Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000665.1:
Cluster 1Terpene / Alkaloid121259

BGC0000665, xiamycin biosynthetic gene cluster from Streptomyces sp. HKI0576. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: xiamycin A
PubChem ID: 38358410
ChemSpider ID: 26364073
SMILES string: Copy to clipboard
Molecular formula: C23H25NO3
Average molecular mass: 363.457 Da
Molecular activity: Other

Class-specific details

Biosynthetic class(es):
Terpene / Alkaloid
Terpene subclass:
Other
Terpene subclass by size:
Sesquiterpene
Final isoprenoid precursor:
FPP
Terpene synthase/cyclase-encoding genes:
CCH63731.1
Prenyltransferase-encoding genes:
CCH63739.1
Alkaloid subclass:
Indole/benzopyrrole

Gene cluster description

xiamycin (BGC0000665). Gene Cluster 1. Biosynthetic class = Terpene/Alkaloid. GenBank HE815466. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Yuta Tsunematsu (University of Shizuoka)

Literature references

1. Li H et al. (2012) Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis. J Am Chem Soc 134(21):8996-9005. doi: 10.1021/ja303004g. Epub 2012
2. Xu Z et al. (2012) Bacterial synthesis of diverse indole terpene alkaloids by an unparalleled cyclization sequence. Angew Chem Int Ed Engl 51(41):10293-7. doi: 10.1002/anie.201204087.
3. Zhang Q et al. (2012) Carboxyl formation from methyl via triple hydroxylations by XiaM in xiamycin A biosynthesis. Org Lett 14(24):6142-5. doi: 10.1021/ol302782u. Epub 2012 Dec 3.