LOCUS       BGC0000694             19248 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Bacillus circulans genomic region of the butirosin biosynthetic gene
            cluster, strain ATCC 21557.
ACCESSION   BGC0000694
VERSION     BGC0000694
KEYWORDS    .
SOURCE      Niallia circulans
  ORGANISM  Niallia circulans
            Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Niallia.
COMMENT     Related sequence: AB066276.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:18:04
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            <1..777
                     /gene="btrM"
     CDS             <1..777
                     /codon_start=1
                     /db_xref="GOA:Q2L4I5"
                     /db_xref="InterPro:IPR001296"
                     /db_xref="UniProtKB/TrEMBL:Q2L4I5"
                     /gene="btrM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 152.8;
                     E-value: 2.5e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="paromamine synthase"
                     /protein_id="CAG77417.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.4e-40,
                     bitscore: 128.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="DQFVHDFVKSVELKSIKLSHKAVVLTDKRLDSYNRLLEDSSKMTA
                     ISDCIGSNHLSHSIDCPFCSRLKTELLGKKTVLFLGRIAHEKGWSTFVSVAKELADKIG
                     DLQFIVCGDGPQREAMEEQIKAANLQNQFRITGFISHKFVSCYLHHAQLFLLPSHHEEF
                     GGSLIEAAIAGVPIISTNNGGPADIFTHGETAILKDPGDVSGIADEAYKILTNDSVAES
                     LRLHSRPEVVSKFLPHCVYPNYLNLYSSKEAAVHEG"
     source          1..19248
                     /db_xref="taxon:1397"
                     /mol_type="genomic DNA"
                     /organism="Niallia circulans"
                     /strain="ATCC 21557"
     subregion       1..19248
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000694"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19248
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="((DOIS or DHQ_synthase or ValA or salQ) or strH or
                     strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..18753
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[766:8753]"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ) or
                     strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      767..8753
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ) or
                     strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     cand_cluster    1..18753
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((DOIS or DHQ_synthase or ValA or salQ)
                     or strH or strK1 or strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     gene            767..2581
                     /gene="btrL"
     CDS             767..2581
                     /codon_start=1
                     /db_xref="InterPro:IPR002110"
                     /db_xref="UniProtKB/TrEMBL:Q4H4F7"
                     /gene="btrL"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: NeoL"
                     /gene_kind="biosynthetic"
                     /product="putative biosynthetic protein"
                     /protein_id="CAG77418.1"
                     /sec_met_domain="NeoL (E-value: 2.3e-171, bitscore: 560.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDNPISLFHELESYVRGSKDTLHRYMYACILEQRLADLLLLSRC
                     GVHPDDEDRLAVRLASQRSLCVQAASDLAEGTEEARGSTPAWPDCKVTKSSAAQKRPEL
                     LSLVKVMQELRTPECSGYDLCDLEVCREDALHWLRDHADPSSPPVLIGVRTGGAFYAPL
                     WSSALQQRWGNKALYHTVRALRMPSDPGASLYLPEELSILPAAIEPDTDIVILEDQPHT
                     GGTVLELAGRLSAKYRLNKPVWVSSPGRLFQIENGRLAKCSDRIPLNTGTRKRIWQMLG
                     NSEEVAEFLLPKLGLTDAHPADLEAVPYKSVPQWNDPMYRREVPFRINPKKTPFYIRRK
                     STNEPVVFAKFIGKDLFGDFQFHQLKKFEKYFPDILAYQDGYVMTKYEPGLKEMREMFV
                     NMPSAVTREICQSVSGYWKTLLDSCQISGGHPVHPLADHWQARLGEMEDFIGRKLPYDL
                     DWFERSLHTEWTSSAHVYTSLPYANQYGHWKARLSAGQRLKTYRFHIDSTWGGTSSIEV
                     ELASFLLENRVRPDDFRLLVNQVKKEAGSLTIEAVTDALPIACVLQAANLLKQAKDESR
                     LSKELILSEAMQSFEYLQAMKPKLSDVR"
     gene            2628..6305
                     /gene="btrA"
     CDS             2628..6305
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q4H4F6"
                     /gene="btrA"
                     /product="hypothetical protein"
                     /protein_id="CAG77419.1"
                     /transl_table=11
                     /translation="MNSFGIKCERLLELRNNETFTAHIPPLYPIDPKPAVEFLEQYSGT
                     EEELPGRLARYLEQREPSRFDQIKKVCGDLPWIIRSSGEEDLNETTNAGAYLSLVCEHR
                     DNFYEVLAQVMLSGSTEHARNQNRRFVSRDLHDHEPIPVFVQPLVQSEHPGHPVPYDAT
                     PYVRKEDLQTIIGLLKNLHSTMPDYALDCEWVGDSDFGTISMTSLTELADGKLTGQIAF
                     GFDLFSTQHVKANNSVRYLLPGDELNLWQGHIFQEVNMQSLFLVQTRPAKNYRLFQHVY
                     ELSASSKKELEKDAALCLDAKEFISQGGKPFFGKFIKAVTLNEAWNAYLQYTGKDVKED
                     IAAILVEFGTRTEHAGIMFNQVGIPVIRIEIALIPESMTYIVLDPFSLQCRLYSHNKEV
                     KALEYETREIIPLPDNCILVQDREGKHQQREAMAVSADEYFNEVLNKPFFSEKTKEHLT
                     ANSAYPAYSFIFHGKDDARSPSYYANDAERLTAETVDDFLKSREWPEASANYFLALFHA
                     KNLLKDGNIAAYVGRQPDDRGRSNETLVYWKVLRIHHLLAKCSSRDRDTLLERVRAEMS
                     VNSAVIELRLDVLFLFEQYLDALCIYSKREEEALIQSFIGILSSVKDEDLPVVLDLARN
                     GIFNAGHLCQFLKHAIENRHLFDLYRNYSLVGKEFAIIPYDLSVVSRFPYFNEVFVDLN
                     NEMNKYESLGELSSSIFHTVVETYDKSAKEILLSVIDDGSPSYYQAYLRLLTEWLGLIR
                     QFDKNEKVIQTFLDWIGVQEDRQAEIEDYFLEEIHWKTRIEEAEAGTAEDLSLTNLHQL
                     HNVLHQWSLHLVPASNGAHMPLFVKEMVAFAQSFSEQENRLLRMQKDFFEIELAMCTHK
                     AGFMFYKHSVTVEFSEPPSVHDDEIARLSAFASFMNKCNDWFEAYRFRTHYEKVAGTWT
                     CYMTVKSVEDGALQQSDYKTIFHIIRFVLDSSYDFSHNPLSAVEDLSAQLNEPEWKDIF
                     RKLVNYRVHFDDEGQFINLKLFAMSTFFTYLCLSPSLRSRLLSLYRDGFDRMVGELAVL
                     EDGMARAGHYSEWLEHYESATYTALFLAAIYPLETVGKLESLRDRRLTYDIVARNLLKH
                     KDAANKVIETLPTWDKALQSSMTDKLLHYCPAKFFKTVSSVNEVAKELSKRSKSFKRAK
                     QVLLNAYADSLEPDLLRQFIDDLQYVPYAGTEAQNQQLDKYLTDSGKKRYDIQKEILYI
                     "
     gene            6346..7644
                     /gene="btrB"
     CDS             6346..7644
                     /NRPS_PKS="Domain: Aminotran_3 (34-314). E-value: 1e-14.
                     Score: 46.1. Matches aSDomain:
                     nrpspksdomains_btrB_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GOA:Q4H4F5"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="UniProtKB/TrEMBL:Q4H4F5"
                     /gene="btrB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 225.7;
                     E-value: 1.6e-68)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative hexosaminyl-6'-aminotransferase"
                     /protein_id="CAG77420.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3e-16, bitscore:
                     49.1, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKQETVKSSEQLLSVLGTYIDSPVDPFRKERVMFSRGSGAYLFDY
                     DGGNYIDLMNGKGSIILGHNDPSVNAALRNFLEQDREVVTGPSKPIIDLAERIKKDSAL
                     PDAKVSFYTTGTAACRAAVYAARDYSGKKIVLSSGYHGWDPMWRQQGPLLEPNEDGVIE
                     FYFIPELLERALTAHKDQVALVIFSPDYTYLSASTMERILGICRAHGVLVCCDDVKQGY
                     RHRQGSSLELVTTEKADMYVFSKGLSNGHRISCVVSSDEIMAETKEHTYTAYYQMLPIL
                     SSLETLKKMESGKGYDLIRSYGQTLTGNLKELFVQSSLPIEVNGSSIFQLVFGDEELEE
                     AFYREAFIQGLILFEGDNQSLSLCMDKDVQVDLIRRFANVTDVLSEQFKHLRGKEVTTE
                     QTFRTAWNMIDGASDLLPYEKQLKLLDNLIGGG"
     aSDomain        6448..7287
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_btrB_Aminotran_3.1"
                     /evalue="1.00E-14"
                     /label="btrB_Aminotran_3.1"
                     /locus_tag="btrB"
                     /protein_end="314"
                     /protein_start="34"
                     /score="46.1"
                     /tool="antismash"
                     /translation="SRGSGAYLFDYDGGNYIDLMNGKGSIILGHNDPSVNAALRNFLEQ
                     DREVVTGPSKPIIDLAERIKKDSALPDAKVSFYTTGTAACRAAVYAARDYSGKKIVLSS
                     GYHGWDPMWRQQGPLLEPNEDGVIEFYFIPELLERALTAHKDQVALVIFSPDYTYLSAS
                     TMERILGICRAHGVLVCCDDVKQGYRHRQGSSLELVTTEKADMYVFSKGLSNGHRISCV
                     VSSDEIMAETKEHTYTAYYQMLPILSSLETLKKMESGKGYDLIRSYGQTLTGNLKELF"
     gene            7647..8753
                     /gene="btrC"
     CDS             7647..8753
                     /codon_start=1
                     /db_xref="GOA:Q9S5E2"
                     /db_xref="InterPro:IPR001969"
                     /db_xref="InterPro:IPR002658"
                     /db_xref="UniProtKB/Swiss-Prot:Q9S5E2"
                     /gene="btrC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: DHQ_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: DOIS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 303.1; E-value:
                     3.7e-92)"
                     /gene_kind="biosynthetic"
                     /product="2-deoxy-scyllo-inosose synthase"
                     /protein_id="CAG77421.1"
                     /sec_met_domain="DOIS (E-value: 1.4e-153, bitscore: 501.0,
                     seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 6.3e-69, bitscore:
                     222.1, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKQICFADRCFNFAFGEHVLESVESYIPRDEFDQYIMISDSGV
                     PDSIVHYAAEYFGKLAPVHILRFQGGEEYKTLSTVTNLQERAIALGANRRTAIVAVGGG
                     LTGNVAGVAAGMMFRGIALIHVPTTFLAASDSVLSIKQAVNLTSGKNLVGFYYPPRFVF
                     ADTRILSESPPRQVKAGMCELVKNMLILENDNKEFTEDDLNSANVYSPKQLETFINFCI
                     SAKMSVLSEDIYEKKKGLIFEYGHTIGHAIELAEQGGITHGEAIAVGMIYAAKIANRMN
                     LMPEHDVSAHYWLLNKIGALQDIPLKSDPDSIFHYLIHDNKRGYIKLDEDNLGMILLSG
                     VGKPAMYNQTLLTPVRKTLIKEVIREGL"
     gene            8756..9583
                     /gene="btrD"
     CDS             8756..9583
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q4H4F3"
                     /gene="btrD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PIG-L"
                     /gene_kind="biosynthetic-additional"
                     /product="hypothetical protein"
                     /protein_id="CAG77422.1"
                     /sec_met_domain="PIG-L (E-value: 1.9e-21, bitscore: 67.2,
                     seeds: 137, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQDKRAFMFISPHFDDVILSCASTLMELMNQGHTCKVLTVFGGC
                     PSVRFQPGEIARQYAAEDLGLFEDEIEGDHLSILVARRLQEDQQAFRHLPGVQVEVLSF
                     PDAIYRENKGQPYYRTEADLFGIPDKQDEDIFLPKIETYLQSCDLARKYTWVFPAISKH
                     VDHRLLTKAGLRLMSQGYPVLFYSEFPYWQQHNEFLQDGWRQLELRNSVYTPVKRAAVL
                     EYKTQLLGLFGEEAETKINNGGVLSEAELFWIQETDTQAWRVFRSLSPEPLQT"
     gene            9607..10656
                     /gene="btrE"
     CDS             9607..10656
                     /NRPS_PKS="Domain: PKS_ER (17-236). E-value: 2.9e-18.
                     Score: 57.8. Matches aSDomain:
                     nrpspksdomains_btrE_PKS_ER.1"
                     /codon_start=1
                     /db_xref="GOA:Q4H4F2"
                     /db_xref="InterPro:IPR002085"
                     /db_xref="InterPro:IPR011032"
                     /db_xref="InterPro:IPR013149"
                     /db_xref="UniProtKB/TrEMBL:Q4H4F2"
                     /gene="btrE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 124; E-value:
                     1e-37)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 3-amino-2,3-dideoxy-scyllo-inositol
                     1-dehydrogenase"
                     /protein_id="CAG77423.1"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.4e-26, bitscore:
                     83.1, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEILTYTGPSRLIVETAEELPLKSGECRIQSLYSGISHGTEMGAY
                     RGIAPYFTRDMDSETRLFEDLAEEHKVKYPIRSCEDDAWFIGYSNVGKIIEVGAEVEGF
                     TVGDIVFSHGRHQTIVCKHHKKIFKLPQKLEPELGIFYTNLMTAYNAVLDTRIKIGDVV
                     VVSGLGVVGQLIAQLAKLSGATVVGVDPLENRLNIAREVEIDYVFNPNRTDVAKEIREI
                     TNNRGADAVFEVSGHSTALNQAIRIAAPDTVITAVGWYQGGQSVLNLSEEFHQNRITIR
                     ASQTLGIDPSISHMYDDARRRNIGKDLLLKLKLRNLISHRIPFGDAPKAYEMIDKHPHE
                     VLQVVLTYS"
     aSDomain        9658..10314
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_btrE_PKS_ER.1"
                     /evalue="2.90E-18"
                     /label="btrE_PKS_ER.1"
                     /locus_tag="btrE"
                     /protein_end="236"
                     /protein_start="17"
                     /score="57.8"
                     /tool="antismash"
                     /translation="EELPLKSGECRIQSLYSGISHGTEMGAYRGIAPYFTRDMDSETRL
                     FEDLAEEHKVKYPIRSCEDDAWFIGYSNVGKIIEVGAEVEGFTVGDIVFSHGRHQTIVC
                     KHHKKIFKLPQKLEPELGIFYTNLMTAYNAVLDTRIKIGDVVVVSGLGVVGQLIAQLAK
                     LSGATVVGVDPLENRLNIAREVEIDYVFNPNRTDVAKEIREITNNRGADAVFEVSG"
     gene            10668..11366
                     /gene="btrF"
     CDS             10668..11366
                     /codon_start=1
                     /db_xref="GOA:Q4H4F1"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="UniProtKB/TrEMBL:Q4H4F1"
                     /gene="btrF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     153; E-value: 1.7e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative oxidoreductase"
                     /protein_id="CAG77424.1"
                     /transl_table=11
                     /translation="MIVFITGANRGLGLSLCEVFLERGHQVLAGVRNMNRAGQLLPLKT
                     KYKEELSIIPVDVSSQDSIRQAYSLITAVTPKLDAIINNAAREGIRCKKIQEVDIADFE
                     ETWKTNVLGPMAIIKSLKPMMESSSVKSILNISSEAGSISELPLKTYGYCISKAALNMF
                     TRMLERELKPENFKVVAVHPGWMKTEMGGEDAPYEPGEIARHLYERLTESPGKKADFNI
                     VDHLGNRMPP"
     gene            11381..11851
                     /gene="btrG"
     CDS             11381..11851
                     /codon_start=1
                     /db_xref="GOA:Q4H4F0"
                     /db_xref="InterPro:IPR005347"
                     /db_xref="UniProtKB/TrEMBL:Q4H4F0"
                     /gene="btrG"
                     /product="hypothetical protein"
                     /protein_id="CAG77425.1"
                     /transl_table=11
                     /translation="MISWTKAFTKPLKGRIFMPNLFVYGTLREGENNHKYMKEATLLSR
                     KASIAGSLVDTGNGYPGLLLENQLVAGEWYEVSEETLKRIDELEEYFGPGDTRNLFDRI
                     ECQVNESGGTHLGWTYVYNRDDYLETRFSDWKQYRLQHASGIEEKQDVPHSL"
     gene            11832..12740
                     /gene="btrH"
     CDS             11832..12740
                     /codon_start=1
                     /db_xref="InterPro:IPR000169"
                     /db_xref="UniProtKB/TrEMBL:Q4H4E9"
                     /function="unknown"
                     /gene="btrH"
                     /product="hypothetical protein"
                     /protein_id="CAG77426.1"
                     /transl_table=11
                     /translation="MCLTRYDEKFFDCRKSQIIAYLDSQQVPVIPLFYNSYQSTAEIYR
                     QIFIENKSKWKYSEPSFSDDDLLRKGIRPVRASFPDFSQASDCLKDLLARHKLVFVWGD
                     EYCLPYRKEAFQAIHSTHSLVVTGYDGENKAYYVEDWDGLYGYLPAVHLEAAFDSLSRQ
                     MRTLLVLELNDEEMRENKQEDTDLFRKWLQAFEDDYIFYDRVLLDMRDYEENRLISMDH
                     GLRLIAASRHVFSKFLHYIDDAPEEVGLLIRNHQLANHIAAIVRRYIIAKQIDWDGAAC
                     KIRQLREQEDDFMRKLKSRYG"
     gene            12809..13072
                     /gene="btrI"
     CDS             12809..13072
                     /NRPS_PKS="Domain: PP-binding (12-79). E-value: 1.8e-16.
                     Score: 52.3. Matches aSDomain:
                     nrpspksdomains_btrI_PP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:Q4H4E8"
                     /db_xref="InterPro:IPR003230"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q4H4E8"
                     /gene="btrI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl carrier protein"
                     /protein_id="CAG77427.1"
                     /sec_met_domain="PP-binding (E-value: 5.1e-17, bitscore:
                     52.3, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLETQENVRTAQIVSCVNEILQTKEFITPETDLFLLGLDSVTAV
                     NLIVSLESHFGITFNDDELIVENFSTVRKITEHVTVKLEEAL"
     aSDomain        12845..13045
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_btrI_PP-binding.1"
                     /evalue="1.80E-16"
                     /label="btrI_PP-binding.1"
                     /locus_tag="btrI"
                     /protein_end="79"
                     /protein_start="12"
                     /score="52.3"
                     /tool="antismash"
                     /translation="QIVSCVNEILQTKEFITPETDLFLLGLDSVTAVNLIVSLESHFGI
                     TFNDDELIVENFSTVRKITEHV"
     gene            13069..14328
                     /gene="btrJ"
     CDS             13069..14328
                     /codon_start=1
                     /db_xref="GOA:Q4H4E7"
                     /db_xref="InterPro:IPR003806"
                     /db_xref="InterPro:IPR005479"
                     /db_xref="InterPro:IPR011761"
                     /db_xref="UniProtKB/TrEMBL:Q4H4E7"
                     /gene="btrJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /product="putative biotin dependent carboxylase"
                     /protein_id="CAG77428.2"
                     /sec_met_domain="ATP-grasp (E-value: 1.2e-09, bitscore:
                     28.0, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp_3 (E-value: 2.9e-13, bitscore:
                     40.3, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFTHPLDYYRLNGKQILWYMNIGEDQDSQASNYFPSVKDPQSEK
                     IVVQQEQQLLFLARPQDTVFFHTMPEQAFLDYWKERRLSLPSIICCDKLSQVPDLERYT
                     IIPFIVSDQLLELKRRYPHMDIIAPDLAVCREINHKFNTRRLMERNGFNVTTGYFCSDI
                     ESLEHAYEQLISAGFSKCVLKVPYGSSGKGLKVIDNERNFRFLLNYIQNRQTNVDLLLE
                     GWHPHRLSLTSQLFITEYEVHLLAVTEQIIDPNGVYKGTNFTPALSQSEAADYREEILR
                     AGELIRQMGYRGVLGIDSILDTNGELIPVIEINARLTQVTYILPLVIEQKKRYEFVESR
                     VLVFNSRADLDFEDYENDLSEVTRDLPVRIDLYNFCKASGAFKNTYKLFVLVSAHNSEQ
                     LIKARSLLDELNTKMTTAVH"
     gene            14332..15642
                     /gene="btrK"
     CDS             14332..15642
                     /codon_start=1
                     /db_xref="GOA:Q2L4H3"
                     /db_xref="InterPro:IPR000183"
                     /db_xref="InterPro:IPR002986"
                     /db_xref="InterPro:IPR009006"
                     /db_xref="UniProtKB/TrEMBL:Q2L4H3"
                     /gene="btrK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_DAP_Arg_deC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Orn_Arg_deC_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1264:diaminopimelate decarboxylase (Score: 414.5;
                     E-value: 5.4e-126)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative glutamate decarboxylase"
                     /protein_id="CAG77429.1"
                     /sec_met_domain="Orn_DAP_Arg_deC (E-value: 5.1e-22,
                     bitscore: 68.2, seeds: 500, tool: rule-based-clusters)"
                     /sec_met_domain="Orn_Arg_deC_N (E-value: 1.6e-45, bitscore:
                     145.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKGGDLRMNLDQAEITALTKRFETPFYLYDGDFIEAHYRQLRSR
                     TNPAIQFYLSLKANNNIHLAKLFRQWGLGVEVASAGELALARHAGFSAENIIFSGPGKK
                     RSELEIAVQSGIYCIIAESVEELFYIEELAEKENKTARVAIRINPDKSFGSTAIKMGGV
                     PRQFGMDESMLDAVMDAVRSLQFTKFIGIHVYTGTQNLNTDSIIESMKYTVDLGRNIYE
                     RYGIVCECINLGGGFGVPYFSHEKALDIGKITRTVSDYVQEARDTRFPQTTFIIESGRY
                     LLAQAAVYVTEVLYRKASKGEVFVIVDGGMHHHAASTFRGRSMRSNYPMEYIPVREDSG
                     RRELEKVTIAGPLCTPEDCLGKDVHVPALYPGDLVCVLNSGAYGLSFSPVHFLGHPTPI
                     EILKRNGSYELIRRKGTADDIVATQLQTESNLLFVDK"
     gene            15670..16695
                     /gene="btrO"
     CDS             15670..16695
                     /codon_start=1
                     /db_xref="InterPro:IPR011251"
                     /db_xref="UniProtKB/TrEMBL:Q4H4E5"
                     /gene="btrO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1083:oxidoreductase (Score: 54.1; E-value: 2.5e-16)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative monoxygenase"
                     /protein_id="CAG77430.1"
                     /transl_table=11
                     /translation="MIALDTIQYYGQIPGVNHYNGKKEFMENAVKIAQLSDAYGIVGSL
                     SFFNHSVLDPWAVSSVIMRHTERHVPLIALQPYMYPPYTAAKLIQSFTYLYDRRIDLNM
                     ITGAVTGELQQTGGYIDHSSRYKKLHEYVQVLRLLLESDSAVSFKGDYYELNNLEFKPL
                     LPDKRLFPRIFMSGSSEEGLETGLKAADFVVTHPGPLEHFKRHFSEKVQGSAVQSAIRI
                     EIIARESAEQAWKIAHARYPGNRQGKIQLRMKTNSESSWQRMLAELALASETYDEVFWM
                     GGYMNGGIYSPVLVGDYEQVAAYLNEYYKLGVKAVLLGSMYSEEDFIHFSRVKEGISNP
                     V"
     gene            16739..17380
                     /gene="btrP"
     CDS             16739..17380
                     /codon_start=1
                     /db_xref="InterPro:IPR013078"
                     /db_xref="UniProtKB/TrEMBL:Q4H4E4"
                     /gene="btrP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101:phosphoglycerate mutase (Score: 102.8; E-value:
                     3.1e-31)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative mutase"
                     /protein_id="CAG77431.1"
                     /transl_table=11
                     /translation="MRLILIRHAQARCNILEDDALMDAYDPHCELTEAGIGQAVKLRDE
                     YPVSLTPSVIYSSPLKRARETAGIFRGRYPSVPFVEDERLSELKAPESFIPPITQGQWD
                     LYLEQRIRSPHLEIVKGLESLDVQRERIERFYKDLFRKYAEEACNIVIFTHAFSIQLSI
                     LFFLGLGNEQLLQWQIKASNTAMHIIHYDPTSGSFLLESLNNRSHLQTTG"
     gene            17707..19197
                     /gene="btrQ"
     CDS             17707..19197
                     /codon_start=1
                     /db_xref="GOA:Q2L4H0"
                     /db_xref="InterPro:IPR000172"
                     /db_xref="InterPro:IPR007867"
                     /db_xref="UniProtKB/TrEMBL:Q2L4H0"
                     /gene="btrQ"
                     /product="putative hexosaminyl 6'-dehydrogenase"
                     /protein_id="CAG77432.1"
                     /transl_table=11
                     /translation="MIGSGASGSVVSKYLAEKGLEVAIVEQGGLIEPGTNIDSVMSHAE
                     KAYARESDGTWGNNGYPWSASAVGGGTIFYAGISFRYKDVDFDAREYVASDALDPQWPI
                     GYSDLDPYYNKIEQWLGVSGDLNADPFKNSAGTGSLRTAHSYSQQGALIDQAGKELGLH
                     PFPTPLAVNTTDHNGYPGCDNLTSCTDYACPIGAKADSFTRILKPVLKLEHVTLMKNTK
                     ALAFHQTDPSVIDSLECLDLDTKERFHIRAKQFVLAGNAIQSAALVLRSTNKWWPDGVG
                     NKSGLVGSGLSFKNSEYVSGWVDNHPYEQLNEPLKGLYSTVSITDYYQDPHCHSGLGGL
                     IYEANPWTYYGHEGSGMYVQLECIIADQPMVTNKVRLSNDKEATGVPKIVLDYQTHEWD
                     KRRLSFMIERAGEILTAMGAKRVQCNPSYYYLGSAHLHGTCRAGTDERTSVVDKFGRFH
                     TIDNLFAADGSFMPFAGGVNPTLTIQANALRIAENMSV"
ORIGIN
        1 gatcaattcg ttcacgattt tgttaaatcc gtggaattaa agagcatcaa actcagccat
       61 aaagccgtcg ttcttacgga taagagactg gacagctaca accggctgct tgaagattcg
      121 tcgaaaatga cggccatcag cgactgtatc ggatcgaatc atctcagtca ttccatcgat
      181 tgtccttttt gcagccggtt aaaaaccgag cttctcggca aaaaaacggt tttgttcctg
      241 ggcagaatcg cacacgagaa aggctggtcc acctttgtaa gcgttgcgaa agagcttgcg
      301 gacaaaatcg gcgatttgca attcatcgtg tgcggggacg gtccccagcg cgaggcaatg
      361 gaagaacaaa ttaaagcggc gaatttgcag aaccaattcc gtatcaccgg ttttatttca
      421 cataaatttg tctcctgcta tctgcatcat gcccagctgt tcctgctgcc ctcccaccat
      481 gaggaattcg gcggaagcct gattgaagcg gccattgcgg gagttccgat catctcgacc
      541 aataacggag gtcccgccga tattttcact cacggtgaaa ccgcgatttt aaaagacccg
      601 ggcgacgtgt cggggatcgc tgacgaggct tataaaatat tgacgaacga ctccgtcgcc
      661 gagtccctga ggctccattc cagacccgag gttgtcagta aatttttgcc tcactgcgtg
      721 tatccgaatt atttgaattt gtactcttcc aaagaggctg ccgtccatga aggataatcc
      781 gatctctttg tttcacgaat tggaaagcta cgtcagagga agcaaggaca ctcttcatcg
      841 ttacatgtac gcctgtatcc tggagcagcg attggcggat ttgcttttgc tgagccggtg
      901 cggcgtacat cctgatgacg aggatcgtct ggccgtccgg ctggcctcac aacgcagcct
      961 ttgcgtacag gctgcttccg accttgcgga aggtacggag gaggcgcggg ggagtacacc
     1021 ggcatggccc gactgcaagg ttaccaaatc gtccgctgcg cagaaaagac cggagctgct
     1081 ctctttagtc aaagtgatgc aggagcttcg cacaccggaa tgctccgggt atgatttgtg
     1141 cgacctggag gtttgccggg aggatgctct gcactggctg agagaccatg ccgatccgtc
     1201 ttcaccgccc gtgctcatcg gcgttcgaac cggaggcgct ttctacgctc cgttatggtc
     1261 ttcggctttg cagcagaggt gggggaataa agccctatat cacaccgtca gagctctgcg
     1321 gatgccctcg gatccgggcg cgtccttgta tttgcccgag gaactttcga tactgccggc
     1381 ggcaatagag ccggatacgg atatcgtgat tctggaagac cagccgcata cgggcgggac
     1441 agttctggaa ctggccggaa gacttagcgc gaagtatcgg ctgaacaagc ctgtctgggt
     1501 ttcttctccg ggccggttgt tccaaatcga gaacggccgg cttgcgaagt gcagcgatcg
     1561 tatcccactg aatacgggga caagaaagcg catctggcag atgctcggca attcggaaga
     1621 agtggcggag tttcttctgc cgaagctcgg tttaactgac gcgcatccgg cggatttgga
     1681 agcggtccct tataaatccg tgcctcaatg gaatgatccg atgtatcgcc gtgaagttcc
     1741 ctttcggatt aatccgaaga aaactccgtt ttacatccga cgaaaaagca cgaatgagcc
     1801 ggtcgtattc gcaaaattta tcgggaaaga tcttttcggc gattttcaat ttcatcagct
     1861 gaagaagttt gaaaagtatt tccctgatat tttagcgtac caggacggtt atgtgatgac
     1921 caaatatgaa ccgggattaa aggaaatgag agaaatgttc gtcaacatgc cttcagccgt
     1981 gacaagggag atctgccaaa gcgtttccgg ttactggaaa acgctgcttg attcgtgcca
     2041 aataagcgga ggtcatcccg ttcatccttt agccgatcat tggcaggccc gtcttggaga
     2101 aatggaggac ttcatcggga gaaagctgcc ttatgatctg gattggttcg aacgaagttt
     2161 gcataccgaa tggacttcgt ccgctcatgt ttacacgtcc ttgccttacg ccaaccaata
     2221 cggacactgg aaagcgaggc tttcagccgg acaacgatta aaaacgtacc gttttcacat
     2281 cgattccacc tggggcggca cttccagcat cgaggtggag ctggcttcgt ttcttttgga
     2341 aaacagggtg aggcccgatg acttccgtct gctggtaaac caggtaaaaa aagaagccgg
     2401 ctccttaacc attgaagcgg ttaccgatgc cctgccgatc gcttgcgtcc tgcaagccgc
     2461 gaatctatta aaacaggcga aggatgaaag ccgcttgtcg aaagagctga ttttgtcgga
     2521 agcgatgcaa tcattcgagt atcttcaggc catgaagccg aagctttcgg atgtaagata
     2581 aatgtcacgg tcgaacgaaa ccacgcacat gtttgaggag gctttgtatg aatagcttcg
     2641 gaataaaatg cgagagactg ttggagctgc ggaacaatga aacgtttaca gcgcatattc
     2701 cccctcttta tccgatcgat cctaaaccag ccgttgagtt cctggaacaa tacagcggta
     2761 ccgaggaaga attgccgggt aggctggccc ggtacctaga gcagcgcgaa ccatcccgat
     2821 tcgatcaaat taaaaaagtt tgcggggacc ttccatggat tatcagaagc tccggggaag
     2881 aagacttaaa cgaaacgacg aatgccggcg cttatctcag tttagtttgt gagcacaggg
     2941 ataactttta cgaggtgctt gcgcaggtca tgctcagcgg aagcacggag cacgccagga
     3001 accagaatag acgtttcgtg agccgggatt tgcacgatca tgagcctatt cccgtgtttg
     3061 tccagccgct ggtccaatcg gagcatccgg gtcatcccgt tccttatgac gcaacccctt
     3121 atgtcaggaa agaggattta caaacgatca tcggtctgct taaaaacctc cacagcacca
     3181 tgccggacta tgcgcttgat tgcgaatggg taggggactc ggacttcgga acgatttcca
     3241 tgacaagctt aacggaactt gccgacggaa aactcacggg gcagattgct ttcggattcg
     3301 atcttttctc tacgcagcat gtgaaagcga acaatagtgt ccggtatctg ctgccgggcg
     3361 acgagttgaa cttgtggcag gggcatattt ttcaggaagt gaacatgcaa agtttgtttc
     3421 tcgtgcaaac aagaccggct aagaactacc gcttgttcca gcacgtctac gagctgtcgg
     3481 catcttccaa aaaagaattg gaaaaggatg ccgctctttg tctggatgca aaggagttca
     3541 tctcgcaggg cggcaagccg ttcttcggca agtttattaa ggcggtgacc ttgaacgaag
     3601 cctggaacgc ctatcttcag tacaccggca aagacgttaa ggaggatatc gccgctatcc
     3661 tggtggaatt cggtacgaga acggaacatg ccggaattat gtttaatcag gtcggaattc
     3721 cggtcattcg tatcgagatt gcgcttatac cggaaagtat gacttatatc gtacttgatc
     3781 cgttttccct gcagtgccgt ttgtacagcc acaacaaaga agtcaaggca ttggaatacg
     3841 agaccaggga aattattccc cttccggaca actgcattct tgttcaggat cgtgagggga
     3901 agcaccagca gcgggaggcc atggcggtat cggcggacga gtactttaac gaggtgttaa
     3961 acaagccctt cttctcggaa aagactaaag agcatttgac agcaaatagc gcctatccgg
     4021 cttacagctt catttttcat ggaaaagatg atgcccgctc accgagttac tacgcaaatg
     4081 acgccgaacg gttgacggct gaaacggttg acgatttttt aaaaagccgt gagtggccgg
     4141 aagcatcggc gaattatttc ctggccttat ttcatgcgaa aaacttgctc aaagacggga
     4201 acatcgccgc ttatgtcgga cggcagccgg atgaccgggg ccggtctaat gaaacgctcg
     4261 tgtactggaa ggtgctgcgc atccatcatc tgctggccaa atgcagcagc cgggaccggg
     4321 atacgctgtt ggagcgggtc cgtgcggaaa tgagcgttaa ttcggccgtc atcgagctgc
     4381 ggctggacgt gctgttttta ttcgagcaat atctggacgc cttgtgcatt tattcgaagc
     4441 gggaggaaga ggcgctgatc caaagcttta tcggcatact ttcttccgtt aaggatgaag
     4501 acctgccggt cgttctggat ctagcccgca acgggatttt taacgcgggt cacctgtgcc
     4561 aatttttaaa gcatgccata gagaaccggc acttgttcga tctttaccgg aactattctc
     4621 tagtcggcaa agagtttgcc atcattccgt acgatttgag cgtcgtcagc agattcccgt
     4681 attttaacga ggttttcgtt gatttgaaca acgagatgaa taaatacgag tcgctcggcg
     4741 agttaagcag ctctattttt cataccgtag tcgaaaccta cgataaatcg gccaaagaaa
     4801 ttcttttgag cgtgatagat gacggcagtc cgtcttatta tcaagcgtat ctcagactgt
     4861 taaccgaatg gctcggttta atccggcagt tcgataagaa cgagaaagtc attcaaactt
     4921 tccttgactg gatcggggtc caagaagatc ggcaagcgga aatcgaagat tacttcctgg
     4981 aagaaattca ttggaaaaca agaatagaag aagccgaggc gggtactgcc gaagacttgt
     5041 cgttaactaa tttgcatcag ctgcacaacg tgctgcacca gtggtcgttg cacttggttc
     5101 ccgcgtccaa tggcgctcat atgcctcttt tcgtcaaaga gatggtggcg ttcgcccaat
     5161 ctttttccga acaggaaaac cgattgctgc ggatgcaaaa agactttttt gaaatcgagc
     5221 tggcgatgtg tacgcacaag gcagggttta tgttctacaa gcattccgta actgtcgaat
     5281 ttagcgagcc tccttccgta catgacgacg aaatcgcgag actatcggct tttgcctctt
     5341 ttatgaacaa gtgcaacgat tggttcgagg cttatcgttt ccgcactcat tacgagaagg
     5401 tagccggaac ctggacctgt tatatgaccg taaaatccgt cgaagacggc gcacttcagc
     5461 aaagcgatta caaaacgatt tttcatatca taaggtttgt tttagacagc tcgtacgatt
     5521 tttcgcataa tccgctttct gcggttgagg atttgtccgc tcaattgaat gaaccggaat
     5581 ggaaagatat tttccggaag ctggtaaact atcgtgtcca ttttgacgat gaagggcagt
     5641 ttattaactt gaaattgttc gccatgtcca ctttctttac gtacctgtgt ctttcgccgt
     5701 ccctgcgaag ccgcctgctc tccttgtacc gggatggatt cgatcgtatg gtcggtgagc
     5761 tcgccgtact ggaagacggg atggcgcgcg ccggtcatta ctcggaatgg ctcgagcatt
     5821 atgaatcggc aacctatacc gccttattcc ttgcggctat ttatcctttg gagacagtgg
     5881 gcaagctgga gtcgctgcgt gaccggcggt tgacctacga tatcgtggcc agaaacttgc
     5941 tcaagcacaa agatgccgcc aataaagtta tcgagacgct gccaacctgg gataaagcgc
     6001 tgcaatccag tatgacggac aagctgctgc actattgtcc ggctaaattt ttcaaaaccg
     6061 tttcttctgt taacgaagtg gccaaggagc tctccaaacg aagcaaatcg tttaaacgtg
     6121 ccaagcaggt tttactcaac gcgtatgcgg attccttgga gccagacctt ttgcgacaat
     6181 tcatcgacga cttgcagtat gtcccttatg ccgggaccga ggcgcaaaat caacaactgg
     6241 ataaatacct gacggattcc gggaaaaaga gatatgacat tcaaaaagaa attttgtata
     6301 tctgatcgcc gtatcgcacg ttacgactaa ggagtgaacg atgaaatgaa acaggaaacg
     6361 gttaaaagtt cggaacagct gctatccgta ctcggtactt atatcgattc gccggtcgat
     6421 cccttccgca aggaaagagt gatgttttca aggggaagcg gggcttattt gttcgattac
     6481 gacggcggca attatatcga cctgatgaac gggaaagggt ctattatact ggggcacaac
     6541 gatccgagcg tcaatgccgc cttgcggaat tttctggagc aggaccgaga ggttgtaacg
     6601 ggtccttcca aaccgatcat tgatctggcc gaacggatca agaaagacag cgctttgccg
     6661 gatgcgaagg tttcgttcta tacgaccgga accgccgcct gcagagcggc cgtgtatgcc
     6721 gcacgcgatt acagcggcaa gaaaatcgtc ctcagctcgg gataccacgg ctgggatccc
     6781 atgtggaggc agcaggggcc actgctggaa ccgaatgagg atggggtgat cgagttttat
     6841 ttcatccccg agctgctgga acgcgcctta acggcgcata aggatcaagt cgccttggtc
     6901 atattttcgc cggactatac gtatttatcg gcttcgacga tggagagaat ccttggcata
     6961 tgccgggcgc acggagtcct ggtttgctgc gacgatgtga agcagggcta ccggcaccgt
     7021 caagggtctt cccttgagct tgtgacgact gagaaggccg acatgtacgt cttctccaaa
     7081 gggttgtcga acgggcaccg gatttcatgc gtggtgagtt cggacgagat catggcggag
     7141 accaaggagc acacgtacac ggcctactac cagatgctgc cgattctgtc gtccctggaa
     7201 acgctgaaaa aaatggaatc cggtaaaggc tacgatttga tacgttctta cggtcaaacc
     7261 ttgacgggga atttgaaaga gctgttcgtt caatcctctc tgcccatcga agtgaacggc
     7321 agctccattt ttcagctggt attcggagac gaagagctgg aggaggcgtt ttaccgggaa
     7381 gcctttattc agggactcat tctattcgag ggggataatc agtcgctttc cctgtgcatg
     7441 gacaaagacg ttcaagtgga cctgattcgc aggtttgcga acgtaaccga tgtcttatcg
     7501 gagcaattta aacacctgag aggaaaagag gttacgaccg agcaaacgtt cagaaccgct
     7561 tggaacatga ttgacggggc atcggatttg cttccctatg agaaacagct caaacttctc
     7621 gataatttga tcggtggagg ttaaacatga cgactaaaca aatttgtttt gcggaccggt
     7681 gttttaactt tgcattcggc gaacatgttt tggaatcggt tgaatcctat attccccggg
     7741 atgaattcga tcaatatatc atgatttcgg actcgggggt accggactcg attgttcatt
     7801 atgcggccga atacttcggc aaactcgccc ctgtacatat tcttcgcttt cagggcggag
     7861 aagaatacaa aacactttca accgtgacaa atttgcaaga gcgggcaatt gctctgggag
     7921 ccaaccgaag aaccgctatc gtagcggttg gcggagggtt aaccggaaac gttgccggag
     7981 tggcggccgg catgatgttt cgcgggattg cgcttattca cgttccgacc acgtttttgg
     8041 cggcctccga ttcggttctt tcgattaagc aggctgttaa tttaacgagc ggaaagaacc
     8101 tggtcggctt ttattatccg ccacgcttcg tgttcgccga tacccgaatc ttgtcggagt
     8161 cgccgccccg tcaggtgaaa gcgggaatgt gcgagctggt aaaaaatatg ctgattctgg
     8221 aaaacgacaa caaggaattt acagaggatg atttaaattc agccaatgtg tattctccga
     8281 agcagctgga gacgtttatc aacttctgca tatcggccaa aatgtcggta ttaagcgaag
     8341 atatttacga gaaaaagaag ggcctgatct ttgagtacgg ccatacgatc ggtcatgcga
     8401 tcgagcttgc cgagcaggga gggatcacgc acggagaagc cattgcagtg ggcatgattt
     8461 acgccgctaa aatagcgaac cggatgaacc tgatgcccga acatgacgtg tccgcccatt
     8521 actggctttt aaataaaatc ggggccttgc aggatattcc gctcaaatcg gacccggatt
     8581 cgatcttcca ttatttaatc cacgataaca agaggggcta cattaagctg gatgaggata
     8641 atttgggtat gattttactt agcggagtcg gtaaaccggc gatgtataac caaacgctgc
     8701 ttacaccggt cagaaaaacg ctcataaaag aagtgatccg ggaagggctg taaggatgaa
     8761 ccaggataag cgtgctttta tgttcatctc gcctcacttc gatgatgtca ttttgtcgtg
     8821 cgcctcgact ttaatggaac tgatgaatca ggggcacacc tgcaaggtgc tgaccgtatt
     8881 cgggggctgc ccgtcggttc gctttcagcc cggcgagatt gccagacagt acgcagccga
     8941 ggatttggga ttgttcgagg atgaaataga gggcgatcac ttgtccatac tcgtggcgcg
     9001 ccgactccag gaggatcagc aggcattccg gcatcttccc ggtgtacagg tcgaagtact
     9061 ttcctttccg gatgccatct acagggaaaa taaggggcag ccttattacc ggacggaggc
     9121 agacttattc ggcattccgg acaaacagga cgaagatatt ttcctgccta aaatcgaaac
     9181 ctatttgcag tcctgcgatc ttgcccggaa atacacctgg gtatttcccg ccatctccaa
     9241 acatgtcgat caccggctgc tgaccaaagc cggtttgagg ctgatgtcgc aagggtatcc
     9301 agtgcttttc tattccgaat ttccgtactg gcagcagcac aatgagtttt tacaggacgg
     9361 atggcgtcag ttggaattga gaaacagcgt ctacacaccg gtaaaaagag ccgctgtatt
     9421 ggaatacaaa acgcagctgc tcggattgtt cggcgaggag gcggaaacga aaatcaataa
     9481 cggcggagtc cttagcgaag ccgagctatt ttggatacaa gaaacggata ctcaagcttg
     9541 gcgggtattc cggtctttaa gtcccgaacc gcttcaaacc tgacacaaag aaaaggagtg
     9601 ctttccatgg aaattttaac gtacacgggt ccaagccgat taatcgtgga aacggcggaa
     9661 gaattgccgt taaagagcgg cgaatgccgg atacagtccc tctattccgg gatcagtcac
     9721 ggaacggaaa tgggggctta cagaggtatc gctccctatt tcacaagaga tatggattcc
     9781 gaaacccggt tgttcgagga tctggccgaa gaacataaag ttaaatatcc gatccggagc
     9841 tgcgaggacg atgcctggtt tatcgggtat tcgaacgtag ggaaaattat tgaagttgga
     9901 gcggaggtcg aaggatttac ggtcggagat atcgtgtttt cccacggcag gcatcaaacg
     9961 atcgtgtgca agcatcacaa aaagatcttt aaacttcccc aaaagctgga gcctgagctc
    10021 ggcattttct acacaaacct gatgacggct tataacgctg tattggacac gagaattaaa
    10081 atcggggacg ttgtcgtcgt gtcgggactc ggcgtagtcg ggcagttaat cgctcaatta
    10141 gccaaactgt ccggcgccac agtcgtcgga gtcgacccgc ttgagaacag actgaacatc
    10201 gccagggaag ttgaaatcga ctatgtgttt aatccgaatc ggacggatgt cgccaaggaa
    10261 atcagagaga ttacgaataa ccggggtgcc gatgccgtct tcgaagtatc cggtcattca
    10321 acggctttga atcaagcgat tcgcatagcg gcgccggaca cggtaattac agccgtaggc
    10381 tggtatcagg gcgggcaatc ggtgctgaat ctttccgaag aatttcacca gaaccggatt
    10441 acgatccgcg cttcgcaaac tctcgggatc gatccttcca tcagccatat gtatgacgat
    10501 gcgagaagaa ggaatatcgg gaaagatctg ctgcttaagc ttaaactccg caacctgatc
    10561 agccaccgga ttccgttcgg cgatgcgccg aaagcctacg aaatgatcga taaacacccg
    10621 catgaagttc tgcaggtcgt tctgacctac tcttaagggg gaagcccatg atcgttttca
    10681 taaccggcgc gaaccgcggg ctgggactga gtctttgcga ggtttttctg gaacggggac
    10741 atcaagttct tgccggagtg aggaacatga acagagccgg gcagctgctc ccgttaaaaa
    10801 ccaaatacaa ggaagagctg agcatcattc ccgtggatgt aagcagccag gattcaatcc
    10861 ggcaggctta ttccctgatt accgccgtga cgccaaagct tgacgcgatt atcaataatg
    10921 cggcccgtga aggcatccga tgcaaaaaga tccaggaagt ggacatcgcg gatttcgaag
    10981 aaacgtggaa aacgaacgtt ttgggtccga tggccattat caaatctctt aagcctatga
    11041 tggaaagcag ctcggtcaaa agcattctta atatcagctc cgaggccgga agtatttccg
    11101 agcttccttt gaaaacgtac ggctactgta tctccaaagc ggctctgaat atgtttaccc
    11161 gtatgctgga gagggaactg aaaccggaga actttaaggt ggttgcggtt caccccggct
    11221 ggatgaaaac cgaaatgggg ggagaggacg ccccttacga acccggtgaa atcgcccggc
    11281 atttgtacga acgcctcacg gaatcgcccg ggaaaaaggc tgatttcaac atcgtcgatc
    11341 atctaggaaa ccgcatgccc ccgtaagtga gtttaaggcg atgattagct ggacgaaagc
    11401 ttttaccaag ccgttaaagg ggagaatttt catgcccaac ttatttgtct acgggactct
    11461 gcgtgaggga gaaaacaacc acaagtatat gaaagaagcc accctgcttt cgcgaaaggc
    11521 cagcatagcc ggttccttgg tagataccgg caacggttac cccggcttac tgctggaaaa
    11581 tcagctggtg gcgggcgagt ggtatgaagt ctcggaagaa acgctgaaac ggatagatga
    11641 gctggaagag tatttcggtc ccggggatac aagaaactta tttgacagaa tcgaatgcca
    11701 agtaaacgag agcggcggaa cacatctggg ttggacgtac gtgtacaacc gggacgatta
    11761 cctggaaaca aggttttccg actggaaaca ataccggctg cagcatgctt ccggaataga
    11821 ggagaagcaa gatgtgcctc actcgttatg acgagaaatt tttcgattgc agaaaatcgc
    11881 agataatcgc ttatttggac tcacaacagg tccccgtcat tcctctattt tataacagtt
    11941 atcaaagcac agcggaaatt taccgccaga tctttatcga aaataagagc aaatggaagt
    12001 attcagagcc ttctttttcc gacgatgatt tactaagaaa aggaattagg cctgttcggg
    12061 cttcttttcc cgacttcagc caggcttcgg attgtttaaa ggatctgctg gcccggcata
    12121 aactcgtttt cgtatggggg gacgagtatt gtctgcctta ccggaaggaa gccttccagg
    12181 ccattcattc cactcattcg cttgttgtca cgggctatga cggtgagaac aaggcatact
    12241 acgtggaaga ttgggacggg ctctacggat atttgccggc tgtacatttg gaagcggctt
    12301 tcgacagtct gtccaggcag atgaggacat tgttggttct ggaactgaac gacgaggaaa
    12361 tgcgggaaaa caaacaagag gatacagatt tgttccggaa gtggctgcaa gccttcgagg
    12421 acgactatat cttctacgac cgggtgctgc tggatatgcg cgattatgag gaaaaccggc
    12481 tgatctcgat ggatcacgga cttcgtttaa tcgccgcatc ccggcatgtt ttctccaagt
    12541 ttcttcatta tatagatgac gccccggagg aggtcggcct ccttatccgc aaccatcaac
    12601 tcgctaacca tatcgcggcc atcgtcaggc ggtacattat cgccaaacag attgattggg
    12661 acggggcagc ttgcaagatt cggcaattaa gagagcaaga ggatgacttt atgcggaagc
    12721 taaagagccg ttacggctaa ttacggcagc aaaagcggat aaaccgctgt gcggaaaccg
    12781 ccatcccata cagaaggagt tgaatgtgat gtctttagaa actcaggaaa atgttcggac
    12841 cgctcaaatt gtatcttgcg tgaatgaaat tctgcagacg aaggaattca ttaccccgga
    12901 aaccgatttg tttctgcttg gcttggactc ggtaaccgcc gttaatctga tcgtcagttt
    12961 ggaaagccat ttcgggatca cgtttaacga cgacgaactg atcgtggaaa atttttcgac
    13021 ggtgcggaaa attacggaac atgtgacggt caaacttgag gaagccctat gaagttcact
    13081 catccgctgg attattatcg tctgaacggc aaacaaatcc tgtggtacat gaatatcggc
    13141 gaagatcagg acagccaggc gtcgaattac tttccctccg tcaaggaccc tcaatccgag
    13201 aagattgtcg tgcagcagga gcaacagctt ctctttctgg cgaggccgca ggacacggta
    13261 ttttttcata cgatgccgga gcaagccttt ctcgattatt ggaaagagcg ccgcctctcc
    13321 ttgccgtcga taatttgttg cgacaaactt tcgcaagtgc ctgatcttga gcgttatacg
    13381 attatcccgt ttattgtttc ggatcaactg cttgagctga agcggcggta tccgcatatg
    13441 gatatcattg cgccggattt ggcggtctgc cgggaaatca atcataagtt caatacgaga
    13501 agacttatgg agaggaacgg gtttaacgtc acaacgggtt atttctgcag cgatatcgag
    13561 agcttggagc atgcctacga acagctcatt tccgccggct tttccaaatg cgtgttgaaa
    13621 gttccatacg gctcgtcggg taaaggtctc aaagtcatcg acaacgaacg gaatttccgt
    13681 tttttgctga attatattca aaaccgccag acaaacgtcg acctgctcct ggaaggctgg
    13741 catccccacc gtctcagcct gacgtctcag cttttcatta ccgaatatga agtccatctt
    13801 ctggccgtca ccgagcaaat catagacccg aacggtgtct ataaaggaac gaattttacg
    13861 cctgccttat cgcaatcgga agcggccgat tatcgtgaag aaatcttacg ggcaggagaa
    13921 ctgatacggc agatggggta taggggcgtg cttgggatcg attcgatcct cgatacgaac
    13981 ggagaactga ttccggttat cgagattaac gccaggctca ctcaggtcac ctatattctt
    14041 ccgttggtta tcgaacagaa aaagcgttat gagtttgtcg aaagcagggt gctggtgttt
    14101 aattccagag cggatctgga ttttgaagat tacgaaaacg atctctcgga agtgacccgc
    14161 gatttaccgg tccgaatcga tctttacaat ttctgcaagg cttcgggagc ctttaaaaac
    14221 acctataagc tctttgtgtt agtttctgcc cacaattccg aacagctgat aaaagcccga
    14281 agcctgcttg acgagctgaa cacgaaaatg acaacggctg ttcattaact catgaagaag
    14341 ggaggggatt tgcggatgaa cctggatcaa gctgaaatca cggccttaac gaaaaggttt
    14401 gagactcctt tttatttgta tgacggcgat tttatcgaag cgcattaccg gcaattaaga
    14461 agccggacga acccggcgat ccagttttat ttgtccctaa aagcaaataa caatattcat
    14521 ctggccaaat tgttccggca gtggggactt ggcgtcgagg ttgcatccgc cggagaactc
    14581 gctttagccc ggcatgccgg attttcagcc gaaaacatca ttttctcggg accggggaag
    14641 aagcggagcg agctcgagat tgccgttcaa agcgggattt actgcatcat cgcggaatcc
    14701 gttgaagaac tcttttacat agaagaactg gctgaaaaag aaaacaaaac ggcccgcgtc
    14761 gcgatccgga tcaatcccga taaaagcttc ggcagcacgg ccatcaaaat gggcggagta
    14821 ccgagacagt tcggaatgga cgaatccatg ctggatgccg taatggatgc cgtccgctct
    14881 cttcaattca ccaaatttat cgggatacac gtatataccg gaacccagaa tctgaatacc
    14941 gacagcatta tcgagtcgat gaaatacacc gtagatctag gcagaaacat ttatgaacga
    15001 tacggaatcg tctgtgaatg tattaatctt ggcggagggt tcggagtccc gtatttttca
    15061 cacgaaaagg cactggatat cggcaaaatc acgcgtacgg tcagcgatta cgttcaagag
    15121 gcgagggata cacggttccc gcaaacgacc tttattatcg aaagcggaag atacttattg
    15181 gctcaagcgg ccgtgtatgt aaccgaggtg ctttaccgga aagcgtccaa aggagaagtt
    15241 tttgtgatcg tagacggggg aatgcaccac catgcggcct ccactttccg gggaagaagt
    15301 atgcggagca actaccccat ggaatatatt cccgttaggg aagactccgg ccgtcgcgaa
    15361 ctcgaaaaag tcaccattgc cggtcctctc tgtacgcccg aagattgtct agggaaggat
    15421 gtccatgtgc cggccttgta tccgggcgac ctcgtatgtg tgttgaactc gggagcttac
    15481 ggactgagct ttagcccggt tcattttctg gggcacccga cgcccattga aattctcaaa
    15541 cggaacggtt catacgagct gatcagacgg aaaggaacgg cggatgatat agtcgccacc
    15601 cagctgcaga cagaatcaaa tctcctcttt gtggacaaat agaaagccca atatacgaaa
    15661 agcaggggga tgattgcatt ggatacgatt cagtattatg gccaaattcc aggcgtcaac
    15721 cattataacg gcaagaaaga atttatggaa aacgccgtta aaatcgcgca gctgtccgat
    15781 gcttacggca tagtcgggtc cctgtcgttt tttaaccatt ccgtattgga cccttgggcc
    15841 gtaagctcgg ttattatgcg gcatacggaa cgtcatgttc ctctaattgc gcttcagccc
    15901 tacatgtatc ctccctatac ggctgccaag ttaattcaga gcttcactta tttgtacgac
    15961 cggcggatcg acttgaatat gatcaccggg gccgttaccg gcgagctcca gcaaaccggg
    16021 ggctatatcg atcattcgtc ccgctacaag aaacttcacg aatatgttca ggtgctccgt
    16081 ctgctgcttg aatccgattc tgccgtttcg ttcaaagggg actattatga gctgaataat
    16141 ttggagttca agcctttgct gccggacaaa cggcttttcc cgcgcatatt tatgtccggt
    16201 tcttccgagg aagggcttga aacgggtttg aaagcggcgg atttcgtcgt tactcatccg
    16261 ggaccgctgg aacattttaa acgccatttt agcgaaaagg tgcagggatc ggctgttcaa
    16321 agtgccataa gaatcgagat tatcgccaga gaatcggcgg agcaagcatg gaagatcgct
    16381 catgcccgtt atcccggcaa ccggcagggg aagatccagc tccggatgaa aacaaattcg
    16441 gaatcaagct ggcagcggat gctggccgaa ctggctttag cgagtgaaac gtacgatgaa
    16501 gtcttctgga tgggcgggta catgaacggc ggaatttaca gtcccgtgtt agtcggggat
    16561 tacgagcaag tggccgctta tttgaatgag tattacaaac tcggcgtgaa agccgtgttg
    16621 ctgggttcca tgtacagcga ggaggatttt attcatttca gccgggtgaa ggaaggaatt
    16681 tcgaatccgg tctagggacc ggaccgcgag caaacaatcc gacggaagga gagatagcat
    16741 gcgattgatt ttaatccgtc atgcgcaggc ccgctgcaat attctggagg acgacgctct
    16801 tatggacgct tacgatcctc attgcgagct gacggaagcg gggatcggcc aggccgtgaa
    16861 gctccgggac gaatacccgg tttctctgac gccgtcggtc atttattcca gccctttgaa
    16921 aagggcgagg gaaacggcgg gcattttccg cgggcgctat ccgtccgtgc ctttcgtcga
    16981 agacgaacgt ttgagcgagc tgaaagctcc ggagtctttt atcccgccga ttacgcaggg
    17041 gcagtgggat ctgtatctgg agcagcgtat ccggtcgcct catttggaaa tcgtcaaggg
    17101 gctagagtcg cttgacgtac agcgggaacg gatcgagcgg ttctataagg atctgttccg
    17161 gaagtatgcc gaagaagcgt gcaacatcgt catttttacc cacgctttca gcatccagct
    17221 gtccatcctg ttttttctcg gattaggaaa cgagcagctc ctgcaatggc aaatcaaagc
    17281 aagcaatacg gcgatgcaca tcattcatta cgacccgacc agcggcagtt ttctactgga
    17341 gagtctgaac aaccgttcac atctccaaac aaccggataa gaaaggatga aatgagatgg
    17401 ataacaaaga gcggaacacg ctgtatcaag tggtctacgc gatttccggc gtcaccggcg
    17461 aggacgggga cgagctcgtg gaaacgttta aacagggacc gatggaagtg gataagcggg
    17521 atttctttga aatcgttcaa cgggtcgaat cactgttcga ctgcacgctc gatatgaatt
    17581 tggaaggtcc ttatctgata catgccgatg aaatcgtgac taagattact aagctaaacg
    17641 tttagtcctg gccgttgaaa taagcaagta ggaggaatca ccttgaccaa gcaattcgat
    17701 gtatgcgtga tcggcagcgg agcaagcggt tccgttgtca gcaaatattt ggccgagaaa
    17761 gggttggaag tcgccattgt ggagcaaggc ggtctcattg aaccgggaac gaatatagat
    17821 tcggtcatga gccatgcgga gaaagcctac gcgagagagt cggacggaac ctgggggaat
    17881 aacggctatc cgtggtctgc cagcgcggtt ggcggcggaa cgatatttta tgccggtatc
    17941 tcattccgat acaaagacgt cgacttcgat gcgagggaat atgtggcgtc cgatgctctg
    18001 gacccccagt ggcccatcgg gtattcggat ttggacccct actacaacaa gatcgaacag
    18061 tggcttgggg tgtccgggga tttgaatgcc gatcccttca aaaacagtgc cggtaccggt
    18121 tcgctccgga cggcccattc ctacagccag cagggagccc tgatcgacca ggcgggcaaa
    18181 gagctcggcc tgcatccgtt tccgactccg ctggcggtta acacaacgga tcataacggc
    18241 tatccgggct gcgacaactt aaccagctgc acggattacg cgtgcccgat cggcgccaaa
    18301 gcggacagtt ttacgcgtat tttgaagccc gtgttgaagc tggagcatgt gacgctgatg
    18361 aaaaacacga aggctctggc gttccatcag acggacccgt ccgtaattga ctctttggaa
    18421 tgcctggatt tggacacgaa agaacggttc cacatcagag cgaaacaatt cgttctggcc
    18481 ggtaacgcca tccaaagcgc cgcgctcgtg ctgcgttcga cgaacaaatg gtggccggac
    18541 ggagtaggga acaaatccgg tctggtcggc tcgggattaa gtttcaagaa cagcgaatac
    18601 gtatccggct gggtggacaa tcatccttac gagcagttga acgaaccgct gaaaggattg
    18661 tactccaccg tttcgattac ggattattac caggacccgc attgccattc cggcctgggc
    18721 gggctgatct atgaagccaa tccgtggacc tattacggcc atgaaggcag cggcatgtat
    18781 gttcaattgg aatgtatcat agcggaccag cctatggtga ccaataaagt ccggctgtcg
    18841 aacgataaag aagccacggg ggtacccaaa attgtccttg attatcagac acatgaatgg
    18901 gacaagcgcc ggctgagctt tatgatcgag agggccggag aaattttgac ggccatggga
    18961 gccaagcggg tacaatgcaa cccttcctac tactatttag gaagcgctca tttgcatgga
    19021 acttgccgag caggcacgga tgagcggact tccgttgtcg ataagttcgg ccgattccac
    19081 acgatcgaca atttgtttgc ggccgacggg tccttcatgc cttttgcggg cggtgttaat
    19141 ccaaccttga cgatccaggc gaacgctcta agaatagccg aaaatatgag cgtctgatta
    19201 cgggcgacaa ccgggcggca cgggaaatcc ggaagcgggg aagtgatc
//
