BGC0000724: streptomycin biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
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Location: 6,919,728 - 6,951,001 nt. (total: 31,274 nt).
This entry is originally from NCBI GenBank AP009493.1.

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core biosynthetic genes
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transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000724
Short description streptomycin biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • saccharide (None)
Loci
AP009493.1
6919728 - 6951001
via
Compounds
  • streptomycin
Species Streptomyces griseus subsp. griseus NBRC 13350 [taxonomy]
References
Chemical products information
streptomycin Evidence:
Copy SMILES
C21H39N7O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SGR_5914
  • BAG22743.1
  • strU
 6919728 - 6921014 (-) putative NAD(P)-dependent oxidoreductase
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    • SGR_5915
    • BAG22744.1
    • strV
    		 6921491 - 6923245 (+) putative ABC-type multidrug transport system ATPase and permease component
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      • SGR_5916
      • BAG22745.1
      • strW
      		 6923242 - 6924984 (+) putative ABC-type multidrug transport system ATPase and permease component
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        • SGR_5917
        • BAG22746.1
        • stsG
        		 6925055 - 6925816 (+) putative L-glutaminyl-2-N-methyltransferase
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          • SGR_5918
          • BAG22747.1
          • stsF
          		 6925880 - 6926569 (+) StsF protein
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            • SGR_5919
            • BAG22748.1
            • stsE
            		 6926566 - 6927558 (+) putative ATP:scyllo-inosamine phosphotransferase
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              • SGR_5920
              • BAG22749.1
              • stsD
              		 6927555 - 6928238 (+) putative aminosugar-converting enzyme
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                • SGR_5921
                • BAG22750.1
                • stsC
                		 6928245 - 6929519 (-) putative L-glutamine:scyllo-inosose aminotransferase
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                  • SGR_5922
                  • BAG22751.1
                  • stsB
                  		 6929758 - 6931281 (+) putative NADH:N-amidino-scyllo-inosamine oxidoreductase
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                    • SGR_5923
                    • BAG22752.1
                    • stsA
                    		 6931338 - 6932570 (+) putative L-alanine:N-amidino-3-keto-scyllo-inosamine aminotransferase
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                      • SGR_5924
                      • BAG22753.1
                      • strO
                      		 6932612 - 6933391 (-) putative glucose-1-phosphate thymidylyltransferase
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                        • SGR_5925
                        • BAG22754.1
                        • strN
                        		 6933524 - 6934447 (+) putative N-amidionostreptamine 6-phosphotransferase
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                          • SGR_5926
                          • BAG22755.1
                          • strB2
                          		 6934444 - 6935496 (+) putative scyllo-inosamine-4-phosphate amidinotransferase
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                            • SGR_5927
                            • BAG22756.1
                            • strM
                            		 6935539 - 6936141 (+) putative dTDP-4-dehydrorhamnose 3,5-epimerase
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                              • SGR_5928
                              • BAG22757.1
                              • strL
                              		 6936173 - 6937087 (-) putative dTDP-4-dehydrorhamnose reductase
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                                • SGR_5929
                                • BAG22758.1
                                • strE
                                		 6937144 - 6938133 (-) putative dTDP-glucose 4,6-dehydratase
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                                  • SGR_5930
                                  • BAG22759.1
                                  • strD
                                  		 6938220 - 6939287 (-) putative glucose-1-phosphate thymidylyltransferase
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                                    • SGR_5931
                                    • BAG22760.1
                                    • strR
                                    		 6939694 - 6940746 (+) streptomycin biosynthesis operon regulator
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                                      • SGR_5932
                                      • BAG22761.1
                                      • aphD
                                      		 6940981 - 6941904 (+) streptomycin 6-phosphotransferase
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                                        • SGR_5933
                                        • BAG22762.1
                                        • strB1
                                        		 6942395 - 6943441 (+) scyllo-inosamine-4-phosphate amidinotransferase
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                                          • SGR_5934
                                          • BAG22763.1
                                          • strF
                                          		 6943485 - 6944330 (+) StrF protein
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                                            • SGR_5935
                                            • BAG22764.1
                                            • strG
                                            		 6944340 - 6944939 (+) StrG protein
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                                              • SGR_5936
                                              • BAG22765.1
                                              • strH
                                              		 6945101 - 6946255 (+) putative dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase
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                                                • SGR_5937
                                                • BAG22766.1
                                                • strI
                                                		 6946300 - 6947346 (+) putative NAD:myo-inositol oxidoreductase
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                                                  • SGR_5938
                                                  • BAG22767.1
                                                  • strK
                                                  		 6947343 - 6948692 (+) putative streptomycin-6-phosphate phosphatase
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                                                    • SGR_5939
                                                    • BAG22768.1
                                                    • strS
                                                    		 6948805 - 6949941 (+) putative N-methyl-L-glucosamine biosynthetic aminotransferase
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                                                      • SGR_5940
                                                      • BAG22769.1
                                                      • strT
                                                      		 6950048 - 6951001 (+) putative oxidoreductase
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                                                        Biosynthesis information
                                                        Annotation changelog

                                                        Entry version: next

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2024-04-23
                                                        MIBiG v4 annotathon
                                                        • (ID: BRDSH5WICJIVUPRS7ELUSARQ)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 4

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-10-07
                                                        Update chemical activity to schema version 2.11
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 3

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2022-09-15
                                                        Updated bioactivity data
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 2

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2019-10-16
                                                        Migrated from v1.4
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                        Entry version: 1

                                                        Date
                                                        Changes
                                                        Submitters
                                                        Reviewers
                                                        2015-06-12
                                                        Submitted
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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