BGC0000695: fortimicin biosynthetic gene cluster from Micromonospora olivasterospora
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Location: 1 - 47,238 nt. (total: 47,238 nt).
This entry is originally from NCBI GenBank AJ628421.2, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
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General information about the BGC
MIBiG accession BGC0000695
Short description fortimicin biosynthetic gene cluster from Micromonospora olivasterospora
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ628421.2
Compounds
  • fortimicin
Species Micromonospora olivasterospora [taxonomy]
References
Chemical products information
fortimicin
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C17H39N5O14S2
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF31530.1
 1 - 1416 (-) hypothetical protein
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  • CAF31531.1
 1547 - 2467 (-) putative transposase
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  • CAF31532.1
  • forY
 2968 - 4290 (+) ForY
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  • CAF31533.1
  • forH
 4629 - 6635 (+) putative component in exporter complex
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  • CAF31534.1
  • forI
 6632 - 8143 (+) putative component in exporter complex
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  • CAF31535.1
  • forJ
 8169 - 10031 (+) putative component in exporter complex
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  • CAF31536.1
  • forQ
 10124 - 11803 (+) putative fortimicin dehydrogenase
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  • CAF31537.1
  • forW
 11817 - 12680 (-) cytochrome c-type
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  • CAF31538.1
  • forV
 12677 - 14227 (-) putative transmembrane efflux protein
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  • CAF31539.1
  • forM
 14239 - 15522 (-) putative (N-acetyl-)hexosaminyltransferase
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  • CAF31540.1
  • forS
 15533 - 16804 (-) putative ketocyclitol aminotransferase I and II
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  • CAF31541.1
  • forE
 16801 - 17862 (-) putative (cyclitol-)dehydrogenase
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  • CAF31542.1
  • forO
 17859 - 18593 (-) putative fortimicin O-methyltransferase
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  • CAF31543.1
  • forL2
 18619 - 19758 (-) conserved hypothetical protein; putative fortimicin production protein
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  • CAF31544.1
  • forD
 19752 - 20660 (-) putative N-acetylhexosaminyl deacetylase
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  • CAF31545.1
  • forP
 20660 - 21484 (-) putative fortimicin 3'-phosphotransferase (biosynthetic)
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  • CAF31546.1
  • forB
 21486 - 22814 (-) putative fortimicin 6'-aminotransferase
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  • CAF31547.1
  • forK
 23004 - 24665 (-) fortimicin KL1 C-methyltransferase
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  • CAF31548.1
  • forZ
 24691 - 26139 (-) fortimicin A N-forimidoyltransferase
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  • CAF31549.1
  • forX
 26925 - 27392 (+) putative fortimicin production protein
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  • CAF31550.1
  • forG
 27450 - 28511 (+) putative myo-inositol 3-dehydrogenase
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  • CAF31551.1
  • forN
 28508 - 29350 (+) putative fortimicin N-methyltransferase
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  • CAF31552.1
  • forA
 29359 - 30204 (+) putative myo-inositol-3-phosphate phosphatase
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  • CAF31553.1
  • forL
 30466 - 31254 (-) putative fortimicin biosynthetic oxidoreductase
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  • CAF31554.1
  • fmrR
 31607 - 31906 (+) hypothetical protein
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  • CAF31555.1
  • fmrO
 31944 - 32825 (+) 16S rRNA methyltransferase
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  • CAF31556.1
  • forT
 32936 - 33877 (+) putative fortimicin production protein
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  • CAF31557.1
  • fosG
 33910 - 34266 (-) putative fortimicin production protein
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  • CAF31558.1
  • fosF
 34266 - 34904 (-) putative fortimicin production protein
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  • CAF31559.1
  • fosE
 34911 - 35612 (-) putative fortimicin production protein; unknown ATP/GTP-binding protein
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  • CAF31560.1
  • fosD
 35772 - 36185 (-) possible fortimicin production protein
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  • CAF31561.1
  • fosC
 36526 - 36897 (-) possible fortimicin production protein
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  • CAF31562.1
  • fmrP
 36896 - 37372 (+) 16S rRNA methyltransferase; fortimicin resistance
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  • CAF31563.1
  • fmrB
 37713 - 38522 (-) 16S rRNA methyltransferase
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  • CAF31564.1
  • fosA
 38531 - 39688 (-) possible fortimicin production protein
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  • CAF31565.1
  • MolI14.36
 40025 - 41155 (+) conserved hypothetical protein
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  • CAF31566.1
  • MolI14.37
 41180 - 42595 (+) putative tryptophanase
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  • CAF31567.1
  • MolJ05.1c_rename1
 42675 - >42806 (-) putative ATP/GTP-binding protein
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  • CAG38669.1
  • MolJ05.1c
 42675 - 43229 (-) putative GTPase
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  • CAG38670.1
  • MolJ05.2c
 43274 - 43639 (-) conserved hypothetical protein
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  • CAG38671.1
  • MolJ05.3c
 43636 - 44064 (-) conserved hypothetical protein
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  • CAG38672.1
  • MolJ05.4c
 44075 - 45499 (-) putative signal transduction histidine kinase
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  • CAG38673.1
  • MolJ05.5c
 46148 - 47035 (-) putative acetyltransferase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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Modifications to original record
  • renamed CDS with name MolJ05.1c at [42674:>42806](-) to MolJ05.1c_rename1 to avoid duplicates