LOCUS       BGC0000714             46979 bp    DNA     linear   BCT 09-OCT-2009
DEFINITION  Micromonospora inyonensis strain TS388 sisomicin biosynthesis gene
            cluster, partial sequence.
ACCESSION   BGC0000714
VERSION     BGC0000714
KEYWORDS    .
SOURCE      Micromonospora inyonensis
  ORGANISM  Micromonospora inyonensis
            Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
            Micromonospora.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:22:58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 46979
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..46979
                     /db_xref="taxon:47866"
                     /mol_type="genomic DNA"
                     /organism="Micromonospora inyonensis"
                     /strain="TS388"
     misc_feature    <1..>46979
                     /note="sisomicin biosynthesis gene cluster"
     subregion       1..46979
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000714"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..46979
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="2dos"
                     /region_number="1"
                     /rules="((DOIS or DHQ_synthase or ValA or salQ) and
                     DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /subregion_numbers="1"
                     /tool="antismash"
     rRNA            133..1649
                     /product="16S ribosomal RNA"
     protocluster    1629..37544
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[11628:27544]"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /neighbourhood="10000"
                     /product="2dos"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      11629..27544
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /neighbourhood="10000"
                     /product="2dos"
                     /protocluster_number="1"
     cand_cluster    1629..37544
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((DOIS or DHQ_synthase or ValA or salQ)
                     and DegT_DnrJ_EryC1 and (LipV or ADSI-DH or cds(ADH_N and
                     ADH_zinc_N)))"
                     /kind="single"
                     /product="2dos"
                     /protoclusters="1"
                     /tool="antismash"
     gene            2388..2840
                     /gene="sis1"
     CDS             2388..2840
                     /codon_start=1
                     /gene="sis1"
                     /product="hypothetical protein"
                     /protein_id="ACN38335.1"
                     /transl_table=11
                     /translation="MVRDAAMSSAWIQRNPVPSPSPTVPDDHARESFQMATANLGQIAQ
                     VQNPTPTRNNDHPRDNTMADEYASAAVTPALITPAPPPRAPGHRGSVVRASSFPPVGVD
                     ASVDLPGDAVPHTPATRSGDGRERLLDVLRARGLRFRDGARWQSAL"
     gene            2934..3392
                     /gene="sis2"
     CDS             2934..3392
                     /codon_start=1
                     /gene="sis2"
                     /product="putative trp-tRNA synthetase"
                     /protein_id="ACN38336.1"
                     /transl_table=11
                     /translation="MSAAQMLTGDRPTGRLHLGHYVGSIANRVRLHQRYESFFIIADLH
                     MLTTRNTREDISRVAGNAREMVERLAVALNRFLDPMRERRARFAAERGLVDQLIADGTE
                     RTRQEVRRTLAEVRRAMGLTAAYQQIRRRAERSRRKADAPATAGTGGA"
     gene            3683..4612
                     /gene="sis3"
     CDS             3683..4612
                     /codon_start=1
                     /gene="sis3"
                     /product="tRNA-ribosyltransferase"
                     /protein_id="ACN38337.1"
                     /transl_table=11
                     /translation="MAWDGVIVSDSGGFQVLSLIRKQGKTGAIRSNGVTFQESPTAKKI
                     VLTPEKVIEWQFGLRSDVVVALDDCTGPEDSPAEQLASTERTIRWFRQARKAYDLQCRQ
                     RRSGEPPLLVGVVQGGTDPELRQRCVDALVESGAQGFGFGSWPLSAEGELEREMFALLS
                     RITPPDAPLFALGVGRPEHLVSLCELDMRWVFDCTIPTRDARHGRLYSFVPEIADRLLT
                     PDRSFYQNVYILDEENSRKDEPICATCDCPTCRRYSRSYLHHLFRVKDGLADRLATLHN
                     LRFYTRLLEMIRAGRMARPGLGEPARVG"
     gene            4620..5426
                     /gene="sis4"
     CDS             4620..5426
                     /codon_start=1
                     /gene="sis4"
                     /gene_functions="resistance (resist) ArmA_Rmt (Score:
                     115.6; E-value: 1.6e-35)"
                     /gene_kind="resistance"
                     /product="putative ribosomal RNA-methyltransferase"
                     /protein_id="ACN38338.1"
                     /transl_table=11
                     /translation="MTVSPAVEKVIVRLTSAAKYRDVHPETIADLVRREGRATGDAAEL
                     ERLVRARLHKVAALHLLTARPAALRRALDRADLDDPQARREWCRQVLAGHFCTAERLPD
                     LDTFYPTLFGLVPPPETVADIACALNPFTLPWMREVSDARYVGYDFNATFVALGNAFLA
                     RTYPESEIRHEEVLTDGHQVSADLALLLKTYHCMEGRRPGAGLALVDRLACWHVVVSFP
                     TRAMNGRAAVFVPRHVEELAELARDRGWRWSRATLPSEDLVAIDKG"
     gene            complement(5440..6693)
                     /gene="sis5"
     CDS             complement(5440..6693)
                     /NRPS_PKS="Domain: Aminotran_3 (29-317). E-value: 2.7e-12.
                     Score: 38.2. Matches aSDomain:
                     nrpspksdomains_sis5_Aminotran_3.1"
                     /codon_start=1
                     /gene="sis5"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 231.2;
                     E-value: 3.5e-70)"
                     /gene_kind="biosynthetic-additional"
                     /product="aminotransferase"
                     /protein_id="ACN38339.1"
                     /sec_met_domain="Aminotran_3 (E-value: 8.6e-16, bitscore:
                     48.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIDIGAGKLLAQEPTCPRDADGRPRVFIEGSGAYLTDPDGRRWI
                     DFDNARGSVILGHGDEEVAEAIARAARGRSGVGTAWSPVLDSLLGQLQEVCGGDVVGLY
                     RTGTAALRSVTCAVRDARERSIILSSGYHGYDPMWHCDEPFAPNQHGVVEFLFDLDVLA
                     EWLSRPEQVAAVVVSPDHMHLGERWYTEFTRLTKEADVPVIADEVKVGLRYRAGLSTHL
                     LDPAVWIVAKCLANGSPVAAVGGDAHLLAALEDVSFTSYFEPTALAAATTTLRRMATGQ
                     PQQAIRAAGDRFIAHTRAAFVGAGVPIDLAGNGNLFQFVCADDEVQDAFHAAAADEGLL
                     FFEGDNQTPSTAFTDEVVEDACGRIDQVAATLAGLFTGRELTEESWYASAWGAMDGLAD
                     RPRTREETTAIVERLWED"
     aSDomain        complement(5743..6606)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis5_Aminotran_3.1"
                     /evalue="2.70E-12"
                     /label="sis5_Aminotran_3.1"
                     /locus_tag="sis5"
                     /protein_end="317"
                     /protein_start="29"
                     /score="38.2"
                     /tool="antismash"
                     /translation="EGSGAYLTDPDGRRWIDFDNARGSVILGHGDEEVAEAIARAARGR
                     SGVGTAWSPVLDSLLGQLQEVCGGDVVGLYRTGTAALRSVTCAVRDARERSIILSSGYH
                     GYDPMWHCDEPFAPNQHGVVEFLFDLDVLAEWLSRPEQVAAVVVSPDHMHLGERWYTEF
                     TRLTKEADVPVIADEVKVGLRYRAGLSTHLLDPAVWIVAKCLANGSPVAAVGGDAHLLA
                     ALEDVSFTSYFEPTALAAATTTLRRMATGQPQQAIRAAGDRFIAHTRAAFVGAGVPIDL
                     AGNGNLF"
     gene            complement(6708..8423)
                     /gene="sis6"
     CDS             complement(6708..8423)
                     /codon_start=1
                     /gene="sis6"
                     /product="putative sugar-alcohol dehydrogenase"
                     /protein_id="ACN38340.1"
                     /transl_table=11
                     /translation="MTGRSRRDPKAGRHADPTREVLISVSADLSTGHEDVTARLRYGPE
                     PTADDTARVADVCVIGSGASGAITAWALQRAGLDVVIVEQGPFVDPWVSYDDVETIAET
                     AWIRQDSGVWEKSGNPWSTCNVGGGTVFFGGAAFRYRPVDFDAEARLGRSDLPLRWPWT
                     VEEIDPYYALVESALGIAGGGHDPSLPSDPAYPMPPVETTVEGAVIAAAARSLGLNPFP
                     TPLAIASEPYQGRLACAGKRPCISNRCDRGAKGDAVTVFLDPARKAGLRLFAGLKAVRL
                     LRRDAISVDGVECVRVDNGNRHVIRARHVVVAGNAIQSAALLLRSTDDLSPQGLGNDHD
                     MVGRGLCFKMSGYVQGYRRTDVPTTSREDRVAGPGPFSTAAITDYYTADDAPGGLGGLI
                     IESQPEESLRLRPDEQIIRLECLVPDQPRADNRVTLGRGVDRFGLPDVVMDYSPHPRDR
                     ARLEYLQRRAEEILRAAGCELTWRESSYFWMGSTHLHGTCRAGTNPRTSVTDPDGRVHG
                     LTNLMVVDGGVMPYPGGVNPTLTIQSLALRMAHQLLRREFGIESGFSSPPVGTE"
     gene            complement(8420..9214)
                     /gene="sis7"
     CDS             complement(8420..9214)
                     /NRPS_PKS="Domain: PKS_KR (14-125). E-value: 3.6e-07.
                     Score: 22.1. Matches aSDomain:
                     nrpspksdomains_sis7_PKS_KR.1"
                     /codon_start=1
                     /gene="sis7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     163.8; E-value: 8.5e-50)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative dehydrogenase"
                     /protein_id="ACN38341.1"
                     /transl_table=11
                     /translation="MDTAPASPDTTPAGGHVLVTGGNRGLGLATATLLADAGWSVLLGC
                     RDDRRGAAAATALRRRGGRAVHVPLDVTSPASIAAAADLVADHTGGRLAGLVNNAGVFL
                     DERDADLESVTAEAVHELLTVNAVGPLLVTRAVLPLLRAAGGAAVVNVTADDADPATAD
                     GEATGYRMAKAALNIMTVNLAVALREQDVVVNAVDPGWIPTDMGGPEAPDDTSAAARLV
                     AWAVTAARRHGTTGQVLTVRQPPDALRAEPVTVGAPPHGQPQ"
     aSDomain        complement(8840..9172)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis7_PKS_KR.1"
                     /evalue="3.60E-07"
                     /label="sis7_PKS_KR.1"
                     /locus_tag="sis7"
                     /protein_end="125"
                     /protein_start="14"
                     /score="22.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="GHVLVTGGNRGLGLATATLLADAGWSVLLGCRDDRRGAAAATALR
                     RRGGRAVHVPLDVTSPASIAAAADLVADHTGGRLAGLVNNAGVFLDERDADLESVTAEA
                     VHELLTV"
     CDS_motif       complement(9101..9163)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sis7_0001"
                     /evalue="3.00E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="sis7"
                     /protein_end="38"
                     /protein_start="17"
                     /score="16.7"
                     /tool="antismash"
                     /translation="LVTGGNRGLGLATATLLADAG"
     gene            complement(9229..10476)
                     /gene="sis8"
     CDS             complement(9229..10476)
                     /codon_start=1
                     /gene="sis8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 252.5;
                     E-value: 1.3e-76)"
                     /gene_kind="biosynthetic-additional"
                     /product="glycosyltransferase"
                     /protein_id="ACN38342.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 8.2e-29,
                     bitscore: 91.7, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLRLTPFFHHDYVDHWPAEFDPVGGMQVQILALSRSLARAGVD
                     QLVLTLGFPGLPPTKQIEPGLTVRIARMSLPQIRSEITGLVGLGQAWLIGTIRECLRLR
                     RGDWRPDLVHVHADGQIWPLVAGRIAARILGVPYVLTLHCSRLSVYQPMSTVDAMAHRL
                     VTQAERQALRSATRVTTLTARTADVVSAAAGLDRSAIVVNPDAVEITPATEAGTTAFAQ
                     RYGLTGRRPLIGYIGRVAHEKGWPDLLRLAELLDDLSPTFLVVGDGPQRERMEKEIAEI
                     GRAHQFVVTGFLPHDQVPAALALVDTLVMPSIHEELGGSAIEAIMAGTPVAAYAVGGLR
                     STIGSACPDLLTEPGDVRGLAEVVRRVLADRDAVVARIHAAQTTTASTFDVAATRDRML
                     DCYRAALTGAGAASGK"
     gene            complement(10513..11334)
                     /gene="sis9"
     CDS             complement(10513..11334)
                     /codon_start=1
                     /gene="sis9"
                     /gene_functions="resistance (resist) ArmA_Rmt (Score:
                     191.4; E-value: 1.2e-58)"
                     /gene_kind="resistance"
                     /product="sisomicin resistance protein"
                     /protein_id="ACN38343.1"
                     /transl_table=11
                     /translation="MTTSTGDDRIDQIQQAITKSRRYQTVAPATVRRLARAALVASRGD
                     VPDAVKRTKRGLHEIYGAFLPPSAPNYTALLRQLDTAVEAGGEAVRSALSRAMSVHMST
                     RERLPHLDEFYREIFRHVPRPNTLRDLACGLNPLAAPWMGLSDETVYVASDIDARLMDF
                     VGAALTRLGVAHRTSVVDLLEARLDEPADVTLLLKTLPCLETQQRGSGWEVIDIVNSPI
                     IVVTFPTKSLGQRSKGMFQNYSQSFESQASERSCRIQRLEIGNELIYVIQK"
     gene            11629..12891
                     /gene="sis10"
     CDS             11629..12891
                     /NRPS_PKS="Domain: Aminotran_1_2 (24-179). E-value: 9e-11.
                     Score: 33.3. Matches aSDomain:
                     nrpspksdomains_sis10_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="sis10"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     383.7; E-value: 1.6e-116)"
                     /gene_kind="biosynthetic"
                     /product="2-deoxy-scyllo-inosose aminotransferase"
                     /protein_id="ACN38344.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 9.4e-107,
                     bitscore: 348.6, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLLAVNGGSPIRSQQWPLWPAPAPGALDALNEVLHSGRWAISGP
                     YQGKQSFERRFAAAFAEFHGIGHCVPTSSGTASLMVALEACGVGAGDEVIIPGLTWVAN
                     ASTVAGVNAVPVPVDVDPRTLCLDPAAVERAITPRTAAIVVVHLYSAVADLDALTAIAE
                     RHDIPLIEDCAQAHGARYRDRRVGTFGAFGTFSMQHSKVLTSGEGGAVITGDPALSRRA
                     EHLRADGRTYTPDEPAVGEMELAQTAELMGSNRCLSEFQAALLLAQLELLDEQNDRRRA
                     NAALLDEGLGALGIQPQVSSPGTTERTYYEWAGRISDDGIGQIGVERIAATVAAELSGA
                     AIYASYPPMNHNRLYRPATRSRFNGVPGLDLTGYPLPVAEDAGQRVVTIHHSALLGDES
                     DMKDIVRAFEKVFTNHRELRG"
     aSDomain        11701..12165
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis10_Aminotran_1_2.1"
                     /evalue="9.00E-11"
                     /label="sis10_Aminotran_1_2.1"
                     /locus_tag="sis10"
                     /protein_end="179"
                     /protein_start="24"
                     /score="33.3"
                     /tool="antismash"
                     /translation="PGALDALNEVLHSGRWAISGPYQGKQSFERRFAAAFAEFHGIGHC
                     VPTSSGTASLMVALEACGVGAGDEVIIPGLTWVANASTVAGVNAVPVPVDVDPRTLCLD
                     PAAVERAITPRTAAIVVVHLYSAVADLDALTAIAERHDIPLIEDCAQAHGA"
     gene            13028..14212
                     /gene="sis11"
     CDS             13028..14212
                     /codon_start=1
                     /gene="sis11"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DHQ_synthase"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DOIS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183:3-dehydroquinate synthase (Score: 337.9; E-value:
                     9.6e-103)"
                     /gene_kind="biosynthetic"
                     /product="2-deoxy-scyllo-inosose synthase"
                     /protein_id="ACN38345.1"
                     /sec_met_domain="DOIS (E-value: 8.9e-176, bitscore: 575.3,
                     seeds: 17, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 2.7e-72, bitscore:
                     234.3, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEVEIRLGAVRYPFRLGTDCLGAIVEDLVAMSASRLLIVCDSNTG
                     PLFGAELVERLSPRVPANLLIHRAGEPYKDLQAVSTLAESALQLGADRASVVVAVGGGV
                     IGNIAGLMAALLFRGIRLVHVPTSLIAMSDSVLSLKQAVNASVGKNLVGTFYAPESVLA
                     DTAMLRSLPFRETVSGLCEVVKNSLAIRPSMIEMLRTSLRQDGCYDDKTMYQIISESIL
                     AKASVTEDDMHECRAGLVLEYGHTVGHAIEYTASGGLSHGQAIGLGMVVAAEVSRRLGH
                     LDDRAVALHRELLTRAGAMVTIPEEVDLDEVMHRLRFDNKRGYLSDPAESSAMVLLGGL
                     GQPLWQDGRPLVSVPMALVGEVINEIACPELPNFELVAPAQGERVPDTVGAADG"
     gene            14205..15230
                     /gene="sis12"
     CDS             14205..15230
                     /codon_start=1
                     /gene="sis12"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 246.1; E-value: 1e-74)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative NAD-dependent dehydrogenase"
                     /protein_id="ACN38346.1"
                     /transl_table=11
                     /translation="MVERLGVAVVGGGFMGGVHAEVLTADPRVDLRWVVDRDERVGTEL
                     ATRFGARATATLDEALADDAVRLVVVATPAATHEPIAARVIAAGRHVLVEKPLVLSTGH
                     ARQLAAAARERGVTLAHGGNFVYAPKFVRARELAADRDALGTVHSVRVAFRTSGPDTDW
                     FRSKATAGGGALTDLGWHAVELCRWMLGKPAIRSVTACTRQLSAAGDVEDQGVVLIEFA
                     DGAIGQCDVSWVCPGGEQLTVEVIGTEGLVTADLWQGMGVEVYTNTKFGAVWEPNQGWL
                     RPEWEWIRNSGYVHQDRQVVDAVLEGRPMEHTPDDAVAIVEALEAAYRSAAGGRKVETN
                     A"
     gene            15319..16491
                     /gene="sis13"
     CDS             15319..16491
                     /codon_start=1
                     /gene="sis13"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 273.9;
                     E-value: 4.2e-83)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative sisomicin glycosyltransferase II"
                     /protein_id="ACN38347.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 3e-41, bitscore:
                     132.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGMHVLGHAIVTEMGRRGFPQRVLTMAPPGVPKDLQIAPNVTVH
                     ARRLPVLPIPSKLEGYFGLVGAWAKASLLYVVRNKEQLKREIGIVHAHCDGSGSAPAYA
                     YAAAQVLDVPIVSHIYSCRSLTQHPTTVFERVADPVAKSAEKYVIQHSGAVLTLSDKVR
                     ERIRDELHVPDDRVHRLAHLVTDNFVGHDTPERREELRQRFGLTDDKPTVLYVGRISSE
                     KGVDWFVKAAAEIAKRRDCRFLIAGDGPQRGDIEALARQLGVADKLVITGFLLPEYIPS
                     IISLSTLAVLPSQYEELGVVVLEYMMMKRPVVAHDVSGVHKLVEHMKTGVLVPPFDPPK
                     LADAIEMVLDDPDLARRLADAAEPIPQREYSLASAGERLEAIYLSLMEES"
     gene            16493..18472
                     /gene="sis14"
     CDS             16493..18472
                     /codon_start=1
                     /gene="sis14"
                     /gene_functions="other (smcogs) SMCOG1277:Radical SAM
                     domain protein (Score: 136.3; E-value: 2.2e-41)"
                     /gene_kind="other"
                     /product="putative sisomicin oxidoreductase"
                     /protein_id="ACN38348.1"
                     /transl_table=11
                     /translation="MTVTSKIVTGVAFPPSLLAETPPISVATLTAYLRDKGMPARGLDL
                     NADFNEYLLNRVELEQVQGPENSHEFTQPFIKQFFLNHITGNYFAETNFEQWELQQQCQ
                     VAPESLSIWDPPFPFSYCEFLSILRDEPERVAKLVRDPDANIYHAFYHEKVAGQAAELG
                     MMGFSIMGYNQVIPALTLGYLMKQENPDLYICWGGPWVTSFADMLIPRLEACPELGDLI
                     DALVVREGEEPLLKMAEALSRGERPVGIPGGCKPMSEQSVLDTKPVGRKLLLEMSKPRE
                     NVPNTHWRTEDGTYERSGDISWVADMNQIPTPDYSDFDLSLYTTFREGQGSLVLQGSRS
                     CYYMKCSFCNAITNFAPWSYRERSTENIEKDIDTFLELYPGVVHFDFADAVFPAKRLVE
                     IADFFIEKKRPELFWEVDVRFEGNIDKAVLTKMRDSQGKLRFGLETANERLLDLVRKGN
                     RMDVVHRLLQDSRELGYKPFLMTIVGLPTEERNEAEELYEFLSEYHDTVTYQIADFIVE
                     RNSPIQLRPDEYGIHIEDDEQQSFHHNLHFTRRAGYSDEEAQEVYRDILVRTMQRFKGA
                     REVDVEQERSRVAPDDSVYRLSLRAGSFALENYWVKHNNLPFEGLVPIGYKVQQQWTDM
                     TNKGTVFEIDPDIALGALAGAGSR"
     gene            18472..19728
                     /gene="sis15"
     CDS             18472..19728
                     /NRPS_PKS="Domain: Aminotran_1_2 (46-177). E-value:
                     2.1e-08. Score: 25.5. Matches aSDomain:
                     nrpspksdomains_sis15_Aminotran_1_2.1"
                     /codon_start=1
                     /gene="sis15"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     355; E-value: 8.4e-108)"
                     /gene_kind="biosynthetic"
                     /product="putative
                     L-glutamine:3-amino-2,3-dideoxy-scyllo-inosose
                     aminotransferase"
                     /protein_id="ACN38349.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.6e-94,
                     bitscore: 308.4, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEKLAILGGDPVRQRPWPEWPHVGPADVERLRGVIESRNLGGIP
                     FPNTLHQQFAERFTGKLGAKYGLLAANGTVTLSMALRALGIHAGDEVITTAFTWIGTVA
                     GIVHVNAVPVLADISDDSWCIDPVKVEEAITDRTRAIMVVHLGNQVADMDALLDICRRH
                     NLLLIEDCAHAHFAEWRGRCVGTIGDAGSYSFETSKIMTSGEGGFLVTATEETFHRAMS
                     LAHVGRKEAPYDKFPGRVFGWNHRATEMQAAVLLGQLDQYDDLDRQRTAMAELLTKGLT
                     EIGGFIPLPEDPRVTRRQRYELLFRFDTEAWDGLHRDKVLEAILAEGVEFEGNTFYPPL
                     HRDELFHITADDWPAIRERYGEKISPDAFHLPVAERVAFDEAVWIHHSLLSVEPEDVQD
                     MLDAVVKVRENLGALKKSL"
     aSDomain        18610..19002
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis15_Aminotran_1_2.1"
                     /evalue="2.10E-08"
                     /label="sis15_Aminotran_1_2.1"
                     /locus_tag="sis15"
                     /protein_end="177"
                     /protein_start="46"
                     /score="25.5"
                     /tool="antismash"
                     /translation="PNTLHQQFAERFTGKLGAKYGLLAANGTVTLSMALRALGIHAGDE
                     VITTAFTWIGTVAGIVHVNAVPVLADISDDSWCIDPVKVEEAITDRTRAIMVVHLGNQV
                     ADMDALLDICRRHNLLLIEDCAHAHFA"
     gene            19736..20107
                     /gene="sis16"
     CDS             19736..20107
                     /codon_start=1
                     /gene="sis16"
                     /product="GTP cyclohydrolase I"
                     /protein_id="ACN38350.1"
                     /transl_table=11
                     /translation="MALTKLGRADTPPDRSLETFPITDSSQEITIDCREFTCRCPITGQ
                     PDWATIRIDYRPGDRGVETKSLKLYLETFRDEGIFHEHLATKMRDDLVAALEPVFLKVT
                     VDFNVRGGIALAASSTYQR"
     gene            complement(20200..21069)
                     /gene="sis17"
     CDS             complement(20200..21069)
                     /codon_start=1
                     /gene="sis17"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_functions="resistance (resist) APH3 (Score: 166.5;
                     E-value: 5e-51)"
                     /gene_kind="other"
                     /product="aminoglycoside phosphotransferase"
                     /protein_id="ACN38351.1"
                     /sec_met_domain="APH (E-value: 7.9e-31, bitscore: 99.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEPGRAMVAAAPIPVAGWGDRDDPRECLGERSSGATVYRVGEKAS
                     FYVKTTLPRHPDDPRFNPVKEAERLRWLADRGLPVPEVVALGANDDLQWVVTRTLPGRP
                     EERWRVIEVVADAARRLHDLPVAECPFERRLPDLIHEAKSSIELGAIDLADVDTAHEGW
                     TAQQLWDKLSRKVPPPEDDLVVCHGDLCLDNVLIDPDTLELAGIIDVDRLGVSDRWFDL
                     ALALYNIGEDDVWGYGAAHSEHFSGGTAAPPSTSTSWPTSSCSTSSSELIRGSVFRRRS
                     ARVWQISV"
     gene            complement(21084..22439)
                     /gene="sis18"
     CDS             complement(21084..22439)
                     /NRPS_PKS="Domain: Aminotran_3 (33-316). E-value: 3.4e-41.
                     Score: 133.2. Matches aSDomain:
                     nrpspksdomains_sis18_Aminotran_3.1"
                     /codon_start=1
                     /gene="sis18"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 264.7;
                     E-value: 2.2e-80)"
                     /gene_kind="biosynthetic-additional"
                     /product="aminotransferase"
                     /protein_id="ACN38352.1"
                     /sec_met_domain="Aminotran_3 (E-value: 1.2e-46, bitscore:
                     150.3, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSANLTNRGLIERARRATAAEKYDVQTRFSSMIQSGEGAWITDV
                     EGNRMVDLTASSGTLILGHRHPAVVEAIIRQIRDYGTAFASTLSVPRVELAERLCERYA
                     CAEKVVFHRTGTEGTAMAVRMARAATGRELILSCGYHGWHEWQLASETFGYQQTSGVVG
                     FGYNEKALEKMLEAFGDEVAGVLVSPELLYFDLDFYRRMAATCARYDVPFMLDEVYTGL
                     RAGPKGVHGLDVPADLVVMSKGLANGHALAAIMGRRDLIDAYDVAGIQGTYTREVPPMA
                     AALAVLDVLDTPGVYEHAERMGRLLADGMGEILTAEGIANRVGGPALMFDVVLPNDDLG
                     WEIYQAAHEYGVYFEDSGTQLVTTAFDEAAVDHVLTAFLKATRQVIADRPDIAPTSGGE
                     ITQERWLDFAEWAFGGLLRDDERTNAMIDGTIEKVVNRDRSIKPILIPDPAS"
     aSDomain        complement(21492..22340)
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis18_Aminotran_3.1"
                     /evalue="3.40E-41"
                     /label="sis18_Aminotran_3.1"
                     /locus_tag="sis18"
                     /protein_end="316"
                     /protein_start="33"
                     /score="133.2"
                     /tool="antismash"
                     /translation="IQSGEGAWITDVEGNRMVDLTASSGTLILGHRHPAVVEAIIRQIR
                     DYGTAFASTLSVPRVELAERLCERYACAEKVVFHRTGTEGTAMAVRMARAATGRELILS
                     CGYHGWHEWQLASETFGYQQTSGVVGFGYNEKALEKMLEAFGDEVAGVLVSPELLYFDL
                     DFYRRMAATCARYDVPFMLDEVYTGLRAGPKGVHGLDVPADLVVMSKGLANGHALAAIM
                     GRRDLIDAYDVAGIQGTYTREVPPMAAALAVLDVLDTPGVYEHAERMGRLLADGMGEIL
                     TA"
     gene            complement(23239..23751)
                     /gene="sis19"
     CDS             complement(23239..23751)
                     /codon_start=1
                     /gene="sis19"
                     /product="hypothetical protein"
                     /protein_id="ACN38353.1"
                     /transl_table=11
                     /translation="MTWTAPAVDRRPDPALGDERAVLAGWLDYHRDTLLFKCSGLTDAQ
                     LKTNSIPVTNLTLLGLVRHMTELERWLRTLFTGETAEDPYSTEERPDAAFDDVATADVV
                     ADFDLFRQEVELTRKAFSLRDLGDTYEDEGEVLNLRTTVVHILEEYARHNGHADLIRQT
                     IDGATGT"
     gene            complement(23798..24730)
                     /gene="sis20"
     CDS             complement(23798..24730)
                     /codon_start=1
                     /gene="sis20"
                     /gene_functions="other (smcogs) SMCOG1173:WD-40
                     repeat-containing protein (Score: 286.1; E-value: 8e-87)"
                     /gene_kind="other"
                     /product="putative WD-repeat-containing protein"
                     /protein_id="ACN38354.1"
                     /transl_table=11
                     /translation="MESAAAPTQPSLVLTGHREGVIGAVFHPDDHLVATSGEDGTIRLW
                     DATTGEQVGETLTGHTDTIWLVAFHPEGRLLASASEDRTARIWDVTTGRQVGEPLVGHT
                     AGVYGVAFHPDGTLLATGSADHTVRLWKVPGGEPVGEPLTASTDEIDGVAFHPDGHLVA
                     STGDAVRLYDTATGQPVGNPLVGHTKGAVSVAFSPDGRLLASGSDDLTVRIWDHAAGGP
                     AVGPLVGHTDAVDGVTFHPGGRLLVSAGEDCTVRVWDVASGKQVGELETGHTAPVWNMG
                     FDRTGSRIVTASQDGTARILPFPAYPAAG"
     gene            complement(24943..26349)
                     /gene="sis21"
     CDS             complement(24943..26349)
                     /codon_start=1
                     /gene="sis21"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 400.9; E-value:
                     9.3e-122)"
                     /gene_kind="transport"
                     /product="putative transmembrane efflux protein"
                     /protein_id="ACN38355.1"
                     /transl_table=11
                     /translation="MSDTAKQATGAARQQPDAAGPRKPGLVLALLAACALMIVLDSTVV
                     YVALPQIQQSLEMSGTGLVWVVNAYALAFGGLMLLGGRAGDIVGQRRVLLVGLVIFGVA
                     SLLCGLAPSPEVLIAARALQGVGAALVAPTSLSLIPINFTDDAARNKAIGVYTGIAAAG
                     GTLGLIIGGVLSDAASWRWVFFINVPVVALVLLLAPGAVKESQPQRGSFDVVGAVTSTG
                     AMVALVYALVRTSTESWGDPVVLVCLAVAAVLFTVLLLAERRARQPLLPLRLFTDRVRA
                     SGFVTLLFFPAAFAGLFFFLTQYFQGVWSYSALRTGFAFVPAAILVLVAAVLTGQLVPK
                     LGPSVVAGIGAVLTTVAMLWLTQLSADGGYATSLLGPLVLGGFGAGLIYASVTASIMSN
                     VAPEVTGAASSVLQAVQQIGPALGLAVLVTAAGTPADPVEGMRRAFWVAAVIAALPAVL
                     ALFNRRARTS"
     gene            complement(26534..27544)
                     /gene="sis22"
     CDS             complement(26534..27544)
                     /NRPS_PKS="Domain: PKS_ER (109-250). E-value: 4.1e-08.
                     Score: 24.5. Matches aSDomain:
                     nrpspksdomains_sis22_PKS_ER.1"
                     /codon_start=1
                     /gene="sis22"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     ADSI-DH"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     ADH_N"
                     /gene_functions="biosynthetic (rule-based-clusters) 2dos:
                     ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 306.5; E-value:
                     3.3e-93)"
                     /gene_kind="biosynthetic"
                     /product="2-deoxy-scyllo-inosamine dehydrogenase"
                     /protein_id="ACN38356.1"
                     /sec_met_domain="ADSI-DH (E-value: 2.3e-162, bitscore:
                     530.7, seeds: 6, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_N (E-value: 1.8e-26, bitscore: 83.5,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 1.8e-24, bitscore:
                     77.5, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRALQFHGGHKAQIIDTPRPEAPPGWGVVKVHYCCLCGSDLWLYR
                     GKWHGNRYPIVPGHEWAGVVDSAPKGYESWVGRPVTGDLIVGCQTCGPCRDGLPVMCEN
                     LIEIGFTVDGGCASYVAVPMTNLYPLPEGMDLAAASQTEPLAVALHAVDRINLRPAERV
                     AVLGAGGIGQLILQSAKATGATVTLATDLVAERRKIAEESGAAAAVHPSELPELTSYAD
                     KVDVVFEASGDPESVVRALDLVRPGGRVCLVGYQVGAEHALETARLPLSYASLVGVMGP
                     GGKYREAVDLLANGAIDTRPILTDIVTLDDYGPAIDRAINRTDGTVRVVFDLRGE"
     aSDomain        complement(26795..27217)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis22_PKS_ER.1"
                     /evalue="4.10E-08"
                     /label="sis22_PKS_ER.1"
                     /locus_tag="sis22"
                     /protein_end="250"
                     /protein_start="109"
                     /score="24.5"
                     /tool="antismash"
                     /translation="FTVDGGCASYVAVPMTNLYPLPEGMDLAAASQTEPLAVALHAVDR
                     INLRPAERVAVLGAGGIGQLILQSAKATGATVTLATDLVAERRKIAEESGAAAAVHPSE
                     LPELTSYADKVDVVFEASGDPESVVRALDLVRPGGRV"
     gene            28167..29543
                     /gene="sis23"
     CDS             28167..29543
                     /codon_start=1
                     /gene="sis23"
                     /gene_functions="transport (smcogs)
                     SMCOG1117:sodium/hydrogen exchanger (Score: 421; E-value:
                     7.2e-128)"
                     /gene_kind="transport"
                     /product="putative cation antiporter"
                     /protein_id="ACN38357.1"
                     /transl_table=11
                     /translation="MNSVHSDLKVAIVVADIAIVLIVGSLLIMLFRRLKQPPVIGEITA
                     GIVLGPSLLGLLPGDVTGFLFPAELRPHLSMISQVGLLLFMFLVGWEFNGQLLKRRSGS
                     VASVSLSAIALAFTLGIGAAALLYDRHDVVDGERVSFGYFAAFLGIAMSITAFPVLARL
                     LTETGLARTRVGALSLAAAALDDVMAWTLLAFIVVIFGAGGDGTGTLVAVLGLFLLYVA
                     LMVFGVRPLLRRLVARIIRGGTASPFLVPLIAAGAFLSAYATSWIGVHAVFGAFAFGLV
                     MPREPRALLAESLHIPLESATRLLLPIFFIVTGLNVDIGALGWTGLGELAIIMVAACVG
                     KLVAAGIAARLSGMNWQESYAVGLLMNTRGLTELVILNIGLSLGVLDGEMFTMMVLMAL
                     LTTAMAVPLLPKGLPRAPGGLFGVPSVTVPFGATTRRAPAQGDAADSAPTGHEVPSGKS
                     "
     gene            29692..30402
                     /gene="sis24"
     CDS             29692..30402
                     /codon_start=1
                     /gene="sis24"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_kind="biosynthetic-additional"
                     /product="transcription regulator related protein"
                     /protein_id="ACN38358.1"
                     /sec_met_domain="Asn_synthase (E-value: 6.4e-11, bitscore:
                     33.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWRVPTGKRKAVVLLSGGLDSATVLAMAVHEGYEAHALSFRYGQR
                     HTVELEAAARVAKALGATRHVVADIDLRVFGGSALTDDTLVVPHHASADEMGDEIPVTY
                     VPARNTIFLSFALAWAETLDASDIFIGVSALDYSGYPDCRPEYVAAYETMANLATKAGV
                     EGRQRLRIHTPLIQLTKAETIRRGLEMGVDYAWTHSCYDPVDGRACGTCDSCLLRGRGF
                     AELGLTDPALSTTG"
     gene            30399..31046
                     /gene="sis25"
     CDS             30399..31046
                     /codon_start=1
                     /gene="sis25"
                     /product="putative sisomicin production protein"
                     /protein_id="ACN38359.1"
                     /transl_table=11
                     /translation="MTGVYRIKEIFYTLQGEGTHAGRPAVFCRFTSCNLWTGREEDRHR
                     AICQFCDTDFVGTDGPGGGRFATAAELAAAVATAWRGQAHPRSRPYVVCTGGEPLLQLD
                     EAAVAALHEAGFEVAVETNGTRPAPPGLDWVCVSPKAGADLVLTRGDDLKLVYPQPGAE
                     PGRFEHLDFTHFMLQPMDGPDRVANTEAAVRYCLEHPQWRFSLQTHKYIGIA"
     gene            complement(31501..34962)
                     /gene="sis26"
     CDS             complement(31501..34962)
                     /codon_start=1
                     /gene="sis26"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 682.4; E-value:
                     4e-207)"
                     /gene_kind="transport"
                     /product="putative sisomicin exporter"
                     /protein_id="ACN38360.1"
                     /transl_table=11
                     /translation="MTVLHTTPRGDSYGASGETVVLRDTAHPLRSLRERQLALIVLCVG
                     ILISVIDGSAVYVALPSIQEGLGFSQANLAWVVNAYLIPFGGLLLLAGRLGDLIGTKRV
                     FLSGLSVFTVASMVCGLATDQAVLVGARFVQGVGGALTTAVVLSMVVNMFPKPREQARA
                     LGLYAFVAASGSAIGQLAGAALTASLSWHWIFFVNAPIGLVTILMGARLLDNVRDAKAG
                     KGIDWIGAVALVGSLMLTVYTIVQADSGAGRTALLGGVALLLMVGFVLWQRRTSNPLVP
                     ASVLRARNVAWSNVVLALMIAGPTAMFFLCALYLQNVLGFSVYELGFAFVPAALAIGIG
                     SLKVAPRLIRKNDAKVLLVPAMALMALGLLLLARIPADGSYWVDVLPAILLIGIGSGLA
                     TPPVLRIALADATLDDSGIRSGLLNTTQQIGSALGLAVLAPVAANVAESALAEGEAAAV
                     ALTEGFQMAFLVGFGTMVAAIVLAIFAVQSEVPKTAPQSLDETTTAPDLRKVDQTGAAD
                     PDFLAVGLGGANMMAMLWSIAMGRRVVGVELRGDPYLTLTQWKVSADIYHHLAVIDRLM
                     MERYGDEGIPRTFTGERFLLHELFYKLDPEDGAEARADEILFGWADSCLGGHVRIAEVV
                     DDRWVDGKPHRTVTEIRPPAPSMEHGPETVGRSMDDVLAESPAFQCNAEDLLIMLRRYL
                     EGIERMDLAAGREPRCRIFRYHRVAHPSRPAGWRRWLGRDDETVEDGFSRDADGRVRVR
                     IEAVREIDEKGTYRRIRVRGSELVDLGTPGLISIAEGVDSVDAKRLGFTQDLVRIDHGD
                     GRGPVVAQADYVVGLIAVYVGATSRQRIASDFDKQGNEYWIRQMTLGHDGFSESGWTIL
                     EVPDYRTFDPVQAGMVPPGTSQSSVEYFGAHRYLIRDYFLDQVSLLTEIPRRELARTLI
                     LATPKLVSNVEKIGRDALVAPNCVVAGDSFGTGSFLNSGGSITGMVGHAARVYRYWQAR
                     DEGVSHEEAVRQLADSIREDTLAWQRVSEADFAQPGHVRAGTDQQDGKRLDAVAREKVL
                     EATRRHRRAVARISNRLDDFGRLNVFPGRLQLVGLQPLQPTPPELRTEQTDGPVRLWPN
                     ITDGAMPGTSMADDSMMSMAGSDASMATDGQAVMVGSEERVGDMRM"
     gene            complement(34959..36911)
                     /gene="sis27"
     CDS             complement(34959..36911)
                     /codon_start=1
                     /gene="sis27"
                     /product="putative sisomicin exporter"
                     /protein_id="ACN38361.1"
                     /transl_table=11
                     /translation="MKNLRLASLVKRASRSSAPAVLDPTKQSRVPRGTKVEVDWTGIQN
                     PDFVALGLGATSMMSLLWSVAHGRQCVGVELRGDPSLGVHWNIREDFWHHLGLIDQLML
                     ERYGEEGIPRKGDGQLFKLRETFHSPVTEPGDVYADECIAGVEEAHVSGLIHYTEFIDD
                     RYVDGKPQRVLTVLNPSKPPAEHDPAKIGRDMVTVLDGPSTFQAGASEVLVMLRRYLEM
                     IQDMDIARGVTPRVRLFLSHRVAVGDEGDGDGFLKWMRQEDGFVSLPDGRKRLIIEEVQ
                     ELDYRGRYRRIRKPGSPLIDLGVPELFMIAQGFDSSDADRLGFRQEEVEVDHHDGRGPV
                     VAQADYLAGFLELHVGARLRRRIASEFDREGNEYWVRQIAVGHEDDPEVGWILVQVPDF
                     KTFDPILAGLVPPGTPKRSKEYLNAYQQLLREYYLEQVSLITELPVSDLERVQSPYGPK
                     LFSLVEKCGADALVAANGVVAGDSFGNGHFMTSGGAVTGMVGHASRVHQYWERRDEGVS
                     PQQAIRELADQIKVDTLGWLQVSSQEFSQAVPINFGEERIREIEKQTGRSSGERATTID
                     ATRRHRHSLVPLDPSDWRRLAVRSGRLHTSDLPPILETHPAERPMTCGAADAEMAAEDS
                     AQMREPVGIGAGSAS"
     misc_feature    complement(36894..36896)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(37480..38475)
                     /gene="sis28"
     CDS             complement(37480..38475)
                     /codon_start=1
                     /gene="sis28"
                     /product="predicted methyltransferase"
                     /protein_id="ACN38362.1"
                     /transl_table=11
                     /translation="MILRPGNGRGRRGGGGGRGAGDRVGRDDTGGRRVAEADGTRRSGA
                     ADPGTLYLVPTPIGNPGDITLRAIEVLGRVGVVASEDTRHTRRLLQSLEIDTRLLSYHD
                     HNEESRSQHLLGMLRDGTDVALVSDAGTPLVNDPGYRLVAAAVEADVPVRPLPGATASV
                     TALIGSGLPNHQFHYVGFLPRREAARRSALTALRSTVATLVFFEAPHRIVAMLEDVRAV
                     LGDRPAALARNLTKDDEEFLRGPLSDLIAGLDAEAVVRGQFTVVVAGAPGEPADEDEAL
                     AHRLTETLVRHGVEPRLVREVVREVTGLPRNWVYEQVRLAAQQGSAGTTE"
     gene            38665..39429
                     /gene="sis29"
     CDS             38665..39429
                     /codon_start=1
                     /gene="sis29"
                     /product="putative sisomicin production protein"
                     /protein_id="ACN38363.1"
                     /transl_table=11
                     /translation="MPDPDHPKITDIVVSPHFDDGALSVASVLRRGRPVLLVTICGGPP
                     TENGDDEWDRLCGFESGPAAAVGRAAEDRAAAALAGNRVTHLPVPDAPYRTDFPSAAVV
                     AALAPLFRPDVRVWAPLGIGSHPDHVGTRDAVLAAAAGTGCAVTFYADCPYAFGSGWDA
                     ADGDRPATDRWEPHLTALAHLVDATSPRVTRLDDSTMRLKIAMLRCHASQLAGLSVDHP
                     HFMAWEGPLRQEVFWPVSALIPGLEPTLGSSA"
     gene            39426..40388
                     /gene="sis30"
     CDS             39426..40388
                     /codon_start=1
                     /gene="sis30"
                     /product="putative sisomicin methyltransferase"
                     /protein_id="ACN38364.1"
                     /transl_table=11
                     /translation="MIVGGSTIQPERVDAAALRQLGDALRKVVGRAEPTPLADLLSGTP
                     VDPDALTGEIGVEGRRVLLDSGMAVDDGATFSSPLRGHQMHGVVVLSDPDVEEDVQHRW
                     YVDPLWEADLLIRLMLRRGGARALDMGCGSGVLSLVLADRYESVLGVDVNPRAVALSRL
                     NAALNGLTNVTFREGDMFEPAEGRFSRIVFNSPTNEEGSEFVDLLEAGEPILETFFRDV
                     PRKLESGGVVEVNLAMNDYPGTPFRDRLGDWLGLTENGLRVHIFTSQRRATGDGGEWKR
                     GWLVIAPGPVGLTETDWPYHGRYEEDPDSLLGATEQQLA"
     gene            complement(40495..40980)
                     /gene="sis31"
     CDS             complement(40495..40980)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (14-141). E-value:
                     4.3e-09. Score: 28.8. Matches aSDomain:
                     nrpspksdomains_sis31_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="sis31"
                     /product="activator of Hsp90 ATPase 1 family protein"
                     /protein_id="ACN38365.1"
                     /transl_table=11
                     /translation="MPVTDVRHDLDNLTLTITADFAAPVERVWQVYADPRQLEKVWGPP
                     TYPATVVDHDLTPGGRVTYYMTGPEGDKHAGYWLVKSVEEPRGFSFDDGFADLDFNPNP
                     DLPVSGNVYTFTEHDGGTRATYVSTYASAEALQQVLDMGVVEGASGAINQIDELLAS"
     aSDomain        complement(40558..40938)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis31_Polyketide_cyc2.1"
                     /domain_subtype="Polyketide_cyc2"
                     /evalue="4.30E-09"
                     /label="sis31_Polyketide_cyc2.1"
                     /locus_tag="sis31"
                     /protein_end="141"
                     /protein_start="14"
                     /score="28.8"
                     /tool="antismash"
                     /translation="LTITADFAAPVERVWQVYADPRQLEKVWGPPTYPATVVDHDLTPG
                     GRVTYYMTGPEGDKHAGYWLVKSVEEPRGFSFDDGFADLDFNPNPDLPVSGNVYTFTEH
                     DGGTRATYVSTYASAEALQQVLD"
     gene            complement(40984..41328)
                     /gene="sis32"
     CDS             complement(40984..41328)
                     /codon_start=1
                     /gene="sis32"
                     /gene_functions="regulatory (smcogs) SMCOG1058:ArsR family
                     transcriptional regulator (Score: 65.9; E-value: 4e-20)"
                     /gene_kind="regulatory"
                     /product="ArsR family transcriptional regulator"
                     /protein_id="ACN38366.1"
                     /transl_table=11
                     /translation="MVTDESEDRADAMFQALADRTRRDILRRVLAGEHSVTALAAKYDM
                     SFAAVQKHVAVLEKAGLLTKRRSGREQLASGDVAAVRSVASMLTELEQVWRGRIARIDA
                     LIAADFDQED"
     gene            41391..42056
                     /gene="sis33"
     CDS             41391..42056
                     /codon_start=1
                     /gene="sis33"
                     /product="putative serine repeat antigen"
                     /protein_id="ACN38367.1"
                     /transl_table=11
                     /translation="MAAVRRTGVSSWRTIGAAGRRAPATRAHVRERAPLAEGAGPASTG
                     VARRHTGPVSVGQSSSRSSSSSSSRSSSSSFRSSSSSTGSCSALTTLPLVRSTSISCSV
                     PPVHDLDAPHLTAVLLLRLDLHDPAALRRGPTRSPRRASRPPRSRSPGWWCHRTVWWAH
                     RSPPGRWGWRGCRSGWRGQSGPWSPRSGWYDRSARRRRQRCRSPLRPPPAPPHPPGCP"
     gene            complement(42176..43483)
                     /gene="sis34"
     CDS             complement(42176..43483)
                     /codon_start=1
                     /gene="sis34"
                     /gene_functions="regulatory (smcogs) SMCOG1003:sensor
                     histidine kinase (Score: 102.1; E-value: 6.8e-31)"
                     /gene_kind="regulatory"
                     /product="putative two-component system histidine kinase"
                     /protein_id="ACN38368.1"
                     /transl_table=11
                     /translation="MRARLALLAAAVSVLTLVAFLVPLALLVRTVAEDRATVRATADAQ
                     SLVPVVGTADPATIRLTVERLAVESGRPVSVFLPDGTVLGTPAPRTPAVALAARGQSLT
                     AESAEGREVVIAVQGRPDGTGVIRTVVPGAELTAGVGRAWLVLALLGGLLVVISLVVAD
                     RLAHTLVRPISELSAVSHRLANADLDARVTLAGPTELREVAGALNHLAGRIQELLGQER
                     EQVADLSHRLRTPLTALRLEAESLGDPQDAARITSAVDGLERAVTGLIRQARRQRPAVG
                     PVGCDAAAVVADRVQFWSVLAEDTGRTVHRELASGPLPVAVPAEDLAAAVDALLGNVFA
                     HTPDGTPFTVRLAPTGAKRSGASGEMLLTVADEGPGMPPDTVRRGASTAGSTGLGLDIA
                     RRAAEVGGGRLEVRSGRTGGAEVLLRLAPPAAPSGT"
     gene            complement(43480..44175)
                     /gene="sis35"
     CDS             complement(43480..44175)
                     /codon_start=1
                     /gene="sis35"
                     /gene_functions="regulatory (smcogs) SMCOG1008:response
                     regulator (Score: 201.7; E-value: 1.9e-61)"
                     /gene_kind="regulatory"
                     /product="putative two-component system response regulator"
                     /protein_id="ACN38369.1"
                     /transl_table=11
                     /translation="MPRLLLIEDDLTIRTPLVRALRDRGHAVAAASTAMDGLRDALENR
                     PDLVVLDLGLPDLDGRELLRMLRAVSPVPVIVATARDDETEIVRVLDAGADDYVVKPFT
                     AAQLDARVRAVLRRGGSAAGADDPALVVGGLRVDPRARQVTLDGEPVELTPREFDLLHH
                     LAARPGEVVTKRELMTEVWQIPYGGADKTVDVHLSWLRRKLGENAQQPRYLHTVRGVGV
                     RLAPPEEAG"
     gene            44279..44722
                     /gene="sis36"
     CDS             44279..44722
                     /codon_start=1
                     /gene="sis36"
                     /product="putative secreted serine protease"
                     /protein_id="ACN38370.1"
                     /transl_table=11
                     /translation="MRRPFLAVAGWLVTAVLLTLVGVAAIRLVGESITGTPGGVRSQEE
                     VERALAAPEPSAASATPGAPPPTASARSGVPRVFATTGGSAVAECGPDGVRLVSWAPAQ
                     DYRVGAADRGPDDDVEVSFVGPSGEHELKLRCVGGEPVAEPDD"
     gene            complement(44976..45713)
                     /gene="sis37"
     CDS             complement(44976..45713)
                     /NRPS_PKS="Domain: PKS_KR (6-166). E-value: 2.3e-18. Score:
                     58.6. Matches aSDomain: nrpspksdomains_sis37_PKS_KR.1"
                     /codon_start=1
                     /gene="sis37"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     220.2; E-value: 5e-67)"
                     /gene_kind="biosynthetic-additional"
                     /product="short-chain dehydrogenase/reductase"
                     /protein_id="ACN38371.1"
                     /transl_table=11
                     /translation="MTVPQRVAIVTGGSQGIGRQIVKRLAADGYAVVLNYATSKVEAEQ
                     TVAEIAAAGGDAVAVQADVADEFAVARLFDTAEQTYGGIDVVVNSAGIVVHAPIVELDL
                     ADLDRVHRTNVRGTFVVDQQAARRVRPGGAIINISSTTPKLSLPTYSAYAASKAAVDAI
                     TLILARELGERDITVNAVAPGATATALFLDGKDEQAVARMAAMSPMNRLGEPADTADVV
                     AFLASPAGRWINGQVLYVNGGAA"
     aSDomain        complement(45216..45695)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_sis37_PKS_KR.1"
                     /evalue="2.30E-18"
                     /label="sis37_PKS_KR.1"
                     /locus_tag="sis37"
                     /protein_end="166"
                     /protein_start="6"
                     /score="58.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VAIVTGGSQGIGRQIVKRLAADGYAVVLNYATSKVEAEQTVAEIA
                     AAGGDAVAVQADVADEFAVARLFDTAEQTYGGIDVVVNSAGIVVHAPIVELDLADLDRV
                     HRTNVRGTFVVDQQAARRVRPGGAIINISSTTPKLSLPTYSAYAASKAAVDAITLI"
     CDS_motif       complement(45630..45689)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_sis37_0001"
                     /evalue="2.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="sis37"
                     /protein_end="28"
                     /protein_start="8"
                     /score="13.8"
                     /tool="antismash"
                     /translation="IVTGGSQGIGRQIVKRLAAD"
ORIGIN
        1 gaagagatgc gtactagaag attccggccg ttgccaggga aaaactcacc agtgtctccg
       61 ccatcgagca ccccgacccg acattcgcag gtcgcgggct ccttaccacc cttcggtgga
      121 aggtgctcct tagaaaggag gtgatccagc cgcaccttcc ggtacggcta ccttgttacg
      181 acttcgtccc aatcgccagc cccaccttcg acggctccct ccacaagggt tgggccaccg
      241 gcttcgggtg ttgccgactt tcgtgacgtg acgggcggtg tgtacaaggc ccgggaacgt
      301 attcaccgca gcgttgctga tctgcgatta ctagcgactc cgacttcacg gggtcgagtt
      361 gcagaccccg atccgaactg agaccggctt tttgggattc gctccacctc acggtatcgc
      421 agcccattgt accggccatt gtagcatgcg tgaagccctg gacataaggg gcatgatgac
      481 ttgacgtcat ccccaccttc ctccgagttg accccggcag tcctcgatga gtccccgcca
      541 taacgcgctg gcaacatcga acgagggttg cgctcgttgc gggacttaac ccaacatctc
      601 acgacacgag ctgacgacag ccatgcacca cctgtgaccg cccccgaaag acccgacatc
      661 tctgccggtt ttgcggccat gccaaaccca ggtaaggttc ttcgcgttgc atcgaattaa
      721 tccgcatgct ccgccgcttg tgcgggcccc cgtcaattcc tttgagtttt agccttgcgg
      781 ccgtactccc caggcggggc gcttaatgcg ttagctgcgg cacagagaac cggagaggcc
      841 ccccacacct agcgcccaac gtttacagcg tggactacca gggtatctaa tcctgttcgc
      901 tccccacgct ttcgctcctc agcgtcagta tcggcccaga gacccgcctt cgccaccggt
      961 gttcctcctg atatctgcgc atttcaccgc tacaccagga attccagtct cccctaccga
     1021 actctagcct gcccgtatcg actgcaggcc cgcagttgag ctgcgggttt tcacagtcga
     1081 cgcgacaagc cgcctacgag ctctttacgc ccaataaatc cggacaacgc tcgcgcccta
     1141 cgtcttaccg cggctgctgg cacgtagctg gccggcgctt cttctgcagg taccgtcact
     1201 tacgcttcgt ccctgctgaa agaggtttac aacccgaagg ccgtcatccc tcacgcggcg
     1261 tcgctgcatc aggcttccgc ccattgtgca atattcccca ctgctgcctc ccgtaggagt
     1321 ctgggccgtg tctcagtccc agtgtggccg gtcgccctct caggccggct acccgtcgtc
     1381 gccttggtag gccatcaccc caccaacaag ctgataggcc gcgagcccat cccaggccga
     1441 aaaactttcc accagcgatc atgcgatcga cggtcctatt cggtattagc cccggtttcc
     1501 cggggttatc ccaaagccta gggcaggttg ctcacgtgtt actcacccgt tcgccgctcg
     1561 agtaccccga agggcctttc cgctcgactt gcatgtgtta agcacgccgc cagcgttcgt
     1621 cctgagccag gatcaaactc tccaacgaaa acttgttgaa caatcgtccc ggcaacaaaa
     1681 gtgttgccaa aggaatccca accaaccaga cacaccgaag catgcccagc cagtccgggg
     1741 tataaatcat aattggcact ggcttatcaa gcaccctgtt gagttctcaa agaacaacca
     1801 cacaccatcc agaaccctca ccaggcacca tccggggcaa tccgttccca ctcccgccgc
     1861 tctcgcgccg ggcacttcta ctacgttacc tcaccgtttc cgccgtgtca aaccgtgtgt
     1921 cccggtctgt cgtgcttggt acggtttgcc tccgctgacc gcaggcagcg gcgaaccgct
     1981 gcgctttgct catcggattc ggcaggccgg ccgctgcggt ctcccgctcg ctcgcccggt
     2041 gccctgccgg tcgtgaacct tacccggccg gttccgcccc gccaaatcga cccctcggtc
     2101 gatccggtgg agcaccaccc ggatcccgat gccggagggg tgaatccctc ccgcctcgta
     2161 ccgcccggct tcggactccc aggtgctttg ccctgtttcg tccgttccgc gctggcagag
     2221 agaaagttac gcgtccgagg gtttgagcgt caaatcgggg ggtggcggcc cgcgtcacat
     2281 cgtcgacgtc tggctatacc gcctggtcag aagggttgtc accacgtttc cgggcacgcc
     2341 gctgggcgag cagaccccgg acacccagcg cgccgaccgt cgtaccgatg gtcagggacg
     2401 cggcgatgag tagcgcatgg atccagagga acccggtgcc gtcgccctcg ccgaccgtcc
     2461 cggacgacca cgcccgggaa tcgttccaga tggccaccgc gaacctcggc cagatcgccc
     2521 aggtccagaa cccgacgccg acgaggaata acgaccatcc acgggacaac accatggccg
     2581 acgagtatgc cagcgccgca gtcacaccgg ccctgatcac gcctgccccg cctccccgcg
     2641 caccgggtca ccgtggatcc gtggtccggg cgagcagctt cccgccggtg ggcgtcgacg
     2701 cgagcgtcga cctgccgggc gatgccgtgc cgcacacgcc ggcgaccagg tccggggatg
     2761 ggcgtgaacg cctcctggac gtcctccgtg cccgcgggct gcggttccgc gacggcgcgc
     2821 gctggcagtc ggctctctga gccgaccctg ctgaacaccg accggggcgc tccgccccgc
     2881 gtcgacgcgc gcacgcgaac cctccatccg tacgacacga gaggcccacc accatgtccg
     2941 ctgcacagat gctcaccggt gaccgcccga cggggcgact gcacctcggc cactacgtgg
     3001 gcagcatcgc caaccgggtc cggttgcacc agcgctacga gagctttttc atcatcgccg
     3061 acctgcacat gctcaccacc aggaacaccc gcgaggacat ctcccgggtg gccggcaacg
     3121 cccgggagat ggtggagcgg ctcgcggtgg cgctcaaccg gttcctcgac ccgatgcggg
     3181 aacgccgggc ccgcttcgcg gccgagcgcg ggctggtcga ccagctgatc gccgacggca
     3241 ccgaacgcac tcgccaggag gtccggcgga ccctcgccga ggtacgccgg gcgatggggc
     3301 tgaccgccgc gtaccagcag atccgccgac gggccgagcg gtcccggcgg aaggccgacg
     3361 caccggccac cgccggcacg ggcggcgcgt gaggcccggc ccgtcggggc acgtatcctg
     3421 gagaatccgt ccgcccgctg ccgaggagct gcgtacctga tgacctccgc ggattctacc
     3481 cgccggcggc ccctccctgg acacgcgcac ggctcggtcg tcttgcccac cttcctgccg
     3541 acgggacgcg ggcctcggtc cgggcggtcg acacccagga cctgacgacg gtggggatcc
     3601 aggcggtgat ggtcaacgcg atgcacctgg cgcagcgtcc cgggctccag accatcggcg
     3661 ggccggcggg ctgcaccgct tcatggcctg ggacggggtg atcgtctcgg actccggcgg
     3721 gttccaggtc ctctccctga tccgtaagca gggcaagact ggtgcgatcc ggtccaacgg
     3781 ggtgaccttc caggagtcac cgaccgccaa gaagatcgtg ctgaccccgg agaaggtcat
     3841 cgagtggcag ttcgggctcc gctcggacgt ggtggtcgcc ctcgacgact gcaccggccc
     3901 ggaggactcc cccgccgagc agctcgcctc caccgagcgc acgatccgct ggttccggca
     3961 ggcccggaag gcgtacgacc tccagtgccg gcagcggcgg tcgggcgagc cgccgctgct
     4021 ggtcggggtg gtgcagggcg gcaccgaccc ggagctgcgg cagcgttgtg tggacgccct
     4081 ggtcgaatcc ggggcgcagg ggttcggctt cgggagttgg ccactgagcg ccgagggtga
     4141 gctggagcgg gagatgttcg ccctgctctc ccggatcacc ccgccggacg cgccgctgtt
     4201 cgccctcggg gtgggccggc ccgagcacct ggtctccctc tgcgagctgg acatgcgctg
     4261 ggtcttcgac tgcaccatcc cgacccggga cgcgcggcac ggccggctct actcgttcgt
     4321 gccggagatc gccgaccggc tgctgacccc ggaccggagc ttctaccaga acgtctacat
     4381 cctggacgag gagaactccc gcaaggacga gccgatctgc gccacctgcg actgtccgac
     4441 ctgccggcgg tacagccgca gttacctgca ccacctcttc cgggtcaagg acggcctggc
     4501 ggaccggctc gccaccctac acaacctgcg cttctacacc cgcctgctgg agatgatccg
     4561 ggcgggacgg atggcccggc ccggtctcgg cgagccggcc cgggtggggt gagcgagcgg
     4621 tgacggtgtc gccggctgtc gagaaggtga tcgtccggct cacctcggcg gccaagtacc
     4681 gggacgtcca cccggagacc atcgccgacc tggtccggcg ggaggggcgg gccaccggcg
     4741 acgccgccga gctggaacgg ctggtccggg cccggctgca caaggtcgcc gccctgcacc
     4801 tgctcaccgc ccggccggcg gcgttgcgcc gggcgctgga ccgggccgac ctcgacgacc
     4861 cgcaggcccg gcgggagtgg tgccggcagg tgctggccgg gcacttctgc accgccgagc
     4921 gcctgcccga cctggacacc ttctacccga ccctgttcgg gctggtgccg ccaccggaga
     4981 cggtggccga catcgcgtgc gcgctgaacc cgttcaccct gccctggatg cgggaggtga
     5041 gcgacgcccg ctacgtgggc tacgacttca acgcgacgtt cgtggcgctg ggcaacgcgt
     5101 ttttggcccg gacctacccg gagagcgaga tccggcacga ggaggtgctc accgacggtc
     5161 accaggtgag cgcggacctg gcgctgctgc tcaagacgta ccactgcatg gagggacgcc
     5221 ggcccggcgc ggggctggcg ctggtcgacc ggctggcgtg ctggcacgtg gtggtgtcgt
     5281 tccccacccg ggccatgaac ggccgggcgg cggtcttcgt gccgcgccac gtcgaggaac
     5341 tggccgagtt ggcccgcgac cggggttggc gctggtcgcg ggccactctg ccgtcggagg
     5401 acctggtggc gatcgacaag gggtgaccgc cggggtgcct cagtcctccc agaggcgctc
     5461 gacgatcgcg gtggtctcct cccgggtacg cggccggtcg gccagaccgt ccatcgcccc
     5521 ccaggcgctg gcgtaccagg actcctcggt gagttcgcgg ccggtgaaga ggccggcgag
     5581 cgtggcggcc acctggtcga tccgtccgca cgcgtcctcg accacctcgt cggtgaacgc
     5641 cgtcgagggg gtctggttgt cgccctcgaa gaagagcagc ccctcgtccg ccgcggcggc
     5701 gtggaaggcg tcctgcacct cgtcgtcggc gcagacgaac tggaagaggt tgccgttgcc
     5761 ggcgaggtcg atcgggacgc cggcgccgac gaacgccgcg cgggtgtggg cgatgaaccg
     5821 gtcacccgcg gcccggatgg cctgctgcgg ctgtccggtc gccatccgcc gcagggtggt
     5881 ggtcgcggcg gccagcgcgg tcggctcgaa gtacgaggtg aacgaaacgt cctccagcgc
     5941 ggcgagcagg tgggcgtccc cgcccaccgc cgcgaccggg gagccgttgg ccaggcactt
     6001 cgccacgatc caaacggccg ggtcgagcag gtgggtggag agcccggccc ggtagcggag
     6061 gccgaccttg acctcgtcgg cgatgaccgg gacgtccgcc tccttcgtca gccgggtgaa
     6121 ctcggtgtac cagcgctcgc cgaggtgcat gtggtccggg gagacgacca ccgcggccac
     6181 ctgctccggg cggctgagcc actcggcgag cacgtcgagg tcgaagagga actcgacgac
     6241 gccgtgctgg ttgggggcga agggctcgtc gcagtgccac atcgggtcgt acccgtggta
     6301 gccggagctg aggatgattg accgttcccg ggcgtcccgg acggcgcagg tcaccgagcg
     6361 cagggcggcg gtgccggtgc ggtagagacc gaccacgtcg ccgccgcaca cctcctgcaa
     6421 ctggccgagc agggagtcga gcaccgggct ccaggcggtg cccaccccgg agcggccacg
     6481 ggcggcgcgg gcgatcgcct cggcgacctc ctcgtcaccg tggccgagga tgaccgagcc
     6541 acgggcgttg tcgaagtcga tccaccgccg gccgtccggg tcggtcaggt acgcgcccga
     6601 gccctcgatg aagacccggg gacgtccgtc ggcgtcccgg gggcaggtgg gttcctgggc
     6661 cagcagcttg ccggcgccga tgtcgatggt catgcactcc gctcgattca ctctgttccg
     6721 acaggtgggg aggagaagcc ggattcgata ccgaactccc ggcgcagcag ctggtgggcc
     6781 atccgcaggg cgagggactg gatggtgagg gtggggttga cgccgcccgg gtagggcatg
     6841 acgccgccgt cgaccaccat caggttggtc aggccgtgca cccgcccgtc cgggtcggtg
     6901 accgaggtcc gggggttggt gccggcgcgg caggtgccgt gcaggtgggt gctgcccatc
     6961 cagaagtacg acgattcgcg ccaggtcagc tcacagccgg cggcccgcag gatctcctcg
     7021 gcccgccgct ggaggtactc caggcgggcc cggtcccggg ggtggggcga gtagtccatg
     7081 accacgtccg gcaggccgaa ccggtcgacg ccccggccga gggtcacccg gttgtcggcc
     7141 cggggctggt cgggcaccag gcactcgagc cggatgatct gctcgtcggg gcgcagccgg
     7201 agggactcct ccggttggga ctcgatgatc agcccaccga ggccgccggg cgcgtcgtcg
     7261 gcggtgtagt agtcggtgat cgcggcggtg gagaaggggc cgggaccggc gacccggtcc
     7321 tcgcgcgagg tcgtcggcac gtcggtccgc cggtagccct ggacgtaccc gctcatcttg
     7381 aagcacaggc cccggccgac catgtcgtgg tcgttgccca ggccctgtgg gctcaggtcg
     7441 tcggtggagc gcagcagcag ggcggcactc tggatggcgt tgccggcgac gaccacgtgg
     7501 cgggcccgga tgacgtgccg gttgccgttg tccacccgga cgcactcgac cccgtcgacg
     7561 ctgatggcgt cccggcggag cagccgtacg gccttcaggc cggcgaagag gcgcagtccg
     7621 gccttgcgcg ccgggtcgag gaagacggtg accgcgtcgc ccttggctcc ccggtcgcac
     7681 cggttggaga tgcacgggcg cttcccggcg cacgccagcc gcccctggta gggctcggag
     7741 gcgatggcca gcggtgtcgg gaagggattc aggccgaggg accgggccgc ggccgcgatc
     7801 accgcgccct ccacagtggt ctcgaccggt ggcatcgggt acgcggggtc gctcggcagg
     7861 ctcgggtcgt gcccgccacc ggcgatgccg agcgccgact ccaccagcgc gtagtagggg
     7921 tcgatctcct ccaccgtcca cggccagcgc agcggcaggt cggagcggcc cagccgggcc
     7981 tccgcgtcga agtcgaccgg gcggtagcgg aaggccgcgc cgccgaagaa gaccgttcct
     8041 ccaccgacgt tgcaggtgga ccaggggttg ccgctcttct cccagacgcc gctgtcctga
     8101 cggatccagg cggtctcggc gatcgtctcg acgtcgtcgt agctcaccca gggatccacg
     8161 aagggtccct gttcgacgat cacgacgtcg agaccggcac gttgcagggc ccacgcggtg
     8221 atcgcaccgg aggcgccact gccgatcaca cagacgtcgg cgacacgggc ggtgtcgtcg
     8281 gcggtcggct ccgggccgta ccgcagccgg gccgtgacgt cctcgtgacc ggtactgagg
     8341 tcggcggaaa cgctgatgag aacctcccgg gttgggtctg cgtgccggcc ggccttgggg
     8401 tcccgacggg accgaccggt cactgaggtt ggccgtgcgg gggtgcgccg acggtcacgg
     8461 gctcggcccg cagcgcgtcg gggggttgcc ggacggtgag cacctggccg gtggtcccgt
     8521 gccggcgggc ggccgtgacg gcccaggcca ccagccgggc ggcggccgag gtgtcgtcgg
     8581 gtgcctccgg gccgcccatg tcggtgggga tccagcccgg atcgaccgcg ttgacgacga
     8641 cgtcctgttc gcgcagggcg acggccaggt tgacggtcat gatgttcagc gcggccttgg
     8701 ccatccggta gccggtggcc tccccgtcgg cggtggccgg atcggcgtcg tccgcggtca
     8761 cgttgaccac ggcggccccg cccgccgccc gcagcagggg gagcacggcc cgggtcacca
     8821 gcagggggcc gacggcgttg acggtgagca gctcgtggac ggcctcggcg gtcacgctct
     8881 ccaggtcggc gtcgcgttcg tcgaggaaga ccccggcgtt gttgaccaga ccggcgaggc
     8941 gcccgccggt gtggtcggcg accaggtcgg ccgcggccgc gatgctcgcc ggagaggtca
     9001 cgtccagggg tacgtggacg gcccggccgc cccggcgacg cagcgccgtg gcggccgccg
     9061 caccccgccg gtcgtcgcgg cacccgagca ggacggacca gccggcgtcg gccaggaggg
     9121 tcgcggtggc caggccgagg ccccggtttc caccggtcac caggacgtga cctccggccg
     9181 gcgtggtatc cgggctcgcc ggggcggtgt ccatactccg ctgcccggtc acttcccgct
     9241 cgccgccccg gccccggtga gggcggcgcg gtagcagtcc agcatccggt cccgggtggc
     9301 ggcgacgtcg aaggtgctgg cggtggtggt ctgcgcggcg tggatccggg cgaccaccgc
     9361 atcccggtcg gccagcacac gccggacgac ctcggcgagt ccgcgcacgt cgccgggctc
     9421 ggtgagcagg tcggggcagg ccgagccgat ggtgctgcgc agtcctccga ccgcgtaggc
     9481 ggcaaccggg gtgcccgcca tgatcgcttc gatcgcgctg ccgccgagtt cctcgtggat
     9541 cgagggcatg accagggtgt ccaccagggc gagcgcggcc ggcacctggt cgtgcggcag
     9601 gaagccggtg accacgaact ggtgggcgcg gccaatctcg gcgatctcct tctccatccg
     9661 ctcccgctgc gggccgtccc cgacgacgag gaaggtcggg gagaggtcgt ccaggagttc
     9721 ggccagtcgg agcaggtccg gccagccttt ctcgtgggcg acccggccga tgtacccgat
     9781 cagggggcgg cggccggtca ggccgtaccg ctgggcgaac gccgtcgtcc cggcctccgt
     9841 cgccggggtg atctcgaccg cgtccgggtt gaccacgatg gcggaccggt ccaggccggc
     9901 cgcggcgctc accacgtcgg cggtccgggc ggtcagggtg gtgacccggg tcgcggagcg
     9961 cagcgcctgc cgttccgcct gcgtgacgag gcggtgcgcc atggcgtcca ccgtcgacat
    10021 gggctggtag acggagagcc gggaacagtg cagggtgagc acgtacggca cgcccaggat
    10081 ccgggcggcg atccgacccg cgaccagcgg ccagatctga ccgtcggcgt gcacgtggac
    10141 gaggtcgggc cgccagtcgc cgcgacgcag ccggaggcac tcccggatgg ttccgatcag
    10201 ccacgcctga cccaacccga ccaggccggt gatctcggag cggatctggg gcagggacat
    10261 ccgggcgatg cggacggtca acccgggctc gatctgcttc gtcggcggca ggccgggaaa
    10321 gcccagagtc agcacgagct ggtcgacgcc cgccctggcc aggctgcggg acaacgccag
    10381 gatctgcacc tgcataccgc ccaccggatc gaactcggcc ggccagtggt cgacgtagtc
    10441 gtggtggaag aagggagtca accgaagtac acgcacgacg ccatccgatt ctctcgaaag
    10501 agtggcgaaa agctatttct gaataacgta aatcagctcg ttgccgatct ccagtcgctg
    10561 aatgcggcac gatcgttcgc tggcctggga ctcaaaactc tgtgaatagt tctgaaacat
    10621 tcccttcgat cgctgaccga gagacttggt cgggaaggtt accacgataa tcggcgagtt
    10681 gacaatgtca atcacttccc agccggagcc tcgttgctga gtctccagac aggggagcgt
    10741 cttcagcaat agcgtgacgt cggccggctc gtcaaggcgg gcctccagga ggtcgaccac
    10801 gctcgtacga tgcgccaccc ccagcctcgt cagggccgcg cccacgaagt ccatcaggcg
    10861 ggcgtcgatg tcggaggcga cgtagacggt ctcgtcggac aggcccatcc agggtgcggc
    10921 cagcgggttg aggccacacg ccaggtcacg cagcgtgttt ggccggggaa cgtgacggaa
    10981 gatctcccgg tagaactcgt cgaggtgcgg cagccgctcc cgggtggaca tgtgcaccga
    11041 catcgcacga gacagggccg aacggaccgc ttcacccccg gcctcgactg cggtgtcgag
    11101 ctgccgcagc aacgctgtgt agttaggcgc actgggcggc aggaaggcgc cgtagatctc
    11161 gtgcagcccg cgcttcgtgc gcttcaccgc gtccggcacg tccccccgcg aggcgaccag
    11221 ggcggcccgg gccaggcgac gcacggtggc cggggccacc gtctggtagc gccggctctt
    11281 ggtgatggcc tgctgaatct ggtcgatacg gtcgtcgccc gtagatgtcg tcatcgagtc
    11341 ctccgaagga tcctgaaccg gtagcgaagc ggaaatattc cccgccgata caccggcccg
    11401 cataccaaga gttattggtc tgtctactgt gggttgtcgc cgatcaacta cggggccaac
    11461 gtgggagcac ccgcgctcga cacccgaccg agtccatatc ggaggcactg tcccgcaagc
    11521 ccggcttggc cggtttttgc acgtcgacac tggtgattgc gtctggcaca cttggccgag
    11581 cccgcgatct actggttgcc gcagtctggg cctgggaagg acgtgaaagt gacccttctt
    11641 gccgtcaatg gtggttcccc gatacgttcg cagcagtggc cgttgtggcc cgctcctgcg
    11701 cccggcgccc tcgacgcact gaatgaggtt ctccattccg gtcgctgggc catcagcggg
    11761 ccataccagg ggaagcagag cttcgagcga cgattcgcgg cggcattcgc cgagttccat
    11821 gggatcgggc actgcgtgcc gacctccagc gggactgcca gcctcatggt ggcgctcgag
    11881 gcgtgcgggg tcggtgccgg tgacgaggtt atcatccccg gtctgacctg ggtcgccaac
    11941 gcatccaccg tcgccggggt caacgcggtt cccgtcccgg tcgacgtgga cccgcggacc
    12001 ctctgcctcg acccggcggc cgtcgagcgg gcgatcaccc cgcggaccgc agccatcgtc
    12061 gtggtccacc tctactcggc cgtggcggac ctggacgcgt tgaccgcgat cgccgagcgg
    12121 cacgacatcc cgctgatcga ggactgcgcg caggcgcacg gcgcacgcta ccgcgaccgc
    12181 cgggtgggca ccttcggcgc cttcggcacc ttcagcatgc agcacagcaa ggtgctcacc
    12241 agcggcgagg gcggcgccgt catcaccggg gaccccgcac tctcccgccg ggccgagcac
    12301 ctgcgggcgg acggccgcac ctacacgccg gacgagcccg ccgtcgggga gatggagctg
    12361 gcccagaccg cggagctgat gggcagcaac cggtgcctgt cggagttcca ggcggcgctc
    12421 ctgctcgccc agctcgaact gctcgacgag cagaacgatc ggcggcgggc caacgcggcc
    12481 ctgctcgacg agggtctcgg cgcgctcggc atccagcccc aggtctcctc gcccggcacc
    12541 accgagcgca cctactacga gtgggccggt cggatctccg acgacgggat cgggcagatc
    12601 ggcgtcgagc ggatcgccgc gacggtcgcc gccgagctct ccggcgcggc catctacgcc
    12661 agctaccccc cgatgaacca caaccggctc taccggcccg ctacccggtc gcggttcaac
    12721 ggcgtcccgg gactcgacct gaccggctac ccgctgccgg tcgccgagga cgccggtcaa
    12781 cgggtcgtca cgatccacca ttcggcgctg ctgggcgacg agtcggacat gaaggacatc
    12841 gtccgcgcct tcgagaaggt gttcacgaat caccgagaac tgcgcggctg accaccaggg
    12901 ccggacgggg gaggctcccc catcgacccc ggccccggca gttgcgatcg ggagccccga
    12961 ccccggggct cccgttggga agggccccat ccaagggttg taaggacccg tgacgaaggg
    13021 taagcgtatg gaggtcgaga tacgcctggg cgcggttcgg tatccgttcc ggctcggcac
    13081 cgattgtctc ggtgccatcg tggaggacct ggtcgcgatg tcggccagtc gactcctgat
    13141 cgtctgcgac agcaacaccg gtccactgtt cggcgcggaa ctggtcgaac gtctctcccc
    13201 acgggttccg gcgaacctgc tcatccaccg ggccggtgag ccgtacaagg atctccaggc
    13261 cgtcagcacg ctggccgagt cggcgctcca gctcggcgcg gaccgcgcct cggtggtggt
    13321 cgccgtcggt ggcggcgtga tcggcaacat cgcggggttg atggccgcac tgctcttccg
    13381 cgggatccgt ctcgtccacg tcccgacgtc gctcatcgcg atgtccgact cggtcctctc
    13441 cctcaagcag gcggtcaacg ccagcgtggg caagaacctg gtcggcacgt tctacgcgcc
    13501 ggagtccgtc ctggccgaca ccgccatgct gcggagcctg ccgttccggg agacggtctc
    13561 cggtctctgc gaggtcgtca agaactcgct ggccatccgg cccagcatga tcgagatgct
    13621 ccggacgtcg ctgcggcagg acggctgcta cgacgacaag accatgtacc agatcatctc
    13681 ggagagcatc ctggcaaagg cctcggtgac cgaggacgac atgcacgagt gccgcgccgg
    13741 cctcgtgctg gagtacggcc acacggtcgg gcacgccatc gagtacaccg cctccggtgg
    13801 gctctcccac ggccaggcga tcggcctcgg catggtggtg gccgccgagg tgtcccgccg
    13861 gctgggtcac ctcgacgacc gggccgtcgc actgcaccgg gagctgctga cccgggcggg
    13921 cgcgatggtg accatccccg aggaggtcga cctcgacgag gtgatgcacc ggttgcggtt
    13981 cgacaacaag cgcggctacc tcagcgaccc ggccgagagc agcgcgatgg tcctcctcgg
    14041 tggactgggc cagccactgt ggcaggacgg ccgtccactg gtctccgtcc cgatggccct
    14101 ggtcggcgag gtcatcaacg agatcgcctg cccggagttg ccgaacttcg agctggtggc
    14161 accggctcag ggcgagcggg tgccggacac ggtgggtgct gccgatggtt gagcgtctgg
    14221 gtgtcgccgt cgtcgggggc gggttcatgg gtggcgtgca cgccgaggtc ctcaccgccg
    14281 atccccgggt ggatctgcgc tgggtggtgg accgcgacga gcgcgtcggc acggaactcg
    14341 ccacccgctt cggcgcacgt gccaccgcga ccctcgacga ggcgctggct gacgacgcgg
    14401 tccgcctcgt ggtggtggcc accccggccg ccacccacga accgatcgcg gcgcgggtga
    14461 tcgccgcagg ccggcacgtc ctggtggaga agccgctcgt gctctccacc gggcacgccc
    14521 ggcagttggc cgccgcagcc cgcgaacgcg gggtgacgct cgcgcacggt ggcaacttcg
    14581 tctacgcgcc gaagttcgtc cgggcccgcg aactggctgc ggaccgggac gcgctgggca
    14641 ccgtccactc ggtccgggtg gcgttccgga cgtccggccc ggacaccgac tggttccggt
    14701 cgaaggcgac cgccggtggc ggtgccctca ccgacctcgg ctggcacgcc gtggagctgt
    14761 gccgctggat gctcggcaag ccggccatcc ggtccgtcac cgcctgcacc cgccagctca
    14821 gcgccgcggg ggacgtcgag gaccagggcg tcgtcctgat cgagttcgcc gacggcgcga
    14881 tcggtcagtg cgacgtctcc tgggtctgcc ccggtggcga acagctcacg gtcgaggtga
    14941 tcggcaccga gggtctggtc accgccgacc tctggcaggg catgggcgtc gaggtgtaca
    15001 ccaacaccaa gttcggcgcg gtgtgggagc ccaaccaggg gtggctgcgc cccgagtggg
    15061 agtggatccg caacagcgga tacgtgcacc aggaccgtca ggtcgtggac gcggtgctcg
    15121 agggccggcc gatggagcac accccggacg acgcggtcgc gatcgtcgag gcgctcgagg
    15181 cggcctaccg cagcgccgcg ggcggacgga aagtggagac gaatgcctga caaccgtgcc
    15241 ccccggggcg tcctctcgat gacaccgttc ttcctctacg ccgaccacca gaagctgtgg
    15301 aagccacggt tcgacccgat gggcggcatg cacgtgttgg gccacgcgat cgtgacggag
    15361 atgggccggc ggggcttccc gcaacgggtc ctcaccatgg ccccacccgg cgtcccgaag
    15421 gacctccaga tcgcgccgaa cgtcaccgtg cacgcccggc gcctgccggt gttgccgatt
    15481 ccgtcgaaac tggagggtta cttcggactg gtcggggcgt gggcgaaggc cagcctgctc
    15541 tacgtggtgc gtaacaagga gcaactcaag cgggagatcg ggatcgtgca cgcgcactgc
    15601 gacggttccg gctcggcccc ggcctacgcg tacgccgcgg cgcaggtcct cgacgtgccg
    15661 atcgtgtcgc acatctactc ctgccggtca ctcacccagc acccgaccac ggtgttcgag
    15721 cgggtggccg acccggtggc caagtcggcg gagaagtacg tcatccagca ctccggtgcg
    15781 gtgctgaccc tcagcgacaa ggtccgcgag cgcatccggg acgagctgca cgtgccggac
    15841 gaccgggtgc accggttggc acacctggtc accgacaact tcgtcgggca cgacacgccg
    15901 gagcgccggg aggaactgcg gcagcggttc gggctgaccg acgacaagcc gaccgtcctc
    15961 tacgtgggcc ggatctcctc ggagaagggc gtcgactggt tcgtcaaggc cgccgccgag
    16021 atcgccaagc ggcgggactg ccggttcctg atcgccggtg acggaccgca gcgcggtgac
    16081 atcgaggcgc tggcgcggca gctcggcgtc gccgacaagc tggtcatcac cggcttcctg
    16141 ctccccgagt acatcccgtc gatcatctcg ctctcgacgc tcgccgtcct gccctcgcag
    16201 tacgaggagc tgggcgtcgt cgtgctcgag tacatgatga tgaagcgccc ggtcgtggcg
    16261 cacgacgtca gcggcgtaca caagctggtc gagcacatga agaccggcgt gctggtgccg
    16321 cccttcgacc ctccgaagct cgccgacgcc atcgagatgg ttctcgacga tccggacctg
    16381 gcccgtcgcc tggcagacgc cgccgagccg attccccagc gggagtactc gctggcctcg
    16441 gccggtgaac gtctggaggc gatctaccta tccctcatgg aggagtcctg agatgaccgt
    16501 cactagcaag atcgtcaccg gtgtcgcctt tccaccgtcg ctgttggcgg agaccccgcc
    16561 gatctcggtg gcgacgctca cggcctatct tcgcgacaag ggcatgccgg cccgtggcct
    16621 ggacctgaac gcggacttca acgagtacct gctcaaccgg gtcgagctcg agcaggtaca
    16681 gggcccggag aacagccacg agttcaccca gcccttcatc aagcagttct tcctgaacca
    16741 catcaccggc aactacttcg ccgagacgaa cttcgagcag tgggaactgc agcagcagtg
    16801 ccaggtggct ccggagagcc tctccatctg ggacccgccg ttcccgttct cgtactgtga
    16861 gttcctgtcg atcctgcggg acgagccgga acgcgtcgcg aagctggtcc gggacccgga
    16921 cgcgaacatc taccacgcct tctaccacga gaaggtcgcc ggccaggccg ccgagctggg
    16981 catgatgggc ttctcgatca tggggtacaa ccaggtcatc cccgcgctga ccctgggcta
    17041 cctgatgaag caggagaacc cggacctcta catctgctgg ggcgggccct gggtgacctc
    17101 cttcgcggac atgctcatcc cgcgtctgga ggcctgcccg gagctgggcg acctgatcga
    17161 tgcgctggtc gtccgggagg gcgaggagcc gctgctgaag atggccgagg cgttgtcccg
    17221 cggcgagcgt ccggtgggca tccccggcgg ttgcaagccg atgtcggagc agagcgtgct
    17281 cgacaccaag ccggtcggcc gcaagctgct gctggagatg tcgaagcccc gggaaaacgt
    17341 cccgaacacc cactggcgga ccgaggacgg cacctacgag cgcagcggtg acatctcctg
    17401 ggtcgccgac atgaaccaga tcccgacccc ggactacagc gacttcgacc tgtcgctgta
    17461 caccacgttc cgggagggtc agggcagcct ggtgctccag ggctcgcggt cctgctacta
    17521 catgaagtgc tccttctgca acgcgatcac caacttcgcg ccgtggagct accgggagcg
    17581 cagcaccgag aacatcgaga aggacatcga caccttcctg gagctgtacc cgggcgtcgt
    17641 gcacttcgac ttcgccgacg cggtcttccc ggccaagcgg ctggtcgaga tcgccgactt
    17701 cttcatcgag aagaagcgcc cggagctgtt ctgggaggtg gacgtccggt tcgagggcaa
    17761 catcgacaag gccgtcctga ccaagatgcg cgactcgcag ggcaagctgc gcttcggcct
    17821 ggagaccgcg aacgaacgcc tgctcgacct ggtccggaag ggcaaccgga tggacgtcgt
    17881 ccaccggctg ctccaggaca gccgggaact gggctacaag ccgttcctga tgaccatcgt
    17941 cggcctgccc accgaggagc ggaacgaggc cgaggagctt tacgagttcc tcagcgagta
    18001 ccacgacacg gtgacgtacc agatcgccga cttcatcgtc gagcggaact cgccgatcca
    18061 gctccgcccg gacgagtacg gcatccacat cgaggacgac gaacagcaga gcttccacca
    18121 caacctgcac ttcacccgtc gcgccggcta cagcgacgag gaggcgcagg aggtgtaccg
    18181 ggacatcctg gtccgcacca tgcagcggtt caagggtgcc cgtgaggtgg acgtggagca
    18241 ggagcggagc cgggtggccc cggacgactc ggtctaccga ctgagcctgc gggccggctc
    18301 cttcgcattg gagaactact gggtgaagca caacaacctg ccgttcgagg gcctggtgcc
    18361 catcggctac aaggtccagc agcagtggac cgacatgacc aacaagggca cggtcttcga
    18421 gatcgacccg gacatcgccc tcggggccct cgccggggca ggtagccgct gatgatggag
    18481 aaactggcca ttctcggtgg cgacccggtc cggcagcggc cctggccgga gtggccgcac
    18541 gtcggcccgg cggacgtgga gcggctccgg ggcgtcatcg agtcccgcaa cctcggcggc
    18601 atccccttcc cgaacaccct gcaccagcag ttcgccgagc ggttcaccgg caagctcggg
    18661 gcgaagtacg gcctcctggc ggccaacggc acggtgacac tctcgatggc gctgcgcgcg
    18721 ctcgggatcc atgccggcga cgaggtgatc accaccgcct tcacctggat cgggacggtc
    18781 gccggcatcg tgcacgtcaa cgccgtgccg gtgctggcgg acatctccga cgacagctgg
    18841 tgcatcgacc cggtgaaggt cgaggaggcg atcaccgacc ggaccagggc gatcatggtg
    18901 gtgcacctgg gcaaccaggt cgccgacatg gacgcgctgc tggacatctg ccgccggcac
    18961 aacctgctgc tgatcgagga ctgcgcgcac gcccacttcg cggagtggcg cggccggtgc
    19021 gtcggcacca tcggcgacgc cggcagctac agcttcgaga ccagcaagat catgacctcc
    19081 ggtgagggtg gtttcctggt cactgccacc gaggagacgt tccaccgggc catgtccctg
    19141 gcgcacgtcg gccgcaagga ggccccgtac gacaagttcc cgggccgggt gttcggctgg
    19201 aaccaccggg ccaccgagat gcaggcggcc gtcctgctcg gtcagctcga ccagtacgac
    19261 gacctcgacc ggcagcggac cgcgatggcg gaactgctga ccaaggggct gaccgagatc
    19321 ggcgggttca tcccgctgcc cgaggacccg cgggtcaccc ggcggcagcg gtacgagctg
    19381 ctcttccggt tcgacaccga ggcctgggac gggctgcacc gggacaaggt gctggaggcg
    19441 atcctcgccg agggggtgga gttcgaaggg aacaccttct acccgccgct gcaccgcgac
    19501 gagctgttcc acatcaccgc cgacgactgg cctgcgatcc gggagcggta cggcgagaag
    19561 atctccccgg acgcgttcca cctgccggtg gcggagcggg tggccttcga cgaggcggtc
    19621 tggatccacc actccctgct ctcggtggag ccggaggacg tccaggacat gctggatgcc
    19681 gtggtcaagg tccgggaaaa tctgggggcg ctgaagaaga gcctatgatc ggttcatggc
    19741 tctgacgaag ctcggtcggg cggacacccc gcccgaccga tccctcgaaa cattcccgat
    19801 caccgacagc tcgcaggaga tcaccatcga ctgccgggag ttcacctgcc gctgccccat
    19861 caccgggcag ccggactggg cgacgatccg gatcgactac cggccgggtg accggggagt
    19921 ggagaccaag agtctcaagc tctacctgga gaccttccgg gacgagggga tcttccacga
    19981 gcacctggcg acgaagatgc gcgacgacct ggtggcggct ctcgagccgg tcttcctcaa
    20041 ggtcaccgtc gacttcaacg tccggggcgg catcgcactg gcggcgtcga gcacgtacca
    20101 gcgctgaccc ccgggcgggc tcgagaacgg cggtggcggt ggttcctcct gcaacacgcg
    20161 ccgccctccg ccggcgatca gcgatccggc cggaccgcgt cacaccgaga tctgccacac
    20221 gcgggcggat cggcgccgga agaccgaccc gcggatcagc tcagaggaac tcgtcgagca
    20281 gctggaagta ggccagcttg tactcgtcga cggtggggca gccgtaccgc cggagaagtg
    20341 ctcactgtgc gccgccccgt agccccagac gtcgtcctcg ccgatgttgt acagcgccag
    20401 agcgagatcg aaccaccggt cggagacgcc gagccgatcg acgtcgatga tgccggccag
    20461 ctccagcgtg tcgggatcga tcagcacgtt gtccaggcac aggtcgccgt ggcagacgac
    20521 gaggtcgtcc tcgggcggag gcaccttccg gctcagcttg tcccagagct gctgggccgt
    20581 ccagccctcg tgcgcggtgt ccacgtccgc caggtcgatt gcgcccagct cgatcgacga
    20641 cttcgcctcg tggatcaggt cgggcagccg ccgttcgaag ggacactcgg ccacgggcag
    20701 gtcgtgcagc cgccgcgcgg cgtcggccac cacctcgatc acccgccagc gctcctccgg
    20761 ccgcccgggc agggtccggg tgaccaccca ctgaaggtcg tcgttggcac ccagcgccac
    20821 gacctcggga acgggcagcc cccggtcggc cagccaccgg agccgctcgg cctccttcac
    20881 cgggttgaac cgggggtcgt cggggtgccg gggcagggtg gtcttcacgt agaaggacgc
    20941 cttctccccc acgcggtaga ccgtcgcgcc ggacgagcgt tcgcccaggc actcccgcgg
    21001 gtcgtcccgg tcaccccaac cggccaccgg aatcggcgcc gctgccacca tcgcacgtcc
    21061 tggttccatc tcctcgccgg tcgtcagctg gcggggtcgg ggatcaggat gggcttgatg
    21121 ctgcgatccc ggttgacgac cttctcgatc gtcccgtcga tcatcgcgtt ggtccgctcg
    21181 tcgtcccgca gcaacccgcc gaacgcccac tccgcgaagt ccaaccaccg ctcctgggtg
    21241 atctcgccac ccgaggtcgg agcgatgtcc gggcgatccg cgatcacctg acgcgtcgcc
    21301 ttcaggaacg ccgtcagcac gtgatccacc gcggcctcgt cgaacgccgt cgtcaccagc
    21361 tgcgtcccgc tgtcctcgaa gtacaccccg tactcgtgcg ccgcctggta gatctcccag
    21421 cccaggtcgt cgttcggcag caccacgtcg aacatcaacg ccgggccacc cacccggttg
    21481 gcgatcccct ccgccgtcag gatctccccc atcccgtccg ccagcaggcg gcccatccgc
    21541 tccgcgtgct cgtagacgcc gggcgtgtcc aacacgtcca gcaccgccag cgccgccgcc
    21601 atcggcggca cctcccgcgt gtaggttccc tggatacccg ccacgtcgta cgcgtcgatc
    21661 agatcccgac ggcccatgat ggccgccagc gcgtggccgt tcgccagccc cttgctcatc
    21721 accaccaggt cggccggcac gtccaacccg tgcacgccct tcggccccgc ccggagcccg
    21781 gtgtacacct cgtccagcat gaacggcacg tcgtaccggg cgcacgtggc ggccatccgg
    21841 cggtagaagt caaggtcgaa gtagagcagc tccggcgaga cgagcacccc ggcgacctcg
    21901 tcgccgaatg cctccagcat cttctccaga gccttctcgt tgtagccgaa ccccaccacg
    21961 ccggaggtct gctgataccc gaacgtctcc gacgccaact gccactcgtg ccacccgtgg
    22021 tagccgcagc tcaggatcaa ctcgcgaccg gtcgccgccc gcgccatccg caccgccatg
    22081 gccgtaccct cggtgccggt ccggtggaac acgaccttct ccgcgcacgc gtaccgctcg
    22141 cacagccgct ctgccaactc cacccgcggc accgacagcg tcgaggcgaa cgccgtgccg
    22201 tagtcccgga tctgccggat gatcgcctcg acgaccgcag ggtgccggtg gcccaggatg
    22261 agggtgccac tggaggccgt gaggtcgacc atacggttgc cctcgacgtc ggtgatccac
    22321 gcgccctccc ccgactggat catggaggag aaccgggtct ggacgtcgta cttctccgcc
    22381 gcggtcgccc gccgggcccg ctcgatcagc ccgcggttcg tcaagttggc agaatccatg
    22441 tcctggctac cttctctcgg cgattgatga tcttgcctgg ggacgccgcg gattgcgtgc
    22501 cgagccgtcc gacctgcccg acccgttgcc gggcggtcgc taccggcgat ccccaaagga
    22561 caccgcgaac gtcagcatat agcaccgcaa ctatgctcgg tatggccgaa aagctcttga
    22621 cgcttcgtgg ttaaacgcac cgtcgcatcg cccggacagg gcggagtaac cgccggtcat
    22681 acgtttccaa accgtcgaac cggggcgctc cagccacacc ggagagcgcg actgcagcct
    22741 gtccggcctc actcaacgtg gtgtcgacaa ccggggcgga cgccagccgg ccgggcgacc
    22801 gctgggcagg ccaaccgccg tgcggggcca cctccgggcg ccggctcgaa gcggggtcgc
    22861 ggctgcggac aaccggcggc cggcccgacc agctcggcac ctggccgccc tcgaccagct
    22921 ggattgaatg aggagagcag aatgaacggt cagcaaccac gccgggcgtt ttccgtagtt
    22981 tcgccgctgg ccgccgattg tcagcctcga cccggcaacc attcacgatt gggctccacg
    23041 gtccctgtgg tgtgccgcgt ttcgcgcaca cccggcccag accgttcgga aggcggaaat
    23101 tccccgcacc attgtcgcgg ccgccggcgc agtttcgtcg tacgagccgg cgtgcgacgt
    23161 cccgatcgtc cgtgggcggg ggcgccggcc ccgtcccgca ccggccgccg gccggccggt
    23221 gcggaacggc tccgtcggtc aggtgccggt cgcgccgtcg atcgtctgcc ggatcaggtc
    23281 ggcgtgaccg ttgtgccggg cgtactcctc gaggatgtgc accaccgtgg tccggaggtt
    23341 gagcacctcg ccctcgtcct cgtaggtgtc gccgaggtcg cgcagcgaga acgccttgcg
    23401 ggtcagctcc acctcctgcc ggaagaggtc gaagtcggcc acgacgtcgg ccgtggccac
    23461 gtcgtcgaag gcggcgtccg gacgctcctc ggtggagtac gggtcctcgg ccgtctcgcc
    23521 ggtgaagagc gtacgcagcc agcgctccag ctcggtcatg tggcgcacca gcccgagcag
    23581 ggtcaggttg gtcaccggga tgctgttggt cttgagctgc gcatcggtca ggcccgagca
    23641 cttgaacagc agggtgtccc gatggtagtc gagccagccg gccagtacgg cacgctcgtc
    23701 gcccagggcc gggtctggcc tccggtcgac ggcaggggcg gtccaggtca tggggttgtc
    23761 cctttcggta actgagttgg gtggggatcg gcggccgtca cccggcagca gggtacgccg
    23821 ggaagggcag gatgcgggct gtaccgtcct ggctggcggt gacgatccgc gagccggtgc
    23881 ggtcgaagcc catgttccac actggagcgg tgtgcccggt ttcgagctct ccgacctgct
    23941 tcccgctggc cacgtcccag acccgcaccg tgcagtcctc gcccgcgctg accagcagcc
    24001 ggccgccggg gtggaaggtg accccgtcga cggcgtcggt gtgcccgacc agcggaccga
    24061 ccgccggccc gcccgccgcg tggtcccaga tccggacggt caggtcgtcg gacccgctgg
    24121 ccaacaatcg cccgtccggg ctgaaggcca cgctgaccgc acccttcgtg tgcccgacga
    24181 gcgggttgcc gaccggttgg ccggtcgcag tgtcgtagag gcgcaccgcg tcgccggtcg
    24241 aggcgaccag atggccgtcc ggatggaagg ccaccccgtc gatctcgtcg gtgctcgcgg
    24301 tgaggggctc acccaccggc tcgccgccgg gcaccttcca cagccggacg gtgtggtccg
    24361 cgctgccggt ggccagcagg gtcccgtccg ggtggaaggc cacgccgtag accccggccg
    24421 tgtgtccgac gaggggctca ccgacctgcc tgccggtggt cacgtcccag atccgggcgg
    24481 tccggtcctc gctggcgctg gccaacaggc gaccctcggg gtggaacgcc acgagccaga
    24541 tcgtgtcggt gtgcccggtg agcgtctcgc cgacctgctc accggtggtc gcgtcccaga
    24601 gacggatggt gccgtcctcg ccgctggtgg cgaccaggtg atcgtcgggg tggaagaccg
    24661 cgccgatcac gccctcccgg tgcccggtca gcaccaggga cggctgggtg ggggctgctg
    24721 ccgactccac ctgtctgctc cgtttctcca cgtgagggtg tcggggtcag ggggtggccc
    24781 ggggaactcg ccaggtcacg cgtcgccgcg cgctggacgg ccgggaccag gtgccggggc
    24841 gggtcccgtc ccggcggtgg gaacggtcgg gtgaccggtc cggatgcggt gcgccgtccg
    24901 ccgggttccg ggacctgacg gacggcgcac cccgtcggca cgtcagctgg tacgtgcccg
    24961 acggttgaac agcgcgagga ccgccggcag ggcagcgatg acggcagcca cccagaacgc
    25021 ccggcgcatc ccctcgaccg ggtcggcggg cgtacccgct gcggtgacca gcaccgccag
    25081 gccgagcgcc ggaccgatct gctggacggc ctgcagcacg ctggacgccg cgccggtcac
    25141 ctccggcgcc acgttggaca tgatcgaggc ggtgaccgag gcgtagatca gtccggcgcc
    25201 gaagccgccg agcaccagcg gaccgagcag cgaggtcgcg tagccgccgt cggcggagag
    25261 ctgggtgagc cagagcatcg cgacggtggt gagcaccgcg ccgatcccgg ccacgacgct
    25321 cgggccgagc ttcggcacca actgaccggt cagcaccgcg gcgaccagga ccaggatcgc
    25381 cgccggaacg aaggcgaagc cggtgcgcag cgcggagtag ctccacaccc cctggaagta
    25441 ctgggtgagg aagaagaaca gaccggcgaa ggcggccggg aagaacagca gggtgacgaa
    25501 gccgctggcc cgtacccggt cggtgaagag ccgcagcggc agcagcggct gccgggcccg
    25561 ccgctcggcc aggagcagga cggtgaagag gaccgccgcc acggcgaggc agaccaggac
    25621 gaccgggtcg ccccaactct cggtcgaggt gcggaccagg gcgtacacca gggcgaccat
    25681 cgcgccggtc gaggtcaccg ccccgacgac gtcgaacgag ccgcgctgcg gctggctctc
    25741 cttgaccgca cccggcgcga gcaggagcac cagcgcgacc acggggacgt tgatgaagaa
    25801 gacccagcgc caggaggcgg cgtcgctgag caccccaccg atgatcaggc cgagcgtacc
    25861 gccggcggcg gcgatgccgg tgtagacgcc gatcgccttg ttccgggccg cgtcgtcggt
    25921 gaagttgatc ggaatcaacg agagcgacgt cggtgcgacc agcgccgccc cgacgccctg
    25981 cagggcgcgc gcggcgatca gcacctccgg ggagggggcc aggccgcaca gcagcgaggc
    26041 gacaccgaag atcaccagcc cgacgaggag cacccgccgc tggccgacga tgtcaccggc
    26101 ccgaccgccg agcagcatca ggccgccgaa ggccagggcg taggcgttga ccacccagac
    26161 cagtccggtc ccgctcatct cgagactctg ctggatctgt ggcagcgcga cgtacaccac
    26221 cgtcgagtcg aggacgatca tcaacgcgca ggcggccaga agtgccagca cgagtccggg
    26281 cttacggggg cccgccgcgt cgggctgctg gcgcgccgcg ccggtcgcct gtttggccgt
    26341 gtcagacatg gacagcctca ctcatcatgg tcggaatcag gatcggccaa tatatgcgtt
    26401 tcggcgtgtc cgtccgaagg ccgaacatcg gcccgtccgt ccaccgtcga cgattgttcc
    26461 agccggtacg gcgtggccgg cgacgcggtg ccgccgttcg gacggcggca ccgcgctccg
    26521 actcgtacgg tggctactcc ccgcgcaggt cgaagacgac ccggacggtg ccgtcggtcc
    26581 ggttgatcgc gcggtcgatg gccgggccgt agtcgtccag ggtgacgatg tcggtaagga
    26641 tcggccgggt gtcgatcgcg ccgttcgcga gcaggtcgac ggcctcccgg tacttgccgc
    26701 cgggccccat gacgccgacc aggctggcgt acgacaacgg caggcgggcg gtctccagcg
    26761 cgtgctcggc gcccacctgg tagccgacca ggcagacccg accgccgggg cggaccaggt
    26821 caagcgcgcg gaccacggac tccgggtcgc cggacgcctc gaacacgacg tccaccttgt
    26881 ccgcgtagct ggtgagctcg ggcagctcac tggggtgcac cgcagccgcg gcaccgctct
    26941 cctcagcgat cttgcgtcgc tcggcgacca gatccgtggc gagagtgacc gtggccccgg
    27001 tcgccttggc ggactggagg atgagctggc cgatgccacc cgcgccgagc accgcgaccc
    27061 gctcggcggg ccgcaggttg atccggtcca ccgcgtgcag cgccacggcg agcggctcgg
    27121 tctggctcgc cgcggcgagg tccatcccct cggggagcgg gtagaggttg gtcatcggta
    27181 cggccacgta ggaggcgcag ccgccgtcga cagtgaagcc gatctcgatc aggttctcgc
    27241 acatcaccgg cagcccgtcc cggcagggcc cgcaggtctg gcagccgacg atcaggtcgc
    27301 cggtgaccgg ccgcccgacc caggactcgt accccttcgg ggcggagtcc accacgccgg
    27361 cccactcgtg gcccggcacg atggggtacc ggttgccgtg ccactttcct cgatagagcc
    27421 agaggtcact gccgcagagg cagcagtagt gcaccttgac gacgccccat ccgggaggtg
    27481 cctccgggcg gggagtgtcg atgatctgag ccttgtgtcc gccatggaac tgtagagccc
    27541 gcattcgtcc ccccacgcgg ctgtgacttg ttctccggac accttagagg ccggttgatc
    27601 agggctcaac agttccgctc tggattttcc atgttgacgg agcatccata gccgactatc
    27661 gtcccgaaag gatcctccaa cctctgggag atttgacggc cggttccccg gtgacgtcct
    27721 ccagcatcgg ggcttggctg tgtcgaggtc gcgccgcggt cgtcggacac gtttgggggt
    27781 gtggcggtag acatcacgag aactgtcgtc gtgccgcgtc tcgaaaacgc cgttctccac
    27841 tgccgccgtc gcgtcgcatt tccggcccgt ccatctccgc accacctttc ggccatctgg
    27901 tgatggtcta tgcccatggg cgggagcggg gcccggtacc gaccgggtga gtcgccgcga
    27961 ccggtgaccg gagagccacc accgggacgt cgacacctga gcgaaccctt actccttcac
    28021 gacgcctgtg ctcgtgtgct cccggcggga cgacgaaccc tctcccggac cgcttcccgc
    28081 gttctcccgg cagacgcgac gatggtccgt gtccggagcc caccacaaca cgaccggcgt
    28141 ccgtgctgac cagttcaagg atccagatga actccgtaca ctccgacctc aaggtcgcca
    28201 tcgtcgtcgc cgacatcgcc atcgtgctga tcgtcggctc actgctgatc atgctgttcc
    28261 gtcggctcaa gcaaccgccg gtcatcggtg agatcaccgc tggcatcgtg ctcggaccga
    28321 gcctcctcgg gctgctgccc ggagacgtca ccggctttct cttcccggcc gagctccgcc
    28381 cccacctctc gatgatctcc caggtgggac tgctgctctt catgttcctg gtcggctggg
    28441 agttcaacgg tcaactgctc aagcgccgct ccgggtcggt cgcctcggta tcgctctccg
    28501 cgatcgccct cgccttcacg ctcggtatcg gcgcggccgc gctgctctac gaccggcacg
    28561 acgtggtcga cggggagagg gtctccttcg gctatttcgc cgcgttcctg ggcatcgcga
    28621 tgtcgatcac cgcgttcccg gtgctggccc ggctcctcac cgagaccggc ctggcccgga
    28681 cccgggtcgg agccctctcc ctggccgccg ccgcgctgga cgacgtgatg gcctggaccc
    28741 tgctggcctt catcgtggtc atcttcgggg ccggcggtga cggtaccggc acgctggtgg
    28801 ccgtcctcgg gctcttcctg ctctacgtgg cgttgatggt gttcggggtc cggccgctgc
    28861 tccgccggct cgtcgcccgg atcatccggg gcggcacggc ctcgcccttc ctcgtcccgc
    28921 tgatcgccgc cggggcgttc ctctccgcct atgccacgtc gtggatcggg gtccacgcgg
    28981 tcttcggggc cttcgccttc ggtctggtga tgccccggga gccacgggcg ttgctcgccg
    29041 agtccctgca catcccgctg gagagcgcca cccgcctgct gctgccgatc ttcttcatcg
    29101 tcaccgggct caacgtcgac atcggcgccc tcggttggac cggtctgggc gagctggcga
    29161 tcatcatggt cgccgcctgc gtcggcaagc tcgtcgccgc aggcatcgcc gccaggttgt
    29221 ccggcatgaa ctggcaggag tcctacgcgg tcgggctgct catgaacacc cggggcctga
    29281 ccgagctggt gatcctcaac atcggtctct ccctgggggt gctggacggc gagatgttca
    29341 ccatgatggt gctgatggcc ctcctcacca cggccatggc ggtgccgctg ctgcccaagg
    29401 ggctgccccg ggcgccgggg ggcctgttcg gcgtcccatc cgtcaccgtg ccgttcggtg
    29461 cgaccacccg gcgcgcgccc gcgcagggtg acgccgcgga ctctgccccc accgggcacg
    29521 aggtgccgtc cggcaagtcc tgaccgacag ccgcgacaca ccggcgacgg ggatgccctg
    29581 tcgtcggtgt gtcgcgtgcc gcagggaaag gccctgaccc gggcgtacgc ctgaacgctg
    29641 agtaggctta ccgccgggta cgtccgtgcc cgtcgacgag gtggaagggt ggtgtggcgc
    29701 gtgccgaccg ggaagcgcaa ggccgtggtg ctgctcagcg gtgggctcga ctccgccacg
    29761 gtgctcgcca tggcggtgca cgagggatac gaggcacacg cgctcagctt ccgctacggc
    29821 cagcggcaca ccgtcgaact ggaggccgcg gcccgggtgg ccaaggcgct cggcgcgacc
    29881 cggcacgtgg tcgccgacat cgacctgcgg gtcttcggtg gctcggcgct gaccgacgac
    29941 acgctcgtcg tcccgcacca cgccagcgcc gacgagatgg gcgacgagat cccggtcacc
    30001 tacgtgccgg cccgcaacac gatcttcctg tcgttcgccc tggcctgggc ggagaccctg
    30061 gacgcctcgg acatcttcat cggggtgagc gcgctggact acagcggcta cccggactgc
    30121 cgcccggagt acgtcgccgc gtacgagacg atggccaacc tggccaccaa ggccggcgtc
    30181 gagggccggc agcggctgcg gatccacacc ccgctgatcc agctcaccaa ggccgagacc
    30241 atccgccgag gcctggaaat gggcgtcgac tacgcgtgga cgcacagctg ctacgacccg
    30301 gtcgacggcc gggcctgcgg cacctgcgac tcctgcctgc tgcgcgggcg cggattcgcc
    30361 gaactcgggc tgaccgaccc cgccctgtcc accaccgggt gaccggcgtg taccggatca
    30421 aggagatctt ctacaccctc cagggtgagg gcacccacgc cggccggccg gcggtcttct
    30481 gccgcttcac cagctgcaac ctctggaccg ggcgggagga ggaccgacac cgggcgatct
    30541 gccagttctg cgacaccgac ttcgtcggca ccgacggccc cggcggggga cgcttcgcca
    30601 ccgccgccga gctggccgcc gcagtcgcca cggcctggcg gggccaggcc cacccccgca
    30661 gccgcccgta cgtggtgtgc accggcggcg agccgctgct gcaactcgac gaggcggccg
    30721 tggccgccct gcacgaggcg ggcttcgagg tcgcggtgga gaccaacggc acgcgtccgg
    30781 caccccccgg cctcgactgg gtctgcgtca gccccaaggc cggcgccgac ctggtgctca
    30841 cccggggcga cgacctgaag ctggtctacc cgcagccggg agcggagccg ggacgcttcg
    30901 agcacctcga cttcacccac ttcatgctcc aaccgatgga cggcccggac cgggtcgcca
    30961 acaccgaggc cgcggtgcgg tactgcctgg agcacccgca gtggcggttc agcctgcaga
    31021 cccacaagta cattggaatc gcctgatgga gatcttccgg gagttcacct tcgaagccgc
    31081 gcaccggctg ccgaacgtgc ccgaggggca caagtgcgcc cgcctgcacg gtcactcgta
    31141 ccgggtggcc gtgcacgtca gcggcgacgt cgacccgcag gccggctggg tgatggactt
    31201 cggcgacctc aagcgggcgt tcgagccggt acgggacgaa ctcgaccact actacctcaa
    31261 cgatgtgccg gggctggaga acccgaccag cgaggtgctg gcccgctgga tctggcaccg
    31321 gttggccgac cggttgccgt tgtcggcggt gtcggtccgg gagacctgca cctccggctg
    31381 cgtgtaccgg ggcgagggct gaccctgagc gtggcggggt cgggtcggca gcggtgatct
    31441 gacggcggcg agaaggacat gcgaagaggg gccgtgcacg ctggcccctc tcgtacctgg
    31501 tcacatccgc atgtcgccga cccgctcctc cgagccgacc atgacggcct gcccgtcggt
    31561 cgccatcgac gcgtcggagc ccgccatcga catcatggag tcgtccgcca tggacgtacc
    31621 cggcatcgcc ccatcggtga tgttcggcca cagacggacc gggccgtccg tctgctccgt
    31681 gcgcagttcc ggcggcgtgg gctgcagcgg ctgcagaccg acgagctgca accgccccgg
    31741 gaagacgttc agccggccga agtcgtccag cctgttgctg atcctggcga cggcccggcg
    31801 atgccgccgc gtcgcctcca ggaccttctc ccgggccacc gcgtcgagtc gcttcccgtc
    31861 ctgctggtcg gtgcccgctc tgacgtgccc cggctgggcg aagtccgcct cgctgacccg
    31921 ctgccaggcc agggtgtcct cccggatgct gtccgcgagc tgccggaccg cctcctcgtg
    31981 gctgaccccc tcgtcacggg cctgccagta ccggtacacc cgggcggcgt gcccgaccat
    32041 gccggtgatg gagcccccgc tgttcaggaa gctgccggtg ccgaacgagt cgccagcgac
    32101 cacgcagttc ggcgccacca gcgcgtccct gccgatcttc tccacgttgc tgaccagctt
    32161 gggagtggcg aggatgaggg tacgggcgag ctcccggcgc gggatctcgg tgagcaggga
    32221 gacctggtcg aggaagtagt cccggatcag gtaccggtgc gcgccgaagt actcgaccga
    32281 actctggctg gtgcccgggg gcaccatgcc cgcctggacg gggtcgaagg tccggtagtc
    32341 cggcacctcc aggatcgtcc aaccgctctc gctgaatccg tcgtgcccga gggtcatctg
    32401 ccggatccag tactcgttgc cctgcttgtc gaagtccgag gcgatccgct gccgcgaggt
    32461 ggcgccgacg tagacggcga tcagcccgac gacgtagtcg gcctgcgcca cgaccggacc
    32521 acgaccgtcc ccgtggtcga tcctcaccag atcctgggtg aagccgagcc gcttggcgtc
    32581 gacgctgtcc acgccctccg cgatcgagat cagcccaggc gtgcccaggt cgaccagctc
    32641 gctgccccgt acccggatcc gccggtaggt gcccttctcg tcgatctccc ggaccgcctc
    32701 gatccggacc cgcacccggc cgtccgcgtc ccgggagaag ccgtcctcca ccgtctcgtc
    32761 gtcccggccc agccagcgcc gccagccggc cggccggctc gggtgcgcca cccggtggta
    32821 cctgaagatc cggcaccgcg gctcccgacc ggcggcgagg tccatccgct cgatcccctc
    32881 caggtaccgc cgaagcatga tcagcaggtc ctcggcgttg cactggaagg ccggcgactc
    32941 ggcgagaaca tcgtccatgc tgcggccgac ggtctccggc ccgtgctcca tcgacggggc
    33001 cgggggacgg atctcggtga ccgtccggtg cggcttgccg tccacccacc ggtcgtcgac
    33061 gacctccgcg atccggacgt gaccgcccag acaggagtcg gcccacccga agaggatctc
    33121 gtccgcccgg gcctccgcgc cgtcctcggg gtccagcttg tagaagagct cgtgcaggag
    33181 gaaccgctcg cccgtgaagg tccgggggat cccctcgtcg ccgtaccgtt ccatcatcag
    33241 ccggtcgatg accgccaaat ggtggtagat gtccgcgctg accttccact gggtcagggt
    33301 gaggtacggg tcgccccgca gctcgacgcc gaccacccgt cgacccatgg cgatcgacca
    33361 cagcatcgcc atcatgttcg ccccgccgag accgacagcg aggaagtccg ggtccgccgc
    33421 accggtctgg tcgaccttcc ggaggtccgg cgcggtggtc gtctcgtcga gcgactgggg
    33481 tgccgtcttc ggcacctcgc tctgcacggc gaagatggcg agcactatgg cggccaccat
    33541 cgtgccgaag cccaccagga acgccatctg gaagccctcg gtgagggcca ccgcggccgc
    33601 ctcgccctcg gccagcgccg actcggcgac gttcgccgcc accggagcca gcactgccag
    33661 accgagtgcc gagccgatct gctgggtggt gttcagcaga ccggatcgga tcccgctgtc
    33721 atcgagcgtg gcgtcggcga gggcgatccg cagcaccggc ggcgtcgcca gacccgagcc
    33781 gatcccgatg agcaggatgg ccgggagcac gtcgacccag tagctgccgt cggccgggat
    33841 ccgggcgagc agcagcaggc cgagtgccat cagcgccatg gccgggacga gcagcacctt
    33901 ggcgtcgttc ttccggatca accgcggagc gaccttcagc gagccgatcc cgatggcgag
    33961 cgcggccggc acgaacgcga agcccagctc gtagaccgag aagccgagga cgttctgcag
    34021 gtagagcgca cagaggaaga acatcgccgt cggcccggcg atcatcaacg cgaggacgac
    34081 gttggaccag gcgacgttgc gggcccggag gacgctcgcc ggaaccagcg ggttggaggt
    34141 acgccgctgc cacaggacga atccgaccat cagcagcagc gccacgccgc cgaggagcgc
    34201 cgtccggccc gcgccgctgt cggcctgcac gatggtgtag accgtcagca tcagcgagcc
    34261 gaccagggcc accgcgccga tccagtcgat ccccttcccg gccttggcgt cccggacgtt
    34321 gtccagcagc cgggcgccca tcaggatggt gaccagcccg atcggggcgt tgacgaagaa
    34381 gatccagtgc cagctcagcg acgcggtgag cgccgcgccg gcgagttggc cgatcgcgga
    34441 ccccgaggcc gccacgaagg cgtagagacc gagcgcgcgc gcctgctccc ggggcttcgg
    34501 gaacatgttc acgaccatgc tgagcacgac cgcggtggtc agcgcaccac cgacgccctg
    34561 cacgaaccgg gcaccgacca gcaccgcctg gtcggtcgcc aggccgcaga ccatcgaggc
    34621 gacagtgaag acgctgagcc cactgaggaa gacccgcttg gtgccgatca ggtcacccag
    34681 ccgaccggcg aggagcagca acccgccgaa ggggatgagg taggcgttca ccacccaggc
    34741 caggttggcc tgggagaacc ccagtccctc ctggatggac ggcagggcga cgtacaccgc
    34801 ggagccgtcg atcacagaga tcaggatgcc cacgcagagc acgatcagcg cgagctgacg
    34861 ctcccgcagg ctccgcaacg ggtgcgcggt gtcgcgtagg acgaccgtct cccccgaggc
    34921 gccgtaggag tcgcctcggg gggtggtgtg cagaacggtc acgacgccga acccgccccg
    34981 ataccgacgg gctcccgcat ctgcgcggaa tcctcggcgg ccatctccgc gtcggcggcg
    35041 ccgcacgtca tcggccgctc ggccggatgg gtctcgagga tcggcggcag gtcgctggtg
    35101 tgcagccgcc cactgcgcac cgcgagccgc cgccagtcgg acgggtccag cgggacgagc
    35161 gagtgccggt gccggcgcgt ggcgtcgatc gtggtggccc gctcaccgga cgaacgcccg
    35221 gtctgcttct cgatctcccg gatccgctcc tcaccgaagt tgatcggcac ggcctggctg
    35281 aactcctgcg agctgacctg gagccagccg agggtgtcca ccttgatctg gtcggccagc
    35341 tcgcggatcg cctgctgcgg gctgaccccc tcgtcacggc gctcccagta ctggtgcact
    35401 cgggaggcgt gccccaccat gccggtgacc gcgccaccgc tggtcatgaa gtggccgttg
    35461 ccgaaggagt ccccggcgac cacgccgttc gcggcgacca gggcgtccgc gccgcacttc
    35521 tcgaccaggc tgaacagctt cgggccgtac gggctctgga ccctttcgag gtccgacacg
    35581 ggcaactcgg tgatcaggga gacctgctcc aggtagtact cccgcagcaa ctgctggtac
    35641 gcgttgaggt actccttcga ccgcttcggg gtacccggcg ggacgaggcc ggccaggatc
    35701 gggtcgaagg tcttgaagtc cggcacctgg acgaggatcc agcccacctc agggtcgtcc
    35761 tcgtggccca ccgcgatctg gcggacccag tactcgttgc cctcacggtc gaactcggag
    35821 gcgatccggc ggcggagccg ggcaccgacg tgcaactcga ggaagccggc gaggtagtcc
    35881 gcctgggcca ccaccgggcc gcggccgtcg tggtggtcga cctcgacctc ctcctgccgg
    35941 aagccgagcc ggtccgcgtc gctgctgtcg aagccctgcg cgatcatgaa cagctcgggg
    36001 acgcccaggt cgatcagtgg cgagccgggc ttgcggatcc ggcggtaccg gccccggtag
    36061 tcgagctcct ggacctcctc gatgatgagg cgcttacgtc cgtccggaag gctgacgaag
    36121 ccgtcctcct ggcgcatcca cttgaggaaa ccgtccccgt cgccctcgtc accgacggcg
    36181 acccggtgcg acaggaagag ccggacccgc ggcgtgacac cgcgggcgat gtccatgtcc
    36241 tggatcatct ccaggtagcg acgcagcatg accagcacct cggaggcacc ggcctggaac
    36301 gtcgacgggc cgtcgagcac ggtcaccatg tcgcgaccga tcttggcggg gtcgtgttcg
    36361 gccggcggct tcgacggatt gaggacggtg agcacccgct gcggcttgcc gtccacgtag
    36421 cggtcgtcga tgaactcggt gtagtggatg agacccgaga cgtgggcctc ctcgacaccg
    36481 gcgatgcact cgtcggcgta cacgtcgccg ggctccgtga ccgggctgtg gaaggtctcg
    36541 cggagcttga agagctggcc gtcacccttg cgggggatgc cctcctcgcc gtaccgctcc
    36601 agcatgagct ggtcgatcag gcccagatgg tgccagaagt cctcacggat gttccagtgc
    36661 acacccaggg acgggtcgcc gcgcagctcg acgccgacgc actggcgacc gtgagccacc
    36721 gaccacagca acgacatcat gctggtcgcg ccaagcccga gggcgacgaa gtcggggttc
    36781 tgaatccccg tccagtcgac ctccaccttt gtgccgcgcg gtacccggga ctgcttcgtc
    36841 gggtcaagca ccgctggcgc actgctgcgc gacgcacgct tgaccaggga agctaatcga
    36901 aggttcttca tgacctttcc tcaactcttg agagtgacgg ataatgccag gcagtcgacc
    36961 gccgaatacg gcgagaatgg tcgccattcg actagatcaa tgctagctaa actgtcaagc
    37021 gggttgccgc tgaccagatc ccagattcgg gtgcattcac ggaggcctga accaacagtc
    37081 gcgggtccgc gcgcgcgtgg cgcggtaggt gcgagtggcg tggccgaccc cggccgcgtg
    37141 cacgtcaacg gccagcttgc tcgccgctgg ccgatcgcat cgctgccggt ctatcgcatc
    37201 gccacccaac atacgaggca acacctggca ccgactttaa cagcgggatc gtagaccgtc
    37261 cacatgggcg agtgacggac gaccgaggcg gtccggaatt ggccacttgc ccggtcagtc
    37321 acgtggacgc gtcggacact tcccttattt ccgacggctc tggcatcatg cagcagcgga
    37381 atcacttatg gtgacaaccc gcgagcaaga cgttgccgcg gctcccatcg ggaggctcta
    37441 tccgctggtt cgggctccgg aacgaccggc gcgggcggat tactccgtgg tgcccgcgct
    37501 cccctgctgc gccgccaggc gcacctgctc gtacacccag ttgcggggta gcccggtcac
    37561 ctcccggacc acctcccgga cgagccgggg ctcgacgccg tgccgcacca aggtctcggt
    37621 gagtcggtgg gccagcgcct cgtcctcgtc cgcaggctcc ccgggggcgc cggcgacgac
    37681 caccgtgaac tgccctcgga ccaccgcctc cgcgtcgagc ccggcgatca ggtcggaaag
    37741 tggaccccgg aggaactcct cgtcgtcctt ggtgaggttc cgggccagcg ccgccggtcg
    37801 gtcgccgagc accgcccgga cgtcctcgag catcgccacg atccggtggg gtgcctcgaa
    37861 gaagaccagg gtggccacgg tcgaccgcag cgcggtcaac gcgctccgcc gcgccgcctc
    37921 cctccgaggc aggaacccga cgtagtggaa ctggtggttc ggtaggccgg aaccgatcag
    37981 cgcggtcacc gaggcggtcg cgccgggcag cgggcggacc ggcacgtcgg cctcgacggc
    38041 cgccgccacc agccggtagc ccgggtcgtt gaccagcggc gtccccgcgt cggagacaag
    38101 cgcgacgtcc gtgccgtcgc ggagcatccc cagcagatgc tgactgcgcg actcctcgtt
    38161 gtggtcgtgg tagctcagca ggcgggtgtc gatctcgagg gactgcagca ggcggcgggt
    38221 gtgccgggtg tcctcggagg cgacgacgcc gacccggccg aggacctcga tcgcccggag
    38281 ggtgatgtca ccgggattgc cgatgggggt gggcaccagg tagagggtgc cgggatcggc
    38341 agcccccgac cgtcgcgttc cgtccgcctc tgccacccgt cgccccccgg tgtcgtctcg
    38401 gccaactcta tcgccagcac cccgcccccc accgccaccc cgccggccac ggccgtttcc
    38461 gggccgcaaa atcatcggac gggcacaccc aacccattcc ggctactcaa tgtcaccaat
    38521 gcaatacttg acaccctatc ggcgcataac taagatcgaa ctccgtcggg gcagaccaat
    38581 accgcccaga caaaaccgcg cccggcattt tccccgaaac ggatcccgtc ttgcttccgc
    38641 cgcaatcgcg cgaaagggcg acgaatgcct gacccggatc acccgaaaat aacggacatc
    38701 gtcgtttcgc cgcatttcga cgacggcgcc ctctcggtcg cttcggtgct gcgcagggga
    38761 cggcccgtgc ttctggtcac catctgtggt ggaccgccga ccgaaaatgg cgacgacgag
    38821 tgggaccgcc tctgcggttt cgagtccggc cccgccgccg ctgtgggacg tgccgcagag
    38881 gaccgtgccg ccgccgcgct cgccggcaac cgggtgaccc acctgcccgt cccggacgcg
    38941 ccgtaccgga ccgacttccc gtccgcggcg gtggtcgcgg cgctggcccc gctcttccgg
    39001 cccgacgtac gggtctgggc tccactgggg atcggcagcc acccggacca cgtcggcacc
    39061 cgggacgcgg tgctggccgc agccgccgga acgggctgcg ccgtcacctt ctacgccgac
    39121 tgcccgtacg cgttcggctc cggctgggac gccgccgacg gggaccggcc cgccaccgac
    39181 cggtgggagc cgcacctcac cgccctggcc cacctcgtcg acgcgaccag tcctcgggtc
    39241 acccgtctgg acgactccac gatgcggttg aagatcgcta tgcttcgctg tcacgcctcg
    39301 caactggccg gtctctccgt ggaccatccc cacttcatgg cctgggaggg accgttgcgc
    39361 caggaggtct tctggccggt gtccgccctg atccccggcc tggaaccaac tctcgggagt
    39421 agcgcatgat cgtcggaggc tcgaccatcc agccggagcg cgtcgacgcg gcggcacttc
    39481 gacagctcgg cgacgccctg cggaaggtgg tcggccgagc cgagccgacc cccctcgccg
    39541 acctgctctc cggcaccccg gtcgacccgg acgcgctgac cggggagatc ggcgtggagg
    39601 gccggcgggt gctgctcgac agcggcatgg ccgtcgacga cggcgccacc ttctcctcgc
    39661 cgctgcgcgg ccaccagatg cacggcgtgg tggtgctcag cgacccggac gtcgaggagg
    39721 atgtgcagca ccggtggtac gtcgacccgc tctgggaggc ggacctgctg atccggctga
    39781 tgctccggcg tggcggcgcg cgcgccctgg acatggggtg cggctccggg gtgctctccc
    39841 tggtgctcgc cgaccggtac gaatcggtcc tcggggtgga cgtcaacccg cgcgcggtgg
    39901 cgttgtcccg cctcaacgcc gccctcaacg gcctgacgaa cgtcaccttc cgcgagggcg
    39961 acatgttcga gccggccgag gggcggttct cgcggatcgt cttcaactcg ccgacgaacg
    40021 aggagggcag cgagttcgtc gacctgctcg aagccggtga gccgatcctg gagacgttct
    40081 tccgcgacgt gccccggaag ctggagtccg gtggcgtggt cgaggtcaac ctcgccatga
    40141 acgactaccc gggcaccccc ttccgggacc ggctcggcga ctggctcggg ctgaccgaga
    40201 acgggctgcg ggtgcacatc ttcacctcgc agcggcgcgc cacgggcgac gggggcgagt
    40261 ggaagcgggg ctggctggtg atcgcgcccg gcccggtggg gctcaccgag accgactggc
    40321 cctaccacgg ccggtacgag gaggacccgg actcgctgct cggcgcgacg gagcagcaac
    40381 tcgcctgagg agggcacccc gacgaggtgc gctggtcggt cgacacccga ccgcaccggc
    40441 ggtgccgacc gtcagtggcg gaccggggcc gccgtggccc cggtccgcca ctggtcagga
    40501 ggcgagcagt tcgtcgatct ggttgatcgc ccccgaggca ccctccacca cgcccatgtc
    40561 cagcacctgc tgcagggcct cggccgaggc gtaggtggag acgtaggtcg cgcgcgtgcc
    40621 gccgtcgtgc tcggtgaagg tgtagacgtt cccggagacc ggcaggtccg ggttcgggtt
    40681 gaagtccagg tcggcgaagc cgtcgtcgaa ggagaagccc cgaggctcct ccacgctctt
    40741 gaccagccag tatccggcgt gcttgtcgcc ctccggaccg gtcatgtagt acgtcacccg
    40801 accaccgggc gtgaggtcgt ggtcgaccac cgtcgccggg taggtcggcg gcccccacac
    40861 cttctccagc tggcgggggt cggcgtagac ctgccagacc cgctccacgg gggcggcgaa
    40921 gtccgcggtg atggtcaggg tcaggttgtc gagatcgtgc cggacgtcgg tcacgggcat
    40981 gggtcagtcc tcctggtcga aatcggctgc gatgagtgcg tcgatgcggg cgatgcggcc
    41041 acgccagacc tgttcgagtt cggtgagcat ggacgccacc gaccgcaccg ccgccacgtc
    41101 gccgctggcc agctgctcgc gaccgctgcg tcgcttggtc agcagaccgg ccttctcgag
    41161 cacggccacg tgcttctgca ccgcggcgaa gctcatgtcg tacttcgccg cgagcgcggt
    41221 gacggagtgc tccccggcca gcacgcgacg caggatgtca cgtcgggtgc ggtcggcgag
    41281 cgcctggaac atggcgtccg cccggtcctc gctctcgtcg gtcaccaccc caatatacaa
    41341 ccacttggtt gtgcgttgtc aagggtcacg tctccggcgc tgtcctgacg atggcagcgg
    41401 tccgccgcac cggggtttcc tcctggagaa cgatcggcgc ggcggggcga cgtgcgccgg
    41461 ccacgcgggc ccacgtacga gaacgggccc cgctcgccga gggagcgggg cccgcgtcga
    41521 ccggcgtggc tcgtcgccac accggcccgg tcagcgtcgg tcagtcgtcg tcgcggtcgt
    41581 catcgtcatc gtcgtcgcgg tcgtcatcgt cgtcgttccg gtcgtcatcg tcgtcgaccg
    41641 gctcctgctc ggccttgacc acgctgccgt tggtccggtc cacgtcgatc tcgtgctccg
    41701 tcccccccgt tcacgacctc gacgctccac acctgacggc cgtgctcctc ctccgcctcg
    41761 acctccacga tccggccgcc ctccggcgcg ggccaacgcg atctccccgg cgcgcttctc
    41821 gtccaccgcg ttcccggtcg ccggggtggt ggtgccaccg gacggtgtgg tgggcacacc
    41881 ggtcgccgcc ggggcggtgg gggtggcggg ggtgccgctc ggggtggcgg gggcagtcgg
    41941 ggccgtggtc gccgcggtca gggtggtacg accgctccgc ccgtcggcgg cggcagcggt
    42001 gccgatcacc gctccggcca ccgccagcac cgccgcaccc cccagggtgc ccatgatcag
    42061 ggacttgcgc ttcatctcga tgcaccttcc tcgggttctg cctacgagga tcggccggac
    42121 cgggatagcg gggcgctgta ccgacgctaa ggcccggtta aggctccggc cggggtcagg
    42181 tgcccgacgg agccgctggt ggcgcgagcc ggagcaacac ctcggctcca ccggtccggc
    42241 cgctccgcac ctccagtcgc ccgcccccga cctcggcggc ccggcgggcg atgtccagtc
    42301 cgagaccggt cgagccggcc gtgctggctc cccggcggac cgtgtccggc ggcatgcccg
    42361 gcccctcgtc ggccaccgtg agcagcatct ccccggacgc cccggagcgc ttcgcgcccg
    42421 taggggcgag ccgcacggtg aacggggtgc cgtccggggt gtgcgcgaac acgttgccga
    42481 gcagcgcgtc gaccgccgcg gccaggtcct cggcgggcac cgcgaccggc aacggcccgg
    42541 acgccagctc gcggtggacc gtccggccgg tgtcctcggc cagcaccgac cagaactgca
    42601 cccggtcggc gaccaccgcc gccgcgtcgc accccaccgg gccgaccgcc ggccgctgcc
    42661 gccgggcctg gcggatcagg ccggtcaccg cccgctccag cccgtcgacg gcactggtga
    42721 tccgggccgc gtcctgcggg tcgcccagcg actcggcctc cagccgcaac gcggtcagcg
    42781 gggtccggag ccggtgcgac aggtcggcca cctgctcgcg ttcctggccg agcagctcct
    42841 ggatgcggcc ggccaggtgg ttgagggcac cggccacctc gcgcagctcg gtcggaccgg
    42901 cgagggtcac ccgggcgtcg agatcagcgt tggcgagccg gtgcgacacg gcggagagtt
    42961 cgctgatcgg tcggaccagg gtgtgggcca gccggtcggc caccaccaga ctgatcacca
    43021 ccagcaaccc gccgagcagg gccaggacca gccaggcacg gcccaccccg gcggtcagct
    43081 ccgcgcccgg caccaccgtc cggatcacgc cggtgccgtc cggccggccc tgcaccgcga
    43141 tcaccacctc gcgtccctcc gccgactccg cggtgaggct ctggccgcgc gccgccaggg
    43201 ccaccgccgg ggtacggggt gccggcgtgc cgagcaccgt gccgtcgggc aggaagacgc
    43261 tgaccggtcg gccggactcg acggcgagcc gctcgacggt cagccggatc gtcgccgggt
    43321 cggcggtgcc caccaccggc accaggctct gcgcgtcggc ggtcgcccgg acggtggccc
    43381 ggtcctcggc gacggtgcgg accagcaacg cgagcggcac caggaaggcg accagggtga
    43441 gcacgctgac cgcggcggcc agcagggcca ggcgcgccct cacccggcct cctcaggagg
    43501 ggccagccgt acccccaccc ctcggacggt gtgcaggtag cggggctgct gggcgttctc
    43561 ccccagcttc cggcgcagcc acgacaggtg cacgtcgacg gtcttgtccg caccgccgta
    43621 cgggatctgc cagacctcgg tcatcagctc gcgcttggtg accacctcgc cggggcgggc
    43681 ggccagatgg tgcagcaggt cgaactcgcg cggggtcagc tcgaccggct caccgtccag
    43741 ggtcacctgg cgggcacgcg ggtcgacccg cagcccgccc acgaccagcg ccgggtcgtc
    43801 cgccccggcg gccgagccgc cgcggcgcag caccgcccgg acccgagcgt cgagctgggc
    43861 ggcggtgaac ggcttcacca cgtagtcgtc cgcacccgcg tcgaggaccc ggacgatctc
    43921 ggtctcgtcg tcacgggcgg tggccacgat caccggcacc gggctgaccg cgcgcagcat
    43981 ccgcagcagt tcccgaccgt cgaggtcggg caggccgagg tcgagcacga ccaggtcggg
    44041 ccggttctcc agcgcgtcgc gcagcccgtc catcgccgtc gacgcggccg ccaccgcgtg
    44101 cccccggtcc cgcagcgccc ggaccagcgg ggtccggatg gtcagatcgt cctcgatcag
    44161 cagcaggcgg ggcacacctg gcaggctaat cccctcccac cggcgccggc ccggtcgtta
    44221 accctccctt atcgtcgtcc ggtgcttccg ccaaccttcg atcggggata gtcggggcat
    44281 gcgccgtccg ttcctcgccg tcgccggctg gttggtcacc gccgtgctgc tcaccctggt
    44341 cggggtggcc gcgatccgcc tggttgggga gagcatcacc ggcaccccgg gcggcgtgcg
    44401 cagtcaggag gaggtcgagc gggcgctggc cgcgccggag ccgtcggcag cttccgccac
    44461 ccccggtgcg ccgccgccga ccgcatccgc gcggtcgggc gtaccgcggg tcttcgcgac
    44521 caccgggggc agcgcggtgg ccgagtgcgg gccggacggc gtacggctgg tctcctgggc
    44581 gccggcgcag gactaccggg tgggcgcggc cgaccggggc ccggacgacg acgtcgaggt
    44641 gagcttcgtc gggccgtccg gtgagcacga actgaagctg cgttgcgtcg gcggcgaacc
    44701 ggtggccgag cccgacgact gaggttccgc ccgtggtctc ggcgcaggct gacccaccgg
    44761 tccggacggc gtacccgctg gcgctgccgc gcagttgcac cggtccggca ccggtcaccg
    44821 gctgagcggg cacacccgcg ccggtcggcg gtgcagggct gatgcactga acagccccgc
    44881 gagggagacg gcagccggat ggcggacgac gccgtccggc tgccgtgcgg ctgagagcac
    44941 gtcccgcgac gacccgttca gggacacgcg gagtgtcagg cggcaccgcc gttgacgtac
    45001 agcacctggc cgttgatcca ccgcccggcc ggactggcga ggaaggccac cacgtcggcg
    45061 gtgtcggccg gttcgccgag ccggttcatc ggcgacatcg ccgccatccg ggcgacggcc
    45121 tgctcgtcct tgccgtcgag gaagagggcg gtggcggtgg ccccgggtgc gacggcgttc
    45181 acggtgatgt cgcgttcccc cagctcccgg gccaggatca gggtgatcgc gtccaccgcg
    45241 gccttgctgg cggcataggc ggagtaggtg ggcagggaca gtttgggcgt cgtactggag
    45301 atgttgatga tcgcgcctcc gggccggacc cggcgggccg cctgctggtc gaccacgaag
    45361 gtgccgcgga cgttcgtccg gtgcacccgg tccagatccg cgaggtccag ctcgacgatg
    45421 ggggcgtgga ccacgatccc ggccgagttc acgacgacgt cgattccgcc gtaggtctgc
    45481 tcggcggtgt cgaagagtct ggccaccgcg aactcgtcgg cgacgtcggc ctgcaccgcg
    45541 acggcgtccc caccggcggc ggcgatctcg gccacggtct gctccgcctc gaccttgctg
    45601 gtggcgtagt tcagcaccac cgcgtagccg tccgcggcca accgtttcac gatctggcga
    45661 ccgatgccct gggatccacc ggtgacgatc gcgacacgct gcgggacggt catgactggc
    45721 tctcctgatc ctgaggggcc cgtcgcggcg aaggcgctcc ggacaccgga ttagatcaaa
    45781 cagagacgtc ggcgggtagc cgttcccggc tgccgcttcg actcctgccg gagcccgacg
    45841 cggtggtcac cgaccaccgg ggacggaggc cggttccacc tgtccctccc tcggtcagcg
    45901 gtgggcgcgg ccaacggggc tgtcggcgaa ggcgaggccg tgctcggcca gcgcggcatc
    45961 caggatggcg accgccttcg gcccgacccc gtgcagggcc agcaggtcgc ggcggcgcca
    46021 ggtggccacc tgggccagcg tcgtgacgcc ggccgcgagc agggcgccgt tggcgggccg
    46081 tccgatcggg ggcagatcgc cgatctgcgc cggcaggtgg cgggtactca cgcgatcacc
    46141 ctagcccggc ggtatgtcgg gaaccactgg cacaaccaat ggtccggttc atccaccacg
    46201 agccggagga cggcagcgag tggccgaccg acccggcacc tggcggcgtg ccgctgaccc
    46261 gggccgtcgc tgcgatcacc gccaccggct accagatcga cccgccgctg tggcgttcga
    46321 aggcggactg cacgcagtgc cacgccggct gccacgacag cccgacacgc tgacccgctc
    46381 cgctcccgca ccaccgcctg ctgcgacggc cgtaggctca acgaagacca acggccgccg
    46441 cagtcagcat gaggagcagg catgcccaag caccactggg aagacctgcc catccccgtc
    46501 cggcacgcca tccaggcaca caccggcccc gtcagaaccg cacgatcagc cgtgacaggt
    46561 tccgtctccg acatcgccac gaccctggac accgagaccg gatccgtctt ccgcaaggcc
    46621 atccgcgcca gcaacccgat ggcccggatg caccgcacgg aggcccgcgt caacccgtgg
    46681 ctgcccgacg ttgcaccccg cctgcgttgg accgtcgagg aagccggctg gctggtcctc
    46741 ggcttcgacc acgtgtccgg tcgccatccc gacctgtccc ccggctcgac agacctaccg
    46801 gccatcgccg acaccctcac cgtgctgtcg caccaactga ctccgtgccc gcccgtcaag
    46861 gtgcaggcag ccactacgcg atgggaaggc cgactcgccc ccgacttggt cgacggagac
    46921 accctcgtcc acaccgacgt caccccgttc aacttcctac tcggcacaca cgtccacgt
//
