BGC0000727 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000727 (Streptomyces aureofaciens)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS-like	1	29,395	indigoidine	saccharide	100%

BGC0000727 - Region 1 - NRPS-like

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Location: 1 - 29,395 nt. (total: 29,395 nt) Show pHMM detection rules used

Region on contig edge.

NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,396
Label		BGC0000727

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000727	1.00	Saccharide	indigoidine	Streptomyces aureofaciens
BGC0001817	0.35	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000375	0.30	NRP	indigoidine	Streptomyces chromofuscus
BGC0000278	0.29	Polyketide	urdamycin	Streptomyces fradiae
BGC0001561	0.28	NRP	curacomycin	Streptomyces curacoi
BGC0000900	0.28	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.28	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348	0.27	NRP	ergovaline	Epichloe festucae var. lolii
BGC0002710	0.26	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000772	0.26	Saccharide	lipopolysaccharide	Brucella melitensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000727	1.00	Saccharide	indigoidine	Streptomyces aureofaciens
BGC0001817	0.68	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000375	0.63	NRP	indigoidine	Streptomyces chromofuscus
BGC0000278	0.62	Polyketide	urdamycin	Streptomyces fradiae
BGC0001561	0.62	NRP	curacomycin	Streptomyces curacoi
BGC0000900	0.62	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.61	NRP	dimethylcoprogen	Alternaria alternata
BGC0000348	0.61	NRP	ergovaline	Epichloe festucae var. lolii
BGC0002710	0.60	NRP	metachelin C, metachelin A, metachelin A-CE, metachelin B, dimerumic acid 11-mannoside, dimerumic acid	Metarhizium robertsii ARSEF 23
BGC0000772	0.59	Saccharide	lipopolysaccharide	Brucella melitensis

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29395:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Gln)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

sa8

Search NORINE for peptide: strict or relaxed

AMP-binding (23..431): Gln

nrpys: Gln

SVM prediction details:

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DAWQFGVINK
Nearest Stachelhaus code(s):: Gln DAWQFGLINK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)