BGC0000705: kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus
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Location: 1 - 41,576 nt. (total: 41,576 nt).
This entry is originally from NCBI GenBank AJ628422.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000705
Short description kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ628422.2
via
Compounds
  • kanamycin
Species Streptomyces kanamyceticus [taxonomy]
References
Chemical products information
kanamycin Evidence:
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C18H36N4O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF31568.1
 2 - 1555 (+) putative sugar ABC transporter
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    • CAF31569.1
    		 1564 - 2805 (+) putative sugar ABC transporter
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      • CAF31570.1
      		 3025 - 3999 (-) putative O-methyltransferase
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        • CAF31571.1
        		 4325 - 5161 (+) putative NH3-dependent NAD(+) synthase
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          • CAF31572.1
          		 5227 - 5655 (-) hypothetical protein
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            • CAF31573.1
            		 5763 - 6485 (-) hypothetical protein
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              • CAF31574.1
              • kaoA
              		 6680 - 9178 (-) possible kanamycin regulatory protein
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                • CAF31575.1
                • kanZ
                		 9320 - 11755 (-) putative kanamycin efflux protein
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                  • CAF31576.1
                  • kanY
                  		 11959 - 12402 (-) KanY
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                    • CAF31577.1
                    • kanX
                    		 12524 - 13786 (-) putative integral membrane kanamycin efflux protein
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                      • CAF31578.1
                      • kanW
                      		 13837 - 14031 (-) possible kanamycin biosynthetic protein
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                        • CAF31579.1
                        • kanA
                        		 14067 - 14597 (+) kanamycin 6'-acetyltransferase
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                          • CAF31580.1
                          • kanG
                          		 14663 - 15784 (-) KanG
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                            • CAF31581.1
                            • kanH
                            		 15831 - 16418 (-) KanH
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                              • CAF31582.1
                              • kanI
                              		 16476 - 16958 (-) KanI
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                                • CAF31583.1
                                • kanR
                                		 17386 - 18495 (+) putative regulator of gene expression
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                                  • CAF31584.1
                                  • kanE
                                  		 18590 - 19621 (+) 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
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                                    • CAF31585.1
                                    • kanT
                                    		 19720 - 20961 (+) putative kanamycin export protein
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                                      • CAF31586.1
                                      • kanB
                                      		 20967 - 22145 (+) pyridoxalphosphate-dependent aminotransferase class III
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                                        • CAF31587.1
                                        • kanQ
                                        		 22153 - 23679 (+) oxidoreductase; putative kanamycin 6'-dehydrogenase
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                                          • CAF31588.1
                                          • kanS1
                                          		 23798 - 25081 (+) L-glutamine:2-deoxy-ketocyclitol aminotransferase
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                                            • CAF31589.1
                                            • kanC
                                            		 25123 - 26295 (+) 2-deoxy scyllo-inosose synthase
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                                              • CAF31590.1
                                              • kanD2
                                              		 26304 - 27413 (+) oxidoreductase
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                                                • CAF31591.1
                                                • kanM2
                                                		 27652 - 28818 (+) putative paromamine 6-glucosyltransferase
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                                                  • CAF31592.1
                                                  • kanN
                                                  		 28815 - 29564 (+) KanN
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                                                    • CAF31593.1
                                                    • kanS2
                                                    		 29561 - 30820 (+) putative pyridoxalphosphate-dependent aminotransferase class IV
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                                                      • CAF31594.2
                                                      • kanJ
                                                      		 30979 - 31836 (+) putative kanamycin biosynthetic protein
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                                                        • CAF31595.1
                                                        • kanK
                                                        		 31970 - 32920 (+) putative (NDP-)sugar oxidoreductase
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                                                          • CAF31596.1
                                                          • kmr
                                                          		 33046 - 33879 (+) 16S rRNA methyltransferasease
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                                                            • CAF31597.1
                                                            • kanM1
                                                            		 33962 - 35206 (+) putative 2-deoxystreptamine 4-(N-acetyl-)glucosaminyltransferase
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                                                              • CAF31598.1
                                                              • kanL
                                                              		 35265 - 36272 (+) putative kanamycin biosynthetic protein
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                                                                • CAF31599.1
                                                                • kanO
                                                                		 36307 - 36705 (+) putative kanamycin biosynthetic protein
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                                                                  • CAF31600.1
                                                                  • kanP
                                                                  		 36729 - 37400 (-) putative kanamycin biosynthetic protein
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                                                                    • CAF31601.1
                                                                    • kanD3
                                                                    		 37653 - 39434 (+) putative dehydrogenase
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                                                                      • CAF31602.1
                                                                      • kanU
                                                                      		 39547 - 40356 (+) putative regulatory protein
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                                                                        • CAI96521.1
                                                                        		 40758 - >41573 (+) putative crotony-CoA reductase
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                                                                          Biosynthesis information
                                                                          Annotation changelog

                                                                          Entry version: 2

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2019-10-16
                                                                          Migrated from v1.4
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          2019-10-16
                                                                          Updated reference publication(s) (MIBiG Annotathon)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                          Entry version: 1

                                                                          Date
                                                                          Changes
                                                                          Submitters
                                                                          Reviewers
                                                                          2015-06-12
                                                                          Submitted
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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