BGC0000699: hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus
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Location: 1 - 34,921 nt. (total: 34,921 nt).
This entry is originally from NCBI GenBank AJ628642.1.

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core biosynthetic genes
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000699
Short description hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ628642.1
via
Compounds
  • hygromycin A
Species Streptomyces hygroscopicus subsp. hygroscopicus [taxonomy]
References
Chemical products information
hygromycin A Evidence:
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C23H29N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF31829.1
 26 - 520 (+) hypothetical protein
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    • CAF31830.1
    		 520 - 849 (+) hypothetical protein
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      • CAF31831.1
      		 855 - 1853 (+) putative iron transport lipoprotein
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        • CAF31832.1
        		 1888 - 2652 (+) hypothetical protein
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          • CAF31833.1
          		 2649 - 3695 (+) putative iron ABC transporter
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            • CAF31834.1
            		 3692 - 4510 (+) hypotheticl protein
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              • CAF31835.1
              		 4650 - 5684 (+) hypothetical protein
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                • CAF31836.1
                		 5728 - 7119 (+) putative transposase
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                  • CAF31837.1
                  • hygV
                  		 7116 - 8966 (-) putative hygromycin B exporter
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                    • CAF31838.1
                    • hygW
                    		 8963 - 10777 (-) putative hygromycin B exporter
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                      • CAF31839.1
                      • hygA
                      		 10938 - 11936 (+) hygromycin-B kinase
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                        • CAF31840.1
                        • hygK
                        		 12089 - 13048 (-) putative NDP-heptose/hexose dehydrogenase
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                          • CAF31841.1
                          • hygU
                          		 13051 - 13539 (-) putative phosphatase
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                            • CAF31842.1
                            • hygD
                            		 13666 - 14871 (+) putative glycosyltransferase II
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                              • CAF31843.1
                              • hygO
                              		 14916 - 15779 (-) putative NDP-heptose/hexose synthase
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                                • CAF31844.1
                                • hygE
                                		 15783 - 16802 (-) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
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                                  • CAF31845.1
                                  • hygP
                                  		 16900 - 17496 (-) putative phosphoheptose isomerase
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                                    • CAF31846.1
                                    • hygX
                                    		 17601 - 18377 (-) putative oxidase/hydroxylase
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                                      • CAF31847.1
                                      • hygL
                                      		 18557 - 19690 (-) putative NDP-heptose aminotransferase
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                                        • CAF31848.1
                                        • hygJ
                                        		 19687 - 20613 (-) putative NDP-(heptose/hexose) epimerase/ dehydrogenase
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                                          • CAF31849.1
                                          • hygY
                                          		 20613 - 21644 (-) putative oxidoreductase
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                                            • CAF31850.1
                                            • hygF
                                            		 21655 - 22467 (-) putative aminocyclitol galactosyltransferase
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                                              • CAF31851.1
                                              • hygN
                                              		 22650 - 23705 (-) putative heptose-(7-phosphate)-1-phosphotransferase
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                                                • CAF31852.1
                                                • hygC
                                                		 23702 - 24934 (-) putative 2-deoxy-scyllo-inosose synthase
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                                                  • CAF31853.1
                                                  • hygM
                                                  		 24940 - 25758 (-) putative 3-N-methyltransferase
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                                                    • CAF31854.1
                                                    • hygS
                                                    		 25930 - 27234 (-) putative bifunctional L-glutamine:2-deoxy ketocyclitol aminotransferase I and II
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                                                      • CAF31855.1
                                                      • hygT
                                                      		 27361 - 27909 (+) putative hygromycin B biosynthetic protein
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                                                        • CAF31856.1
                                                        • hygI
                                                        		 27910 - 28401 (+) putative hygromycin B biosynthetic protein
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                                                          • CAF31857.1
                                                          • hygH
                                                          		 28500 - 29006 (+) putative hygromycin B biosynthetic protein
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                                                            • CAF31858.1
                                                            • hygG
                                                            		 29008 - 30186 (+) putative hygromycin B biosynthetic protein
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                                                              • CAF31859.1
                                                              • hygZ
                                                              		 30540 - 32528 (-) putative transposase
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                                                                • CAF31860.1
                                                                		 32660 - 33520 (-) hypothetical protein
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                                                                  • CAF31861.1
                                                                  		 33571 - 34914 (-) putative DNA-binding protein
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                                                                    Biosynthesis information
                                                                    Annotation changelog

                                                                    Entry version: 4

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-10-07
                                                                    Update chemical activity to schema version 2.11
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 3

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2022-09-15
                                                                    Updated bioactivity data
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 2

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2019-10-16
                                                                    Migrated from v1.4
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated reference publication(s) (MIBiG Annotathon)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    2019-10-16
                                                                    Updated compound(s) information (NPAtlas curation)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                    Entry version: 1

                                                                    Date
                                                                    Changes
                                                                    Submitters
                                                                    Reviewers
                                                                    2015-06-12
                                                                    Submitted
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                    • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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