BGC0000668: 12-epi-hapalindole C isonitrile biosynthetic gene cluster from Hapalosiphon welwitschii UTEX B 1830
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Location: 1 - 36,570 nt. (total: 36,570 nt).
This entry is originally from NCBI GenBank KF811479.1.

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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000668
Short description 12-epi-hapalindole C isonitrile biosynthetic gene cluster from Hapalosiphon welwitschii UTEX B 1830
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Monoterpene)
  • other (other)
Loci
KF811479.1
via Enzymatic assays, Heterologous expression
Compounds
  • 12-epi-hapalindole C isonitrile
  • 12-epi-hapalindole E
  • 12-epi-fischerindole U isonitrile
  • fischerindole L
  • 12-epi-fischerindole I isonitrile
  • welwitindolinone A isonitrile
  • welwitindolinone B isothiocyanate
  • welwitindolinone C isothiocyanate
  • N-methylwelwitindolinone C isothiocyanate
  • N-methylwelwitinsolinone C isonitrile
  • 3-epi-welwitindolinone B isothiocyanate
  • 3-(Z-2'-isocyanoethenyl)-indole
Species Hapalosiphon welwitschii UTEX B 1830 [taxonomy]
References
Chemical products information
12-epi-hapalindole C isonitrile Evidence: NMR [4]
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C21H24N2
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1547
12-epi-hapalindole E Evidence: NMR [4]
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C21H23Cl1N2
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1553
12-epi-fischerindole U isonitrile Evidence: NMR [4]
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C21H24N2
Chemical database entries
CyanoMetDB CyanoMetDB_1549
NPAtlas
fischerindole L Evidence: NMR [2]
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C21H23Cl1N2
Chemical database entries
CyanoMetDB CyanoMetDB_1557
NPAtlas
12-epi-fischerindole I isonitrile Evidence: NMR [3]
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C21H21Cl1N2
Chemical database entries
CyanoMetDB CyanoMetDB_1565
NPAtlas
welwitindolinone A isonitrile Evidence: NMR [4]
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C21H21Cl1N2O1
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1563
ChemSpider
welwitindolinone B isothiocyanate Evidence: NMR [4]
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C21H21Cl1N2O2S1
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_2307
welwitindolinone C isothiocyanate Evidence: NMR [4]
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C21H19Cl1N2O2S1
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1568
N-methylwelwitindolinone C isothiocyanate Evidence: NMR [4]
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C22H21Cl1N2O2S1
Chemical database entries
CyanoMetDB CyanoMetDB_1516
NPAtlas
N-methylwelwitinsolinone C isonitrile Evidence: NMR [4]
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C22H21Cl1N2O2
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1517
3-epi-welwitindolinone B isothiocyanate Evidence: NMR [4]
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C22H23Cl1N2O2S1
Chemical database entries
NPAtlas
CyanoMetDB CyanoMetDB_1513
3-(Z-2'-isocyanoethenyl)-indole Evidence: Mass spectrometry [1]
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C11H8N2
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHI58816.1
 126 - 998 (-) halogenase, 2OG-Fe(II) oxygenase family
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    • AHI58817.1
    		 1779 - 2822 (-) N-methyl transferase
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      • AHI58818.1
      		 2892 - 3572 (-) Unknown
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        • AHI58819.1
        		 3593 - 4672 (-) Rieske oxygenase
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          • AHI58820.1
          		 4840 - 5928 (-) Rieske oxygenase
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            • AHI58821.1
            		 6124 - 7197 (-) Rieske oxygenase
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              • AHI58822.1
              		 7404 - 8486 (-) Rieske oxygenase
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                • AHI58823.1
                		 8668 - 9354 (-) Unknown
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                  • AHI58824.1
                  		 9427 - 10686 (-) WelD4
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                    • AHI58825.1
                    		 10723 - 11727 (-) WelP2
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                      • AHI58826.1
                      		 13352 - 14056 (+) WelR1
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                        • AHI58827.1
                        		 14278 - 15009 (-) WelR2
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                          • AHI58828.1
                          		 15577 - 16668 (+) WelR3
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                            • AHI58829.1
                            		 16776 - 17420 (-) WelC3
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                              • AHI58830.1
                              		 17445 - 18542 (-) WelT5
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                                • AHI58831.1
                                		 18567 - 19814 (-) WelT4
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                                  • AHI58832.1
                                  		 19954 - 20778 (-) WelT3
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                                    • AHI58833.1
                                    		 20861 - 21724 (-) WelT2
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                                      • AHI58834.1
                                      		 21867 - 24071 (-) WelT1
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                                        • AHI58835.1
                                        		 24125 - 25030 (-) WelC2
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                                          • AHI58836.1
                                          		 25171 - 26397 (-) WelD3
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                                            • AHI58837.1
                                            		 26470 - 28413 (-) WelD2
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                                              • AHI58838.1
                                              		 28667 - 29593 (-) WelP1
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                                                • AHI58839.1
                                                		 29910 - 30731 (-) WelI3
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                                                  • AHI58840.1
                                                  		 30728 - 31723 (-) WelI2
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                                                    • AHI58841.1
                                                    		 32131 - 33102 (-) WelI1
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                                                      • AHI58842.1
                                                      		 33386 - 33895 (+) WelS1
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                                                        • AHI58843.1
                                                        		 33931 - 34446 (+) WelS2
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                                                          • AHI58844.1
                                                          		 34708 - 35877 (-) WelD1
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                                                            • AHI58845.1
                                                            		 35993 - >36568 (-) WelC1
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                                                              Biosynthesis information
                                                              Annotation changelog

                                                              Entry version: next

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2024-05-23
                                                              MIBiG v4 annotathon
                                                              • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 4

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-10-07
                                                              Update chemical activity to schema version 2.11
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 3

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2022-09-15
                                                              Fixed incorrect prenyltransferase identifiers
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2022-09-15
                                                              Updated bioactivity data
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 2

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2019-10-16
                                                              Migrated from v1.4
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              2019-10-16
                                                              Updated compound(s) information (NPAtlas curation)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                              Entry version: 1

                                                              Date
                                                              Changes
                                                              Submitters
                                                              Reviewers
                                                              2015-06-12
                                                              Submitted
                                                              • (ID: XU7PTWDFW5UJ7GLIWVSFLQRF)
                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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