BGC0000678: pentalenolactone biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
Location: 3,743,107 - 3,765,735 nt. (total: 22,629 nt).
This entry is originally from NCBI GenBank BA000030.3.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000678
Short description pentalenolactone biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
BA000030.3
3745497 - 3758933
via
Compounds
  • pentalenolactone
Species Streptomyces avermitilis MA-4680 = NBRC 14893 [taxonomy]
References
Chemical products information
pentalenolactone Evidence: NMR [1], X-ray crystallography [5]
Copy SMILES
C15H16O5
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAV_2990
  • BAC70701.1
  • gap1
3745497 - 3746501 (+) glyceraldehyde-3-phosphate dehydrogenase
    copy AA seq
    copy Nt seq
    • SAV_2991
    • BAC70702.2
    • ptlH
    3746862 - 3747719 (+) 1-deoxypentalenic acid 11-beta hydroxylase; Fe(II)/alpha-ketoglutarate dependent hydroxylase
      copy AA seq
      copy Nt seq
      • SAV_2992
      • BAC70703.1
      • ptlG
      3747777 - 3749231 (+) putative transmembrane efflux protein
        copy AA seq
        copy Nt seq
        • SAV_2993
        • BAC70704.1
        • ptlF
        3749307 - 3750119 (+) 1-deoxy-11beta-hydroxypentalenic acid dehydrogenase
          copy AA seq
          copy Nt seq
          • SAV_2994
          • BAC70705.1
          • ptlE
          3750177 - 3751961 (+) Oxidase
          • Oxidation
          copy AA seq
          copy Nt seq
          • SAV_2995
          • BAC70706.1
          • ptlD
          3751962 - 3752882 (+) Dehydration|Oxidation
          • Dehydration
          • Oxidation
          copy AA seq
          copy Nt seq
          • SAV_2996
          • BAC70707.1
          • ptlC
          3752934 - 3753110 (+) hypothetical protein
            copy AA seq
            copy Nt seq
            • SAV_2997
            • BAC70708.1
            • ptlB
            3753107 - 3754120 (+) polyprenyl diphosphate synthase
              copy AA seq
              copy Nt seq
              • SAV_2998
              • BAC70709.1
              • ptlA
              3754725 - 3755735 (+) pentalenene synthase
                copy AA seq
                copy Nt seq
                • SAV_2999
                • BAC70710.1
                • ptlI
                3755792 - 3757141 (+) Oxidase
                • Oxidation
                copy AA seq
                copy Nt seq
                • SAV_3000
                • BAC70711.1
                • ptlR
                3757201 - 3757662 (+) putative AraC-family transcriptional regulator
                  copy AA seq
                  copy Nt seq
                  • SAV_3001
                  • BAC70712.1
                  • ptlJ
                  3757659 - 3758093 (+) putative lyase
                    copy AA seq
                    copy Nt seq
                    • SAV_3002
                    • BAC70713.1
                    • ptlL
                    3758163 - 3758933 (+) hypothetical protein
                      copy AA seq
                      copy Nt seq
                      Biosynthesis information

                      No biosynthesis information available for this record.

                      Annotation changelog

                      Entry version: 5

                      Date
                      Changes
                      Submitters
                      Reviewers
                      MIBiG v4 annotathon
                      • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                      • (ID: IX2YLYLJIFMZ56AG4LPOYV2J)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Updated bioactivity data
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      Submitted
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Similar known clusters from MIBiG 4.0
                      Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                      Detailed help and explanations are available here.

                      Click on reference genes to show details of similarities to genes within the current region.
                      Double click on a reference drawing to reverse the display of the genes.

                      Click on an accession to open that entry in the MIBiG database.


                      Location:

                      Identifier
                      Identity
                      Coverage