BGC0000666: xiamycin A biosynthetic gene cluster from Streptomyces sp. SCSIO 02999
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 29,371 nt. (total: 29,371 nt).
This entry is originally from NCBI GenBank JQ812811.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000666
Short description xiamycin A biosynthetic gene cluster from Streptomyces sp. SCSIO 02999
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Sesquiterpene)
Loci
JQ812811.1
via Knock-out studies, Enzymatic assays
Compounds
  • xiamycin A
Species Streptomyces sp. SCSIO 02999 [taxonomy]
References
Chemical products information
xiamycin A Evidence:
Copy SMILES
C23H25N1O3
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFK78065.1
 1 - 1644 (+) putative Ox3
    copy AA seq
    copy Nt seq
    • AFK78066.1
    		 1641 - 2696 (+) putative alcohol dehydrogenase zinc-binding domain protein
      copy AA seq
      copy Nt seq
      • AFK78067.1
      		 2693 - 3784 (+) XiaA
        copy AA seq
        copy Nt seq
        • AFK78068.1
        		 3843 - 4337 (-) XiaB
          copy AA seq
          copy Nt seq
          • AFK78069.1
          		 4502 - 5278 (-) XiaC
            copy AA seq
            copy Nt seq
            • AFK78070.1
            		 5512 - 6504 (+) XiaD
              copy AA seq
              copy Nt seq
              • AFK78071.1
              		 6517 - 8334 (+) XiaE
                copy AA seq
                copy Nt seq
                • AFK78072.1
                		 8331 - 9482 (+) XiaF
                  copy AA seq
                  copy Nt seq
                  • AFK78073.1
                  		 9930 - 10652 (+) XiaG
                    copy AA seq
                    copy Nt seq
                    • AFK78074.1
                    		 10645 - 11445 (-) terpene cyclase
                    • Scaffold biosynthesis
                    • Knock-out Activity assay
                    copy AA seq
                    copy Nt seq
                    • AFK78075.1
                    		 11512 - 12705 (-) oxidative terpene cyclase
                    • Scaffold biosynthesis
                    • Knock-out Activity assay
                    copy AA seq
                    copy Nt seq
                    • AFK78076.1
                    		 12708 - 13097 (-) XiaJ
                      copy AA seq
                      copy Nt seq
                      • AFK78077.1
                      		 13100 - 14890 (-) C,N- and N,N dimerization
                      • Tailoring
                      • Knock-out Activity assay
                      copy AA seq
                      copy Nt seq
                      • AFK78078.1
                      		 14890 - 15123 (-) XiaL
                        copy AA seq
                        copy Nt seq
                        • AFK78079.1
                        		 15149 - 16318 (-) carboxylase
                        • Tailoring
                        • Knock-out Activity assay
                        copy AA seq
                        copy Nt seq
                        • AFK78080.1
                        		 16457 - 17482 (-) XiaN
                          copy AA seq
                          copy Nt seq
                          • AFK78081.1
                          		 17610 - 19766 (-) epoxidase
                          • Precursor biosynthesis
                          • Knock-out Activity assay
                          copy AA seq
                          copy Nt seq
                          • AFK78082.1
                          		 19795 - 20802 (-) XiaP
                            copy AA seq
                            copy Nt seq
                            • AFK78083.1
                            		 20897 - 23875 (-) XiaQ
                              copy AA seq
                              copy Nt seq
                              • AFK78084.1
                              		 24018 - 26792 (+) XiaR
                                copy AA seq
                                copy Nt seq
                                • AFK78085.1
                                		 27049 - 27486 (+) putative bacillolysin
                                  copy AA seq
                                  copy Nt seq
                                  • AFK78086.1
                                  		 27845 - 29371 (+) putative sodium-coupled permease
                                    copy AA seq
                                    copy Nt seq
                                    Biosynthesis information
                                    Annotation changelog

                                    Entry version: 4

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-10-07
                                    Update chemical activity to schema version 2.11
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 3

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2022-09-15
                                    Updated bioactivity data
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 2

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2019-10-16
                                    Migrated from v1.4
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                    Entry version: 1

                                    Date
                                    Changes
                                    Submitters
                                    Reviewers
                                    2015-06-12
                                    Submitted
                                    • (ID: YU43TGF6RSKW2WJOQIFYBQO4)
                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                    Similar known gene clusters from MIBiG 4.0
                                    Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                    Click on reference genes to show details of similarities to genes within the current region.
                                    Click on an accession to open that entry in the MiBIG database.