BGC0000699: hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus
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Location: 1 - 34,921 nt. (total: 34,921 nt).
This entry is originally from NCBI GenBank AJ628642.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000699
Short description hygromycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. hygroscopicus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ628642.1
Compounds
  • hygromycin A
Species Streptomyces hygroscopicus subsp. hygroscopicus [taxonomy]
References
Chemical products information
hygromycin A
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C23H29N1O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF31829.1
 26 - 520 (+) hypothetical protein
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  • CAF31830.1
 520 - 849 (+) hypothetical protein
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  • CAF31831.1
 855 - 1853 (+) putative iron transport lipoprotein
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  • CAF31832.1
 1888 - 2652 (+) hypothetical protein
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  • CAF31833.1
 2649 - 3695 (+) putative iron ABC transporter
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  • CAF31834.1
 3692 - 4510 (+) hypotheticl protein
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  • CAF31835.1
 4650 - 5684 (+) hypothetical protein
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  • CAF31836.1
 5728 - 7119 (+) putative transposase
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  • CAF31837.1
  • hygV
 7116 - 8966 (-) putative hygromycin B exporter
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  • CAF31838.1
  • hygW
 8963 - 10777 (-) putative hygromycin B exporter
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  • CAF31839.1
  • hygA
 10938 - 11936 (+) hygromycin-B kinase
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  • CAF31840.1
  • hygK
 12089 - 13048 (-) putative NDP-heptose/hexose dehydrogenase
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  • CAF31841.1
  • hygU
 13051 - 13539 (-) putative phosphatase
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  • CAF31842.1
  • hygD
 13666 - 14871 (+) putative glycosyltransferase II
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  • CAF31843.1
  • hygO
 14916 - 15779 (-) putative NDP-heptose/hexose synthase
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  • CAF31844.1
  • hygE
 15783 - 16802 (-) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
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  • CAF31845.1
  • hygP
 16900 - 17496 (-) putative phosphoheptose isomerase
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  • CAF31846.1
  • hygX
 17601 - 18377 (-) putative oxidase/hydroxylase
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  • CAF31847.1
  • hygL
 18557 - 19690 (-) putative NDP-heptose aminotransferase
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  • CAF31848.1
  • hygJ
 19687 - 20613 (-) putative NDP-(heptose/hexose) epimerase/ dehydrogenase
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  • CAF31849.1
  • hygY
 20613 - 21644 (-) putative oxidoreductase
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  • CAF31850.1
  • hygF
 21655 - 22467 (-) putative aminocyclitol galactosyltransferase
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  • CAF31851.1
  • hygN
 22650 - 23705 (-) putative heptose-(7-phosphate)-1-phosphotransferase
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  • CAF31852.1
  • hygC
 23702 - 24934 (-) putative 2-deoxy-scyllo-inosose synthase
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  • CAF31853.1
  • hygM
 24940 - 25758 (-) putative 3-N-methyltransferase
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  • CAF31854.1
  • hygS
 25930 - 27234 (-) putative bifunctional L-glutamine:2-deoxy ketocyclitol aminotransferase I and II
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  • CAF31855.1
  • hygT
 27361 - 27909 (+) putative hygromycin B biosynthetic protein
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  • CAF31856.1
  • hygI
 27910 - 28401 (+) putative hygromycin B biosynthetic protein
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  • CAF31857.1
  • hygH
 28500 - 29006 (+) putative hygromycin B biosynthetic protein
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  • CAF31858.1
  • hygG
 29008 - 30186 (+) putative hygromycin B biosynthetic protein
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  • CAF31859.1
  • hygZ
 30540 - 32528 (-) putative transposase
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  • CAF31860.1
 32660 - 33520 (-) hypothetical protein
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  • CAF31861.1
 33571 - 34914 (-) putative DNA-binding protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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