BGC0000700: istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
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Location: 1 - 67,904 nt. (total: 67,904 nt).
This entry is originally from NCBI GenBank AJ845083.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000700
Short description istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ845083.2
Compounds
  • istamycin
Species Streptomyces tenjimariensis [taxonomy]
References
Chemical products information
istamycin
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C14H30N4O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAH60126.1
 2 - 967 (+) putative transport permease
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  • CAH60127.1
 1011 - 1955 (+) putative adenine glycosylase
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  • CAH60128.1
 2006 - 2971 (+) putative RNA polymerase ECF-subfamily sigma factor
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  • CAH60129.1
 3220 - 3840 (+) hypothetical protein
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  • CAH60130.1
 3860 - 4564 (+) putative two-component response regulator
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  • CAH60131.1
 4693 - 6027 (+) putative two-component system sensor kinase
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  • CAH60132.1
 6068 - 6784 (-) putative peptidase
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  • CAH60133.1
 7361 - 9886 (-) putative Clp-family ATP-binding protease
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  • CAH60134.1
 10317 - 11030 (+) proline-rich protein
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  • CAH60135.1
 11513 - 11731 (-)
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  • CAH60136.1
 11752 - 13602 (-) putative plasmid transfer protein
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  • CAH60137.1
 13694 - 13954 (-) hypothetical protein
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  • CAH60138.1
 13966 - 14268 (-) hypothetical protein
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  • CAH60139.1
 14312 - 14647 (-) hypothetical protein
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  • CAH60140.1
 14644 - 15705 (-) putative conjugal transfer protein
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  • CAH60141.1
 15768 - 16049 (-) hypothetical protein
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  • CAH60142.1
 16046 - 16312 (-) hypothetical protein
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  • CAH60143.1
 16452 - 16667 (-)
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  • CAH60144.1
  • issC
 17236 - 17991 (+) putative GntR-family transcriptional regulator
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  • CAH60145.1
  • issB
 17988 - 18677 (+) putative ATP/GTP-binding protein
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  • CAH60146.1
  • issA
 18896 - 20062 (-) IssA protein
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  • CAH60147.1
  • imrA
 20325 - 20807 (+) 16S rRNA methyltransferase
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  • CAH60148.1
  • istA
 20834 - 22027 (-) IstA protein
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  • CAH60149.1
  • istD
 22189 - 22905 (-) putative amidase, AGA deacetylase
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  • CAH60150.1
  • istP
 23010 - 23831 (-) putative phosphotransferase
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  • CAH60151.1
  • istB
 23833 - 25179 (-) putative AGA 6'-aminotransferase
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  • CAH60152.1
  • istJ
 25180 - 27045 (-) putative efflux protein
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  • CAH60153.1
  • istF
 27056 - 27463 (-) IstF protein
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  • CAH60154.1
  • istU
 27460 - 28293 (-) putative N-methyltransferase
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  • CAH60155.1
  • istZ
 28339 - 29793 (-) putative N-formimidoyl istamycin A synthase
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  • CAH60156.1
  • istH
 30290 - 32068 (+) putative component of transmembrane efflux complex
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  • CAH60157.1
  • istW
 32077 - 33039 (+) putative glucose-6-phosphate 1-dehydrogenase
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  • CAH60158.1
  • istQ
 33212 - 34765 (-) putative sugar alcohol dehydrogenase
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  • CAH60159.1
  • istC
 34846 - 36060 (-) 2-deoxy-scyllo-inosose synthase
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  • CAH60160.1
  • istL3
 36122 - 37168 (-) putative metallo cofactor biosynthesis protein
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  • CAH60161.1
  • istL
 37183 - 38166 (-) putative epimerase
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  • CAH60162.2
  • istI
 38385 - 39836 (+) putative transmembrane efflux protein
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  • CAI59976.1
  • istS
 39883 - 41157 (-) putative 2-deoxy-scyllo-inosose aminotransferase
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  • CAI59977.1
  • istN
 41218 - 41991 (-) putative methyltransferase
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  • CAI59978.1
  • istX
 42006 - 42458 (-) hypothetical protein
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  • CAI59979.1
  • istM
 42761 - 44056 (+) putative NDP-D-glucosaminyltransferase
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  • CAI59980.1
  • istL2
 44248 - 45405 (+) putative (Fe-S) oxidoreductase
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  • CAI59981.1
  • istO
 45433 - 46176 (+) putative methyltransferase
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  • CAI59982.1
  • istE
 46185 - 47180 (+) putative dehydrogenase
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  • CAI59983.1
 47229 - 47723 (+) putative tRNA/mRNA methyltransferase
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  • CAI59984.1
 47725 - 49140 (-) putative transcriptional regulatory protein
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  • CAI59985.1
 49162 - 49830 (+) putative translocator
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  • CAI59986.1
 49873 - 50532 (-) putative integral membrane protein
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  • CAI59987.1
 50534 - 51037 (-) hypothetical protein
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  • CAI59988.1
 51063 - 51713 (+) putative tyrosinase co-factor protein
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  • CAI59989.1
 51700 - 52566 (+) putative tyrosinase
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  • CAI59990.1
 52657 - 53064 (-) putative small membrane protein
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  • CAI59991.1
 54071 - 54346 (-) putative membrane protein
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  • CAI59992.1
 54549 - 55097 (-) hypothetical protein
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  • CAI59993.1
 55946 - 56332 (+) hypothetical protein
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  • CAI59994.1
 56336 - 57331 (+) hypothetical protein
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  • CAI59995.1
 57309 - 58508 (+) hypothetical protein
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  • CAI59996.1
 58692 - 59861 (-) hypothetical protein
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  • CAI59997.1
 60003 - 60695 (-) hypothetical protein
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  • CAI59998.1
 60702 - 63899 (-) putative transposase
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  • CAI59999.1
 64046 - 64678 (+) putative hsp18 transcriptional regulator
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  • CAI60000.1
 64746 - 65105 (+) hypothetical protein
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  • CAI60001.1
 65243 - 65521 (+) hypothetical protein
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  • CAI60002.1
 65640 - 66224 (+) putative citrate lyase beta chain
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  • CAI60003.1
 66298 - 66807 (-) putative methyltransferase
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  • CAI60004.1
 66942 - 67391 (-) putative recombination protein
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  • CAI60005.1
 67391 - 67903 (-) putative resolvase/invertase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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