BGC0000678: pentalenolactone biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
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Location: 3,745,497 - 3,758,933 nt. (total: 13,437 nt).
This entry is originally from NCBI GenBank BA000030.3.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000678
Short description pentalenolactone biosynthetic gene cluster from Streptomyces avermitilis MA-4680 = NBRC 14893
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • terpene (Unknown)
Loci
BA000030.3
3745497 - 3758933
via
Compounds
  • pentalenolactone
Species Streptomyces avermitilis MA-4680 = NBRC 14893 [taxonomy]
References
Chemical products information
pentalenolactone Evidence: NMR [1], X-ray crystallography [2]
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C15H16O5
Chemical database entries
PubCHEM
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SAV_2990
  • BAC70701.1
  • gap1
 3745497 - 3746501 (+) glyceraldehyde-3-phosphate dehydrogenase
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    • SAV_2991
    • BAC70702.2
    • ptlH
    		 3746862 - 3747719 (+) 1-deoxypentalenic acid 11-beta hydroxylase; Fe(II)/alpha-ketoglutarate dependent hydroxylase
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      • SAV_2992
      • BAC70703.1
      • ptlG
      		 3747777 - 3749231 (+) putative transmembrane efflux protein
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        • SAV_2993
        • BAC70704.1
        • ptlF
        		 3749307 - 3750119 (+) 1-deoxy-11beta-hydroxypentalenic acid dehydrogenase
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          • SAV_2994
          • BAC70705.1
          • ptlE
          		 3750177 - 3751961 (+) putative monooxygenase
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            • SAV_2995
            • BAC70706.1
            • ptlD
            		 3751962 - 3752882 (+) putative dioxygenase
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              • SAV_2996
              • BAC70707.1
              • ptlC
              		 3752934 - 3753110 (+) hypothetical protein
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                • SAV_2997
                • BAC70708.1
                • ptlB
                		 3753107 - 3754120 (+) polyprenyl diphosphate synthase
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                  • SAV_2998
                  • BAC70709.1
                  • ptlA
                  		 3754725 - 3755735 (+) pentalenene synthase
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                    • SAV_2999
                    • BAC70710.1
                    • ptlI
                    		 3755792 - 3757141 (+) pentalenene C13 hydroxylase; cytochrome P450
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                      • SAV_3000
                      • BAC70711.1
                      • ptlR
                      		 3757201 - 3757662 (+) putative AraC-family transcriptional regulator
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                        • SAV_3001
                        • BAC70712.1
                        • ptlJ
                        		 3757659 - 3758093 (+) putative lyase
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                          • SAV_3002
                          • BAC70713.1
                          • ptlL
                          		 3758163 - 3758933 (+) hypothetical protein
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                            Biosynthesis information
                            Annotation changelog

                            Entry version: next

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2024-04-23
                            MIBiG v4 annotathon
                            • (ID: P75FRHHCFPTCPYSP65VDVPHW)
                            • (ID: IX2YLYLJIFMZ56AG4LPOYV2J)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 4

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-10-07
                            Update chemical activity to schema version 2.11
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 3

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2022-09-15
                            Updated bioactivity data
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 2

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2019-10-16
                            Migrated from v1.4
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                            Entry version: 1

                            Date
                            Changes
                            Submitters
                            Reviewers
                            2015-06-12
                            Submitted
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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