BGC0000724: streptomycin biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
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Location: 6,919,728 - 6,951,001 nt. (total: 31,274 nt).
This entry is originally from NCBI GenBank AP009493.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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TTA codons
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Gene details
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General
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Genes
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KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000724
Short description streptomycin biosynthetic gene cluster from Streptomyces griseus subsp. griseus NBRC 13350
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Saccharide
Loci NCBI GenBank: AP009493.1
Compounds
  • streptomycin
Species Streptomyces griseus subsp. griseus NBRC 13350 [taxonomy]
References
Chemical products information
streptomycin
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C21H39N7O12
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • SGR_5914
  • BAG22743.1
  • strU
 6919728 - 6921014 (-) putative NAD(P)-dependent oxidoreductase
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  • SGR_5915
  • BAG22744.1
  • strV
 6921491 - 6923245 (+) putative ABC-type multidrug transport system ATPase and permease component
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  • SGR_5916
  • BAG22745.1
  • strW
 6923242 - 6924984 (+) putative ABC-type multidrug transport system ATPase and permease component
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  • SGR_5917
  • BAG22746.1
  • stsG
 6925055 - 6925816 (+) putative L-glutaminyl-2-N-methyltransferase
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  • SGR_5918
  • BAG22747.1
  • stsF
 6925880 - 6926569 (+) StsF protein
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  • SGR_5919
  • BAG22748.1
  • stsE
 6926566 - 6927558 (+) putative ATP:scyllo-inosamine phosphotransferase
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  • SGR_5920
  • BAG22749.1
  • stsD
 6927555 - 6928238 (+) putative aminosugar-converting enzyme
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  • SGR_5921
  • BAG22750.1
  • stsC
 6928245 - 6929519 (-) putative L-glutamine:scyllo-inosose aminotransferase
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  • SGR_5922
  • BAG22751.1
  • stsB
 6929758 - 6931281 (+) putative NADH:N-amidino-scyllo-inosamine oxidoreductase
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  • SGR_5923
  • BAG22752.1
  • stsA
 6931338 - 6932570 (+) putative L-alanine:N-amidino-3-keto-scyllo-inosamine aminotransferase
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  • SGR_5924
  • BAG22753.1
  • strO
 6932612 - 6933391 (-) putative glucose-1-phosphate thymidylyltransferase
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  • SGR_5925
  • BAG22754.1
  • strN
 6933524 - 6934447 (+) putative N-amidionostreptamine 6-phosphotransferase
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  • SGR_5926
  • BAG22755.1
  • strB2
 6934444 - 6935496 (+) putative scyllo-inosamine-4-phosphate amidinotransferase
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  • SGR_5927
  • BAG22756.1
  • strM
 6935539 - 6936141 (+) putative dTDP-4-dehydrorhamnose 3,5-epimerase
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  • SGR_5928
  • BAG22757.1
  • strL
 6936173 - 6937087 (-) putative dTDP-4-dehydrorhamnose reductase
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  • SGR_5929
  • BAG22758.1
  • strE
 6937144 - 6938133 (-) putative dTDP-glucose 4,6-dehydratase
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  • SGR_5930
  • BAG22759.1
  • strD
 6938220 - 6939287 (-) putative glucose-1-phosphate thymidylyltransferase
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  • SGR_5931
  • BAG22760.1
  • strR
 6939694 - 6940746 (+) streptomycin biosynthesis operon regulator
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  • SGR_5932
  • BAG22761.1
  • aphD
 6940981 - 6941904 (+) streptomycin 6-phosphotransferase
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  • SGR_5933
  • BAG22762.1
  • strB1
 6942395 - 6943441 (+) scyllo-inosamine-4-phosphate amidinotransferase
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  • SGR_5934
  • BAG22763.1
  • strF
 6943485 - 6944330 (+) StrF protein
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  • SGR_5935
  • BAG22764.1
  • strG
 6944340 - 6944939 (+) StrG protein
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  • SGR_5936
  • BAG22765.1
  • strH
 6945101 - 6946255 (+) putative dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase
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  • SGR_5937
  • BAG22766.1
  • strI
 6946300 - 6947346 (+) putative NAD:myo-inositol oxidoreductase
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  • SGR_5938
  • BAG22767.1
  • strK
 6947343 - 6948692 (+) putative streptomycin-6-phosphate phosphatase
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  • SGR_5939
  • BAG22768.1
  • strS
 6948805 - 6949941 (+) putative N-methyl-L-glucosamine biosynthetic aminotransferase
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  • SGR_5940
  • BAG22769.1
  • strT
 6950048 - 6951001 (+) putative oxidoreductase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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