Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000668.1:
Cluster 1Terpene / Alkaloid136570

BGC0000668, welwitindolinone biosynthetic gene cluster from Hapalosiphon welwitschii. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 12-epi-hapalindole C
SMILES string: Copy to clipboard
Molecular formula: C21H24N2
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Terpene / Alkaloid
Terpene subclass:
Other
Terpene subclass by size:
Monoterpene
Final isoprenoid precursor:
GPP
Terpene synthase/cyclase-encoding genes:
Prenyltransferase-encoding genes:
AHI58838, AHI58825
Alkaloid subclass:
Other

Gene cluster description

welwitindolinone (BGC0000668). Gene Cluster 1. Biosynthetic class = Terpene/Alkaloid. GenBank KF811479. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Xinyu Liu (University of Pittsburgh)

Literature references

1. Hillwig ML et al. (2014) Identification and characterization of a welwitindolinone alkaloid biosynthetic gene cluster in the stigonematalean Cyanobacterium Hapalosiphon welwitschii. Chembiochem 15(5):665-9. doi: 10.1002/cbic.201300794.
2. Hillwig ML, Liu X. (2014) A new family of iron-dependent halogenases acts on freestanding substrates. Nat Chem Biol 10(11):921-3. doi: 10.1038/nchembio.1625. Epub 2014 Sep