BGC0000712: paromomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
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Location: 1 - 48,169 nt. (total: 48,169 nt).
This entry is originally from NCBI GenBank AJ628955.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000712
Short description paromomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AJ628955.2
Compounds
  • paromomycin
Species Streptomyces rimosus subsp. paromomycinus [taxonomy]
References
Chemical products information
paromomycin
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C23H45N5O14
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF32360.1
 1 - 242 (-) putative P450 heme thiolate protein
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  • CAF32361.1
 279 - 1520 (-) putative cytochrome P450 hydroxylase
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  • CAF32362.1
 1517 - 4849 (-) putative non-ribosomal peptide synthetase
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  • CAF32363.1
 4908 - 5384 (-) hypothetical protein
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  • CAF32364.1
 5831 - 6613 (+) hypothetical protein
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  • CAF32365.1
 6792 - 7202 (+) hypothetical protein
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  • CAF32366.1
 7286 - 7921 (+) putative polyketide cyclase /reductase
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  • CAF32367.1
 7997 - 9115 (-) putative amidinotransferase
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  • CAF32368.1
 9285 - 9794 (-) putative regulator protein
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  • CAF32369.1
 9991 - 10233 (+) putative regulator protein
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  • CAF32370.1
 10324 - 11238 (+) putative DNA-binding protein
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  • CAF32371.1
 11262 - 12077 (-) hypothetical protein
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  • CAF32372.1
  • parE
 12684 - 13703 (+) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
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  • CAF32373.1
  • parS
 13759 - 15033 (+) putative bifunctional L-glutamine:ketocyclitol aminotransferase I and II
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  • CAF32374.1
  • parC
 15102 - 16262 (+) putative 2-deoxy-scyllo-inosose synthase / cyclase
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  • CAF32375.1
  • parM
 16326 - 17579 (+) putative UDP-NAc-glucosamine:2-deoxystreptamine 4-glycosyltransferase
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  • CAF32376.1
  • parT
 17576 - 19390 (+) putative ABC transporter, ATP-binding protein
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  • CAF32377.1
  • parU
 19390 - 21276 (+) putative ABC transporter, ATP-binding protein
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  • CAF32378.1
  • parQ
 21329 - 22969 (+) putative paromomycin 6'-dehydrogenase
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  • CAF32379.1
  • parN
 23018 - 23914 (+) hypothetical protein
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  • CAF32380.1
  • parP
 23911 - 24606 (+) putative phosphatase
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  • CAF32381.1
  • parX
 24603 - 24875 (+) hypothetical protein
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  • CAF32382.1
  • parF
 24868 - 25971 (+) putative glycosyltransferase III
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  • CAF32383.1
  • parD
 25976 - 26737 (+) putative 2-N-acetylhexosamine deacetylase
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  • CAF32384.1
  • parL
 26770 - 28683 (-) hypothetical protein
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  • CAF32385.1
  • parB
 29001 - 30254 (+) putative paromomycin 6'-aminotransferase
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  • CAF32386.2
  • parA
 30305 - 34213 (+) putative paromomycin production protein
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  • CAG44621.1
  • parK
 34259 - 35626 (-) extracellular aminoglycoside phosphate phosphatase
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  • CAG44622.1
  • parI
 35834 - 36325 (+) ParI
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  • CAG44623.1
  • parR__aphA_
 36406 - 37194 (+) aminoglycoside 3'-phosphotransferase
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  • CAG44624.1
  • parY
 37279 - 37968 (-) hypothetical protein ParY
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  • CAG44625.1
  • parG
 37996 - 39198 (-) ParG
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  • CAG44626.1
  • parH
 39191 - 39745 (-) ParH
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  • CAG44627.1
  • SriL03.14c
 40697 - 40927 (-) NDP-hexose synthase (fragment)
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  • CAG44628.1
  • SriL03.13
 41695 - 44022 (+) chitinase
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  • CAG44629.1
  • SriL03.12c
 44247 - 45101 (-) SriL03.12c
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  • CAG44630.1
  • SriL03.11
 45215 - 45844 (+) SriL03.11
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  • CAG44631.1
  • SriL03.10c
 45997 - 46875 (-) SriL03.10c
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  • CAG44632.1
  • SriL03.9
 47072 - 47929 (+) SriL03.9
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  • CAG44633.1
  • SriL03.8
 48045 - >48169 (+) SriL03.8
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated reference publication(s) (MIBiG Annotathon)
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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