LOCUS       BGC0000733             20914 bp    DNA     linear   BCT 26-SEP-2007
DEFINITION  Klebsiella pneumoniae capsular polysaccharides biosynthesis gene
            cluster, complete cds, strain: NTUH-KP35.
ACCESSION   BGC0000733
VERSION     BGC0000733
KEYWORDS    .
SOURCE      Klebsiella pneumoniae
  ORGANISM  Klebsiella pneumoniae
            Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:07:10
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20914
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..20914
                     /country="Taiwan"
                     /db_xref="taxon:573"
                     /isolation_source="isolated from a patient with pyogenic
                     liver abscess"
                     /mol_type="genomic DNA"
                     /organism="Klebsiella pneumoniae"
                     /serotype="K54"
                     /strain="NTUH-KP35"
     subregion       1..20914
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="saccharide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20914
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            152..1048
                     /gene="galF"
     CDS             152..1048
                     /codon_start=1
                     /gene="galF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 186.7; E-value:
                     9.1e-57)"
                     /gene_kind="biosynthetic-additional"
                     /product="UDP-glucose pyrophosphorylase"
                     /protein_id="BAF47056.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.3e-10, bitscore:
                     30.0, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMANLKAVIPVAGLGMHMLPATKAIPKEMLPIVDKPMIQYIVDE
                     IVAAGIKEIVLVTHSSKNAVENHFDTSYELEALLEQRVKRQLLAEVQAICPPGVTIMNV
                     RQAQPLGLGHSILCARPVVGDNPFVVVLPDIILDGGTADPLRYNLAAMIARFNETGRSQ
                     VLAKRMPGDLSEYSVIQTKEPMVAEGQVARIVEFIEKPDEPQTLDSDLMAVGRYVLSAD
                     IWTELERTEPGAWGRIQLTDAIAELAKKQSVDAMLMTGESYDCGKKIGYMQAFVTYGMR
                     NLKEGTKFRESIKKMLA"
     gene            1441..2070
                     /gene="acidPPc"
     CDS             1441..2070
                     /codon_start=1
                     /gene="acidPPc"
                     /product="acid phosphatase homologue"
                     /protein_id="BAF47057.1"
                     /transl_table=11
                     /translation="MNWQLISFFGDSTVLLPSAAALFIVLMLRKTSRLLAWQWSLLFGI
                     TGAIVCASKLAFMGWGLGIRELDFTGFSGHSALSAAFWPIFLWLLSARFSVGLRKAAVI
                     TGYVLAAVVGYSRLVIHAHSVSEVIAGLLLGAAGSALFLVLQKRTPDPENVNISWGGVA
                     CLVMVPLILLHSGSKAPTQSLLGQIATAVGPLDKPFTRTDLHKQAW"
     gene            3030..4469
                     /gene="wzi"
     CDS             3030..4469
                     /codon_start=1
                     /gene="wzi"
                     /product="surface assembly of capsule"
                     /protein_id="BAF47058.1"
                     /transl_table=11
                     /translation="MIKIARIAVTLGLLSSLGAQAYAAGLVVNDNDLRNDLAWLSDRGV
                     IHLSLSTWPLSQEEIARALKKAKPSYSSEQVVLARINQRLSALKADFRVTGYTSTDQPG
                     TPQGFGQTQPADNSLGLAFNNSGEWWDIHLQGNVEGGERISNGSRFNANGAYGAVKFWN
                     QWLSFGQVPQWWGPGYEGSLIRGDAMRPMTGFLMQRAEQAAPETWWLRWVGPWQYQISA
                     SQMNQYAVIPHTKIIGGRFTFSPFQSLELGASRIMQWGGEGRPESFSSFWNGLTGKDNT
                     SANDPNEPGNQLAGFDFKYKLEPTLGWPISFYGQLIGEDEAGFLPSANMYLGGIEGHHG
                     WGKNALNWYLEAHDTRTNMSRTGYSYWHHLYTDGYYQQGYSLGDAMGGDGQLLAGKVEL
                     ITEDNQRWSSRLVYAKVNPENQPINKAFPHADTLKGVQLGWSGDVYQSVRLNTSLWYTN
                     ANNSDSDDIGASAGIEIPFSL"
     gene            4615..5748
                     /gene="wza"
     CDS             4615..5748
                     /codon_start=1
                     /gene="wza"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 278.1;
                     E-value: 1.4e-84)"
                     /gene_kind="transport"
                     /product="multimeric putative translocation channel"
                     /protein_id="BAF47059.1"
                     /sec_met_domain="Poly_export (E-value: 2.8e-32, bitscore:
                     100.8, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKKIVRFSALALAIGFLSGCTIIPGQGLNSLRKNVVELPDSDYD
                     LDKLVNVYPMTPGLIDQLRPETVLARPNPQLDNLLRSYEYRIGVGDVLMVTVWDHPELT
                     TPAGQYRSASDTGNWVNSDGTIFYPYIGKVQVAGKTLAQVRQDIASRLTTYIESPQVDV
                     SIAAFRSQKAYVTGEVTKSGQQPITNIPLTVMDAINAAGGLAPDADWRNVILTHDGKDT
                     KISLYALMQKGDLSQNHLLYPGDILFVPRNDDLKVFVMGEVGKQSTLKMDRSGMTLAEA
                     IGNAEGISQEFSDATGIFVVRQLKGDKQGKIANVYQLNAQDASAMVLSTEFQLQPYDIV
                     YVTTAPLVRWNRVISQLVPTITGVHDMTETGKYIRTW"
     gene            5754..6188
                     /gene="wzb"
     CDS             5754..6188
                     /codon_start=1
                     /gene="wzb"
                     /product="protein tyrosine phosphatase"
                     /protein_id="BAF47060.1"
                     /transl_table=11
                     /translation="MFNSILVICTGNICRSPFAERILRKKLPNMKIDSAGTGALVDSAA
                     DSTAMRIAKSFDVSLDGHKGKQFSAKLGREYDLILVMEKAHITQISSIAPEVRGKTMLL
                     NHWVNQKDIPDPYRKSDEAFESVFNLIEKACLKWVEKLNG"
     gene            6207..8357
                     /gene="wzc"
     CDS             6207..8357
                     /codon_start=1
                     /function="high-level polymerization of capsular
                     polysaccharide"
                     /gene="wzc"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1216:exopolysaccharide biosynthesis domain protein
                     (Score: 361.8; E-value: 1e-109)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative transmembrane protein"
                     /protein_id="BAF47061.1"
                     /transl_table=11
                     /translation="MSSTKSNKRISADEIDIGRLYGELIDHRKLILSITAISVFISILY
                     CLFATPVYQADALIQVEQKQGNTILESLSQVLPDAQPQSAPEISLLQSRMILGKTVDDL
                     KLQTIVTNNYFPIVGKGWARLIGENSGNIDVENMIIPEQKLKENNKAILTVINNNEYTV
                     SIDDTTYHGKVGVQIKEPNLSLLINKIDAQPGDSFKIKYKTRLEAINDLANSFHVEDQG
                     KDTGMLALTLTGDDPSLISVILNKISENYLEQNVSRQAAQDARSLEFLNERLPKVRDDL
                     DRAEDKLNSYRKQKDSVDLSLEAKATLDQLVNVDNQINELTFREAEISQLFTKDHPTYK
                     ALIEKKNTLSKERGLLNNRISAMPATQQEVLRLSRDVESGRTVYMMLLNRQQELEISKS
                     SAIGNVRIVDESVTEPEPVKPKKAMVVILGVLLGGLISVGVVLLRVSFRRGIESPEQLE
                     EVGISVYSSIPVSEWLESNNKTRHGDSWNLLAIDNPADLAIEAIRGLRTSLHFAMLEAK
                     NNILMISGASPNAGKTFVSSNLAVIEAQTGKSVLFIDADMRKGYSHKLFGINIGNDNVG
                     LSELLSSNYDFEKAINKIAEMKIDFISRGQVPHNPAEMLTSIKFDNLLRWAASNYDLVI
                     VDTPPVLAVTDAEIIGRYVGTTLLVARYETNTVKEMEVSIKRFERSGINVKGCILNGVM
                     KKSSSYYGYGYNHYGYTYNDDK"
     CDS             8410..9570
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 113.7;
                     E-value: 2e-34)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf7"
                     /product="putative glycosyltransferase"
                     /protein_id="BAF47062.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 2.7e-32,
                     bitscore: 101.9, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKILRVIPSMDPQKGGPSEGIKQLQQEIHRQGLNIKCDIVCMDD
                     LSKDVKDVEYASIYAVGKGKGVYSYSESLKDWLEKNVQKYDFVIIHGIWQYHSYIASKL
                     CIKNSIPYFLYTHGMLDPWFKKNYPIKHIKKMIYWMLIERKVVNNAEAVIFTSEEEKIL
                     ARQSFPLYEPKEFVTAYGTSGSIVDKEIARSAFNEKFPSLKGKKILLYMGRIHEKKGCD
                     ILINSYAKISKEHNDYHLFIAGPDTSAYAKTLKDLVSSLNLNDKVTWGGMLSGDVKWGA
                     YYSSEIFCLASHQENFGIVVAEALSCEVPVVTTTKVNIWREIERADAGMIAIDNDDSFT
                     ECLNEFIKKYENDRERLRGNALRCFKENFDIKLVATSFNNLISSER"
     gene            9655..10821
                     /gene="wzx"
     CDS             9655..10821
                     /codon_start=1
                     /gene="wzx"
                     /product="flippase"
                     /protein_id="BAF47063.1"
                     /transl_table=11
                     /translation="MFIAQTLLISKSEVALVGQITIGLGLLTLAQWLADAGGVFLIPRL
                     LGSEENAQKRLACFINARFIFVTIIVISVLVYLITKNSWHLYYGLVSFIIPVLLISSFS
                     VIGYLDFYNETKASGTLSGVSWSLASLPLYYSYFYEGDRYIIGMSAGLLFVLGNALFII
                     IQCVKMKQVSKNGGIKLMYKDGFCIKKIKYSFYDIIKYNLNYGFSQSYGRFVPILLNTL
                     LGPVLAGYYIYAKSFANIANQFIAFSRRVEFSNLIAIHNGSVRKILSSQLISFGIACIF
                     AIFCFGTELIECFYTLPIGNNTLLYIQIIALINLLWCLSSSFSQYFIAKGKLGFICITQ
                     LITYILSLSIIYFGVEYLSIYSVFAAESIMYIVQFLIFIVFLKTYKKL"
     gene            10918..12000
                     /gene="wzy_K54"
     CDS             10918..12000
                     /codon_start=1
                     /gene="wzy_K54"
                     /note="allele of magA"
                     /product="serotype K54 polymerase"
                     /protein_id="BAF47064.1"
                     /transl_table=11
                     /translation="MVKVAILLFIMQLNSMLAVGLGWLPQSVALSVRVCVGGYLLYHYI
                     RNGKMHYSLYVLLLVMLTLFIINNMILIINFIFVSLMIYSIKDNGEESIIKSIYYSTIA
                     LSLIFIVISLNGILHPTILYSPDTGRYRNSLGFISPNYPGLIAFSCIVALFSCLGMLKS
                     KVGKKSKILVVIIALFCLVIPLLTDSRTPLYTLIVSFIFYVFLRFSFFRLLTRIFIPLV
                     PAIFMGLTLYIAFYYNHDINALLSGRPYLYSLYLKDFGWADYLLGGEGTQGFSVDSSYL
                     LLLSCFGVFSFLIIAFLLYKCLVNNKNKYVYAMFFSIFVYGLSESIMVRPEISVVFLFY
                     SLLAIKSDKIMNHDELNCHT"
     CDS             12142..12576
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 55.5;
                     E-value: 9.2e-17)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf10"
                     /product="putative acetyltransferase"
                     /protein_id="BAF47065.1"
                     /transl_table=11
                     /translation="MFRYRNFILSLFGARLGNNVRIYPSAKIWIPRNLTIGNNSSIGPR
                     AQIYNQGSIYIGNDSIISQDVTICASTHDYNKRDHPLILKNVEIGNRVWLCAESFVGPG
                     VQVFDGAVLGARAVAKRNLSSWSVYDGNPCNKLKERMNNE"
     CDS             12569..13489
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="orf11"
                     /product="putative glycosyltransferase"
                     /protein_id="BAF47066.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 7.1e-17,
                     bitscore: 52.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKPNLTVIILTKNEQLHLRRCLDSVINFCERIVIVDSFSDDNTL
                     EIIKEYPGIVELYQHKFINHANQFQWGLDNSGVTTDWVMRLDADEYIESELQAEIQNKL
                     NLIDKNKNCIFIRRKYFYKGKWIKHGAVYPLNLLRIWRNGQGRIEQRWMDEHIVVNNPQ
                     PEFFKGHIVDYNLNDMKWWIEKHIKYADREVVDLLNIKYQLFNRDEDVRKQGGFQARLK
                     RKVKEDLYFKLSPSLRSLLYFLYRYFFRLGFLDGSKGWDFHLMQGLWYRSYVDIRYKEL
                     DALISDISSDREKLSVLSKSTGLSL"
     CDS             13500..14618
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     282.1; E-value: 1e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf12"
                     /product="GDP-D-mannose dehydratase"
                     /protein_id="BAF47067.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 7.7e-12, bitscore:
                     35.0, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVALITGVTGQDGSYLAEFLLEKGYEVHGIKRRSSSFNTDRVD
                     HIYQDPHSSNPKFHLHYGDLTDTSNLTRLLSEIKPDEVYNLGAMSHVAVSFESPEYTAD
                     VDAIGTLRLLEAIRFLGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLY
                     AYWITVNYRESYGMYACNGILFNHESPRRGETFVTRKITRGLSNIAQGLEKCLYLGNMD
                     SLRDWGHAKDYVKMQWLMLQQEQPEDYVIATGVQYSVRQFVDFAASELGIKLRFEGHGV
                     DEVGIVESVSGEDAPAVKVGDVIVAVDPRYFRPAEVETLLGDPSKAHDKLGWKPETTLQ
                     EMVVEMVRKDLEAAKKHSLLKSHGYEVSISLE"
     CDS             14622..15590
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     204.8; E-value: 3.4e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf13"
                     /product="GDP-fucose synthetase"
                     /protein_id="BAF47068.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.8e-09, bitscore:
                     26.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIKKRVFVAGHKGMVGSAIVRQLKNRDDIELVLRSRQELNLLNA
                     QDVNNFFANERIDEVYLAAAKVGGIVANNTYPADFIYENILIEANIIHAAHVNDVYKLM
                     FLGSSCIYPKYAKQPISESELLQGTLESTNEPYAIAKIAGIKLCESYNRQYNRDYRSVM
                     PTNLYGENDNFHPSNSHVIPALLRRFHEAKLEGLPQVVVWGSGTPMREFLHVDDMAAAS
                     IYVMELDKALWQEQTQPMLSHINVGTGVDCSIKELAETISKVVGYQGEVVFDSTKPDGT
                     PRKLLDVSRLVGLGWKYQINLEAGLARTYEWFLRNQQSFRS"
     CDS             15592..16050
                     /codon_start=1
                     /note="orf14"
                     /product="putative GDP-mannose"
                     /protein_id="BAF47069.1"
                     /transl_table=11
                     /translation="MFLDDNTFKNVIRNTPLISIDLIIQNEKGEYLVGKRNNRPARGFW
                     FVPGGRIQKDESLDNGFARLTQNEIGIKMIRNESTFLGVFQHFYDDNFFNTEFSTHYIV
                     LAYEISIISSGLVFPHEQHNEYHWMRVDEILNNDLVHFNTKAYFMDVA"
     CDS             16062..17276
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /note="orf15"
                     /product="putative glycosyl transferase"
                     /protein_id="BAF47070.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 8.8e-16,
                     bitscore: 48.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLLVYGINYRPELTGIGKYSGEMVKWFVDNGLDVRVITAPPYYP
                     AWKVASDYSGWKYTKEKHPQIVYRCPLYVPNKPSTIKRLLHLSSFAFSSFFPLVMQARW
                     KPDYIICVVPTLFYVPGALLLRKLTRAKVIIHIQDFEVDAMLGLGMAKKGVFATFAKKF
                     EKWCLTSADKVSSISKTMLLNASDKGVPQSNLIFFPNWSELERFKNVKSEQSVKLKEEF
                     GIAEEQKVILYSGNIGEKQGLEIVISAAQKMTANNYVFLFVGQGGGKEKLERMSAELDL
                     KNVLFKPLQPYELLPALLNIADCHLVVQKKGAADAVLPSKLTNILAIGGNSVITAEEST
                     ELGQLCKNNPGIAQCVEPESVDALISGIEKCLLMPRHNDVAIKYANASLDMNNVLSKFI
                     VDIKR"
     CDS             17579..18982
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 351.4; E-value:
                     1.3e-106)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf16"
                     /product="putative CPS biosynthesis glycosyltransferase"
                     /protein_id="BAF47071.1"
                     /sec_met_domain="Bac_transf (E-value: 2.1e-75, bitscore:
                     242.3, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATLYHRTRSNANASLISMAQRFSDVVIIFLGLYLVCLINSVPFE
                     YQHALMSLLSLVIFQMIGGITDFYRSWRGVAFSTEYILIFKNWTLSLLIALGLLSLDSS
                     IDTRFLFFIQWYLLVDVGFFVCRSVIRLISGLLRKFGYNTRRVAVVGSLPAGINLLKSF
                     IEQPWLGFVVKGIYDNIKLDSAEYDNVPYAGNIDKLIQEAREGKIDRIYIAMSMRDESK
                     IKDVVRQLTDTTCSVLLIPDIFTFNILQSRTEEINGVPVVPLFDSPLNGINMVFKRLED
                     IIVSSLILILISPILLVIATAVKTTSKGPVIFRQVRYGMDGKPIKVWKFRSMTVMENDD
                     KVIQATKNDIRVTKVGKFLRSTSLDELPQFFNVLFGQMSVVGPRPHAVSHNEQYRSLIQ
                     GYMLRHKVKPGITGLAQINGWRGETDTLEKMEKRIEYDLLYIRGWSIWLDLKIIFLTVF
                     KGFINKSAY"
     gene            19146..20552
                     /gene="gnd"
     CDS             19146..20552
                     /codon_start=1
                     /gene="gnd"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100:3-hydroxyisobutyrate dehydrogenase (Score: 14.1;
                     E-value: 0.00041)"
                     /gene_kind="biosynthetic-additional"
                     /product="6-phosphogluconate dehydrogenase"
                     /protein_id="BAF47072.1"
                     /transl_table=11
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSVFNRSREKTEEVIAE
                     NPGKKLVPYYTVQEFVESLETPRRILLMVKAGAGTDSAIDSLKPYLDKGDIIIDGGNTF
                     FQDTIRRNRELSAEGFNFIGTGVSGGEEGALKGPSIMPGGQKEAYELVAPILKQIAAVA
                     EDGEPCVTYIGADGAGHYVKMVHNGIEYGDMQLIAEAYALLKGGLALSNEELAQTFTEW
                     NEGELSSYLIDITKDIFTKKDEEGKYLVDVILDEAANKGTGKWTSQSSLDLGEPLSLIT
                     ESVFARYISSLKDQRVAASKVLSGPQAQPAGDKAEFIEKVRRALYLGKIVSYAQGFSQL
                     RAASDEYNWDLNYGEIAKIFRAGCIIRAQFLQKITDAYAQNAGIANLLLAPYFKQIADD
                     YQQALRDVVAYAVQNGIPVPTFSAAIAYYDSYRSAVLPANLIQAQRDYFGAHTYKRTDK
                     EGVFHTEWLE"
ORIGIN
        1 aaagggagtt gtgtgtattc ttttacgtga cagtgaattt aagaatttgg cgggcagatg
       61 cccgggcagt atccgtgtat tatcagttcc aatggatttg tgacatgtac aattttgcaa
      121 aaccgcgtgt tttgcaacca aacaggtgaa gatgaatatg gcgaatttga aagcggttat
      181 tccggtcgca ggactaggca tgcatatgct gccggccaca aaggcaattc caaaggagat
      241 gctgccgatc gttgataagc caatgattca gtacatcgtt gacgaaatcg tcgccgccgg
      301 gatcaaagag attgttctgg tgacgcactc ctcgaagaac gcggtggaaa accacttcga
      361 cacctcctac gagctggaag ccctgctgga acagcgcgtg aagcgccagc tgctggcgga
      421 agtgcaggcc atttgcccgc cgggcgtgac catcatgaac gtgcgtcagg cgcagccgct
      481 gggcctgggc cactccatcc tctgcgcccg cccggtagtc ggcgacaacc cgtttgtggt
      541 ggtcctgccg gatatcatcc ttgacggcgg caccgctgac ccgctgcgct ataacctcgc
      601 cgctatgatc gcccgcttta acgagaccgg ccgcagccag gtgctggcga aacgcatgcc
      661 gggcgatctc tccgaatact ccgtcatcca gaccaaagag ccgatggtgg ctgaaggcca
      721 ggtggcgcgt atcgtcgagt ttattgaaaa accggacgag ccgcagacac tggactccga
      781 tctgatggcg gtggggcgct acgtgctgtc ggcggatatc tggaccgaac tggaacgtac
      841 cgagccgggc gcatggggcc gtatccagct gaccgacgcc attgccgaac tggcgaagaa
      901 gcagtccgtc gacgcgatgc tgatgaccgg cgaaagctac gactgcggga agaaaattgg
      961 ctacatgcag gccttcgtca cctacggcat gcgtaacctg aaagaaggca ccaaattccg
     1021 cgaaagtatt aaaaaaatgc tggcctgatt gctagcgtag tacggggggg cagggcgtga
     1081 acattcgtcc tgccactcat aacgttatgc agaaattatt cataacgcga atgttataac
     1141 gattgtaaag aaacgtatgg cttcggagac ttctggtagt ttgtctctgg cctctgtggt
     1201 gcaatggtcg gagtagcggc aataatgctt tatgaatagt cacttagtgc gacaattcct
     1261 aaagcgcagg gaaagcggtc aacgtcagcc aaaaataaaa cttgactgcg atcatgtttc
     1321 cgctttaaac atctcacttg catgcataaa aatgtgaaat gaattggcat gcgagctggt
     1381 acagacatta cggataatcc ctgagcacgg cagtggacat catcgaagga tcacaggtat
     1441 atgaactggc aactcatctc attttttggc gatagcaccg ttttgctgcc cagcgcagcg
     1501 gcgctgttta ttgtcctgat gctgcgtaaa acgtcgcggt tgctggcgtg gcagtggagt
     1561 ttgctgttcg gcatcaccgg cgctatcgtc tgcgcctcta aactggcctt tatgggctgg
     1621 ggtcttggta ttcgtgaact ggatttcacc ggcttcagcg gccactccgc gctatccgcg
     1681 gccttctggc ctatcttcct gtggctgctc agcgcccgtt tctccgtcgg tctgcgtaaa
     1741 gcggccgtta ttaccggcta tgttctggcc gccgtggtgg gctattcgcg gctggtcatc
     1801 catgcgcatt ccgtctcgga agtgattgcc ggcctgctgc tgggcgctgc tggcagcgct
     1861 ttgttcctgg tgttgcaaaa acgtacccct gatccggaga acgtgaatat ctcatggggc
     1921 ggtgttgcat gcctggtgat ggttccgctt atccttttac atagcggcag caaagcgccg
     1981 actcagtccc tgctgggaca aatcgccacc gcggtggggc cgctggataa accctttacg
     2041 cgtaccgatc tgcacaagca ggcctggtaa tcgccatttg ttttacaggg gaaattaagt
     2101 tttcgccgga taattagaca aataagaaaa taatctacta tatacccggt aattgataat
     2161 tcatatttat gaaataatga agtgctacta cattgttatt gcatatttgc ttggatatag
     2221 ccttgatcag acgtttctta aatgcgctga gacgttacct gatgcacatt caatgaatat
     2281 ccagacacag gaaactatta gaaattgtag ttgactataa cgccatcatc tgatttttgc
     2341 atgatgatga gctatggaaa aagacgtttt tttacagtca gttagctgca tgtgtgatgt
     2401 tgtagcagta ccgggaagat ttctaaccct ggaaatcagt gaataatctt aattggtgac
     2461 ccgcttattt tttgtcagta gaacgacagg cggcattaat tggcagatat tcggtaacaa
     2521 cactcccaat tgtgaccgaa atcccgtaaa cttaacgccg ccaaaaataa tggcctgacc
     2581 aattattcat ccacaggtcg ataaaaatta agtcgttcag gtagtcagtg cgctggtagc
     2641 tgttaagcca ggggcggtag cgtcgctgaa gccgcttgct gctgcacaga ggttctcttc
     2701 aacggctgta aatatcgact cggtcaggat gatcatcatc aatagatatc taacaatttt
     2761 ctacggatat cctcagaagt tggccaggag cgactgctga tatcgcctgg acattaactt
     2821 tcctgtctca tccatagcct gtagggtaaa attcgcctac attgtgagct gagtggatgt
     2881 tataaggcta acaagcagct tagggtaaat gtacttgcct cgccggtgtt gcacagcgaa
     2941 gtcagctggt gccgcgagcg ctttctatct tggtattccc ctcattctca ttgagaaacg
     3001 atagcggggc tgaaaatgga tcttgtacaa tgataaaaat tgcgcgcatt gccgtgacgt
     3061 tgggtttgct ttcctcactg ggagcccagg cttacgcggc cgggttagtg gtaaatgaca
     3121 acgacttacg taacgacctg gcctggcttt ccgatcgcgg ggtcatccat ctgagcctgt
     3181 cgacctggcc gctgagccag gaagagattg ctcgggcgct aaagaaggcc aagccgtctt
     3241 attcttctga gcaagtagtt ctggcccgta tcaaccagcg actgtctgcc ttaaaagcgg
     3301 atttccgggt caccggctac acttcaaccg atcagccggg cactccgcag gggtttggcc
     3361 agacgcagcc ggcagataac tcgttaggcc tggcgttcaa caacagcggc gagtggtggg
     3421 atatccacct ccagggcaac gtcgaagggg gggagcggat cagcaacgga tcgcgcttca
     3481 acgctaacgg cgcctacggt gcggtgaagt tctggaacca gtggctatct tttgggcagg
     3541 tacctcagtg gtgggggccc gggtatgaag gtagcctgat ccgcggggat gcgatgcggc
     3601 cgatgaccgg ttttctgatg cagcgggccg agcaggcggc gccggaaacc tggtggttac
     3661 gctgggtggg gccatggcag tatcaaattt ctgccagtca aatgaatcag tacgcagtaa
     3721 tcccgcatac gaaaattata ggtggtcgat ttacattctc gccttttcag tctttagaat
     3781 tgggcgcgtc acgtattatg cagtggggcg gagaaggtcg gccagagtcg tttagcagct
     3841 tctggaatgg cttaacagga aaagataaca cttctgctaa cgacccaaat gaacctggca
     3901 accaattggc tggattcgac tttaaatata agcttgaacc tactctcggt tggccaatta
     3961 gtttttacgg tcaattgatt ggtgaggatg aggctgggtt tttaccctcc gctaatatgt
     4021 acctcggtgg tatagaaggg catcatggat gggggaaaaa cgcgctaaat tggtatttag
     4081 aagcccatga taccagaaca aacatgagta gaacaggata tagctattgg catcatcttt
     4141 atacagatgg ttattatcaa caaggctact ctcttggtga tgcgatggga ggggatgggc
     4201 agttattagc tggcaaggtc gaacttataa cagaagataa ccaacgttgg agttcacgtc
     4261 tggtttacgc caaagtaaat ccggagaatc agccgataaa caaggcattc cctcatgctg
     4321 ataccttgaa aggagtacag cttggctgga gtggggatgt ttatcagtcg gtccgcttga
     4381 atacttcatt gtggtacacc aacgctaaca acagcgacag cgatgatatt ggagccagtg
     4441 cagggattga gataccgttt agtttataag gctgaatgct gaaaacaggg gagagtaagt
     4501 ggtagcgctg cgggacgcag tcagctttta tctctccaca agccggcagg gaagcaacgg
     4561 tgatgacagc tgctcaggaa ttggcaaatt ttgatttact gatgatgtga cattatgaag
     4621 aaaaaaattg ttagattttc ggcattagca ttggcaattg ggtttttatc gggttgtacc
     4681 attatccctg gtcagggatt aaatagtctg cgcaagaacg tggttgagct tccggacagt
     4741 gattacgatc tggataaact ggttaacgtg tatcccatga ccccaggact gatcgatcag
     4801 cttcgtccgg agactgtact cgctcgtcca aatccgcagc ttgataattt actgcgcagt
     4861 tatgaatatc gcattggggt tggtgacgta ctgatggtta cggtatggga tcacccggaa
     4921 ctgacgacac ctgcaggtca gtaccgtagc gctagcgata ccggtaactg ggttaactcc
     4981 gatggtacca ttttctatcc ttatattggt aaggtgcagg ttgcgggaaa aactctcgct
     5041 caggtacgac aggatatagc cagccgtttg accacctata ttgaaagccc acaggttgat
     5101 gttagtattg ctgcgtttcg ttcgcaaaaa gcctatgtga caggtgaggt tactaaatca
     5161 ggacagcagc caattaccaa tattccatta acggtgatgg atgccattaa cgcggccggc
     5221 gggcttgcgc cggatgcaga ctggcgtaac gttattttaa cccatgacgg gaaggataca
     5281 aaaatttcat tatatgcgtt aatgcaaaaa ggtgatttat cacagaatca tctcctttac
     5341 cctggcgata tactatttgt tccccgtaat gatgacctga aagtatttgt catgggcgag
     5401 gttggaaaac aaagcactct taagatggat cgaagtggta tgactttagc tgaggccatt
     5461 gggaatgcgg aaggtatttc tcaggaattt agtgatgcaa cgggtatctt tgtcgttcgg
     5521 caactgaaag gcgataaaca aggaaagata gccaatgttt accaactaaa tgctcaagat
     5581 gcttcagcga tggtactgag cactgaattt cagttacaac cttatgatat cgtttatgta
     5641 actactgccc cattggttcg atggaatcgg gttatatcgc agttagtgcc cacaattact
     5701 ggtgtacatg atatgactga gacaggtaaa tatattcgaa cttggtgaaa ataatgttta
     5761 attctatttt agttatatgc acaggaaaca tctgtcgttc accttttgca gaaagaatat
     5821 taagaaagaa actgccgaat atgaagattg actcggcagg aactggagcg ttagttgata
     5881 gcgctgctga ttctacagct atgagaattg ctaaatcttt tgatgtttct ttggatggac
     5941 ataaaggtaa acaatttagt gcaaaattag gaagggaata tgatcttatc ttagtgatgg
     6001 aaaaagccca tattacacag attagtagta ttgcacctga agtcagaggt aaaactatgc
     6061 tgttgaatca ttgggttaat caaaaagaca tccctgatcc ttaccgaaaa agtgatgaag
     6121 ctttcgaatc agtttttaat ttgatcgaaa aagcatgcct taaatgggtt gaaaaattaa
     6181 atggataaaa tttgggaaca ttactaatgt cttcaacgaa atcaaataaa cgaatcagcg
     6241 cagatgaaat tgatattggt cgtctgtatg gtgaattaat tgaccatcgt aaattaattc
     6301 ttagtattac tgcaatttca gtatttataa gtattttata ttgcctgttt gctactccag
     6361 tttatcaagc tgatgcttta attcaagttg agcagaagca aggtaatact atacttgaga
     6421 gtttgagtca ggttcttcca gatgcacaac ctcaatcagc acctgaaata tctttgcttc
     6481 aatcaaggat gatattaggt aaaactgtag acgatcttaa attacagact attgtaacaa
     6541 ataattattt ccctattgtt ggtaaaggat gggctcgatt aattggcgaa aattccggta
     6601 atatagatgt tgagaacatg attataccgg agcaaaagct taaggaaaac aataaagcaa
     6661 tactaactgt cattaataat aatgaataca ctgtatctat tgatgatact acttatcatg
     6721 gaaaggttgg tgttcaaata aaagagccaa atttatcatt attaataaat aaaatcgatg
     6781 ctcaacctgg tgatagtttt aagataaaat ataagactag attagaggcg ataaatgatt
     6841 tagcaaattc tttccatgtt gaagaccaag gaaaagatac cggcatgtta gccttgactt
     6901 tgactggaga tgatccatca ttaatttcag tgatacttaa taaaataagt gaaaactatt
     6961 tggaacaaaa tgtctctagg caagccgcac aagatgcaag aagcctcgag tttttaaatg
     7021 aacgtttgcc aaaagtaaga gatgatctgg acagagcaga agataagctt aatagttata
     7081 gaaaacagaa agattccgtc gatctgtcat tagaagctaa agctacatta gatcaattag
     7141 ttaatgttga taatcaaatt aatgaactga cctttcgaga ggctgaaata tcgcagcttt
     7201 ttactaagga tcatccgact tataaagcac ttatcgagaa aaaaaataca ctaagtaaag
     7261 agcgtgggtt attgaacaat agaatttctg cgatgccagc aactcaacaa gaagtattac
     7321 gtctgagtcg tgatgtcgaa tctggacgta ctgtttatat gatgctatta aacagacagc
     7381 aggagctaga aatttctaaa tcaagtgcaa ttggtaatgt tcgtattgtt gatgagtccg
     7441 ttacagagcc agagccagta aaacctaaaa aggcaatggt tgttatatta ggagttcttc
     7501 tcggtggctt aatctctgtt ggggttgtct tactaagagt ttcatttaga agaggaattg
     7561 aatcaccaga gcaattagaa gaggtaggga ttagcgttta ttcaagcata cctgtatcag
     7621 agtggttaga aagtaataat aaaacaaggc atggtgatag ctggaatctg cttgctatag
     7681 ataatccagc tgacttagcc atagaggcaa ttagggggtt aagaacaagc cttcattttg
     7741 ctatgcttga agccaaaaat aatatattaa tgatatcggg cgctagccct aatgctggta
     7801 aaacatttgt tagcagtaat ttggcagtaa ttgaagctca aaccggtaag tctgtattgt
     7861 ttattgatgc cgatatgaga aaggggtact cacataaatt atttggcata aacattggca
     7921 atgataatgt tggattgtcg gaattgcttt caagtaatta tgattttgag aaagcaatta
     7981 ataagatagc agaaatgaaa atagacttca tttctagagg tcaagtacca cataatccgg
     8041 ctgaaatgtt aacaagcatt aaatttgata atttattacg atgggctgca agcaattatg
     8101 acttggttat tgttgatacc ccgccagtcc tagcagtgac agatgctgag attattggtc
     8161 gctatgttgg aacaactttg ttggttgctc gatatgaaac aaacacggtt aaagaaatgg
     8221 aagtcagtat aaaacgtttt gagcgaagcg gtatcaatgt aaaaggttgc atactcaatg
     8281 gcgtaatgaa aaaatctagc tcgtattatg gctatggata taatcattat ggatatacat
     8341 ataatgatga taagtaatac tttttttaat ttcgagccaa aaaattaagt ttattatagg
     8401 gggggggtaa tgtttaaaat tcttcgtgtc attccttcaa tggatccgca aaagggaggt
     8461 ccatctgaag gtatcaaaca gcttcagcaa gagatacata ggcaaggatt aaatataaag
     8521 tgcgatatag tatgcatgga tgatttatca aaagatgtta aagatgttga gtatgctagt
     8581 atttatgcgg taggtaaagg taaaggtgta tattcatatt cagagagttt gaaagattgg
     8641 ttagagaaaa atgtccaaaa atatgatttt gtaataatcc atggtatctg gcaatatcat
     8701 agctatatcg ctagtaaatt atgtattaaa aacagcattc cgtatttttt atatactcat
     8761 ggaatgcttg acccttggtt taaaaaaaat tatccaataa agcatatcaa aaaaatgatt
     8821 tattggatgt taattgagcg aaaggtcgtg aacaatgcgg aggctgtaat atttacaagt
     8881 gaagaggaaa aaatactagc acgtcagtca ttcccactat atgaaccaaa agaatttgta
     8941 actgcatacg gaacttctgg cagtattgtc gataaagaga ttgcaaggag tgcatttaat
     9001 gaaaaattcc cttcgctaaa aggtaaaaaa atacttcttt atatggggag aattcatgaa
     9061 aaaaaaggat gtgatatact aataaattca tatgcaaaaa ttagtaaaga acataatgac
     9121 tatcatttgt tcattgctgg gccggatacg tctgcatacg caaaaactct gaaagatctt
     9181 gtgtcctctt taaatttaaa tgacaaagtt acttggggtg gaatgcttag cggtgatgta
     9241 aaatggggcg cttattattc aagtgagatt ttttgcttag catcacacca agaaaacttt
     9301 ggaatagtcg ttgcagaagc cttatcatgt gaggttcctg ttgttactac tacgaaagtc
     9361 aatatctggc gagaaataga acgcgccgat gctggcatga ttgcaataga taatgatgat
     9421 tcttttactg aatgcttaaa tgagtttatt aaaaaatacg aaaacgatcg tgagagatta
     9481 agagggaatg ccttgagatg ctttaaggaa aactttgaca taaaacttgt agcgacatca
     9541 tttaacaact taatatcctc agaacgataa gatattaacc cttataggag agggacgttg
     9601 agatatcgaa gtttttttaa cttagttttc ggatttctta ttgggcaagg agcaatgttt
     9661 atagcgcaaa cattgttaat ttctaaatct gaagttgcac ttgttggcca aattacaatt
     9721 ggtctagggc tattgacatt agctcagtgg ttggctgatg ctggaggggt ttttttaata
     9781 ccgcgcttgt taggctcaga agaaaatgca cagaaaagat tagcgtgctt tattaatgcg
     9841 agatttattt ttgtcacaat tattgttata agtgttctag tttatcttat tactaaaaat
     9901 tcgtggcatc tgtactacgg actcgtatca tttataattc ctgttttgct aatttcatct
     9961 tttagtgtga ttggctatct cgatttttat aatgaaacga aggcttctgg aacattgtct
    10021 ggagtgtctt ggtcattagc ctcattgcct ttgtattatt catatttcta tgaaggagat
    10081 agatatatca taggtatgag tgctgggctg ctttttgttt taggaaacgc attatttatt
    10141 ataattcaat gcgttaaaat gaaacaagta agcaagaatg gcgggattaa attaatgtat
    10201 aaggatggtt tttgcataaa aaaaataaaa tattcatttt atgatatcat taaatataat
    10261 ttgaactatg ggttttcaca aagttatgga aggttcgtcc cgattttatt aaatacactt
    10321 ttaggccctg tactggctgg gtattacata tatgctaaga gttttgcaaa cattgcaaat
    10381 caatttatag ctttctccag aagagttgag tttagtaatc tgatcgcaat tcataatgga
    10441 agtgtcagga aaatattatc cagtcagtta attagctttg gaattgcatg catatttgcg
    10501 atattttgtt ttggaactga acttatcgag tgtttttaca cattgcctat tggaaataat
    10561 actctattat atatacaaat tatagcgtta attaatctgc tatggtgttt gtcaagctca
    10621 ttttctcaat atttcattgc caaaggaaag ttgggtttta tctgtattac gcaattaatt
    10681 acatatattt tatctttgtc aataatttat tttggtgttg agtatttatc aatttattca
    10741 gtctttgctg ctgaatcaat aatgtatatt gttcaatttt taatcttcat agtgtttttg
    10801 aaaacttata aaaaattata attatcaatc ggtttatcgt gaaccataat tatattgaat
    10861 aagttaaaaa tacaattgtt aatataaaaa tagacaatta agcctggggt ttgaaccatg
    10921 gttaaggtag caatactatt atttattatg caattaaact cgatgctcgc ggttggtctg
    10981 ggatggttac ctcagagcgt tgcattgtct gtgcgagtct gtgtgggagg ctacttacta
    11041 taccattata tccgcaatgg taagatgcat tattctttat atgttctatt attagtaatg
    11101 ctcacattat ttattatcaa taacatgata ttgataatta attttatatt tgtaagtttg
    11161 atgatttatt ccataaaaga taacggagag gaatcaatca tcaaaagtat ctattactcg
    11221 acaattgcgt tatcactaat atttattgta atctctctta atggtatatt acatcctact
    11281 attctttact ctcccgatac aggtagatat cgaaattcat tagggtttat atcacccaac
    11341 tatcctgggt tgattgcttt ttcatgcatt gttgcactat tttcttgcct tggaatgttg
    11401 aaaagcaaag tcggcaaaaa aagtaaaatt cttgtggtta taattgcgtt gttttgtttg
    11461 gttataccgc tattaaccga ttctcgaacc ccgttatata cactaattgt ttcatttatt
    11521 ttttatgtat ttcttaggtt ctcatttttt agattactaa caaggatatt tatcccttta
    11581 gtgcctgcta tttttatggg tttaacgtta tatattgcat tttattacaa tcatgatata
    11641 aatgcactat taagcggtag gccgtactta tattctttat atttgaaaga ctttggttgg
    11701 gccgattatt tattgggtgg ggaaggaacc cagggatttt ctgttgatag ttcatactta
    11761 ttactattat cttgttttgg tgtgttttca tttttaatca ttgctttttt attatataaa
    11821 tgtttagtta ataataaaaa caaatatgtt tatgccatgt ttttttcaat cttcgtttat
    11881 ggattgagcg aatcaataat ggtacggcca gaaatatcag tagtgttttt attttattct
    11941 ttgctcgcta ttaagtccga taaaataatg aatcatgatg agctcaattg tcatacctaa
    12001 aatgcaaaag ctgattatat agcaaaggag gaaaaattgt ctggtgaata tgaaattaac
    12061 tactttagct ttaaaaataa attacatcgc ttaatttggg ggggggtgta tataatattt
    12121 tttaaatatt ctcctgtgcc catgtttaga tataggaatt ttattctttc attatttgga
    12181 gctagacttg gtaacaatgt cagaatctat ccaagtgcta aaatatggat tccaagaaat
    12241 ttaactattg gaaataattc ctccattgga ccaagggcgc aaatttacaa tcagggttct
    12301 atttatatcg gtaatgattc aattattagt caagatgtaa ctatttgtgc gagtacacat
    12361 gattacaaca aacgtgatca tcctcttata ttaaagaatg tagaaattgg gaatagagtt
    12421 tggctttgtg ccgagtcctt tgttggacct ggagttcaag tttttgatgg ggctgtgtta
    12481 ggtgctagag ctgtcgctaa gagaaattta tcttcatggt ctgtatacga tggtaaccca
    12541 tgtaataaac ttaaagaaag aatgaataat gaataagcct aatctaactg ttattatctt
    12601 aacaaaaaat gaacaactac atctaaggcg ttgtttagac tcagttataa atttttgcga
    12661 aagaattgtt attgttgact ctttttctga tgataataca ttggaaatta taaaagagta
    12721 tcctggtata gttgaactct atcaacataa attcatcaac catgctaacc aatttcaatg
    12781 gggcttagat aattcgggag taacaacgga ttgggtaatg aggcttgatg cagatgaata
    12841 tattgaatct gagctccaag ctgagattca aaacaaatta aatttaattg ataaaaataa
    12901 aaattgtatt ttcatcaggc gtaagtactt ttacaaggga aagtggataa aacatggtgc
    12961 ggtatatcca ctaaatctgt tacggatttg gcggaacggc caaggtcgta tagaacaaag
    13021 gtggatggat gaacatatag ttgtcaataa cccacagcct gaatttttca aaggtcatat
    13081 cgtcgattat aatttaaatg atatgaagtg gtggatagaa aaacacataa aatatgcaga
    13141 tagagaagtt gttgatttat taaacattaa atatcaatta tttaatcgtg atgaggatgt
    13201 taggaagcaa ggtggtttcc aagctaggct taaaagaaag gtaaaagaag atttatattt
    13261 caaattatct ccatcattga ggtcactatt gtatttttta tatagatatt tttttcggtt
    13321 gggttttttg gatggctcaa aaggatggga ttttcattta atgcaaggtt tgtggtatag
    13381 aagttacgtt gatattagat ataaggagtt ggatgcactc atttctgata taagcagtga
    13441 tcgtgaaaaa ttaagcgtat tatctaaatc aactggttta agtctctgag gaaataaata
    13501 tgaaaaaggt tgcactaatt acgggcgtta ctggtcagga tggttcttat cttgcagagt
    13561 ttttactcga gaagggatat gaggttcatg gtattaaacg gcggtcttct tcatttaata
    13621 cagatcgtgt tgatcatatt tatcaagatc cgcactcctc aaatccgaag ttccatctcc
    13681 attatggcga tttaactgat acttctaacc tgacgaggct tttatcagaa ataaaacctg
    13741 atgaggtcta caacttagga gctatgagtc acgttgctgt ttctttcgaa tcaccagaat
    13801 atacagcgga tgttgatgct attggtactc ttcgtctact agaggcaatt cgttttttgg
    13861 ggcttgagaa aaaaacccgt ttctatcagg catctacttc tgaactatac ggtttagtgc
    13921 aggaaattcc gcaaaaagag acaaccccat tctatcctcg gtcaccatat gccgtagcga
    13981 aactttatgc atattggatt acggttaact atcgtgagtc atatgggatg tacgcgtgca
    14041 atggtattct gtttaaccat gaatccccac gccgtggcga aacgtttgta acacgaaaaa
    14101 ttacacgtgg gctttccaat attgctcaag gtttagaaaa atgtctttat cttggtaata
    14161 tggactcctt acgagattgg gggcatgcga aagactacgt taaaatgcaa tggttaatgc
    14221 tgcaacaaga gcaaccggaa gattatgtta tagcaactgg cgtccaatac tcggtacgtc
    14281 aattcgttga ctttgccgct tccgagttgg gtattaaatt acgctttgaa gggcatggcg
    14341 ttgatgaagt cggaattgta gagagtgttt ctggtgaaga tgcacctgca gtaaaagtag
    14401 gtgacgtaat tgtagctgtt gatccacggt atttccgtcc tgctgaagtg gaaaccttac
    14461 ttggagaccc ttcgaaagct cacgataagt tgggctggaa accagaaaca accttacaag
    14521 agatggttgt cgaaatggtt agaaaggatc tggaggctgc taaaaaacat tctctactca
    14581 aatcacatgg ttacgaggtt tcgatttctc tggagtaaaa aatgacaatt aagaagagag
    14641 tttttgttgc tgggcataaa ggtatggttg gttcagcaat cgtaagacaa ttgaaaaaca
    14701 gagacgacat tgagctcgta ctgcgttcac gtcaggagct caacctgctt aatgctcaag
    14761 acgtaaataa ttttttcgct aatgagcgta ttgacgaagt gtatttagct gctgcaaaag
    14821 ttggcggaat agttgcgaat aatacttatc ctgctgattt tatatatgaa aatattctca
    14881 ttgaagctaa tatcatacat gctgcacatg taaatgatgt ctataagctt atgtttctag
    14941 gttcatcttg tatttatcca aaatatgcta agcaaccgat tagtgagtcc gaattactac
    15001 aaggaacact tgaatcaacg aatgaacctt atgctatagc aaaaatcgct ggtattaaac
    15061 tctgcgagtc ttataatcgg caatataatc gcgattatcg ttcagtaatg ccaactaact
    15121 tatatggaga aaacgataat ttccatcctt ctaattcgca tgtaattcct gcattactac
    15181 gccgttttca tgaagcaaag ttagaaggtc taccacaagt tgttgtatgg ggtagcggga
    15241 caccgatgcg cgagtttctg catgttgatg atatggctgc tgcatctatt tatgtcatgg
    15301 agcttgataa agcactttgg caggagcaaa cacaaccaat gctgtcacat attaacgtag
    15361 gcactggcgt tgattgttct attaaagagt tagcggaaac aatttcaaaa gttgttggtt
    15421 atcaagggga ggtcgttttt gattctacca aacctgacgg cactcctaga aagttattag
    15481 atgtttcgag attggtaggt ttaggctgga agtatcagat taaccttgaa gcaggcttgg
    15541 cacggactta tgaatggttt ttaagaaatc aacaaagctt ccggagttaa tatgttttta
    15601 gatgataata catttaaaaa tgtaataagg aatacaccac taatttcaat tgatttgatc
    15661 attcaaaatg agaaaggtga gtatttagtt ggtaaaagaa acaaccgccc cgcaaggggc
    15721 ttttggtttg ttcctggagg gcggatacaa aaagatgagt cattggacaa tggtttcgcc
    15781 agactgaccc aaaatgaaat tggcataaaa atgatacgaa atgaaagtac ttttcttggt
    15841 gtctttcaac atttctatga tgacaatttt tttaatactg agttcagtac acactatata
    15901 gtattggcgt atgaaatatc tattatctcc agcggtcttg tatttccaca tgagcaacat
    15961 aatgaatatc actggatgag ggtggatgaa atactaaata atgatttagt acattttaat
    16021 actaaagctt attttatgga tgttgcttag gacttttaag tatgaaatta cttgtatatg
    16081 gcatcaatta tcgtcctgaa ttaactggta ttggcaagta tagtggtgaa atggtgaagt
    16141 ggtttgttga taatggtctt gatgttagag tcattactgc tccgccatat tatcctgcat
    16201 ggaaggttgc aagtgattat tctggatgga aatacacgaa agaaaaacat ccacaaatag
    16261 tatacagatg tcctctttat gtacctaata aaccctcaac aataaagcgt ttattacatt
    16321 tgtccagttt tgcattcagt tcattttttc ctcttgtaat gcaggcgcgt tggaaacctg
    16381 attatattat ttgcgttgta cccacgttat tttatgtgcc aggggctctg ctattaagaa
    16441 aactaactcg tgccaaggta atcattcaca tacaggattt cgaggtcgac gctatgctcg
    16501 gcttgggtat ggctaaaaaa ggtgtgtttg ctacatttgc caaaaagttt gaaaaatggt
    16561 gtctaacgtc tgcagataaa gtgtcctcta tttctaaaac aatgttgttg aatgcttctg
    16621 ataaaggtgt gccacaaagt aatttgatat ttttccctaa ctggtcagaa ctagaaagat
    16681 tcaaaaatgt caaaagtgag cagtcagtca agctgaaaga agaatttgga atagctgagg
    16741 aacaaaaagt tattctttac tcaggcaata taggtgaaaa gcaggggctt gaaatcgtta
    16801 tcagtgctgc acaaaaaatg acagcgaata actatgtttt tttatttgtt ggccaggggg
    16861 gggggaagga aaaattagaa agaatgagcg ctgaactgga tttgaaaaat gttcttttta
    16921 aacctttaca accttatgag ctattaccag cactattaaa tattgccgat tgtcatctcg
    16981 tcgttcaaaa gaaaggcgct gctgatgcgg ttctgccttc taagcttacg aatatcctcg
    17041 ctattggtgg caattctgtt ataactgcag aggaaagtac tgagcttggt cagttatgca
    17101 aaaataatcc tggtatcgca caatgtgttg agcctgaatc tgttgatgct ctcatttctg
    17161 gtattgaaaa atgtttgcta atgccacgtc acaacgatgt agcgatcaaa tatgcaaatg
    17221 cctcacttga tatgaataat gtcctttcaa aattcatagt ggatataaaa agataatatt
    17281 tagcaataac aaggagtgta gtatttaagt tacttctggt ggaaaggatt cctcattttt
    17341 atatcataaa ttattatttt gcatgttcta ttatttaacg aagtaacatt gagaaaattg
    17401 gtgttattta ttgcagttaa tatcacagat ctattttttt atttaagacc attttataat
    17461 ctttattatg gtgtaagagt tcgagattaa tcaaggtatt aacctttaat cttgtaaact
    17521 tcaggatttc tattgcaaat tattatttca taaggttaaa tattttaagg aaatcttcat
    17581 ggcaaccttg tatcatcgga ctcgctcgaa tgcgaatgct tctttgattt caatggctca
    17641 acgcttttcc gatgtggtca taatcttttt gggattatat ttggtatgtc ttattaattc
    17701 agtcccattc gaataccaac atgccctcat gtctttacta tcgttggtca ttttccagat
    17761 gataggtggt ataactgatt tttatcgttc ctggcgtggt gttgcgtttt cgacagagta
    17821 tattttaatc tttaaaaact ggacgcttag cttattaatt gctttaggac ttttatcttt
    17881 agactcatcg atcgatactc gttttttatt tttcattcag tggtacttgc tagttgatgt
    17941 tggttttttt gtatgtcgct cagttatcag attgatctca gggttgctta ggaaatttgg
    18001 ctataacacc cgaagagtgg ctgttgtcgg ctcattacct gcaggaatta atttgctaaa
    18061 aagctttatt gagcagcctt ggctaggctt cgttgttaaa ggtatttacg ataatataaa
    18121 attggatagt gccgaatatg acaatgtacc ttatgctgga aatatagata agcttattca
    18181 ggaagcccgt gagggaaaaa tcgatcgtat ttatattgcg atgagcatgc gcgatgagtc
    18241 taaaataaag gatgtggtta ggcaattaac ggatacaact tgttctgtat tgctaattcc
    18301 tgatattttc acttttaaca tcctccagtc tcgtacagag gaaataaatg gcgtgccggt
    18361 tgttccatta tttgattcac cgctgaatgg cattaatatg gtctttaagc gtcttgaaga
    18421 tataatcgta tcatctttga ttcttattct gatatcacca attcttctgg ttatagctac
    18481 tgctgtaaaa accacgtcga aagggccggt tattttccgc caggtacgtt atggaatgga
    18541 cgggaaacct ataaaagtct ggaagtttcg ctcgatgact gtgatggaaa acgacgataa
    18601 agttattcag gctacaaaaa atgatattcg tgtgactaaa gtcggcaagt ttttacgcag
    18661 cacttcctta gacgaacttc cgcagttctt taatgtactt tttggtcaga tgtccgttgt
    18721 aggacctcga ccacatgcag tttctcataa cgagcaatat cggtccttaa ttcaagggta
    18781 tatgcttcgt cataaagtta agccaggtat cacaggctta gcacaaatta atggttggcg
    18841 tggtgaaact gatactttag aaaaaatgga aaaaagaatc gaatatgatt tgttatatat
    18901 cagaggttgg agcatttggt tagatctaaa aataatattc cttactgttt ttaaaggatt
    18961 tattaacaaa tctgcttatt gataagatgc tgcttaagat aagcattgtg catttatagt
    19021 ccaaaattta tatgttgtgc tagttaacaa attttcacta tgagctctat gtactttggg
    19081 ctaacattat catcacattt aagctgcgaa cgtgtcgcag tgaccacacc agacaggagt
    19141 atgtaatgtc caagcaacag atcggggttg tcggtatggc tgtgatgggg cgtaaccttg
    19201 cgctgaacat cgaaagccgc ggttataccg tctccgtttt caaccgctcc cgtgaaaaga
    19261 ccgaagaagt tattgccgaa aatccaggca agaagctggt tccttactat acagtacaag
    19321 agtttgttga atccctcgaa actccacgcc gtatcctgtt gatggtgaag gccggggctg
    19381 gcaccgacag cgccatcgat tccctgaagc cttacctcga taaaggcgac atcatcattg
    19441 atggcggcaa caccttcttc caggacacca tccgtcgtaa ccgtgagcta tctgccgaag
    19501 gttttaactt tatcggtacc ggtgtttccg gtggtgaaga aggggctctg aaagggcctt
    19561 ccatcatgcc tggtgggcag aaagaagcct atgagttagt tgctccgatt ctgaagcaga
    19621 ttgctgcggt tgctgaagac ggtgagccat gtgtcaccta tatcggtgct gacggtgctg
    19681 gccattatgt gaagatggtt cataacggca tcgagtatgg tgacatgcag ctgattgctg
    19741 aagcttatgc gcttttgaaa ggcggtctgg cactttccaa cgaagagctg gcgcaaacct
    19801 tcaccgaatg gaacgaaggt gagctaagca gctacctgat cgacattacc aaagatatct
    19861 tcaccaagaa ggatgaagaa ggtaagtacc tcgttgatgt cattcttgat gaagcagcaa
    19921 acaaaggtac cggtaagtgg accagccaga gctcactgga tctcggcgaa cctctgtctc
    19981 tgataaccga gtccgtattt gctcgctata tttcttcgct taaagaccag cgtgtagccg
    20041 cgtcgaaagt gctgagtggt ccgcaggccc agccggccgg tgataaagct gaatttatcg
    20101 aaaaagtgcg tcgcgcgttg tacctcggta aaatcgtctc ctatgctcag ggcttctccc
    20161 agctgcgtgc tgcttctgat gaatacaact gggatcttaa ctacggcgag atcgctaaga
    20221 ttttccgcgc tggctgcatc attcgtgcgc agttcctgca gaagatcacc gatgcttatg
    20281 cgcaaaacgc tggcattgct aacctcctgc tggcaccgta cttcaaacag attgctgatg
    20341 actatcagca ggcgctgcgt gatgtagtgg cgtatgccgt acagaatggt attccggtac
    20401 cgactttctc tgctgcaatt gcctactacg acagctaccg ttccgcagtt ctgcccgcta
    20461 acctgattca ggctcagcgt gattactttg gtgcgcacac ctataagcgt actgataaag
    20521 aaggtgtatt ccataccgag tggttggaat aatctttata tgccacagtc aggccatttg
    20581 gcctgactgt tatctattgt tagttattct acaataatct gatcaaagtc atcttatttg
    20641 cacgcctgcg ttatttatcc agctctaata aaccaaatgc ttatctttta agaatttgcc
    20701 atatttatac ttttgtacac ctataataag ctgcttctgg cctcagaata tatctgggtg
    20761 tttaataaca gggttttaat taaaggatat taatatgttg cttcctgtga tcatggctgg
    20821 tggtaccggc agtcgtctct ggccgatgtc tcgcgagctt tacccgaaac agttcctccg
    20881 gctgtacggg cagaactcca tgctgcagga aacc
//
