LOCUS       BGC0000701              6021 bp    DNA     linear   BCT 28-JUL-2006
DEFINITION  Streptomyces hygroscopicus subsp. yingchengensis jinggangmycin
            biosynthetic gene cluster, complete sequence.
ACCESSION   BGC0000701
VERSION     BGC0000701
KEYWORDS    .
SOURCE      Streptomyces hygroscopicus subsp. yingchengensis
  ORGANISM  Streptomyces hygroscopicus subsp. yingchengensis
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:04:19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 6021
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..6021
                     /db_xref="taxon:228732"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces hygroscopicus subsp.
                     yingchengensis"
                     /strain="10-22"
                     /sub_species="yingchengensis"
     protocluster    1..6021
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[2122:3361]"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2123..3361
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     cand_cluster    1..6021
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..6021
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000701"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..6021
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="amglyccycl"
                     /region_number="1"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             2123..3361
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: ValA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 339.7; E-value:
                     2.7e-103)"
                     /gene_kind="biosynthetic"
                     /note="orf1"
                     /product="putative 2-epi-5-epi-valiolone synthase"
                     /protein_id="AAZ91667.1"
                     /sec_met_domain="salQ (E-value: 1.2e-198, bitscore: 647.2,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ValA (E-value: 2.3e-196, bitscore: 639.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 8.5e-67, bitscore:
                     212.7, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKQSSLSPGSRLHDYTTQDGAAWRVSALKEVSYDVMVQPRLLDP
                     ANPALADALSSGTTPARRLIVIDATVRSLYGEQLAAYLAGHDVEFHLCVIDAHESAKVM
                     ETVFEVVDAMDAFGVPRRHAPVLAMGGGVLTDIVGLAASLYRRATPYVRIPTTLIGMID
                     AGIGAKTGVNFREHKNRLGTYHPSSLTLIDPGFLATLDARHLRNGLAEILKVALVKDAE
                     LFDLLEGHGASLVEQRMQPGEGGTGGAALTVLRRAVQGMLEELQPNLWEHQLRRLVDFG
                     HSFSPSVEMAALPELLHGEAVCIDMALSSVLAHHRGLLTEAELGRVLDVMRLLHLPVLH
                     PVCTPDLMRAALADTVKHRDGWQHMPLPRGIGDAVFVNDVTQREIEAALLTLAERDRVP
                     RWRALHGAVDMGV"
     misc_feature    2123..5539
                     /note="jinggangmycin biosynthetic gene cluster"
     misc_feature    2141..2143
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS             3366..4487
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 235.3; E-value:
                     1.5e-71)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf2"
                     /product="putative adenyltransferase"
                     /protein_id="AAZ91668.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 1.2e-11, bitscore:
                     32.9, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDGVRAVLLAGGEGRRMGPLGRGRLKPLVPFGGTSRLIDFSIANV
                     HRSGLRDVLLLSQYEERRLMDDLHLVWNGRHRGFRIDFGPYDAVYRHSPGKLPEQLPER
                     TWPLERGTADALLTKAEYVFRQGDAEASEILVLHADHVYRFDYGDMIREHRASKAALTV
                     SYQRIERRYVHLFGMVEFDGDGLLTAFEEKPDDPTSDLVFAAFCLFDAATLRRYLEQLR
                     GTDWQHDISRDVIPAMLAGGELIRGYEVKSYWEDIGTVDRYHRAHRGLLRADPTLALSD
                     MPLTVAPEVPRHLVPGGPGRRASVVAADVANEGEIVSSVVYPGARIGVDAHVVDCVVLP
                     GARVPDGTHLASAIVLEDGSVQQCEAEREEVAL"
     CDS             4484..5539
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108:ROK family
                     protein (Score: 104.2; E-value: 1.5e-31)"
                     /gene_kind="other"
                     /note="orf3"
                     /product="putative 2-epi-5-epi-valiolone 7-kinase"
                     /protein_id="AAZ91669.1"
                     /transl_table=11
                     /translation="MTALTPAPCDLVVADLGGTTLRVGRITAGTSEVHDVKRVPTNGLG
                     RYGALAPQELQDRVMEQLTREIAAHLTRPGQAPAQAVAVSFAGPMTADGVVLAGPTLWG
                     GPAAPLPVADVLTQRLGLPVVAANDVTAAAWRYAAAEPEPFCLTTVSSGIGNKVFRHGE
                     IVIDQLGYGGEIGHWLVDHAEDAAPCECGGRGHLGAIASGRGALFAVRAAAAADASAFA
                     RSALAGPSGGVPEAITNEAFAAAARAGDTFARESLRRSLRPLASAVSLLFTAIGVRRYL
                     FVGGFALALGDTFLTLLGDELVRVGCFGLDEYATRAMLALGEDDDDHCLIGIGQLAAAR
                     LGAPRAVEVTA"
ORIGIN
        1 gatccgtagc tgctccttgc gcatcagcga acgaaccaca ctggtcagga agttgggccg
       61 cggaccccga tcctcccagc cgtagaccag gctcacacgc aggacaagag cggaggaggt
      121 gtcgagcagc tcccgctcgg ccgcgagctt cgcccggccg taggcgttga ccgggaaggt
      181 ctgtgctgac tccccgtagc tctcgtcctc gccggagaaa acgttgtcgg tcgacaccag
      241 caggacgggg cggccgtcca gtgcggctgc gatgttgcgg gcaccgccgt ggtgggtggc
      301 gtatgcctcc tcgggatgcg actcgcacca agtgatgtcg gaggggccgt gcacggccac
      361 gacggcatcg ggctcgacgg catccatcaa ggcagccacc tgcgggcccg aggtgacatc
      421 gacctgcttc cagcgcacac ctcggctctc ggggaggact ggggcacgcc gggagctgag
      481 cactgtctcg gcgccgagcc gggtgaggcg agcggcgatg tgcccggcaa ggtagccgga
      541 accgaggatc aggatgcggc caggcacggc aggcgccgcc gtgcctggcc ggagtacgag
      601 tggcgacgag cgaaggtcag acatgtgttt cctccggctg atgtggcggg ctgacatggc
      661 ggaaacgtgt gccgatcggg taaacgggcg tccagtgcag tcgcacacgt gggttccccg
      721 gccggtgccg ccgttgagcg cgcctgatgg ttcgtgatgc catgccacag tcacgggtgc
      781 ggtactggtg acggcgaagg tttggcaccg gctggattcg gtccgatgct cgggcgggtc
      841 ccgtgcggct tggcgatgcc ggcgaacctt tcggcgaacg ccgggttgct tcgagaatga
      901 gaccatattg ccctcgcgcc caattagggc gatcggccga tggtcctgtc cgtctccgcc
      961 gcttcttcaa cagttccgtc gagccggacg ggttatggcg tgaatccgct actcgtggac
     1021 acgaccgcaa cagcacggta cggcgacgca ggagacccgt attttgtcga tgccgctcca
     1081 ctcgacgcca gtgaagccgg cggcttattg cggcaggggc tcacgcacgg cccgacgggc
     1141 cgaaatcctg ggtacgcctg ggtgattttc tctcaagtcg gcgcccgagc agcgatagtg
     1201 catgctactg ccgctctcgc gccacccttg acggctgttg aatgcatcga tgcgggtctg
     1261 gcagtgctga ggaatgtcgc agaagtcagc atttccgctc cgagtggtcg gcactgcgga
     1321 gtttgttcct gtgcccagtc aaattcaaac cgccacacgt acacaaccag ccgggcagca
     1381 gttgcgcgct tcaggcactg caagagcatt ttcatccccg cgttaccgtg ggtgactcat
     1441 gagcttacat cttgcccatt acaagcagct ggtaactcgt tgtcaagtac acggtttttt
     1501 tggctcgatc agccctgtgg tgcttcatgt acgcgcacaa gctcaattga catgccccct
     1561 atgatccgtt ttgcaccgcg catcgacggc cagaaacggc cttggcgaca gccgtgatcg
     1621 agcattcgcg catgagacgg acatacggga ctgcatgtcc cttgacaagg tcatgtgcac
     1681 ggacttacat ctacgatcta tagatcactc accagtgagt gatccgaagc cgccgaggga
     1741 ttgccgtacc ggcagttcac cgcttgaccg cttgacgcag gcgcggcgcg cgaagagcca
     1801 gatcaggcag tggcgtcgcg tctgtggctg aacgcctcca tcaccgcaat cgaaccccat
     1861 cttccacccg acgccgctgt gccctctcct gtcacctgct gtgggacgca caacgccgcc
     1921 ggctcgccac cggtcgagcc gccgtcggaa ggagccacca cagcgtctcg cgccgtcacc
     1981 tcgtcacgcc gaccatcgca cgcgcccagt gcacatgcga gtgacgcaac gcgcgcgcca
     2041 cggccgtaac cggtggcctg ctccagcggc tgcctccccc gtccccacca gtgctcctct
     2101 tcaccacgtg aggtcgatga ccatgaccaa gcagagttcc ttatcccccg gtagccgcct
     2161 gcacgactac accacgcagg acggcgcggc ctggcgggtg agcgcgctca aggaggtgag
     2221 ctacgacgtc atggtgcagc cgcggctgct cgatccggcg aatccggcgc tcgccgacgc
     2281 cctctcgtcc gggacgacgc ctgcgcgccg gctcatcgtg atagacgcta cggtgcgctc
     2341 cctctacggc gagcagcttg ccgcctacct ggcgggccac gacgtggagt tccacctgtg
     2401 cgtcatcgac gcacacgagt cggcgaaggt catggagacc gtcttcgaag tcgtggacgc
     2461 gatggacgcc ttcggtgtgc cacggcgcca cgcaccggtg ctcgccatgg gtggcggggt
     2521 gctcacggac atcgtcggtc ttgcggcgag cctgtaccgc agggccacgc cgtacgtccg
     2581 catacccacg accctgatcg ggatgatcga cgcgggcatc ggcgccaaga caggtgtcaa
     2641 cttccgtgag cacaagaatc ggttgggcac gtatcacccc tcctcgctga ccctcatcga
     2701 tcccggcttc ctcgccacac tcgatgcccg acacctgcgc aacggtctgg cggaaatcct
     2761 gaaggtggcc ctggtcaagg atgccgaact gttcgatctg ctggaggggc acggcgcgag
     2821 cctggtcgag cagcggatgc aaccgggcga gggcgggacg ggcggtgcgg cgctcacagt
     2881 gctgcgccgg gcggtccagg gcatgctgga ggagctccag cccaatctct gggagcacca
     2941 gctgcggcgc ctggtggact tcggccactc cttctcaccc agcgtcgaga tggcggcgct
     3001 gcccgagttg ctgcacggtg aggccgtctg catcgacatg gcgctcagct cggtgctcgc
     3061 ccatcaccgt gggctactga ccgaggccga gctcggccgt gtcctcgatg tcatgcgtct
     3121 gctccacctg cctgtgctcc acccggtgtg cacgccggac ctcatgcgcg cggcgctcgc
     3181 ggacacggtc aaacaccggg acggctggca acacatgccc cttccacgcg ggatcggcga
     3241 cgccgtgttc gtgaacgacg tcactcaacg ggagatcgag gccgcgcttc tcacactcgc
     3301 cgagcgggat cgggtgccgc ggtggcgggc gctgcacggt gccgtggaca tgggggtgtg
     3361 agcgcatgga cggagtgcgt gccgtactgc tggcgggcgg cgaaggccgg cgcatggggc
     3421 cgctgggacg cggcaggctc aagccgctgg tgccgttcgg cggcacctcc cggctcatcg
     3481 atttcagcat cgccaacgtt caccggtcgg gcctgcggga cgtcctgctg ctgtcgcagt
     3541 acgaggagcg ccgcctcatg gacgatctgc acctggtctg gaacgggcgc caccgcggct
     3601 tccggataga tttcggcccc tatgacgcgg tgtaccggca ctcaccgggc aagctgcccg
     3661 agcaactgcc ggagcgtacc tggccgttgg aacgcggcac agccgacgcg ctgctcacca
     3721 aggccgagta cgtcttcagg cagggcgacg cagaggcctc ggagatcctc gtgctccacg
     3781 cggaccacgt ctaccgtttc gactacggcg acatgatccg cgagcaccgc gcgtccaagg
     3841 ccgcgctgac agtgtcgtac cagcgcatcg agcggcggta cgtgcacctt ttcggcatgg
     3901 tcgagttcga cggggacggc ctgctcacag cgttcgagga gaagcctgat gaccccacga
     3961 gcgacctggt gttcgccgcc ttctgcctct tcgacgcggc gaccctgcgg cgttacctgg
     4021 agcaactgcg cggcacggat tggcagcacg acatcagcag ggacgtcatc ccggcgatgc
     4081 tggcgggcgg cgaactcatc cgcgggtatg aggtcaagag ctactgggag gacatcggca
     4141 ccgtggaccg ctaccaccgc gcccatcgcg gactgctgcg ggctgatccg acgctcgcgt
     4201 tgagcgacat gccgctgacc gtcgcccccg aggtgccacg gcacctcgtc ccgggcgggc
     4261 ccggccggcg tgccagcgtc gtggcggccg acgtggcgaa cgagggcgag atcgtgagca
     4321 gcgtggtgta cccgggcgca cgcatcggtg ttgacgcaca cgtggtcgac tgcgtcgtgc
     4381 tgccaggcgc ccgggtaccg gacggaacac acctggcgtc ggccatcgtg ctggaggacg
     4441 gctccgtcca gcagtgcgag gcggagcggg aagaggtggc gctgtgacgg cacttacccc
     4501 cgcgccgtgt gacctcgtgg tggccgacct cggtggcacg accctgcgcg tgggccgcat
     4561 cacggcgggc acgtccgaag tgcacgacgt gaagcgagtg cccaccaacg ggctcggtcg
     4621 gtacggcgca ctcgccccgc aggagctcca ggaccgcgtc atggaacagc tgacgcggga
     4681 gatcgcggcc cacctgaccc gtccgggtca agcacccgct caggctgtcg ccgtgtcctt
     4741 cgccgggccg atgacagccg acggagtcgt cctcgccggc ccgacactgt ggggaggacc
     4801 cgcggcacca ctgcccgtcg ccgacgtgtt gacccaacgg ctgggtctgc ccgtggtcgc
     4861 ggccaacgac gtgaccgcgg cggcctggcg atacgccgct gccgagcccg agccgttctg
     4921 cctgaccacc gtgagctcgg gcatcggaaa caaggtcttc cgccatggcg agatcgtcat
     4981 cgaccagctc gggtacggag gcgagatcgg ccactggctc gtcgatcacg ctgaggacgc
     5041 cgcgccatgc gagtgcggag ggcgcggcca cctcggggcg atcgcgtcgg gacgcggcgc
     5101 cctgttcgcg gtgcgcgcgg cggcggcagc cgacgccagt gccttcgcgc gctccgcgct
     5161 ggccgggccg tcgggcggcg tgcccgaggc catcaccaac gaggcgttcg cggcggcggc
     5221 ccgagcaggc gacacgttcg cgcgggagtc gctgcgccgc tcgctgcggc ccctcgcgtc
     5281 cgcggtgagt ttgctgttca ccgcgatcgg agtgcgccgt tacctgttcg tggggggctt
     5341 cgccctcgcc ttgggcgaca ccttcctgac gttgctcggt gacgagttgg tgcgggtcgg
     5401 ctgcttcggc ttggacgagt acgcgacgcg cgccatgctc gcgctcggtg aggatgacga
     5461 cgaccactgc ctcatcggca tcggtcagtt ggcggcggcc cgcctcggcg ctccccgggc
     5521 cgtcgaggtg acggcgtgac cacgctgctc ctgggcagcg actccgtcgg cggtgcgccg
     5581 gccacggcac tggcgtgggc gagggaagca gtcgcgggca ccttcgggac ccgcccgagg
     5641 gccggcacac tcgccgccgg cgtccggtgg ggacggctcg acgtgacgcg gcccgggggc
     5701 ctcccgctgg tgccggccgg ccgcggagcc gggcgggccg tcctcgcgca cggcccgcca
     5761 cacgtcctgg tgcgagcggc caccgccgga agccgtgacg gggcatgtcg tggcggcgcg
     5821 gccggtggcg atggtccggc ggccggtgat gccgatctcc acggacaacg tcctcgacgc
     5881 agtggtctgc gcgctgtccg gcacatgacg cgtacgacac cggcgaaccc gtacgccggt
     5941 acgaaaccag cggcggaaca gtagtcgtca ggccagccgg ccctgcccgt accgcgagtc
     6001 cgcctcgtcc gcagtccgac g
//
