BGC0000696: gentamicin biosynthetic gene cluster from Micromonospora echinospora
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Location: 1 - 84,222 nt. (total: 84,222 nt).
This entry is originally from NCBI GenBank AJ628149.4.

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core biosynthetic genes
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resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000696
Short description gentamicin biosynthetic gene cluster from Micromonospora echinospora
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ628149.4
via
Compounds
  • gentamicin
Species Micromonospora echinospora [taxonomy]
References
Chemical products information
gentamicin Evidence:
Copy SMILES
C18H36N4O10
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAG38674.1
 191 - 1264 (+) putative DNA polymerase beta chain
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    • CAG38675.1
    		 1347 - 2321 (-) putative integral membrane protein
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      • CAG38676.1
      		 2374 - 2847 (+) hypothetical protein
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        • CAG38677.1
        		 2847 - 4517 (+) hypothetical protein
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          • CAG38678.1
          		 4571 - 5590 (-) putative plus agglutinin
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            • CAG38679.1
            		 5628 - 6206 (-) hypothetical protein
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              • CAG38680.1
              		 6297 - 6899 (-) putative esterase
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                • CAG38681.1
                		 7683 - 9389 (+) hypothetical protein
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                  • CAG38682.1
                  		 9518 - 10144 (-) hypothetical protein
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                    • CAF31421.1
                    		 16081 - 16620 (+) hypothetical protein
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                      • CAF31422.1
                      		 16711 - 17790 (+) putative Trp-tRNA ligase
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                        • CAF31423.1
                        • genO
                        		 17857 - 19014 (+) queuine /archaeosine tRNA-ribosyltransferase
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                          • CAF31424.1
                          • gmrB
                          		 19121 - 19939 (+) putative ribosomal methyltransferase
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                            • CAF31425.1
                            • genB1
                            		 19953 - 21206 (-) gentamicin (hexosaminyl-6-) aminotransferase I
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                              • CAF31426.2
                              • genQ
                              		 21238 - 22761 (-) gentamicin hexosamiyl-6'-dehydrogenase
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                                • CAF31427.1
                                • genD3
                                		 22934 - 23743 (-) putative gentamicin oxidoreductase
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                                  • CAF31428.1
                                  • genM1
                                  		 23758 - 25005 (-) putative (N-acetyl-)hexosaminyltransferase
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                                    • CAF31429.1
                                    • gmrA
                                    		 25042 - 25866 (-) putative ribosomal methyltransferase
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                                      • CAF31430.1
                                      • genS1
                                      		 26161 - 27423 (+) putative L-glutamine:ketocyclitol aminotransferase
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                                        • CAF31431.1
                                        • genC
                                        		 27558 - 28751 (+) 2-deoxy-scyllo-inosose synthase
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                                          • CAF31432.1
                                          • genD2
                                          		 28744 - 29769 (+) putative gentamicin oxidoreductase
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                                            • CAF31433.1
                                            • genM2
                                            		 29858 - 31030 (+) putatative gentamicin glycosyltransferase II
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                                              • CAF31434.1
                                              • genD1
                                              		 31032 - 33011 (+) putative gentamicin oxidoreductase
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                                                • CAF31435.1
                                                • genS2
                                                		 33011 - 34267 (+) putative gentamicin aminotransferase II
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                                                  • CAF31436.2
                                                  • genW
                                                  		 34275 - 34646 (+) putative gentamicin production protein
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                                                    • CAF31437.2
                                                    • genB4
                                                    		 34741 - 36078 (-) putative gentamicin aminotransferase IV
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                                                      • CAF31438.1
                                                      • genP
                                                      		 36137 - 36943 (-) biosynthetic aminoglycoside 3'-phosphotransferase
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                                                        • CAF31439.1
                                                        • genB3
                                                        		 36981 - 38453 (-) putative gentamicin aminotransferase III
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                                                          • CAF31440.1
                                                          • genK
                                                          		 38969 - 40885 (-) putative gentamicin C-methyltransferase
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                                                            • CAF31441.1
                                                            • genB2
                                                            		 41135 - 42379 (+) putative gentamicin aminotransferase II
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                                                              • CAF31442.1
                                                              • genX
                                                              		 42465 - 42977 (-) putative gentamicin production protein
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                                                                • CAF31443.1
                                                                • genU
                                                                		 43032 - 43967 (-) putative gentamicin production protein
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                                                                  • CAF31444.1
                                                                  • genV
                                                                  		 44162 - 45568 (-) putative gentamicin exporter
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                                                                    • CAF31445.1
                                                                    • genE
                                                                    		 45861 - 46883 (-) putative aminocyclitol 1-dehydrogenase
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                                                                      • CAF31446.1
                                                                      • genY
                                                                      		 47364 - 48878 (+) putative kation antiporter
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                                                                        • CAF31447.1
                                                                        • genA
                                                                        		 49000 - 49737 (+) putative gentamicin production protein
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                                                                          • CAF31448.1
                                                                          • genF
                                                                          		 49734 - 50381 (+) putative gentamicin production protein
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                                                                            • CAF31449.1
                                                                            • genG
                                                                            		 50381 - 50734 (+) putative gentamicin production protein
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                                                                              • CAF31450.1
                                                                              • genH
                                                                              		 50813 - 54229 (-) putative gentamicin exporter
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                                                                                • CAF31451.1
                                                                                • genI
                                                                                		 54226 - 56163 (-) putative gentamicin exporter
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                                                                                  • CAF31452.1
                                                                                  • genT
                                                                                  		 56689 - 57627 (-) putative gentamicin production protein
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                                                                                    • CAF31453.1
                                                                                    • genD_
                                                                                    		 58121 - 58741 (+) putative gentamicin production protein
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                                                                                      • CAF31454.1
                                                                                      • genN
                                                                                      		 58738 - 59703 (+) putative gentamicin methyltransferase
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                                                                                        • CAF31455.1
                                                                                        		 59890 - 60393 (-) hypothetical protein
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                                                                                          • CAF31456.2
                                                                                          		 60531 - 61847 (-) putative two-component system histidine kinase
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                                                                                            • CAF31457.2
                                                                                            		 61844 - 62539 (-) putative two-component system response regulator
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                                                                                              • CAH05237.1
                                                                                              		 62642 - 63127 (+) putatative secreted serine protease
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                                                                                                • CAH05238.1
                                                                                                		 63146 - 64306 (-) DNA polymerase III, epsilon subunit
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                                                                                                  • CAH05239.1
                                                                                                  		 64376 - 65029 (-) hypothetical protein
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                                                                                                    • CAH05240.1
                                                                                                    		 65468 - 66505 (+) hypothetical protein
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                                                                                                      • CAI05917.1
                                                                                                      		 66654 - 67121 (-) hypothetical protein
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                                                                                                        • CAI05918.1
                                                                                                        		 67093 - 67749 (-) putative RNA polymerase sigma factor
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                                                                                                          • CAI05919.1
                                                                                                          		 67746 - 69038 (-) putative serine protease, subtilase family
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                                                                                                            • CAI05920.1
                                                                                                            		 69189 - 71837 (+) hypothetical protein
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                                                                                                              • CAI05921.1
                                                                                                              		 71927 - 72430 (-) hypothetical protein
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                                                                                                                • CAI05922.1
                                                                                                                		 72525 - 73883 (+) hypothetical protein
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                                                                                                                  • CAI05923.1
                                                                                                                  		 74039 - 74419 (+) putative glycosyltransferase
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                                                                                                                    • CAI05924.1
                                                                                                                    		 74652 - 74945 (-) hypothetical protein
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                                                                                                                      • CAI05925.1
                                                                                                                      		 75043 - 76086 (-) hypothetical protein
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                                                                                                                        • CAI05926.1
                                                                                                                        		 76282 - 77409 (+) putative transcriptional regulator
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                                                                                                                          • CAI05927.1
                                                                                                                          		 77449 - 77631 (-) putative acetyltransferase
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                                                                                                                            • CAI05928.1
                                                                                                                            		 77879 - 80164 (+) hypothetical protein
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                                                                                                                              • CAI05929.1
                                                                                                                              		 80301 - 82640 (+) hypothetical protein
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                                                                                                                                • CAI05930.1
                                                                                                                                		 82646 - 83617 (+) putative ATP-binding protein
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                                                                                                                                  • CAI05931.1
                                                                                                                                  		 83614 - >84222 (+) putative ABC-transporter, permease component
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                                                                                                                                    Biosynthesis information
                                                                                                                                    Annotation changelog

                                                                                                                                    Entry version: 4

                                                                                                                                    Date
                                                                                                                                    Changes
                                                                                                                                    Submitters
                                                                                                                                    Reviewers
                                                                                                                                    2022-10-07
                                                                                                                                    Update chemical activity to schema version 2.11
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                    Entry version: 3

                                                                                                                                    Date
                                                                                                                                    Changes
                                                                                                                                    Submitters
                                                                                                                                    Reviewers
                                                                                                                                    2022-09-15
                                                                                                                                    Updated bioactivity data
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                    Entry version: 2

                                                                                                                                    Date
                                                                                                                                    Changes
                                                                                                                                    Submitters
                                                                                                                                    Reviewers
                                                                                                                                    2019-10-16
                                                                                                                                    Migrated from v1.4
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    2019-10-16
                                                                                                                                    Updated reference publication(s) (MIBiG Annotathon)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    2019-10-16
                                                                                                                                    Updated compound(s) information (NPAtlas curation)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                    Entry version: 1

                                                                                                                                    Date
                                                                                                                                    Changes
                                                                                                                                    Submitters
                                                                                                                                    Reviewers
                                                                                                                                    2015-06-12
                                                                                                                                    Submitted
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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