BGC0000722: validamycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. jinggangensis
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Location: 1 - 45,164 nt. (total: 45,164 nt).
This entry is originally from NCBI GenBank DQ164098.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000722
Short description validamycin A biosynthetic gene cluster from Streptomyces hygroscopicus subsp. jinggangensis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • other (cyclitol)
  • saccharide (None)
Loci
DQ164098.1
via Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production
Compounds
  • validamycin A
Species Streptomyces hygroscopicus subsp. jinggangensis [taxonomy]
References
Chemical products information
validamycin A Evidence: NMR
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C20H35N1O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ABA41524.1
 1395 - 2597 (-) integrase
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    • ABA41525.1
    		 2975 - 4150 (+) transposase
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      • ABA41500.1
      		 5054 - 5884 (-) transposase
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        • ABA41501.1
        • valO
        		 6051 - 6716 (-) phosphatase/phosphohexomutase
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          • ABA41502.1
          • valN
          		 7480 - 8475 (-) dehydrogenase
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            • ABA41503.1
            • valM
            		 8478 - 9752 (-) aminotransferase
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              • ABA41504.1
              • valL
              		 9776 - 11254 (-) trehalose-6-phosphate synthase
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                • ABA41505.1
                • valK
                		 11344 - 12318 (-) dTDP-4-dehydrorhamnose reductase
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                  • ABA41506.1
                  • valA
                  		 13630 - 14874 (+) 2-epi-5-epi-valiolone synthase
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                    • ABA41507.1
                    • valB
                    		 14879 - 16000 (+) glucose-1-phosphate adenylyltransferase
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                      • ABA41526.1
                      • valC
                      		 15997 - 17052 (+) glucokinase
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                        • ABA41508.1
                        • valD
                        		 17860 - 19215 (+) ValD
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                          • ABA41509.1
                          • valE
                          		 19643 - 20638 (+) oxidoreductase
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                            • ABA41510.1
                            • valF
                            		 21457 - 22662 (+) oxidoreductase
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                              • ABA41511.1
                              • valG
                              		 23045 - 24313 (+) glucosyltransferase
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                                • ABA41512.1
                                • valH
                                		 24446 - 25642 (+) transport protein
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                                  • ABA41513.1
                                  • valI
                                  		 26802 - 28637 (+) glycosyl hydrolase
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                                    • ABA41514.1
                                    • valJ
                                    		 29207 - 30124 (+) oxidoreductase
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                                      • ABA41515.1
                                      		 31746 - 32360 (+) unknown
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                                        • ABA41516.1
                                        		 33340 - 34383 (+) unknown
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                                          • ABA41517.1
                                          • valP
                                          		 35281 - 36162 (-) regulatory protein
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                                            • ABA41518.1
                                            • valQ
                                            		 36159 - 36764 (-) regulatory protein
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                                              • ABA41519.1
                                              		 38103 - 38678 (+) tellurium resistance protein
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                                                • ABA41520.1
                                                		 39292 - 40647 (+) unknown
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                                                  • ABA41521.1
                                                  		 41189 - 42061 (-) unknown
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                                                    • ABA41522.1
                                                    		 42207 - 43133 (-) esterase
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                                                      • ABA41523.1
                                                      		 43374 - 44423 (-) cytochrome P450 hydroxylase
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                                                        Biosynthesis information
                                                        Annotation changelog

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Corrected compound details
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Removed incorrect polyketide information
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: 67IIUGVPORSPZSAXSJ6T72RE)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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