BGC0000714: sisomicin biosynthetic gene cluster from Micromonospora inyonensis
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 46,979 nt. (total: 46,979 nt).
This entry is originally from NCBI GenBank FJ160413.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000714
Short description sisomicin biosynthetic gene cluster from Micromonospora inyonensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
FJ160413.1
via
Compounds
  • sisomicin
Species Micromonospora inyonensis [taxonomy]
References
Chemical products information
sisomicin Evidence:
Copy SMILES
C19H37N5O7
Chemical database entries
NPAtlas
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACN38335.1
  • sis1
 2388 - 2840 (+) hypothetical protein
    copy AA seq
    copy Nt seq
    • ACN38336.1
    • sis2
    		 2934 - 3392 (+) putative trp-tRNA synthetase
      copy AA seq
      copy Nt seq
      • ACN38337.1
      • sis3
      		 3683 - 4612 (+) tRNA-ribosyltransferase
        copy AA seq
        copy Nt seq
        • ACN38338.1
        • sis4
        		 4620 - 5426 (+) putative ribosomal RNA-methyltransferase
          copy AA seq
          copy Nt seq
          • ACN38339.1
          • sis5
          		 5440 - 6693 (-) aminotransferase
            copy AA seq
            copy Nt seq
            • ACN38340.1
            • sis6
            		 6708 - 8423 (-) putative sugar-alcohol dehydrogenase
              copy AA seq
              copy Nt seq
              • ACN38341.1
              • sis7
              		 8420 - 9214 (-) putative dehydrogenase
                copy AA seq
                copy Nt seq
                • ACN38342.1
                • sis8
                		 9229 - 10476 (-) glycosyltransferase
                  copy AA seq
                  copy Nt seq
                  • ACN38343.1
                  • sis9
                  		 10513 - 11334 (-) sisomicin resistance protein
                    copy AA seq
                    copy Nt seq
                    • ACN38344.1
                    • sis10
                    		 11629 - 12891 (+) 2-deoxy-scyllo-inosose aminotransferase
                      copy AA seq
                      copy Nt seq
                      • ACN38345.1
                      • sis11
                      		 13028 - 14212 (+) 2-deoxy-scyllo-inosose synthase
                        copy AA seq
                        copy Nt seq
                        • ACN38346.1
                        • sis12
                        		 14205 - 15230 (+) putative NAD-dependent dehydrogenase
                          copy AA seq
                          copy Nt seq
                          • ACN38347.1
                          • sis13
                          		 15319 - 16491 (+) putative sisomicin glycosyltransferase II
                            copy AA seq
                            copy Nt seq
                            • ACN38348.1
                            • sis14
                            		 16493 - 18472 (+) putative sisomicin oxidoreductase
                              copy AA seq
                              copy Nt seq
                              • ACN38349.1
                              • sis15
                              		 18472 - 19728 (+) putative L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose aminotransferase
                                copy AA seq
                                copy Nt seq
                                • ACN38350.1
                                • sis16
                                		 19736 - 20107 (+) GTP cyclohydrolase I
                                  copy AA seq
                                  copy Nt seq
                                  • ACN38351.1
                                  • sis17
                                  		 20200 - 21069 (-) aminoglycoside phosphotransferase
                                    copy AA seq
                                    copy Nt seq
                                    • ACN38352.1
                                    • sis18
                                    		 21084 - 22439 (-) aminotransferase
                                      copy AA seq
                                      copy Nt seq
                                      • ACN38353.1
                                      • sis19
                                      		 23239 - 23751 (-) hypothetical protein
                                        copy AA seq
                                        copy Nt seq
                                        • ACN38354.1
                                        • sis20
                                        		 23798 - 24730 (-) putative WD-repeat-containing protein
                                          copy AA seq
                                          copy Nt seq
                                          • ACN38355.1
                                          • sis21
                                          		 24943 - 26349 (-) putative transmembrane efflux protein
                                            copy AA seq
                                            copy Nt seq
                                            • ACN38356.1
                                            • sis22
                                            		 26534 - 27544 (-) 2-deoxy-scyllo-inosamine dehydrogenase
                                              copy AA seq
                                              copy Nt seq
                                              • ACN38357.1
                                              • sis23
                                              		 28167 - 29543 (+) putative cation antiporter
                                                copy AA seq
                                                copy Nt seq
                                                • ACN38358.1
                                                • sis24
                                                		 29692 - 30402 (+) transcription regulator related protein
                                                  copy AA seq
                                                  copy Nt seq
                                                  • ACN38359.1
                                                  • sis25
                                                  		 30399 - 31046 (+) putative sisomicin production protein
                                                    copy AA seq
                                                    copy Nt seq
                                                    • ACN38360.1
                                                    • sis26
                                                    		 31501 - 34962 (-) putative sisomicin exporter
                                                      copy AA seq
                                                      copy Nt seq
                                                      • ACN38361.1
                                                      • sis27
                                                      		 34959 - 36911 (-) putative sisomicin exporter
                                                        copy AA seq
                                                        copy Nt seq
                                                        • ACN38362.1
                                                        • sis28
                                                        		 37480 - 38475 (-) predicted methyltransferase
                                                          copy AA seq
                                                          copy Nt seq
                                                          • ACN38363.1
                                                          • sis29
                                                          		 38665 - 39429 (+) putative sisomicin production protein
                                                            copy AA seq
                                                            copy Nt seq
                                                            • ACN38364.1
                                                            • sis30
                                                            		 39426 - 40388 (+) putative sisomicin methyltransferase
                                                              copy AA seq
                                                              copy Nt seq
                                                              • ACN38365.1
                                                              • sis31
                                                              		 40495 - 40980 (-) activator of Hsp90 ATPase 1 family protein
                                                                copy AA seq
                                                                copy Nt seq
                                                                • ACN38366.1
                                                                • sis32
                                                                		 40984 - 41328 (-) ArsR family transcriptional regulator
                                                                  copy AA seq
                                                                  copy Nt seq
                                                                  • ACN38367.1
                                                                  • sis33
                                                                  		 41391 - 42056 (+) putative serine repeat antigen
                                                                    copy AA seq
                                                                    copy Nt seq
                                                                    • ACN38368.1
                                                                    • sis34
                                                                    		 42176 - 43483 (-) putative two-component system histidine kinase
                                                                      copy AA seq
                                                                      copy Nt seq
                                                                      • ACN38369.1
                                                                      • sis35
                                                                      		 43480 - 44175 (-) putative two-component system response regulator
                                                                        copy AA seq
                                                                        copy Nt seq
                                                                        • ACN38370.1
                                                                        • sis36
                                                                        		 44279 - 44722 (+) putative secreted serine protease
                                                                          copy AA seq
                                                                          copy Nt seq
                                                                          • ACN38371.1
                                                                          • sis37
                                                                          		 44976 - 45713 (-) short-chain dehydrogenase/reductase
                                                                            copy AA seq
                                                                            copy Nt seq
                                                                            Biosynthesis information
                                                                            Annotation changelog

                                                                            Entry version: 4

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-10-07
                                                                            Update chemical activity to schema version 2.11
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 3

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2022-09-15
                                                                            Updated bioactivity data
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 2

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2019-10-16
                                                                            Migrated from v1.4
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            2019-10-16
                                                                            Updated compound(s) information (NPAtlas curation)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                            Entry version: 1

                                                                            Date
                                                                            Changes
                                                                            Submitters
                                                                            Reviewers
                                                                            2015-06-12
                                                                            Submitted
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                            Similar known gene clusters from MIBiG 4.0
                                                                            Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                                                                            Click on reference genes to show details of similarities to genes within the current region.
                                                                            Click on an accession to open that entry in the MiBIG database.