Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000676.1:
Cluster 1Terpene115629

BGC0000676, aphidicolin biosynthetic gene cluster from Phoma betae. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: aphidicolin
PubChem ID: 457964
ChEBI ID: 2766
ChEMBL ID: 29711
ChemSpider ID: 10280269
SMILES string: Copy to clipboard
Molecular formula: C20H34O4
Average molecular mass: 338.488 Da
Molecular activity: Inhibitor
Molecular target: DNA polymerase alpha

Class-specific details

Biosynthetic class(es):
Terpene subclass:
Terpene subclass by size:
Final isoprenoid precursor:
Terpene synthase/cyclase-encoding genes:

Gene cluster description

aphidicolin (BGC0000676). Gene Cluster 1. Biosynthetic class = Terpene. GenBank AB114137. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression, Sequence-based prediction
Contact for this cluster:Hideaki Oikawa (Hokkaido University)

Literature references

1. Toyomasu T et al. (2004) Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase alpha. Biosci Biotechnol Biochem 68(1):146-52. doi: 10.1271/bbb.68.146.