LOCUS       BGC0000678             13437 bp    DNA     linear   BCT 04-FEB-2015
DEFINITION  Streptomyces avermitilis MA-4680 = NBRC 14893 DNA, complete genome.
ACCESSION   BGC0000678
VERSION     BGC0000678
KEYWORDS    .
SOURCE      Streptomyces avermitilis MA-4680 = NBRC 14893
  ORGANISM  Streptomyces avermitilis MA-4680 = NBRC 14893
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     [WARNING] On Mar 24, 2016 this sequence was replaced by BA000030.4.
            On Jun 15, 2007 this sequence version replaced BA000030.2.
            This work was done in collaboration with Haruo Ikeda(*1), Jun
            Ishikawa(*2), Akiharu Hanamoto(*3), Chigusa Takahashi(*3), Mayumi
            Shinose(*3), Hiroshi Horikawa(*4), Hidekazu Nakazawa(*4), Tomomi
            Osonoe(*4), Norihiro Kushida(*4), Hisashi Kikuchi(*4), Tadayoshi
            Shiba(*5), Yoshiyuki Sakaki(*6,*7), Masahira Hattori(*1,*7)
            and Satoshi Omura(*1,*3).
            Final finishing process and all annotation were done by H. Ikeda
            and J. Ishikawa.
            *1 Kitasato Institute for Life Sciences, Kitasato University *2
            National Institute of Infectious Diseases
            *3 The Kitasato Institute
            *4 National Institute of Technology and Evaluation *5 School of
            Science, Kitasato University
            *6 Institute of Medical Science, University of Tokyo *7 RIKEN,
            Genomic Sciences Center
            All the annotated genes identified are available from following
            urls.
            http://avermitilis.ls.kitasato-u.ac.jp.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:02:29
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1005
                     /codon_start=1
                     /gene="gap1"
                     /locus_tag="SAV_2990"
                     /note="glyceraldehyde-3-phosphate dehydrogenase
                     (insensitive to pentalenolactone); ptlK, pentalenolactone
                     resistance gene, PF02800: Glyceraldehyde 3-phosphate
                     dehydrogenase, C-terminal domain"
                     /product="glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="BAC70701.1"
                     /transl_table=11
                     /translation="MTVRVGINGFGRIGRNVFRAAATRGADLEIVAVNDLGDVATMAHL
                     LAYDSILGRFPEEVTAEPGAIRAGDTTVKVLAERDPAALPWGDLGVDVVIESTGIFTDA
                     AKARAHVDGGAKKVIIAAPASNEDVTVVLGVNQDAYDPERHTIISNASCTTNCLGVLAK
                     VLHDAVGIESGMMTTVHAYTQDQNLQDAPHKDLRRARAAGLNIVPTSSGAAKAIGLVLP
                     ELQGRLDAFALRVPVPTGSVTDLTVTASRSTTVEEVKEAYAKAAAGAYKGLLSYTEAPI
                     VSTDIAGDPASCVFDAELTRVLGSQVKVVGWYDNEWGYSNRLIDLALLVGDTL"
     protocluster    1..13437
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[9228:10239]"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9229..10239
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     cand_cluster    1..13437
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Terpene_synth or Terpene_synth_C or
                     phytoene_synt or Lycopene_cycl or terpene_cyclase or NapT7
                     or fung_ggpps or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..13437
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000678"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..13437
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(Terpene_synth or Terpene_synth_C or phytoene_synt
                     or Lycopene_cycl or terpene_cyclase or NapT7 or fung_ggpps
                     or fung_ggpps2 or trichodiene_synth or TRI5)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            1..1005
                     /gene="gap1"
                     /locus_tag="SAV_2990"
     gene            1366..2223
                     /gene="ptlH"
                     /locus_tag="SAV_2991"
     CDS             1366..2223
                     /codon_start=1
                     /gene="ptlH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2991"
                     /note="pentalenolactone gene cluster, PF05721:
                     Phytanoyl-CoA dioxygenase (PhyH)"
                     /product="1-deoxypentalenic acid 11-beta hydroxylase;
                     Fe(II)/alpha-ketoglutarate dependent hydroxylase"
                     /protein_id="BAC70702.2"
                     /sec_met_domain="PhyH (E-value: 1.8e-22, bitscore: 70.4,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNVTGDYTDCTPLLGDRAALDSFYEEHGYLFLRNVLDRDLVKTV
                     AEQMREGLVALGAADPHATLEELTIDSFESVDEVAMHDYVKYDAFWNNPSTIKVFEQVF
                     GEPVFVFLSTTIRYYPSQAGSEEPSFHYLTPFHQDGFYIGPNQDFRTFWIPLIRTTRES
                     GGVALADGSHRRGKRDHVLNESFRRFGHPVRGIPPTEVSEDEHLLHSPMEPGDILLFHA
                     HMCHKSIPNLSKDPRLMRMSMDTRVQPAKSHRGFNAMTPWTESAKDASKGIMAKITGTP
                     TDVE"
     misc_feature    1456..1458
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2281..3735
                     /gene="ptlG"
                     /locus_tag="SAV_2992"
     CDS             2281..3735
                     /codon_start=1
                     /gene="ptlG"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 312.8; E-value:
                     5e-95)"
                     /gene_kind="transport"
                     /locus_tag="SAV_2992"
                     /note="pentalenolactone gene cluster, PF07690: Major
                     Facilitator Superfamily"
                     /product="putative transmembrane efflux protein"
                     /protein_id="BAC70703.1"
                     /transl_table=11
                     /translation="MDLTSETSPAGGPVEKEDLVRQGSDKPAGLSGAGLAVILTGFALS
                     IADFFIVNVALATVKHDLHASDAELELVVSGYGITYALGLVMGGRLGDAFGRRRLFRDG
                     LIAFTITSALCGFAPNVTFLIAARLLQGAAAAMLVPQVLGTIQAATDGASRARAISLYG
                     ATAGIAAVAGQIIGGFLLMLDIGDSGWRSVFMINVPIGLVALLLVRRMPATKADRKPGL
                     DLLGTALFGVTMVCVLMVIVEGRSLGWPVWLWSLLVVAAVAAVTLVRVERGLEARGGSP
                     LLPPSILARHSMRTGLMAVVPFSIGFGSFLFVYTLVAQDKLGLGALASAGVLSPFASSF
                     FVVSLFTPKITARIGRRIVSVGAVVQGTGLLLLALLIGVEWPHLPLLLVLAVLAFTGIG
                     QALIGPTLLRMVLADVPPASAGTGSGVLVTSQQTATALGVTVGGTLYLTLASSLGDASG
                     AVLVLVLLALFSAVIFALSLRLPEPR"
     misc_feature    2368..2370
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3811..4623
                     /gene="ptlF"
                     /locus_tag="SAV_2993"
     CDS             3811..4623
                     /NRPS_PKS="Domain: PKS_KR (6-173). E-value: 4.9e-13. Score:
                     41.2. Matches aSDomain: nrpspksdomains_SAV_2993_PKS_KR.1"
                     /codon_start=1
                     /gene="ptlF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     184; E-value: 5.9e-56)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2993"
                     /note="pentalenolactone gene cluster, PF00106: short chain
                     dehydrogenase"
                     /product="1-deoxy-11beta-hydroxypentalenic acid
                     dehydrogenase"
                     /protein_id="BAC70704.1"
                     /sec_met_domain="adh_short (E-value: 9.5e-32, bitscore:
                     100.2, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHLQPSTAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGA
                     VEELAAHGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVP
                     LDEMHAVFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHA
                     DLAAARSLRADLDGTPVRVSVLCPGRVDTPMTRGLVAPRNATGNTTISADEAADAVWNA
                     LGSDRFYIFTNADAQTRLGDQFNDVWRHLAREKYWTESSSPSVNSSRP"
     aSDomain        3829..4329
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAV_2993_PKS_KR.1"
                     /evalue="4.90E-13"
                     /label="SAV_2993_PKS_KR.1"
                     /locus_tag="SAV_2993"
                     /protein_end="173"
                     /protein_start="6"
                     /score="41.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAA
                     HGADVTAVVADLTDPAAVQELADTAFGRLGDIDVVCNNAGVVGPVGMPLWSVPLDEMHA
                     VFDVNYWAHVHVARAFVPRLLDSGRPSHLVQTASMSAFVVGAGTASYAASKHADLAAAR
                     SLRA"
     CDS_motif       3835..3972
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_SAV_2993_0001"
                     /evalue="1.20E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="SAV_2993"
                     /protein_end="54"
                     /protein_start="8"
                     /score="18.0"
                     /tool="antismash"
                     /translation="VVTGAASGIGFALSARLAQAGARVVMTDIAGDGLAGAVEELAAHG
                     A"
     gene            4681..6465
                     /gene="ptlE"
                     /locus_tag="SAV_2994"
     CDS             4681..6465
                     /codon_start=1
                     /gene="ptlE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="other (smcogs) SMCOG1092:hypothetical
                     protein (Score: 411.4; E-value: 9.8e-125)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2994"
                     /note="pentalenolactone gene cluster, PF00743:
                     Flavin-binding monooxygenase-like"
                     /product="putative monooxygenase"
                     /protein_id="BAC70705.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.4e-09, bitscore:
                     27.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDIEAVRAKYREERDKRVQADGGRQYLSAQGEFAHYADDPHAKP
                     IERAPVSDEVDVTIIGAGIGGLLLGARLREACAFDTIRLVDKAGDVGGTWYWNRFPGLR
                     CDVESYVYMPLLEELGRLPSEKYATGAEIFEHCQAIARTYDLYDEALLQTSVTELSWDE
                     DSSRWLVRTDRGDLVRSRFVAMAIGSLHRPKLPSIPGTEAFQGHSFHTSRWDFAYTGGD
                     ISGGLEKLGDKRVGIVGTGATAVQCIPHLAESAAHLYVFQRTPSTVSVRNNRPTDPGWA
                     AGLEPGWQQRRMDNFHALTSGVDQDVDLVQDGWTEITSKLAAILPKSAADADPKDIGTA
                     VELADFHKMEELRKRVDAIVHDKDTADALKPYYRLFCKRPCFHDGYLDTYNRPNVTLVD
                     TQGRGVERLTPTSVVAGGREYPVDCLIFASGYESEFGVPYTNRTGFSIVGRDGIRLSEK
                     WAEGARTFHGLQVNGFPNCFILSKAQSGLHVNVPYMLNEQSKHVAYILKAVQQRGRQVV
                     EASATGEKEWVETILRLANRNLDFTESCTPGLFNNEGNPRNVAILNSSYGGGSVGFVNI
                     LKRWREADDLADLELREG"
     misc_feature    6451..6453
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6466..7386
                     /gene="ptlD"
                     /locus_tag="SAV_2995"
     CDS             6466..7386
                     /NRPS_PKS="Domain: TauD (14-287). E-value: 1.4e-53. Score:
                     174.2. Matches aSDomain: nrpspksdomains_SAV_2995_TauD.1"
                     /codon_start=1
                     /gene="ptlD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121:dioxygenase, TauD/TfdA (Score: 271.2; E-value:
                     1.5e-82)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2995"
                     /note="pentalenolactone gene cluster, PF02668: Taurine
                     catabolism dioxygenase TauD, TfdA family"
                     /product="putative dioxygenase"
                     /protein_id="BAC70706.1"
                     /sec_met_domain="TauD (E-value: 3.3e-54, bitscore: 174.2,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAMDITRIPGSAIGAVVAGADFSGTIDDTQVEEIWQALDQHLV
                     LVFRGHKDPSNDDLLMFARRFGHVPKTGLTTGASPDHNEILLISNILDENGQKIGVGNA
                     EWMDWHTDYSFRPRVSRIGFLAAVELPPSGGGQTLFTDMYTAYESLPDDLRQRLHSYRA
                     RHSLRSGYEDVIEEEYQGEVSIEGPTAKPFVAPEDGTATVHQLIARNPRTGRRAVYANP
                     LNTKRILELDVTSSKEVLQQLFAKPGEPELTYAHEWLPGDIVMWDQLGTVHAKRAFDPT
                     ERRLLRKVVTIFDDPAEPWHPEDAA"
     aSDomain        6508..7326
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAV_2995_TauD.1"
                     /evalue="1.40E-53"
                     /label="SAV_2995_TauD.1"
                     /locus_tag="SAV_2995"
                     /protein_end="287"
                     /protein_start="14"
                     /score="174.2"
                     /tool="antismash"
                     /translation="IGAVVAGADFSGTIDDTQVEEIWQALDQHLVLVFRGHKDPSNDDL
                     LMFARRFGHVPKTGLTTGASPDHNEILLISNILDENGQKIGVGNAEWMDWHTDYSFRPR
                     VSRIGFLAAVELPPSGGGQTLFTDMYTAYESLPDDLRQRLHSYRARHSLRSGYEDVIEE
                     EYQGEVSIEGPTAKPFVAPEDGTATVHQLIARNPRTGRRAVYANPLNTKRILELDVTSS
                     KEVLQQLFAKPGEPELTYAHEWLPGDIVMWDQLGTVHAKRAFDPTERRLLR"
     gene            7438..7614
                     /gene="ptlC"
                     /locus_tag="SAV_2996"
     CDS             7438..7614
                     /codon_start=1
                     /gene="ptlC"
                     /locus_tag="SAV_2996"
                     /note="pentalenolactone gene cluster"
                     /product="hypothetical protein"
                     /protein_id="BAC70707.1"
                     /transl_table=11
                     /translation="MEQTVRSGNGAAGGILGHSSAGLRNDRHDGALTPGAAPQRSSTVD
                     PVHLVDPVKGVAS"
     gene            7611..8624
                     /gene="ptlB"
                     /locus_tag="SAV_2997"
     CDS             7611..8624
                     /codon_start=1
                     /gene="ptlB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182:Polyprenyl synthetase (Score: 277.8; E-value:
                     1.5e-84)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2997"
                     /note="pentalenolactone gene cluster, probably farnesyl
                     pyrophosphate synthase (idsA2)"
                     /product="polyprenyl diphosphate synthase"
                     /protein_id="BAC70708.1"
                     /transl_table=11
                     /translation="MTVTPESLHRSRDAITPALRTALHLLDEETRHQAAYHLGWIEADG
                     TPADGGGGKAVRPALALLSAQAAGAPAETGLPGAVAVELVHNFSLLHDDLMDGDEERRH
                     RRTVWTLWGASGAILTGDALLALAQEVLLDCGLPTGAAAARLLARTTRDLIRGQVQDVA
                     FERRAHVPIEECVDMAAGKTGALLSASAAIGAVLAGAPVTTVDALALYGQQVGLAFQLT
                     DDVLGIWGDPAVTGKSVHSDLRARKKSLPVTYALNQGGTVSVELATWLSAPGEPDEAEL
                     RRAADLVAAAGGRDWATAEAARRMALGEAALRGVDLDAAARDELIALGHFVVDREV"
     gene            9229..10239
                     /gene="ptlA"
                     /locus_tag="SAV_2998"
     CDS             9229..10239
                     /codon_start=1
                     /gene="ptlA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Terpene_synth_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Terpene synthase/cyclase metal-binding domain
                     protein (Score: 272.1; E-value: 1.2e-82)"
                     /gene_kind="biosynthetic"
                     /locus_tag="SAV_2998"
                     /note="pentalenolactone gene cluster, PF03936: Terpene
                     synthase family, metal binding domain"
                     /product="pentalenene synthase"
                     /protein_id="BAC70709.1"
                     /sec_met_domain="Terpene_synth_C (E-value: 1.2e-46,
                     bitscore: 149.1, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFHIPFPSRRSPDFERARADHLSWPRALGLIGTDAAAERH
                     SRGGYADLAARFYPSATGADLDLGVDLMSWFFLFDDLFDGPRGEDPQETRKLTDAVAAA
                     LDGPLPTSAPPIAHGFADVWRRTCQGMSPAWRARSARHWRNYFSGYVDEAVSRHLNTPY
                     DSAGHYLAMRRQTIGVQPTVDLAERSCHCEVPQRVFDSAVLFAMLQIATDTNLILNDIA
                     SLEKEEARGELNNMVFILMREHGWTRGRSIAHMQDGVRTRLEQFLLLEACLPKVYDTFE
                     LTAQERESAEKYRMDGVRSVIRGSYDWHRSSGRYAADYAIAASYQGYLEELGSTL"
     gene            10296..11645
                     /gene="ptlI"
                     /locus_tag="SAV_2999"
     CDS             10296..11645
                     /codon_start=1
                     /gene="ptlI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 418.4; E-value:
                     6.4e-127)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAV_2999"
                     /note="cyp13, CYP183A1, pentalenolactone gene cluster"
                     /product="pentalenene C13 hydroxylase; cytochrome P450"
                     /protein_id="BAC70710.1"
                     /sec_met_domain="p450 (E-value: 2.5e-82, bitscore: 266.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQHTFVAGTAPGAVPVVGHAWQMMRRPLHFMSSLSAHGDLVKIR
                     IGPTSAYVPCHPELLRQVLTNDRVFDKGGVFYDRARDIAGNGLVTCPYRDHRRQRRLMQ
                     SAFQRTQLERYSTAMRAEIDATAARWHDGTVIDAFPELYGMALRTVARTLYSTPVTEEL
                     AQRVEQAFDTVLNGLFRQMFLPHSLRRLPTPANLRYRNNLRFLHDTVQDLITEYRRDDT
                     QRDDLLSALLASRDEDGGRLGDTEIHDQVITVMAAGTETVAGTLTWIFHLLSRHPEIEA
                     RLYEEIDTVLDGKPPHWDDLPSLSLTDRIITEALRMYPPAWIFTRLTASDVDLAGVRLP
                     EGTTIVFSPSSVQRHSEAYDDASRFDPDRWLPDRTSAVARQAFTAFGTGARKCIGDLFA
                     RTEATLALATMLSQWRVTVEPDADVRPVALATVYHPRRLRLRLTARTPGQ"
     gene            11705..12166
                     /gene="ptlR"
                     /locus_tag="SAV_3000"
     CDS             11705..12166
                     /codon_start=1
                     /gene="ptlR"
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 88.6; E-value: 6.9e-27)"
                     /gene_kind="regulatory"
                     /locus_tag="SAV_3000"
                     /note="pentalenolactone gene cluster, PF00165: Bacterial
                     regulatory helix-turn-helix proteins, AraC family"
                     /product="putative AraC-family transcriptional regulator"
                     /protein_id="BAC70711.1"
                     /transl_table=11
                     /translation="MANLEDLVRLRKARDRMDREYAEQLDIAALARTALMSPGHFQRSF
                     RAAFGETPYSYLMTRRIERAKALLRRGDLTVTEVCLAVGCTSLGSFSSRFTELVGETPS
                     AYRARSHEHGAPIPPCVAKGLTRPRRGRPVYGRADTAGGTWTTGPSVTS"
     gene            12163..12597
                     /gene="ptlJ"
                     /locus_tag="SAV_3001"
     CDS             12163..12597
                     /codon_start=1
                     /gene="ptlJ"
                     /locus_tag="SAV_3001"
                     /note="pentalenolactone gene cluster, PF00903:
                     Glyoxalase/Bleomycin resistance protein/Dioxygenase
                     superfamily"
                     /product="putative lyase"
                     /protein_id="BAC70712.1"
                     /transl_table=11
                     /translation="MNMDTDPGVMLSQCFIAVDDHDKALAFYRDVLGLEVRNDVGFEGM
                     RWVTVGSPLQPDVEIVLEPPGANPDASEADRQAMAELLAKGMLRGVIFSTPDCDALFAR
                     VEASGAEVLQEPMDQPYGVRDCAFRDPAGNLLRFKQRSAA"
     gene            12667..13437
                     /gene="ptlL"
                     /locus_tag="SAV_3002"
     CDS             12667..13437
                     /codon_start=1
                     /gene="ptlL"
                     /locus_tag="SAV_3002"
                     /note="pentalenolactone gene cluster"
                     /product="hypothetical protein"
                     /protein_id="BAC70713.1"
                     /transl_table=11
                     /translation="MAPVRPGRERSMSEPIRWAYAFVDRPAAEFVRAVDFWTAVTATER
                     SESRGDQGEFVSLLPGAGDACVKAQGVRDGTGGAHLDLAVANVPALVGAARRLGAEVVA
                     EHPGWAVLRSPGGQLFCAVPWHGESARPPVVEGSRLDQLCIDLAPAVYDLDVAFWSDLT
                     GWTSHPGALPEFHLVRPPEGLPIRILLQRLGTDRPTSAHLDLACADIEATRVRHEELGA
                     TLVARGARWTVLRDPAGGTYCLTARDPETGSLPA"
ORIGIN
        1 atgactgttc gtgtcggcat caatggcttc gggcggatcg gacgcaacgt cttccgcgcg
       61 gcagccaccc ggggcgcgga tctggagatc gtcgccgtca acgatctcgg cgacgtggcg
      121 accatggccc atctgctggc ctacgactcg atcctgggcc gcttcccgga ggaggtcacc
      181 gcggaacccg gtgcgatccg cgccggcgac accaccgtca aggttctcgc cgagcgcgac
      241 cccgccgccc tgccctgggg cgacctgggc gtggacgtgg tcatcgagtc caccggcatc
      301 ttcacggacg cggccaaggc ccgcgcgcac gtggacggcg gcgccaagaa ggtcatcatc
      361 gcggccccgg ccagcaacga ggacgtcacg gtcgtgctcg gcgtgaacca ggacgcctac
      421 gacccggagc gccacacgat catctccaac gcctcgtgca ccaccaactg cctcggcgta
      481 ctggccaagg tgctgcacga cgccgtgggc atcgagtccg gcatgatgac cacggtccac
      541 gcctacaccc aggaccagaa cctccaggac gccccgcaca aggacctgcg ccgtgcccgg
      601 gccgcgggcc tcaacatcgt gcccacctcc agcggagccg ccaaggccat cggcctggtg
      661 ctgcccgaac tccagggccg cctcgacgcc ttcgccctgc gggtccccgt ccccaccggc
      721 tcggtcaccg acctgacggt caccgccagc cgcagcacca cggtggaaga ggtcaaggag
      781 gcgtacgcca aggccgccgc cggcgcgtac aagggtctgt tgtcctacac cgaggccccc
      841 atcgtcagca ccgacatcgc gggggacccc gcctcctgcg tcttcgacgc cgagctgacc
      901 cgcgtactgg gctcccaggt caaggtcgtc ggctggtacg acaacgagtg gggctactcc
      961 aaccgcctca tcgacctggc cctgctggtc ggcgacaccc tctgacggca gcggcaacga
     1021 cggagtccgg cgggcaacga cgccccgccg gactccgcat gtgtgcggcc gcttcccggg
     1081 tgaattcaac catgcatttc aggcctttta tgcagagcgt gtattcacta ctgccgatat
     1141 cagccgccgg ccgtgcacac aaaggagagc cggtcatcac acatgggcgc ggcaacggtt
     1201 ctggttaaat cctggtgaac gaaagtctcc acatgcacga attcaagcca gtcggccgga
     1261 accggcacac tatatccgca aatcgttatg gcattgcgcc cccaatgcgc ggtagtgttt
     1321 gattgcagta ccacggccac tgaggtctca caaggagatg aatctgtgac gaacgtgact
     1381 ggggactaca cggactgcac tcctctgctc ggcgaccgag cggcactcga cagcttctac
     1441 gaggaacacg gctacttatt cctgcggaac gtactcgacc gtgacctcgt caaaacggtg
     1501 gcggagcaga tgcgggaagg actcgtcgcg ctcggtgccg cggatccgca cgccacgctc
     1561 gaggaactca cgatcgactc cttcgagtcg gtcgacgaag tggccatgca cgactacgtc
     1621 aaatacgacg cattctggaa caacccgtcg accatcaagg ttttcgagca ggtgttcggc
     1681 gagccggtat tcgtgttcct ctccacgacc atccggtact acccgtcgca ggcgggctcc
     1741 gaggagccgt ccttccacta cctgacgccg tttcaccagg acggcttcta catagggccc
     1801 aaccaggact ttcgcacctt ctggatcccc ctgatacgga cgaccaggga gtccggaggt
     1861 gtcgcgctgg cggacggcag ccaccggcgc ggaaagcgcg accacgtgct caacgagtcc
     1921 ttccgcaggt tcggccaccc ggtgcgcgga attccgccga cggaggtgag tgaggacgaa
     1981 cacctgctgc actcccccat ggagccggga gacatcctcc tctttcatgc gcacatgtgc
     2041 cacaaatcaa ttccgaacct gtcgaaggac ccgcgcctca tgcggatgtc gatggacacc
     2101 cgggtacagc ccgcgaaatc ccaccgcggc ttcaacgcaa tgacgccctg gacggaatcg
     2161 gcaaaggacg cgtcaaaggg aatcatggcg aagatcaccg gtacccccac cgacgtggaa
     2221 tgacgaccaa cccccacccg gagattttcc ccggcgggcg tcgattcgaa aaacagaggt
     2281 atggatttga cttcagagac gtcgcccgca ggtggcccgg tggaaaagga agatctggtc
     2341 cgccagggca gtgacaaacc agcgggatta tcgggcgccg gcctggcagt gatcctgacg
     2401 ggcttcgcgc tgtccatcgc cgacttcttc atcgtcaacg tggcgctggc cacggtgaaa
     2461 cacgacctcc acgcatccga tgccgagctg gagctggtcg tgtccggcta cggaatcacc
     2521 tatgcgctcg gcctggtcat gggcgggcgt ctgggagacg cgttcggcag acgacgtctc
     2581 ttccgtgacg gcctgatcgc gttcacgatc acgtcggcac tgtgcggctt cgcgccgaac
     2641 gtcaccttcc tcatcgccgc ccgtctgttg cagggcgcgg ccgccgcgat gctcgtaccg
     2701 caggtgctgg gcaccatcca ggcggcgacc gacggcgcgt cccgcgcccg ggcgatcagc
     2761 ctctacggcg ccaccgccgg gatcgcggcg gtggccggac agatcatcgg cggattcctg
     2821 ctgatgctcg acatcggcga ctccggctgg cgatccgtgt tcatgatcaa tgtgccgatc
     2881 ggtctggtgg cgctgctgct ggtccggcgc atgcccgcca ccaaggcgga ccggaaaccg
     2941 ggcctcgacc tgctcggcac ggccctgttc ggggtgacca tggtctgcgt gctgatggtg
     3001 atcgtcgagg gcaggtcgct cggctggccg gtctggctgt ggtcactgct ggtggtcgcc
     3061 gccgtcgcgg ccgtgactct ggtcagggtc gagcgcgggc tggaggcccg gggcggttca
     3121 ccgttgcttc ccccctcgat cctggcccgc cacagcatgc gcacggggct gatggcggtc
     3181 gtgcccttct ccatcgggtt cggcagcttc ctgttcgtct acaccctggt cgcgcaggac
     3241 aagctgggcc tcggggcgct ggcctcggcc ggcgtgctgt ccccgttcgc ctcgtccttc
     3301 ttcgtggtct cgctgttcac cccgaagatc acggcccgta tcggccggcg catcgtgtcg
     3361 gtgggcgcgg tcgtccaggg cacgggcctg ctgctgctcg ccctcctgat cggagtggag
     3421 tggccgcatc tgccgctcct gctggtcctg gcggtgctcg ccttcaccgg catcggccag
     3481 gctctgatcg gaccgacact gctgaggatg gtgctcgccg acgtaccccc cgcgtcggcg
     3541 ggcaccggca gtggagtgct ggtcaccagc cagcagacgg caacggccct gggcgtcacg
     3601 gtcggcggga ccctctacct caccctcgcg agctcgctcg gcgacgcgtc cggggcggtg
     3661 ctcgtcctcg ttctgctggc cctgttctcc gcggtcatct tcgccctgag cctgcggctg
     3721 cccgagccgc gctagccgac agccgctgcc cgagccgcgc cggccgacag acgcggaaga
     3781 accgctcgcc gacacacgtg gagaagctgc atgcaccttc aaccgagtac ggccgtcgtg
     3841 accggcgcgg cgagtggcat cggtttcgcg ctcagcgccc gactggcaca agcgggcgcc
     3901 agggtcgtga tgacggacat cgcgggtgac ggcctggccg gggccgtcga ggagctggcc
     3961 gcgcacggcg cggacgtcac cgccgtggtc gccgacctca ccgacccggc cgcggttcag
     4021 gagctggccg acacggcctt cgggcggctc ggcgacatcg acgtggtctg caacaacgca
     4081 ggcgtcgtcg gaccggtcgg aatgccgctg tggagcgttc ccctggacga gatgcacgct
     4141 gtcttcgacg tcaactactg ggcgcacgtc catgtcgcgc gggccttcgt gccgcgcctc
     4201 ctcgacagcg ggcgcccctc gcacctcgtg cagaccgcct cgatgtccgc gttcgtcgtc
     4261 ggcgcgggta ccgcgtcgta cgccgcgtcc aagcatgcgg acctggccgc ggcccgaagc
     4321 cttcgggcgg acctcgacgg cactcccgtg cgggtctcgg ttctctgccc ggggcgggtc
     4381 gacacaccga tgacccgggg tcttgtcgct ccccggaacg cgaccgggaa cacgacgatc
     4441 agcgcggacg aagcggccga cgcggtgtgg aacgcgctgg gctcggaccg cttctacata
     4501 ttcaccaacg ccgatgccca aaccaggctc ggcgatcaat tcaacgacgt atggcgccat
     4561 ctggcacggg aaaagtactg gaccgaatcc tcttcaccga gcgttaacag ttctcgccca
     4621 tgaccaccgg gtttcgcggg cagaaaccca ccgcaccgat atctttatga gggagatacc
     4681 gtggtggata tcgaggcagt gagagcgaag taccgggagg aacgcgacaa gcgcgtgcag
     4741 gccgatggtg gccgacagta cctgagtgcg cagggggaat tcgcccatta cgccgacgat
     4801 cctcacgcga agccgatcga gcgggctccc gtttccgacg aagtggatgt caccatcatc
     4861 ggcgcgggaa tcggcggact gcttctggga gcccggctgc gcgaggcgtg cgcattcgac
     4921 accatccgac tcgtcgacaa ggccggggac gtcggcggga cctggtactg gaaccgtttt
     4981 cccgggctgc gctgcgatgt cgagagctat gtctacatgc cgcttctcga agagctggga
     5041 cgcctcccct cggagaagta cgcgaccggc gccgagatat tcgagcactg ccaggccatc
     5101 gcgcggacat acgatctcta tgacgaggcg ttgcttcaga cctccgtcac cgagctgagc
     5161 tgggacgagg attcctcgcg atggctggtg cgcacggacc gcggggacct cgtccgatca
     5221 cgcttcgtgg ccatggcgat cgggtccctg cacaggccca agcttccctc gatacccgga
     5281 acagaggcct tccaaggaca ctcgttccac accagccgct gggatttcgc atacaccggc
     5341 ggtgacatct cgggcgggct ggagaaactc ggggacaagc gggtcggaat cgtcggaacc
     5401 ggtgcgacgg cagtccagtg catcccgcat ctggccgagt cggcagcgca tctctacgtc
     5461 ttccagcgga cgccgtcgac cgtcagcgta cgaaacaaca ggccgaccga cccgggctgg
     5521 gcggcggggc tcgaacccgg ctggcagcaa cggcggatgg acaacttcca tgcgctgacc
     5581 tcgggcgtcg accaggacgt ggacctcgtc caggacggct ggacggagat cacctccaag
     5641 ctcgccgcga tcctcccgaa gtcggcggcc gacgcggacc cgaaggacat cggcaccgcc
     5701 gtcgaactcg cggacttcca caagatggag gagctgagga aacgggtcga cgcgatcgtc
     5761 cacgacaagg acaccgccga cgccctgaag ccgtactacc ggctcttctg caaacgaccg
     5821 tgcttccacg acggatatct ggacacttac aaccggccca acgtcaccct ggtggacacc
     5881 cagggacgcg gagtggagcg cctcaccccg acctccgtgg tggccggcgg ccgggaatac
     5941 ccggtcgact gcctcatctt cgcctcgggc tacgaatccg aattcggcgt cccctacacg
     6001 aaccgcaccg gattcagcat agtcggccgg gacggaattc gactgtccga gaagtgggcc
     6061 gagggcgccc gcaccttcca cggtctccag gtgaacggct tccccaactg cttcatcctg
     6121 tccaaggcgc agtcgggtct ccacgtcaat gtgccgtaca tgctcaatga gcagagcaaa
     6181 cacgtcgcct acatcctcaa ggccgtgcag cagcgcggtc ggcaggtggt ggaagcatcc
     6241 gccaccggcg agaaggaatg ggtggagacg atcctcaggc tggcgaaccg gaacctcgac
     6301 ttcaccgagt cctgcacccc gggccttttc aacaacgagg gaaaccctcg aaatgtggcc
     6361 atcctcaact ccagctacgg aggcggatcg gtcggattcg tcaatatttt gaaacggtgg
     6421 cgagaggcgg acgacctcgc cgacctcgaa ttacgtgaag ggtaggtgtc aagagcaatg
     6481 gacattacgc ggatacctgg ttcggcgatc ggcgcggtcg tggccggcgc cgacttttca
     6541 ggcaccatcg acgacacgca ggtcgaagag atctggcagg ccctcgacca gcacctcgtg
     6601 ctggttttcc gcgggcacaa ggatccctcg aacgacgacc tcctcatgtt cgcccggcgc
     6661 ttcgggcacg taccgaagac cggcctgacg accggtgcca gcccggatca caacgagatc
     6721 ctcctcatct ccaacatcct cgacgagaac gggcagaaga taggcgtcgg caacgcggag
     6781 tggatggact ggcacacgga ctactccttc cgcccgaggg tgtcccgcat cggcttcctg
     6841 gcggcggtcg agctaccgcc gtcgggcggc ggccagacgc tgttcaccga catgtacacg
     6901 gcctacgaat ccctcccgga cgacctccgg cagcgcctgc actcctaccg ggccaggcat
     6961 tcgctccggt ccggctacga ggacgtcatc gaggaggagt accagggcga ggtctccatc
     7021 gaagggccga ccgcgaaacc gttcgtggcc cccgaggacg gtacggcgac ggtccatcag
     7081 ctgatcgcca ggaacccgcg gaccggccgc cgcgcggtgt acgccaaccc gctcaacacc
     7141 aaacgcatcc tcgaactgga cgtcacctcc agcaaggagg tgctccagca gctgttcgcc
     7201 aagcccggtg agccggaact gacctacgcc cacgagtggc tccccggtga catcgtcatg
     7261 tgggaccagt tggggaccgt ccacgccaaa cgggctttcg atccgaccga gcgccggctc
     7321 ctgcgcaagg tcgtcacgat cttcgacgac ccggcggagc cgtggcaccc ggaggacgcg
     7381 gcgtgatgcc gcgcgggccg aggcggtgtc actcgcgcgt cagccaggtc ggcaagcatg
     7441 gaacagaccg tccgcagcgg caacggggcc gcaggcggca tcctcggcca ctcctcggcc
     7501 ggactccgga atgacaggca cgacggcgcc ctcacaccag gagcggcgcc gcagcgttcg
     7561 tccaccgtgg accccgtgca cctggtggac cccgtgaagg gtgtggcgtc atgaccgtga
     7621 ccccggaaag tctgcaccgc agccgcgacg cgatcacacc ggcgttgcgc accgcgctcc
     7681 acctgctcga cgaggagacc cgccatcagg cggcgtacca cctcggctgg atcgaggccg
     7741 acggcacccc ggcggacggc ggcggaggca aggccgtacg gcccgcgctc gcgctgctgt
     7801 cggcgcaggc ggccggcgca ccggcggaaa ccggcctgcc cggtgcggtg gccgtcgaac
     7861 tggtgcacaa cttctcgttg ctgcacgacg acctgatgga cggcgacgag gagcgtcggc
     7921 atcgacgtac ggtctggacg ctgtggggcg cctcgggcgc gatcctcacc ggtgacgcgc
     7981 tgctggcgct cgcgcaggag gtgctgctcg actgcgggct gcccacgggg gcggccgcgg
     8041 cgcggctgct cgcccgcacc acccgcgacc tcatccgcgg gcaggtgcag gacgtggcgt
     8101 tcgagcggcg ggcccatgtg ccgatcgagg agtgcgtcga catggcggcc ggcaagaccg
     8161 gcgcgctgct gtcggccagc gccgcgatcg gtgccgtact ggccggcgcg ccggtgacca
     8221 ccgtcgacgc cctggcgctc tacgggcagc aggtgggcct cgccttccag ctgaccgacg
     8281 acgtcctcgg catctggggc gacccggctg tcaccggcaa gtcggtccac tccgacctgc
     8341 gggcccgcaa gaagtcgctg ccggtcacgt acgcgctcaa ccagggcggg accgtgagtg
     8401 tcgagctggc cacctggctc tccgcaccag gcgagcccga cgaggcagag ctgcgccggg
     8461 cggccgacct ggtggcggcg gccggcggcc gcgactgggc caccgccgag gcggcccggc
     8521 gcatggcgct cggggaggcc gcgctgcgcg gcgtcgacct ggacgccgcg gcgcgcgacg
     8581 agctcatcgc cctcggacac ttcgtcgtcg accgggaggt gtgaggtggc gagcgccgcc
     8641 ggccggacac ccgcccggcc cgcggccgac gctccgcggg ccaggccggc cgacgctccg
     8701 cggcccgagt cggccggcgc tgcgcggccc gagtcgggcc acggccccga accctgccga
     8761 gccgtcgccg aagccctgcc cgcagcgtcc ggaaccgccc cacgcacacg cacacgcaca
     8821 cgcacggggg caggcaacgc cgcccgccct cgtacgacca cccccaccgc aggcagcgcc
     8881 gcccgcaccc gtacgacagc caccaccgcc ctccccaccg caggcagcgc cgcctgctcc
     8941 cggcggatgt ccgcgaccgg caggccgtga ccagccggct cggcgcccgc gggtgtcccc
     9001 gctggtgccc cggaaggccc gcccggtcgt gaccgtcgtt cagccctcca ccgctcaggc
     9061 cgccttgcgc cgatcccacc cccggaggcg cccgctccct cctcacgggt tcccgccgcg
     9121 cccggcccgg ccggcccgtc gaaccccccg tgccgaaacg cttcctcacc cgtcgcggac
     9181 cggcatggca cgcctgtgac ccacaacagc ccccccagga gacccgcaat gccccaggac
     9241 gtcgacttcc acataccgtt ccccagccgt cgcagccccg acttcgagcg ggccagggcc
     9301 gaccacctca gctggccccg cgcgctcggc ctcatcggca ccgacgccgc cgccgagcgc
     9361 cacagccggg gcggctacgc cgatctggcc gcccgcttct acccctcggc caccggagcc
     9421 gacctcgacc tgggcgtcga cctgatgtcg tggttcttcc tcttcgacga cctcttcgac
     9481 gggccgcgcg gcgaggaccc ccaggagacc aggaagctca ccgacgccgt cgccgccgcg
     9541 ctcgacggcc ccctgcccac gtcggcgccg cccatcgccc atggtttcgc cgacgtgtgg
     9601 cggcgcacct gccagggcat gtcccccgcc tggcgcgcgc gctccgcccg gcactggcgc
     9661 aactacttct ccggatacgt cgacgaggcg gtgagccgcc acctcaacac cccctacgac
     9721 tcggccggtc actacctcgc catgcgcagg cagaccatcg gcgtgcagcc caccgtggac
     9781 ctggccgagc gcagctgcca ctgcgaggtg ccccagcggg tgttcgacag cgccgtgctg
     9841 ttcgcgatgc tccagatcgc caccgacacc aatctgatcc tcaacgacat cgcctccctg
     9901 gagaaggaag aggcccgcgg cgagctgaac aacatggtct tcatcctgat gcgcgagcac
     9961 ggctggacgc gcggccgcag catcgcgcac atgcaggacg gagtccgcac ccgcctcgaa
    10021 cagttcctgc tcctcgaggc ctgcctgccg aaggtctacg acaccttcga gctcactgcg
    10081 caggagcgcg agagcgcgga gaagtaccgg atggacgggg tgcgttcggt gatccggggg
    10141 tcgtacgact ggcaccgcag ctcgggccgg tacgccgccg actacgcgat cgccgccagc
    10201 taccagggct acctcgagga gctgggcagc acgctgtagc cgcccaggag ttgaccagcg
    10261 cacggagcca gcaatcgagg aagtcgagga ttccgatgtc ccagcacacc ttcgtcgccg
    10321 gaacggcccc cggggccgtg cccgtagtgg ggcacgcctg gcagatgatg cgccgccccc
    10381 tgcacttcat gtcctcgctg tccgcgcacg gcgacctggt gaagatacgc attggcccga
    10441 cgtccgccta tgtgccctgc caccccgagc tgctgcggca ggtactgacc aacgaccgcg
    10501 tcttcgacaa gggaggagtg ttctacgacc gcgcccggga catcgccggc aacggtcttg
    10561 tcacctgccc ctaccgcgac caccgcaggc agcggcgcct gatgcagtcg gccttccagc
    10621 gcacgcagct ggagcggtac tccacggcga tgcgcgcgga gatcgacgcc acggcggcgc
    10681 ggtggcacga cggcacggtc atcgacgcct tccccgagct gtacgggatg gcgctgcgca
    10741 ccgtggcccg cacgctgtac tccaccccgg tcaccgagga actggcacag cgcgtcgaac
    10801 aggcctttga caccgtactc aacgggctct tccgccagat gttcctgccc cactccctgc
    10861 ggcggctgcc gaccccggcc aacctccgct accgcaacaa cctgcgcttc ctgcacgaca
    10921 ccgtgcagga cctgatcacc gagtaccggc gggacgacac ccagcgcgac gacctgctgt
    10981 ccgcgctgct ggcgtcccgt gacgaggacg gcggacggct gggcgacacg gagatccacg
    11041 accaggtcat caccgtgatg gcggccggaa ccgagacggt cgccggcacc ctcacctgga
    11101 tcttccatct gctctcccgg catcccgaga tcgaggcgag gctgtacgag gagatcgaca
    11161 ccgtcctaga cggaaagccc ccgcactggg acgacctgcc gagcctgtcc ctgacggacc
    11221 ggatcatcac cgaagcgctc cggatgtatc cgccggcctg gatcttcacc cggctcaccg
    11281 cgtcggacgt cgacctcgcg ggggtgcgcc tgcccgaggg caccaccatc gtcttcagcc
    11341 cctcctccgt gcagcgtcac tcggaggcct acgacgacgc gtcccggttc gaccccgacc
    11401 gctggctgcc cgaccgcacc tcggccgtcg cccggcaggc gttcacggcg ttcggcaccg
    11461 gcgcgcgcaa gtgcatcggc gacctgttcg cgcggaccga ggccaccctc gcgctcgcca
    11521 cgatgctgag ccagtggcgg gtcaccgtgg agcccgacgc ggacgtccgg cccgtcgccc
    11581 tggccaccgt gtaccacccg cgccgcctgc gcctgcggct gacggcccgt acgccgggtc
    11641 agtagccggg agacgacgcg gctcgtgccg gggcgttgtc ggtgccccgt gccatcctga
    11701 tggcatggcg aatctggagg acctggtcag gttgcggaag gcgcgcgacc ggatggaccg
    11761 cgagtacgcc gagcagctgg acatagcggc gctcgcgcgg acggcgctga tgtcgccggg
    11821 ccacttccag cgcagcttcc gggcggcctt cggcgagacg ccgtacagct atctgatgac
    11881 gcggcggatc gagcgggcga aggcgctgct gcggcggggc gacctgacgg tgacggaggt
    11941 ctgtctggcc gtggggtgca cctcgctggg ctcgttcagt tcgcgcttca cggagctggt
    12001 gggcgagacg ccgagcgcgt accgggcgcg gtcgcacgaa cacggggcac ccatcccgcc
    12061 gtgcgtggcg aagggcctca cccgcccgag acggggccgc cccgtgtacg ggcgggcaga
    12121 tacggcaggc gggacatgga cgacagggcc tagcgtgacc tcatgaacat ggacaccgat
    12181 ccgggcgtga tgctctcgca gtgcttcatc gccgtcgacg accacgacaa ggcactcgcg
    12241 ttctaccgtg acgtcctcgg cctggaggtc cgcaacgacg tgggcttcga gggcatgcgc
    12301 tgggtgacgg tcggctcgcc gctccagccg gacgtggaga tcgtcctgga gccgccgggg
    12361 gcgaacccgg acgcgtccga agcggaccgg caggcgatgg ccgagctgct ggccaagggc
    12421 atgctgcggg gggtcatctt ctcgacgccg gactgcgacg ccctgttcgc ccgcgtcgag
    12481 gcgtccggcg ccgaggtcct gcaagagccc atggaccagc cgtacggcgt gcgcgactgc
    12541 gccttccgcg atccggcggg caacctcctg cgcttcaagc agcgctccgc cgcctgacgc
    12601 ggaaacctcg ttgcgcgggc gggccgggcg ggagacggta cgaggccatg tacacggtgg
    12661 ggggccatgg cccccgtccg gcccggcagg gagcgatcca tgagtgaacc gatccgttgg
    12721 gcgtacgcct tcgtcgaccg gcccgcggcg gagttcgtcc gggccgttga cttctggacc
    12781 gccgtcacgg cgaccgagcg gtccgaatcc cgcggcgacc agggcgagtt cgtgtcgctg
    12841 ctgccggggg cgggcgacgc gtgcgtgaag gcgcaggggg tgcgggacgg taccgggggc
    12901 gcccacctcg acctcgccgt cgcaaacgtg ccggcgctcg tcggggcggc gcggcggctc
    12961 ggcgccgagg tcgtcgccga gcatccgggg tgggccgtac tgcgctcccc cggcggccag
    13021 ttgttctgcg cggtcccctg gcacggcgag tcggcgcggc cgcccgtcgt cgagggcagc
    13081 cgcctcgacc agctgtgcat cgacctcgcc ccggcggtgt acgacctcga cgtcgcgttc
    13141 tggagcgacc tcaccggctg gacctcccac cccggcgccc tcccggagtt ccacctggtc
    13201 aggccgcccg aggggctgcc gatccgtatt ctcctccagc gcctgggcac cgatcgcccc
    13261 acctccgccc acctcgacct cgcctgcgcg gacatcgagg cgacacgggt ccggcacgag
    13321 gagctgggcg ccacgctcgt cgcccgcggc gcccggtgga cggtgctgcg cgaccccgcg
    13381 ggcggaacgt actgcctgac ggcccgcgac ccggaaacgg gcagcctgcc ggcctag
//
