BGC0000692: apramycin biosynthetic gene cluster from Streptoalloteichus hindustanus
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Location: 1 - 39,979 nt. (total: 39,979 nt).
This entry is originally from NCBI GenBank AJ875019.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000692
Short description apramycin biosynthetic gene cluster from Streptoalloteichus hindustanus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ875019.1
via
Compounds
  • apramycin
Species Streptoalloteichus hindustanus [taxonomy]
References
Chemical products information
apramycin Evidence:
Copy SMILES
C21H41N5O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ShinN01.1c
  • CAI47636.1
  • aprN
 1 - 516 (-) putative aminoglycoside N-acetylhexosaminyl deacetylase
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    • ShinN01.2c
    • CAI47637.1
    • aprW
    		 632 - 2512 (-) putative ABC-type aminoglycoside exporter
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      • ShinN01.3c
      • CAI47638.1
      • aprV
      		 2509 - 4311 (-) putative ABC-type aminoglycoside exporter
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        • ShinN01.4
        • CAI47639.1
        • aprU
        		 4608 - 5618 (+) putative apramycin kinase
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          • ShinN01.5
          • CAI47640.1
          • aprA
          		 7080 - 8207 (+)
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            • ShinN01.6
            • CAI47641.1
            • kamB
            		 8483 - 8950 (+) 16S rRNA methyltransferase
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              • ShinN01.7c
              • CAI47642.1
              • aprO
              		 8940 - 11282 (-) putative phosphorylase or hydrolase
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                • ShinN01.8c
                • CAI47643.1
                • aprD1
                		 11279 - 12217 (-) putative tobramycin/apramycin biosynthetic oxidoreductase
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                  • ShinN01.9c
                  • CAI47644.1
                  • aprF
                  		 12233 - 13510 (-) putative apramycin biosynthesis protein
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                    • ShinN01.10c
                    • CAI47645.1
                    • aprG
                    		 13507 - 14403 (-) putative apramycin biosynthesis protein
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                      • ShinN01.11
                      • CAI47646.1
                      • aprH
                      		 15344 - 16420 (+) putative glycosyltransferase
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                        • ShinN01.12
                        • CAI47647.1
                        • aprI
                        		 16508 - 17296 (+) putative N-methyltransferase
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                          • ShinN01.13c
                          • CAI47648.1
                          • aprJ
                          		 17405 - 18118 (-) putative phosphosugar mutase
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                            • ShinN01.14c
                            • CAI47649.1
                            • aprK
                            		 18122 - 18613 (-) putative NDP-octose synthase
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                              • ShinN01.15c
                              • CAI47650.1
                              • aprM
                              		 18671 - 20080 (-) putative glycosyltransferase
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                                • ShinN01.16c
                                • CAI47651.1
                                • aprC
                                		 20084 - 21244 (-) putative 2-deoxy-scyllo-inosose synthase
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                                  • ShinN01.17c
                                  • CAI47652.1
                                  • aprS
                                  		 21278 - 22552 (-) putative ketocyclitol aminotransferase
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                                    • ShinN01.18c
                                    • CAI47653.1
                                    • aprE
                                    		 22658 - 23674 (-) putative 3-amino-2,3-dideoxy-scyllo-inositol 1 dehydrogenase
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                                      • ShinN01.19c
                                      • CAI47654.1
                                      • aprP
                                      		 23779 - 24597 (-) putative amidohydrolase
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                                        • ShinN01.20c
                                        • CAI47655.1
                                        • aprD2
                                        		 24594 - 25556 (-) putative tobramycin/apramycin oxidoreductase
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                                          • ShinN01.21c
                                          • CAI47656.1
                                          • aprD3
                                          		 25814 - 26560 (-) putative tobramycin/apramycin oxidoreductase 3
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                                            • ShinN01.22
                                            • CAI47657.1
                                            • aprQ
                                            		 27767 - 29278 (+) putative hexosamine-6-dehydrogenase
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                                              • ShinN01.23
                                              • CAI47658.1
                                              • aprD4
                                              		 29339 - 30709 (+) putative Fe-S oxidoreductase 4
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                                                • ShinN01.24
                                                • CAI47659.1
                                                • aprZ
                                                		 30734 - 32134 (+) putative 6-phosphate phosphatase
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                                                  • ShinN01.25
                                                  • CAI47660.1
                                                  • aprL
                                                  		 32251 - 33372 (+) putative aminotransferase
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                                                    • ShinN01.26
                                                    • CAI47661.1
                                                    • aprD5
                                                    		 33425 - 34462 (+) putative epimerase/dehydratase
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                                                      • ShinN01.27
                                                      • CAI47662.1
                                                      • N01.27
                                                      		 35325 - 36674 (+) putative phenylacetyl-CoA ligase
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                                                        • ShinN01.28c
                                                        • CAI47663.1
                                                        • N01.28c
                                                        		 36760 - 37563 (-) putative membrane protein
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                                                          • ShinN01.29c
                                                          • CAI47664.1
                                                          • N01.29c
                                                          		 37578 - 38120 (-) putative membrane protein
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                                                            • ShinN01.30
                                                            • CAI47665.1
                                                            • N01.30
                                                            		 38333 - 39052 (+) putative membrane protein
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                                                              • ShinN01.31
                                                              • CAI47666.1
                                                              • N01.31
                                                              		 39281 - >39979 (+) putative glutamyl endopeptidase precursor
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                                                                Biosynthesis information
                                                                Annotation changelog

                                                                Entry version: 4

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-10-07
                                                                Update chemical activity to schema version 2.11
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Updated bioactivity data
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                2019-10-16
                                                                Updated reference publication(s) (MIBiG Annotathon)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2015-06-12
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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