BGC0000700: istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
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Location: 1 - 67,904 nt. (total: 67,904 nt).
This entry is originally from NCBI GenBank AJ845083.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000700
Short description istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ845083.2
via
Compounds
  • istamycin
Species Streptomyces tenjimariensis [taxonomy]
References
Chemical products information
istamycin Evidence:
Copy SMILES
C14H30N4O4
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAH60126.1
2 - 967 (+) putative transport permease
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    • CAH60127.1
    1011 - 1955 (+) putative adenine glycosylase
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      • CAH60128.1
      2006 - 2971 (+) putative RNA polymerase ECF-subfamily sigma factor
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        • CAH60129.1
        3220 - 3840 (+) hypothetical protein
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          • CAH60130.1
          3860 - 4564 (+) putative two-component response regulator
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            • CAH60131.1
            4693 - 6027 (+) putative two-component system sensor kinase
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              • CAH60132.1
              6068 - 6784 (-) putative peptidase
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                • CAH60133.1
                7361 - 9886 (-) putative Clp-family ATP-binding protease
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                  • CAH60134.1
                  10317 - 11030 (+) proline-rich protein
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                    • CAH60135.1
                    11513 - 11731 (-)
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                      • CAH60136.1
                      11752 - 13602 (-) putative plasmid transfer protein
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                        • CAH60137.1
                        13694 - 13954 (-) hypothetical protein
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                          • CAH60138.1
                          13966 - 14268 (-) hypothetical protein
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                            • CAH60139.1
                            14312 - 14647 (-) hypothetical protein
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                              • CAH60140.1
                              14644 - 15705 (-) putative conjugal transfer protein
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                                • CAH60141.1
                                15768 - 16049 (-) hypothetical protein
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                                  • CAH60142.1
                                  16046 - 16312 (-) hypothetical protein
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                                    • CAH60143.1
                                    16452 - 16667 (-)
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                                      • CAH60144.1
                                      • issC
                                      17236 - 17991 (+) putative GntR-family transcriptional regulator
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                                        • CAH60145.1
                                        • issB
                                        17988 - 18677 (+) putative ATP/GTP-binding protein
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                                          • CAH60146.1
                                          • issA
                                          18896 - 20062 (-) IssA protein
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                                            • CAH60147.1
                                            • imrA
                                            20325 - 20807 (+) 16S rRNA methyltransferase
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                                              • CAH60148.1
                                              • istA
                                              20834 - 22027 (-) IstA protein
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                                                • CAH60149.1
                                                • istD
                                                22189 - 22905 (-) putative amidase, AGA deacetylase
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                                                  • CAH60150.1
                                                  • istP
                                                  23010 - 23831 (-) putative phosphotransferase
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                                                    • CAH60151.1
                                                    • istB
                                                    23833 - 25179 (-) putative AGA 6'-aminotransferase
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                                                      • CAH60152.1
                                                      • istJ
                                                      25180 - 27045 (-) putative efflux protein
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                                                        • CAH60153.1
                                                        • istF
                                                        27056 - 27463 (-) IstF protein
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                                                          • CAH60154.1
                                                          • istU
                                                          27460 - 28293 (-) putative N-methyltransferase
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                                                            • CAH60155.1
                                                            • istZ
                                                            28339 - 29793 (-) putative N-formimidoyl istamycin A synthase
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                                                              • CAH60156.1
                                                              • istH
                                                              30290 - 32068 (+) putative component of transmembrane efflux complex
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                                                                • CAH60157.1
                                                                • istW
                                                                32077 - 33039 (+) putative glucose-6-phosphate 1-dehydrogenase
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                                                                  • CAH60158.1
                                                                  • istQ
                                                                  33212 - 34765 (-) putative sugar alcohol dehydrogenase
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                                                                    • CAH60159.1
                                                                    • istC
                                                                    34846 - 36060 (-) 2-deoxy-scyllo-inosose synthase
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                                                                      • CAH60160.1
                                                                      • istL3
                                                                      36122 - 37168 (-) putative metallo cofactor biosynthesis protein
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                                                                        • CAH60161.1
                                                                        • istL
                                                                        37183 - 38166 (-) putative epimerase
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                                                                          • CAH60162.2
                                                                          • istI
                                                                          38385 - 39836 (+) putative transmembrane efflux protein
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                                                                            • CAI59976.1
                                                                            • istS
                                                                            39883 - 41157 (-) putative 2-deoxy-scyllo-inosose aminotransferase
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                                                                              • CAI59977.1
                                                                              • istN
                                                                              41218 - 41991 (-) putative methyltransferase
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                                                                                • CAI59978.1
                                                                                • istX
                                                                                42006 - 42458 (-) hypothetical protein
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                                                                                  • CAI59979.1
                                                                                  • istM
                                                                                  42761 - 44056 (+) putative NDP-D-glucosaminyltransferase
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                                                                                    • CAI59980.1
                                                                                    • istL2
                                                                                    44248 - 45405 (+) putative (Fe-S) oxidoreductase
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                                                                                      • CAI59981.1
                                                                                      • istO
                                                                                      45433 - 46176 (+) putative methyltransferase
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                                                                                        • CAI59982.1
                                                                                        • istE
                                                                                        46185 - 47180 (+) putative dehydrogenase
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                                                                                          • CAI59983.1
                                                                                          47229 - 47723 (+) putative tRNA/mRNA methyltransferase
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                                                                                            • CAI59984.1
                                                                                            47725 - 49140 (-) putative transcriptional regulatory protein
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                                                                                              • CAI59985.1
                                                                                              49162 - 49830 (+) putative translocator
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                                                                                                • CAI59986.1
                                                                                                49873 - 50532 (-) putative integral membrane protein
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                                                                                                  • CAI59987.1
                                                                                                  50534 - 51037 (-) hypothetical protein
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                                                                                                    • CAI59988.1
                                                                                                    51063 - 51713 (+) putative tyrosinase co-factor protein
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                                                                                                      • CAI59989.1
                                                                                                      51700 - 52566 (+) putative tyrosinase
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                                                                                                        • CAI59990.1
                                                                                                        52657 - 53064 (-) putative small membrane protein
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                                                                                                          • CAI59991.1
                                                                                                          54071 - 54346 (-) putative membrane protein
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                                                                                                            • CAI59992.1
                                                                                                            54549 - 55097 (-) hypothetical protein
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                                                                                                              • CAI59993.1
                                                                                                              55946 - 56332 (+) hypothetical protein
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                                                                                                                • CAI59994.1
                                                                                                                56336 - 57331 (+) hypothetical protein
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                                                                                                                  • CAI59995.1
                                                                                                                  57309 - 58508 (+) hypothetical protein
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                                                                                                                    • CAI59996.1
                                                                                                                    58692 - 59861 (-) hypothetical protein
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                                                                                                                      • CAI59997.1
                                                                                                                      60003 - 60695 (-) hypothetical protein
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                                                                                                                        • CAI59998.1
                                                                                                                        60702 - 63899 (-) putative transposase
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                                                                                                                          • CAI59999.1
                                                                                                                          64046 - 64678 (+) putative hsp18 transcriptional regulator
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                                                                                                                            • CAI60000.1
                                                                                                                            64746 - 65105 (+) hypothetical protein
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                                                                                                                              • CAI60001.1
                                                                                                                              65243 - 65521 (+) hypothetical protein
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                                                                                                                                • CAI60002.1
                                                                                                                                65640 - 66224 (+) putative citrate lyase beta chain
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                                                                                                                                  • CAI60003.1
                                                                                                                                  66298 - 66807 (-) putative methyltransferase
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                                                                                                                                    • CAI60004.1
                                                                                                                                    66942 - 67391 (-) putative recombination protein
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                                                                                                                                      • CAI60005.1
                                                                                                                                      67391 - 67903 (-) putative resolvase/invertase
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                                                                                                                                        Biosynthesis information
                                                                                                                                        Annotation changelog

                                                                                                                                        Entry version: 4

                                                                                                                                        Date
                                                                                                                                        Changes
                                                                                                                                        Submitters
                                                                                                                                        Reviewers
                                                                                                                                        Update chemical activity to schema version 2.11
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                        Entry version: 3

                                                                                                                                        Date
                                                                                                                                        Changes
                                                                                                                                        Submitters
                                                                                                                                        Reviewers
                                                                                                                                        Updated bioactivity data
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                        Entry version: 2

                                                                                                                                        Date
                                                                                                                                        Changes
                                                                                                                                        Submitters
                                                                                                                                        Reviewers
                                                                                                                                        Migrated from v1.4
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        Updated reference publication(s) (MIBiG Annotathon)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                                                                        Entry version: 1

                                                                                                                                        Date
                                                                                                                                        Changes
                                                                                                                                        Submitters
                                                                                                                                        Reviewers
                                                                                                                                        Submitted
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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