BGC0000696: gentamicin biosynthetic gene cluster from Micromonospora echinospora
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Location: 1 - 84,222 nt. (total: 84,222 nt).
This entry is originally from NCBI GenBank AJ628149.4.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000696
Short description gentamicin biosynthetic gene cluster from Micromonospora echinospora
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ628149.4
Compounds
  • gentamicin
Species Micromonospora echinospora [taxonomy]
References
Chemical products information
gentamicin
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C18H36N4O10
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG38674.1
 191 - 1264 (+) putative DNA polymerase beta chain
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  • CAG38675.1
 1347 - 2321 (-) putative integral membrane protein
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  • CAG38676.1
 2374 - 2847 (+) hypothetical protein
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  • CAG38677.1
 2847 - 4517 (+) hypothetical protein
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  • CAG38678.1
 4571 - 5590 (-) putative plus agglutinin
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  • CAG38679.1
 5628 - 6206 (-) hypothetical protein
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  • CAG38680.1
 6297 - 6899 (-) putative esterase
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  • CAG38681.1
 7683 - 9389 (+) hypothetical protein
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  • CAG38682.1
 9518 - 10144 (-) hypothetical protein
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  • CAF31421.1
 16081 - 16620 (+) hypothetical protein
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  • CAF31422.1
 16711 - 17790 (+) putative Trp-tRNA ligase
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  • CAF31423.1
  • genO
 17857 - 19014 (+) queuine /archaeosine tRNA-ribosyltransferase
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  • CAF31424.1
  • gmrB
 19121 - 19939 (+) putative ribosomal methyltransferase
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  • CAF31425.1
  • genB1
 19953 - 21206 (-) gentamicin (hexosaminyl-6-) aminotransferase I
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  • CAF31426.2
  • genQ
 21238 - 22761 (-) gentamicin hexosamiyl-6'-dehydrogenase
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  • CAF31427.1
  • genD3
 22934 - 23743 (-) putative gentamicin oxidoreductase
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  • CAF31428.1
  • genM1
 23758 - 25005 (-) putative (N-acetyl-)hexosaminyltransferase
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  • CAF31429.1
  • gmrA
 25042 - 25866 (-) putative ribosomal methyltransferase
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  • CAF31430.1
  • genS1
 26161 - 27423 (+) putative L-glutamine:ketocyclitol aminotransferase
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  • CAF31431.1
  • genC
 27558 - 28751 (+) 2-deoxy-scyllo-inosose synthase
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  • CAF31432.1
  • genD2
 28744 - 29769 (+) putative gentamicin oxidoreductase
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  • CAF31433.1
  • genM2
 29858 - 31030 (+) putatative gentamicin glycosyltransferase II
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  • CAF31434.1
  • genD1
 31032 - 33011 (+) putative gentamicin oxidoreductase
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  • CAF31435.1
  • genS2
 33011 - 34267 (+) putative gentamicin aminotransferase II
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  • CAF31436.2
  • genW
 34275 - 34646 (+) putative gentamicin production protein
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  • CAF31437.2
  • genB4
 34741 - 36078 (-) putative gentamicin aminotransferase IV
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  • CAF31438.1
  • genP
 36137 - 36943 (-) biosynthetic aminoglycoside 3'-phosphotransferase
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  • CAF31439.1
  • genB3
 36981 - 38453 (-) putative gentamicin aminotransferase III
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  • CAF31440.1
  • genK
 38969 - 40885 (-) putative gentamicin C-methyltransferase
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  • CAF31441.1
  • genB2
 41135 - 42379 (+) putative gentamicin aminotransferase II
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  • CAF31442.1
  • genX
 42465 - 42977 (-) putative gentamicin production protein
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  • CAF31443.1
  • genU
 43032 - 43967 (-) putative gentamicin production protein
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  • CAF31444.1
  • genV
 44162 - 45568 (-) putative gentamicin exporter
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  • CAF31445.1
  • genE
 45861 - 46883 (-) putative aminocyclitol 1-dehydrogenase
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  • CAF31446.1
  • genY
 47364 - 48878 (+) putative kation antiporter
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  • CAF31447.1
  • genA
 49000 - 49737 (+) putative gentamicin production protein
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  • CAF31448.1
  • genF
 49734 - 50381 (+) putative gentamicin production protein
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  • CAF31449.1
  • genG
 50381 - 50734 (+) putative gentamicin production protein
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  • CAF31450.1
  • genH
 50813 - 54229 (-) putative gentamicin exporter
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  • CAF31451.1
  • genI
 54226 - 56163 (-) putative gentamicin exporter
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  • CAF31452.1
  • genT
 56689 - 57627 (-) putative gentamicin production protein
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  • CAF31453.1
  • genD_
 58121 - 58741 (+) putative gentamicin production protein
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  • CAF31454.1
  • genN
 58738 - 59703 (+) putative gentamicin methyltransferase
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  • CAF31455.1
 59890 - 60393 (-) hypothetical protein
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  • CAF31456.2
 60531 - 61847 (-) putative two-component system histidine kinase
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  • CAF31457.2
 61844 - 62539 (-) putative two-component system response regulator
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  • CAH05237.1
 62642 - 63127 (+) putatative secreted serine protease
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  • CAH05238.1
 63146 - 64306 (-) DNA polymerase III, epsilon subunit
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  • CAH05239.1
 64376 - 65029 (-) hypothetical protein
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  • CAH05240.1
 65468 - 66505 (+) hypothetical protein
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  • CAI05917.1
 66654 - 67121 (-) hypothetical protein
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  • CAI05918.1
 67093 - 67749 (-) putative RNA polymerase sigma factor
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  • CAI05919.1
 67746 - 69038 (-) putative serine protease, subtilase family
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  • CAI05920.1
 69189 - 71837 (+) hypothetical protein
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  • CAI05921.1
 71927 - 72430 (-) hypothetical protein
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  • CAI05922.1
 72525 - 73883 (+) hypothetical protein
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  • CAI05923.1
 74039 - 74419 (+) putative glycosyltransferase
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  • CAI05924.1
 74652 - 74945 (-) hypothetical protein
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  • CAI05925.1
 75043 - 76086 (-) hypothetical protein
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  • CAI05926.1
 76282 - 77409 (+) putative transcriptional regulator
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  • CAI05927.1
 77449 - 77631 (-) putative acetyltransferase
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  • CAI05928.1
 77879 - 80164 (+) hypothetical protein
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  • CAI05929.1
 80301 - 82640 (+) hypothetical protein
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  • CAI05930.1
 82646 - 83617 (+) putative ATP-binding protein
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  • CAI05931.1
 83614 - >84222 (+) putative ABC-transporter, permease component
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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