BGC0000709: neomycin biosynthetic gene cluster from Streptomyces fradiae ATCC 10745 = DSM 40063
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Location: 1 - 50,466 nt. (total: 50,466 nt).
This entry is originally from NCBI GenBank AJ629247.1.

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core biosynthetic genes
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resistance
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000709
Short description neomycin biosynthetic gene cluster from Streptomyces fradiae ATCC 10745 = DSM 40063
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ629247.1
via
Compounds
  • neomycin
Species Streptomyces fradiae ATCC 10745 = DSM 40063 [taxonomy]
References
Chemical products information
neomycin Evidence:
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C23H46N6O13
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF33300.1
 1 - 1635 (+) hypothetical protein
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    • CAF33301.1
    		 1632 - 2567 (+) putative ATPase
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      • CAF33302.1
      		 2581 - 7962 (+) putative multidomain-regulator
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        • CAF33303.1
        		 8100 - 8348 (+) putative pectinesterase (possible fragmentary and non-functional)
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          • CAF33304.1
          		 8501 - 9043 (+) putative integral membrane protein
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            • CAF33305.1
            		 8821 - 9117 (-) hypothetical protein
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              • CAF33306.1
              • aphA
              		 9188 - 9994 (-) aminoglycoside 3'-phosphotransferase
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                • CAF33307.1
                • neoG
                		 10003 - 11298 (-) possible regulator, NeoG
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                  • CAF33308.1
                  • neoH
                  		 11288 - 11809 (-) possible regulator, NeoH
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                    • CAF33309.1
                    • neoI
                    		 12208 - 12735 (-) possible regulator, NeoI
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                      • CAF33310.1
                      • neoE
                      		 12947 - 13969 (+) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase, NeoE
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                        • CAF33311.1
                        • neoS
                        		 14048 - 15322 (+) putative bifunctional L-glutamine:ketocyclitol aminotransferase I and II, NeoS
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                          • CAF33312.1
                          • neoC
                          		 15493 - 16785 (+) putative 2-deoxy-scyllo-inosose synthase, NeoC
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                            • CAF33313.1
                            • neoM
                            		 16938 - 18197 (+) putative UDP-NAc-glucosamine:2-deoxystreptamine 4-glycosyltransferase, NeoM
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                              • CAF33314.1
                              • neoT
                              		 18185 - 20185 (+) putative ABC transporter, ATP-binding protein, NeoT
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                                • CAF33315.1
                                • neoU
                                		 20182 - 21966 (+) putative ABC transporter, ATP-binding protein, NeoU
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                                  • CAF33316.1
                                  • neoQ
                                  		 22175 - 23800 (+) putative bifunctional neomycin 6'-and 6'''-dehydrogenase, NeoQ
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                                    • CAF33317.1
                                    • neoN
                                    		 23974 - 24873 (+) putative Fe-S oxidoreductase, NeoN
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                                      • CAF33318.1
                                      • neoP
                                      		 24870 - 25571 (+) putative phosphatase in neomycin pathway, NeoP
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                                        • CAF33319.1
                                        • neoX
                                        		 25568 - 25819 (+) hypothetical protein, NeoX
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                                          • CAF33320.1
                                          • neoF
                                          		 25812 - 26912 (+) putative hexosaminyltransferase II or mannosyltransferase, NeoF
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                                            • CAF33321.1
                                            • neoD
                                            		 26905 - 27744 (+) putative 2-N-acetylhexosamine deacetylase, NeoD
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                                              • CAF33322.1
                                              • neoL
                                              		 27942 - 29924 (-) putative neomycin production protein, NeoL
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                                                • CAF33323.1
                                                • neoB
                                                		 30041 - 31291 (+) putative bifunctional neomycin 6'-and 6'''-aminotransferase, NeoB
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                                                  • CAF33324.1
                                                  • neoA
                                                  		 31440 - 35321 (+) putative neomycin production protein, NeoA
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                                                    • CAF33325.1
                                                    • aacC8
                                                    		 35483 - 36346 (-) AacC8
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                                                      • CAF33326.1
                                                      • neoR
                                                      		 36726 - 39386 (-) putative regulator, NeoR
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                                                        • CAF33327.1
                                                        • neoY
                                                        		 39415 - 39636 (+) hypothetical protein, NeoY
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                                                          • CAF33328.1
                                                          		 39714 - 40235 (+) hypothetical protein
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                                                            • CAF33329.1
                                                            		 40437 - 40859 (-) hypothetical protein
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                                                              • CAF33330.1
                                                              		 41084 - 42448 (-) putative serine protease
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                                                                • CAF33331.1
                                                                		 42552 - 43502 (-) putative lysR-family regulatory protein
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                                                                  • CAF33332.1
                                                                  		 43828 - 46047 (+) putative isocitrate dehydrogenase
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                                                                    • CAF33333.1
                                                                    		 46279 - 48168 (+) putative heat shock protein HSP70
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                                                                      • CAF33334.1
                                                                      		 48165 - 48506 (+) hypothetical protein
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                                                                        • CAF33335.1
                                                                        		 48677 - 49135 (+) putative integral membrane protein
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                                                                          • CAF33336.1
                                                                          		 49233 - 49997 (+) hypothetical protein
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                                                                            • CAF33337.1
                                                                            		 50079 - 50465 (-) putative proton-dependent transporter
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                                                                              Biosynthesis information
                                                                              Annotation changelog

                                                                              Entry version: 4

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-10-07
                                                                              Update chemical activity to schema version 2.11
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 3

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2022-09-15
                                                                              Updated bioactivity data
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 2

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2019-10-16
                                                                              Migrated from v1.4
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2019-10-16
                                                                              Updated reference publication(s) (MIBiG Annotathon)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              2019-10-16
                                                                              Updated compound(s) information (NPAtlas curation)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                              Entry version: 1

                                                                              Date
                                                                              Changes
                                                                              Submitters
                                                                              Reviewers
                                                                              2015-06-12
                                                                              Submitted
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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