BGC0000709: neomycin biosynthetic gene cluster from Streptomyces fradiae ATCC 10745 = DSM 40063
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Location: 1 - 50,466 nt. (total: 50,466 nt).
This entry is originally from NCBI GenBank AJ629247.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000709
Short description neomycin biosynthetic gene cluster from Streptomyces fradiae ATCC 10745 = DSM 40063
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ629247.1
Compounds
  • neomycin
Species Streptomyces fradiae ATCC 10745 = DSM 40063 [taxonomy]
References
Chemical products information
neomycin
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C23H46N6O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF33300.1
 1 - 1635 (+) hypothetical protein
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  • CAF33301.1
 1632 - 2567 (+) putative ATPase
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  • CAF33302.1
 2581 - 7962 (+) putative multidomain-regulator
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  • CAF33303.1
 8100 - 8348 (+) putative pectinesterase (possible fragmentary and non-functional)
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  • CAF33304.1
 8501 - 9043 (+) putative integral membrane protein
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  • CAF33305.1
 8821 - 9117 (-) hypothetical protein
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  • CAF33306.1
  • aphA
 9188 - 9994 (-) aminoglycoside 3'-phosphotransferase
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  • CAF33307.1
  • neoG
 10003 - 11298 (-) possible regulator, NeoG
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  • CAF33308.1
  • neoH
 11288 - 11809 (-) possible regulator, NeoH
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  • CAF33309.1
  • neoI
 12208 - 12735 (-) possible regulator, NeoI
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  • CAF33310.1
  • neoE
 12947 - 13969 (+) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase, NeoE
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  • CAF33311.1
  • neoS
 14048 - 15322 (+) putative bifunctional L-glutamine:ketocyclitol aminotransferase I and II, NeoS
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  • CAF33312.1
  • neoC
 15493 - 16785 (+) putative 2-deoxy-scyllo-inosose synthase, NeoC
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  • CAF33313.1
  • neoM
 16938 - 18197 (+) putative UDP-NAc-glucosamine:2-deoxystreptamine 4-glycosyltransferase, NeoM
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  • CAF33314.1
  • neoT
 18185 - 20185 (+) putative ABC transporter, ATP-binding protein, NeoT
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  • CAF33315.1
  • neoU
 20182 - 21966 (+) putative ABC transporter, ATP-binding protein, NeoU
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  • CAF33316.1
  • neoQ
 22175 - 23800 (+) putative bifunctional neomycin 6'-and 6'''-dehydrogenase, NeoQ
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  • CAF33317.1
  • neoN
 23974 - 24873 (+) putative Fe-S oxidoreductase, NeoN
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  • CAF33318.1
  • neoP
 24870 - 25571 (+) putative phosphatase in neomycin pathway, NeoP
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  • CAF33319.1
  • neoX
 25568 - 25819 (+) hypothetical protein, NeoX
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  • CAF33320.1
  • neoF
 25812 - 26912 (+) putative hexosaminyltransferase II or mannosyltransferase, NeoF
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  • CAF33321.1
  • neoD
 26905 - 27744 (+) putative 2-N-acetylhexosamine deacetylase, NeoD
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  • CAF33322.1
  • neoL
 27942 - 29924 (-) putative neomycin production protein, NeoL
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  • CAF33323.1
  • neoB
 30041 - 31291 (+) putative bifunctional neomycin 6'-and 6'''-aminotransferase, NeoB
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  • CAF33324.1
  • neoA
 31440 - 35321 (+) putative neomycin production protein, NeoA
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  • CAF33325.1
  • aacC8
 35483 - 36346 (-) AacC8
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  • CAF33326.1
  • neoR
 36726 - 39386 (-) putative regulator, NeoR
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  • CAF33327.1
  • neoY
 39415 - 39636 (+) hypothetical protein, NeoY
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  • CAF33328.1
 39714 - 40235 (+) hypothetical protein
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  • CAF33329.1
 40437 - 40859 (-) hypothetical protein
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  • CAF33330.1
 41084 - 42448 (-) putative serine protease
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  • CAF33331.1
 42552 - 43502 (-) putative lysR-family regulatory protein
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  • CAF33332.1
 43828 - 46047 (+) putative isocitrate dehydrogenase
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  • CAF33333.1
 46279 - 48168 (+) putative heat shock protein HSP70
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  • CAF33334.1
 48165 - 48506 (+) hypothetical protein
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  • CAF33335.1
 48677 - 49135 (+) putative integral membrane protein
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  • CAF33336.1
 49233 - 49997 (+) hypothetical protein
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  • CAF33337.1
 50079 - 50465 (-) putative proton-dependent transporter
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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