="MSSSETGPAEGAVAAVAPQLRELRRRAALTLEAAARAAGLSPAHL
                     SRLETGQRQPSLPMLLSLARVYGTTVAELLGESAADRDAVVRAADMEPTAAGGWTYWRA
                     GAPGRGMQALRVQVPYGSQGDVVRVHPGEEWLHVLRGRLRLRLGDTEHRLTAGDSAHFD
                     SMTPHRIAAQDPDGVELLFVHTLLQSPTAALCLGPTPGETP"
     misc_feature    13084..13248
                     /gene="SCO6770"
                     /gene_synonym="SC6A5.19"
                     /note="Pfam match to entry PF01381 HTH_3, Helix-turn-helix,
                     score 52.80, E-value 7.6e-12."
     gene            13638..13757
                     /gene="SCO6771"
                     /gene_synonym="SC6A5.20"
     CDS             13638..13757
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q9X7W6"
                     /gene="SCO6771"
                     /gene_synonym="SC6A5.20"
                     /note="SC6A5.20, possible small hydrophobic secreted
                     protein, len: 39 aa; contains possible N-terminal signal
                     sequence."
                     /product="putative small hydrophobic secreted protein"
                     /protein_id="CAB39704.1"
                     /transl_table=11
                     /translation="MSTMQEKFPRALWVRLIVYIALGHVFGGFLYLLFEVGAK"
ORIGIN
        1 atgacggtca ccgacacggc gcacgccgtc gacccggagc gcggcaccct cgccaaggcc
       61 gccgacgaga acttccccgt cgcccccttc ttcctgcccc gcgcctggcg caccgacctc
      121 atggccgtct acggcttcgc ccgtctcgtc gacgacatcg gcgacggcga cctcgccccg
      181 ggcggagcgg acgcccgcct gctcggcgtc cccgaggacc gcgccgacga ccgactgctg
      241 atgctggacg ccttcgaggc ggacctgcgt cgtgtcttcg acggctccga cggtgcgccc
      301 cgccacccgc tgctgcgccg tctggtgccc accgtgcgcc gccgcgcgct gacccccgag
      361 cccttcctcg gcctgatcgc cgccaaccgg caggaccagc tggtcgcacg gtacgagacc
      421 tacgacgacc tcctcgccta ctgcgagctg tccgccaacc ccgtcggccg tctcgtcctc
      481 gccgtcaccg gcacctcgac ccccgaacgg atccgccgct ccgacgagat ctgcaccgcc
      541 ctgcagatcg tcgagcacct ccaggacgtc gccgaggacc tcggacggga ccggatctac
      601 ctgcccgccg aggacatgaa gcgcttccac gtccaggagg cggacctcgc cgcgcccagc
      661 gcgaacgcct ccgtgcgcgc gctgatcgcc tacgaggccg cccgcgcccg cgacctgctg
      721 aatgaaggcg cccccctggt gggtagcgtc cacggcaggc tgcgactgct cctggcgggc
      781 ttcgtggcgg gtggcagggc ggcgctgaac gcgatcgccg cggcggatca cgacgtactt
      841 cccggcccgc ccaagtcagg caaggtccac ttgctgcgcg aggcgggcgt ggtcctgcga
      901 ggagaggggt gatcgggtcc gtggagtcgt cagcgaacat gccggcaccg gtgctcgccg
      961 cctacagcta ctgcgaggcc gtcaccggtc agcaggcacg caacttcgcc cacggcatcc
     1021 ggctgctgcc cacgcccaag cggcgggcga tgtccgcgct gtacgcgttc tcgcgccggg
     1081 tcgacgacat cggcgacgga gtgctggcgg acgacgtcaa ggtcacccgg ctggacgaga
     1141 cccgggccgt gctcgcccgg atccaggacg gcgcggtcga ggaggacgac accgacccgg
     1201 tcgccgtcgc cctcgccgac gcggcccggc ggtttcccat cccgctcggc ggcctcgacg
     1261 agctgatcga cggcgtccag atggacctgc gcggcgagac ctacgagacc tgggacgacc
     1321 tgaaggtcta ctgccgctgc gtggcgggcg ccatcggacg cctctcgctc ggcgtcttcg
     1381 gcaccgaacc gggggcgcgc ggcgccgagc gcgcgcccga gtacgccgac acgctcgggc
     1441 tcgcgctgca gctcaccaac atcctgcgcg acgtccggga ggacgccgag ggcgggcgca
     1501 cctacctgcc cgccgacgac ctcgccaagt tcggctgcgc ggccggattc aacggcccga
     1561 caccacccga gggctccgac ttcgcgggcc tcgtgcactt cgaagtgcgt cgggcccgcg
     1621 cccttttcgc cgagggctac cggctgctgc ccatgctcga ccggcgcagc ggcgcctgcg
     1681 tggccgccat ggccggcatc taccgccgtc tcctggaccg catcgagcgc gaccccgagg
     1741 ccgtactgcg cggccgggtc tccctgccgg gacgcgagaa ggcgtacgtc gccgtgcgcg
     1801 gcctgtccgg cctcgacgcc cggcacgtca cccggcggac cgtcaggagg cgcgcctgat
     1861 ggacacaccg ggcacactcg acacccggga cccgtacaaa accggcggcg ggcagtggcg
     1921 ggcaaccctg cggtggcggt cggcgtccct gactgagacg gtcagccgta cgccgttcaa
     1981 acaccgcggc ggccggacag ggaagggcgc accatgacgc agggcaaggg cacgcgcgag
     2041 ggcggagtgc tcgcggacgt ctcggccctc ggccccggcg ggcatgccgt cgtggtcggc
     2101 ggcggactcg cgggggtcac caccgcgctg gcactggcgg acgccggtgt gcgcgtcacc
     2161 ctgctcgaag gacgcccccg gctcggcggg ctcgccttct ccttccagcg cggcgacctc
     2221 accgtcgaca acggccagca cgtgtacctg cgctgctgca ccgcctaccg gtggttcctc
     2281 gaccggatcg gcggagccgc gctcgcaccg gtgcaggaac gtctcgacgt gcccgtggtc
     2341 gacctggcga ggaccgaggg caaccggctc ggcagactgc ggcgcgacgc gctgcccgtc
     2401 cccctgcatc tggggcgcag cctcgcgacc tacccgcacc tctccctcgc cgaacgcgcc
     2461 tcggtgggac gcgccgcgct cgcgctcaag gggctcgacc tcgccgatcc gagcctggac
     2521 acccaggact tcggcagctg gctgaccgcg cacggtcagt cggcgcgtgc cgtcgaggcc
     2581 ctgtgggacc tggtcggggt cgccaccctc aacgcggtcg cgggcgacgc ctcgctgggg
     2641 ctcgccgcga tggtgttcaa gaccggtctg ctgtccgacc cgggagcggc cgacatcggg
     2701 tgggcccgtg tcccgctggg cgaactgcac gaccggctgg cccgcaaggc gctcgactcc
     2761 gcgggcgtcc gtaccgaggt ccgtacacgc gtcacctccg tctccgtaaa cgagaacggc
     2821 ggctggagcg ttcaggttcc cggcgagacg ctcgaagcgg acgccgtcgt cctcgccgta
     2881 ccccagcgcg aggcccacga cctgctgccg gacggtgcgc tggacgcccc ggaaaatctt
     2941 ctgcggatcg gcaccgcgcc gatcctcaac atccacgtga tctacgaccg caaggtgctc
     3001 ggcacgccgt tcctcacggc cctcggcacc ccggtccagt gggtgttcga ccgcaccgag
     3061 gcctccgggc tgaaggaggg tcagtacctg gcgctgtccc agtcgaccgc gcagaacgac
     3121 atcgacgagc ccgtggccgt gctgcgcgag cggtacctgc ccgaactgga gcggctgctg
     3181 ccgcgcaccc ggggtgccga ggtgaaggac ttcttcgtga ccagggagcg caccgccacg
     3241 ttcgcccccg cccccggcgt cgggcgcctc aggcccggcg cccgcaccaa ggcacccggc
     3301 ctctacctgg ccggagcgtg gaccgccacc gggtggcccg cgaccatgga gagtgcggtt
     3361 cgcagcggtg tcggggcggc ggccgccgcg ctcggcgccc tgggccggtc ccgcggcctc
     3421 cttcccgatt tcttcgagga ggcggcgtga aagccgatcc gcgcgggacc ggctcccgca
     3481 ctcccggcac cgcaactgga ggaaagactg tgcccactgt gcccccggcc ccgacggccg
     3541 atcgacggac cacggtggac gtgaccgcgc ttctggagcg cggccggacc ctggccacgc
     3601 cggtcctgcg ggcggccgtc gaccgcctgg cccctcccat ggacaccgtc gccgcctacc
     3661 acttcggctg gatcgacgcc cagggcaacc ccgcggacgg cgacggtggc aaggccgtcc
     3721 gccccgcgct cgccgtgctc tccgccgagg tcaccggcgc cgcccccgag gtcggcgtgc
     3781 ccggcgcggt ggccgtggaa ctggtgcaca acttctccct cctgcacgac gacctgatgg
     3841 acggcgacga gcagcgccgc caccgcgaca ccgtctggaa ggtgcacggc cccgcccagg
     3901 ccatcctggt cggcgacgcc ctgttcgccc tcgccaacga ggtgctgctc gaactgggca
     3961 ccgtcgaggc cgggcgggcc acccgccgcc tgaccaaggc cagccgctcc ctgatcgacg
     4021 gtcaggccca ggacatctcc tacgagcacc gcgaccgcgt cagcgtcgag gagtgcctgg
     4081 agatggaggg caacaagacc ggcgccctgc tcgcctgcgc cagctccatc ggcgcggtgc
     4141 tcggcggcgc cgacgaacgc accgccgaca ccctggagaa gtacggctac cacctcggtc
     4201 tcgccttcca ggccgtcgac gacctgctcg gcatctgggg cgacccggac gccaccggca
     4261 agcagacctg gagcgacctg cgccagcgca agaagtcgct gccggtcgtc gccgccctcg
     4321 cggccggcgg ggccgcttcc gagcggctcg gcgagatcct cacggccgac gccaaggcca
     4381 gcgacttcgc gaacttctcc gaggaggagt tcgcggcccg cgccgccctc atcgaggaag
     4441 cgggcgggcg ggagtggacc gccgacgagg cgcgtcgcca gcacaccatc gccatcgaag
     4501 ccctcgacgc cgtcgacatg cccgaccggg tgcgggaccg gttcacggcc ctcgcggact
     4561 tcgtcgtcgt acgaaagaga tgatcattat cggtcgaata gccctcgcgt agtcgccggc
     4621 cggtgtcgtg gagacacgag caccggccga cggcggaccc agcagacgca ccacatgcac
     4681 actgcacgaa ggggaagcca tgacagcgac gaccgacgga agcaccggag cctccctgcg
     4741 gcccctggca gcctcggcca gcgacaccga catcacgatc cccgccgcgg cggccggggt
     4801 acccgaagcc gccgcccgcg ccacccggcg tgccaccgac ttcctgctcg ccaagcagga
     4861 cgccgagggc tggtggaagg gcgacctcga gacgaacgtc acgatggacg ccgaggacct
     4921 gctcctgcgt cagttcctgg gcatccagga cgaggagacc acccgcgccg ccgcgctgtt
     4981 catccgcggc gagcagcgcg aggacggcac ctgggccacc ttctacggcg gccccggcga
     5041 actgtccacg accatcgagg cctacgtcgc cctccgcctg gccggcgact cacccgaggc
     5101 gccccacatg gcgcgggccg cggagtggat caggtcccgc ggcggcatcg cctccgcccg
     5161 ggtcttcacc cggatctggc tggccctgtt cggctggtgg aagtgggacg acctgcccga
     5221 actcccgccg gagctgatct acttccccac ctgggtcccg ctcaacatct acgacttcgg
     5281 ctgctgggcc cggcagacca tcgtgccgct caccatcgtc tccgcgaagc ggccggtgcg
     5341 tcccgcgccg ttcccgctgg acgaactgca caccgacccg gcccgcccca acccgccacg
     5401 ccccctggca cccgtggcca gctgggacgg cgccttccag cgcatcgaca aggccctgca
     5461 cgcctaccgc aaggtcgccc cgcgccggct gcgccgggcc gcgatgaaca gcgccgcccg
     5521 ctggatcatc gagcggcagg agaacgacgg ctgctggggc ggcatccagc cgcctgcggt
     5581 ctactcggtc atcgccctct acctgctcgg ctacgacctc gaacaccccg tgatgcgcgc
     5641 gggactggag tcgctggacc gtttcgccgt ctggcgcgag gacggcgccc ggatgatcga
     5701 ggcctgccag tccccggtgt gggacacctg cctggccacc atcgcgctgg ccgacgcggg
     5761 cgtgcccgag gaccacccgc agctggtgaa ggcctcggac tggatgctcg gcgaacagat
     5821 cgtgcgcccc ggcgactggt cggtgaagcg ccccggactc ccgcccggcg gctgggcgtt
     5881 cgagttccac aacgacaact accccgacat cgacgacacc gccgaggtgg tcctcgccct
     5941 gcgccgggtc aggcaccacg acccggaacg ggtggagaag gcgatcgggc gcggggtgcg
     6001 ctggaacctc ggcatgcagt cgaagaacgg cgcctggggc gccttcgacg tcgacaacac
     6061 cagcgccttc cccaaccggc tgccgttctg cgacttcggc gaggtcatcg acccgccgtc
     6121 cgcggacgtc accgcgcacg tcgtcgagat gctcgccgtc gagggcctcg cccacgaccc
     6181 gcgcacccgc cgcggcatcc agtggctgct cgacgcccag gagacggacg gttcgtggtt
     6241 cggccgctgg ggcgtcaact acgtctacgg caccggttcc gtgatccccg cgctgaccgc
     6301 ggccggactg cccacctcgc acccggccat ccgccgggcg gtgcgctggc tggagtccgt
     6361 ccagaacgag gacggcggct ggggcgagga cctgcgctcc taccgctacg tccgggagtg
     6421 gagcggccgg ggcgcctcga ccgcctcgca gaccggctgg gcgctgatgg ccctgctggc
     6481 ggcaggggag cgggactcca aagccgtgga gcgcggcgtc gcatggctcg cggccaccca
     6541 gcgggaggac ggctcctggg acgagcccta cttcacgggc accggcttcc cgtgggactt
     6601 ctccatcaac tacaacctct accgccaggt cttcccgctc accgctctcg gccggtacgt
     6661 ccacggggag cccttcgcca agaagccccg cgcggccgac gcccccgccg aagccgcccc
     6721 ggccgaggtg aagggcagct gatgaccccg cagaccggcc cgtccccgct gctgatcgcc
     6781 tgcgcgctcg gcatcgagca cctcgccctg cgcaccggcg accgcgccgg cgccggcggg
     6841 ccggtcaccg tcctgcgcac cggcatgggt cccagggcgg ccgaacgctc ggtcacccgg
     6901 gtcctcgccg acccggcgct cgagggcgcc gccgtgctcg ccacgggctt ctgcgccgga
     6961 ctctcgcccg gcatgcaccc cggtgacctg gtcgtcgccg aggagacccg ggacccgcgc
     7021 tccaccgtcc cctgcgtcgc gaccgaccgg ctcgtcaagg aactcgcgcg agccgtcccc
     7081 gggcgcaccg tccacaccgg gccgctgacc ggctcggacc acgtcgtccg cggccccgaa
     7141 cgcgccgacc tgctcgcgac cggcgcgatc gccgtggaca tggagtccgc ggccacgctc
     7201 ctgagcgccg tccgcacggg tccgcgcccg gttgcggccg tccgagtggt cgtggacgct
     7261 ccagaacacg aactcgtccg gatcggcacc gtgcgcggtg gaatatcggc cttccgtgtt
     7321 cttcgatccg ttcttcccgc atttttcgaa tggcaccgtt ctttgttgct tccccggagg
     7381 tgagcccaga tggccatgcc gctgcgccag tccatcaagg tcgctacata cctggccgaa
     7441 cagaagattc gccgacggga caagttcccg ctcatcgtgg agctggaacc gctcttcgcc
     7501 tgcaacctgg cgtgcgaggg atgcggcaag atccagcacc ccgccggtgt gctcaagcag
     7561 cgcatgccgg tcgcacaggc cgtcggggcg gtgctggaat cgggcgcgcc gatggtctcc
     7621 atcgccggcg gcgagcccct gatgcacccg cagatcgacg agatcgtgcg gcagttggtg
     7681 gccaagcgga agtacgtctt cctctgcacc aacgccatgc tcatgcgcaa gaagatggac
     7741 aagttcaagc cctcgccgta cttcgccttc gcggtgcaca tcgacggact gcgcgagcgg
     7801 cacgacgagt ccgtggcgaa ggagggcgtg ttcgacgagg ccgtggaggc catcaaggag
     7861 gccaagcggc gcggcttccg ggtgaccacc aactcgacct tcttcaacac cgacaccccg
     7921 cagaccatcg tcgaggtgct caacttcctc aacgacgacc tcaaggtcga cgagatgatg
     7981 atctcgcccg cctacgccta cgagaaggca cccgaccagg agcacttcct gggcgtggag
     8041 cagacccgcg agctgttcaa gaaggccttc tcgggcggca accgggcccg ctggcggctc
     8101 aaccactccc cgctgttcct cgacttcctc gagggcaagg tcgacttccc gtgcaccgcg
     8161 tgggcgatcc cgaactactc cctcttcggc tggcagcgcc cctgctacct gatgagcgac
     8221 ggctacgtcc cgacgtaccg ggagctgatc gagaagaccg actgggacaa gtacggccgc
     8281 ggcaaggacc cgcgctgcga caactgcatg gcgcactgcg gctacgagcc caccgccgtc
     8341 ctggccacca tgggctcgct caaggagtcc ctgcgcgcca tgcgggagac ggtctccggg
     8401 aaccgggagt gacgtcgtga ccgccatccc cttggggctc cccggggtac cggtccggcc
     8461 gatcgccgag cggcgcgtgt cgcggcggat ccaggtcggg ccggtggcgg tcgggggcgg
     8521 ggctccggtg tcggtgcagt cgatgacgac cacccgtacg tccgacatcg gggccacgct
     8581 ccagcagatc gccgagctga cggcgtcggg ctgccagatc gtccgggtgg cctgtcccac
     8641 ccaggacgac gccgacgcgc tgcccgtcat cgcgaggaag tcgcagatcc cggtgatcgc
     8701 ggacatccac ttccagccca agtacgtctt cgccgcgatc gaggccggct gcgcggcggt
     8761 ccgggtgaac ccgggcaaca tcaagcagtt cgacgacaag gtcaaggaga tcgccaaggc
     8821 ggcgaaggac cacggcacgc ccatccgcat cggtgtgaac gccggctccc tcgaccgccg
     8881 cctgctccag aagtacggca gggcgacccc cgaggccctc gccgagtccg ccctctggga
     8941 ggcgtcgctc ttcgaggagc acgacttccg cgacatcaag atctcggtca agcacaacga
     9001 cccggtcgtc atggtcgagg cctaccggca actcgccgcc cagtgcgact acccgctgca
     9061 cctgggggtg acggaggccg ggcccgcgtt ccagggcacc atcaagtccg ccgtcgcctt
     9121 cggcgcgctg ctctcgcagg gcatcggcga caccatccgg gtgtcgctca gcaccccgcc
     9181 ggtcgaggag atcaaggtcg gcatccagat cctggagtcg ctgaacctgc gccagcgcgg
     9241 cctggagatc gtctcctgcc cgtcctgcgg ccgcgcccag gtcgacgtct acaagctggc
     9301 cgaggaggtc accgccgggc tggagggcat ggaggtgccg ctgcgcgtgg ccgtcatggg
     9361 ctgcgtcgtc aacggccccg gtgaggcccg cgaggcggac ctcggcgtcg cctccggcaa
     9421 cggcaagggg cagatcttcg tcaagggcga ggtcgtcaag accgtgcccg agtcgaagat
     9481 cgtggagacc ctcatcgagg aggcgatgag gatcgcggag cagatggaga aggacggcgc
     9541 ctcgggggcg ccggccgtca ccgtgagctg aaacgcggac cgaagggggc ccgagcgtga
     9601 cgattctgga gaacatccgg ggaccacgcg acctgaaggc gctgtccgag gcggaactcg
     9661 gtgaactgtc cgacgagata cgtgacttcc tggtgcacgc ggtcgcccgc accggcggtc
     9721 acctcggacc caacctcggc gtggtggaac tcaccgtcgc cctgcaccgg gtcttcgagt
     9781 cgccggacga ccgcatcctg tgggacaccg gccatcagag ctatgtgcac aaactcctga
     9841 ccggacgtca ggacttctcc aagctgcgga gcaagggcgg cctttccggc tacccctcgc
     9901 gcgaggagtc cgcgcacgac gtcatcgaga acagccacgc ctccaccgtc ctcggctggg
     9961 ccgacggcct cgccaaggcc cgccaggtgc agggggagcg cagccacgtc gtcgccgtca
    10021 tcggtgacgg cgcgctcacc ggcggcatgg cctgggaggc gctgaacaac atcgcggcgg
    10081 ccagggaccg gccgctgatc atcgtcgtca acgacaacga acgctcgtac gcgccgacca
    10141 tcggcggcct cgccaaccac ctggcgaccc tgcgcaccac cgacggctac gagcgggccc
    10201 tggcctgggg caaggacgtg ctccagcgca cgcccgtggt gggccacacc gtctacgagg
    10261 ccctgcacgg cgccaagaag ggcttcaagg acgccttcgc cccgcagggg ctcttcgagg
    10321 acctgggact gaagtacctc ggtccgatcg acgggcacga catcggcgcc gtcgagtcgg
    10381 cgctccgccg cgcgaagcgc ttccacggcc cggtgctcgt gcactgcctc accgagaagg
    10441 gccgcggcta cgagcccgcc ctgcgcgacg aggaggacca cttccacacg gtcggcgtga
    10501 tggacccgct cacctgcgag ccgctcggcc cggcgggcgg gccgtcctgg acctccgtgt
    10561 tcggtgagga gatcgtccgg atcggcgagg agcgcgcgga cgtggtggcg atcaccgcgg
    10621 ccatgctgca cccggtcggt ctcgcccctt tcgccgaacg gttccccgac cgcgtctggg
    10681 acgtcggcat cgccgagcag cacgccgccg tctccgccgc cggcctcgcc accggcggac
    10741 tgcacccggt cgtcgccgtc tacgccacct tcctcaaccg cgccttcgac cagctcctga
    10801 tggacgtggc cctgcaccgc tgcggcgtca ccttcgtcct ggaccgggcc ggcgtcaccg
    10861 gcgtcgacgg cgcctcgcac aacggcatgt gggacatgtc cgtcctccag gtcgtccccg
    10921 gactgcggat cgccgccccg cgcgacgccg accagctgcg cacccagctg cgcgaggcgg
    10981 tcgccgtgga cgacgcgccg acgctgctgc gcttcccgaa ggagtccgtc ggccccgccg
    11041 tgcccgccgt cgaccggatc ggcggcctgg acgtcctgca caccgccgac cggtccgagg
    11101 tgctgctcgt ggcggtgggc gtgatggcac ccgtctgcct cggggccgcc gaactcctcg
    11161 aggcccgcgg catcggctgc accgtcgtcg acccgcgctg ggtcaagccg gtcgacccgg
    11221 cgctcgcacc gctcgcggcc cggcaccggc tggtcgccgt ggtcgaggac aacagccggg
    11281 ccgccggggt cggttccgcg gtggcgctgg cgctcggcga cgccgaggtc gacgtccccg
    11341 tgcgccgctt cggcatcccc gagcagttcc tcgcgcacgc caagcgcgcc gaggtgctcg
    11401 cggacatcgg cctcaccccg gtcgacgtcg ccgggcggat cgccgcgagt ctggccctcg
    11461 ccgagccggc cggggaccgg gcgggtggac cggcagtgga acagcccggc gacggacgga
    11521 tgtccggcga cggacggatc gtcatgccag cgcaaggaga gaactgaatg accaaggagt
    11581 tcgacctcgc cgcgctcttg gccgagcgcg gggccgagcg gtacgagctg cacgccaggc
    11641 acctcaacca ccagctgccg cgcatgctgc acaccatcgg cttcgacaag gtctacgagc
    11701 gggccgaggg cgcgcacttc tgggacgcgg acggcaacga ctacctggac atgctcgccg
    11761 ggttcgcggt gatgggcctg ggccgccacc acccggtcgt ccgcaaggcg ctgcacgacg
    11821 tgctcgacgc ctcgctcgcc gacctgaccc gcttcgactg cccgccgctg ccgggcctgc
    11881 tggccgagaa gctgctctcc tacagcccgc acctggaccg cgtcttcttc ggcaacagcg
    11941 gcaccgaggc cgtcgagacc gcgctgaagt tcgcccggta cgcgaccggc agacagcgga
    12001 tcctgtactg cccgcacgcc ttccacggac tgacggccgg ctccctctcc gtcaacggag
    12061 aggacggctt ccgcaaaggc ttcgcaccgc tgctgcccga caccgccgtc ccgctcggcg
    12121 acctcgacgc cctggcgcgg gagctgaaga agggcgacgt ggccgccctg atcgtggagc
    12181 cggtccaggg caagggcgtg cacgaggccc cgcccggcta cctgctcgcc gcgcaggagc
    12241 tgctgcaccg gcacaaggcg ctgctgatcg ccgacgaggt gcagacgggc ctcggccgga
    12301 ccggcaagtt ctacgcctac cagcactcgg acggggtgga gcccgacctg gtctgcgtgg
    12361 ccaaggcgct gtccggcgga tacgtcccgg tgggtgccac cctgggcaag gactggatct
    12421 tccagaaggt gtactcctcg atggaccgcg tgcaggtcca ctcggcgagc ttcgggtcca
    12481 acgcacaggc catggccgcc gggctcgcgg tgctgtcggt gatggagaac gaggagatcg
    12541 tcgcgaacgc cgccgcggtg ggggagcggc tgaagtcccg gcttgcggag ctggtggacc
    12601 gctacgagct gctcgccgac gtccggggcc gcggactgat gatcggcatc gagttcggcc
    12661 ggcccaggtc cctgaagctg cgcagccgct ggacgatgct gcaggcggcg cggaagggac
    12721 tgttcgcgca gatggtggtc gtgccgctgc tgcaacggca ccggatcctg acccaggtgt
    12781 ccggcgacca cctggaggtg atcaagctga tcccgccgct gatcgtcgac accgacgacg
    12841 ccgaccggtt cgtcgacgcc ttcacggagg tgatggagga cgcgcaccat ggcggtggcc
    12901 tgatgtggga cttcgggaag accctggtca agcaggcggt ggccaaccgc tgagcgcacc
    12961 ctccaggtct tttgcctctg aggcaaggaa tttgcctggc gggcaagatt cgggctgaat
    13021 ggaggcatga gctcctccga gaccggcccc gccgaggggg cggtcgccgc cgtcgcgccc
    13081 cagctgcgtg agctgcggcg gcgggccgcc ctcaccctgg aggccgccgc ccgcgccgca
    13141 gggctctcgc ccgcccacct ctcccgcctg gagaccgggc agcgccagcc ctcgctgccg
    13201 atgctgctct ccctcgcccg ggtctacggt acgaccgtcg ccgagctgct gggcgagtcg
    13261 gccgcggacc gggacgccgt cgtgcgcgcc gccgacatgg aacccaccgc cgcgggcggc
    13321 tggacgtact ggcgggccgg agcgccgggc cgcggcatgc aggccctgcg cgtccaggtt
    13381 ccgtacggct cccagggcga cgtcgtgcgg gtgcaccccg gcgaggagtg gctgcacgtc
    13441 ctgcggggcc ggctgcgact gcgcctcggg gacaccgagc accggctcac cgcgggggac
    13501 agcgcccact tcgactcgat gaccccgcac cggatcgccg cgcaggaccc cgacggggtc
    13561 gagctgctgt tcgtccacac cctgctgcag agcccgacgg ccgccctgtg cctcggcccg
    13621 acccctggag agacgccatg agcaccatgc aggagaagtt cccgcgcgcc ctgtgggtgc
    13681 ggctgatcgt ctacatcgcc ctggggcacg tcttcggcgg cttcctctac ctgctgttcg
    13741 aggtgggcgc caagtag
//
