LOCUS       BGC0000691             41323 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Actinoplanes sp. SE50/110 complete acarbose (acb) gene cluster,
            strain SE50/110.
ACCESSION   BGC0000691
VERSION     BGC0000691
KEYWORDS    .
SOURCE      Actinoplanes sp. SE50/110
  ORGANISM  Actinoplanes sp. SE50/110
            Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
            Actinoplanes; unclassified Actinoplanes.
COMMENT     On or before Mar 6, 2006 this sequence version replaced AJ293724.1,
            Y18523.3.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:17:24
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(<1..1206)
                     /gene="asp.3.3"
     CDS             complement(<1..1206)
                     /codon_start=1
                     /db_xref="InterPro:IPR001633"
                     /db_xref="UniProtKB/TrEMBL:Q27GS9"
                     /gene="asp.3.3"
                     /product="hypothetical protein"
                     /protein_id="CAJ81017.1"
                     /transl_table=11
                     /translation="MIQRNRQVCDARNESVALISRVVAERAVEPLFQPIVDLDTRRLVG
                     AEALARGPAGSPLEFPDQLFEAAARVDLVPELDQLCAARAHEIAQAPGAVVPPLVFINK
                     EPAGADRPLSEDLRLRLASISTYRYVLEFTERALAAHPSALLEVAARAHRTGGALALDD
                     VGADRLSLAFLPLLEPEVVKLDMHLLRDPYCAHTIETTALVCGYAQRTGAMVIAEGIET
                     EQDLQVARALGAGWGQGWLFARPGPLSAVRDWPVDPSARLRAPRPELYVPGASPFDMAS
                     ARHRARTGDRHLLDGLTAHVLRQLPFAGPYGVVLGAYPDLATGHGWIPRLADAASTAAL
                     VGVSGPGPGLPAPSPIRTSITDGLSGVESEAALVIVDPHVTVALCTRRRHDDAIDFVLT
                     FDP"
     source          1..41323
                     /db_xref="taxon:134676"
                     /mol_type="genomic DNA"
                     /organism="Actinoplanes sp. SE50/110"
                     /strain="SE50/110"
     subregion       1..41323
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000691"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..41323
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="((DOIS or DHQ_synthase or ValA or salQ) or strH or
                     strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /subregion_numbers="1"
                     /tool="antismash"
     misc_feature    complement(850..852)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            1728..5039
                     /gene="acbZ"
     CDS             1728..5039
                     /codon_start=1
                     /db_xref="GOA:Q27GS8"
                     /db_xref="InterPro:IPR005323"
                     /db_xref="InterPro:IPR006047"
                     /db_xref="InterPro:IPR006048"
                     /db_xref="InterPro:IPR006589"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:Q27GS8"
                     /function="secreted alpha-amylase is involved in starch
                     degradation"
                     /gene="acbZ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297:Pullulanase, type I (Score: 446.5; E-value:
                     3.2e-135)"
                     /gene_kind="biosynthetic-additional"
                     /product="alpha-amylase AcbZ"
                     /protein_id="CAJ81018.1"
                     /transl_table=11
                     /translation="MKRRPLRTAGAPAGTAPRSPSRPEEGRVLVLSRHRDVMRRLSAVL
                     ALGLVVPLLLAPPWRASAAPAGAAEPSAAALAHWGADRPAPAEQFYFVLPDRFADGNPK
                     NDTGGLSGDRLSTGYDPTDKGFYHGGDIQGVIDKLDYIQGLGTTAIWLAPVFKNRPVQG
                     TGAAASAGYHGYWVTDFTQVDPHFGTNADLKRLVQLAHRRGLKIYLDIIVNHTADVIQN
                     EGGKSTYVDKADAPYRDSRGRPFEDHNYADGSRPFPKVNLQSFPYTPVFASPADATAKV
                     PAWLNDPTMYHNRGNSLFSGENSEYGDHTGLDDLWTERPEVVRGMTEIYADWIRDADID
                     GYRMDTVKHSNIEFWQQFNPAIQQAARRAGKPGFFMFGEVFSADQEVESRYVRQGGLAA
                     SLDFSFQSAARTFVSGDTPATALADLYRHDDLYTARDTGAGRMPTFLGNHDIGRIGSFI
                     TTGGADRTSYLRRDQLAHELMFLTRGQPVVYSGDEQGFTGPGGDKDARQDMFASRTPDY
                     LDDDLIGTDRTHASDNYDTGHPLYRTIAELGALRKANPALRDGVQITRYAAPGAGIFAF
                     SRVDPVRRQEYLVAVNNATTAQTATVGTATPGSTFTGVYRAGGTAATGSDGKLTVTVPA
                     LSAVVYRGGSPIAVPSARPTVRISAPAAGASVPSRADLVADVTGDPLATVTFAAQAGSG
                     PWTVIGTARQAPYQVHHDLTGLAGGVTVRYKAVVRDGRGRTASSTSSLRVGTPDTHVAP
                     ERMVVHYQRPAGDYGAWRLYAFGDIDASAQTTYPDGQPFAGQDEYGAFAWVRLKPGAKN
                     AGFVVVDGNGVKDVQQDRFVDPGRQPEIWLKAGDATVYPSRQDATGRPDPQPDPKTAVL
                     HYRRADGDYTGWGLHVWDGAAQPTEWTAPLAPSGRDAYGVTFRVPLADGATGVSYVLHA
                     GDTKDQPTDQRIDFAAGREVWLLDGVAERLLPVTRRTAAGAGIDVTTSRAGWASRDTVV
                     WNTGVGSTLQPVGGGTDGRVYELAYAPVGGITVVGGELAGAYRTLRLTAQRDGLTESQR
                     VRFPKLWRYGAFRVADADRHRLATALRGQVVITERDASGKLLAATGVGAAGDLTG"
     gene            complement(5104..5907)
                     /gene="acbY"
     CDS             complement(5104..5907)
                     /codon_start=1
                     /db_xref="InterPro:IPR010390"
                     /db_xref="UniProtKB/TrEMBL:Q27GS7"
                     /function="acarbose export"
                     /gene="acbY"
                     /product="ABC transporter permease protein AcbY"
                     /protein_id="CAJ81019.1"
                     /transl_table=11
                     /translation="MTVSTARRYLRLTAVLCGASLHRLTAYRMDFLIGAASFVIRIACQ
                     IALIGVIFQYVPALGGWTRQQALFLLGFSLLPRGLDRLFTDQLWILAWQLVRTGDFFRY
                     LIRPVNPFYALLSERFLYPDGFGELATGIAIVVTAAGTMDLHLTVAQWLLLLPLVLGGA
                     LIHTFLKAFLASLSFWMTSSLNVMVAVNQLSEFTAYPLNLYHPVLRGVLTWVLPFAFTA
                     YLPVRYLLTGDAGPLLWMLPVTTLTVLLGYGTFRLGLRRYEMPGS"
     gene            complement(5904..6707)
                     /gene="acbX"
     CDS             complement(5904..6707)
                     /codon_start=1
                     /db_xref="InterPro:IPR010390"
                     /db_xref="UniProtKB/TrEMBL:Q27GS6"
                     /function="acarbose export"
                     /gene="acbX"
                     /product="ABC transporter permease protein AcbX"
                     /protein_id="CAJ81020.1"
                     /transl_table=11
                     /translation="MIRAARRYAPFALAGLHAVTRYRSTIVLSALTAAAATSLQVFLWR
                     AVYAGGPAPAGLPFAQLTSYIVLAQVLGMLHTNRIDEMIAGEVYRGDIAVSLVRPANYA
                     LSCLAVNLPTAALSALLAGAPVLAGFAMFASLPAPPPANLLLFAVALLLSVILAFEINF
                     LVGLAAFVTTNTWGIRTIKNALVAFLAGQVVPLALFPDGVARLLRLLPFQGLIDSPLRL
                     LLGGYSGGSGAAAILGVQALWAVLLYGVLALAWNRSLRRVEVLGG"
     gene            complement(6704..7777)
                     /gene="acbW"
     CDS             complement(6704..7777)
                     /codon_start=1
                     /db_xref="GOA:Q27GS5"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="UniProtKB/TrEMBL:Q27GS5"
                     /function="acarbose export"
                     /gene="acbW"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.6; E-value:
                     3.1e-51)"
                     /gene_kind="transport"
                     /product="ABC transporter ATP-binding protein AcbW"
                     /protein_id="CAJ81021.1"
                     /transl_table=11
                     /translation="MPGYARHARPDGTTGMIVAEHLSKHFKRYRREPGLRGSLRTMFSA
                     RYDVVRAVDDISFEVPSGVKIAYIGANGAGKSTTIKLLTGIMRPTTGRVRVDGLDPHRQ
                     RTRVAGRIGVVFGQRSQLWWDLPVLDSFRILRHVYEVPQAVYDRNMRLFRDRLDLGALG
                     NTPVRQLSLGQRMRAEIAASLLHDPAVVFLDEPTIGLDLVLKQAVRDLINHIHAELGTT
                     VMLTSHDIGDITSICDQALVVDRGTIVHQGTMRDLLRSVDTRAVTFEYAAGSVSEAAAL
                     RIITEGLPEVDATPAESGRIRVEFPVDRWSARQVIAFLLDRFDLSDVLVPDADLETLLR
                     RIYAGSRPEPVTAGDGA"
     gene            8551..9912
                     /gene="acbV"
     CDS             8551..9912
                     /NRPS_PKS="Domain: Aminotran_3 (52-387). E-value: 1.7e-80.
                     Score: 262.4. Matches aSDomain:
                     nrpspksdomains_acbV_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GOA:Q27GS4"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:Q27GS4"
                     /experiment="RT-PCR, protein overexpression, enzyme tests"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbV"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 372.7;
                     E-value: 3.6e-113)"
                     /gene_kind="biosynthetic-additional"
                     /product="dTDP-4-keto-6-deoxy-glucose 4-aminotransferase
                     AcbV"
                     /protein_id="CAJ81022.1"
                     /transl_table=11
                     /translation="MTRDVFRAGSFRHRRRDPAAVPVSRQADLLARESRHLAPGASEEA
                     ALGRRVFVEGRGATLRDADGVEYLDFAAGTLTQSLGHCHPEVVARLTEQAGKLWNVHDF
                     ATADRAALCELLAELLPDHLTTLAFFSTGAEVVEAALRTVQAVAEPGRNRVGALRHGFH
                     GKTMGARMLVHWDVGDQSFAGNSVLGYAPYCYRCPLELSYPSCEVRCATLVRRHIAEKP
                     NVSALFFEPVLGAAGVIVPPPGYWEQIAAACRDNGVLLVADEVLTGGGRTGTFLASEAI
                     GVAPDLVTLAKGTASGFPFAVLAGRDEVLRHPRAGLAGSTASTYAGNPLGIAAAHATLS
                     VISRDRLIEQVRDLGAVLADRLAEMHDRHPHLGDVRGIGLLHGLEFVHDRQSRRPAPEI
                     ARRVYTTALDAGLRTAIGGHIIRLAPPFVIDETELLRGLDLLDRAITEAGRVTA"
     aSDomain        8707..9711
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_acbV_Aminotran_3.1"
                     /evalue="1.70E-80"
                     /label="acbV_Aminotran_3.1"
                     /locus_tag="acbV"
                     /protein_end="387"
                     /protein_start="52"
                     /score="262.4"
                     /tool="antismash"
                     /translation="VEGRGATLRDADGVEYLDFAAGTLTQSLGHCHPEVVARLTEQAGK
                     LWNVHDFATADRAALCELLAELLPDHLTTLAFFSTGAEVVEAALRTVQAVAEPGRNRVG
                     ALRHGFHGKTMGARMLVHWDVGDQSFAGNSVLGYAPYCYRCPLELSYPSCEVRCATLVR
                     RHIAEKPNVSALFFEPVLGAAGVIVPPPGYWEQIAAACRDNGVLLVADEVLTGGGRTGT
                     FLASEAIGVAPDLVTLAKGTASGFPFAVLAGRDEVLRHPRAGLAGSTASTYAGNPLGIA
                     AAHATLSVISRDRLIEQVRDLGAVLADRLAEMHDRHPHLGDVRGIGLLHGLEFV"
     gene            9909..11387
                     /gene="acbU"
     CDS             9909..11387
                     /codon_start=1
                     /db_xref="GOA:Q27GS3"
                     /db_xref="UniProtKB/TrEMBL:Q27GS3"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbU"
                     /product="putative kinase (1-epi-valienol-7-phosphate
                     1-kinase) AcbU"
                     /protein_id="CAJ81023.1"
                     /transl_table=11
                     /translation="MTPRPVSTIDVSLASLLRTADWPHEDLRGPGGVRILDEAILGPSR
                     LLIVAAERNPESRYFVAVLRHDPSREAVGDAAHDRAVVQAMRERLALPTAAGHLIVFDG
                     DPAPFRATRPFDPGWSTNALSLADLDGTLHIHKAYRLVSAATREPHLLRLMHRGGRTQR
                     WAGDYHYVEQPSGRRYPLGLLYAYAEGDSLDLPLRHSIRSMWPALLGGTEPAGAVTAAQ
                     RSIAGELPGVGRFLRDFHTELAQRLEPAPTFPVNAYLRETAERVAALGCRISADERYPR
                     PVREAVVAALTGELDQATTSAVRVPWPAGPSHGDLHLSHILRRQTPDGWRLCVIDLSTP
                     APDPADPLGAAQSPWQDLVALLRGLEIFTADEFVHQAALRLGADQDDTCRTVLLISAGQ
                     TPDTPGWTGSRLTALRRMHDAASVWAGQVRRMLLSGYADGGEAAEEHPAWRIFRLRRLL
                     HELDYAYAHDQHYHAAINLRHVLQTYRPPVTGES"
     gene            11392..13521
                     /gene="acbS"
     CDS             11392..13521
                     /codon_start=1
                     /db_xref="GOA:Q27GS2"
                     /db_xref="InterPro:IPR013534"
                     /db_xref="UniProtKB/TrEMBL:Q27GS2"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbS"
                     /product="glycosyltransferase AcbS"
                     /protein_id="CAJ81024.1"
                     /transl_table=11
                     /translation="MHIIETYFECGGFDHRFIQGGTSVYLWQLSRGLADLGHRVSIVTP
                     AHGRLDDLRRLHEVEDLPGTDEYELPLVLDPRVWGERFPAQMDIALRTTAHRIRLAGVD
                     LYFLSNELLDQLPDRFYPPYESKGVDLVFFKPLAYQVAAIRFIRSHFGDQRAIVHAHEP
                     FYHYLMPAAFAADPAKHVVSTVQSNMPINKSVYRAEVARLLGFLGAPNALPADDPAGSR
                     SPHTVAMSQYQQLTHLHYEYPPDHVRVYDLVAEHADRIDFLSPGHRDYYTCFADTPFAQ
                     LFATLPVSRTVRRNADKTFVGGCAVGDEWVTGELPPVDREKVLAGLGLDPDLPAFYHNA
                     RYAVNHKGQVELIRAVDRVLSGGVRASFIVRCLSDAGIADPLFHEVVARHPGRVNLEWH
                     RVPEDQLREYARAADFCLFPSKFEMDTFLIAQGEAMAAGAVPIATAQLGMAHFGHVADP
                     LTGPDAATATGFAVNRSFAEDDPLLVQGLTEQIRRAVTLWNEQPGQYRRLSANAVARAR
                     EFTWRRAAQAHEAAFAGVWAGRTPRLPVGDLLRFGWFDELPADAWTLHRDEIAEVALAH
                     GDADAYLRCRPDDLDALAALFERAWARADFPACARTVELAEEHRQERVPQWRARLAGRG
                     RIDRDGRLHYRPPSAERVELVLPDLAEPLRGTVTVTAMAPTGDTFTGQLPAGTRRADLL
                     LTLSDGRTVWDEVTA"
     gene            13518..14609
                     /gene="acbR"
     CDS             13518..14609
                     /codon_start=1
                     /db_xref="GOA:Q27GS1"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="UniProtKB/TrEMBL:Q27GS1"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbR"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 237.2; E-value:
                     3.9e-72)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative
                     1-epi-valienol-1,7-bisphosphate-1-adenylyltransferase AcbR"
                     /protein_id="CAJ81025.1"
                     /transl_table=11
                     /translation="MSTGVRAVLLAGGEGRRMGALGAGRLKPLVPFGGAARLIDFSLAN
                     ARDSGLDQVLLLSQYQERQLMDDLRRTWWQPGFRVHFGPYDRAYTDGIPVEYEPPTGPP
                     ERGTADALIRKAPYLFGPDVTEVLVQHADHVYRFDYRPMIAEHRASGAALTVSYQRIDR
                     RYVHLFGMVEFDDRNRLVSFVEKPAEPTSDLVFAAFCVFDAAVLHRYLELLDGTDWQHD
                     ISRDVIPAMLAAGEHIRGCPVPGYWADIGTVERYHEAHLSLVGTPPSLAVDAMPWTVAP
                     RTARALVTSADGVRHSVVPADLVNHGTVERSVLFPAARIGPGATVRDSVLLPGAVVPAG
                     AEIDGAVVLEDGTVQQVTTGARR"
     gene            14606..15193
                     /gene="acbP"
     CDS             14606..15193
                     /codon_start=1
                     /db_xref="GOA:Q27GS0"
                     /db_xref="InterPro:IPR000086"
                     /db_xref="InterPro:IPR015797"
                     /db_xref="UniProtKB/TrEMBL:Q27GS0"
                     /gene="acbP"
                     /product="putative NUDIX hydrolase AcbP"
                     /protein_id="CAJ81026.1"
                     /transl_table=11
                     /translation="MTGAVRAVRSREVYRNPWMSVREDDIVHADGSPGSYGVVTKPDYA
                     LIIPRDNGLLHLVEQYRYPVGGRFWEFPQGSWPADAAGGAADLLARTELAEETGLRAGR
                     LTPLGRIHVAYGYASQGCHVFLAEQLTAGRSQRERTESDMRQRAVDAAGWADLVGSGRI
                     TDAATLAAYTLLRMYDSGTRQPMPEGAESCTW"
     protocluster    14993..36147
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[24992:26147]"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ) or
                     strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      24993..26147
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ) or
                     strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     cand_cluster    14993..36147
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((DOIS or DHQ_synthase or ValA or salQ)
                     or strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     gene            15181..17385
                     /gene="acbI"
     CDS             15181..17385
                     /codon_start=1
                     /db_xref="GOA:Q27GR9"
                     /db_xref="InterPro:IPR013534"
                     /db_xref="UniProtKB/TrEMBL:Q27GR9"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbI"
                     /product="glycosyltransferase AcbI"
                     /protein_id="CAJ81027.1"
                     /transl_table=11
                     /translation="MHVVSFAFEALAFDVGMMRGGLAPLAWELARHYAAQGHRSSIVTP
                     AHGRLPYLAERYDLVELDYRDEHVVPVVPDPDVWAGQPRELGLPLVTRAHLLRHEGVDI
                     YLLSDEYLDLLPERLYPAGTSEGSDLAYFKPLVFQVGGLRFLQSRLAGDEPAVVQAYEP
                     YYHYLLPPVLAGDPRFRVMSTVASSMPIDLGVYRPQVDRLLEHFGAGTDLDRYVESPVA
                     AGADHPAATREAALGAAMAGYLPTTRLSSGRRRADYVGLFALITDHCDTVDFLTPGQRR
                     FYSTFRDTPYEAAFRRTAVARVVRENAAKQFVGGCALPENWLRRDPAEVDRAAYLSGLG
                     LDPALPTFYHVGRYSPHHKGQVELFRAVERILATDTRVNFVLRCATSAGGGGARIGDPA
                     FQAVADRHPGQVRLFWTMADEDELFTEAVAADFGLFPSKYELDTFLTAQGQLCACGAVP
                     IGTAQESTRHYRHQLATDHPLATGFALPRSFTPDDERLTGALVRTMREALRMYRDEPGE
                     YRRLAGNAAELARTFRYAEVSRRRLAHFAKLLDGTPTAADPEHVIGCGWFDQLDAAQWA
                     AHLPQIRREAIRLGDLETLRRCGPVDPGALGALYEAAYRRADFDRCVRVAELLGDRGSE
                     AVSLRRRCRVRPHEQGWEIQYRAPGAEQVALVVGGTAHRMHGSAGRFSTVLPTVPMPSP
                     VFLLTLASGRYAWDAPPATAHLADLAGQPHPAQPVGAGGR"
     gene            17387..18238
                     /gene="acbJ"
     CDS             17387..18238
                     /codon_start=1
                     /db_xref="GOA:Q27GR8"
                     /db_xref="InterPro:IPR000150"
                     /db_xref="InterPro:IPR006379"
                     /db_xref="InterPro:IPR013200"
                     /db_xref="UniProtKB/TrEMBL:Q27GR8"
                     /gene="acbJ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1179:hydrolase (Score: 208.3; E-value: 2.6e-63)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative hydrolase AcbJ"
                     /protein_id="CAJ81028.1"
                     /transl_table=11
                     /translation="MDGIGTTPPRDHRVVATDLDGTLLRSDLTVSARTRAALRDARAAG
                     MIHLAVTGRPVIDTRRLLAGLGYTGPAVCGQGAQVYDFGTDRLLLSRSLDTDLVRELVR
                     RIAQRTGPLALAAVSAGLGTEFLVTAGFGAPYQQHRWQLVDEPDLWRAPVAKVLIRHPD
                     HDDDTLAALADEVCGAALSVMHAGPGLVELLPGDTSKRTGLAFLAAELGFTGADTIAFG
                     DMPNDLPMFDWAGYGVAMANGHPRLRDRADEITVSNDADGVAVVLERLPAVRAGNRKAS
                     LR"
     gene            18235..20331
                     /gene="acbQ"
     CDS             18235..20331
                     /codon_start=1
                     /db_xref="GOA:Q27GR7"
                     /db_xref="InterPro:IPR003385"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:Q27GR7"
                     /function="acarbose degradation"
                     /gene="acbQ"
                     /product="putative acarbose 4-alpha-glucanotransferase
                     AcbQ"
                     /protein_id="CAJ81029.1"
                     /transl_table=11
                     /translation="MTTTTDAALIELAGRYGVSVDWTTDRGEPRTVPADTIQRILAVLG
                     VDASSGPAIAAALRAADDDARHRLLPSCVVVRQGEPARGVHPVAGAAYVVATEDGGRHE
                     TADPRNDLGRLPIGYHTLRVRVGDRSAAAPVIVAPAVLGTPDRRHWGMLAQIYSVLSER
                     SWGMGDLGDLADLTRWSARLGASFVLVNPMHAYVPDRLADPTPYRPGSRRFADPMYLRL
                     ADVAEYATAEPAVRAELDRAARQGHELTAEVLHRNALIDRARVWPVKRNALERLYRAPR
                     TAGRSAALAAFTAREGRGLEDYATWCALAEVYGTRWRSWPAALQSPHGPAVAAARRELV
                     DRIDFHRWLAWLVDEQMAAAQAAAVGSGMAIGVIHDLAVGVDPEGADAWAVQDHLAGGV
                     TVGCPADDFNPLGQDWGLPPWRPDTLAEAGYRPFADVIRGTLRHSGALRLDHILGLFRL
                     WWIPAGSGARDGAYVRYDHEAMLGVLAVEAFRAGAMIIGEDLGTVHPAVRAELADRGIL
                     GTSVLRFEYQGGSENRSGPLPADQWRAGCLATLTTHDLPSTAAWLSGEHVDLQDRLGLL
                     NRPRAEVAADAAAERDGWLAELRRTGLLEHETAVPGMSAESLALHRFLARTPARLVGVW
                     LPDLVGDRRPQNLPGTSTEFPNWQLPVADADGRPVAMDDLASSAGAQAVAGLYAASAEP
                     ATTP"
     gene            20363..21262
                     /gene="acbK"
     CDS             20363..21262
                     /codon_start=1
                     /db_xref="GOA:Q8RMD4"
                     /db_xref="InterPro:IPR002173"
                     /db_xref="InterPro:IPR011611"
                     /db_xref="UniProtKB/TrEMBL:Q8RMD4"
                     /experiment="RT-PCR, protein overexpression, enzyme tests,
                     protein purification"
                     /function="phosphorylation of acarbose (intracellular
                     inactivation)"
                     /gene="acbK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1276:PfkB domain protein (Score: 88.8; E-value:
                     6.7e-27)"
                     /gene_kind="biosynthetic-additional"
                     /product="acarbose 7-kinase AcbK"
                     /protein_id="CAD29481.2"
                     /transl_table=11
                     /translation="MSEHTDVLVLGGAGVDTIAYVPELPLPFQDSYVVAAIEPRAGQTG
                     DNVALGLHTLGLRTMHVDVLGDDPEGDLVRAFHTRHGLPFAALPTAAGTKRAVNLVGPD
                     GRRLSLWDGSREAEEDRYPAALIAAHTAHARHVHVCITPPGQHVFGQLNDLPVTVSTDL
                     HNWDGAYEGFEVYAFNADLVFLSATALTDVAATMRRVIDRGRARLVVATDGAHGGSVLV
                     RGETEVRRYAAVAPEAPVVDSNGAGDAFVSGFLFGHLAGEPLETCLRYGAIAGAYACTI
                     PATRAGAIDRAALLRPAA"
     gene            21259..22338
                     /gene="acbM"
     CDS             21259..22338
                     /codon_start=1
                     /db_xref="GOA:Q8RIS8"
                     /db_xref="UniProtKB/TrEMBL:Q8RIS8"
                     /experiment="RT-PCR, protein overexpression, enzyme tests,
                     protein purification"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbM"
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 67.7; E-value: 1.8e-20)"
                     /gene_kind="other"
                     /product="2-epi-5-epi-valiolone 7-kinase AcbM"
                     /protein_id="CAD29482.2"
                     /transl_table=11
                     /translation="MKRPPHHPVTVADVGGTHLRWARWSPDGGLGEVHTTPSPGHARRP
                     GAGAADLQAELIRELASRVEPGARAGVSLGAAMDHHSGTAYASAPLWGPQVSPFDVPAA
                     LRAARPDVHWTVVNDVTAGLLHLAEMVRDAGVRKACLVTISTGIACRTMDLRTGGIPVD
                     AAGLQGEIGHLPATVLADGVPVVTRCDCGEPGHVAASSSGPGIRRVAAVLARRDPATWA
                     GSGPTTRMMAGSGFEDAFRAALDDGDPVAADLLTAVTAPIADLLRTALCLDPELDLIAL
                     TGGVAHGLEPHYSAAVHDHLRRRGLYLTSEREPDWLTGRIRVVPPATADPLVGAGLAAL
                     AAGPVPAYSGGGREALVGR"
     gene            22335..23435
                     /gene="acbL"
     CDS             22335..23435
                     /codon_start=1
                     /db_xref="GOA:Q8RMD3"
                     /db_xref="InterPro:IPR002085"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013154"
                     /db_xref="UniProtKB/TrEMBL:Q8RMD3"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 92.1; E-value:
                     5.3e-28)"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclitol dehydrogenase AcbL"
                     /protein_id="CAD29483.2"
                     /sec_met_domain="ADH_N (E-value: 5.9e-12, bitscore: 36.4,
                     seeds: 66, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRHRAIVRTGTGVVVADVPTPVPGPGELLVGTEWAGLCGTDIQM
                     LRGLRDDPEPIIGHEGIARVIAAGDGVPGTLRPGTLVAVNPTHRDDPSFLLGHNVPGLL
                     QERTLLPATAVSGGLVLPLPDGTDVTLGPLLEPLAVVSYALSQLGAVRPATLVIVGDGT
                     VGHLAARAAVTWLAERPRVVLVHHTAAGRDFSAAGPHPADVLLTTGELAGRPLPGPVAA
                     LLATPRDATVEALEAVLAAAGADVLIDVLGGLPPGARSAMLPGVDLTAVRAANCGGFPE
                     PALVTTTSGGTRLFGHRGVGNAHLRAAAGELARDPDRYRDLVTHRSDLAGAARIMTALR
                     SGRDRIIDGRRLVKLAIQVNVREDHR"
     gene            23432..24187
                     /gene="acbN"
     CDS             23432..24187
                     /NRPS_PKS="Domain: PKS_KR (10-164). E-value: 7.4e-07.
                     Score: 21.1. Matches aSDomain:
                     nrpspksdomains_acbN_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:Q8RMD2"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="UniProtKB/TrEMBL:Q8RMD2"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     109.8; E-value: 2.7e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="cyclitol oxidoreductase AcbN"
                     /protein_id="CAD29484.1"
                     /transl_table=11
                     /translation="MSGTLVGRRALVVGGTTGIGRGIADAWAAAGAEVTVCGRSEPAGD
                     GAAGLHWEPLDLTRTGEAGARLERIAGDRVDLACFAAVSYGARRAVFEDVAVDEWRTQL
                     DINVHGLWLTLRAALPGLRAARPGLFVGVSSEVVYNAGPGRSGYTASKAAAKALLESVA
                     QEEDESRVRIVQVLPAGMVDTPSIRRRRPAGFDYSDYMVPADFARNALELAATAGAGHH
                     GDSLVVDRGGDWWSVRERMPVSQSRPVRT"
     CDS_motif       23462..23551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_acbN_0001"
                     /evalue="1.80E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="acbN"
                     /protein_end="40"
                     /protein_start="10"
                     /score="11.0"
                     /tool="antismash"
                     /translation="LVVGGTTGIGRGIADAWAAAGAEVTVCGRS"
     aSDomain        23462..23923
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_acbN_PKS_KR.1"
                     /evalue="7.40E-07"
                     /label="acbN_PKS_KR.1"
                     /locus_tag="acbN"
                     /protein_end="164"
                     /protein_start="10"
                     /score="21.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="LVVGGTTGIGRGIADAWAAAGAEVTVCGRSEPAGDGAAGLHWEPL
                     DLTRTGEAGARLERIAGDRVDLACFAAVSYGARRAVFEDVAVDEWRTQLDINVHGLWLT
                     LRAALPGLRAARPGLFVGVSSEVVYNAGPGRSGYTASKAAAKALLESVAQ"
     gene            24184..24996
                     /gene="acbO"
     CDS             24184..24996
                     /codon_start=1
                     /db_xref="InterPro:IPR012307"
                     /db_xref="InterPro:IPR013022"
                     /db_xref="UniProtKB/TrEMBL:Q8RMD1"
                     /experiment="RT-PCR, protein overexpression, enzyme tests"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbO"
                     /product="2-epi-5-epi-valiolone-7-phosphate 2-epimerase
                     AcbO"
                     /protein_id="CAD29485.2"
                     /transl_table=11
                     /translation="MTCRVGLTEWRLAPSGAAAIRLAAAVGADGIQLDFGGPGRGVLVD
                     GPGRAGQLRAVADEAGVDLLALAGNLLNDIGLTSQPAVVQPVLARLADTATELGVPLLI
                     VPSFRRSAITDAMSFTRTAAALRWAVSLAEARGIVLASENVLPPARARQLVEEVGSPAF
                     RLLLDTFNPVRYGLDPAWLATELRPWWADQIHLKDGPPDTGPSPLLGAGQGGVRRTLTA
                     LRGSPAPVRALVLENDYRDGHGARLRADLEWARRAAVNARESEKGKLT"
     gene            24993..26147
                     /gene="acbC"
     CDS             24993..26147
                     /codon_start=1
                     /db_xref="GOA:Q9ZAE9"
                     /db_xref="InterPro:IPR002658"
                     /db_xref="UniProtKB/Swiss-Prot:Q9ZAE9"
                     /experiment="RT-PCR, protein overexpression, enzyme tests"
                     /function="cyclisation of sedo-heptulose-7-phosphate"
                     /gene="acbC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: DHQ_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: ValA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 296.9; E-value:
                     3e-90)"
                     /gene_kind="biosynthetic"
                     /product="2-epi-5-epi-valiolone synthase AcbC"
                     /protein_id="CAA77208.2"
                     /sec_met_domain="ValA (E-value: 5.8e-194, bitscore: 634.5,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="salQ (E-value: 1.1e-195, bitscore: 640.7,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 4.4e-69, bitscore:
                     223.4, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGVETVGVHADAHRDSWQVRAQKQITYEVRFRDDVFGLDSTDLL
                     EAGADGAGSRRRFVVVDSAVDALYGSRIREYFTHHGIDHSILVMRVGETVKDFDTAGRI
                     VAAMDAFGLARRREPMIVVGGGVLMDVAGLVASLYRRGTPFLRVPTTLVGLIDAGVGAK
                     TGVNFNGHKNRLGTYAPADLTLLDRRFLATLDRRHLSNGLAEMLKIALIKDAELFQLLE
                     RHGRVLIEERFQGRTGTGDRAAVRALRAATHGMLEELGPNLWESRLERSVDYGHTFSPT
                     IEMRALPALLHGEAVCVDMALTTVLAYRRGLLDVAQRDRIFAVMTALGLPTWHPLLTPE
                     VLEAALQDTVRHRDGWQRLPLPVGIGGVTFVNDVTAGRAAGRPR"
     gene            complement(26253..27215)
                     /gene="acbB"
     CDS             complement(26253..27215)
                     /NRPS_PKS="Domain: NAD_binding_4 (4-184). E-value: 6.4e-16.
                     Score: 50.0. Matches aSDomain:
                     nrpspksdomains_acbB_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GOA:Q9ZAE8"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="UniProtKB/Swiss-Prot:Q9ZAE8"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     324.6; E-value: 1.2e-98)"
                     /gene_kind="biosynthetic-additional"
                     /product="dTDP-glucose 4,6-dehydratase AcbB"
                     /protein_id="CAA77209.2"
                     /sec_met_domain="NAD_binding_4 (E-value: 3.2e-16, bitscore:
                     50.0, seeds: 102, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.4e-17,
                     bitscore: 54.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.6e-18, bitscore:
                     56.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILVTGGAGFIGSHFVTSLISGDIATPQPVTQVTVVDKLGYGGN
                     LRNLAEASADPRFSFVRGDICDEGLIEGLMARHDTVAHFAAETHVDRSVVASGPFVASN
                     LVGTQVLLDAALRHHIGRFLHVSTDEVYGSIDTGSWAEGHPLAPNSPYAASKAGSDLLA
                     LAYHQTHGMDVVVTRCSNNYGPRQFPEKMIPLFVTRLLDGLDVPVYGDGRNIRDWLHVS
                     DHCRGLALALGAGRAGEVYHIGGGWEATNLELTEILLEACGAPASRISFVTDRKGHDRR
                     YSLDYSKIAGELGYRPRVDFTDGIAETVAWYRANRSWWT"
     aSDomain        complement(26664..27203)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_acbB_NAD_binding_4.1"
                     /evalue="6.40E-16"
                     /label="acbB_NAD_binding_4.1"
                     /locus_tag="acbB"
                     /protein_end="184"
                     /protein_start="4"
                     /score="50.0"
                     /tool="antismash"
                     /translation="VTGGAGFIGSHFVTSLISGDIATPQPVTQVTVVDKLGYGGNLRNL
                     AEASADPRFSFVRGDICDEGLIEGLMARHDTVAHFAAETHVDRSVVASGPFVASNLVGT
                     QVLLDAALRHHIGRFLHVSTDEVYGSIDTGSWAEGHPLAPNSPYAASKAGSDLLALAYH
                     QTHGMDVVVTRCSNNYG"
     gene            27298..28209
                     /gene="acbA"
     CDS             27298..28209
                     /codon_start=1
                     /db_xref="GOA:Q9ZAE7"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005907"
                     /db_xref="UniProtKB/Swiss-Prot:Q9ZAE7"
                     /function="involved in acarbose biosynthesis"
                     /gene="acbA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 267.5; E-value:
                     2.3e-81)"
                     /gene_kind="biosynthetic-additional"
                     /product="dTDP-glucose synthase AcbA"
                     /protein_id="CAA77210.2"
                     /transl_table=11
                     /translation="MRGILLAGGTGSRLRPVTWAVSKQLMPVYDKPMIYYPLATLVSCG
                     IREILVITTETEAAQFQRLLGDGSQWGLRLEFAVQQRPGGIAEAFLIGEEFLAGGPVAL
                     MLGDNLLHGVDFRPCVQRARETAGGHVFGVAVADPSAYGVVEFDAAGRVLSIEEKPVRP
                     RSPYAVPGFYLYDADVVETARSLRPSARGELEITEVNQAYLRRGALSVTLLGRGAVWLD
                     TGTLADCMRAVDYVRAIDEGQGIKIGCVEEAAWRAGFLDTAQLRALAEPLMSSGYGQYL
                     LALTGDGLSRTPQWPALTAAAG"
     gene            complement(28302..31418)
                     /gene="acbE"
     CDS             complement(28302..31418)
                     /EC_number="3.2.1.1"
                     /codon_start=1
                     /db_xref="GOA:Q27GR6"
                     /db_xref="InterPro:IPR005323"
                     /db_xref="InterPro:IPR006047"
                     /db_xref="InterPro:IPR006589"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:Q27GR6"
                     /experiment="RT-PCR, protein overexpression, enzyme tests"
                     /function="extracellular starch degradation"
                     /gene="acbE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297:Pullulanase, type I (Score: 764.3; E-value:
                     3.3e-231)"
                     /gene_kind="biosynthetic-additional"
                     /product="acarbose resistent alpha-amylase AcbE"
                     /protein_id="CAJ81030.1"
                     /sec_met_domain="Alpha-amylase (E-value: 3.2e-64, bitscore:
                     208.3, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDERLKSHIVRALLPVLVGAAGGLPAPRAAQAESPPDRPSHAEQL
                     YLVMPDRFANGDTGNDQGGLTGDRLTTGYDPTDAGFYHGGDIQGVIDKLDYIQGLGTTA
                     IWLTPIFKNKPVQGTGPNASAGYHGYWITDFTQVDPHFGTNEDLKRLVGLAHRRGMKIY
                     LDIVVNHTADVIKNAEGTAYADKGTAPYRDTAGRPFEDRNYADGTHGFPKVDEKSFPHR
                     PFFEKPSDATAKAPAWLNDPTMYHNRGETTFGGENAEYGDFTGGLDDLWTERPEVLHGL
                     TDIYAGWIRRFGVDGYRLDTLKATDLAFWRPFAEGVGKAADKAGKRDFFLFGEAWSKDQ
                     EVTSTFVRRGGLPATLDFPFQGAAQSYARGQGTGQQPWQDLYAKDDLYSRRPGPTPAGC
                     HLGEWNHDMGRIATLIKAGSDPKRGCRLELVNELMFLTRGQPGGLLRADEQGFTGRPRL
                     NKGSRQDMFASRTPDYLDDRLIGTDKTHASDNHDTGHPLYRTIAELGAVRKAHPGLRDG
                     EQITRYAADRAGVFAASRIDRDQRAEYVIAVNNATTAQTVTFDTYTPGCGFQPLYGTGE
                     TAATGADGRLTITVPALSAVAYRAEKPIPAADGAPAVTITAPAGRDPRAGPHRTDRAVT
                     GDPLSTVTFSARAGNGPWQPIGTAGRGPYRVFHDLTGLAGGAEVQYRRSPGTPRPYRHH
                     HQPDPVGTVRAEAGYAVVHYQRPAGDYDGWRLHATGERSKRPRSNPQGEPFTGNGTPNG
                     PFAWVKLRPGATKVTFTVSDANGVKDVDADRSLNPQQTPGIWLHQGDPAISYQGPAPAP
                     APNTAILHYRRPAGDYTGWGLHLWDGAATPTADWGAPLLPESFDSFGAVFRIPLAAGAT
                     GLSYIMHAGEAKDLPTDQRLEFADAGREVWVQAGVQERLLPSVVKPAKLDLTRADAVRV
                     DRDTIAWQTGTPDTLEPAGAATDGRVYDLVHAPNGGLRLVDGDLAGDYRSIRLTAQRDG
                     LTEKQRRQAPELWQYPAFQAAAALPSGDGQFYVTERDAQGRLMSVTGVR"
     gene            31744..33918
                     /gene="acbD"
     CDS             31744..33918
                     /EC_number="2.4.1.19"
                     /codon_start=1
                     /db_xref="GOA:Q27GR5"
                     /db_xref="InterPro:IPR002044"
                     /db_xref="InterPro:IPR002909"
                     /db_xref="InterPro:IPR006047"
                     /db_xref="InterPro:IPR006048"
                     /db_xref="InterPro:IPR006589"
                     /db_xref="InterPro:IPR013780"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR013783"
                     /db_xref="InterPro:IPR013784"
                     /db_xref="InterPro:IPR014756"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:Q27GR5"
                     /function="extracellular transfer of acarviose, involved in
                     acarbose metabolism"
                     /gene="acbD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1257:Alpha-glucosidase (Score: 186.7; E-value:
                     1.3e-56)"
                     /gene_kind="biosynthetic-additional"
                     /product="acarviose transferase (ATase) AcbD"
                     /protein_id="CAJ81031.1"
                     /sec_met_domain="Alpha-amylase (E-value: 7.3e-73, bitscore:
                     236.7, seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="Alpha-amylase_C (E-value: 4.9e-11,
                     bitscore: 33.8, seeds: 246, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQRHARHAIAAAVAVSLLPPSLPAHAAGASAVVPYAGNPASLKQD
                     LCYQIATDRFSDGNPANNNPGNVPGMFADKTKLNDRQEWLKYMGGDFAGITQRMEYLKN
                     LGVGAIWISPHVDNINVPANGATGYHGYWPRDFKRLEEHFGTDEEFDALVSAAHASNIK
                     VIMDWTPNGTNPPNQAEDGALYDDGQLVGRYGADSAGHFHHGPAIGDFNDRYQDQYYSL
                     ADIADLDQQNPRVDQLLKDDANYWMDRGVDGIRVDAVKHMPLSWQRSFADAVTSHKSAA
                     IFGEWYMGDQSDPLYADQVKFANTSGIAAMDFYTNRSIRDTFAGAGSMKSLDAAITKTN
                     RDYLYEQDLITFLDNQDTRRFGTLNSDPAALHRALAFLLTTRGTPCLFYGTEQYLHNDT
                     GEGSNKGKDPYNRPPMASFDTDTVAYREIRALSDLRRSNPAVAYGDHQQRWINDDVYVY
                     ERRFGDNVLLTAINKGSHEYRLDGLRTALPAGTYRDVLGGTFGGSDLTVEDGDGTDRST
                     VAPVLGAGQVAVWSYRAPVDTEPRIGGVGPVVTRAGATVTVEGTGFGSGGTVAIGGVPA
                     TVQQWTADRITATVPVGVPTGAVQVTVGNGSGTSNGYPITTRTGKPVPVQFTVQNPPAT
                     APGESLYLTGDVAELGHWSTSPDQTAGQLLRVPNESRGVLVADLPAGAPVEFKFVKVAA
                     DGTVTWEGGANHRYTVPAGGTGTTTLTWQR"
     gene            complement(34153..34944)
                     /gene="acbG"
     CDS             complement(34153..34944)
                     /codon_start=1
                     /db_xref="GOA:Q27GR4"
                     /db_xref="InterPro:IPR000515"
                     /db_xref="UniProtKB/TrEMBL:Q27GR4"
                     /function="uptake of acarbose and acarbose homologs"
                     /gene="acbG"
                     /gene_functions="transport (smcogs) SMCOG1069:putative ABC
                     transporter permease protein (Score: 251.6; E-value:
                     1.4e-76)"
                     /gene_kind="transport"
                     /product="ABC transporter membrane protein AcbG"
                     /protein_id="CAJ81032.1"
                     /transl_table=11
                     /translation="MPIVFALYVALRPIEETNQSGYVSLPHQMTLSNFAHAWTRSGMWR
                     FFLNSVYVTVPAVLITLLLASMAAYVLSRLGFRFNIPLLILFTAGNLLPQQVIITPLYR
                     IYLAVHLPSWLSGSGLLYNSYAGLILINVSFQLGFCVFVLSNYMKTLPPAIDEAALIDG
                     ATLWSRYWRLTMPLCRPALAALATLLTTWIYNDFFWAITLISTGDRRPITSALANLQGQ
                     FVSNQNLIAAAALIAAIPTLVVYLLLQKQFIAGLSLGSTKG"
     misc_feature    complement(34912..34914)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(34995..35975)
                     /gene="acbF"
     CDS             complement(34995..35975)
                     /codon_start=1
                     /db_xref="GOA:Q27GR3"
                     /db_xref="InterPro:IPR000515"
                     /db_xref="UniProtKB/TrEMBL:Q27GR3"
                     /function="uptake of acarbose and acarbose homologs"
                     /gene="acbF"
                     /gene_functions="transport (smcogs) SMCOG1067:putative ABC
                     transporter permease protein (Score: 254.1; E-value:
                     2.7e-77)"
                     /gene_kind="transport"
                     /product="ABC transporter membrane protein AcbF"
                     /protein_id="CAJ81033.1"
                     /transl_table=11
                     /translation="MTPTIRPAPAARRRRRTLTRRDVAVAAAMLGVPLLLDLAFIWFPA
                     LASVLLSFTKWTGIGSIRMRSCADFPSAPGIPQPGCLNGVDNYRQAFTNYPDFWPAVRH
                     NAIWLVVFILLATPLGMLFAVVIDRGVRGSRFYQSVLFLPVMLSLALIGIIWELIYSPN
                     FGLINTVLGHNHNDNLIDWLGNPRLNLWALLVEASWRQAPYVMVLYLAGLKAVDPALRE
                     AAIVDGANAWQTFWRVVFPAMRPINIVVLVVTVIESLRAFDLVYITSNGNPLRGLELLS
                     VAVTQNIVGETQRIGFGSTLGVVLLVISLVPISLFLWQAFRREER"
     gene            complement(35975..37276)
                     /gene="AcbH"
     CDS             complement(35975..37276)
                     /codon_start=1
                     /db_xref="GOA:Q27GR2"
                     /db_xref="InterPro:IPR006059"
                     /db_xref="InterPro:IPR006311"
                     /db_xref="UniProtKB/TrEMBL:Q27GR2"
                     /experiment="RT-PCR, overexpression, enzyme tests, protein
                     purification, binding assays with substrates"
                     /function="uptake of acarbose and acarbose homologs"
                     /gene="AcbH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143:sugar-binding lipoprotein (Score: 161; E-value:
                     9.1e-49)"
                     /gene_kind="biosynthetic-additional"
                     /product="ABC transporter binding protein AcbH"
                     /protein_id="CAJ81034.1"
                     /transl_table=11
                     /translation="MTRFDSAGLTRRSLIGLTGAAATATLLAACGSDDKSGTTSVSDGN
                     GPITFGSNYSDEAPKAAFASLMQQATTSTTVPVTVNTTDHNTFQNNISNYLQGTPDSLA
                     TWFAGYRLQFFAAQGLLTPIDDVWDKIGGTFNDAAKSLSKGLDGHYYLVPLYNYPWVVF
                     YNKSVFQSKGYEVPASWEAFIALARKMQSDGLVPLAFADKDGWPALGTFDILNLRINGY
                     DYHIKLMKHEVPWTDPGVTKVFDQWRELAAYQQKGANGRTWQDAAKALENKQAGMMFQG
                     SNQVAANYSAKNLPDLDFFVFPAINPQYGTDYMDAPTDGFILPKKGKNAAAAKKVLQYI
                     GTAEAEAAFLKTDHWDVGLANGLIAPTYNDIQKKSVAEIGKCKSVSQFMDRDTVPDMAN
                     AMIKLIQQFIDQPTPETIATVQKSAEDQAKTIFR"
     gene            37518..39875
                     /gene="asp3.1"
     CDS             37518..39875
                     /codon_start=1
                     /db_xref="GOA:Q27GR1"
                     /db_xref="InterPro:IPR000772"
                     /db_xref="InterPro:IPR001286"
                     /db_xref="InterPro:IPR008997"
                     /db_xref="InterPro:IPR013781"
                     /db_xref="InterPro:IPR017853"
                     /db_xref="UniProtKB/TrEMBL:Q27GR1"
                     /function="putatively involved in xylane degradation"
                     /gene="asp3.1"
                     /product="putative galactocerebrosidase"
                     /protein_id="CAJ81035.1"
                     /transl_table=11
                     /translation="MRHLLMVAVTAAAIGTLAAPAPAAAATTVALNGGIVGRAFDGVGA
                     ISGGGGNSRLLIDYPEPQRGQILDYLFKPGYGAAVQLLKLEIGGDANSTDGSEPSHQHV
                     RGDINCNAGYEFWLGEQAVARNPGIRLVALPWAAPGWIGGGSFWSTDMINYDVSWLNCA
                     RQYGLTISYLGGWNERGHDSTWYKNLRTGLDNAGYSAVQIVGDDSGWGMADEFAADPTL
                     KNAVGVLGNHYVCGYLSQADSCSTTGNARSSGKPLWASEFGSQDDNAGVVPYIRTVNRG
                     YLDAEISGYMNWPLIAAITPNLPFATVGLMDAGSPWSGAYRVGRNLWANAHYAQFTQPG
                     WHYLNSSASGYLGGNRANGSYVTLKSTNNTDYSTIYETSGSTAAQTVNVTVSGGLSTGT
                     VHVWSTDMGSSNSADWFVRQADITPVGATYTLNLQPNRIYTVTTTTGQGKGTAAGPAPH
                     GLALPYSDNFDGYAVRKLPHYSEDMQGSFETRACSAGRGGTCLQQVAPLRPINWQDDSD
                     AFTLFGDTGWTNYTVSLDVNMQQAGTVTLLGRANIQNRPQNRQAAYQLRVTDNGGWSIV
                     KHTNADTDTTLVSGTRAALGLNSWHNLRLGFSGGQITAAIDNTTVGTVTDYAYGAGQAG
                     VGVVGYQTDQFDNLSVTPNSGPALNTLRGVESGRCADVPGASQTNGTQLALWDCNGGSN
                     QNFTLTDQKQLLVYGSKCLDVNAGGTADGAKVQIWDCHGGTNQQWTLNADGTIVGIGSG
                     KCLDATGHGTANGTLLEIWTCNGGDNQKWSRS"
     gene            39872..40936
                     /gene="asp3.2"
     CDS             39872..40936
                     /codon_start=1
                     /db_xref="GOA:Q27GR0"
                     /db_xref="InterPro:IPR000772"
                     /db_xref="InterPro:IPR001087"
                     /db_xref="InterPro:IPR008997"
                     /db_xref="InterPro:IPR013830"
                     /db_xref="InterPro:IPR013831"
                     /db_xref="UniProtKB/TrEMBL:Q27GR0"
                     /function="putatively involved in xylane degradation"
                     /gene="asp3.2"
                     /product="putative xylanase"
                     /protein_id="CAJ81036.1"
                     /transl_table=11
                     /translation="MKRLAALLSIGILGLALAAPAQAAESNGGVRVMPLGDSITDGYNV
                     PGGYRIGLWQRLAADGHLTDLVGSGSNGPAGLGDHDHEGHPGWRIDQLDAAIVGWIQQA
                     DPRTILLHIGTNDIGQNYDVANAPARLSALIDKIRVNAPQVQLFVAQIIPTANAANEQK
                     TQTFNAALPGIVAQKGPLTHLVDQHSALTTADLADGVHPNAAGYDRMAARWYAALQSVP
                     GSLTTLTTPPVGATVLLSNPQSRRCLDVGTTVSLWDCHGAANQQWVRTAAGELRNGADC
                     LDATGAGTANGTRLIIWPCHGGANQHFTFHPDGTIVGVPSGRCVDLNANGTANGTIVQL
                     WDCNRGANQVWSAR"
ORIGIN
        1 tggatcgaag gtcagcacga agtcgatggc atcgtcgtgg cgccgtcgcg tgcacagagc
       61 cacggtgaca tgcgggtcca cgatcaccag cgccgcctcc gactccaccc cgctcagtcc
      121 atcggtgatc gacgtgcgaa tcggcgaagg agctggcagg cccgggccgg gaccggagac
      181 acccaccagc gccgcggtcg atgccgcgtc ggccagccgc ggaatccagc cgtgtcccgt
      241 cgcgaggtcc ggatacgcgc ccaggaccac gccgtacggg ccggcgaacg gcaattgcct
      301 caagacgtgt gcggtgagcc cgtcgaggag atgccggtcc ccggtccggg cgcggtggcg
      361 agccgaggcc atatcgaacg ggctggcacc gggtacgtac aactcagggc ggggagcacg
      421 caaccgagcc gacgggtcga ccggccaatc ccgcacggcg gacagcggcc caggccgggc
      481 gaacaaccat ccctgccccc agccggcgcc caaggcgcgt gccacctgga gatcctgctc
      541 cgtctcgatg ccctcggcga tcaccatcgc accggtccgc tgggcgtatc cgcacaccag
      601 cgcggtcgtc tcgatggtgt gtgcgcagta cgggtcgcgc agcaggtgca tgtcgagctt
      661 gacgacctcc ggctccaaca gcggcaggaa ggccagcgac agccggtccg caccaacatc
      721 gtcgagcgcc agcgcaccgc cggtgcggtg cgcccgggcg gcgacctcaa gcagcgccga
      781 cgggtgcgcc gccagggcac gctcggtgaa ctccagcacg tatcggtagg tcgagatcga
      841 ggcgagccgt aatcgcaggt cctcgctgag cggccgatcc gccccggcgg gttccttgtt
      901 gatgaacacc agcggtggca ccaccgctcc gggggcctga gcgatctcat gtgcccgggc
      961 ggcgcacaac tggtccagct ccggcaccag gtcaacccgc gcagcggcct cgaacaactg
     1021 gtccgggaac tccagcgggg atcctgccgg cccacgcgca agcgcctccg cccccaccag
     1081 ccggcgggta tcgaggtcga cgatgggctg gaacagcggc tcaacggcac gctcggccac
     1141 tacacgggag atgagcgcga cagactcgtt ccgggcgtca cacacctgcc tgttcctctg
     1201 gatcacacca ccagtcccgt ccgagatggt ttccgcactt ctgctgatcg gctgacaccc
     1261 ggctcacctg agcactcgcg actccatgga ttcgaagacc tgcttatcgg cattcatgcc
     1321 tgccgcctgc tctgtgccga acacgcggac gaccttgccg acgaggacga cgataccgag
     1381 gagcgccatg acgagatcga cgaagcgttc gtgtggctgt gcgtgcccgt acagctcaag
     1441 atcgaggatc tggtggccgg cgggttgatc cgcgaggtgc ggccggagtc tgccggtgcg
     1501 gcgctttccg ggcggatgcg tgccgagtgg caggccgtcc cgcagcaagt gccttccccg
     1561 ctgacggcat cgagagacat cgttgctggg ggcgctccca tcgcaacggt gcgtccacag
     1621 tgttaacggc tggcgacaga cggcttcccg gctgtttgca agtgcttcca cgtgatgcaa
     1681 gagtttgcta gcttcgtgcg gtgcggtgac gccgctggcg gccatcgatg aagcgccggc
     1741 ctctccggac ggcgggcgcc cccgcgggca ccgcaccacg ttccccgtca cgccccgagg
     1801 agggccgcgt cttggttctg tcccgtcatc gcgacgtcat gcgtcgcctg tccgccgtgc
     1861 tggcgctcgg cctggtggtg cccctgctgc tggcgccacc gtggcgggcg tcggccgcgc
     1921 cggccggcgc ggccgagccg agcgccgcgg ccctggccca ttggggagcc gaccggccgg
     1981 cacccgccga acagttctac ttcgtcctgc ccgaccggtt cgccgacggg aacccgaaga
     2041 acgacaccgg cggtctctcc ggcgaccggc tctccaccgg gtacgacccc accgacaagg
     2101 gcttctacca cggtggggac atccaggggg tgatcgacaa gctggactac atccaggggc
     2161 tcggcaccac cgccatctgg ctggccccgg tcttcaagaa tcggccggtg caggggaccg
     2221 gcgccgccgc ctcggccggc taccacggtt actgggtcac cgacttcacc caggtcgacc
     2281 cgcacttcgg caccaacgcc gacctcaagc gcctggtgca gctggcacac cggcggggcc
     2341 tgaagatcta cctggacatc atcgtcaacc acaccgccga cgtcatccag aacgagggcg
     2401 gcaagagcac gtacgtggac aaggccgacg ccccgtaccg ggacagccgg ggccggccgt
     2461 tcgaggacca caactacgcc gacggctcgc ggccgttccc gaaggtgaac ctgcagtcgt
     2521 tcccgtacac gccggtcttc gccagccccg ccgacgccac ggcgaaggtc ccggcctggc
     2581 tgaacgaccc gaccatgtac cacaaccgcg gcaattcgct gttcagtggg gagaacagcg
     2641 agtacggcga ccacaccggc ctcgacgacc tgtggaccga gcggcccgaa gtggtccgcg
     2701 gcatgaccga gatctacgcc gactggatcc gggacgccga catcgacggc taccggatgg
     2761 acaccgtcaa gcacagcaac atcgagttct ggcagcagtt caacccggcc atccagcagg
     2821 ccgcgcgacg ggccggcaaa cccggcttct tcatgttcgg cgaggtcttc agcgccgacc
     2881 aggaggtgga gagccgatac gtccggcagg gcggcctggc cgcgtccctg gacttctcct
     2941 tccagtcggc ggcccgcacg ttcgtctccg gtgacacgcc ggccaccgcg ctggccgacc
     3001 tttaccgaca cgacgacctc tacaccgccc gcgacaccgg ggccggccgg atgcccacct
     3061 tcctcggcaa ccacgacatc ggccggatcg gctcgttcat caccaccggc ggcgccgacc
     3121 ggaccagtta cctgcggcgc gaccagctgg cccacgagct gatgttcctc acccgcgggc
     3181 agccggtggt ctactccggc gacgagcagg gcttcaccgg gccgggcggg gacaaagacg
     3241 cccggcagga catgttcgcc agccggacgc cggactacct cgacgacgac ctgatcggca
     3301 ccgaccggac ccacgcgagc gacaactacg acaccgggca cccgctctac cgcaccatcg
     3361 ccgagctggg cgcgctgcgt aaggcgaacc cggcgctacg cgacggcgtg cagatcaccc
     3421 ggtacgcggc gcccggcgcc ggcatcttcg cgttctcccg ggtcgacccg gtccgacgcc
     3481 aggaatacct ggtcgcggtc aacaacgcca ccaccgcaca gacggccacc gtcggcaccg
     3541 ccacgccggg cagcaccttc accggcgtct accgcgcggg cggtaccgcc gccaccggct
     3601 ccgacggcaa gctcacggtg accgtgcccg ccctgtccgc ggtggtctac cggggcggca
     3661 gccccatcgc ggtcccgtcg gcccggccca ccgtgcggat cagcgcaccg gccgcggggg
     3721 cgtccgtgcc gtcgcgggcc gatctggtcg ccgacgtcac cggcgatccg ctggccacgg
     3781 tgaccttcgc ggcgcaggcc ggatccggcc cgtggaccgt gatcggcacc gcgcggcagg
     3841 ccccgtacca ggttcaccac gacctgaccg gtctggccgg cggggtcacc gtgaggtaca
     3901 aggcggtggt ccgggacggt cgcggacgta ccgcgagctc cacctcgtcg ctgcgggtcg
     3961 gcaccccgga cacccacgtc gcgccggagc ggatggtggt gcactaccag cggcccgccg
     4021 gtgactacgg cgcctggcgg ttgtacgcct tcggcgacat cgacgcgtcc gcccagacca
     4081 cctacccgga cgggcagccg ttcgccggcc aggacgagta cggcgcgttc gcctgggtga
     4141 gactcaagcc cggcgccaag aacgccggtt tcgtcgtggt ggacggcaac ggcgtcaagg
     4201 acgtccagca ggaccggttc gtcgacccgg gccgacaacc ggagatctgg ctgaaagcgg
     4261 gcgacgcgac ggtgtacccg tcccggcagg acgccaccgg ccggcccgac ccgcaaccgg
     4321 acccgaagac cgccgtcctg cactaccggc gcgccgacgg cgactacacc ggatggggcc
     4381 tgcacgtctg ggacggcgcg gcccagccca ccgagtggac ggcgccgctg gccccgtccg
     4441 ggcgcgacgc ctacggtgtc acgttccggg tgccgctcgc cgacggcgcc actggggtca
     4501 gctacgtcct gcacgccggt gacaccaagg accagccgac cgatcagcgg atcgacttcg
     4561 ccgccggccg tgaggtgtgg ctgctcgacg gggtggccga gcgcctgctg ccggtgaccc
     4621 gccggaccgc ggccggcgcc gggatcgatg tgacgacctc gcgcgccggg tgggccagcc
     4681 gggacacggt ggtctggaac accggtgtgg gcagcacctt gcagccggtc ggcggtggca
     4741 ccgacgggcg ggtgtacgag ctggcctacg ccccggtcgg ggggatcacc gtggtcggcg
     4801 gggagctggc gggggcgtac cggaccctgc ggctcaccgc gcagcgtgac ggcctgaccg
     4861 agagccagcg agtccggttc ccgaagctgt ggcggtacgg cgccttccgc gtcgccgacg
     4921 ccgaccggca ccgtctcgcc acggcgttgc gcggtcaggt ggtgatcacc gaacgggacg
     4981 cctcgggcaa gctgctcgcg gccaccggtg tgggcgccgc cggtgacctc accggctgac
     5041 cggagaccgg gatgatcggg gcgcccgcgc cgagcgcgcg ggcccccgat cgcggtgaac
     5101 cggtcagctg ccgggcatct cgtagcgccg cagcccgagc cggaaggtgc cgtaccccag
     5161 caggacggtg agcgtggtga ccggcagcat ccacagcagc ggcccggcgt ccccggtgag
     5221 caggtagcgc accggtaggt aggcggtgaa cgcgaacggc agcacccagg tgagcacccc
     5281 gcgcagcacc gggtggtaga ggttgagcgg gtacgcggtg aactcgctga gctggttgac
     5341 cgccaccatc acgttgaggc tgctggtcat ccagaacgac agggaggcca ggaacgcctt
     5401 gaggaaggtg tggatcaggg cgccgccgag gaccaggggc agcaacagca gccactgtgc
     5461 cacggtcagg tgcaggtcca tcgtcccggc cgcggtgacc acgatggcga tgccggtggc
     5521 cagctccccg aacccgtccg gatagaggaa ccgttcggac agcagcgcgt agaacgggtt
     5581 caccggccgg atcaggtagc ggaagaagtc gccggtgcgc accagctgcc aggccaggat
     5641 ccacagctgg tcggtgaaga gccggtccag cccgcggggc agcagggaga acccgagcag
     5701 gaacagcgcc tgctggcggg tccagccgcc gagcgccgga acgtactgga agatcacccc
     5761 gatcagggcg atctggcagg cgatccggat gacgaagctg gccgccccga tgaggaagtc
     5821 catccggtac gcggtgagcc ggtgcaggct cgccccgcac agcaccgccg tgaggcgcag
     5881 gtaccggcgc gccgtggaga cggtcatccg ccgagcacct ccaccctgcg cagcgaccgg
     5941 ttccaggcca gggccagcac gccgtacagc agtaccgccc agagcgcctg gacaccgagg
     6001 atggcagcgg cgccggaacc gccggagtag ccgccgagca gcagccgcaa cgggctgtcg
     6061 atcaggccct ggaacggcag cagccgcagc agccgggcca cgccgtccgg gaacagcgcg
     6121 agcgggacga cctggccggc caggaaggcg acgagcgcgt tcttgatcgt acggatgccc
     6181 caggtgttgg tcgtgacgaa ggcggcgaga cccaccagga agttgatctc gaaggcgagg
     6241 atcaccgaga gcagcagcgc gacggcgaac agcagcaggt tggcgggcgg gggagcgggc
     6301 agcgacgcga acatcgcgaa accggcgagc accggggcgc cggccagcag cgcactgagc
     6361 gcggcggtcg gcaggttcac cgccagacag ctgagcgcgt agttcgccgg gcgtaccagg
     6421 gagaccgcga tgtccccgcg gtacacctcg ccggcgatca tctcgtcgat ccggttggtg
     6481 tgcagcatcc cgagcacctg cgcgagcacg atgtacgagg tgagctgtgc gaacgggagg
     6541 ccggccggtg ccggtccgcc ggcgtagacg gctcgccaca ggaacacctg caacgaggtg
     6601 gccgcagccg ccgtgagtgc gctcaggacg atggtcgagc ggtaacgggt gacggcgtgc
     6661 agtccggcga gggcgaacgg cgcgtaccgg cgcgcggcgc ggatcatgcg ccgtccccgg
     6721 cggtgaccgg ctccgggcgc gacccggcgt agatgcggcg cagcagtgtc tccagatcgg
     6781 cgtccggcac cagcacgtcg ctcaggtcga accggtccag caggaaggcg atcacctgcc
     6841 gggccgacca gcggtccacc gggaactcga cccggatccg gccggactcg gccggagtgg
     6901 cgtccacctc gggcagtcct tcggtgatga tgcgcagcgc ggcggcctcg gagacgctgc
     6961 cggcggcgta ctcgaaggtg accgcccggg tgtccaccga ccgcagcagg tcccgcatcg
     7021 ttccctggtg gacgatcgtc ccgcggtcca cgaccagcgc ctgatcgcag atgctggtga
     7081 tgtcgccgat gtcgtggctg gtcagcatga ccgtggtgcc cagttcggcg tggatgtggt
     7141 tgatcaggtc ccggaccgcc tgcttgagga ccaggtccag gccgatggtg ggttcgtcga
     7201 ggaagaccac ggccgggtcg tgcagcagcg aggcggcgat ctcggcccgc atgcgctggc
     7261 ccaggctcag ctggcggacc ggggtgttgc cgagggcgcc gaggtccagc cggtcccgga
     7321 acaggcgcat gttccggtcg tacaccgcct gcggcacctc gtagacgtgc cgcaggatgc
     7381 ggaacgagtc gaggaccggc agatcccacc agagctggct gcgctggccg aagaccacgc
     7441 cgatccggcc ggcgacccgg gtgcgctgcc ggtgcgggtc gaggccgtcg acccggaccc
     7501 gcccggtggt cgggcgcatg atgccggtca ggagtttgat cgtggtggac ttgcccgcgc
     7561 cgttcgcccc gatgtaggcg atcttgacac cggacgggac ctcgaagctg atgtcgtcga
     7621 cggcccggac cacgtcgtac cgggccgaga acatggttcg caggctgccc cgcagacccg
     7681 gctcgcgccg gtagcgcttg aagtgcttgc tgaggtgctc ggcgacgatc atgccggtcg
     7741 tgccgtccgg ccgggcatgc cgggcgtacc cgggcatggc gagtcgagat gattcacgga
     7801 tcctcgtttc ttttccggaa gatgtcgtgg cggcaacatt ttgaaattga tgattaccat
     7861 caattaaccg agtttccaca atgtcgcgcc ggtctcggcg accggctata tggaagcaat
     7921 ccgaacagtc ggccggagga tgttgtcgac ggtgtgacaa tccgcgggcg gccggcgccg
     7981 cgctgcgccg gagtgcggcc ggccatcctc gttgtccgag gtgctgaggg gcacggccga
     8041 tcgctcggta gggggagggc ggtcatccgc tgtgcggtgc gggatcagcc aagtgagcat
     8101 tgaatgcgat tgcggcggca ctcgtcaagc cgccgtgccc ggtcctcgaa atgtgaccgc
     8161 gaaacctttc ccgtccgata tggagtgacc ggcgtcataa tttgttgttt cgggcaacaa
     8221 acccatcgcc gatcctcgat atattaccag ccggcttttc cgacattcgg ccagatgaat
     8281 gcggttacag acgggaccgg cgggtggggc cggatggtgg gcggggttgc ggaggggcgg
     8341 ccggtgaacg atgcaagaac ttgctgaaac tttcaggtcc agttgcggtg ccggtttcac
     8401 cgccatagat ttcgcggtca tcgggcctcg acggttccga tccggcccgg ctgagtgtgc
     8461 ggctcgctgg gcggtgcagc gacgccgacg tcgcttgaac cccgaacttc cagcccatct
     8521 caccggatgc ggcggctatc cccttcagga gtgacccgtg atgtgttccg agccggttcg
     8581 tttcgacacc ggcgccgcga cccggcggcg gttccggtga gcaggcaggc cgacctgctc
     8641 gcccgggagt cgcgtcacct ggctccggga gcctccgaag aggcggcgct cggccggcgg
     8701 gtgttcgtcg agggccgcgg cgcgaccctg cgcgacgccg acggtgtgga atacctcgac
     8761 ttcgccgccg gtactttgac ccagtcactc gggcactgcc accccgaggt ggtggcccgg
     8821 ctcaccgaac aggccgggaa gctgtggaac gtccacgact tcgcgaccgc cgaccgcgcc
     8881 gcgctctgcg aactgctcgc cgaactgctg cccgaccacc tcaccacgct cgccttcttc
     8941 tcgaccggcg ccgaggtggt ggaggcggca ctgcggacgg tccaggccgt cgccgaaccc
     9001 ggccgcaacc gggtcggggc actgcggcac ggcttccacg gcaagacgat gggcgcccgc
     9061 atgctggtgc actgggacgt gggggaccag tcgttcgccg gcaacagcgt gctggggtac
     9121 gccccgtact gctaccggtg cccgctggag ctgagctatc cgtcgtgcga ggtccgatgc
     9181 gccaccctgg tacgccggca catcgccgag aaacccaacg tgagcgccct gttcttcgaa
     9241 ccggtgctgg gcgcggccgg cgtgatcgtg ccgccaccgg gctactggga gcagatcgcg
     9301 gccgcgtgcc gggacaacgg cgtactgctg gtcgccgacg aggtgctcac cggcggcggc
     9361 cggaccggaa cctttctggc cagcgaggcg atcggggtcg ccccggatct ggtcacgttg
     9421 gccaagggca ccgcgtccgg tttcccgttc gccgtgctcg ccgggcgtga cgaggtgctg
     9481 cggcatcccc gggccgggct cgccggatcg accgcctcca cctacgccgg caacccgctc
     9541 gggatcgccg ccgcccacgc caccctctcg gtgatctccc gcgaccggct gatcgagcag
     9601 gtccgggacc tcggcgcggt gctggccgac cgcctggccg agatgcacga ccggcacccg
     9661 cacctgggcg acgtgcgcgg catcggcctg ctgcacgggc tcgagttcgt gcacgaccgg
     9721 cagagccggc ggccggcccc ggagatcgcc cggcgggtct acaccaccgc cctcgacgcc
     9781 ggtctgcgca ccgccatcgg cgggcacatc atccggctcg cgccgccgtt cgtcatcgac
     9841 gagaccgagc tgctgcgcgg cctggacctg ctggaccggg cgattaccga ggccgggcgg
     9901 gtgacggcat gacaccccgg ccggtcagca cgatcgacgt gagcctcgcc agcctgctgc
     9961 gcaccgccga ctggccgcac gaggatctgc gcggtcccgg cggggtgcgg atcctcgacg
    10021 aggcgatcct cggcccgtcc cggttgctga tcgtcgcggc cgaacggaac cccgagagcc
    10081 gctacttcgt cgccgttctg cgccacgatc cgtcccggga ggccgtcggc gacgccgccc
    10141 acgaccgggc cgtggtccag gcgatgcgcg agcggctggc actacccacc gcagccggcc
    10201 atctgatcgt cttcgacggt gaccccgcgc cgttccgagc cacccggccg ttcgaccccg
    10261 ggtggtcgac caacgccctg tcgctggccg atctggacgg gacactgcac atccacaagg
    10321 cgtaccggct ggtgtcggcc gccacccggg aaccgcatct gctgcggctg atgcatcgcg
    10381 gcggccgtac ccagcgatgg gccggcgact accactacgt ggagcagccc tccgggcgcc
    10441 gctacccgct gggcctgctc tacgcctatg ccgaaggcga cagcctcgac ctgccgctgc
    10501 ggcacagcat ccggtcgatg tggccggcgc tgctgggcgg caccgaaccg gccggcgcgg
    10561 tgacggccgc gcagcggtcc atcgcgggcg agctgcccgg cgtcggccgg ttcctccgcg
    10621 acttccatac cgaactggcg cagcggctgg aacccgcgcc gacgttcccg gtgaacgcct
    10681 acctgcggga gaccgccgag cgggtggcgg cgctggggtg ccggatcagc gccgacgaac
    10741 gttacccccg gccggtgcgc gaggcggtcg tcgccgccct gaccggcgaa ctggaccagg
    10801 ccaccaccag cgcggtgcgg gtgccgtggc cggccggccc gtcgcacggc gacctgcacc
    10861 tgtcgcacat cctgcgccgg cagacaccgg acggctggcg gctgtgtgtg atcgacctgt
    10921 ccacgcccgc ccccgacccg gccgacccgc tcggcgccgc ccagtcaccg tggcaggacc
    10981 tggtggcgct gctgcgcggg ctggagatct tcaccgccga cgagttcgtg caccaggcgg
    11041 ccctgcggct cggcgccgac caggacgaca cctgccggac cgtgctgctg atcagtgccg
    11101 ggcagacccc ggacacgccg ggttggaccg ggtcccggct caccgcgctg cggcggatgc
    11161 acgacgcggc gtcggtgtgg gccggacagg tccgccggat gctgctgtcc ggttatgccg
    11221 acggcggcga ggcggccgag gagcaccccg cctggcggat cttccggctc cgccgtctgt
    11281 tgcacgaact ggactacgcg tacgcccacg accagcacta ccacgcggcg atcaaccttc
    11341 gacacgtcct ccagacctac cggccgccgg tcaccgggga gagctgagca catgcacatc
    11401 atcgagacgt acttcgaatg cggcggcttc gaccaccggt tcatccaggg cggcacctcg
    11461 gtctatctct ggcagctgtc gcgtggcctg gccgacctgg gacaccgggt ctccatcgtc
    11521 acaccggcgc acggccgcct ggacgatctg cgccggctgc acgaggtcga ggacctgccc
    11581 ggcaccgacg agtacgaact gccgctggtg ctcgacccgc gcgtgtgggg cgaacggttc
    11641 ccggcccaga tggacatcgc cctgcggacc accgcgcatc ggatccggct ggcgggcgtg
    11701 gacctgtact tcctctccaa cgaactgctc gatcagttgc cggaccggtt ctatcccccg
    11761 tacgagagca agggggttga tctggtcttc ttcaagccgc tcgcctatca ggtggcggcc
    11821 atccggttca tcaggtcgca cttcggtgac cagcgcgcga tcgtgcacgc acacgagccg
    11881 ttctaccact acctgatgcc ggccgccttc gccgcggacc cggccaaaca cgtggtcagc
    11941 acggtgcaga gcaacatgcc gatcaacaag tcggtgtacc gggccgaggt ggcgcggctg
    12001 ctcggcttcc tcggcgcccc gaacgcgctg cccgccgacg atccggccgg cagccgttcg
    12061 ccgcacaccg tggcgatgag ccagtaccag cagctgaccc acctgcacta cgaatacccg
    12121 ccggaccacg tgcgggtcta cgacctggtg gccgagcacg ccgaccggat cgacttcctg
    12181 tcgccggggc accgcgacta ctacacctgc ttcgccgaca ccccgttcgc gcagctgttc
    12241 gccaccctgc cggtgtcgcg gacggtacgg cgcaacgcgg acaagacgtt cgtcggcggc
    12301 tgcgccgtcg gtgacgagtg ggtgaccggc gagctgcccc cggtcgaccg ggagaaggtg
    12361 ctggccgggc tcggcctgga cccggacctg ccggccttct accacaacgc ccggtacgcg
    12421 gtcaaccaca aggggcaggt cgagctgatc cgggccgtcg accgggtgct gagcggcggc
    12481 gtgcgggcca gcttcatcgt gcgctgcctc agcgacgccg ggatcgccga cccgctcttc
    12541 cacgaggtgg tggcccgcca cccgggccgg gtgaatctgg agtggcaccg ggtgccggag
    12601 gaccagctgc gggagtacgc ccgagccgcg gacttctgtc tcttcccgtc caagttcgag
    12661 atggacacct tcctgatcgc ccagggtgag gcgatggctg ccggtgcggt accgatcgcc
    12721 accgcccagc tggggatggc gcacttcggt cacgtcgccg acccgctgac cgggccggac
    12781 gcggcgacgg ccaccggatt cgccgtcaac cgctcgttcg ccgaggacga tccgctgctg
    12841 gtccagggcc tgaccgagca gatccgccgg gccgtcacgc tctggaacga gcagcccggc
    12901 cagtaccgcc ggttgtccgc caacgccgtc gcccgggccc gcgagttcac ctggcggcgg
    12961 gcggcccagg cgcacgaggc cgcgttcgcc ggggtgtggg ccggccgtac cccccgcctg
    13021 ccggtcggtg acctgctgcg gttcggctgg ttcgacgagc tgcccgcgga cgcctggacg
    13081 ctgcaccgcg acgagatcgc ggaggtggcc ctggcccacg gcgacgccga cgcctacctg
    13141 cgctgccggc ccgacgacct cgacgccctg gcggcactct tcgagcgggc ctgggcccgg
    13201 gccgacttcc cggcctgcgc gcggaccgta gagctggccg aggagcaccg gcaggagcgg
    13261 gtgccgcagt ggcgggcccg gctcgccggc cgcggccgca tcgaccgcga cggtcggctg
    13321 cactaccgtc cgccgtccgc cgaacgggtc gaactggtct tgcccgacct ggccgaaccc
    13381 ctgcgcggaa cggtcaccgt gaccgcgatg gctccgaccg gcgacacctt caccggacag
    13441 ctgccggccg gaacccggcg tgccgacctg ctgctcaccc tcagtgacgg gcgcaccgtc
    13501 tgggacgagg tgacggcatg agcacgggcg tacgggcggt gctgctcgcc ggtggtgagg
    13561 gacggcggat gggagcgctc ggcgcgggcc ggctcaagcc gctggtgccg ttcgggggcg
    13621 cggcccggct gatcgacttc agtctggcca atgcccgcga ctccggcctg gaccaggtgc
    13681 tgctgctgtc gcagtaccag gagcggcagc tgatggacga cctgcggcgc acctggtggc
    13741 agccggggtt ccgggtgcac ttcgggccgt acgaccgggc ctacaccgac gggatcccgg
    13801 tggagtacga gccgccgacc gggccaccgg agcggggcac cgcggacgcg ctgatccgca
    13861 aggcccccta cctgttcggg ccggatgtca ccgaggtgct ggtgcagcac gccgatcacg
    13921 tgtaccgctt cgactaccgg ccgatgatcg ccgagcaccg cgcgtccggt gccgcgttga
    13981 ccgtgtccta ccagcggatc gaccgccggt acgtgcacct gttcgggatg gtcgagttcg
    14041 acgaccgtaa ccgtctggtc tcgttcgtgg agaagcccgc cgaaccgacc agcgacctgg
    14101 tgttcgccgc gttctgcgtg ttcgacgccg cggtgctgca ccgctacctg gaactgctgg
    14161 acggcaccga ctggcagcac gacatcagcc gcgacgtcat cccggcgatg ctggccgccg
    14221 gcgagcacat ccgcggctgc ccggtgcccg gctactgggc cgacatcggc accgtcgagc
    14281 gctatcacga ggcccacctg tcgctggtgg gcacaccgcc gtcgctggcc gtcgacgcca
    14341 tgccgtggac cgtggcgccc cggaccgccc gggcactggt gacctcggcc gacggtgtgc
    14401 ggcacagtgt cgtaccggcg gacctggtca accacggcac cgtcgagcgc agcgtgctct
    14461 tcccggcggc gcggatcggg cccggcgcga cggtgcgcga cagtgtgctg ctgcccggag
    14521 cggtggtgcc ggccggcgcg gagatcgacg gcgccgtggt gctcgaggac ggcaccgtcc
    14581 agcaggtcac caccggagcc cggcgatgac cggcgccgtc cgggccgtgc gatcccgtga
    14641 ggtgtaccgc aacccgtgga tgagcgtgcg cgaggacgac atcgtgcacg ccgacggctc
    14701 gccgggcagc tacggggtcg tcaccaaacc cgattacgcg ctgatcatcc cgcgggacaa
    14761 cggcctgctg cacctggtgg agcagtaccg ctacccggtc ggcgggcggt tctgggagtt
    14821 cccgcagggc tcgtggccgg ccgacgccgc cggcggtgcc gctgacctgc tcgcccgtac
    14881 cgagttggcc gaggagaccg ggctgcgggc cggccggctg acaccgctgg ggcgcatcca
    14941 cgtcgcgtac ggctacgcca gccagggctg tcacgtcttc ctggccgaac agctcacagc
    15001 ggggcgctct cagcgggagc gcaccgagtc cgacatgcgc cagcgtgccg tggacgccgc
    15061 cggctgggcc gacctggtcg gctccggccg gatcaccgac gccgcgacgc tcgcggccta
    15121 caccctgctg cggatgtacg acagcggaac gcgacagccc atgccggaag gagccgaatc
    15181 gtgcacgtgg tgagcttcgc cttcgaagcc ctcgccttcg acgtagggat gatgcgcggc
    15241 gggctcgccc cgctggcctg ggaactggcc cgccactacg ccgcccaggg acaccgctcc
    15301 tcgatcgtca ccccggcgca cggccgcctg ccgtacctcg ccgagcggta cgacctggtc
    15361 gaactcgact accgggacga gcatgtcgtt cccgtggtcc cggaccccga cgtctgggcg
    15421 gggcagcccc gcgaactggg cctgcccctg gtcacccggg cccacctgct gcggcacgag
    15481 ggcgtcgaca tctacctgct cagcgacgag tacctcgatc tgctgccgga gcggctctac
    15541 ccggccggca cgagtgaggg cagcgacctg gcgtacttca aaccgctggt gttccaggtc
    15601 ggtgggctgc gcttcctgca gtcccggctg gccggtgacg agcccgccgt cgtgcaggcc
    15661 tacgagccgt actaccacta cctcctgccc ccggtgctgg ccggcgaccc gcggttccgg
    15721 gtgatgtcca cggtggccag cagcatgccg atcgacctgg gtgtgtaccg gccccaggtg
    15781 gaccgcctgc tcgagcactt cggcgccggc accgacctgg accgctatgt ggagagcccg
    15841 gtcgcggccg gcgccgacca tcccgcggcc acccgcgagg cggcgctggg cgcggcgatg
    15901 gccggatacc tgccgacgac ccggctctcc agcgggcggc ggcgggccga ctacgtgggc
    15961 ctgttcgcgc tgatcaccga ccactgcgac acggtggact tcctgacccc ggggcagcgg
    16021 cggttctact cgacgttccg ggacaccccg tacgaggcgg cgttccggcg gaccgcggtg
    16081 gcccgggtgg tccgggagaa cgcggcgaaa cagttcgtcg gcggctgtgc gctgccggag
    16141 aactggctgc ggcgggaccc ggccgaggtg gaccgggcgg cgtacctctc cgggctcggg
    16201 ctggacccgg cgctgccgac cttctaccac gtgggccggt actcgccgca ccacaagggt
    16261 caggtggagc tcttccgggc ggtcgagcgg atcctcgcca ccgacacccg ggtcaacttc
    16321 gtgctgcgct gcgccacctc ggccggcggc ggcggcgcca ggatcggtga ccccgccttc
    16381 caggcggtgg ccgaccggca ccccggccag gtgcggctct tctggaccat ggccgacgag
    16441 gacgaactgt tcaccgaggc ggtggcggcg gacttcgggt tgttcccgtc caagtacgaa
    16501 ctggacacct tcctgaccgc ccaggggcag ctgtgcgcct gcggcgcggt gccgatcggg
    16561 accgcgcagg agtcgacccg gcactaccgg caccagctgg ccaccgacca tccgctggcc
    16621 accggattcg ccctgccgcg ctccttcacc ccggacgacg aacgtctgac cggcgctctg
    16681 gtgcgtacca tgcgggaggc gctgcggatg taccgcgacg aaccgggcga gtaccggcgg
    16741 ctggccggca acgccgccga actcgcccgc accttccgct acgccgaggt gtcccggcga
    16801 cggctcgccc acttcgcgaa gctgctcgac ggcacgccga cagcggccga cccggagcac
    16861 gtcatcgggt gcggctggtt cgaccagttg gacgccgcgc agtgggcggc ccacctgccg
    16921 cagatccggc gcgaagcgat ccgcctcggt gacctggaga cgctgcgccg ctgcggcccg
    16981 gtcgacccgg gcgcgctcgg cgcactgtac gaggccgcgt accggcgtgc cgacttcgac
    17041 cggtgcgtgc gggtcgcgga actgctgggc gaccggggca gcgaggcggt gtcgctgcgc
    17101 cggcgctgcc gggtacggcc gcacgagcag ggctgggaga tccagtaccg ggcgccgggc
    17161 gccgagcagg tggccctggt ggtcggcggt accgcccacc ggatgcacgg ttcggccggc
    17221 cggttcagca cggtgctgcc cacggtgccg atgccgtcac cggtgttcct gctgacgctg
    17281 gcctccggac ggtacgcgtg ggacgcccca ccggccaccg cacacctcgc cgacctcgcc
    17341 ggtcagccgc acccggcgca gccggtcggg gccgggggcc gctgacatgg acggcatcgg
    17401 caccacaccc ccgcgcgacc accgggtcgt cgcgaccgac ctcgacggca ccctgctgcg
    17461 ctccgacctg accgtgtccg cccggacccg cgcggcgctg cgcgacgccc gggcggccgg
    17521 catgatccac ctcgcggtga ccggccgccc ggtgatcgac acccgccggc tgctcgccgg
    17581 gctgggctac accggcccgg cggtctgcgg tcagggcgcc caggtgtacg acttcggcac
    17641 cgaccggctg ctgctgagcc gcagcctcga caccgacctg gtgcgcgagc tggtgcgccg
    17701 gatcgcgcag cggaccggtc cgctcgcgct ggccgcggtg agcgccggcc tgggcaccga
    17761 gttcctggtc accgccggtt tcggtgcccc ctaccagcag catcgctggc agctcgtcga
    17821 cgagccggac ctgtggcgtg cgccggtcgc caaggtgctg atccggcacc cggaccacga
    17881 cgacgacacg ctcgcggcac tcgccgacga ggtctgcggc gcggcgctgt cggtgatgca
    17941 cgccggtccg ggcctggtcg aactgctgcc cggtgacacc agcaaacgca ccggcctggc
    18001 ctttctcgcc gccgaactgg gcttcaccgg ggccgacacc atcgccttcg gggacatgcc
    18061 caacgacctg ccgatgttcg actgggccgg gtacggcgtc gcgatggcta acggccaccc
    18121 ccggctgcgc gaccgcgccg acgagatcac tgtcagcaac gacgcggacg gcgtggccgt
    18181 ggtgctcgaa cgtctgcccg ccgtccgggc cggaaaccga aaggcaagcc tgcgatgacc
    18241 accacgacgg atgccgcgct gatcgagctg gccggacggt acggggtgtc ggtcgactgg
    18301 accaccgacc gcggcgagcc gcggacggtg ccggccgaca cgatccagcg gatcctggct
    18361 gtgctcggtg tggacgcgag ctccggcccc gcgatcgccg ccgcgctgcg tgccgcggac
    18421 gacgacgccc ggcaccggct gctgccgtcc tgcgtggtgg tgcggcaggg ggaaccggcc
    18481 aggggagtcc acccggtggc cggggccgcc tatgtggtgg cgaccgagga cggtggccgg
    18541 cacgagacgg ccgacccgcg caacgacctc ggccgccttc cgatcggata ccacacgctg
    18601 cgcgtacggg tgggcgaccg gtccgccgcc gcgccggtga tcgtggctcc ggccgtcctc
    18661 ggcaccccgg accggcggca ctgggggatg ctggcgcaga tctactccgt actgtccgaa
    18721 cggtcctggg ggatgggcga cctcggcgac ctggccgacc tgacccgctg gtcggcccgg
    18781 ctcggggcgt cgttcgtgct ggtcaatccg atgcacgcct acgtgccgga ccgcctggcc
    18841 gaccccacgc cctaccggcc gggcagccgg cggttcgccg acccgatgta tctgcggctg
    18901 gccgacgtcg ccgagtacgc gaccgcggaa ccggcggtgc gggccgaact cgaccgggcc
    18961 gcccgtcagg gacacgaact gaccgccgag gtgctgcacc ggaacgcgct gatcgaccgg
    19021 gctcgggtgt ggccggtcaa gcggaacgcc ctggagcggc tctaccgggc accccgcacg
    19081 gccgggcggt ccgcggctct ggccgccttc accgcccgcg agggccgggg tctcgaggac
    19141 tacgccacct ggtgtgcgct ggccgaggtg tacggcaccc gctggcgttc ctggccggcc
    19201 gctctgcaat ccccgcacgg cccggcggtc gccgccgccc gccgcgagct ggtcgaccgg
    19261 atcgatttcc accgctggct ggcctggctc gtcgacgagc agatggccgc ggcccaggcg
    19321 gccgccgtcg ggtccggcat ggcgatcggc gtgatccacg acttggccgt cggcgtcgac
    19381 ccggagggtg ccgacgcgtg ggcggtgcag gatcatctgg ccggcggtgt cacggtgggc
    19441 tgcccggccg acgacttcaa cccgctcggg caggactggg ggttgccgcc gtggcgcccg
    19501 gacaccctgg ccgaagccgg ttaccggccg ttcgccgacg tgatccgcgg caccctgcgg
    19561 cacagcgggg cgctgcggct ggaccacatt ctcggcctgt tccggctctg gtggatcccg
    19621 gccgggagcg gcgcccgcga cggtgcctac gtccgctacg accacgaggc catgctcggg
    19681 gtgctggccg tcgaggcgtt ccgggccggg gcgatgatca tcggcgagga tctgggcacc
    19741 gtccatccgg cggtccgtgc cgaactcgcc gaccggggca tcctcggcac gtccgtgctg
    19801 cgcttcgagt accagggcgg atcggagaac cgcagcgggc cgctgccggc cgaccagtgg
    19861 cgtgccggct gcctggccac cctcaccacc cacgacctgc cgagtacggc cgcctggctc
    19921 agcggtgagc acgtggacct gcaggaccgg ctgggcctgc tgaaccggcc ccgagccgag
    19981 gtggccgccg acgcggcggc cgaacgtgac ggctggctgg ccgagttgcg gcgcaccggt
    20041 ctgctggagc acgagaccgc cgtaccgggg atgagcgccg agtcgctggc cctgcaccgg
    20101 ttcctggccc ggaccccggc ccgcctggtc ggagtgtggc tgcccgacct ggtcggcgac
    20161 cggaggccgc agaacctgcc gggcaccagc accgagttcc cgaactggca gctgccggtc
    20221 gccgacgccg acggccggcc ggtggcgatg gacgacctgg cgtcctcggc cggcgcccaa
    20281 gcggtcgccg gcctgtacgc cgcatcggcc gagccggcca ccacaccctg acctcgctga
    20341 cccgcacctt tcaaggagat ccatgtcgga gcacaccgac gtcctcgtcc tcggcggcgc
    20401 cggcgtcgac accatcgcct acgtgcccga actgccgctg ccgttccagg acagctacgt
    20461 ggtcgcggcc atcgaaccac gagccgggca gaccggcgac aacgtcgctc tcggcctgca
    20521 cacgctgggc ctgcgcacga tgcacgtcga cgtgctcggc gacgacccgg aaggtgacct
    20581 ggtccgggcc ttccacaccc ggcacggtct gccgttcgcc gccctgccca cggccgccgg
    20641 caccaagcgg gcggtgaacc tggtcggccc ggacggccgc cggctgtcgc tgtgggacgg
    20701 cagccgggaa gccgaggagg accgctaccc ggccgccctg atcgccgcgc acaccgccca
    20761 cgcccggcac gtgcacgtct gcatcacccc gcccgggcag cacgtgttcg gccagctcaa
    20821 cgacctgccg gtcaccgtct ccaccgacct gcacaattgg gacggcgcct acgagggctt
    20881 cgaggtctac gccttcaacg ccgacctggt gttcctgtcg gcgaccgcgc tgaccgacgt
    20941 ggccgcgacg atgcgccgcg tcatcgaccg gggccgggcc cggctggtgg tggccaccga
    21001 cggcgcccac ggcggatcgg tgctggtgcg cggcgagacg gaggtccggc ggtacgcggc
    21061 ggtggccccc gaggcgccgg tggtggactc caacggcgcc ggtgacgcgt tcgtgtccgg
    21121 cttcctcttc gggcacctgg ccggcgaacc gctggagacc tgcctgcgct acggcgcgat
    21181 cgccggcgcc tacgcgtgca ccatccccgc cacccgggcc ggcgccatcg accgggccgc
    21241 gctgctgcgg ccggcggcgt gaagcggcca ccgcaccacc cggtcacggt ggccgacgtg
    21301 ggcggcaccc acctgcgctg ggcacggtgg tcaccggacg gcggactggg cgaagtgcac
    21361 accacgccgt ctccggggca cgcccggcgg cccggcgccg gtgccgccga cctgcaggcg
    21421 gaactgatcc gcgagctggc gtcgcgggtc gagccgggtg cgcgggccgg tgtctcgctc
    21481 ggcgcggcca tggaccacca cagtggtacg gcgtacgcct ccgcgccgtt gtggggtccg
    21541 caggtcagcc cgttcgacgt gccggccgcc ctgcgcgccg cccggccgga cgtgcactgg
    21601 accgtggtca acgacgtcac ggcggggctg ctgcacctgg ccgagatggt tcgcgacgcc
    21661 ggcgtccgca aggcgtgcct ggtcacgatc agcaccggca tcgcctgccg gacgatggac
    21721 ctgcgcaccg gcggtatccc ggtcgacgcg gccggcctcc agggcgagat cggtcacctg
    21781 ccggcgaccg tgctggccga cggggtgccg gtggtgaccc gctgcgactg cggtgagccg
    21841 gggcacgtgg cggcgtcctc gtccgggccg ggcattcgac gggtcgcggc cgtcctggcc
    21901 cggcgtgacc cggccacctg ggcgggctcc gggccgacca cccggatgat ggcgggctcg
    21961 ggcttcgagg acgcgttccg ggccgctctg gacgacggcg atccggtcgc ggcggacctg
    22021 ctgacggcgg tgaccgcccc gatcgcggac ctgctgcgga ccgccctctg cctggacccg
    22081 gaactcgacc tgatcgcgct gaccggtgga gtcgcccacg ggctggaacc gcactactcg
    22141 gcggcggtgc acgaccacct gcggcgccgg gggctctacc tgacctccga gcgggagccg
    22201 gactggttga ccgggcggat ccgggtcgtc ccgccggcga cggccgatcc gttggtcggc
    22261 gccggtctgg ccgcactggc ggcggggccg gtcccggcgt actccggtgg tggccgggaa
    22321 gcgttggtcg ggcgatgagc cggcaccgcg cgatcgtgcg caccggcacc ggcgtggtgg
    22381 tcgccgacgt cccgaccccg gtgccggggc cgggagagct gttggtcggc accgagtggg
    22441 cgggactgtg cggcaccgac atccagatgc tgcgcggcct gcgcgacgat cccgaaccga
    22501 tcatcggcca cgaggggatc gcccgggtga tcgcggccgg cgacggcgtg cccggcacgc
    22561 tgcggccggg gaccctggtg gcggtcaacc cgacccaccg ggacgatccg tcgttcctgc
    22621 tcgggcacaa cgttcccggc ctgctgcagg aacggacgct gctgccggcc accgcggtct
    22681 ccggtggctt ggtgctcccg ctgccggacg gcaccgacgt cacgctgggc ccgctgctgg
    22741 aaccgctggc cgtggtcagc tatgcgctga gccagctcgg cgccgtccgc ccggccaccc
    22801 tggtgatcgt cggcgacgga acggtgggtc acctggccgc ccgggctgcg gtgacctggc
    22861 tggcggagcg gccccgggtg gtgctggtgc accacacggc agcggggcgg gacttcagcg
    22921 cggccgggcc gcatccggcg gacgttctgc tcaccaccgg cgagctggcg ggcagaccgc
    22981 tgccgggacc ggtggccgcc ctgctggcga ccccacggga cgcgactgtc gaggccctgg
    23041 aggcggtcct ggccgcggcc ggcgccgatg tgctgatcga cgtgctgggc ggcctgcccc
    23101 cgggcgcgcg atcggcgatg ctgcccggtg tcgatctcac cgccgtgcgg gcggccaact
    23161 gcggcggctt cccggaaccg gctctggtca ccaccacctc cggcggaacc cggctcttcg
    23221 ggcatcgcgg ggtgggcaac gcgcacctgc gggcggcggc cggcgagctg gcccgcgacc
    23281 cggaccggta ccgggatctc gtcacccatc gcagcgatct ggccggcgcg gcccggatca
    23341 tgaccgcgct ccggagcggc cgggaccgga tcatcgacgg ccgccgactg gtgaagctcg
    23401 cgatccaggt caatgtcaga gaggatcatc gatgagcggg actctggtgg gccgccgcgc
    23461 cctggtggtg ggcggaacca cgggcatcgg ccggggcatc gccgacgcgt gggccgcggc
    23521 cggcgccgag gtgaccgtct gtggccgcag cgagccggcc ggcgatggcg ccgccgggtt
    23581 gcactgggag ccgctcgacc tgacccggac cggggaggcc ggtgcgcgcc tggaacggat
    23641 cgccggtgac cgggtcgatc tggcctgctt cgccgcggtc tcctacgggg cccggcgcgc
    23701 cgtcttcgag gacgtggcgg tggacgaatg gcgtacccag ctggacatca acgtgcacgg
    23761 cctgtggctc accctgcggg cggcactgcc ggggctgcgt gccgcccggc ccggcctgtt
    23821 cgtgggcgtc tcgtccgagg tggtctacaa cgccgggccc ggccgctccg ggtacaccgc
    23881 ctccaaggcg gccgcgaagg cgctgctgga gtcggtggcc caggaggagg acgagagccg
    23941 ggtccggatc gtgcaggtgc tgccggccgg gatggtcgat actccgagca tccggcgccg
    24001 tcgcccggcc ggcttcgact acagcgacta catggtgccc gccgatttcg cgcgcaacgc
    24061 gctggaactc gccgccacgg ccggcgccgg ccaccacggg gacagcctgg tggtcgacag
    24121 gggcggcgac tggtggtcgg tgcgcgagcg gatgccggtg tcgcagagcc ggccggtgcg
    24181 gacgtgacct gccgggtggg gctgaccgag tggcggctgg cgccctcggg tgcggcggcc
    24241 atccggctgg ccgcggcggt cggtgccgac gggatccagc tcgacttcgg cggcccgggc
    24301 cgtggcgtgc tggtggacgg cccgggccgt gccgggcagc tgcgggcggt cgccgacgag
    24361 gcgggagtgg acctgctcgc gctggccggc aacctgctca acgacatcgg gctcacgtcg
    24421 cagccggcgg tggtccagcc ggtgctggcc cggctggccg acacggcgac cgagctcggg
    24481 gtgccgctgc tcatcgtgcc cagcttccgg cgcagcgcga tcaccgacgc gatgtccttc
    24541 acccgcacag cagccgccct gcgctgggcc gtgtcgctgg ccgaggcccg gggaatcgtg
    24601 ctggccagcg agaacgtcct gcccccggcg cgggcccggc agctggtcga ggaggtcggc
    24661 tcaccggctt tccggctgct gctggacacc ttcaacccgg tccggtacgg actcgacccg
    24721 gcctggctgg ccaccgagct ccggccgtgg tgggccgacc agatccacct caaggacggc
    24781 ccgccggaca ccgggccgtc gccgctgctc ggtgcgggac agggcggggt gcggcgcacc
    24841 ctgaccgcgc tcagggggag ccccgcaccg gtacgggccc tggtgctgga gaacgactac
    24901 cgcgacggcc acggtgcgcg gctgcgagcg gacctggagt gggcccgccg ggccgcggtg
    24961 aacgcgagag aatccgagaa agggaagctg acgtgagtgg tgtcgagacg gtaggggtgc
    25021 acgcggatgc gcaccgcgac tcgtggcagg tgcgggccca gaagcagatc acctacgagg
    25081 tgcgcttccg ggacgacgtg ttcgggctgg actccaccga cctgctggag gccggggcgg
    25141 acggggccgg ttcacggcgg cggttcgtgg tggtggacag cgccgtcgac gccttgtacg
    25201 ggtcccggat ccgggagtac ttcacccatc acggcatcga tcattcgatc ctggtgatgc
    25261 gggtgggcga gacggtcaag gacttcgaca cggcgggccg catcgtcgcc gcgatggacg
    25321 ccttcggact ggcccgccgc cgggagccga tgatcgtcgt cggtggtggg gtgctgatgg
    25381 acgtggccgg tctggtggcc agcctctacc ggcgcggcac gccgttcctg cgggtgccga
    25441 cgacactggt cggactgatc gacgcgggtg tcggcgcgaa gaccggggtc aacttcaacg
    25501 gccacaagaa ccggctgggt acgtacgccc cggctgatct gaccctgctg gaccgccgct
    25561 tcctggccac cctggaccgg cgccacctca gcaacgggct cgccgagatg ctcaagatcg
    25621 cgctgatcaa ggatgccgag ctgttccagc tgctggagcg gcacgggcgg gtcctgatcg
    25681 aggaacggtt ccagggccgt accggaaccg gtgaccgggc cgccgtccgg gccctgcgcg
    25741 cggccaccca tggcatgctg gaggaactcg gccccaatct gtgggagagc cggctggaac
    25801 gcagtgtcga ctacgggcac acgttcagcc cgaccatcga gatgcgcgcg ctgccggctc
    25861 tgctgcacgg cgaggccgtg tgtgtggaca tggcgctgac cacggtgctg gcgtaccggc
    25921 ggggtctgct cgacgtcgcg cagcgggacc ggatcttcgc ggtgatgacc gccctgggcc
    25981 tgccgacctg gcatccgctg ctcacgccgg aggtgctgga ggcggcgttg caggacaccg
    26041 tccggcaccg ggacgggtgg cagcggctgc cactgccggt ggggatcggg ggtgtcacgt
    26101 tcgtcaacga cgtgacggcc ggccgagctg caggccgccc gcgctgatgc agcaccggct
    26161 cgccgaggac gccctgctgc tgcgcgccct agctcgggcc gcggacgccg atcgccggaa
    26221 gcgaccggcg tccgtccgcc caccggttgc cgtcaggtcc accaggaacg gttggcgcga
    26281 taccacgcga ccgtttccgc gatgccgtcg gtgaaatcga cccgcggccg gtaaccgagt
    26341 tccccggcga ttttcgaata gtcgagagaa tagcgccggt cgtgaccttt gcgatcggtc
    26401 acgaaagata tgcgcgaagc cggggcgccg cacgcctcga ggaggatctc ggtcaattcg
    26461 agattcgtcg cctcccaccc accgccgatg tgatagacct cgcctgcccg gccggcaccc
    26521 agggccaggg cgagaccgcg gcaatggtcg ctgacgtgga gccagtcgcg gatgttgcgg
    26581 ccgtcgccgt agaccggtac gtcgagcccg tcgagcagcc tggtgacgaa cagcggaatc
    26641 attttctccg ggaattgccg gggcccgtag ttgttcgagc agcgggtcac cacgacgtcc
    26701 atcccgtgcg tctggtggta ggccagagcg aggaggtcgg acccggcttt gctcgcggcg
    26761 tacggcgagt tgggcgccag cggatggccc tcggcccacg agccggtgtc gatcgacccg
    26821 tacacctcgt cggtggaaac atgcaggaag cggccgatat ggtggcgtag cgcggcgtcc
    26881 agtagcacct gagtgccgac caggttgctg gccacgaagg ggccggaggc gaccaccgag
    26941 cggtcgacgt gggtctcggc ggcgaagtgc gccacggtgt cgtgccgcgc catcagcccc
    27001 tcgattagac cttcgtcaca gatgtcgccc cgaacgaagc tgaaacgagg gtccgccgac
    27061 gcttcggcga gatttctgag attgcctccg taacccagtt tgtcgacgac cgtaacctgc
    27121 gtcacgggtt gtggtgtggc aatgtcgcca ctgatcaggg aagttacaaa atgggacccg
    27181 ataaagccgg ctccgccggt gaccaagatt ttcatcgccg ggattgtagc aatgccgcca
    27241 atgggtgccc gatgttcggc cgagccattt acggggcttg ctgatatggt cggtcacgtg
    27301 cgcggaatat tgctggccgg gggaaccggc tcacggcttc gaccggtgac ctgggcggtt
    27361 tccaaacaac tgatgccggt ctatgacaaa ccgatgatct actatccgct ggccacgctc
    27421 gtcagctgcg ggatccggga gatcctggtc atcacgaccg agaccgaggc cgcccagttc
    27481 cagcggttgc tgggtgacgg ctcgcagtgg ggcctgcgtc tggagttcgc cgtgcagcag
    27541 cgccccgggg gcatcgccga ggccttcctc atcggcgagg agttcctggc cggtgggccg
    27601 gtggcgctca tgctcggcga caacctgctg cacggggtgg acttccgccc ctgcgtgcag
    27661 cgggcacgcg agacggccgg tgggcacgtc ttcggagtgg cggtggccga cccgtcggcc
    27721 tacggggtgg tcgagttcga cgccgccggg cgggtgctgt ccatcgagga gaaaccggtc
    27781 cgtccccgct cgccgtacgc ggttcccggc ttctacctct acgacgccga tgtggtcgag
    27841 acggcccggt cgctgcggcc cagcgcccgc ggggagctgg agatcaccga ggtcaaccag
    27901 gcctacctgc ggcgcggcgc actctcggtg acgctgctgg gtcggggcgc ggtctggctc
    27961 gacaccggca ccctggccga ctgcatgcgc gcggtcgact acgtgcgcgc catcgacgag
    28021 ggccagggca tcaagatcgg ctgtgtggag gaggcggcct ggcgggccgg tttcctcgac
    28081 accgcgcagc tgcgtgccct cgccgagccg ttgatgagca gcggctacgg acagtacctg
    28141 ctggctctga ccggcgacgg gctcagccgt accccgcagt ggccggcctt gaccgccgcc
    28201 gccgggtgag cggcccgcgg agggtgaccg gcccgggcgg cgaagggccg gccccccgcg
    28261 aggcgaggaa ccggcccggt ccgtggtcgc cgcagcgccg gtcagcggac tccggtcacc
    28321 gacatgagcc ggccttgcgc atcccgctca gtcacataga actgtccgtc accggagggc
    28381 agggcggccg ccgcctggaa cgccgggtac tgccacagtt ccggtgcctg ccgccgctgc
    28441 ttctcggtga ggccgtcgcg ctgcgcggtc agccggatgc tgcgatagtc gccggcgagg
    28501 tcaccgtcga ccaggcgcag cccaccgttc ggggcgtgca cgaggtcgta gacgcgcccg
    28561 tcggtggctg ccccggccgg ttccagcgtg tcgggcgtac cggtctgcca ggcgatcgtg
    28621 tcccggtcca cccgcaccgc gtcggccctg gtcagatcga gtttcgccgg tttcaccacc
    28681 gacggcagca gccgttcctg gacgcccgcc tgcacccaga cctcccggcc cgcgtcggcg
    28741 aactccagcc gctggtcggt cggcagatcc ttggcctcgc cggcgtgcat gatgtagctg
    28801 agaccggtgg ccccggccgc cagcgggatc cggaagaccg caccgaagct gtcgaacgac
    28861 tccggcagca gcggcgcgcc ccagtcggcg gtgggggtgg ccgcaccgtc ccacaggtgc
    28921 aggccccagc cggtgtaatc gccggctgga cgccggtagt gcaggatcgc ggtgttcggc
    28981 gcgggtgcgg gcgccggacc ctggtaggag atggccgggt cgccctggtg cagccagatc
    29041 ccgggtgtct gctggggatt gagcgagcgg tcggcgtcga cgtccttgac accgttggcg
    29101 tcactcacgg tgaaggtgac cttcgtggcg ccgggccgca gtttgaccca ggcgaacggc
    29161 ccgttaggcg ttccgttccc ggtgaacggc tctccctgcg ggttcgagcg cggccgcttc
    29221 gaacgttcgc cggtggcgtg caggcgccag ccgtcgtagt cgccggcggg acgctgatag
    29281 tgcacgacgg cgtagcccgc ctcggcccgc acggtgccga ccggatccgg ctggtggtgg
    29341 tggcggtacg gcctcggcgt cccgggcgac cgccggtact gcacctcggc gccgccggcc
    29401 agtccggtca ggtcgtggaa cacccggtac gggccccgtc cggccgtgcc gatcggctgc
    29461 cacggcccgt taccggcgcg ggcggagaag gtgacggtgg acagcgggtc gccggtgacg
    29521 gcgcggtcag ttcggtgcgg cccggcacga gggtcccggc ccgcgggtgc ggtgatcgtc
    29581 acggcggggg cgccgtccgc cgcggggatc ggtttctcgg cccgataggc caccgccgac
    29641 agcgccggca cggtgatggt gagccggccg tcggcaccgg tggccgccgt ctcgccggtg
    29701 ccgtagagag gctggaagcc gcagcccggg gtgtaggtgt cgaaggtgac ggtctgcgcg
    29761 gtggtcgcgt tgttcaccgc gatcacatac tcggcacgct ggtcgcggtc gatgcgggag
    29821 gcggcgaaga ccccggcgcg gtcggcggcg taccgggtga tctgctcacc gtcacgcagt
    29881 cccgggtggg ccttgcgcac ggcgcccagc tcggcgatgg tgcggtagag cgggtgcccg
    29941 gtgtcgtggt tgtcgctcgc gtgggtcttg tcggtgccga tcaggcggtc gtccaggtag
    30001 tccggtgtcc ggctggcgaa catgtcctgg cgcgagccct tgttcagccg agggcgcccg
    30061 gtgaagccct gctcgtcggc ccggagtaga ccacccggct ggccgcgggt gaggaacatc
    30121 agctcgttca ccagttcgag ccggcacccg cgtttcggat cggagccggc cttgatcaga
    30181 gtggcgatcc ggcccatgtc gtggttccac tcgccgaggt ggcagccggc cggcgtcggt
    30241 cccggccggc ggctgtagag gtcgtccttc gcgtacaggt cctgccaagg ctgctggccg
    30301 gtgccttgcc cgcgcgcgta gctctgggcc gcgccctgga acgggaagtc gagggtcgcg
    30361 ggcaggccgc cccggcggac gaacgtcgag gtgacttcct ggtccttgct ccaggcctca
    30421 ccgaagagga agaagtcacg cttgcccgcc ttgtccgcgg ccttgcccac gccctcggcg
    30481 aaaggccgcc agaacgccag gtcggtggct ttgagggtgt ccagccggta gccgtcgacg
    30541 ccgaaccgcc ggatccagcc ggcgtagatg tcggtcagcc cgtgcagcac ctcgggccgc
    30601 tcggtccaca gatcgtcgag gccgccggtg aagtcgccgt attcggcgtt ctccccgccg
    30661 aaggtggtct cgccccggtt gtggtacatg gtcgggtcgt tgagccaggc gggtgccttg
    30721 gcggtggcgt cggacggctt ctcgaagaac ggccggtggg ggaacgactt ctcgtcgacc
    30781 ttggggaagc cgtgtgtccc gtcggcgtag ttgcggtcct cgaagggacg acccgcggtg
    30841 tcgcggtagg gcgcggttcc cttgtcggcg taggcggtgc cctcggcgtt cttgatcacg
    30901 tcggcggtgt ggttcaccac gatgtcgagg tagatcttca tgccgcgccg gtgggcgagg
    30961 ccgaccagcc gcttgaggtc ctcgttggtc ccgaagtgcg ggtcgacctg ggtgaagtcg
    31021 gtgatccagt agccgtggta gccggcggac gcgttcggac ccgtaccctg caccggcttg
    31081 ttcttgaaga tcggcgtcag ccagatcgcc gtggtaccga gcccctggat gtagtccagt
    31141 ttgtcgatca cgccctggat gtcgccgccg tggtagaagc cggcgtcggt ggggtcgtac
    31201 ccggtggtga gccggtctcc ggtcagcccg ccctgatcgt tgccggtgtc gccgttggcg
    31261 aaccggtcgg gcatcaccag gtagagctgc tcggcgtggg acggccggtc cggcggcgat
    31321 tcggcctgcg cggcccgcgg agccggcagg ccaccggcgg cccccaccag cacgggcagc
    31381 agcgcccgga cgatatgaga tttcagtctt tcatccatcg tggaccctct ctcgcgatcg
    31441 ctgggacgct agcccggcgg gagacgtgcc cgcaagaact tgctgtttta gcaagaagtt
    31501 tcagaaccgg gacggcacgc tgtagcccag atcatagatc gcgatcaggt agttaaaact
    31561 gcagctcaac ggcaattgcg catggtctga ggtcgatgta cttaaagctc tgcgcaagct
    31621 tagggttgaa gtggcggtga tgcatccatc actgtatgcg catctgaatg acgtcttctg
    31681 caagttcttg cagcggtctc cgggccctgc ccttcctcgt catcccttca caaggagaag
    31741 ctcgtgcaac gtcacgccag gcatgccatc gccgcggcgg tagccgtttc gctgctgccg
    31801 ccgtcactgc cggctcatgc cgccggggct tcggccgtgg tgccgtacgc cggtaacccg
    31861 gccagtctca agcaggacct ctgctaccag atcgccaccg accggttcag cgacgggaac
    31921 ccggcgaaca acaatccggg caacgtgccc ggcatgttcg ccgacaagac caagctgaac
    31981 gaccggcagg agtggctcaa atacatggga ggtgacttcg ccggcatcac ccagcggatg
    32041 gagtacctca agaacctggg cgtcggcgcg atctggatct cgccgcacgt cgacaacatc
    32101 aacgttccgg cgaacggcgc caccggttac cacggctact ggccgcgcga cttcaagcgg
    32161 ctcgaagagc acttcggcac cgacgaggag ttcgacgcgc tggtgtcggc ggcgcacgcc
    32221 agcaacatca aagtgatcat ggactggacg ccgaacggca ccaacccgcc gaaccaggcc
    32281 gaggacggcg ccctctacga cgatgggcag ctggtcggca ggtacggggc ggacagtgcc
    32341 gggcacttcc accacggccc ggcgatcggc gacttcaacg atcgctacca ggaccagtac
    32401 tacagcctgg ccgacatcgc cgacctcgac cagcagaacc cgcgggtcga ccagctgctc
    32461 aaggacgacg ccaactactg gatggaccgc ggggtcgacg gcatccgggt cgacgccgtc
    32521 aagcacatgc cgctgagctg gcagcggtcc ttcgccgacg cggtcacctc gcacaagagc
    32581 gcggccatct tcggcgagtg gtacatgggc gaccagtccg atccgctcta cgccgaccag
    32641 gtcaagttcg ccaacaccag cggcatcgcg gccatggact tctacaccaa ccgctcgatc
    32701 cgcgacacct tcgccggcgc cggctcgatg aagtccctgg acgcggcgat caccaagacc
    32761 aaccgggact acctctacga gcaggatctg atcacgttcc tggacaacca ggacacccgg
    32821 cgcttcggga cgctcaacag cgatccggcg gccctgcacc gggcgctcgc cttcctgctc
    32881 accacccggg gtacgccgtg cctgttctac ggcaccgagc agtacctgca caacgacacc
    32941 ggtgagggca gcaacaaggg caaggacccg tacaaccggc ccccgatggc cagtttcgac
    33001 accgacacgg tcgcctaccg ggagatccgc gccctctccg acctgcgccg gtcgaacccc
    33061 gcggtggcct acggggacca ccagcagcgg tggatcaacg acgacgtgta cgtctacgag
    33121 cgccggttcg gcgacaacgt gctgctgacc gccatcaaca agggctcgca cgagtaccgg
    33181 ctcgacgggc tgcgcaccgc gctgccggcc ggcacctatc gcgacgtgct cggcggcacc
    33241 ttcggcggct ccgacctgac cgtcgaggac ggcgacggca ccgaccggtc gaccgtcgcg
    33301 ccggtgctgg gtgccgggca ggtcgccgtc tggtcgtacc gggcgccggt ggacaccgag
    33361 ccccggatcg gcggggtcgg gccggtcgtg acccgggccg gcgccaccgt caccgtcgag
    33421 ggcaccggct tcggctccgg cggaaccgtc gcgatcggcg gagtccccgc gaccgtccag
    33481 cagtggacgg cggaccgtat caccgccacc gtcccggtcg gcgttcccac cggggccgtc
    33541 caggtgaccg tcggcaacgg ctccggcacc agcaacgggt acccgatcac cacccgtacc
    33601 ggaaaaccgg tcccggtgca gttcaccgtt cagaacccgc cggccaccgc gcccggggag
    33661 tcgctctacc tgaccggtga cgtcgccgag ttggggcact ggtcgaccag cccggaccag
    33721 accgcgggac agctgctgcg ggtgccgaac gagtcccggg gcgtcctcgt cgccgacctg
    33781 ccggccgggg cgccggtcga gttcaagttc gtcaaggtcg cggccgacgg cacggtgacc
    33841 tgggagggtg gtgccaacca ccggtacacc gtcccggccg gcggcaccgg cacgaccacg
    33901 ctcacctggc agcgctgacg ccaccgtgcg gagggcccgg ccgtgaccgg gcccgccgca
    33961 ccgggccggg cggtggaacg gccgggacgg tgggcgccgg ccccggcgtg cgcagatcga
    34021 gggctgcgca caccgggggc tgaacggctg gtctggccca gcgccgacgg tccgccgtcg
    34081 gcgagtatct caccttcagg gcgtccccgg acgcctcgcc cggcttctcc accagcgccg
    34141 acggttacca gatcacccct tggtggagcc gagggagagg ccggcgatga actgcttctg
    34201 caggagcagg tagaccacca gggtggggat ggcggcgatc agggccgcgg cggcgatcag
    34261 gttctggttc gagacgaact ggccctgcag gttggccagg gcggaggtga tcgggcggcg
    34321 gtcacccgtg gagatcaggg tgatggccca gaagaagtcg ttgtagatcc acgtggtgag
    34381 cagggtggcc agggcggcca gggccgggcg gcacaggggc atcgtcaggc gccagtaacg
    34441 cgaccacagc gtggcgccgt cgatcagggc cgcctcgtcg atggcggggg gcagggtctt
    34501 catgtaattc gacaggacga agacgcagaa gcccagctgg aacgagacgt tgatcaaaat
    34561 caggccggcg tacgagttgt acagcaggcc gcttccactc agccaggacg gcaggtggac
    34621 ggccaggtag atgcggtaca gcggggtgat gatgacctgc tgggggagca ggttgccggc
    34681 ggtgaacagg atcagcagcg gaatgttgaa ccggaaaccg aggcgggaca acacgtacgc
    34741 cgccatggag gccagcaaca gggtgatcag cacggccggc acggtgacat agacggaatt
    34801 gagaaagaat cgccacatgc cggatcgggt ccacgcatgc gcgaagttgg acagggtcat
    34861 ctggtgcggc agtgacacgt accctgactg attggtctct tcgatcggtc gtaacgcgac
    34921 gtacagcgcg aaaacgatcg gcatcagcca caacaccgcc atgaccagca ggaagagctg
    34981 cgatccggta cgtttcaccg ttcctcccgc cggaatgcct gccacaggaa aagggagatc
    35041 ggcaccagcg agatgaccag cagcaccacg cccagcgtgg agccgaagcc gatccgctgg
    35101 gtttccccga cgatgttctg ggtgaccgcc acggacagca gttcgaggcc gcgcagcgga
    35161 ttgccgttgc tggtgatgta gaccaggtcg aaggcccgca acgactcgat gaccgtcacg
    35221 accagcacca cgatgttgat cggtcgcatc gccgggaaga cgacccgcca gaatgtctgc
    35281 cacgcgttcg cgccgtccac gatcgccgcc tcgcgcagcg ccggatcgac cgctttcaaa
    35341 cccgccagat acagcaccat cacgtacggg gcctgccgcc agctcgcctc gacgagcagc
    35401 gcccagaggt tgagccgggg attgccgagc cagtcgatca ggttgtcgtt gtggttgtgc
    35461 ccgagcaccg tgttgatcag cccgaagttg ggggagtaga tgagctccca gatgatgccg
    35521 atcagcgcga gcgacagcat caccggcagg aacagcacgc tctggtagaa ccggctgccc
    35581 cgcaccccgc ggtcgatcac caccgcgaac agcatgccca gcggcgtcgc gaggaggatg
    35641 aagaccacga gccagatggc gttgtgccgg accgccggcc agaagtccgg ataattggtg
    35701 aacgcctggc gataattgtc gacgccgttc aggcaacccg gttgcgggat gccgggcgcg
    35761 gacgggaaat ccgcgcagga ccgcatccgg atcgagccga tcccggtcca tttggtgaag
    35821 gacagcagca cggaggcgag cgccgggaac cagatgaagg cgaggtcgag cagtagcggc
    35881 acgccgagca tggcggcggc gaccgcgacg tcgcggcggg tgagcgtgcg gcggcgccgg
    35941 cgggcggccg gcgccggtcg aatggtcggg gtcatcagcg gaaaatcgtc ttcgcctggt
    36001 cctcagcgct cttctgaacg gtcgcgatcg tctccggggt cggctggtcg atgaactgct
    36061 ggatcagctt gatcatcgcg ttggccatgt cgggcacggt gtcgcggtcc atgaactgcg
    36121 agacgctctt gcatttgccg atctcggcga ccgacttctt ctggatgtcg ttgtaggtgg
    36181 gtgcgatcag cccgttggcc aggccgacgt cccagtggtc ggtcttgagg aacgcggcct
    36241 cggcctcggc ggtgccgatg tattgcagga ccttcttggc cgcggcggcg ttcttcccct
    36301 tcttcggcag gatgaagccg tcggtgggtg cgtccatgta gtcggtgccg tactgcgggt
    36361 tgatcgccgg gaagacgaag aagtccaggt cgggaaggtt cttcgcgctg tagttggcgg
    36421 ccacctggtt ggagccctgg aacatcatcc cggcctgctt gttctccaga gctttggcgg
    36481 cgtcctgcca ggtccggccg ttggcgccct tctgctggta cgcggccagt tcccgccact
    36541 ggtcgaagac cttggtgacc ccggggtcgg tccacggcac ctcgtgcttc atcagcttga
    36601 tgtggtagtc gtagccgttg atccgcaggt tgaggatgtc gaaggtgccc agcgccggcc
    36661 agccgtcctt gtcggcgaag gccagcggga ccagtccgtc cgactgcatc ttccgggcca
    36721 gcgcgatgaa cgcctcccag ctggccggga cctcgtaccc cttggactgg aaaacgctct
    36781 tgttgtagaa gacgacccac gggtagttgt agagcggcac caggtagtag tggccgtcga
    36841 gtcctttgga gaggcttttc gcggcgtcgt tgaaggtgcc gccgatcttg tcccagacgt
    36901 cgtcgatcgg ggtgagcagc ccctgcgcgg cgaagaactg caggcggtac ccggcgaacc
    36961 aggtggccag cgagtccggg gtgccctgca ggtaattgct gatgttgttc tggaacgtgt
    37021 tgtggtccgt ggtgttgacc gtgaccggga cggtggtgct ggtggtcgcc tgctgcatca
    37081 gcgacgcgaa ggccgccttg ggcgcctcgt cggagtagtt ggagccgaac gtgatcggcc
    37141 cgttgccgtc gctgacgctg gtcgtcccgc tcttgtcgtc actgccgcag gcggcgagca
    37201 gggtggcggt cgcggcggcg ccggtgagtc ctatcaggga ccgccgggtc aggccggcgg
    37261 agtcgaaacg tgtcatgggt cgccctccga gctagcggaa acgcacacag tccaacgtga
    37321 ctggccgtca tcgaactctg tcggacggtc gatgtcaaga catccgattg ttactgcctg
    37381 attgcggaaa gatcgtggct cgctggttgc ggggatggcc agggatagtt catgccttac
    37441 agggacatcg acgctgacgg atgcgttgac ccaagatccg acattgtcgc gcgtaatcac
    37501 acgcagggga gtggcacatg cgtcacttgc tcatggtcgc ggtcaccgcg gccgccatcg
    37561 gcaccctcgc cgcacccgcc ccggccgccg cggccaccac cgtcgccctc aacggcggca
    37621 tcgtcggccg cgccttcgac ggcgtcggcg cgatcagcgg tggcggcggc aactcccggc
    37681 tgctcatcga ctacccggaa ccgcagcgcg ggcagatcct cgactacctg ttcaagccgg
    37741 gctacggcgc cgcggtccag ctgctcaaac tggagatcgg cggcgacgcc aactccaccg
    37801 acggctccga gcccagccac cagcacgtac gcggcgacat caactgcaac gccggctacg
    37861 aattctggct cggcgagcag gcggtcgccc gcaaccccgg gatccggctg gtcgccctgc
    37921 cgtgggccgc gcccggctgg atcggcggcg gttccttctg gtccacggac atgatcaatt
    37981 acgacgtctc ctggctcaac tgcgccagac agtacggcct gacgatcagc tacctgggcg
    38041 gctggaacga acgcggccac gacagcacct ggtacaagaa cctgcggacc gggctcgaca
    38101 acgccggata ctccgcggtg cagatcgtcg gcgacgacag cggctggggg atggccgacg
    38161 agttcgccgc cgaccccacg ttgaaaaacg cggtcggcgt gctcggcaac cactacgtct
    38221 gcggctatct gtcccaggcc gactcgtgca gcaccacggg caacgcgcgc tccagcggga
    38281 aaccactgtg ggccagcgaa ttcggctccc aggacgacaa cgcgggcgtg gtgccgtaca
    38341 tccgtaccgt caaccggggt tacctcgacg cggagatcag cggatacatg aactggccgc
    38401 tgatcgcggc catcaccccc aatctgccgt tcgccacggt gggcctgatg gatgccggct
    38461 caccgtggtc gggggcctat cgggtgggcc ggaatctgtg ggcgaacgcg cattacgccc
    38521 agttcaccca gcccggctgg cactatctca acagttcggc cagcggatac ctgggcggga
    38581 accgggccaa cggcagctat gtgacgctca aatcgacgaa caacaccgac tacagcacca
    38641 tctacgagac cagtggcagc accgcggcgc aaaccgtgaa cgtcaccgtc tccggtgggc
    38701 tcagcaccgg caccgttcac gtgtggtcga ccgacatggg ctcgtcgaat tccgccgact
    38761 ggttcgtccg gcaggccgac atcacgccgg tcggcgcgac gtacaccctc aatctgcagc
    38821 cgaatcggat ctataccgtc accacgacca ccgggcaggg gaaaggcacc gcggcgggtc
    38881 cggctccgca tggtctggcc ctgccgtaca gcgacaattt cgacggatat gcggtccgta
    38941 agctgcccca ctacagcgag gacatgcagg ggtcgttcga aacccgggcc tgctcggccg
    39001 ggcgcggcgg gacgtgcctg cagcaggtcg cgccgctgcg gccgatcaat tggcaggacg
    39061 acagcgacgc cttcaccctt ttcggcgaca ccggctggac caattacacg gtcagcctcg
    39121 acgtgaacat gcagcaggcc ggcaccgtca cgctgctggg ccgggccaac atccagaacc
    39181 gtccgcagaa ccggcaggcc gcctatcagc tgcgcgtcac cgacaacggc ggctggtcga
    39241 tcgtcaaaca caccaatgcc gacacggaca cgacgctcgt ctccggcacc cgcgccgcgc
    39301 tgggcctgaa cagctggcac aatctacgac tcggattctc cggcggccag atcaccgccg
    39361 ccatcgacaa caccacggtg ggcaccgtca ccgactatgc gtacggcgcg gggcaggccg
    39421 gcgtcggcgt cgtcggctac cagaccgacc agttcgacaa cctcagcgtc acccccaaca
    39481 gcggcccggc cctcaacacg ctgcgtggcg tcgaatccgg ccgctgtgcc gacgtgcccg
    39541 gcgccagcca gaccaacggc acccagctcg ccctctggga ctgcaacggc ggcagcaatc
    39601 agaacttcac cctgacagat cagaaacaat tgctggtgta cgggtcgaag tgcctggacg
    39661 tcaacgccgg aggaaccgcg gacggcgcca aggtgcagat ctgggattgc cacggcggaa
    39721 ccaaccagca gtggacgctc aacgccgacg gcacgatcgt cggaatcggc tccggcaaat
    39781 gcctggacgc caccggccac ggcacggcca acggcaccct gctcgaaatc tggacctgca
    39841 acggcggcga caaccagaag tggagccggt catgaaacgt ctcgcggccc tgctgtcgat
    39901 cggcattctc ggcctggcgc tcgccgcccc ggcgcaggcg gcggaatcca acggcggcgt
    39961 ccgggtgatg ccactgggcg actccatcac cgacggctac aacgtgcccg gcggctaccg
    40021 catcggactg tggcagcgcc tggccgccga cggccacctc accgacctcg tcggctccgg
    40081 ctccaacggc ccggccggcc tcggcgacca cgaccacgag ggccaccccg gctggcgcat
    40141 cgaccagctc gacgccgcca tcgtcggctg gatccagcag gccgacccgc gtaccatcct
    40201 gctgcacatc ggcacgaacg acatcggcca gaactacgac gtcgccaacg ccccggcccg
    40261 gctctccgcc ctgatcgaca agatccgcgt caacgcgccg caggtgcagc tgttcgtcgc
    40321 gcagatcatc ccgaccgcca acgcggcgaa cgagcagaag acccagacct tcaacgcggc
    40381 cctgcccggc atcgtcgccc agaagggccc gctcacccac ctggtcgacc agcactccgc
    40441 actcaccacc gccgacctgg ccgacggcgt gcacccgaac gccgccggct acgacaggat
    40501 ggccgcccgc tggtacgccg ccctgcaatc ggtgcccggc agcctgacca ccctcaccac
    40561 cccgccggtc ggggcgaccg tgctgctgtc caacccgcag tcgagacgct gcctggacgt
    40621 cggcaccacg gtctccctct gggactgcca cggcgcggcc aaccagcagt gggtccgcac
    40681 cgccgccggc gaactccgca acggcgccga ctgcctggac gcgaccggcg ccggcaccgc
    40741 gaacggcacc aggctgatca tctggccctg ccacggcggc gccaaccagc acttcacctt
    40801 ccaccccgac ggcaccatcg tcggcgtgcc ctccggccgc tgcgtcgacc tcaacgccaa
    40861 cggcaccgcg aacggcacga tcgtccaact gtgggactgc aaccggggcg ccaaccaggt
    40921 gtggtccgcc cgctgaccgg ccccgtgacc ccggtcgtga tctccggggt tccgggcgcg
    40981 ggaagtgatc ggcccggcgc tcgccggccg ggccgggaca agaccggtcg cagcatgctg
    41041 cgaccggtgc gggcgtgcgg cagatcgccc gtcatccggc cgggatcaat cacgggagga
    41101 ggcagcgcag cgccgcccgg tccgcggagt gcggcggcga tcgcctccgc cggagtcgtc
    41161 gtcggccgtc cgatcaggcg ccgcaggtcg ccggagtcgg tgaacatctc gtcgtggctc
    41221 atggcgcggt cggcgtccgc aaggacctgc gccagctcgg tgggcacgcc cgcgccgacc
    41281 agcacccggg cgaacgcgtc gaccggcaga tccgatatct cta
//
