BGC0000665: xiamycin biosynthetic gene cluster from Streptomyces sp. HKI0576
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Location: 1 - 21,259 nt. (total: 21,259 nt).
This entry is originally from NCBI GenBank HE815466.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000665
Short description xiamycin biosynthetic gene cluster from Streptomyces sp. HKI0576
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Sesquiterpene)
  • other (other)
Loci
HE815466.1
via Knock-out studies, Enzymatic assays, Heterologous expression
Compounds
  • xiamycin
  • indosespene
  • sespenine
  • dixiamycin A
  • dixiamycin B
  • sulfadixiamycin A
  • sulfadixiamycin B
  • sulfadixiamycin C
Species Streptomyces sp. HKI0576 [taxonomy]
References
Chemical products information
xiamycin Evidence: NMR [4]
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C23H25N1O3
Chemical database entries
NPAtlas
indosespene Evidence: NMR [5]
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C23H29N1O3
Chemical database entries
PubCHEM
sespenine Evidence: NMR [5]
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C23H29N1O4
Chemical database entries
PubCHEM
dixiamycin A Evidence: NMR [1], NMR [3]
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C46H48N2O6
dixiamycin B Evidence: NMR [1], NMR [3]
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C46H48N2O6
sulfadixiamycin A Evidence: NMR [2]
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C46H48N2O8S1
Chemical database entries
PubCHEM
sulfadixiamycin B Evidence: NMR [2]
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C46H48N2O8S1
Chemical database entries
PubCHEM
sulfadixiamycin C Evidence: NMR [2]
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C46H48N2O8S1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CCH63727.1
  • xiaA
 1 - 1002 (+) XiaA protein
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    • CCH63728.1
    • xiaB
    		 1015 - 2832 (+) XiaB protein
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      • CCH63729.1
      • xiaC
      		 2829 - 3980 (+) XiaC protein
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        • CCH63730.1
        • xiaD
        		 4412 - 5134 (+) XiaD protein
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          • CCH63731.1
          • xiaE
          		 5127 - 5879 (-) XiaE protein
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            • CCH63732.1
            • xiaF
            		 5946 - 7145 (-) XiaF protein
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              • CCH63733.1
              • xiaG
              		 7142 - 7531 (-) XiaG protein
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                • CCH63734.1
                • xiaH
                		 7534 - 9327 (-) XiaH protein
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                  • CCH63735.1
                  • xiaI
                  		 9324 - 9557 (-) Indole oxygenase
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                    • CCH63736.1
                    • xiaJ
                    		 9583 - 10752 (-) XiaJ protein
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                      • CCH63737.1
                      • xiaK
                      		 10906 - 12036 (-) XiaK protein
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                        • CCH63738.1
                        • xiaL
                        		 12059 - 14227 (-) XiaL protein
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                          • CCH63739.1
                          • xiaM
                          		 14256 - 15263 (-) Cytochrome P450
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                            • CCH63740.1
                            • xiaN
                            		 15358 - 18309 (-) XiaN protein
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                              • CCH63741.1
                              • xiaO
                              		 18482 - 21259 (+) XiaO protein
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                                Biosynthesis information
                                Annotation changelog

                                Entry version: next

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2024-06-14
                                MIBiG v4 annotathon
                                • (ID: KTTDKEJDYAQ7MKSNPMBDOYYX)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 4

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-10-07
                                Update chemical activity to schema version 2.11
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Corrected gene identifiers
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated bioactivity data
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: ZUAEFEJPIFGA5SNZGJWBG3IU)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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