LOCUS       BGC0000665             21259 bp    DNA     linear   BCT 16-OCT-2012
DEFINITION  Streptomyces sp. HKI0576 gene cluster for the biosynthesis of
            indolosesquiterpenoids, strain HKI0576.
ACCESSION   BGC0000665
VERSION     BGC0000665
KEYWORDS    .
SOURCE      Streptomyces sp. HKI0576
  ORGANISM  Streptomyces sp. HKI0576
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:00:41
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..1002
                     /gene="xiaA"
     CDS             1..1002
                     /codon_start=1
                     /function="4-hydroxy-3-methylbut-2-enyl diphosphate
                     reductase"
                     /gene="xiaA"
                     /product="XiaA protein"
                     /protein_id="CCH63727.1"
                     /transl_table=11
                     /translation="MTDVSSDTYAGSGVRRRVLLAGPRSFCAGVERAIEIVERALESRG
                     APVYVRKQIVHNVTVVDDLADRGAVFVDELDEVPDGSTVVFSAHGVSPAVRDEAARRGL
                     EVIDGTCPLVAKVHAEARRFAARGDTVVLVGHAGHEEVEGTMGEAPGSMVLVETAEEAR
                     ALPTADGRAVSYLTQTTLAVDETAEVVGALRETFPLLQEPPSDDICYATTNRQAALSAI
                     VAESDLVLVVGSENSSNSVRLVEMARRGGTRAELIDRAADIPEEWLDGVRTVGLTAGAS
                     APPALVTEVVTWLKGFGPVDVEEREITREDIHFDLPSAVRARPRPPADGRPS"
     source          1..21259
                     /country="China:southeast coast"
                     /db_xref="taxon:995841"
                     /isolation_source="Bruguiera gymnorrhiza"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sp. HKI0576"
                     /strain="HKI0576"
     subregion       1..21259
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000665"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..21259
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1015..2832
                     /gene="xiaB"
     CDS             1015..2832
                     /codon_start=1
                     /function="1-deoxy-D-xylulose-5-phosphate synthase"
                     /gene="xiaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DXP_synthase_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1110:1-deoxy-D-xylulose-5-phosphate synthase (Score:
                     254; E-value: 2.4e-77)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaB protein"
                     /protein_id="CCH63728.1"
                     /sec_met_domain="DXP_synthase_N (E-value: 6e-86, bitscore:
                     277.9, seeds: 174, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.8e-08, bitscore:
                     22.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSFSVLGRITGSEDLKGLHPDQLPALAGEIRDFLIEKVCATGGHL
                     GPNLGVVELTIALHRVFDSPVDRVVFDTGHQSYVHKLLTGRQAAFDSLRAAGGLSGYPL
                     REESEHDLVENSHASTALSYADGLAKAQRLLGEDHRRVVAVTGDGALTGGMAWEAMNNL
                     GSGGGSVIVVLNDNGRSYDPTVGGLAEHLTALRAGSHQGPNLFETMGFAYLGPVDGHDV
                     AAVEEAFRRAAGLTGPVVVHCVTEKGRGYVHAENDEADRMHGIGVVDSATGLPRGGGSP
                     SWTGTFGSEMERIGARRPDVVALTAAMLRPVGLHRFARSFPDRVFDTGIAEQHAVTSAA
                     GMAMAGLHPVVCLYATFLNRAVDQVMMDVALHGLPVTFVLDRAGVTGPDGPSHHGMWDL
                     SLLGTVPGMRVAAPRDPARLTELLEEALDIGDGPTALRFPKGGAGPEIPALGRMQGLDV
                     LHRTRSRPLDVLLVSAGVLAGTALGAAELLAAEGVGVTVVDPRWVLPVSPDLVHLAARH
                     RLTLSVEDGVRAGGVGAALAQACADARVPAPVHALGLPHAFLDHGERPDILAEHGLTAR
                     SVADTALALHHAAAPSPTPPAPRRERTPR"
     gene            2829..3980
                     /gene="xiaC"
     CDS             2829..3980
                     /codon_start=1
                     /function="4-hydroxy-3-methylbut-2-en-1-yl diphosphate
                     synthase"
                     /gene="xiaC"
                     /product="XiaC protein"
                     /protein_id="CCH63729.1"
                     /transl_table=11
                     /translation="MTQVALGMPASPPVTLADRRKTRQLQVGPVGVGSDHPVSVQSMTT
                     TVTADVNATLQQIAELTAAGCDIVRVACPSADDAEALPAIARKSKIPVIADIHFQPKYV
                     FAAIEAGCAAVRVNPGNIKKFDDKVGEIARAAKDHGTPIRIGVNAGSLDARLMRKYGKA
                     TPEALAESALWEASLFAEHDFHELKISVKHNDPVVMIRAYEILAEQCDYPLHLGVTEAG
                     PAFQGTVKSAVAFGALLRQGIGDTIRVSLSAPPVEEVKVGAQILQSLNLRPRKLEIVSC
                     PSCGRAQVDVYKLADEVTAGLEGMEVPLRVAVMGCVVNGPGEAREADLGVASGNGKGQI
                     FVKGEVVKTVPESKIVETLIEEALSLAETMDEQAGGSVTVVTG"
     gene            4412..5134
                     /gene="xiaD"
     CDS             4412..5134
                     /codon_start=1
                     /function="LuxR family transcriptional regulator"
                     /gene="xiaD"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 67; E-value:
                     2.3e-20)"
                     /gene_kind="regulatory"
                     /product="XiaD protein"
                     /protein_id="CCH63730.1"
                     /transl_table=11
                     /translation="MTANTQTEKTGPLPTGTRTTRTQTAGENPAKAAIRPAKVLVRAPD
                     PLTHSAISGQLATAPGIEVVAVGSTGPADVAVFVTERLTVDVTSTLRRLKSSLRIPVVL
                     IPSQIDRADLFTAVECNVVAVLPRVAATSERIRETVLTAASGGGVLPTKLLGELLRQFE
                     WMQREVLSPHGLHTSGLTPREIDVLRLMSEGLDTAEIAVRMCLSERAVKRVVFGVTQRL
                     NLRNRPHAVAYALRSGVI"
     misc_feature    4703..4705
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(5127..5879)
                     /gene="xiaE"
     CDS             complement(5127..5879)
                     /codon_start=1
                     /function="indolosesquiterpene cyclase"
                     /gene="xiaE"
                     /product="XiaE protein"
                     /protein_id="CCH63731.1"
                     /transl_table=11
                     /translation="MVWLPPFLIPMSEVPPVTVGAADVSDLLFAAVAGPTALGWMVTYV
                     LAIRQARRDGRTGIPAYLIAVNIAWEFSLTFLLEQTPTQRQINFLWLVFNVFLFAQALR
                     YGPRDYPGLSARTFRWTLAGVLVWASVVVMVGANELHDVDGMYTGMIIQVPLSAAFILM
                     LRRRGSSAGQSMHIAVAKTVGSLFAGLTAVIVYPSHHLLQVLVPTYVVLDVAYVVLLRR
                     TMLREGRPLWAFRHPGAGVPGGCRLPVR"
     gene            complement(5946..7145)
                     /gene="xiaF"
     CDS             complement(5946..7145)
                     /codon_start=1
                     /function="indole oxygenase"
                     /gene="xiaF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1191:acyl-CoA dehydrogenase type 2 (Score: 303.1;
                     E-value: 3.8e-92)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaF protein"
                     /protein_id="CCH63732.1"
                     /transl_table=11
                     /translation="MTMTDIRSETAELRAELVERVHKFGPVFADGVAEGERERRLPDAT
                     VRAIDQSQLAMLWTAKSYGGLETDVRTMSEVAKVLSHYCPSTSWVVNNVNGSNLLASKF
                     PRAALDEVFGDAPGAKLASVFAAAGTAVRTPGGYRLTGSWPYGTGILHDDWAILVAREV
                     DADGEPVGGLSMLVPARDLTVEDTWHTVGMRATGSHTVVLRDTFVPEHRVISGELQRSR
                     ESATDLGLPPLFRTAAIAAMAVVCASVVLGAGQAARALVVEKAPTRGIAPSKYTRQTDS
                     RTFVSSLGRTALSIDAAEMHVARAATALDDAAYDAVALPDSELLRIRGDVGQAVSLVTT
                     ALDELLWAHGAASFAESNPLQRYWRDANTAARHAMLNVHVGHELYGGSFFGLDPIVPSL
                     "
     gene            complement(7142..7531)
                     /gene="xiaG"
     CDS             complement(7142..7531)
                     /codon_start=1
                     /function="limonene-1,2-epoxide hydrolase"
                     /gene="xiaG"
                     /product="XiaG protein"
                     /protein_id="CCH63733.1"
                     /transl_table=11
                     /translation="MPSTDGERLVHTFLTSMGPTPADVRTAVETHLTDDCVWENPGSPV
                     CRGKAEILRLMPPDFARLKVRFGHLATAGETVLVERLEDMLRADGTHIARNLKVMGAFD
                     LRAGRIRAWRDYFDHTHLITDSPEW"
     gene            complement(7534..9327)
                     /gene="xiaH"
     CDS             complement(7534..9327)
                     /codon_start=1
                     /function="aromatic ring hydroxylase"
                     /gene="xiaH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 335.2; E-value:
                     1.2e-101)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaH protein"
                     /protein_id="CCH63734.1"
                     /transl_table=11
                     /translation="MMFDVEVPVLVVGGGGCGLAASVFLSDVGVRHLVVERRESTSVLP
                     RAHYLNQRTMEVFRQHGVADDVYGISCPLPNMSEIAWRTSLGGDGPADGRELHRMEAFG
                     GGGTAGPYAAHSTGPSTNLPQHRLEPLLRRHAERRAPGSLLFHHQMEEFTQDEHGVVAR
                     VTDRSTGEVGTVRARYLLGADGGRGVGDALGIRMDGAGGAFTIISVHFSADLSRWWSDP
                     VLMTHIFGLDGEVSVLVASGPDWGAASQEWALHFRVPPGTAAGGLDADTITGRVRELLK
                     LPADLGVRIHHVSEYRPEAVVARSFRSGRVFLAGDAAHRQPPAAGGGLNTAIQDVHNLA
                     WKLGAVLEGRAGDALLDSYEAERLPVARRNVGWAMGCLLNYGSLFAALGMAHGKPEATE
                     ASIRELLADTPMGETRRSVVREVFGTQRIEYQAHDIELGHHYASGAVVADGTPPPPRDP
                     WGAVHHPTTRPGHRLPHVWLRDGDARHSTHDLVPGDGGFLLLTGPLGEGWAAAAKKAAA
                     DHGVAITVVPVGGEPGAAGHRDTEGAWTGVRGVDDDGAVLVRPDQHVAWRSVRGSRRAD
                     HELGEVLDTVLGRSGAANGGC"
     gene            complement(9324..9557)
                     /gene="xiaI"
     CDS             complement(9324..9557)
                     /codon_start=1
                     /function="ferredoxin"
                     /gene="xiaI"
                     /gene_functions="other (smcogs) SMCOG1265:ferredoxin
                     (Score: 77.1; E-value: 1.4e-23)"
                     /gene_kind="other"
                     /product="XiaI protein"
                     /protein_id="CCH63735.1"
                     /transl_table=11
                     /translation="MKIEVDDTRCFAVGNCALHAPAVFDQNDEDGRVVVLDPAPSEQQY
                     AQVREAASRCPAAVIVLHEDAPDRPGTIPREE"
     gene            complement(9583..10752)
                     /gene="xiaJ"
     CDS             complement(9583..10752)
                     /codon_start=1
                     /function="cytochrome P450"
                     /gene="xiaJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 386.4; E-value:
                     2.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaJ protein"
                     /protein_id="CCH63736.1"
                     /sec_met_domain="p450 (E-value: 4.5e-14, bitscore: 41.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEPKTVPIGGRAAQCPFAPVAELYDTQKEDELSRVKVPSPMLGE
                     FDAVLVTRYDDVKDVLADEGLRMGGSMPYQPGNLLSYDGPEHTKLRRMLTASFTTKRAR
                     ELRPGIEAVVASSLDAVEEAGPGADLVQLFSTPIPTLVICELLGVPYTDREGFQRRTAL
                     ALDFTQSREVQMEKAAEMMAYMAQLVARHRENAGDNVLGRVVREYGDQLSDEELAGIGN
                     MLLIAGHETIANTLSSSIALLLQHPEQLAAVRDDPSVTDSAVEELLRYIAPATILPRQA
                     AGDICVRDQEIHKGEHVVPSVLAANRDLGTADQDLDSLDVRRPAQRHLTFGFGPHQCLG
                     QQLARMELRVALPALFTRFPTLRSAVPLDDLEYRTNALVFGVNALPVTW"
     gene            complement(10906..12036)
                     /gene="xiaK"
     CDS             complement(10906..12036)
                     /codon_start=1
                     /function="polyprenyl diphosphate synthase"
                     /gene="xiaK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 279.9; E-value:
                     3.5e-85)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaK protein"
                     /protein_id="CCH63737.1"
                     /transl_table=11
                     /translation="MRHATRQRGSGPPGKTPVPNPVPATPASYGRPVVRMTTTPVPGLT
                     AVLDTTRTLLEPALREAVATHLGPQMNRIARYHFGWSDAEGRPTGAWGGKMIRPNLALL
                     SARAAGAEAEDGLPAAVAIELVHNFSLLHDDIMDGDETRRGRATAWTVFGVPGAILAGD
                     ALVAAATCVLLAAPAAGARSATLALTAATRRMIDGQAADSEFERREDVTLAECVRMAGD
                     KTGALLGSACALGADLQGAEPRLVERLEAFGEHIGLAFQLVDDLLGIWGESAHTGKQVG
                     ADLRVRKKSLPVVAALNAPGTDELRALYLRPEPLTEPDIRRVTTLVERAGGRDWAQNEA
                     DRQIAAAEECLTAVDLPDDVHRAFTEVAGFVVGRRL"
     gene            complement(12059..14227)
                     /gene="xiaL"
     CDS             complement(12059..14227)
                     /codon_start=1
                     /function="indole-farnesyl epoxidase"
                     /gene="xiaL"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1246:monooxygenase FAD-binding (Score: 448.4; E-value:
                     4.4e-136)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaL protein"
                     /protein_id="CCH63738.1"
                     /transl_table=11
                     /translation="MTSPNYATYLHLPELLDLQRPLTPVDQQDLSDSERLFIVVHQASE
                     TLLSQVLVDLRHIASGQCGRRCHDRRAQRATRLVGALEGQLKLLHHTLPREDFLLFRHR
                     FGTASGVQSKQFHELFARVRKLTKHGDEDGPAADPELLTALDEAVRRWRHTHIELVAHM
                     LGDRPGSAETSGLRWLAARLDGSSDTASYTASYGSSGTISYGSSDTASGTASYNAEPSA
                     AEQQGACPVAGGRRSTGQQAAGPEAEGPRATEPPTAERQPVTAPRRAAAAGGLGHVVVV
                     GGSVAGLLTAHVLAGHAERVTVLERDQYEDTPGPRAGVPQSRHTHVLLTSGMNALEELL
                     PGLLPALEDAGAPRLAVPGDLGVWQAGQWISRRNPSRPIMTPSRPLLEHHVRRRVLDDP
                     RVHVRTGVEVTGLLGRPGHITGVAVRTRGGDHPARQEIEADLVVDASGRASRTPAWLAD
                     LGAPAPAEELVETGRAYATCVFHADHPPEDLDGFYIVPDAGQPLGAIVLPVEGDRWMVT
                     LSGPRGEAPPGDAEGFVEFAGRLPHSAPHKWLRSARPVGRPAGYRHTANRRRRYDRPGQ
                     HNTGLLVVGDAACALNPVYGQGLSVAALNAVALREELAGKRAVPSRTLQRAVFRSARRA
                     WDVATGADSPMPGVTGNAVRSGPAARLLTRYLDRVRAHVPHDPVVCGTQRDVLFLLAPP
                     RTLVTSPRVLRRALLSPAGPDRSAPPTP"
     gene            complement(14256..15263)
                     /gene="xiaM"
     CDS             complement(14256..15263)
                     /codon_start=1
                     /function="polyprenyl transferase"
                     /gene="xiaM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 193.6; E-value:
                     6.8e-59)"
                     /gene_kind="biosynthetic-additional"
                     /product="XiaM protein"
                     /protein_id="CCH63739.1"
                     /transl_table=11
                     /translation="MPSVERMTEIDVPRVADRELAAIVGAEVEDRWPNDVSGLDEIVRY
                     GLVPFGKMMGPWLVTHSALAVGGDLPTVLPAAVAVECVQVGAMMHDDIIDDDGERRSKP
                     AAHTVYGQPTAIVGGDGLFFHGFAALAECQEAGAPAERVAQALVVLSKAGLRIGDAAIR
                     EIRMSREVCSVDDYLGMIADKSGALLWMACGVGATLGGGNDKDLRALSQYSDRLGIAYQ
                     IRDDLMAYDGTRAGKPNVSDVRNGRPTLPVLLAHERAPVAEQQHIERLLADTAVPVEER
                     YAAMARLVHDHDGVAAAREVSHRYVDMAAAALESLLPGVHRDALADLTVPGRLV"
     gene            complement(15358..18309)
                     /gene="xiaN"
     CDS             complement(15358..18309)
                     /codon_start=1
                     /function="transcriptional regulator"
                     /gene="xiaN"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 88.7; E-value: 4.8e-27)"
                     /gene_kind="regulatory"
                     /product="XiaN protein"
                     /protein_id="CCH63740.1"
                     /transl_table=11
                     /translation="MARTRAAVRGRDQELTALRTALAPDGGRLIVLTGPAGIGRTALLD
                     SVARLLAADGARVLPLRLGTGPDGGGDPYALAALVRAVRERFEQLQESGLSEALSAVAQ
                     LRDARGRERGGWTPAVVAALDGLFETVGRRERVALLVDDAHAVAEPAPVLSAARRAGCL
                     VVATCEEGAERGPGLAELLTDADRVMTIGPLADDVALSLVRRAAGARLDESVVTALRTA
                     LGPLLGNPGTVLGTLDALRRSGRLVTFEGRLCLSDPAEPVALPADHPLLRRASALGGTA
                     VRLLGAVALLDGLDLDALPPLADILEADPVDCGRGLDLLIEAGVLTAGPDGRIACRCPA
                     LAATAAGRFRARRGTALHAALAERLLAGHRRSGGVDPVVLADHVARGGATVTLDDDTVR
                     QLLTMGAAAEQEEPERATLWYAAALRRLPPTGPEHARTLCRLLLLVVRTGRYELLREPL
                     TRYAEHGCAEESVDEIRLAAILLALHSGVPPAERAVRELLDAPFPGRGPTAFSEWWFDR
                     RLAPDPRRHPATDGDTVARCGCGCGAVRCGAGAGAGTRAGPSRGGGQKSRQRPGRDGGE
                     AETPAGARLRWGAVPVTDRSRAVARDGTAAGDGARGGAGRSDLLSAALCGDVAACERVW
                     RSSGGAAPSPELDRVAPGRLVADMADVARLVIGADYRVPETGVLGAYHRVVRGYADADW
                     TRAMSAVRELELSPAEDTLARHAARLLAVDMCAARGEFGQASRWLTAATRAPRLAVLRT
                     WARVGLAARKGDDGQAVRVALLAGPRLRRAGLRTGLSILLSRALRIAVLGDDHEGAAEL
                     LAEIELLPHEHHVDAQESLLLARGLVHRDPECAREATDLIRERGDLPALMESCLAVARF
                     APDPRPWLREAHALATRCGAAALLERVREVTRERGVPAPRARGRRDALAVTEQRIIELI
                     GEGLTNRQIALRLRLSEKTVENYLTRLFARTGCRSRVELAAASLTGRLARTPT"
     gene            18482..21259
                     /gene="xiaO"
     CDS             18482..21259
                     /codon_start=1
                     /function="transcriptional regulator"
                     /gene="xiaO"
                     /gene_functions="regulatory (smcogs) SMCOG1149:LuxR family
                     transcriptional regulator (Score: 121.3; E-value: 7.1e-37)"
                     /gene_kind="regulatory"
                     /product="XiaO protein"
                     /protein_id="CCH63741.1"
                     /transl_table=11
                     /translation="MIDHWRDAPDAARSAPAPFGRDAVVAHVAELAVSSDAAPLVLVTG
                     PIGMGRSSLLAAVRAELTARGFTPLSLRVARNERDRPYSLASRLCAEIAALRSGDARRT
                     ARATAVVSLGEAGRQLAAELRSALTVNDKLTVLIDDAHWADPASRAVLLSLTRALAGGP
                     VTVVCTVRPSPADPASERAVLEQLRAASLAEVVPLRPLGEQEVAALIAHTLQARPTAAL
                     LSSLQRECRGRPAAVLAAVAGHLRTGGLQVYDRHVYLTSPDRPPELPLDLPPIEYLRRL
                     GGTVWAVAKAAAVMLPLGTAATGLIARAVGRDEEEVRGALSELSVEGVLRQETEDGRWR
                     FRLPLLASALTGCLGPWERRSLARLAVTAIWAGDAVADDRYLADQLVVAGRSVDARRAA
                     GELLARGTAAMLDDGYCAERWLRAAAELATEPRQRARVLVAHATTCCLQLRFAEAIDSA
                     GKVLSEYAEDHVDSATLLEIQLAYVVALAGTLDTAALTELCDGGWRSLPGRQWHRVVTR
                     CIALCHLDRWREADEHLALLRHVWHRDDDVFAGLGLLVSECTGAYMGRFEPFEQAVADP
                     TDWPLWASGPRFRFERLWQLARVLMAFGEQERADRLLAAHDPPSAYRTLPDQVVADSQS
                     GHWDRALDTARLGLATGLSVGYAPSHTLVSRETSVILGARGRLTEARAVIERARSVQPV
                     MLHLLAVAESCLDEALGDVEGALDVVARGLALAADRGLVVGTDVLWLRSAGLELARGDR
                     AAARRAVAETGRTAELTGTGRARLCHLLATATVEGDRAAAAEAIGLARQRAQPLELADT
                     LTLAVRHEVADSGLLHEAYALYGGLDALLRRAQLRNLMRARGVTVPHRAVVTAENERLL
                     ATLVTEGLTNRELAAALGSSEKSVESRLGRLFKRTGYRSRVELASAMLTDDYRA"
ORIGIN
        1 gtgactgatg tgagctcgga tacgtacgcg ggcagcgggg tacgccgtcg cgtcctgctg
       61 gccggtcccc ggtccttctg cgcgggtgtc gaacgggcca tcgagatcgt cgagcgggcg
      121 ctggaatccc gcggcgcccc cgtctacgtc cgcaagcaga tcgtgcacaa cgtcaccgtc
      181 gtcgacgatc tggcggatcg tggcgcggtg ttcgtcgacg aactggacga ggtgcccgac
      241 ggctcgacgg tggtcttctc cgcacacggg gtctcgcccg cggtgcgcga cgaggcggcc
      301 cggcgcggtc tggaggtgat cgacggaacc tgtcccctgg tcgccaaggt gcacgcggag
      361 gcgcgccgtt tcgccgcccg gggcgacacc gtcgtcctcg tggggcacgc cggacacgag
      421 gaggtcgagg gcaccatggg cgaggcgccc gggtccatgg tgctggtcga gacggcggag
      481 gaggcgcgcg cgctcccgac ggccgacggg cgggccgtgt cgtacctcac ccagaccacg
      541 ctggccgtcg acgagaccgc ggaggtcgtc ggggcgctgc gggagacgtt cccgctgctc
      601 caggagccgc cgtcggacga catctgctac gccaccacca accggcaggc cgcgctctcg
      661 gcgatcgtcg cggagtcgga cctcgtcctg gtcgtcgggt cggagaactc ctccaactcg
      721 gtacggctgg tggagatggc gcgccgcggg ggcacccggg ccgagctgat cgaccgggcc
      781 gcggacatcc ccgaggagtg gctggacggg gtgcggacgg tggggctgac ggccggcgcc
      841 tcggcgccgc ccgccctggt gacggaggtg gtgacgtggc tgaagggctt cggcccggtc
      901 gacgtcgagg aacgcgagat cactcgcgaa gacatacatt tcgaccttcc ctcggcggta
      961 cgcgctcggc cgcgtccgcc ggcggacggc cgccccagct gagcgaggcg agacgtgtca
     1021 ttctctgtgc tcggccggat caccggctcc gaggacctca aagggctgca cccggaccaa
     1081 ctgcccgccc tggcgggcga gatccgggac ttcctgatcg agaaggtgtg cgcgaccggc
     1141 ggacacctcg gtccgaacct cggtgtggtg gagctgacca tcgcgctgca ccgggtgttc
     1201 gactcccccg tggaccgcgt ggtgttcgac accggccacc agtcctacgt ccacaagctg
     1261 ctcaccggcc ggcaggccgc cttcgactcg ctgcgcgcgg ccgggggcct gtccggctac
     1321 cccctgcgcg aggagtccga gcacgatctg gtggagaact cgcacgcctc caccgcgctg
     1381 tcctacgcgg acggcctggc caaggcccag cggctgctcg gtgaggacca ccgccgcgtg
     1441 gtcgcggtca ccggggacgg cgcgctgacc ggcggcatgg cctgggaggc gatgaacaac
     1501 ctgggcagcg gcggcggttc ggtgatcgtc gtactcaacg acaacggccg ctcctacgat
     1561 cccaccgtcg gtgggctggc cgagcacctg accgccctgc gggccggttc ccaccagggg
     1621 cccaacctct tcgagaccat gggcttcgcc tacctcggtc cggtggacgg gcacgacgtc
     1681 gccgccgtcg aggaggcgtt ccgccgggcg gcggggctga ccggcccggt cgtcgtccac
     1741 tgcgtcaccg agaagggccg ggggtacgtc cacgccgaga acgacgaggc cgaccgcatg
     1801 cacggcatcg gcgtcgtcga ctccgccacg ggccttccgc ggggcggcgg ttcgccctcg
     1861 tggacgggca ccttcggctc ggagatggag cggatcggcg cgaggcgtcc cgacgtcgtc
     1921 gcgctgaccg cggcgatgct gcggccggtc ggactgcacc ggttcgcccg gagcttcccg
     1981 gaccgggtct tcgacaccgg catcgccgag cagcacgcgg tcaccagtgc cgcggggatg
     2041 gccatggccg ggctgcaccc cgtggtgtgc ctgtacgcca cgttcctcaa ccgggccgtg
     2101 gaccaggtca tgatggacgt ggccctgcac gggctgccgg tgaccttcgt cctggaccgg
     2161 gcgggcgtca ccggtcccga cggtcccagc caccacggca tgtgggacct ctccctgctg
     2221 ggcacggtgc cgggcatgcg ggtcgccgcg ccccgggacc ccgcccgcct cacggaactg
     2281 ctggaggagg cgctggacat cggggacggc cccaccgcgc tgcgcttccc gaagggcggc
     2341 gcggggccgg agatcccggc gctgggccgg atgcagggcc tggacgtact gcaccgcacc
     2401 cggtcacggc cgctggacgt gctgctcgtc agcgccgggg tgctcgcggg tacggcgctg
     2461 ggcgcggcgg agctgctcgc cgccgagggc gtcggggtca cggtcgtcga cccgcgctgg
     2521 gtcctgccgg tctcccccga cctggtccat ctggccgccc ggcaccggct gaccctgtcc
     2581 gtcgaggacg gggtgcgtgc cggcggggtg ggcgccgccc tggcacaggc gtgcgccgat
     2641 gcccgggtgc cggcgccggt gcacgccctg gggctgccgc acgccttcct cgaccacggc
     2701 gagcggccgg acatcctcgc cgaacacggc ctcaccgcgc ggtccgtcgc cgacaccgcg
     2761 ctcgcgctgc accatgccgc ggcgccatcc cccacaccac cggcaccccg tcgggagagg
     2821 actccacggt gacccaggtc gcgctcggaa tgcccgcttc gccgcccgtc acgctcgccg
     2881 accgccgcaa gacccgccag ttgcaggtcg ggccggtcgg tgtgggcagt gaccatcccg
     2941 tgtcggtgca gtcgatgacg acgaccgtca cggccgacgt caacgccacc ctccagcaga
     3001 tcgccgaact caccgccgcg ggctgcgaca tcgtgcgggt cgcctgcccg agcgcggacg
     3061 acgccgaggc gctgcccgcg atcgcccgca agtcgaagat cccggtgatc gccgacatcc
     3121 acttccagcc gaagtacgtc ttcgcggcga tcgaggccgg ctgtgcggcg gtgcgggtca
     3181 acccgggcaa catcaagaag ttcgacgaca aggtgggcga gatcgcccgc gccgccaagg
     3241 accacggcac cccgatccgg atcggggtga acgccgggtc gctggacgcg cgcctgatgc
     3301 gcaagtacgg gaaggccact ccggaggcgc tggccgagtc ggcgctgtgg gaggcgtcgc
     3361 tcttcgccga acacgacttc cacgagctga agatctcggt caagcacaac gaccccgtgg
     3421 tcatgatccg cgcctacgag atcctcgccg agcagtgcga ctacccgctg cacctgggcg
     3481 tcaccgaggc ggggccggcg ttccagggca ccgtcaagtc cgccgtggcc ttcggggcgc
     3541 tgctgcgcca gggcatcggc gacaccatcc gggtctccct ctcggcgccg ccggtggagg
     3601 aggtcaaggt cggcgcgcag atcctgcagt cgctcaatct gcggccccgc aagctggaga
     3661 tcgtctcctg cccctcgtgc ggccgggcgc aggtggacgt ctacaagctc gccgacgagg
     3721 tcaccgccgg cctggagggc atggaggtgc ccctgcgggt cgccgtgatg gggtgcgtgg
     3781 tcaacggccc cggcgaggcg cgcgaggccg acctcggagt ggcgtccggc aacggcaagg
     3841 ggcagatctt cgtcaagggc gaggtcgtca agaccgtccc cgagtcaaag atcgtcgaga
     3901 ccctcatcga ggaggcgctg agcctcgccg agacgatgga cgagcaggca ggaggctccg
     3961 tcacggtcgt caccggttga atgagggatt ccccttaggg gaacgaaaag gggtcgctca
     4021 cccggctccc cgaagtggac cacagtaagg tcattcacgt cgcttttccg actgtcaatg
     4081 accactgaag gccactttcg gggagctttg acgtgcttgc cgtacacgcg cttgacgtac
     4141 ccgtgcctgc cgtaccagtg cttgcagtac ccgtggttgc cgtacccgtg gttgccgtac
     4201 ccgtgcctga cgcacaggcg ctcgccgtac acggggcacc actggacgcg tccctcggcg
     4261 gtccgtccgc ccggccctgt tgctgaccgg gccggccgca cggacggaga aagaagcaca
     4321 gcgatcaccg gctcgggcac cgccatgccc ggaaccggcc tcgggacgga catgctccgg
     4381 ccatagcgcc gactgttttc ggaggcttgc catgactgcc aacacccaga cggagaaaac
     4441 cgggccgctc cccaccggga cgcggaccac gaggacgcag accgccggag agaaccccgc
     4501 caaggccgcg atccggccgg cgaaggtcct ggtcagggca ccggatccgc tgacgcactc
     4561 ggcgatcagc ggtcagctcg ccaccgcgcc gggcatagaa gtggtcgcgg tggggagcac
     4621 cggcccggcc gacgtggccg tgttcgtcac cgagcgcctg accgtggacg tcacctcgac
     4681 cctgcgcagg ctgaagagct ccttacggat accggtggtg ctcatcccgt cgcagatcga
     4741 ccgcgcggac ctcttcaccg cggtggagtg caacgtggtc gcggtcctgc cgcgggtcgc
     4801 cgccaccagc gagcgcatcc gggagacggt gctgaccgcc gcgtccggcg gtggcgtgct
     4861 ccccacgaag ctgctgggcg aactgctccg gcagttcgag tggatgcagc gcgaggtcct
     4921 gtcaccgcac ggcctgcaca cctccgggct gactccccgg gagatcgacg tcctgcggct
     4981 gatgtcggag gggctggaca ccgccgagat cgccgtccgg atgtgcctgt cggaacgggc
     5041 ggtcaaacgg gtcgtcttcg gggtcaccca gcgcctcaac ctgcgcaacc ggccgcacgc
     5101 ggtggcctac gccctacgca gtggcgtcat ctgaccggga gccggcaccc gcccgggaca
     5161 ccggcgcccg ggtggcggaa ggcccacagc ggccgtccct cgcggagcat cgtccggcgc
     5221 agcagcacca cgtaggcgac gtccaggacg acgtaggtcg gcaccagcac ctgcagcagg
     5281 tggtgggagg gatagacgat cacggcggtc aggccggcga agagggaccc cacggtcttg
     5341 gcgaccgcga tgtgcatcga ctggcccgca ctggatccgc gccgcctgag catgaggatg
     5401 aacgcggcgc tcagcggcac ctggatgatc atgccggtgt acatgccgtc gacgtcgtgc
     5461 agctcgttgg cgccgaccat gacgacgacc gacgcccaca ccagcacacc ggcgagcgtc
     5521 caccggaagg tgcgcgcgga gaggccgggg tagtcgcgcg gcccgtaccg cagggcctgg
     5581 gcgaacagga agacgttgaa gaccagccac aggaagttga tctgccgctg ggtcggtgtc
     5641 tgctccagca ggaaggtcag gctgaactcc caggcgatgt tcaccgcgat gaggtacgcg
     5701 ggtatccccg tgcgcccgtc ccggcgggcc tgccggatcg ccaggacgta cgtcaccatc
     5761 cagcccagcg cggtcggtcc ggcgacggcc gcgaagagca ggtccgagac gtcggccgcc
     5821 cccaccgtca cgggcgggac ctccgacatc gggatgagaa aggggggcag ccagaccatg
     5881 ggggatccct cgtgggtcgg gtcggaaggg gaggtgcctg aaggagggcg gcgcgggagg
     5941 gggtctcaga ggctgggcac gatggggtcg agaccgaaga aggaaccgcc gtacagctcg
     6001 tggccgacgt gcacgttgag catcgcgtgg cgggccgcgg tgttggcgtc ccgccagtac
     6061 cgctgcagcg ggttcgactc ggcgaaggac gccgccccgt gggcccacag cagttcgtcg
     6121 agggcggtgg tcaccaggct caccgcctgg cccacgtcgc cgcggatgcg caggagttcg
     6181 ctgtccggca gcgcgacggc gtcgtacgcg gcgtcgtcga gggcggtcgc ggcccgtgcc
     6241 acgtgcatct cggcggcgtc gatcgacagg gcggtgcggc cgagcgagga cacgaacgtc
     6301 cgtgagtccg tctgacgggt gtacttggag ggcgcgatcc cccgcgtcgg cgccttctcc
     6361 acgacgaggg cgcgggccgc ctggccggcg ccgagcacca cggaggcgca gacgacggcc
     6421 atggcggcga tcgccgccgt acggaacagg ggtggcaggc cgaggtcggt ggcgctctcc
     6481 cggctgcgct gcaactcgcc gctgatcacc cggtgttcgg ggacgaacgt gtcccgcagg
     6541 acgacggtgt ggctgccggt ggcccgcatg ccgacggtgt gccaggtgtc ctcgacggtc
     6601 aggtcccggg ccggcaccag catggagagc ccgccgaccg gctccccgtc ggcgtccacc
     6661 tcccgcgcga ccaggatcgc ccagtcgtcg tgcaggatgc cggtgccgta cggccaggag
     6721 cccgtcagcc ggtagccgcc gggggtgcgt accgctgtgc ccgcggccgc gaagaccgac
     6781 gccagtttgg cgccgggggc gtccccgaac acctcgtcca gcgccgcccg cgggaacttc
     6841 gaggcgagca ggttggagcc gttgacgttg ttgaccaccc aggaggtgga cgggcagtag
     6901 tgggagagga ccttggccac ctcgctcatg gtccgcacgt cggtctccag gccgccgtag
     6961 gacttcgcgg tccacagcat ggccagttgg gactggtcga tggcgcggac cgtggcgtcg
     7021 ggcagccgtc gctcccgctc cccctcggcg acgccgtccg cgaagaccgg gccgaacttg
     7081 tggaccctct ccacgagttc ggcccgcagt tccgccgtct ccgatcggat gtctgtcatg
     7141 gtcaccactc cgggctgtcg gtgatgaggt gggtgtggtc gaagtagtcc cgccaggcgc
     7201 ggatccgtcc ggcccgcagg tcgaaggcgc ccatcacctt caggttgcgc gcgatgtggg
     7261 tgccgtcggc gcggagcatg tcctccaggc gttcgacgag gacggtctcc ccggccgtgg
     7321 ccaggtgccc gaacctcacc ttcaggcgcg cgaagtcggg cggcatgagc cggaggatct
     7381 ccgccttgcc ccggcacacc ggggagccgg ggttctccca cacgcagtcg tcggtgaggt
     7441 gggtctccac ggccgtgcgg acgtcggccg gggtcggccc catcgatgtc aggaaggtgt
     7501 ggacgaggcg ctcgccgtcg gtcgagggca tggtcagcac ccgccgttcg ccgcgccgga
     7561 gcggccgagc acggtgtcga ggacctcgcc cagttcgtgg tcggcgcggc ggctgccccg
     7621 cacgctgcgc caggcgacgt gctggtcggg ccgtacgaga acggcgccgt cgtcgtcgac
     7681 gccccgcacc ccggtccagg cgccctcggt gtcccggtgg cccgccgcgc cgggttcgcc
     7741 gccgacgggc accacggtga tcgccacccc gtggtcggcg gcggccttct tggcggccgc
     7801 cgcccagccc tcgcccagcg gaccggtgag caggaggaaa ccgccgtcgc cggggaccag
     7861 gtcgtgcgtg gagtgccggg cgtcgccgtc ccgcagccac acgtgcggga gccggtgccc
     7921 cgggcgggtc gtcgggtggt gcaccgcgcc ccacgggtcg cggggcggcg gcggggtgcc
     7981 gtccgcgacg acggcgccgg aggcgtagtg gtggccgagc tcgatgtcgt gtgcctggta
     8041 ctcgatgcgc tgggtgccga acacctcccg gaccacggac cgccgggtct cgcccatcgg
     8101 ggtgtcggcg aggagctcgc ggatactggc ctcggtggcc tccggtttcc cgtgcgccat
     8161 gccgagggcc gcgaagaggg aaccgtagtt gagcagacag cccatcgccc agccgacgtt
     8221 gcgccgggcg acgggcagcc gctccgcctc gtaggagtcg agcagcgcgt cgccggcccg
     8281 gccctccagc acggccccga gcttccaggc gaggttgtgg acgtcctgga tcgccgtgtt
     8341 gaggccgccg cccgcggcgg gcggctgccg gtgtgccgcg tcaccggcga ggaagacgcg
     8401 gccggagcgg aacgagcggg ccacgaccgc ctccggccgg tactcgctca cgtggtggat
     8461 ccgtaccccg aggtccgcgg gcagcttcag cagctcccgg acgcggcccg tgatcgtgtc
     8521 cgcgtcgagg ccgcccgccg ccgtgccggg cggcacccgg aagtgcaggg cccactcctg
     8581 ggacgcggca ccccagtcgg gcccggaggc gacgagtacc gagacctcgc cgtcgaggcc
     8641 gaagatgtgc gtcatcagca ccgggtcgct ccaccagcgg gagaggtcgg cgctgaagtg
     8701 cacggagatg atggtgaagg cgccgcccgc gccgtccatc cggatgccga gcgcgtcccc
     8761 gacgccgcgg ccgccgtcgg ctcccagcag gtaccgggcg cgtacggtgc ccacctcgcc
     8821 ggtgctccgg tcggtcaccc gggccacgac cccgtgctcg tcctgcgtga actcctccat
     8881 ctggtggtgg aagagcaggc ttccgggcgc ccggcgctcc gcgtgccggc gcagcagcgg
     8941 ttcgagccgg tgctgcggga ggttggtgga gggcccggtg ctgtgggcgg cgtagggtcc
     9001 ggcggtgccg cctcccccga aggcctccat ccggtgcagt tcacgcccgt ccgcgggacc
     9061 gtcgccgccg agcgaggtgc gccaggcgat ctcgctcatg ttcggcagcg ggcagctgat
     9121 cccgtacacg tcgtcggcga cgccgtgctg gcggaacacc tccatggtgc gctggttcag
     9181 gtagtgcgcc ctgggcagga cggacgtcga ctcgcgccgc tccaccacca ggtgccgcac
     9241 cccgacgtcg gacaggaaca ccgacgcggc gagcccgcag ccaccgccgc cgaccacgag
     9301 gaccggcact tctacgtcga acatcactct tccctcggga ttgtgccggg ccggtccggg
     9361 gcgtcctcgt gcaggacgat gaccgcggcc ggacaccgcg aggccgcctc ccggacctgt
     9421 gcgtactgct gctcggacgg ggcggggtcg agtacgacca ccctgccgtc ctcgtcgttc
     9481 tggtcgaaga ccgccggcgc gtgcagggcg cagttgccga cggcgaagca cctggtgtcg
     9541 tcgacctcga tcttcatggg tggctccctc tcccgccgcc ggtcaccagg tgaccggcag
     9601 ggcgttgacg ccgaagacca gggcgttggt gcggtactcc aggtcgtcga gcgggaccgc
     9661 cgagcgcagc gtggggaacc tggtgaacag ggcgggcagc gcgacccgca gttccatgcg
     9721 ggccagttgc tggcccaggc actggtgcgg gccgaagccg aaggtgaggt ggcgctgcgc
     9781 ggggcggcgc acgtcgaggc tgtccaggtc ctggtcggcg gtgccgaggt cgcggttggc
     9841 ggccagcacg gacggcacga cgtgctcgcc cttgtggatc tcctggtcgc gcacgcagat
     9901 gtccccggcg gcctggcgcg gcaggatggt ggccggggcg atgtagcgca gcagctcctc
     9961 cacggcgctg tcggtcaccg aggggtcgtc gcgcacggcc gcgagctgct cggggtgctg
    10021 gagcagcagc gcgatgctgg aggagagggt gttggcgatc gtctcgtgcc cggcgatgag
    10081 cagcatgttg ccgatgccgg ccagctcctc gtcgctcagc tggtcgccgt actcgcgcac
    10141 cacgcggccc agcacgttgt cgcccgcgtt ctcccggtgc cgggccacga gttgggccat
    10201 gtaggccatc atctcggcgg ccttctccat ctggacctcg cggctctggg tgaagtccag
    10261 tgcgagggcg gtacggcgct ggaagccctc gcggtcggtg tagggcacgc cgaggagttc
    10321 gcagatgacg agcgtcggga tcggggtgct gaagagctgc accaggtcgg cgcccggacc
    10381 ggcctcctcg accgcgtcca gcgaggacgc gaccacggcc tcgatgcccg gccgcagctc
    10441 gcgcgcccgt ttggtggtga acgacgcggt cagcatccgc cgcagtttgg tgtgttcggg
    10501 gccgtcgtag ctcagcaggt tgccgggctg gtacggcatg gagccgccca tccgcaggcc
    10561 ctcgtcggcg agtacgtcct tgacgtcgtc gtaccgggtg acgagcaccg cgtcgaactc
    10621 gcccagcatc gggctgggca ccttgacgcg gctgagctcg tcctccttct gcgtgtcgta
    10681 cagctcggcg acgggggcga acgggcactg ggcggcccgt ccgccgatgg ggacggtctt
    10741 cggctcggtc atggggcggc cttcctgatg agggcggaag cggacgggcg gagggggagg
    10801 tgccggtgcg gacccgcgtc ggcgggcgtg cggaggcgga cgggcggatc ggtggtgggc
    10861 ggcgcgtcgg gcgccgcctg ccgtgcgggg cgcgggcccg cggagctaca ggcggcggcc
    10921 gacgacgaac ccggcgacct ccgtgaacgc gcggtgcacg tcgtccggga ggtcgacggc
    10981 ggtcaggcac tcctcggccg cggcgatctg ccggtccgcc tcgttctgtg cccagtcccg
    11041 tccgcccgcc cgttcgacga gcgtggtgac ccgccggatg tcgggttcgg tcagcggctc
    11101 cggtcgcagg tacagggcgc gcagctcgtc cgtcccgggc gcgttcaggg ccgccaccac
    11161 gggcagggac ttcttgcgga cccgcaggtc ggcccccacc tgtttgccgg tgtgcgcgga
    11221 ctcgccccag atgcccagca ggtcgtcgac gagctggaag gcgagcccga tgtgctcgcc
    11281 gaaggcttcg agccgttcga ccaggcgcgg ttcggcgccc tgcaggtcgg cgccgagcgc
    11341 gcaggcgctg cccagcaggg cgccggtctt gtcgccggcc atgcggacgc actcggcgag
    11401 ggtcacgtcc tcgcgccgct cgaactcgga gtcggcggcc tggccgtcga tcatccgccg
    11461 ggtcgcggcc gtcagcgcca gggtggcgga acgggcgccc gcggccggtg cggccagcag
    11521 gacgcacgtc gcggcggcga ccagggcgtc accggccagg atggcgcccg gcacgccgaa
    11581 gacggtccag gcggtggccc ggccccgccg ggtctcgtcg ccgtccatga tgtcgtcgtg
    11641 cagcagcgag aagttgtgca cgagttctat ggcgaccgcg gcgggcagtc cgtcctcggc
    11701 ctcggcaccg gccgcgcggg ccgagagcag ggccaggttg ggccggatca tcttgccgcc
    11761 ccaggcaccg gtcgggcgcc cctcggcgtc ggaccagccg aagtggtagc gggcgatcct
    11821 gttcatctgc gggcccaggt gcgtggcgac ggcctcgcgc agggcgggtt cgaggagggt
    11881 ccgggtggtg tcgaggaccg cggtcaggcc ggggaccggc gtcgtcgtca tgcggaccac
    11941 cggccgcccg tacgacgcag gggtggccgg gaccgggttc ggaaccggtg tcttcccggg
    12001 cggtccggat ccacgctgac gtgtcgcatg gcgcaccttc gctgtcggct cgtgacggtc
    12061 atggagtggg gggcgcggac cggtcgggcc cggccgggct cagcagggcc cgccgcagca
    12121 cccgggggga ggtgacgagc gtgcggggcg gggccagcag gaagaggacg tcgcgctggg
    12181 tgccgcagac gaccgggtcg tggggcacgt gcgcgcgcac ccggtcgagg taccgggtca
    12241 gcagccgcgc ggcgggcccg gagcgcaccg cgttgccggt gacgcccggc atggggctgt
    12301 cggcgcccgt cgcgacgtcc caggcgcggc gggcggagcg gaacaccgcc cgttgcaggg
    12361 tgcgggacgg gacggcgcgc ttcccggcca gttcctcgcg gagggcgacc gcgttcaggg
    12421 cggcgacgga caggccctgt ccgtagacgg ggttgagcgc gcacgccgcg tccccgacga
    12481 cgagcagtcc ggtgttgtgc tgccccgggc ggtcgtagcg gcggcgccgg ttggcggtgt
    12541 gccggtagcc cgcgggccgc ccgaccgggc gtgccgagcg gagccacttg tgcggcgcgg
    12601 agtgcggcag gcggcccgcg aactcgacga agccctcggc gtcgccgggc ggtgcctcgc
    12661 cgcgcggccc cgacagggtg accatccagc ggtcgccctc gacgggcagg acgatcgcgc
    12721 cgagcggctg gccggcgtcg gggacgatgt agaagccgtc gaggtcctcg ggcgggtggt
    12781 cggcgtggaa gacgcaggtg gcgtaggccc gtccggtctc cacgagttcc tcggcgggtg
    12841 ccggggcgcc caggtcggcc agccacgcgg gggtgcggct ggcccggccg gaggcgtcca
    12901 ccacgaggtc ggcctcgatc tcctgccggg cggggtggtc gccgccgcgg gtgcggaccg
    12961 cgacgccggt gatgtgtccg gggcggccga gcaggccggt cacctcgaca ccggtgcgga
    13021 cgtggacccg ggggtcgtcc aggacgcgtc ggcggacgtg gtgttccagg agcgggcggg
    13081 agggggtcat gatcggccgg gacgggttgc ggcgcgatat ccactggccc gcctgccaca
    13141 cgccgaggtc gccggggacc gcgagccgcg gtgcccccgc gtcctccagt gcgggcagca
    13201 ggccgggcag cagttcctcc agggcgttca tgccgctggt gagcaggacg tgggtgtggc
    13261 gcgactgggg caccccggcg cgcgggcccg gagtgtcctc gtactggtcg cgttcgagca
    13321 ccgtcacccg ttcggcgtgg ccggccagga cgtgcgcggt cagcagcccc gcgacgctgc
    13381 cgcccacgac gaccacgtgc ccgaggccgc cggctgcggc ggcccgccgg ggcgcggtga
    13441 cgggttgccg ttcggcggtg gggggttcgg tggcccgggg gccctcggcc tcgggtccgg
    13501 cggcctgttg cccggtggac cggcgtcccc cggccacggg gcaggcgccc tgctgttcgg
    13561 cggcgctcgg ttcggcgttg taggaggcgg tgccggaagc ggtgtcggag ctgccgtagg
    13621 agatggtgcc ggagctgccg taggaggccg tgtaggaggc ggtgtcggag ctgccgtcca
    13681 gccgggcggc cagccagcgc agtccggagg tctcggccga gcccggccgg tcgccgagca
    13741 tgtgggcgac cagttcgatg tgggtgtgcc gccagcgccg tacggcttcg tccagcgccg
    13801 tcagcagctc cggatcggcc gcggggccgt cctcgtcacc gtgcttcgtc agcttccgca
    13861 cccgggcgaa cagttcgtgg aactgcttcg actgcactcc gctcgccgtg ccgaaccggt
    13921 gccggaagag caggaagtcc tcccgcggca gcgtgtggtg cagcagcttc agctgtcctt
    13981 ccagggcgcc caccagccgc gtcgcccgct gggcgcgccg gtcgtggcac cgccgtccgc
    14041 actgcccgga ggcgatgtgc cgcaggtcga ccagcacttg gctgagcagg gtctcggacg
    14101 cctggtgcac gacgatgaag agccgttcgc tgtcactgag gtcctgctgg tcgaccggtg
    14161 tcaacgggcg ctggaggtcc agcagttcgg ggaggtgcag atacgtcgca tagttcgggg
    14221 aggtcatcgg acgggctcct cgtgttcggt ccgcgctata ccaggcgccc cgggacggtg
    14281 aggtcggcca gcgcgtcccg gtggacaccg ggcagcaggc tctccagggc ggccgcggcc
    14341 atgtccacgt agcggtgcga cacctcgcgc gccgcggcga cgccgtcgtg gtcgtgcacc
    14401 agccgcgcca tggccgcgta gcgctcctcg accggtacgg ccgtgtcggc gagcagtcgc
    14461 tcgatgtgct gctgctccgc cacgggggca cgctcgtggg cgagcagcac gggcagggtg
    14521 gggcggccgt tgcggacgtc ggagacgttg ggcttgcccg cccgggtgcc gtcgtaggcc
    14581 atgaggtcgt cgcggatctg gtaggcgatg cccagccggt cgctgtactg gctgagcgcc
    14641 cgcaggtcct tgtcgttgcc gccgccgagt gtggcgccga cgccgcaggc catccacagc
    14701 agggcgccgc tcttgtccgc gatcatgccg aggtagtcgt cgacggagca gacctcacgg
    14761 ctcatccgga tctcccggat ggcggcgtcc ccgatacgca ggcccgcctt ggagaggacg
    14821 accaaggcct gcgccacccg ttccgcgggc gcgcccgcct cctggcactc ggcgagggcg
    14881 gcgaagccgt ggaagaagag cccgtccccg ccgacgatcg ccgtcggctg cccgtacacg
    14941 gtgtgggcgg cgggcttgct gcgccgttct ccgtcgtcgt cgatgatgtc gtcgtgcatc
    15001 atcgcgccga cctggacaca ctccacggcc acggcggcgg gcaggacggt cggcaggtcg
    15061 ccgcccaccg cgagggcgga gtgggtcacc agccaggggc ccatcatctt cccgaagggc
    15121 accagtccgt agcggacgat ctcgtcgagg ccggagacgt cgttcggcca gcggtcctcg
    15181 acctcggccc ccacaatcgc tgccagttcg cgatcggcga cccgaggcac atcgatttcg
    15241 gtcatgcgct cgacgctagg cacggcgtac gggcctgtcg tcaccgccgg ggcgcgaggg
    15301 cccgagtggg accggtcgtt ggcatcttcg gtcccggcgg gcgggatacg ggcacgctca
    15361 ggtcggggtc cgggcgagcc ggccggtcag gctggccgcg gccagctcga cccgcgagcg
    15421 gcagccggtg cgggcgaaca ggcgggtgag gtagttctcc acggtcttct cgctgagccg
    15481 caggcgcagt gcgatctgcc ggttcgtcag gccctcgccg atcagctcga tgatccgctg
    15541 ctcggtgacg gccagggcgt cgcgccggcc gcgggcgcgc ggtgcgggca ccccgcgctc
    15601 acgtgtcacc tcgcggacgc gttcgaggag tgccgccgcg ccgcaccggg tggccagggc
    15661 gtgggcctcg cgcaaccagg gccgggggtc gggcgcgaac cgggcgacgg ccaggcagga
    15721 ctccatcagt gcgggcaggt cgccccgctc gcggatcagg tcggtggcct cccgggcgca
    15781 ctccgggtcg cggtggacca ggccccgcgc cagcagcagg ctctcctgcg cgtccacgtg
    15841 gtgctcgtgg ggcaacagct cgatctccgc cagcagttcg gcggccccct cgtggtcgtc
    15901 gccgagtacg gcgatccgca gcgcccgcga cagcaggatg gacagaccgg tgcgcagccc
    15961 ggcccggcgc agccgcggtc cggccagcaa cgcgacccgc accgcctggc cgtcgtcgcc
    16021 cttcctcgcc gccaggccga cccgcgccca ggtgcgcagc acggcgagcc ggggcgcccg
    16081 cgtcgccgcg gtcagccacc gggaggcctg cccgaactcg ccgcgggcgg cgcacatgtc
    16141 cacggcgagc agccgcgccg cgtggcgcgc cagcgtgtcc tcggccgggg agagttccag
    16201 ctcccgtacg gcggacatgg cccgcgtcca gtcggcgtcg gcgtagcccc gcacgacccg
    16261 gtggtaggcg ccgagtacac cggtctccgg cacccggtag tcggcgccga tcaccagccg
    16321 ggccacgtcg gccatgtcgg cgaccaggcg gcctggcgca acccggtcca actcgggcga
    16381 gggcgcggcg ccgcccgagc tgcgccagac ccgctcgcat gcggcgacgt caccgcagag
    16441 cgcggcgctg agcagatccg accgcccggc cccgccccgc gccccgtccc cggcggctgt
    16501 cccgtcccgg gctacggctc ggctccgatc tgtcaccggc accgcccccc accgaagcct
    16561 tgccccagcc ggagtctcgg cctcgccgcc gtcacgcccc ggcctctgcc gtgacttctg
    16621 cccacccccg cggctcggcc cggcccgcgt accggcaccg gcaccggcac cgcaccgcac
    16681 cgcaccgcac ccgcacccgc accgggccac cgtgtcgccg tctgtcgccg ggtggcggcg
    16741 tgggtcgggg gcgaggcggc ggtcgaacca ccactccgag aaggcggtgg gcccgcggcc
    16801 cgggaacggc gcgtccagca gttcccgtac ggcgcgttcg gcgggcggta cgccgctgtg
    16861 cagggcgagg aggatggcgg cgaggcggat ctcgtccacg gactcctccg cgcagccgtg
    16921 ctccgcgtac cgggtcagcg gctcgcgcag cagctcgtac cggccggtcc ggacgaccag
    16981 gaggagcagt ctgcacaggg tgcgggcgtg ttcgggcccg gtcggcggca ggcggcgcag
    17041 tgcggccgcg taccacaggg tggcgcgctc cggttcctcc tgctcggcgg ccgcgcccat
    17101 ggtgagcagc tgccggaccg tgtcgtcgtc gagcgtgacg gtcgctccgc cgcgcgcgac
    17161 gtggtcggcg agcaccacgg ggtcgacgcc gccggaccgc cggtggccgg ccagcagtcg
    17221 ctccgccagc gccgcgtgca gcgcggtgcc gcggcgggcg cggaagcggc cggccgcggt
    17281 ggcggccagg gccgggcatc ggcaggcgat ccggccgtcc gggccggccg tcagcacgcc
    17341 cgcctcgatc agcaggtcga gcccccggcc gcagtcgacg gggtcggcct ccaggatgtc
    17401 ggccagcggt ggcagggcgt ccagatcgag gccgtccagg agcgcgaccg cgcccagcag
    17461 ccggaccgcg gtgccgccca gtgcggacgc gcggcgcaga agcgggtggt cggccgggag
    17521 cgccaccggc tcggccggat cgctcaggca cagccggccc tcgaaggtga cgaggcggcc
    17581 gctgcggcgc agtgcgtcga gcgtgccgag gacggtgccc gggttgccga ggaggggccc
    17641 cagcgccgtg cgcagagcgg tcaccaccga ctcgtcgagg cgtgctcccg ccgcgcggcg
    17701 gaccagggac agcgcgacgt cgtcggcgag cggaccgatc gtcatcaccc ggtcggcgtc
    17761 ggtcagcagt tcggcgagtc ccgggccgcg ctcggcgccc tcctcgcagg tcgccaccac
    17821 caggcagccg gcccggcggg ccgcgctcag caccggcgcg ggctcggcca ccgcgtgcgc
    17881 gtcgtcgacg aggagtgcga cgcgttcccg ccggccgacg gtctcgaaca gaccgtccag
    17941 cgcggcgacc accgccggcg tccagccgcc tctctcccgc cctcgtgcgt cgcgcagttg
    18001 ggccaccgcg ctgagcgcct cgctcagccc gctctcctgc aactgctcga accgctcacg
    18061 cacggcgcgt accagcgcgg cgagggcgta ggggtcaccg ccgccgtccg gtccggtgcc
    18121 gagccgcagc ggcaggaccc gcgccccgtc cgcggccagc agccgcgcga cgctgtccag
    18181 cagcgcggtc cggccgattc cggccgggcc cgtgaggacg atcaggcgtc cgccgtcggg
    18241 agccagcgcg gtgcgcagcg ccgtcagttc ctggtccctg ccccgcaccg cggcgcgcgt
    18301 tcgggccact gccggtcctc cttctgcgac gcctcgcacg gccaaggccc accggaccgc
    18361 cgtgacctgc cgaacgccca acttcgtgct gtagaagccc tgttcgtgcc cggccgacgc
    18421 tgctcgctga tcatatactt ttgaacggtc cgttggctga cgctgcgggc atactgggac
    18481 cgtgatcgac cactggcgtg atgcgcccga cgcggcccgg tcggctccgg caccgttcgg
    18541 ccgtgacgcc gtcgtggcgc acgtcgccga gctggccgtc tcgtcggacg cggcgccgct
    18601 cgtcctggtc accggcccca tcggcatggg acgcagctcg ctgctggccg cggtccgggc
    18661 cgagttgacc gcgagggggt tcactcccct gtcgctgcgg gtggcacgca acgaacgcga
    18721 ccgtccctac tccctcgcct cccgcctctg cgccgagatc gccgcgctcc ggagcggtga
    18781 cgccaggcgt acggcgcggg ccacggccgt ggtgtccctc ggcgaggcgg gccggcagct
    18841 cgccgccgag ctgcggtcgg ccctcaccgt gaacgacaag ctgacggtgc tgatcgacga
    18901 cgcgcactgg gccgaccccg cgtcgcgcgc cgtgctgctg tcgctcaccc gcgcgctggc
    18961 gggcggcccg gtcaccgtcg tctgcacggt gcgcccctca ccggccgatc cggcgagcga
    19021 gcgggccgtg ctggagcagc tgcgggccgc ctcgctcgcc gaggtggtgc cgcttcgccc
    19081 gctgggcgag caggaggtgg ctgcgctgat cgcccacacc ctgcaggcca ggccgacggc
    19141 cgcgctgctg tccagtctgc agcgggagtg ccggggcagg cccgccgccg tgctcgcggc
    19201 cgtggcgggg cacctgcgca ccggcggact tcaggtgtac gaccggcacg tgtacctcac
    19261 gtcgccggac cggccgcccg aactgcccct cgacctgccg ccgatcgagt atctgcgccg
    19321 gctgggcgga acggtctggg cggtggccaa ggcggcggcg gtcatgctcc cgctgggcac
    19381 cgcggccacc gggctgatcg cccgggcggt gggccgggac gaggaggagg tccggggcgc
    19441 gctgtcggag ctgtccgtgg agggcgtgct gcggcaggag accgaggacg ggcggtggcg
    19501 cttccggctg ccgctgctcg cctccgccct gaccggctgc ctcggcccct gggagcggcg
    19561 cagcctggcc cggctggcgg tcaccgcgat ctgggcgggc gacgccgtgg cggacgaccg
    19621 ctacctggcc gatcaactgg tcgtcgcggg gcgctccgtg gacgcccggc gggccgccgg
    19681 tgaactgctc gcccggggca ccgcggcgat gctggacgac gggtactgtg cggaacgctg
    19741 gctgcgcgcc gccgccgagc tggccacgga gccgcggcag cgcgcccggg tgctggtcgc
    19801 ccacgccacc acctgctgcc tgcaactgcg cttcgccgag gcgatcgaca gcgcggggaa
    19861 ggtcttgtcc gagtacgcgg aggaccacgt cgactccgcg acgctgctgg agatccagct
    19921 ggcgtacgtc gtcgcactgg ccggaaccct ggacaccgcc gcgctcaccg agctgtgcga
    19981 cggtggctgg cgctcgctgc cgggcaggca gtggcatcgc gtggtgaccc ggtgcatcgc
    20041 cctgtgccac ctggaccggt ggcgggaggc ggacgagcac ctggcactcc tgcggcacgt
    20101 ctggcatcgg gacgacgacg tcttcgccgg gctcgggctg ctcgtcagcg agtgcaccgg
    20161 agcgtacatg ggccgcttcg aaccgttcga gcaggccgtc gccgacccga ccgactggcc
    20221 cctgtgggcc tcggggcccc gcttccgctt cgagcggctg tggcagctgg cccgggtgct
    20281 gatggccttc ggcgaacagg agcgcgcgga ccggctgctg gcggcccacg acccgccctc
    20341 cgcctaccgg acgctgcccg accaggtggt ggccgacagc cagagcgggc actgggaccg
    20401 cgccctcgac acggcccggc tcggcctggc caccggtctg tccgtcggct acgcgcccag
    20461 ccacaccctg gtgtcccggg agacgagcgt gatactcggt gcgcgcgggc ggctcaccga
    20521 ggcccgcgcg gtgatcgagc gggcgcgttc cgtgcagccg gtgatgctgc acctgctggc
    20581 cgtggcggaa tcgtgcctgg acgaggccct gggggacgtc gaaggcgccc tcgacgtcgt
    20641 cgcccggggg ctggccctgg ccgccgaccg gggtctggtg gtcggcacgg acgtcctgtg
    20701 gctgaggtcg gcggggctgg aactggcccg cggcgaccgc gccgcggcac ggcgggccgt
    20761 ggcggagacc ggccggacgg ccgagctgac cggcaccggc cgggcccgcc tgtgccatct
    20821 gctcgccacc gcgaccgtgg agggcgaccg ggccgccgcg gcggaggcga tcggactcgc
    20881 ccggcagcgc gcgcagccgc tggagctggc cgacacgctg accctggcgg tccgccacga
    20941 ggtggccgac tccgggctgc tgcacgaggc gtacgcgctc tacggcggcc tggacgcgct
    21001 gctgcgcagg gcgcagctgc gcaacctgat gcgcgcacgg ggcgtcaccg tgccgcacag
    21061 ggcggtcgtc accgcggaga acgagcggct ccttgccacc ttggtgaccg aggggctgac
    21121 caaccgcgaa ctcgccgccg cgctgggcag cagcgagaag agcgtggaga gccggctggg
    21181 caggctcttc aaacgtaccg gctaccgttc ccgggtcgag ctggcctccg cgatgctgac
    21241 ggacgactac cgggcctga
//
