BGC0000700: istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
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Location: 1 - 67,904 nt. (total: 67,904 nt).
This entry is originally from NCBI GenBank AJ845083.2.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
History
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000700
Short description istamycin biosynthetic gene cluster from Streptomyces tenjimariensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ845083.2
Compounds
  • istamycin
Species Streptomyces tenjimariensis [taxonomy]
References
Chemical products information
Copy SMILES
istamycin
Molecular Formula C15N4O5
Chemical database entries PubCHEM  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • CAH60126.1
2 967 + putative transport permease
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  • CAH60127.1
1011 1955 + putative adenine glycosylase
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  • CAH60128.1
2006 2971 + putative RNA polymerase ECF-subfamily sigma factor
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  • CAH60129.1
3220 3840 + hypothetical protein
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  • CAH60130.1
3860 4564 + putative two-component response regulator
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  • CAH60131.1
4693 6027 + putative two-component system sensor kinase
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  • CAH60132.1
6068 6784 - putative peptidase
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  • CAH60133.1
7361 9886 - putative Clp-family ATP-binding protease
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  • CAH60134.1
10317 11030 + proline-rich protein
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  • CAH60135.1
11513 11731 -
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  • CAH60136.1
11752 13602 - putative plasmid transfer protein
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  • CAH60137.1
13694 13954 - hypothetical protein
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  • CAH60138.1
13966 14268 - hypothetical protein
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  • CAH60139.1
14312 14647 - hypothetical protein
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  • CAH60140.1
14644 15705 - putative conjugal transfer protein
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  • CAH60141.1
15768 16049 - hypothetical protein
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  • CAH60142.1
16046 16312 - hypothetical protein
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  • CAH60143.1
16452 16667 -
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  • CAH60144.1
  • issC
17236 17991 + putative GntR-family transcriptional regulator
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  • CAH60145.1
  • issB
17988 18677 + putative ATP/GTP-binding protein
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  • CAH60146.1
  • issA
18896 20062 - IssA protein
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  • CAH60147.1
  • imrA
20325 20807 + 16S rRNA methyltransferase
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  • CAH60148.1
  • istA
20834 22027 - IstA protein
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  • CAH60149.1
  • istD
22189 22905 - putative amidase, AGA deacetylase
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  • CAH60150.1
  • istP
23010 23831 - putative phosphotransferase
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  • CAH60151.1
  • istB
23833 25179 - putative AGA 6'-aminotransferase
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  • CAH60152.1
  • istJ
25180 27045 - putative efflux protein
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  • CAH60153.1
  • istF
27056 27463 - IstF protein
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  • CAH60154.1
  • istU
27460 28293 - putative N-methyltransferase
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  • CAH60155.1
  • istZ
28339 29793 - putative N-formimidoyl istamycin A synthase
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  • CAH60156.1
  • istH
30290 32068 + putative component of transmembrane efflux complex
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  • CAH60157.1
  • istW
32077 33039 + putative glucose-6-phosphate 1-dehydrogenase
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  • CAH60158.1
  • istQ
33212 34765 - putative sugar alcohol dehydrogenase
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  • CAH60159.1
  • istC
34846 36060 - 2-deoxy-scyllo-inosose synthase
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  • CAH60160.1
  • istL3
36122 37168 - putative metallo cofactor biosynthesis protein
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  • CAH60161.1
  • istL
37183 38166 - putative epimerase
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  • CAH60162.2
  • istI
38385 39836 + putative transmembrane efflux protein
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  • CAI59976.1
  • istS
39883 41157 - putative 2-deoxy-scyllo-inosose aminotransferase
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  • CAI59977.1
  • istN
41218 41991 - putative methyltransferase
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  • CAI59978.1
  • istX
42006 42458 - hypothetical protein
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  • CAI59979.1
  • istM
42761 44056 + putative NDP-D-glucosaminyltransferase
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  • CAI59980.1
  • istL2
44248 45405 + putative (Fe-S) oxidoreductase
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  • CAI59981.1
  • istO
45433 46176 + putative methyltransferase
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  • CAI59982.1
  • istE
46185 47180 + putative dehydrogenase
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  • CAI59983.1
47229 47723 + putative tRNA/mRNA methyltransferase
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  • CAI59984.1
47725 49140 - putative transcriptional regulatory protein
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  • CAI59985.1
49162 49830 + putative translocator
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  • CAI59986.1
49873 50532 - putative integral membrane protein
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  • CAI59987.1
50534 51037 - hypothetical protein
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  • CAI59988.1
51063 51713 + putative tyrosinase co-factor protein
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  • CAI59989.1
51700 52566 + putative tyrosinase
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  • CAI59990.1
52657 53064 - putative small membrane protein
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  • CAI59991.1
54071 54346 - putative membrane protein
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  • CAI59992.1
54549 55097 - hypothetical protein
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  • CAI59993.1
55946 56332 + hypothetical protein
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  • CAI59994.1
56336 57331 + hypothetical protein
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  • CAI59995.1
57309 58508 + hypothetical protein
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  • CAI59996.1
58692 59861 - hypothetical protein
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  • CAI59997.1
60003 60695 - hypothetical protein
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  • CAI59998.1
60702 63899 - putative transposase
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  • CAI59999.1
64046 64678 + putative hsp18 transcriptional regulator
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  • CAI60000.1
64746 65105 + hypothetical protein
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  • CAI60001.1
65243 65521 + hypothetical protein
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  • CAI60002.1
65640 66224 + putative citrate lyase beta chain
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  • CAI60003.1
66298 66807 - putative methyltransferase
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  • CAI60004.1
66942 67391 - putative recombination protein
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  • CAI60005.1
67391 67903 - putative resolvase/invertase
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Annotation changelog
MIBiG version Notes
2.0
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
Detailed domain annotation
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