BGC0000712: paromomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
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Location: 1 - 48,169 nt. (total: 48,169 nt).
This entry is originally from NCBI GenBank AJ628955.2.

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core biosynthetic genes
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transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000712
Short description paromomycin biosynthetic gene cluster from Streptomyces rimosus subsp. paromomycinus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AJ628955.2
via
Compounds
  • paromomycin
Species Streptomyces rimosus subsp. paromomycinus [taxonomy]
References
Chemical products information
paromomycin Evidence:
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C23H45N5O14
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAF32360.1
 1 - 242 (-) putative P450 heme thiolate protein
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    • CAF32361.1
    		 279 - 1520 (-) putative cytochrome P450 hydroxylase
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      • CAF32362.1
      		 1517 - 4849 (-) putative non-ribosomal peptide synthetase
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        • CAF32363.1
        		 4908 - 5384 (-) hypothetical protein
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          • CAF32364.1
          		 5831 - 6613 (+) hypothetical protein
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            • CAF32365.1
            		 6792 - 7202 (+) hypothetical protein
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              • CAF32366.1
              		 7286 - 7921 (+) putative polyketide cyclase /reductase
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                • CAF32367.1
                		 7997 - 9115 (-) putative amidinotransferase
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                  • CAF32368.1
                  		 9285 - 9794 (-) putative regulator protein
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                    • CAF32369.1
                    		 9991 - 10233 (+) putative regulator protein
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                      • CAF32370.1
                      		 10324 - 11238 (+) putative DNA-binding protein
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                        • CAF32371.1
                        		 11262 - 12077 (-) hypothetical protein
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                          • CAF32372.1
                          • parE
                          		 12684 - 13703 (+) putative 3-amino-2,3-dideoxy-scyllo-inositol 1-dehydrogenase
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                            • CAF32373.1
                            • parS
                            		 13759 - 15033 (+) putative bifunctional L-glutamine:ketocyclitol aminotransferase I and II
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                              • CAF32374.1
                              • parC
                              		 15102 - 16262 (+) putative 2-deoxy-scyllo-inosose synthase / cyclase
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                                • CAF32375.1
                                • parM
                                		 16326 - 17579 (+) putative UDP-NAc-glucosamine:2-deoxystreptamine 4-glycosyltransferase
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                                  • CAF32376.1
                                  • parT
                                  		 17576 - 19390 (+) putative ABC transporter, ATP-binding protein
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                                    • CAF32377.1
                                    • parU
                                    		 19390 - 21276 (+) putative ABC transporter, ATP-binding protein
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                                      • CAF32378.1
                                      • parQ
                                      		 21329 - 22969 (+) putative paromomycin 6'-dehydrogenase
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                                        • CAF32379.1
                                        • parN
                                        		 23018 - 23914 (+) hypothetical protein
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                                          • CAF32380.1
                                          • parP
                                          		 23911 - 24606 (+) putative phosphatase
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                                            • CAF32381.1
                                            • parX
                                            		 24603 - 24875 (+) hypothetical protein
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                                              • CAF32382.1
                                              • parF
                                              		 24868 - 25971 (+) putative glycosyltransferase III
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                                                • CAF32383.1
                                                • parD
                                                		 25976 - 26737 (+) putative 2-N-acetylhexosamine deacetylase
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                                                  • CAF32384.1
                                                  • parL
                                                  		 26770 - 28683 (-) hypothetical protein
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                                                    • CAF32385.1
                                                    • parB
                                                    		 29001 - 30254 (+) putative paromomycin 6'-aminotransferase
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                                                      • CAF32386.2
                                                      • parA
                                                      		 30305 - 34213 (+) putative paromomycin production protein
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                                                        • CAG44621.1
                                                        • parK
                                                        		 34259 - 35626 (-) extracellular aminoglycoside phosphate phosphatase
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                                                          • CAG44622.1
                                                          • parI
                                                          		 35834 - 36325 (+) ParI
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                                                            • CAG44623.1
                                                            • parR__aphA_
                                                            		 36406 - 37194 (+) aminoglycoside 3'-phosphotransferase
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                                                              • CAG44624.1
                                                              • parY
                                                              		 37279 - 37968 (-) hypothetical protein ParY
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                                                                • CAG44625.1
                                                                • parG
                                                                		 37996 - 39198 (-) ParG
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                                                                  • CAG44626.1
                                                                  • parH
                                                                  		 39191 - 39745 (-) ParH
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                                                                    • CAG44627.1
                                                                    • SriL03.14c
                                                                    		 40697 - 40927 (-) NDP-hexose synthase (fragment)
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                                                                      • CAG44628.1
                                                                      • SriL03.13
                                                                      		 41695 - 44022 (+) chitinase
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                                                                        • CAG44629.1
                                                                        • SriL03.12c
                                                                        		 44247 - 45101 (-) SriL03.12c
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                                                                          • CAG44630.1
                                                                          • SriL03.11
                                                                          		 45215 - 45844 (+) SriL03.11
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                                                                            • CAG44631.1
                                                                            • SriL03.10c
                                                                            		 45997 - 46875 (-) SriL03.10c
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                                                                              • CAG44632.1
                                                                              • SriL03.9
                                                                              		 47072 - 47929 (+) SriL03.9
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                                                                                • CAG44633.1
                                                                                • SriL03.8
                                                                                		 48045 - >48169 (+) SriL03.8
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                                                                                  Biosynthesis information
                                                                                  Annotation changelog

                                                                                  Entry version: 4

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-10-07
                                                                                  Update chemical activity to schema version 2.11
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 3

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2022-09-15
                                                                                  Updated bioactivity data
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 2

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2019-10-16
                                                                                  Migrated from v1.4
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2019-10-16
                                                                                  Updated reference publication(s) (MIBiG Annotathon)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  2019-10-16
                                                                                  Updated compound(s) information (NPAtlas curation)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                                  Entry version: 1

                                                                                  Date
                                                                                  Changes
                                                                                  Submitters
                                                                                  Reviewers
                                                                                  2015-06-12
                                                                                  Submitted
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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