LOCUS       BGC0000690             25459 bp    DNA     linear   BCT 15-APR-2005
DEFINITION  Streptomyces glaucescens GLA.0 gene cluster for
            5'-hydroxystreptomycin biosynthesis.
ACCESSION   BGC0000690
VERSION     BGC0000690
KEYWORDS    .
SOURCE      Streptomyces glaucescens
  ORGANISM  Streptomyces glaucescens
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:03:18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 25459
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..25459
                     /db_xref="taxon:1907"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces glaucescens"
                     /strain="ATCC 13032 (GLA.0)"
     subregion       1..25459
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="saccharide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..25459
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(14..1789)
                     /gene="strW"
     CDS             complement(14..1789)
                     /codon_start=1
                     /db_xref="GOA:Q54204"
                     /db_xref="InterPro:IPR001140"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="UniProtKB/TrEMBL:Q54204"
                     /function="putative transport of
                     5'-hydroxydihydrostreptomycin phosphate"
                     /gene="strW"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 308.8; E-value:
                     1.3e-93)"
                     /gene_kind="transport"
                     /product="StrW"
                     /protein_id="CAA07371.1"
                     /transl_table=11
                     /translation="MSRTRLPVAGTAEVRAHGAALARRHARDLTWMLALHGLAAVCGLL
                     GPWLIGRLLDEVVRGTTLSTVDHIGIALLLSLVAQAVLTYWAVQRSCRFGEKVTAEVRE
                     DFVDRVVRLPLPTVEDAEPGDLITRASRDTDALTNTVRYGVPETLIALMTCLFTFAALV
                     LVGPLTALPSLVVVPLLWAGTRWYLRRSQAAYRRRGASYTALGDTLAETVPGARTVEAL
                     RLQAWRRRALDRDLAEAYEAERHTMCWRSSWYLTVELSYVVPVVATLAIGGLLYTQGLA
                     TVGQAVAATLYVRQLIFPLDDVLSWMDELQIGSASLARVLGVSELPDDRRPSGARPDGR
                     QLTARSAGYSYVPGRDILHGVDLDLAPGERLAVVGPSGSGKSTLGKLLAGVYEPVSGTV
                     ELGGVRLVDLGTEELRRRIALVTQDHHIFRGHLRENVTLARPAADDEVEHALKAVGAAE
                     WAAALPDGPETVVGSGGHQLTAAQAQQIALARLVLADPHTVVLDEATALVDPATARHTE
                     RALAAVLSDRTVIAIAHRLHTAQSADRIAVLENGRIKELGSHQELLAANAPTPPCGAYG
                     TAIELIAEIPRPVLA"
     CDS             complement(1786..3540)
                     /codon_start=1
                     /db_xref="GOA:Q54203"
                     /db_xref="InterPro:IPR001140"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR011527"
                     /db_xref="UniProtKB/TrEMBL:Q54203"
                     /function="putative transport of
                     5'-hydroxydihydrostreptomycin phosphate"
                     /gene="strV"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 531.4; E-value:
                     4.7e-161)"
                     /gene_kind="transport"
                     /product="StrV"
                     /protein_id="CAA07372.1"
                     /transl_table=11
                     /translation="MRPLPAADPGNPDIRSAARFLLWLAGRIAWPLSAAAFCGVLWLGS
                     QALMPVVIREAIDDGLVPGDMDAVLSWSAVLLGLGVVQAVSGTVRRRLNMYNSLSAGFR
                     TVQLVVGHANTLGATLERRVDEGELVSVGTSDMNALGHAFDIVGRTVGAVISVVLVSVV
                     LVRQSATLGMMLIVAVPAIVLTMGYTLRPLHRRQSAYRDLQGELTSRLTDVVAGLRVLR
                     GIGGETPFARSYRERSQRVRAAGARVAGAEALIRAAQVLLPGLLVGTVTWIGARAALDG
                     SVSPGELVAFYAYAAFLVEPLGIFTETADRFARAHVAARRVVTVLRMRPKARPEHADGP
                     MGTLATALVDETTGLTVTPGTFHVVVAPSAEGVRLADRLGGYDEAPVRHDGRLLTALAP
                     DEVRRRILVVDNRPRLFRGPLRASLDPHVTADDTAITAALRAAAAEDIVGLLPDGLDTD
                     ITADGRHFSGGQRHLVLARALLADPDVLIVVDPTSAVDAHTEDLIGRRLRAARSGRTTV
                     LVSSSPLLLNQADRVSFLSGGRVAAAGTHRELLAASEDYRLVIQRETGEAPPGPLPSTD
                     LVTRGSAE"
     gene            complement(join(1786..3540,3547..3552,3572..3577))
                     /gene="strV"
     regulatory      complement(3547..3552)
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="strV"
                     /regulatory_class="minus_10_signal"
     regulatory      complement(3572..3577)
                     /citation=[2]
                     /gene="strV"
                     /regulatory_class="minus_35_signal"
     gene            3587..3615
                     /gene="strV and strX"
     protein_bind    3587..3615
                     /bound_moiety="activator"
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="StrR binding site"
                     /gene="strV and strX"
                     /note="The expression of both the genes, strX and strV, is
                     activated by binding of the protein StrR"
     gene            3706..4254
                     /gene="strX"
     CDS             3706..4254
                     /codon_start=1
                     /db_xref="GOA:Q54202"
                     /db_xref="HSSP:P26394"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="UniProtKB/TrEMBL:Q54202"
                     /function="putative 5'-hydroxystreptomycin biosynthesis
                     protein"
                     /gene="strX"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /product="StrX"
                     /protein_id="CAA07373.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 8.9e-68,
                     bitscore: 217.8, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIHETPLAGAALIELSELRDERGFFSRSFCREEFERAGLEPAVV
                     QCNLSFNHRAGSLRGFHYQTEPNAEAKTIRCTRGAIYDVIVDLRPDSPTFLRHFGAELT
                     ADNRLALHVPRNFAHAYLTLADDTETVYQVSAAYTPGAERGLRWNDPALGVEWPAPVKL
                     VSDKDAGWPLLSEVPAGSR"
     gene            4251..5537
                     /gene="strU"
     CDS             4251..5537
                     /codon_start=1
                     /db_xref="GOA:Q54201"
                     /db_xref="InterPro:IPR005106"
                     /db_xref="UniProtKB/TrEMBL:Q54201"
                     /function="putative 5'-hydroxystreptomycin biosynthesis
                     protein"
                     /gene="strU"
                     /product="StrU"
                     /protein_id="CAA07374.1"
                     /transl_table=11
                     /translation="MIIVDTALRRREERDRPIRVGMVGAGFMGRGLARHIVRSVPGMRL
                     AAIANRSLATAERAYTEAGVRPVRANGAGDVEAAVAAGRPVVTEDAFALLAAEGIDCLV
                     DVTGAVEFGARVTVAALERGLPVVTMNAELDGTVGPLLAHRARAAGVVLTAADGDQPGV
                     QGNLLRFVRGLGVTPLVAGNVKGLQDEYRTPATQKAFAERWGQNVHMVTSFADGTKVSF
                     EQAIVANAHGLTVARRGMYGRGHTGHVDELTGVYDIDELRELGGVVDYVVGARPGPGVY
                     VIGTHDDPRQRHYLELYKLGKGPLYSFYTPYHLCHFEVPHTIARAVDFADAALTPPAGP
                     RVDVVATAKRDLKAGTVVDGIGGYDTYGVAETHAATLASRLLPMGVAEGCVLRRDIARD
                     AVLTYDDVRLPAGRLVDRLREEQNELFPG"
     gene            complement(5455..6354)
                     /gene="strQ"
     CDS             complement(5455..6354)
                     /citation=[2]
                     /codon_start=1
                     /db_xref="GOA:Q54266"
                     /db_xref="HSSP:P26396"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="UniProtKB/TrEMBL:Q54266"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="alpha-D-glucose-1-phosphate
                     cytidylyl-transferase"
                     /gene="strQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 139.5; E-value:
                     2.2e-42)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrQ"
                     /protein_id="CAA07375.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.3e-09, bitscore:
                     27.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVDSDIPVVLLCGGYGTRIREASERLPKAMVDIGGRPILWHIMK
                     IYSHYGFRRFVLCLGYKGWAIKQFFLDYRAQLSDFTISLSDEHRIRFHDDRADENCEIT
                     FAETGLDTATGARLRRVRRYVDTDDFMMGYGDGVGNIDLAALEKEHRAAGRIGTVTGIH
                     PTSKFGEMDVEDDQVLEFNEKPTRVTGFVSGGFFMFRREFLDDYLDDDPKLWLESAPLQ
                     RLARDRQLTLHPHHDFWCAMDTFKDYQHLNELWAAGDAPWKVWEQPGNRSVSPGTARSA
                     PRAAGRPAGPPAAVRRHR"
     gene            complement(6351..7427)
                     /gene="strP"
     CDS             complement(6351..7427)
                     /codon_start=1
                     /db_xref="GOA:Q54262"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="UniProtKB/TrEMBL:Q54262"
                     /function="putative protein involved in biosynthesis of
                     5'-hydroxystreptomycin"
                     /gene="strP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     226.9; E-value: 6.5e-69)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrP"
                     /protein_id="CAA07376.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.5e-18, bitscore:
                     56.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRILLTGHQGYLGTVMAPVLTAAGHQVTGLDSGLFASRVLGALDV
                     PDVPGLALDLRDVTVDTLRGYDAVVHLAALSNDPLGSLDPELTHAVNHHASTRLARLAK
                     EAGVTRFAYASTCSVYGAQSGDAPVDEDAPLKPVTPYAVSKVRVEDDLVELADSGFAPF
                     FLRNATAFGFSPRLRSDIVLNNLVGRAVLGGRVTVLSDGTAWRPLVHAEDIARAVLAGL
                     AAPAATVRARAFNIGTEENNRTVAEIAEAAAAAVPGSVVEISGETGNDPRSYRVDFTRA
                     RTELGHRATWTIPDGAAQLAREYRARGLTRAAFEHDFTRLAVLERRRREGSLDGDLRVR
                     PARVRRDGDHRTATAEEG"
     gene            complement(7522..8679)
                     /gene="strH"
     CDS             complement(7522..8679)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q54261"
                     /function="putatively involved in biosynthesis of
                     5'-hydroxystreptomycin"
                     /gene="strH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: strH"
                     /gene_kind="biosynthetic"
                     /product="StrH"
                     /protein_id="CAA07377.1"
                     /sec_met_domain="strH (E-value: 7.5e-247, bitscore: 808.7,
                     seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTSAHPAPARAADPSYEEALLSQDERFRTFLAGLPADTPVWFCF
                     FSSGLMHVIQHFLRFVPPRLNIAFVCSGLTDDEIRLRDTMSGGRPAFDLDERVGSHEIF
                     EFLLRNLDRPFGIVDSDCFVMDADWFTRCTDDLEPDVAVSSPLSYGPIPLAAPPFMAIN
                     PLARPEIERAIGGPVSPAAYSYTPPGPEKEIDGAMVRLIEPHHEAALAKVLAMEGPRLP
                     FPQGGLLDVLDDGREVRSHERHHHAQNGNGVIRVVFDGLMFYQLMALAAGWRIAHFHSF
                     PGTKVFSAQMVHAGGISYWHRLRPSEIAAGIHELPWSAHIDALLLENFTARPDAPPAYR
                     ARGTRLAANLRQSGTTLGRLRDDLRGKLASSGVDVTDPRWRAVLG"
     gene            complement(8802..9407)
                     /gene="strG"
     CDS             complement(8802..9407)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q54260"
                     /function="putatively involved in biosynthesis of
                     5'-hydroxystreptomycin"
                     /gene="strG"
                     /product="StrG"
                     /protein_id="CAA07378.1"
                     /transl_table=11
                     /translation="MAAFTRLHYDVGKIPLGDLVRKVLAVDDLEGLAASDRVATRETDQ
                     STDYHKRFYEAFDAVEPAYRELARTLLGADAEHHYIQRVPTFRVHLRNSLAVAVGDWHR
                     DSDFGHDPNEVNYWVPLTRAYGNNTVWIDKEPVRAEYGDVIVFDGANTWHGNVVNDTDI
                     SRVSMDFRTIPRDKYRPNDKKSVSFGMPFLLGEYWDVL"
     gene            complement(9417..10262)
                     /gene="strF"
     CDS             complement(9417..10262)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q54259"
                     /function="putatively involved in biosynthesis of
                     5'-hydroxystreptomycin"
                     /gene="strF"
                     /product="StrF"
                     /protein_id="CAA07379.1"
                     /transl_table=11
                     /translation="MIGYGVCVGPSDLFDRICRPGIERVRTPGSPLFTMRNQRSLFEAY
                     NAMFDQAAANSEVTGLVMLLDDVDVRKNPADVAAPVFEDDSVGMLGSLGGSDTVSLAWW
                     NEKATRRGRVTDYDKVHDYGSGLHEVHAVDDVILCVNRWVIENVRFPAGRYRGFEGLGV
                     ILASLVRAAGKRVMVQDLQDVMHHNAGRGFNGLKDWRYNELRWQRQFFDLGPLERVGSV
                     LEELTVPAVPLRIAARRLALRAAGRGFEESDGESGDPATDELVDGWYRRCTRLRGRMRI
                     "
     CDS             complement(10343..11389)
                     /codon_start=1
                     /db_xref="GOA:Q54258"
                     /db_xref="UniProtKB/Swiss-Prot:Q54258"
                     /function="L-arginine:scyllo-inosamine amidinotransferase
                     (putative)"
                     /gene="strB1"
                     /product="StrB1"
                     /protein_id="CAA07380.1"
                     /transl_table=11
                     /translation="MSLVSVHNEWDPLEEIIVGTAVGARVPRADRSVFAVEYADEYDSQ
                     DQVPAGPYPDRVLKETEEELHVLSEELTKLGVTVRRPGQRDNSALVATPDWQTDGFHDY
                     CPRDGLLAVGQTVIESPMALRARFLESLAYKDILLEYFASGARWLSAPKPRLADEMYEP
                     TAPAGQRLTDLEPVFDAANVLRFGTDLLYLVSDSGNELGAKWLQSALGSTYKVHPCRGL
                     YASTHVDSTIVPLRPGLVLVNPARVNDDNMPDFLRSWQTVVCPELVDIGFTGDKPHCSV
                     WIGMNLLVVRPDLAVVDRRQTGLIKVLEKHGVDVLPLQLTHSRTLGGGFHCATLDVRRT
                     GSLETYRF"
     gene            complement(10343..11704)
                     /gene="strB1"
     protein_bind    complement(11676..11704)
                     /bound_moiety="activator"
                     /citation=[1]
                     /function="transcriptional activation by StrR"
                     /gene="strB1"
     gene            complement(11786..12709)
                     /gene="strA (sph)"
     CDS             complement(11786..12709)
                     /codon_start=1
                     /db_xref="GOA:Q7B3E3"
                     /db_xref="InterPro:IPR006748"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="UniProtKB/TrEMBL:Q7B3E3"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="(5'-hydroxy)-streptomycin-6-phosphotransferase"
                     /gene="strA__sph_"
                     /gene_functions="resistance (resist) APH6 (Score: 396.6;
                     E-value: 4.2e-121)"
                     /gene_kind="resistance"
                     /product="StrA (Sph)"
                     /protein_id="CAA07381.1"
                     /transl_table=11
                     /translation="MSTSKLVEIPEPLAASYARAFGEEGQAWIAALPALVEELLDRWEL
                     TADGASASGEASLVLPVLRTDGTRAVLKLQLPREETSAAITGLRTWNGHGVVRLLDHDP
                     RSSTMLLERLDASRTLASVEDDDAAMGVLAGLLARLVSVPAPRGLRGLGDIAGAMLEEV
                     PRAVAALADPADRRLLNDWASAVAELVGEPGDRMLHWDLHYGNVLAAEREPWLAIDPEP
                     LAGDPGFDLWPALDSRWDDIVAQRDVVRVVRRRFDLLTEVLGLDRARAAGWTYGRLLQN
                     ALWDIEDGSAALDPAAVTLAQALRGH"
     gene            12860..14242
                     /gene="strK"
     CDS             12860..14242
                     /codon_start=1
                     /db_xref="GOA:Q54252"
                     /db_xref="HSSP:P00634"
                     /db_xref="InterPro:IPR001952"
                     /db_xref="UniProtKB/TrEMBL:Q54252"
                     /function="(5'-hydroxy)-streptomycin-phosphate phosphatase"
                     /gene="strK"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: strK1"
                     /gene_kind="biosynthetic"
                     /product="StrK"
                     /protein_id="CAA07382.1"
                     /sec_met_domain="strK1 (E-value: 2.6e-253, bitscore: 831.1,
                     seeds: 6, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVIPGTGRAARRSARRWGGVAAALVTALTVTSAAPAPRIGVTG
                     TEPARPRNVILLVGDGMGDSEITAARNYTVGAGGRLAMDRLPMTGSSLTYAVDERGRPD
                     YVTDSAAGATAWATGHKTVNGRVAKTPGTDRPLPTLLELARRQGYATGSVTTARLTDAT
                     PAALTAHVTDRSCAGPADMAACPADAKERGGAGSIAEQTVALRPDVLLGGGADVFGQRI
                     TAGPHRGRTVLERARAEGYQVVRDRTGLRAARPDRPVLGLFADGPLPVEWTGVPARPGG
                     TAPQRCGTGAPAHPAGTPSLEESTRAALELLTARARRAGAAAGGFFLQVEGAAIDDRAH
                     DADPCGQIGETVAFDRAVGQRWPMRTHPGTLVVVTDHGSGGQILPLEARPPGRSATLVT
                     DEGAPLHLGYASGAPDDVQEHTGVPVRVAARGPYAERVVGVHENTALFHTVRTALGLRS
                     IH"
     gene            14378..15514
                     /gene="strS"
     CDS             14378..15514
                     /codon_start=1
                     /db_xref="HSSP:Q8ZNF3"
                     /db_xref="InterPro:IPR000653"
                     /db_xref="UniProtKB/TrEMBL:O86863"
                     /function="putative aminotransferase in
                     N-methyl-L-glucosamine biosynthesis"
                     /gene="strS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     387.2; E-value: 1.4e-117)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrS"
                     /protein_id="CAA07383.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 4.4e-118,
                     bitscore: 385.1, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 7.3e-08, bitscore:
                     22.4, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 8.4e-09, bitscore:
                     25.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSVELPRWPQLSDDDVEAAVAALRANRLVGLGNPVVEQFESAL
                     AESQAVEHAVAVSTGTAAVHLALHALDVGPGDEVIVPAHTFIGSASPIAYLGARPVFAD
                     VTPDTHCLDPDSVKSLITERTKAIVVVHINGVAADMASLSAIATDAGVPLVEDMAQALG
                     TSIGGRPVGGFGDLACVSLFEQKVITSGGEGGAVLTNNPGYAERVRRLRSHGEGPIADR
                     PGLIWAYEVGYNYRLTAVQAAVGLSQHGRLGEMVEARRRNAAYLSERLADVEGLELPVE
                     PEGTVHAFWKYVVRAVPAGGRPTAAEIAATLRSRGVPVLLRYPFPLHKQPAFAEHQSVS
                     LPVAERLSQELLALPSHPALTERHLDHVAAEVRKAFTG"
     gene            15899..16858
                     /gene="strT"
     CDS             15899..16858
                     /codon_start=1
                     /db_xref="GOA:O86864"
                     /db_xref="InterPro:IPR001395"
                     /db_xref="UniProtKB/TrEMBL:O86864"
                     /function="putatively involved in biosynthesis of
                     5'-hydroxystreptomycin"
                     /gene="strT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     224; E-value: 4e-68)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrT"
                     /protein_id="CAA07384.1"
                     /transl_table=11
                     /translation="MSSVPLPVSSDASSQPDGAPPLLLGTSAFGQDERGFPVYDAYWEG
                     GGRAFDTAWLYGHAYGPGCCERTFGAWARSRGVEKEVWVLAKGAHTPECLPDRVEAQLA
                     ESFDRMGRDDAAMYMLHRDNPDVPVGEFVSVLADLVARGLIGAYGMSNWSLDRVREAVG
                     YAREQGLPAPAGVSNQLSLIDMVQPIYPGTMGSHDPRWRAWLTENPVTLYPWASQGRGA
                     HALADPAELRTSPLAECWYSETNVERLRRARTLAERRGVSSTGIALAWTLSQPFRVVAL
                     IGPRQPEEVRDSLAAAELRLTEAERDWLENGTGEPPRE"
     gene            complement(17068..18342)
                     /gene="strR"
     CDS             complement(17068..18342)
                     /codon_start=1
                     /db_xref="GOA:Q54267"
                     /db_xref="InterPro:IPR003115"
                     /db_xref="UniProtKB/TrEMBL:Q54267"
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="DNA-binding protein and regulator of
                     5'-hydroxystreptomycin biosynthesis"
                     /gene="strR"
                     /product="StrR"
                     /protein_id="CAA07385.1"
                     /transl_table=11
                     /translation="MELSSRRQFDMHDLSSRGVSELNGNSAKLSGVVMVPIASLRPSDS
                     PRSAGEDPEHIRALAESGAELPPIIVMASTMRVVDGMHRLRAAELRGESELAVRFFEGD
                     EKEAFVLAVEANITHGLPLGLQDRKDAAARILRSHPMWSDRAIGTATGLSAKTVAALRA
                     RSTEGLPQSNVRIGRDGRARPVDPAEGRRLAGRLMQENPSAPLRQIAAQAGVSLGTVSD
                     VRKRLQRGEGPVPERGRARTEPGTNPEPAHTPERPYDEAEAERPSRALILRHLSRDPSV
                     RLTEDGRTLLRWLTVAAVRPQDWERLLRNVPAHRVGAVAELARGCSQTWQLVAEQLERA
                     RGSGAEQETGGAPGRQEAEGAGQSAAGMPRRAAALESRRTGEVTVQVPDAPDRPVPPAD
                     PCCDTVLRGPASAGAPGRRTPRAGR"
     protein_bind    complement(17824..17852)
                     /bound_moiety="regulator"
                     /citation=[1]
                     /function="binding site for StrR"
                     /gene="strR"
     gene            18796..19866
                     /gene="strD"
     CDS             18796..19866
                     /codon_start=1
                     /db_xref="GOA:O86865"
                     /db_xref="HSSP:P61887"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005908"
                     /db_xref="UniProtKB/TrEMBL:O86865"
                     /function="dTDP-glucose synthase involved in
                     5-hydrosystreptomycin biosynthesis"
                     /gene="strD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 326.1; E-value:
                     3.2e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrD"
                     /protein_id="CAA07386.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.3e-11, bitscore:
                     35.6, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLAGGAGPRLRPITHTSAKQLVPVANKPVLFYGLEAIAAAG
                     ITDVGIVVGDTVAEITEAVGDGSKFGLDVTYIPQRKPLGLGHGVRISRDYLGDDDFAMY
                     LGDNFVVGGIDQPIRAFRTHRPDAHLLLTRVSDPRSFGVAELDERGRVRHLEEKPTHPG
                     SDLALVGVYLFSPAIHEAVRAIEPSWRGELEITHAVQWLIDEGKDVRSTLISGYWKDTG
                     NVTDMLEVNRLVLETVEPRCDGDVDEDSELIGRVRVDEGAVIRNSRVIGPVVVGSGTTI
                     TDSYVGPFTSIAEGCLVEDQPSWSSPFVLRNASISGVRRIEASLIGRHVRVTAAPPVPH
                     AHRLVLGDHSTAQISS"
     gene            19909..20898
                     /gene="strE"
     CDS             19909..20898
                     /NRPS_PKS="Domain: NAD_binding_4 (6-182). E-value: 1.6e-15.
                     Score: 48.8. Matches aSDomain:
                     nrpspksdomains_strE_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GOA:O86866"
                     /db_xref="HSSP:P27830"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="UniProtKB/TrEMBL:O86866"
                     /function="dTDP-glucose dehydratase involved in
                     5'-hydroxystreptomycin biosynthesis"
                     /gene="strE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     325.2; E-value: 7.2e-99)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrE"
                     /protein_id="CAA07387.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.2e-19, bitscore:
                     60.1, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 8.2e-17,
                     bitscore: 51.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 6.2e-16, bitscore:
                     48.8, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATRLLVTGGAGFIGSHYVRTLLGPDGPPDAVVTVLDALSYAGNL
                     ANLDPVRDHPPVRFVHGDICDADLVRVMAGQDQVVHLAAESHVDRSLLDAAAFVRTNAG
                     GTQTLLDAALRHGVAPFVQVSTDEVYGSLETGSWTEDEAVRPNSPYAASKASGDLLALA
                     MHVSHGLDVRITRCSNNYGPYQFPEKLVPRFVTLLLEGRKVPLYGDGLHVRDWLHVDDH
                     VRGIEAVRARGRAGRVYNIGGGTSLANRDLVDLLLKACGAGWDRVEHVPDRKGHDRRYS
                     VDASRIRRELGHVPATDLSTGLAATVAWYRDNRAWWEPLCAGRAPQTA"
     aSDomain        19927..20454
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_strE_NAD_binding_4.1"
                     /evalue="1.60E-15"
                     /label="strE_NAD_binding_4.1"
                     /locus_tag="strE"
                     /protein_end="182"
                     /protein_start="6"
                     /score="48.8"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHYVRTLLGPDGPPDAVVTVLDALSYAGNLANLDPV
                     RDHPPVRFVHGDICDADLVRVMAGQDQVVHLAAESHVDRSLLDAAAFVRTNAGGTQTLL
                     DAALRHGVAPFVQVSTDEVYGSLETGSWTEDEAVRPNSPYAASKASGDLLALAMHVSHG
                     LDVRITRCSNNYG"
     gene            21052..21969
                     /gene="strL"
     CDS             21052..21969
                     /codon_start=1
                     /db_xref="GOA:O86867"
                     /db_xref="HSSP:P26392"
                     /db_xref="InterPro:IPR005913"
                     /db_xref="UniProtKB/TrEMBL:O86867"
                     /function="involved in biosynthesis of 5'-dihydrostreptose"
                     /gene="strL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     100.2; E-value: 2.4e-30)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrL"
                     /protein_id="CAA07388.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.4e-112,
                     bitscore: 366.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPLGSRWLVTGASGMLGRELTARLSRRGVPVVPLVRRADLDVT
                     DPAAARALLARHRPAVLVNCAAWTAVDAAEAHEARALAVNGEGPGHLARACRATGTRMI
                     QLSTDYVFAGLADRPYREDDPPAPRTAYGRTKLAGERAVLDTLPDGGYVVRTAWLYGSG
                     GANFVSTMIRLAAAEGTVPVVDDQHGGPTWTGDLADRLLALGAAALRGTAPPGVYHAVN
                     AGSTTWHALAREIFRRAGADPGRVRPIGSGELARPAARPPYSVLAQGRWRAAGLAPLRD
                     WRAALAEAFPALLRASARGGTVRR"
     gene            complement(21959..22561)
                     /gene="strM"
     CDS             complement(21959..22561)
                     /codon_start=1
                     /db_xref="GOA:Q54265"
                     /db_xref="HSSP:Q9L9E5"
                     /db_xref="InterPro:IPR000888"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="UniProtKB/TrEMBL:Q54265"
                     /function="dTDP-4-keto-L-rhamnose 3,5-epimerase"
                     /gene="strM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /product="StrM"
                     /protein_id="CAA07389.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 3.3e-61,
                     bitscore: 196.4, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPLGIEGAWLVESRVFGDERGEFQELFRGGPLSDTLGYVPGVAQ
                     VNRSVSRKGVVRGVHFADVPPGQAKYVTCLRGAVLDVVVDIRAGSPAYGAWETVRLDDP
                     RRSVYIEAGLGHAFMALTDDATVVYLTSEGYAPEREHAVHPLDPALGIAWPPGIEPVLS
                     AKDSRAPGLEESALRGLLPDYHTCADFHRELRRRFTA"
     gene            complement(22592..23551)
                     /gene="strB2"
     CDS             complement(22592..23551)
                     /codon_start=1
                     /db_xref="GOA:Q54264"
                     /db_xref="UniProtKB/Swiss-Prot:Q54264"
                     /function="putative amidinotransferase involved in
                     5'-hydroxystreptomycin biosynthesis"
                     /gene="strB2"
                     /product="StrB2"
                     /protein_id="CAA07390.1"
                     /transl_table=11
                     /translation="MSLAGVYTEWDPLEEIVVGTAVGSENRMVRETEDELDGLCEELRG
                     LGVTVRRLPPQDPASPPAPPDRGADTALAYRPRDGLLTVGETVIQTPAVPGLPSLQSPA
                     CRMLLMEYFTSGSRWISAPPPVLTDVMYDPTAPAGERLRELEPVFDADTVLRIGTDLLY
                     LVSDSGNALGARWLQAALGERYTVHPCRGPHGSPHGDFAVVPLGPGLILVNPERVDAEH
                     IPPFLRTWKRIVCPELVDPGPPDGAVHSSGWGGSNILVVRPGLVIVDRRQADLMRVLEN
                     NGIDVLPLQLTHARALGSGFHRVTVDVRRTGTLESYRF"
     gene            complement(23615..24562)
                     /gene="strN"
     CDS             complement(23615..24562)
                     /codon_start=1
                     /db_xref="GOA:Q54263"
                     /db_xref="InterPro:IPR002575"
                     /db_xref="InterPro:IPR011009"
                     /db_xref="UniProtKB/TrEMBL:Q54263"
                     /function="putative phosphotransferase involved in
                     5'-hydroxystreptomycin biosynthesis"
                     /gene="strN"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /product="StrN"
                     /protein_id="CAA07391.1"
                     /sec_met_domain="APH (E-value: 5e-27, bitscore: 85.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAFGMLLENELVDRRNLVRLVAEKFRDVVPIDETTHRLEFFPLG
                     EDSWSYRYGPLWISVRRDLDGHFPGAYEAALLLRRAGKHFVLAPLAAGDGGVVHDLSGL
                     PVVVFPYVERATARRVPPTPAQLDLLVARLTEVHGFATPGGLPAEVPVEDFGFPFEGDL
                     EKALRTALEGDTDHLGPYGSRLTRLVTGCRDRVAELRREAARVAAECAARWEGEPPALT
                     HGDPSPANVLFGDGVDILDWGSTMWAPPERDWAAVARAFGTAPDGRGLFLRFYELRWQL
                     AEIAEYTARFAAPHTGDADDHAMWGRLLRYLPAG"
     gene            24653..25423
                     /gene="strO"
     CDS             24653..25423
                     /codon_start=1
                     /db_xref="GOA:P72460"
                     /db_xref="InterPro:IPR000760"
                     /db_xref="UniProtKB/TrEMBL:P72460"
                     /function="putative N-amidino-scyllo-inosamine-4-phosphate
                     phosphatase"
                     /gene="strO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207:inositol monophosphatase (Score: 206.2; E-value:
                     1.2e-62)"
                     /gene_kind="biosynthetic-additional"
                     /product="StrO"
                     /protein_id="CAA07392.1"
                     /transl_table=11
                     /translation="MENDSDVLLAHRLVDVADALSLRYFGRTPASRQKADGSPVSEADL
                     AVEEALLEILAVERPGDAVLSEESGTRSAAARRWIIDPIDGTIPFLAGRRDWGTHVALE
                     VGGELRIGVLSRPTEGLRWWARQGGGAYASSAGGPCRRARRLRVEPSRVPLGRARVGGF
                     LFAGSPFEAVRERVRWVESSVCLVADLLEGRVEGIVDEGGHVWDRAPAALLVREAGGRV
                     DDLHGGHRLDRPWLVYGADGLAPRLAGLVRSVAG"
ORIGIN
        1 gaattcatga cggtcaggct aggaccggac gcgggatttc ggcaatgagt tcaatcgccg
       61 tgccatacgc gccacagggc ggcgtaggcg cgttcgcggc caggagttcc tgatgacttc
      121 cgagttcctt tatccggccg ttctccagca cggcgatccg gtcggcgctc tgcgcggtgt
      181 gcagccggtg cgcgatggcg atgacggtgc ggtcgctcag tacggcggcg agggcgcgct
      241 cggtgtgccg ggcggtggcc gggtccacca gcgcggtggc ctcgtcgagg accacggtgt
      301 gcgggtcggc gaggaccagc cgggccagcg cgatctgctg cgcctgggcg gcggtcagct
      361 ggtggcctcc ggagccgacc accgtctccg gtccgtcggg cagggccgcc gcccactccg
      421 cggcaccgac cgccttcagc gcgtgctcga cctcgtcgtc ggcggcgggc cgggcgagcg
      481 tgacgttctc ccgcaggtgc ccgcggaaga tgtggtggtc ctgggtgacc agcgcgatac
      541 ggcgtctgag ttcctcggtg ccgaggtcga ccagtcgcac gccaccgagt tcgacggtcc
      601 cggagaccgg ttcgtagacg ccggccagga gtttgccgag ggtggacttc ccggaaccgg
      661 acgggccgac cacggccagc cgctccccgg gggcgagatc caggtcgacg ccgtgcagga
      721 tgtcgcggcc cggcacgtac gagtagccgg ccgagcgggc ggtgagctgc cggccgtcgg
      781 ggcgggcgcc gctggggcgg cggtcgtcgg ggagttcgct gacgccgagc acccgggcga
      841 gcgaggcgga gccgatctgg agttcgtcca tccagctcag cacgtcgtcc agcgggaaga
      901 tcagctgccg tacgtagagc gtggccgcga cggcctggcc cacggtggcc aggccctggg
      961 tgtagagcag cccgccgatc gccagggtcg ccacgacggg gacgacgtag ctgagctcga
     1021 ccgtcaggta ccaggagctg cgccagcaca tcgtgtgccg ttcggcttcg taggcctcgg
     1081 cgaggtcgcg gtcgagggcg cgccgccgcc atgcctggag ccgcagcgcc tcgaccgtgc
     1141 gggcgccggg aaccgtctcc gcgagggtgt cgccgagcgc ggtgtagctg gcgccgcggc
     1201 gccggtaggc ggcctgcgac cggcgcaggt accagcgcgt gccggcccac agcagcggga
     1261 cgacaacgag gctgggcagc gcggtgaggg ggccgaccag caccagcgcc gcgaaggtga
     1321 acaggcaggt catcagtgcg atcagggttt cgggcactcc gtagcgcacg gtgttggtga
     1381 gcgcgtcggt gtcgcgggag gcccgggtga tgaggtcgcc gggctcggcg tcctccacgg
     1441 tcggcagggg cagccggacg acgcggtcga cgaagtcctc gcggacctcg gcggtgacct
     1501 tctcgccgaa ccggcaggag cgctgcaccg cccagtaggt caggacggcc tgtgccacca
     1561 gggacagcag cagggcgatc ccgatgtggt cgacggtgct gagggtggtg ccccggacga
     1621 cctcgtcgag gaggcgtccg atcagccagg gcccgagcag gccgcagacg gcggccagcc
     1681 cgtgcagggc cagcatccag gtgaggtcgc gggcgtgacg gcgggccagc gccgctccgt
     1741 gcgcccggac ttcggcggtg ccggcgacgg gcagccgggt ccggctcatt cggcgctccc
     1801 ccgggtcacg aggtcggtgg acggcagggg cccgggcggg gcctcgccgg tctcgcgttg
     1861 gatgacgagg cggtagtcct cgctggccgc gagcagttcc cggtgggtgc cggccgccgc
     1921 gacccggccg ccggacagga aggagacccg gtcggcctgg ttgagcagca gcgggctgga
     1981 gctgacgagg acggtggtgc ggccggaccg ggcggcgcgc agccgtcgcc ctatgaggtc
     2041 ctcggtgtgc gcgtcgaccg ccgaggtggg gtcgaccacg atgagcacgt cggggtcggc
     2101 gagcagggcg cgggccagga ccaggtggcg ctggccgccg gagaagtggc ggccgtcggc
     2161 ggtgatgtcg gtgtcgaggc cgtcgggcag gaggccgacg atgtcctcgg cggcggccgc
     2221 ccggagggcc gcggtgatgg cggtgtcgtc tgccgtcacg tgcgggtcga ggctcgcgcg
     2281 cagcggtccg cggaagagcc ggggccggtt gtcgacgacc aggatgcggc ggcggacctc
     2341 gtcgggggcc agcgcggtga ggagccggcc gtcgtggcgg acgggggcct cgtcgtatcc
     2401 gccgagccgg tcggcgagcc gcacgccctc cgccgagggt gccacgacga cgtggaaggt
     2461 tccgggggtg accgtgaggc cggtggtctc gtcgacgagc gcggtggcca gggtgcccat
     2521 gggcccgtcg gcgtgctcgg ggcgtgcctt cggccgcatg cgcaggacgg tgaccacgcg
     2581 gcgggcggcg acgtgggcgc gggcgaaccg gtcggcggtc tcggtgaaga tgcccagcgg
     2641 ctcgacgagg aaggccgcgt aggcgtagaa ggcgaccagt tcgcccgggg agacgctgcc
     2701 gtcgagcgcc gcgcgcgcgc cgatccatgt gacggtgccg accagcagac cgggcagcag
     2761 cacctgggcc gcgcggatca gggcctccgc gccggcgacc cgggcgcccg cggcccgtac
     2821 ccgctgcgag cgttcccggt aggagcgggc gaagggcgtc tcgccgccga tgccgcgcag
     2881 gacgcgcagt cccgcgacca cgtcggtgag ccgggaggtc agttcgccct ggaggtcgcg
     2941 gtaggcgctc tgccggcggt gcagcggccg cagggtgtag cccatggtga ggacgatcgc
     3001 ggggaccgcg acgatcagca tcatgccgag ggtggcggac tgccggacca agacgaccga
     3061 gaccaggacg accgagatca cggcgccgac ggtccgtccg acgatgtcga aggcgtggcc
     3121 cagcgcgttc atgtccgagg tgccgacgct gaccagctcg ccctcgtcca cccgccgctc
     3181 cagggtggcg ccgagggtgt tggcgtgccc gaccacgagc tgcacggtgc ggaagccggc
     3241 ggagagggag ttgtacatgt tgagacggcg gcggacggtt ccggagacgg cctggaccac
     3301 gccgagtccg agcaggacgg ccgaccagga caggacggcg tccatgtcgc cgggcaccag
     3361 tccgtcgtcg atggcctccc ggatgaccac cggcatgagc gcctgggagc cgagccacag
     3421 cacgccgcag aacgcggcgg cgctcagcgg ccaggcgatg cgacccgcga gccacagcaa
     3481 aaaccgtgcg gctgaacgaa tatccggatt tcctgggtct gcggcaggta acgggcgcat
     3541 tgcgcaatga taccgagccc ggcggacggt gcgtcaacca ggagccgttc gagtgcggga
     3601 agtgagcagt tgaacgtttc tccggatagc cgcacctgtc acccgtggct gccactgtgt
     3661 agcttcgtca ttccgcaggc aacccgacgg agggaaatat cacccgtgtt gattcatgaa
     3721 actccgctgg ccggcgccgc tctcatcgaa ctgagcgaat tgagggacga aagggggttc
     3781 ttctcccgct cgttctgccg ggaggagttc gagcgggcgg gactggagcc cgccgtggtc
     3841 cagtgcaatc tctcgttcaa ccaccgcgcc ggcagcctcc gcggattcca ctatcagacg
     3901 gagccgaacg ccgaggcgaa gacgattcgc tgcacgcgcg gcgcgatcta cgacgtgatc
     3961 gtcgatctgc gtcccgactc ccccacgttc ctgcggcact tcggcgcgga actcaccgcc
     4021 gacaaccggc tcgccctgca cgtcccccgc aacttcgcgc acgcgtacct gacactggcc
     4081 gacgacacgg agacggtgta ccaggtctcc gccgcctaca cccccggcgc ggaaaggggt
     4141 ctgcgctgga acgatccggc gctcggggtc gagtggccgg cgccggtgaa gctggtgtcg
     4201 gacaaggacg ccggctggcc gctgctgtcc gaggtgccgg cggggtcgcg atgatcatcg
     4261 tcgacaccgc gctgcgccgg cgcgaggagc gggaccggcc gatacgggtc ggcatggtgg
     4321 gcgccggttt catggggcgc ggactggcac gccacatcgt acggtcggtg cccggcatgc
     4381 ggctggcggc aatcgccaac cggagcctcg ccaccgccga gcgcgcgtac accgaggcgg
     4441 gcgtgcggcc ggtgcgggcg aacggcgcgg gcgatgtcga ggccgccgtg gccgccggac
     4501 gtcccgtggt caccgaggac gccttcgcgc tgctcgccgc cgaggggatc gactgcctgg
     4561 tcgacgtcac cggcgcggtg gagttcggtg ccagggtcac cgtggccgcc ctggagcggg
     4621 ggctgcccgt ggtgacgatg aacgcggaac tggacggcac cgtcggcccg ctgctcgccc
     4681 accgggcccg tgcggcgggg gtcgtgctca ccgctgcgga cggcgaccag cccggcgtgc
     4741 agggcaacct gctgcgcttc gtgcgcggtc tgggagtcac cccgctggtc gccggcaacg
     4801 tcaagggcct ccaggacgag taccgcaccc ccgccacgca gaaggcgttc gccgaacgct
     4861 ggggccagaa cgtgcacatg gtcacgagtt tcgccgacgg cacgaaggtc tccttcgagc
     4921 aggccatcgt cgccaacgcc cacggcctga ccgtggcgcg gcggggcatg tacggacgcg
     4981 ggcacaccgg ccacgtcgac gagctcaccg gcgtctacga catcgacgag ctgcgtgaac
     5041 tgggcggtgt cgtcgactac gtggtgggcg ccaggcccgg gcccggcgtg tatgtgatcg
     5101 gcacccatga cgacccccgg cagcggcact acctggagct gtacaagctc gggaagggcc
     5161 cgctctacag tttctacacg ccctatcacc tgtgccactt cgaggtcccg cacaccatcg
     5221 cgcgcgcggt cgacttcgcc gacgccgcgc tgacgccgcc ggccggcccg cgggtcgacg
     5281 tggtggccac cgccaagcgc gacctgaagg ccggcacggt cgtggacggc atcggcggct
     5341 acgacaccta cggcgtcgcc gagacccacg cggcgaccct ggcgtcccgg ctgctgccca
     5401 tgggggtcgc cgagggctgc gtgctgcgcc gggacatcgc ccgggacgcg gtgctcacct
     5461 atgacgacgt acggctgccg gcgggccggc tggtcgaccg gctgcgcgag gagcagaacg
     5521 agctgttccc gggctgacgg accggttccc cggctgctcc cacaccttcc agggcgcgtc
     5581 gccggccgcc cacagctcgt tgaggtgctg gtagtccttg aaggtgtcca tcgcgcacca
     5641 gaagtcgtgg tgggggtgca gggtgagctg ccggtcgcgg gccaggcgct ggagcggggc
     5701 gctctccagc cacagcttcg ggtcgtcgtc gaggtagtcg tcgaggaatt cgcggcggaa
     5761 catgaagaac ccgccggaga cgaaaccggt cacccgggtc ggcttctcgt tgaactccag
     5821 cacctggtcg tcctcgacgt ccatctcgcc gaacttcgac gtcgggtgga taccggtgac
     5881 ggtgccgatc cggccggcag cgcggtgctc cttctccagc gccgccaggt cgatgttccc
     5941 gaccccgtcg ccgtagccca tcatgaagtc gtcggtgtcc acgtagcgcc gcacgcggcg
     6001 cagccgagcg ccggtcgccg tgtccaggcc ggtctcggcg aacgtgatct cacagttctc
     6061 gtcggcccgg tcgtcgtgga agcggatccg gtgctcgtca ctgagggaga tggtgaagtc
     6121 cgagagctgg gcacggtagt cgaggaagaa ctgcttgatg gcccagccct tgtagccgag
     6181 gcacagcacg aaccggcgga agccgtagtg gctgtagatc ttcatgatgt gccacaggat
     6241 gggccggccc ccgatgtcca ccatggcctt gggcagccgt tcgctcgcct ccctgatccg
     6301 ggtgccgtag cccccgcaca ggagcaccac cggaatgtcc gagtccactg tcatccctcc
     6361 tcagccgtgg ccgtgcgatg gtccccgtcc cgccggacgc gcgcggggcg cacccgcagg
     6421 tccccgtcga gcgagccctc ccgccggcgg cgttcgagga cggcgagccg ggtgaagtcg
     6481 tgctcgaagg cggcgcgggt caggccccga gcgcggtact ccctcgccag ctgggccgcg
     6541 ccgtcgggga tcgtccaggt ggcccggtgg cccagttcgg tgcgggccct ggtgaagtcg
     6601 acccggtagg agcgcgggtc gttgccggtc tcgccgctga tctccaccac cgagccgggc
     6661 accgccgcag cggcggcctc ggcgatctcg gccacggtcc ggttgttctc ctcggtgccg
     6721 atgttgaacg cccgcgcccg caccgtggcg gcgggtgcgg ccagtccggc cagcaccgcc
     6781 cgcgcgatgt cctcggcgtg caccaggggc cgccacgcgg tgccgtcgga cagcacggtg
     6841 acccggccgc ccagcaccgc ccgccccacc aggttgttga gcacgatgtc ggagcgcagc
     6901 cgcggcgaga agccgaaggc ggtggcgttg cgcaggaaga acggcgcgaa gccggagtcg
     6961 gccagctcca cgaggtcgtc ctcgacccgc accttggaca cggcgtaggg ggtgaccggc
     7021 ttgagggggg cgtcctcgtc gaccggtgcg tcgccgctct gcgccccgta caccgagcag
     7081 gtcgaggcgt aggcgaaccg ggtgacgccg gcctccttcg ccagccgggc gaggcgggtg
     7141 gaggcgtggt ggttgacggc gtgggtgagc tcagggtcca gcgagcccag ggggtcgttg
     7201 gagagggcgg ccaggtgcac gacggcgtca tagccgcgga gggtgtccac ggtgacgtca
     7261 cgcaggtcca gggcgaggcc ggggacgtcc gggacgtcca gggcgccgag tacccgggag
     7321 gcgaacaggc cgctgtccag gccggtgacc tggtggcccg cggcggtcag cacgggggcc
     7381 atcacggtgc cgaggtagcc ctgatggccg gtgagcagga tgcgcacgga gcttggctcc
     7441 cttgtgtcgg tcgcgtacgg ctgtctcggc cgtgcgcggc tgtccgggtc gggtacggct
     7501 gtctcggccg cgtacggctg ctcagccgag gacggcgcgc cagcgcgggt cggtgacgtc
     7561 gacgccggac gaggcgagct tgccgcgcag gtcgtcccgc agccggccca gggtggtgcc
     7621 ggactgccgc aggttggcgg cgagccgggt gccgcgggcg cggtaggcgg ggggcgcgtc
     7681 ggggcgggcg gtgaagttct ccagcagcag cgcgtcgatg tgcgccgacc acggcagctc
     7741 gtggatgccg gcggcgatct cgctgggccg cagccggtgc cagtaggaga tgcccccggc
     7801 gtgcaccatc tgcgcggaga agaccttggt gccggggaag ctgtggaagt gggcgatccg
     7861 ccagcccgcg gccagggcca tgagctggta gaacatcagc ccgtcgaaga cgacccggat
     7921 gacgccgttg ccgttctggg cgtggtggtg gcgctcgtgg ctgcggacct cgcgcccgtc
     7981 gtcgagcacg tccagcaggc cgccctgcgg aaagggcagg cgcgggccct ccatggccag
     8041 caccttggcg agcgccgcct cgtggtgcgg ctcgatcagg cgcaccatgg cgccgtcgat
     8101 ctccttctcg gggccgggcg gtgtgtagga gtacgccgcc ggcgagacgg ggccgccgat
     8161 ggcgcgctcg atctcggggc gggccagcgg gttgatcgcc atgaacggcg gcgcggccag
     8221 cgggatcggg ccgtagctga gcgggctgct gacggcgacg tccggttcca gatcgtcggt
     8281 gcaccgagtg aaccagtcgg cgtccatgac gaagcagtcg ctgtcgacga tgccgaacgg
     8341 ccggtcgagg ttgcgcagca ggaactcgaa gatctcgtgg ctgccgaccc gttcgtccag
     8401 gtcgaaggcg ggccggccgc cggacatggt gtcgcgcagg cggatctcgt cgtcggtgag
     8461 cccgctgcac acgaaggcga tgttgagccg gggcggcacg aaacgcagga agtgctggat
     8521 gacgtgcatc agtccggagg agaagaaaca gaaccacacc ggtgtgtcgg cgggaagtcc
     8581 ggccaggaac gtacggaacc gctcgtcctg ggacagcagg gcctcctcgt aggaggggtc
     8641 cgctgcgcgg gccggagcgg gatgcgcgct ggtctgcata caggcctcat gacgtcgaac
     8701 tggtggtgga cggcacgttc accgctgccc ccgcccgggc cgcgcgggcc ggggtccggc
     8761 gctcgcgcgg cccgggcggc cgggcggtgt ccgcggcggg gtcagaggac gtcccagtac
     8821 tccccgagca ggaacggcat cccgaaggag accgacttct tgtcgttggg gcggtacttg
     8881 tcgcggggga tggtgcggaa gtccatgctg acccggctga tgtcggtgtc gttgacgacg
     8941 ttcccgtgcc aggtgttggc gccgtcgaag acgatcacgt cgccgtactc ggcgcgcacg
     9001 ggttccttgt cgatccacac cgtgttgttg ccgtaggcgc gggtgagcgg cacccagtag
     9061 ttgacctcgt tggggtcgtg cccgaagtcg ctgtcgcggt gccagtcgcc gacggcgacg
     9121 gcgagggagt tgcgcaggtg cacccggaag gtgggcacgc gctggatgta gtggtgttcc
     9181 gcgtccgcgc cgagcagggt gcgggccagc tcgcggtagg ccggctcgac ggcgtcgaag
     9241 gcctcgtaga accgcttgtg gtagtcggtg ctctggtcgg tctcccgggt cgcgacccgg
     9301 tcactcgccg cgaggccctc caggtcgtcc accgccagca ccttgcgcac cagatccccg
     9361 agcgggatct tcccgacgtc gtagtgcagc cgtgtgaatg ccgccatgtc ccctcctcag
     9421 atccgcatcc ggccgcgcag ccgggtgcac cgccggtacc agccgtccac cagttcgtcg
     9481 gtcgcggggt cgccggactc cccgtcgctc tcctcgaacc cccggcccgc cgcgcgcagg
     9541 gccaggcgtc gtgccgcgat gcgcagcggg accgccggca cggtcagctc ctccaggacg
     9601 ctgcccaccc gctccagcgg gccgaggtcg aagaactgcc gctgccagcg cagttcgttg
     9661 taccgccagt ccttcaggcc gttgaagccg cggcccgcgt tgtggtgcat gacgtcctgg
     9721 aggtcctgca ccatgacgcg cttcccggcg gcgcgcacca gggaggcgag gatgacgccg
     9781 agcccctcga aaccgcggta gcggcccgcc gggaagcgca cgttctcgat gacccagcgg
     9841 ttgacgcaca ggatgacgtc gtccacggcg tgcacctcgt gcaggcccga gccgtagtcg
     9901 tgcaccttgt cgtagtcggt gacgcggccg cgcctggtcg ccttctcgtt ccaccaggcc
     9961 agggagacgg tgtccgagcc gccgagggag ccgagcatgc cgacggagtc gtcctcgaag
    10021 accggtgcgg cgacgtcggc ggggttcttg cgcacgtcga cgtcgtcgag gagcatcacc
    10081 aggccggtga cctccgagtt ggcggcggcc tggtcgaaca tggcgttgta cgcctcgaac
    10141 agggagcgct ggttgcgcat ggtgaacaac gggctgcccg gtgtccggac gcgctcgatt
    10201 cccggacggc agatgcggtc gaacaggtcg gacgggccga cgcagactcc gtatccgatc
    10261 acgttggggc gaacctcctg tcgcggtcgg gggggtgagt ggcctgcggc cgaagggggc
    10321 cgccgcaggc ccggaccgga cgtcagaacc ggtaggtctc cagggagccg gtccgccgga
    10381 cgtccagcgt ggcgcagtgg aagccgccgc cgagggtgcg cgagtgcgtg agctggagcg
    10441 gcagcacgtc gacgccgtgc ttctccagca ccttgatcag gccggtctga cggcggtcga
    10501 cgaccgcgag gtcggggcgg accaccagca ggttcatgcc gatccacacc gagcagtgcg
    10561 gcttgtcccc ggtgaagccg atgtccacca gctccgggca gacgacggtc tgccaggagc
    10621 gcaggaagtc cggcatgttg tcgtcgttga cgcgcgccgg gttgacgagg accaggcccg
    10681 ggcgcagcgg cacgatcgtg gagtcgacgt gcgtggaggc gtacaggccg cggcaggggt
    10741 ggaccttgta ggtgctgccg agcgccgact ggagccattt cgcgcccagt tcgttgccgc
    10801 tgtcggagac caggtagagc aggtcggtgc cgaaccggag cacgttggcg gcgtcgaaca
    10861 ccggctccag gtcggtcagc cgctgtcccg cgggcgcggt cggctcgtac atctcgtcgg
    10921 cgagccgcgg cttgggcgcg gagagccacc gggcaccgct ggcgaagtac tccagcagga
    10981 tgtccttgta ggcgagggac tcgaggaaac gggcgcgcag cgccatcggt gactcgatga
    11041 cggtctggcc gactgcgagc agtccgtcgc gcgggcagta gtcgtggaag ccgtcggtct
    11101 gccagtcggg ggtggcgacc agggccgagt tgtcacgctg cccgggccgc cggacggtga
    11161 cgccgagctt ggtgagctcc tcgctcagga cgtgcagttc ctcctcggtc tccttgagca
    11221 cccggtccgg gtacgggccg gcgggaacct ggtcctggct gtcgtactcg tccgcgtact
    11281 ccacggcgaa cacgctgcgg tcggcccggg ggacccgggc accgaccgcc gttccgacga
    11341 tgatctcctc cagcgggtcc cattcgttgt gcacactgac caggctcatg gccctcctca
    11401 actgctgtcg gcaggaattg gtgctgcgac ggacgcttca gcgggtgttt cagcgcgaat
    11461 tcgacatgtg ttcggcggac gttccgggga gtgctcgcgg gcttgccccg gccttgtcga
    11521 aaagaagccg tgcgcggcag cggcgaaccc cgcggcgaaa tcacgccgcc gctgcccgcc
    11581 tcgctgtcgc ctcgccctgg aattgcaggc cgagtgagcc gccaatgggc cgcgagcata
    11641 gcgaagccgg ggcgcggtcg gcgaacacgg ccgccgttcg actgaagaat gtcggcactc
    11701 gaacagggga cttcccccgg ataaaccgaa tcggcggtgc cggggcaccg ccgattcctt
    11761 tgccgtcgtc ccggcccggc cggggtcagt ggccccgcag cgcctgtgcg agcgtgacgg
    11821 cggcggggtc gagggcggca ctgccgtcct cgatgtccca cagggcgttc tgcagcagcc
    11881 tgccgtacgt ccagccggcc gcccgtgccc ggtccaggcc gaggacctcg gtcagcaggt
    11941 cgaagcggcg tcgcacgacg cgtacgacgt cccgctgtgc gacgatgtcg tcccaccggc
    12001 tgtccagggc gggccacagg tcgaagccgg ggtcaccggc gagcggttcg gggtcgatgg
    12061 cgagccaggg ttcgcgctcg gcggcgagga cgttgccgta gtgcaggtcc cagtgcagca
    12121 tccggtcgcc gggttcgccg accagttcgg ccaccgccga cgcccagtcg ttcagcagcc
    12181 gccggtcggc cgggtcggcc agcgccgcga ccgcccgcgg cacctcctcc agcatggcgc
    12241 cggcgatgtc gccgaggccg cgcagccccc gcggcgcggg gacggacacc agccgggcca
    12301 gcagcccggc gagtacgccc atggcggcgt cgtcgtcctc gaccgaggcc agcgtgcggg
    12361 acgcgtccag ccgctccagg agcatggtgc tgctgcgcgg gtcgtggtcg agcagccgca
    12421 cgacgccgtg cccgttccag gtgcgcagtc cggtgatggc ggcggaggtc tcctccctgg
    12481 gcagctggag cttgaggacg gcgcgggtgc cgtcggtgcg cagcaccggc agcacgaggg
    12541 aggcctcgcc cgacgcggag gcgccgtccg ccgtcagctc ccagcggtcc agtaattcct
    12601 cgaccagcgc gggcagggcg gcgatccatg cctgtccctc ctcgccgaag gcgcgggcgt
    12661 acgacgccgc caggggttcc gggatctcca ccagttttga cgtgctcata tcgaattcct
    12721 cgggagggag cgggtgtttc tcccgcaacc tatcggagat cggtacaggc tcccgccgtc
    12781 cgtggacggt ggtggggccg aggaccgcgg gatacggtcg ccgccgtcca ccggccgtac
    12841 tctccgaagg agttgatcga tgacggcagt cattcccggg accggacgcg cggcgcggcg
    12901 gtccgcgcgg cgctggggcg gtgtcgccgc ggcgctggtg acggcgctga ccgtgacctc
    12961 cgccgccccc gcaccccgca tcggcgtgac cggcaccgaa ccggcccgcc cgcgcaacgt
    13021 catcctcctc gtcggtgacg gcatgggcga ctcggagatc accgcggcgc gcaactacac
    13081 cgtcggcgcc ggcgggcggc tcgccatgga ccggctgccg atgaccggtt cctccctcac
    13141 ctacgccgtg gacgagcggg gccgccccga ctacgtcacc gactccgcgg ccggcgccac
    13201 cgcctgggcc accgggcaca agacggtcaa cgggcgggtc gccaagaccc ccggcaccga
    13261 ccggccgttg cccacgctgc tggagctggc ccggcgtcag ggctacgcca ccggcagcgt
    13321 caccaccgca cgcctcaccg acgcgacgcc cgccgcgctc accgcccacg tcaccgaccg
    13381 gtcctgcgcg ggcccggcag acatggcggc ctgcccggcg gacgccaagg agcgcggggg
    13441 cgcgggctcc atcgcggaac agaccgtggc gctgcgcccg gacgtgctgc tcggcggcgg
    13501 cgcggacgtg ttcgggcagc ggatcacggc cggcccgcac cgggggcgga ccgtcctgga
    13561 gcgggcccgg gccgagggct accaggtggt gcgggaccgt accggtctgc gggccgcccg
    13621 cccggaccgc ccggtcctcg ggctgttcgc cgacgggccg ctgccggtcg agtggaccgg
    13681 ggtcccggcc cggcccggcg gcaccgcccc ccagcgctgc ggcaccggtg ctcccgcgca
    13741 cccggccggc acgccgagcc tggaggagtc gacgcgggcc gcgctggaac tgctgacggc
    13801 ccgtgcccgg cgggccggcg ccgccgccgg ggggttcttc ctgcaggtgg agggagccgc
    13861 catcgacgac cgggctcacg acgccgaccc gtgcggccag atcggggaga ccgtcgcctt
    13921 cgaccgtgcc gtcgggcagc gctggcctat gcgcacccat cccggcacgc tcgtcgtcgt
    13981 gacggaccac ggcagcggcg ggcagatcct gccgctggag gcccggccgc cgggccggtc
    14041 cgcgacgctc gtcaccgacg agggagcgcc cctgcatctc ggctacgcca gcggcgcgcc
    14101 ggacgacgtg caggagcaca ccggggtgcc ggtccgggtc gccgcccgcg ggccgtacgc
    14161 ggagcgggtc gtcggcgtgc acgagaacac cgcgctgttc cacaccgtgc gcaccgcgct
    14221 cggcctgcgc tccattcact agttgcttcc gacccggccg aattcacttt caagtgcctg
    14281 cggttgaaga atttccccgc ccccatcagc atggtccggc ggaaacagga atacgcagtc
    14341 accgcagatg ccgccacaca attgaaggat gtgacctttg agctcctccg tggaattacc
    14401 gaggtggccc cagctctccg acgacgatgt cgaggcggcc gtcgccgcat tgcgcgccaa
    14461 ccgcctggtg gggctgggca atccggtcgt cgagcaattc gaatcggccc tcgccgagag
    14521 ccaggccgtc gagcacgcgg tcgccgtgtc caccggcact gcggcggtcc acctcgccct
    14581 gcacgccctc gatgtcggtc cgggtgacga ggtgatcgtc cccgcccaca ccttcatcgg
    14641 ctcggcgagc cccatcgcct acctcggggc ccgcccggtc ttcgccgacg tcacccccga
    14701 cacccactgc ctggaccccg actcggtgaa gtccctgatc accgagcgga ccaaggcgat
    14761 cgtcgtcgtc cacatcaacg gcgtggccgc ggacatggcg tcgctgtccg cgatcgccac
    14821 ggacgccggc gtcccgctcg tcgaggacat ggctcaggcg ctgggcacca gcatcggcgg
    14881 ccgtccggtg ggcggcttcg gtgacctggc gtgcgtcagc ctgttcgagc agaaggtgat
    14941 cacctccggc ggcgagggcg gtgccgtcct gacgaacaac cccggctacg ccgagcgcgt
    15001 ccgccggctg cgcagccacg gcgagggtcc catcgccgac cgtcccggcc tgatctgggc
    15061 gtacgaggtc ggctacaact accggctgac cgcggtgcag gcggcggtcg gcctcagcca
    15121 gcacgggcgg ctgggcgaga tggtggaggc acgccggcgc aacgccgcgt acctgtccga
    15181 gcggctggcc gacgtcgagg gcctggagct gccggtcgaa ccggagggca ccgtgcacgc
    15241 cttctggaag tacgtggtgc gggcggtgcc ggccggtggc cggccgacgg ccgccgagat
    15301 cgccgcgacc ctgcgctcgc gcggtgtccc ggtcctgctg cgctatccgt tcccgctgca
    15361 caagcagccc gccttcgccg agcaccagtc ggtgtcgctg ccggtcgcgg agcggctgtc
    15421 gcaggagctg ctggcgcttc cgtcgcaccc cgcgctcacc gaacggcacc tcgatcacgt
    15481 ggcggccgag gtccgcaagg cgttcaccgg gtgaggtgac acctgggcgc cgcgccgcca
    15541 ctcctgccgg ggccgacctc ggcgggccgc cggacgcgcg gcgcccccgt gaccctgcga
    15601 gcgctccgta cggctcgcgt ccgcgacggg gcggggtcct gccgggcggc cgggcgggcc
    15661 gcaccgggcg taccgcttca ggcgggccgc accggtccgc acgggtgtcc gcccccgccg
    15721 cccgccccgt cgcggcgcgg cccccaccgg cacatgacgc gtcgtccgtc accggccggc
    15781 gccggcgttc cggcaggatc ccgccccgct cccccgaacg cccgtgcgcc cagcggtccg
    15841 tgcgacgcgg tgccgcgacc gcccccgcga cctcagctca ggagaatctg gagagcacat
    15901 gtcctctgtt ccactgcccg tctcctccga cgcctcgtcc cagcccgacg gggctccgcc
    15961 cctgctgctc ggcacgtccg cgttcgggca ggacgagcgc ggcttccccg tgtacgacgc
    16021 ctactgggag ggcggcggcc gggccttcga cacggcgtgg ctctacgggc acgcgtacgg
    16081 acccggctgc tgtgagcgca ccttcggcgc ctgggcgagg tcccggggcg tcgagaagga
    16141 ggtgtgggtg ctggcgaagg gcgcgcacac cccggagtgc ctgccggacc gggtggaggc
    16201 gcagctcgcc gagagcttcg accgcatggg tcgcgatgac gcagccatgt acatgctcca
    16261 ccgggacaat cccgacgtgc cggtcggaga gttcgtgagc gtgctggcgg acctggtggc
    16321 acgcggcctc atcggcgcct acggcatgtc gaactggtca ctcgaccggg tgcgggaggc
    16381 cgtcggctac gcccgggagc aggggttgcc ggcaccggcc ggggtgagca accaactgag
    16441 cctcatcgac atggtgcagc ccatctatcc gggcacgatg ggctcccacg acccgcgctg
    16501 gcgggcgtgg ctcaccgaga acccggtcac gctgtacccc tgggcgagcc agggtcgcgg
    16561 ggcccacgcc ctggcggacc cggccgagtt gcggacgagt ccgctcgccg agtgctggta
    16621 cagcgagacc aacgtcgagc gtctgcgacg ggcgcgcacc ctcgccgagc gcaggggtgt
    16681 ctcgtcgacc ggcatcgcgc tggcctggac gctgtcccag cccttccgcg tggtcgcgct
    16741 gatcggtccg cggcagccgg aggaggtccg cgattcgctg gccgcggcgg agctgcggct
    16801 gaccgaggcg gagcgggact ggctggagaa cggtacggga gagccgcccc gggagtgacc
    16861 ggaggcggga cggcggccac gagccccggc gcgggacccg gcctcgccgt cgtcccgccc
    16921 cgtcgccgtc ccccactccc ccggtccctg ctgtcggtcc ggtccctgcc gtcgctccgt
    16981 tccctgcggc cggccgctca ccgtcctgtg ccgggcccct gccgcaccgc ggtcaccgtc
    17041 cggtgtcggc ctcgccccgc tctccggtca ccgtccggcg cggggcgtcc tgcgccccgg
    17101 ggcaccggcg ctcgcgggtc cgcgcaggac ggtgtcgcag cacgggtcgg cgggaggcac
    17161 ggggcggtcg ggcgcgtcgg ggacctggac ggtgacctcc cccgtccgcc gggactccag
    17221 tgcggccgcg cggcgtggca tgccggcggc ggactgcccg gcgccttcgg cctcctggcg
    17281 gcccggtgcg ccgccggtct cctgctccgc cccggatcca cgggcccgtt cgagctgctc
    17341 ggcgacgagc tgccaggtct gggaacagcc ccgggccagc tcggcgacgg ctcccacgcg
    17401 gtgcgccggg acgttccgca gcagtcgctc ccagtcctgc gggcgcacgg ccgccacggt
    17461 gagccaccgc agcagcgtcc tgccgtcctc ggtgagccgt acggaggggt cgcggctgag
    17521 gtggcgcagg atcagcgcgc gggagggccg ctcggcctcg gcttcgtcgt acggccgctc
    17581 cggcgtgtgg gccggctcgg ggttcgtgcc gggctcggtc cgcgcgcggc cccgttcggg
    17641 gaccggcccc tcaccccgct ggagccgttt gcgcacgtcc gatacggttc ccagcgagac
    17701 cccggcctgg gcggcgatct ggcgcagcgg ggccgagggg ttctcctgca tgagccgtcc
    17761 ggccagccgc cgtccctcgg cggggtcgac gggacgggcc ctcccgtccc tgccgatgcg
    17821 gacgttcgat tgaggaagtc cctcggtcga acgcgcccgg agtgccgcca cggtcttggc
    17881 cgagaggccg gtcgcggtcc cgatcgcgcg gtccgaccac atggggtggc tgcgcaggat
    17941 gcgcgcggcg gcgtccttgc ggtcctggag gccgagcggc aggccgtggg tgatgttggc
    18001 ttccacggcg aggacgaagg cctccttctc gtcgccctcg aagaaccgga ccgccagctc
    18061 gctctccccg cggagttcgg cggcccgcag gcggtgcatt ccgtcgacga cccgcatcgt
    18121 ggaggccatc acgatgatgg gcgggagttc cgcgccggat tccgcgaggg cgcggatgtg
    18181 ttccgggtcc tccccggcac ttcgcggcga gtcggacggc ctcagggatg caatgggaac
    18241 catgacgaca ccggataact tcgcgctgtt cccgttgagt tccgataccc cccgggagga
    18301 caggtcgtgc atgtcgaact gacgacggga actgagctcc attacacacc tttcggtcaa
    18361 aaaggcattt tcgctgaatg gcgcaacgtg caacgcacga cttcccccaa cttccttcaa
    18421 tgtacgatta tcacctgccg cctcgtcagt aaagcaactg taaatgaccg gaaaaggtgg
    18481 ggccgccggc gagtgcgggg cggtccagct gggcatccgg ggcgcccgag acgggccacg
    18541 gcggtccgtc cacggcggcc tgccggggga agagccgccg ggccgcccgc catgggtggg
    18601 ggacctacgg ctgtttccgg ccgccggacg gccacgaaac gagcgccgaa caaccgcgcc
    18661 ccttacaccc ccgggtcagg ccgggacaga gatcaggtca ctcaccacag tgtttccgcc
    18721 accgtcctgc ggccgtaccg ctcatgcgtc gccggcccgc ccgtggcccc acgtcacgtc
    18781 acgcagggag agaacatgaa ggcgctcgtc ctggccggcg gagccggacc ccgcttacgg
    18841 ccgataaccc acacgtccgc gaaacaactc gtgccggtcg ccaacaagcc ggtcctcttc
    18901 tacggcctgg aggccatcgc ggcggccggg ataaccgatg tcggcatcgt ggtcggcgac
    18961 accgtcgcgg agataacgga agccgtgggg gacggctcga aattcggtct cgacgtcacc
    19021 tacatcccgc agcggaaacc actcggcctc ggccacggcg tccgcatttc ccgcgattac
    19081 ctgggcgacg acgacttcgc catgtatctc ggcgacaatt tcgtggtggg cgggatcgac
    19141 cagcccatcc gtgcgttccg cacccaccgg ccggacgccc atctgctgct cacccgggtg
    19201 tccgaccccc gctccttcgg cgtggccgaa ctggacgagc gcggccgggt gcgtcacctg
    19261 gaggagaagc cgacccaccc cggcagcgac ctggcactgg tcggcgtgta cctgttctcc
    19321 cccgcgatcc acgaggccgt ccgggccatc gagccgtcct ggcggggcga gctggagatc
    19381 acccacgccg tgcagtggct gatcgacgag ggcaaggacg tgcggtccac cctgatcagc
    19441 ggctactgga aggacaccgg caacgtcacc gacatgctgg aggtgaaccg gctggtgctg
    19501 gagacggtcg agccgcggtg cgacggggac gtcgacgagg acagcgaact catcggacgc
    19561 gtccgggtcg acgagggcgc cgtcatccgc aactcccggg tgatcgggcc cgtcgtggtc
    19621 ggcagcggca cgacgatcac cgactcgtac gtggggccgt tcacctccat cgccgagggc
    19681 tgcctggtgg aggaccagcc gagctggagt tctccattcg tgctgcgcaa cgcctccatc
    19741 tccggagtgc ggcgcatcga ggcgtccctc atcgggcggc acgtccgggt gaccgcggcc
    19801 ccgccggtac cgcacgcgca ccgcctggtc ctcggcgacc acagcacggc ccagatctcc
    19861 tcctgacccc gatcgacacc gaccgaagac ggaaggcggc tcacccgcat ggccacacgt
    19921 ctgctcgtca ccggcggcgc cggattcatc ggctcgcact acgtccgcac cctcctcggt
    19981 ccggacgggc cgcccgacgc cgtcgtcacc gtgctcgacg ccctgagcta cgccggcaac
    20041 ctcgccaacc tcgacccggt ccgcgaccac cccccggtgc gcttcgtcca cggcgacatc
    20101 tgcgacgcgg acctggtccg ggtcatggcc ggccaggacc aggtcgtgca cctcgccgcc
    20161 gagtcgcacg tggaccgctc gctgctcgat gccgccgcgt tcgtgcggac caacgccggc
    20221 ggcacgcaga cactcctcga cgcggccctg cggcacggcg tggccccctt cgtgcaggtg
    20281 tccaccgacg aggtctacgg ctcgctggag acggggtcgt ggacggagga cgaggccgtg
    20341 cgccccaaca gcccctatgc cgcctccaag gcgtcgggcg acctgctcgc gctggccatg
    20401 cacgtcagcc acggcctgga cgtgcgcatc acccgctgct ccaacaacta cggcccctac
    20461 cagttcccgg agaagctcgt cccacggttc gtcaccctgc tgctggaggg ccgcaaggtg
    20521 ccgttgtacg gcgacgggct gcacgtacgg gactggctgc acgtggacga ccacgtgcgc
    20581 ggtatcgagg cggtgcgggc ccgcggccgg gccgggcgcg tctacaacat cggaggcggc
    20641 acctcgctgg ccaaccggga cctcgtggac ctgctgctga aggcgtgcgg cgccggctgg
    20701 gacagggtgg agcacgtccc cgaccgcaag ggccacgacc gccgctactc ggtcgacgcg
    20761 agccggatcc gccgcgagct gggacacgtc cccgcgacgg acctgagcac cggcctggcc
    20821 gccacggtgg cctggtaccg cgacaaccgc gcctggtggg agcccctgtg cgccggccgc
    20881 gccccgcaga ccgcgtgatc ccggacgcgt acgtccccgg gacgtaccgg ccgcggcacc
    20941 tgccggccgc gcacagcgcc gtccgccggc cggggcacgc gccggccgcg ccgcaggcac
    21001 cggaggtccg ccgtcatgcc cctacccgca gagcaccgga ggtccgccgt catgtccgta
    21061 cccctcggct ctcgttggct cgtcaccggc gcgtccggga tgctcgggcg cgaactcacc
    21121 gcgcgcctca gccgccgggg cgtcccggtg gtcccgctgg ttcgccgggc ggacctggac
    21181 gtcaccgacc ccgccgccgc gcgggcgctg ctggcccggc accggcccgc ggtgctcgtc
    21241 aactgcgcgg cctggacggc ggtcgacgcg gccgaggcgc acgaggcacg ggccctggcg
    21301 gtgaacggcg agggacccgg tcacctggcc cgcgcctgcc gggcgacggg cacccggatg
    21361 atccagctgt ccaccgacta cgtcttcgcc gggctcgccg accgcccgta ccgggaggac
    21421 gacccgcccg cgccgcgcac ggcctacggc aggacgaagc tcgccgggga gcgggcggtg
    21481 ctcgacaccc tcccggacgg tggctacgtg gtgcgcaccg cctggctgta cgggtccggc
    21541 ggcgcgaact tcgtctccac gatgatccgc ctggcggccg cggagggcac cgtgcccgtc
    21601 gtcgacgacc agcacggcgg accgacctgg accggtgatc tcgccgaccg gctcctcgcg
    21661 ctcggcgccg cggcgctgcg gggcaccgcg ccgcccggtg tctaccacgc cgtgaacgcg
    21721 gggagcacga cctggcacgc gctggcgcgg gagatcttcc ggcgggccgg ggccgatccc
    21781 ggccgggtcc ggccgatcgg cagcggggaa ctggcccggc cggccgcccg gcccccgtac
    21841 agcgtcctcg cccagggccg gtggcgggcc gccggtctcg ccccgctgcg cgactggcgc
    21901 gccgcgctcg ccgaggcgtt ccccgcgctg ctgcgcgcgt cggcgcgggg cggcacggtc
    21961 aggcggtgaa gcggcgccgc agttcccggt ggaagtccgc acaggtgtgg tagtcgggca
    22021 gcagtccccg cagggcggac tcctccaggc cgggggcccg gctgtccttg gcggacagca
    22081 cgggctcgat cccggggggc caggcgatgc ccagggccgg gtcgagcggg tggaccgcgt
    22141 gctcacgctc gggggcgtag ccctcggagg tgaggtagac gacggtggca tcgtcggtga
    22201 gggccatgaa ggcgtgtccc agtccggcct cgatgtacac gctgcgccgc gggtcgtcga
    22261 gacggaccgt ctcccaggcg ccgtaggcgg gcgagcccgc ccggatgtcc accacgacgt
    22321 cgagcacggc gccgcggagg caggtgacgt acttggcctg gcccggtggg acgtcggcga
    22381 agtgcacacc ccgcacgacc cctttgcggg agacggagcg gttcacctgg gcgacgcccg
    22441 ggacgtagcc gagcgtgtcg ctcaacgggc cgccgcggaa gagttcctgg aattcccccc
    22501 gctcgtcgcc gaaaacccgc gattccacca gccaggcacc ttcgataccg agcggacgca
    22561 cgcctgaact ccttttctgt ggacatccgg ttcagaaccg gtacgactcc agagttccgg
    22621 tccgccgcac atcgacggtg acccggtgga aaccgctgcc cagtgcccgg gcatgggtca
    22681 gctggagcgg cagcacgtcg attccgttgt tctccaggac gcgcatcaga tccgcctgcc
    22741 gccggtccac gatcaccagt ccgggccgga cgacgagaat gttcgacccg ccccaccccg
    22801 agctgtggac ggcgccgtcc ggcggacccg gatccaccag ttccgggcac acgatccgtt
    22861 tccacgtgcg caggaacggg ggaatgtgct cggcgtcgac ccgctccgga ttgaccagga
    22921 tcagacccgg gccgagcggg acgacggcga agtcgccgtg cggcgaaccg tggggtcccc
    22981 ggcaggggtg cacggtgtac ctctccccca gcgccgcctg cagccagcgc gcgcccagcg
    23041 cgttgccgct gtcggacacc agatagagca ggtcggtgcc gatccgcagc accgtgtccg
    23101 cgtcgaagac cggctccagt tcgcgcagcc gctccccggc cggcgccgtc gggtcgtaca
    23161 tgacgtcggt cagcaccggc ggcggcgccg agatccagcg gctgccgctg gtgaagtact
    23221 ccatcagcag catccggcag gcgggcgact gcagggacgg gagaccgggc accgccggcg
    23281 tctggatgac ggtctcgccg acggtcagca gtccgtcccg gggccggtag gcgagggcgg
    23341 tgtccgcgcc gcggtccggg ggcgcgggcg ggctcgcggg gtcctgcggc ggaaggcggc
    23401 ggaccgtcac gccgaggccc ctcagctcct cgcacaggcc gtcgagctcg tcctcggtct
    23461 cgcgcaccat ccggttctcg gagccgaccg ccgttccgac gacgatctcc tccagcgggt
    23521 cccattcggt gtacacgccg gccaggctca tggtgtccct cttcacctcg ctgtacgtct
    23581 ggggaagcag tcgcggcggg cacccgcgcc cgggtcagcc ggccgggagg tagcgcagca
    23641 gccgtcccca catggcgtgg tcgtcggcgt cgcccgtgtg cggcgcggcg aaccgggccg
    23701 tgtactcggc gatctcggcg agctgccagc gcagctcgta gaacctgagg aagagcccgc
    23761 gaccgtccgg cgcggtgccg aaggcccggg cgaccgcggc ccagtcccgt tccggagggg
    23821 cccacatggt gctgccccag tcgaggatgt ccacaccgtc cccgaacagg acgttggcgg
    23881 ggctggggtc gccgtgggtc agcgcgggcg gttcgccctc ccagcgcgcg gcgcactcgg
    23941 cggccacgcg tgccgcctcg cggcgcagct cggccacccg gtcccggcac ccggtgacga
    24001 gccgggtgag ccggctcccg taggggccca ggtggtccgt gtccccctcc agggccgtgc
    24061 gcagtgcctt ctccaggtcg ccttcgaagg ggaagccgaa gtcctccacg ggcacttcgg
    24121 cgggcagccc gccgggggtg gcgaagccgt gcacctccgt cagccgggcg acgagcaggt
    24181 cgagttgggc gggggtcggg gggacgcgcc gggcggtggc ccgctcgacg taggggaaga
    24241 ccacgacggg cagtccggac agatcgtgca ccacgccgcc gtcgcccgcc gcgagggggg
    24301 cgagcacgaa gtgcttcccg gcccggcgca gcagcagggc ggcttcgtag gcgccgggga
    24361 aatggccgtc gagatcacgg cggacgctga tccacagcgg gccgtaccga taggaccagc
    24421 tgtcctcacc gagggggaag aactccaggc ggtgcgttgt ctcgtcgatg ggaacgacat
    24481 cccggaattt ctccgcgaca agccggacca gattccggcg atccacgagc tcgttttcca
    24541 agagcatgcc aaaggctaac accgtgacgg ggttgccgga ggcgttcaac cacctttgtg
    24601 ggatgggttg ttgagggccc gatcgaaccg ttcggaaaga tatggtggcc cgatggaaaa
    24661 cgacagcgac gtgctcctcg cacaccggct cgtggatgtc gcggacgcac tttccctgcg
    24721 ctatttcggg cggacgcccg cgtcgcggca gaaggccgac ggcagcccgg tcagcgaggc
    24781 cgacctcgcg gtggaggagg ccctgctgga gatcctcgcc gtggaacggc ccggtgacgc
    24841 ggtgctcagc gaggagagcg gtacgaggtc ggcggcggca cgccgctgga tcatcgaccc
    24901 gatcgacggg acgatcccct tcctggcggg gcggcgcgac tggggcaccc atgtcgccct
    24961 ggaggtcggc ggggagctgc ggatcggtgt gctcagccgc ccgacggaag gcctccgctg
    25021 gtgggcccgg cagggtggcg gcgcctacgc ctcctccgcg ggcgggccgt gtcgacgggc
    25081 gcgccggctg cgcgtcgagc cgtcgcgtgt cccgctcggc cgggcccggg tgggcggctt
    25141 cctgttcgcg ggctcgccct tcgaagcggt gcgggagcgg gtgcggtggg tcgagtcctc
    25201 cgtgtgcctg gtcgccgatc tcctggaggg gcgcgtcgag gggatcgtcg acgagggggg
    25261 acacgtctgg gaccgggcgc cggcggccct gctggtgcgg gaggccggcg gccgggtgga
    25321 cgatctgcac ggcgggcacc ggctcgaccg gccgtggctc gtgtacgggg cggacggcct
    25381 cgccccccgc ctcgccgggc tggtgcgcag cgtggccggc tgacggggcg gcgcgagggc
    25441 gggaccggtg cggggatcc
//
