BGC0000714: sisomicin biosynthetic gene cluster from Micromonospora inyonensis
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Location: 1 - 46,979 nt. (total: 46,979 nt).
This entry is originally from NCBI GenBank FJ160413.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000714
Short description sisomicin biosynthetic gene cluster from Micromonospora inyonensis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: FJ160413.1
Compounds
  • sisomicin
Species Micromonospora inyonensis [taxonomy]
References
Chemical products information
sisomicin
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C19H37N5O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN38335.1
  • sis1
 2388 - 2840 (+) hypothetical protein
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  • ACN38336.1
  • sis2
 2934 - 3392 (+) putative trp-tRNA synthetase
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  • ACN38337.1
  • sis3
 3683 - 4612 (+) tRNA-ribosyltransferase
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  • ACN38338.1
  • sis4
 4620 - 5426 (+) putative ribosomal RNA-methyltransferase
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  • ACN38339.1
  • sis5
 5440 - 6693 (-) aminotransferase
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  • ACN38340.1
  • sis6
 6708 - 8423 (-) putative sugar-alcohol dehydrogenase
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  • ACN38341.1
  • sis7
 8420 - 9214 (-) putative dehydrogenase
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  • ACN38342.1
  • sis8
 9229 - 10476 (-) glycosyltransferase
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  • ACN38343.1
  • sis9
 10513 - 11334 (-) sisomicin resistance protein
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  • ACN38344.1
  • sis10
 11629 - 12891 (+) 2-deoxy-scyllo-inosose aminotransferase
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  • ACN38345.1
  • sis11
 13028 - 14212 (+) 2-deoxy-scyllo-inosose synthase
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  • ACN38346.1
  • sis12
 14205 - 15230 (+) putative NAD-dependent dehydrogenase
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  • ACN38347.1
  • sis13
 15319 - 16491 (+) putative sisomicin glycosyltransferase II
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  • ACN38348.1
  • sis14
 16493 - 18472 (+) putative sisomicin oxidoreductase
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  • ACN38349.1
  • sis15
 18472 - 19728 (+) putative L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
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  • ACN38350.1
  • sis16
 19736 - 20107 (+) GTP cyclohydrolase I
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  • ACN38351.1
  • sis17
 20200 - 21069 (-) aminoglycoside phosphotransferase
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  • ACN38352.1
  • sis18
 21084 - 22439 (-) aminotransferase
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  • ACN38353.1
  • sis19
 23239 - 23751 (-) hypothetical protein
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  • ACN38354.1
  • sis20
 23798 - 24730 (-) putative WD-repeat-containing protein
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  • ACN38355.1
  • sis21
 24943 - 26349 (-) putative transmembrane efflux protein
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  • ACN38356.1
  • sis22
 26534 - 27544 (-) 2-deoxy-scyllo-inosamine dehydrogenase
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  • ACN38357.1
  • sis23
 28167 - 29543 (+) putative cation antiporter
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  • ACN38358.1
  • sis24
 29692 - 30402 (+) transcription regulator related protein
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  • ACN38359.1
  • sis25
 30399 - 31046 (+) putative sisomicin production protein
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  • ACN38360.1
  • sis26
 31501 - 34962 (-) putative sisomicin exporter
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  • ACN38361.1
  • sis27
 34959 - 36911 (-) putative sisomicin exporter
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  • ACN38362.1
  • sis28
 37480 - 38475 (-) predicted methyltransferase
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  • ACN38363.1
  • sis29
 38665 - 39429 (+) putative sisomicin production protein
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  • ACN38364.1
  • sis30
 39426 - 40388 (+) putative sisomicin methyltransferase
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  • ACN38365.1
  • sis31
 40495 - 40980 (-) activator of Hsp90 ATPase 1 family protein
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  • ACN38366.1
  • sis32
 40984 - 41328 (-) ArsR family transcriptional regulator
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  • ACN38367.1
  • sis33
 41391 - 42056 (+) putative serine repeat antigen
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  • ACN38368.1
  • sis34
 42176 - 43483 (-) putative two-component system histidine kinase
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  • ACN38369.1
  • sis35
 43480 - 44175 (-) putative two-component system response regulator
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  • ACN38370.1
  • sis36
 44279 - 44722 (+) putative secreted serine protease
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  • ACN38371.1
  • sis37
 44976 - 45713 (-) short-chain dehydrogenase/reductase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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