LOCUS       BGC0000734             16727 bp    DNA     linear   BCT 05-MAY-2000
DEFINITION  Pasteurella multocida capsule biosynthesis gene cluster, complete
            sequence.
ACCESSION   BGC0000734
VERSION     BGC0000734
KEYWORDS    .
SOURCE      Pasteurella multocida
  ORGANISM  Pasteurella multocida
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
            Pasteurellaceae; Pasteurella.
COMMENT     On May 5, 2000 this sequence version replaced AF067175.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:07:31
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16727
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..16727
                     /db_xref="taxon:747"
                     /mol_type="genomic DNA"
                     /organism="Pasteurella multocida"
     subregion       1..16727
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000734"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..16727
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1157..2383)
                     /gene="phyB"
     CDS             complement(1157..2383)
                     /codon_start=1
                     /gene="phyB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Capsule_synth"
                     /gene_kind="biosynthetic-additional"
                     /note="LipB, KpsS homolog"
                     /product="PhyB"
                     /protein_id="AAC67247.1"
                     /sec_met_domain="Capsule_synth (E-value: 8.3e-89, bitscore:
                     287.2, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVLKHNLDELLESSTNYLLLQGPIGPFFTELSAWLKTFHKQVFK
                     INFNSGDEAFYPNSIPQTFAYQGQLDQFDQYLRFFCHQHSIDAIICFGDTRAYHRIAKI
                     VADKQKISFWVFEEGYLRPEYVTLEKGGVNDYSQLPRHANFFLSQAACCSEISAPEKLA
                     KGFIPLATIAIKYYTKAYFNQDKYPDYQHHRILDLKYYIKLWLTSGIKRAYYYWQDRSF
                     GKKVAAGKLGDFFLVPLQVYDDSQVRIHCDYESVDAFLKEILESFIHHAPSALNLIIKH
                     HPMDRGFVDYGHVIKQYKTQYPAFKKRIFYVHDVPTPILLRKGKGMITLNSTSGISALL
                     HRMPVLTLGRASYNFEGLTYQGNLHSFWHNKGLPEAKVFEAYRKYHLSKTQINGSFYSK
                     VILRYPYNQ"
     gene            complement(2393..4483)
                     /gene="phyA"
     CDS             complement(2393..4483)
                     /codon_start=1
                     /gene="phyA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Capsule_synth"
                     /gene_kind="biosynthetic-additional"
                     /note="KpsS, LipA homolog"
                     /product="PhyA"
                     /protein_id="AAC67248.1"
                     /sec_met_domain="Capsule_synth (E-value: 3.7e-98, bitscore:
                     317.8, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTLYDYIRLNMYQEFLIFSKGMLKIPYLSGFFTQRLKMFSPFVT
                     WKKERTCILEWGYKASSKKARHFAQQHDLPYATIEDGFLRSIGLGVDGYPPFSLVYDDI
                     GIYYDINQPSRLENLILSQDVLLQEKVDQVEYAIELICTHNLSKYNHAIDTPLQNTKRP
                     IVLVVDQTYGDMAVTFGNAEQSDFLHMLERAIIENPTAEIWLKTHPDVMCGKKQGYLTE
                     YQQFPRVKVLSEDFNSISLLKHVDKVYCVTSHTGFEALLLGKTVVTFGAAWFSGWGLTD
                     DRHAYIRQLKQSKRRAKRSLLQLFYAAYFQYCRYINPNTGKSGTLFDVIDYLIQAKKVT
                     NQLAGDIYCVGMRFWKRKVVQPFFQFPRCRLHFVLNVHELKRCIHEKAQAKIVVWGHSH
                     IEVVEYAKQQQLPLLRMEDGFLRSVGLGSNLTPPISLVLDDVGIYFDAQSRSRLEDILQ
                     HQSFTLKDLQRAETLKKTLIEQHIGKYNVGHTHLCLTHIRQNKLLVVGQVENDASIQYG
                     SPHIRTNAELLCTVRKNNPQAYIIYKPHPDVVAGNRKNTDRLDDYRQYADFVVEKVNIL
                     DCINQVDEVHTMTSLAGFEALLREKKVHCYGLPFYSNWGLTVDHLSLNRRSRKLSLLEL
                     IAGVLIYYPQYIDPKTKTMIDVQRAVDILIEQRRKIKNNKLHTNYFMNIFMKLKNVYSV
                     LR"
     gene            4832..6700
                     /gene="hyaE"
     CDS             4832..6700
                     /codon_start=1
                     /gene="hyaE"
                     /note="KfiB homolog"
                     /product="HyaE"
                     /protein_id="AAC67249.1"
                     /transl_table=11
                     /translation="MKKVIIIGHKQSNYQDVEKVFQCYGMNPPLPSKREKMSPIEIGHV
                     LNKVLPSFEHTPKNVSLLSNKKSKIKKGNSAKNKSHKHAKTNTIQTTSSIWDNLSLDLM
                     LANIEQNFWGWSDPNAIQILDYWANLDPNIHFVFVYDKPENLFQYHSLEEALKLDKHTV
                     QEKFEEWQTYNEKILTYFNKYKDRSVLLNTQQLQNTKKTSLSEIYKHISAPDALVKKLN
                     EPSLNKEMEIIEVNQDLSHQEECPLSNFIVSQIIKNSPTVTQVYEELQSHADLPYISEQ
                     KLVNDADFALLAWKDMIQKQVDANQYQHEKELELSTIKERQLEVTEKYQLTEQKLSETQ
                     KEIEQIKDENRKVKSEKAKLTASVQSTSKILSEKEKEISCIKSENTKIKEEKIKIDEAY
                     HLTKKTLSDKEKALKTHQDEIEALKIIFNENISVQEDMQEKFQETNKRKQELEQELKAI
                     SDKKALLETENSQKTQVSESLENENKVLLAQLQLIQEELEKLYIDNQVLKAKPRLYGAA
                     DRIKNQLTYRLGYKIQRHGRSLFGLIFLPFILFFTYLGFKREMKKYEWNTLPPIHEYED
                     AHEANRIKSHLSYKLGVLFLQEINNPFKWLTLPYKLIKEGKRFKQG"
     gene            6717..9635
                     /gene="hyaD"
     CDS             6717..9635
                     /codon_start=1
                     /gene="hyaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1123:polyprenol-monophosphomannose synthase ppm1
                     (Score: 50.9; E-value: 2.6e-15)"
                     /gene_kind="biosynthetic-additional"
                     /note="HyaD"
                     /product="glycosyl transferase"
                     /protein_id="AAC67250.2"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.9e-45,
                     bitscore: 144.2, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTLSQAIKAYNSNDYELALKLFEKSAEIYGRKIVEFQITKCKEK
                     LSAHPSVNSAHLSVNKEEKVNVCDSPLDIATQLLLSNVKKLVLSDSEKNTLKNKWKLLT
                     EKKSENAEVRAVALVPKDFPKDLVLAPLPDHVNDFTWYKKRKKRLGIKPEHQHVGLSII
                     VTTFNRPAILSITLACLVNQKTHYPFEVIVTDDGSQEDLSPIIRQYENKLDIRYVRQKD
                     NGFQASAARNMGLRLAKYDFIGLLDCDMAPNPLWVHSYVAELLEDDDLTIIGPRKYIDT
                     QHIDPKDFLNNASLLESLPEVKTNNSVAAKGEGTVSLDWRLEQFEKTENLRLSDSPFRF
                     FAAGNVAFAKKWLNKSGFFDEEFNHWGGEDVEFGYRLFRYGSFFKTIDGIMAYHQEPPG
                     KENETDREAGKNITLDIMREKVPYIYRKLLPIEDSHINRVPLVSIYIPAYNCANYIQRC
                     VDSALNQTVVDLEVCICNDGSTDNTLEVINKLYGNNPRVRIMSKPNGGIASASNAAVSF
                     AKGYYIGQLDSDDYLEPDAVELCLKEFLKDKTLACVYTTNRNVNPDGSLIANGYNWPEF
                     SREKLTTAMIAHHFRMFTIRAWHLTDGFNEKIENAVDYDMFLKLSEVGKFKHLNKICYN
                     RVLHGDNTSIKKLGIQKKNHFVVVNQSLNRQGITYYNYDEFDDLDESRKYIFNKTAEYQ
                     EEIDILKDIKIIQNKDAKIAVSIFYPNTLNGLVKKLNNIIEYNKNIFVIVLHVDKNHLT
                     PDIKKEILAFYHKHQVNILLNNDISYYTSNRLIKTEAHLSNINKLSQLNLNCEYIIFDN
                     HDSLFVKNDSYAYMKKYDVGMNFSALTHDWIEKINAHPPFKKLIKTYFNDNDLKSMNVK
                     GASQGMFMTYALAHELLTIIKEVITSCQSIDSVPEYNTEDIWFQFALLILEKKTGHVFN
                     KTSTLTYMPWERKLQWTNEQIESAKRGENIPVNKFIINSITL"
     gene            9699..10871
                     /gene="hyaC"
     CDS             9699..10871
                     /codon_start=1
                     /gene="hyaC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 318.3;
                     E-value: 1.1e-96)"
                     /gene_kind="biosynthetic-additional"
                     /note="HyaC"
                     /product="UDP-glucose dehydrogenase"
                     /protein_id="AAC67251.2"
                     /transl_table=11
                     /translation="MKKITIAGAGYVGLSNAVLLAQHHNVILLDIDQNKVDLINNKKSP
                     ITDKEIEDFLQNKSLTMMATTDKEVALKNADFVIIATPTDYNTETGYFNTSTVEAVIEQ
                     TLSINPQATIIIKSTIPVGFTENMREKFNTPNLIFSPEFVREGKALYDNLYPSRIIVGS
                     TSYQAKVFADMLTQCARKKDVTVLFTHNTEAEAVKLFANTYLAMRVAFFNELDTYASLH
                     HLNTKDIINGISTDPRIGTHYNNPSFGYGGYCLPKDTKQLLANYADVPQNLIEAIVKSN
                     ETRKRFITHDVLNKKPKTVGIYRLIMKSGSDNFRASAILDIMPHLKENGVEIVIYEPTL
                     NQQAFEDYPVINQLSEFINRSDVILANRSEPDLNQCSHKIYTRDIFGGDA"
     CDS             10864..12297
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyl transferase"
                     /product="HyaB/HyaA fusion protein"
                     /protein_id="AAC67252.2"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-36,
                     bitscore: 115.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLNLFKIIKKYVHIQSLLHKKEYALLYAKYINLLSINQQAYVICQ
                     LKLYDLFLIDPKWSHSVFFQLGLIARGHAHDNDEMVRRLITCTDFSKNKQLILSQLLAY
                     SPQIATTLCPKTYRYRALYLSLVANLKDFVRLKEELNKLPSCVLKNTPHYCLLQNFVEK
                     ENSKKLENINQFLYFYKLGEITTIKTEDPPNTNNIVSHSMVNDTNTYLNAPLITILVTT
                     FNSQKSIKNTLNSLFNQSYPNIEIIVIDDHSQDNTMSILQAYTKQYKNIKIISLKENVG
                     TYVAKNIGLKYASGEFITCQDSDDWAHPQKLALQVAPLLQHKELIVTFSKWVRLDPIGN
                     PYARTIYPLMRLNPSSALFRKKEVCEKTALWDWVRIGADSEFNARLKLIFGHKGYYTVN
                     KPLTFGAHRENSLMTAQSTGYVNGVSLPREAYWKAWNIWHISQLQRGHAPLLSSSPKRE
                     FFQYDQHPIMDVISYAIIN"
     gene            12316..13497
                     /gene="hexD"
     CDS             12316..13497
                     /codon_start=1
                     /gene="hexD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Poly_export"
                     /gene_functions="transport (smcogs)
                     SMCOG1186:polysaccharide export protein (Score: 298.5;
                     E-value: 8.7e-91)"
                     /gene_kind="transport"
                     /note="CpxD, BexD homolog"
                     /product="HexD"
                     /protein_id="AAC67254.1"
                     /sec_met_domain="Poly_export (E-value: 3.1e-21, bitscore:
                     64.7, seeds: 183, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKPIKTLSISFITTLILAGCHSMPTSGPAQNHIIGLKKPQNESLP
                     SVDVIEMNDKVAHTLFKQKQSQSFTQFKQQNSNYADIINVGDTLDVLIWEAAPAILFGS
                     VLSQTGSGGANLTTLPEQIVARNGKITIPFLGPILVKGKTPEQIQRDIAHALSSLANKP
                     QVIVRLNKNNSKNVTILRQGNSVRMPLTSQGERVLDAIAAVGGATENLQDISVQLTRGK
                     EVKMLSLEKLATHPEENILLRSNDVVTLLNKPLSFTGLGALGTNKQVKFSANGLTLAEG
                     IGEMGGLLDNRADPKGVFVFRYIPFNKLSLAEQTKWKARGYDNDMEIPTVYSVNLLNPN
                     ALFWLQRFPIQDKDLVYVSNAPMAEFQKFLKLVFSITSPVTGTLHNINVIKNL"
     gene            13507..14643
                     /gene="hexC"
     CDS             13507..14643
                     /codon_start=1
                     /gene="hexC"
                     /note="BexC, CpxC homolog;
                     MIETKIQKNQFKKWSRKFRKISTLFKYMVILPTCCSLFYFSLWASDIYISQSSFVVRT
                     PKNQAALSGVGALLQSSGFARAQDDTYTVQEFMRSRSTLELLEKSIPIRQFYEDKGDL
                     FSRFNPLNIFSEQEAFYQYFSKKLSVNFDSVSGIATLNIRAFDPKEAQQINQELLKQG
                     EYLINRLNERARKDTVMFAELAVSEAEKKVTETSSALSEYRIKNGVFDLQSQSEVQLS
                     LISTLQNELITIQTQLDQVRSISPNNPQVQTLLARANSIRKEMQQQVQQVLGGGNSIV
                     TQTAEYQRLVLNNTLAQQQLGTAITSLQNARSEADRQQLYLEIISYPNEPDLALEPYR
                     LYNILATLFISLILYGITLLLLASIREHKN"
                     /product="HexC"
                     /protein_id="AAC67255.1"
                     /transl_table=11
                     /translation="MIETKIQKNQFKKWSRKFRKISTLFKYMVILPTCCSLFYFSLWAS
                     DIYISQSSFVVRTPKNQAALSGVGALLQSSGFARAQDDTYTVQEFMRSRSTLELLEKSI
                     PIRQFYEDKGDLFSRFNPLNIFSEQEAFYQYFSKKLSVNFDSVSGIATLNIRAFDPKEA
                     QQINQELLKQGEYLINRLNERARKDTVMFAELAVSEAEKKVTETSSALSEYRIKNGVFD
                     LQSQSEVQLSLISTLQNELITIQTQLDQVRSISPNNPQVQTLLARANSIRKEMQQQVQQ
                     VLGGGNSIVTQTAEYQRLVLNNTLAQQQLGTAITSLQNARSEADRQQLYLEIISYPNEP
                     DLALEPYRLYNILATLFISLILYGITLLLLASIREHKN"
     gene            14643..15440
                     /gene="hexB"
     CDS             14643..15440
                     /codon_start=1
                     /gene="hexB"
                     /note="BexB, CpxB homolog"
                     /product="HexB"
                     /protein_id="AAC67256.1"
                     /transl_table=11
                     /translation="MLYDDQTTLKHAFIIQNRVIGALLMREIITRYGRKNLGFLWLFVE
                     PLLMTGLIVILWSTFRADQFSNLNIMAFMITGYPLMMMWRNASNRAIGAVSANSTLLYH
                     RNVRVLDTLIARMILEISGATIAQVVLMSFCIALDWIPMPQDIFYMLLAWFLMAIFAIG
                     FGFIICSISHHIEVFGKLWGILSFAMMPLSGTFFFVYNLPPQAREYLLWMPMIHGSEMF
                     RHGYFGDSVITLENPYFLILCDLIFLLIGLLMVAHFSKGIEPR"
     gene            15437..16096
                     /gene="hexA"
     CDS             15437..16096
                     /codon_start=1
                     /gene="hexA"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 117; E-value:
                     1.8e-35)"
                     /gene_kind="transport"
                     /note="BexA, CtrD homolog; ATP-binding protein"
                     /product="HexA"
                     /protein_id="AAC67257.1"
                     /transl_table=11
                     /translation="MIYVENVCKKYLNRTGWHTVLDDVSFSLRKGQKVGILGKNGAGKS
                     TLIRLLSGVEPPTSGKITRKMSISWPLGFSGAFQGSLTGMDNLRFIARIYNADIDYVKR
                     FTEEFSELGKYLYEPVRTYSSGMKARLAFALSLSIEFDCYLIDEIIAVGDARFADKCKY
                     ELFEKRKDRSLILVSHSPNAIREYCDNAMVLHNGIMHHFNSIDIAYQFHNNALQTK"
ORIGIN
        1 tggcgttggc taaccggtaa attttctgga aattcaattg ttttgaccgc atttttacgt
       61 tgcgttaaaa cgcagttgag cgagttggat ctgctcttca atttcagtgg caaccgtttg
      121 ttgcgtttgt acatttttaa tgctggatag ccccttaata cgtgccaaca actggcgata
      181 atccacattc atcacatctt ttaattgtgt gaaaagtgcc tgttgcaagg tattaaatgg
      241 gctgttctta gtgctttttt tcatcatgac ttatttttat aacttctata agctaacatc
      301 gcccaaccaa ttagaaataa cgtgccacca attggcgtta accaagcaac ggattttgtt
      361 gcccctaacg ctaaggcgta caaactacca ctaaagagga caatacctaa actccaggtt
      421 gaaccaatcc agtttatcac tcgatctatg tctgctttta aatatagctg caaagtaccc
      481 aataccatca acgcgacggt atgaaagaat tgatatttta agccggtttc aatccaggca
      541 agggcttttg gcgtcaaggt tttttctaag ccatgcgccg caaatgcacc gaatgcaata
      601 cagaaaaagc cgctcagtgc ggcaataaat aaccatttat ttttcatctt gtcctcttaa
      661 caataatttt aagattttcc taagaataaa gataagatcc ccgcggcgat taacggtcca
      721 actggaatac cgccaacaaa agcaacacca agaatggtcc ctaccaataa tccagttaat
      781 aatacaggtt gtgcgcccat taatccaaca ccacgcccgc ctaaccaagc cactaataat
      841 ccaacggcaa cagcaagcca cattttccaa tttagaaaaa ccgccaaatg cggtagctga
      901 attttacctg acacaattgg acttagcacg ccaatcgtca aaataataat acccaatgtg
      961 atgccgtgct tttccataaa aggaatgtat ttggctaaaa aagtttgctg catcaataac
     1021 aaaattgcag cagagatggt gacggaacta ttattactga gtacgcccag taaaattaaa
     1081 accaccagta ataaggcgac ggtattaaat tgtaaagaca taattttctc tagtttgaac
     1141 ttaaaggtta aaatagttat tgattataag gatagcgtaa aatgactttg ctatagaaac
     1201 tcccattaat ctgtgtttta gataagtgat actttcgata tgcttcaaac actttcgcct
     1261 ctggcaatcc cttattatgc cagaaactgt gcaaattacc ttgataagtt aatccttcaa
     1321 agttgtaact tgctctgcct aaggtcaaaa ctggcatacg gtgtaacaag gcagaaattc
     1381 cacttgtact atttaaggta atcattccct tcccttttct caataaaatg ggtgtcggaa
     1441 cgtcatgaac ataaaagatt cgctttttaa acgcgggata ttgtgtttta tattgtttaa
     1501 ttacatgccc ataatcgaca aatcccctat ccattgggtg atgcttgata atcaaattaa
     1561 gtgcgctcgg agcatgatga ataaatgact ccaagatttc ctttaaaaaa gcgtcaacac
     1621 tttcatagtc acaatgtatt ctcacttgac tatcatcata cacttgcaaa ggcacgagga
     1681 aaaaatcccc taatttaccc gctgctactt tcttcccaaa agaacgatct tgccaataat
     1741 agtaagctct ttttattcct gaagttagcc ataacttaat ataatatttc aaatctaaaa
     1801 tacgatgatg ttgataatca ggatatttat cttgattaaa gtaggctttg gtatagtatt
     1861 ttatcgcaat agttgccaat ggaataaagc cttttgctaa tttttctggt gccgagatct
     1921 ccgagcaaca cgcggcttgt gataaaaaga agttagcatg acgaggtaat tgcgaataat
     1981 cattaacgcc ccctttttct agggttacat attctggtct taaatagcct tcttcaaaaa
     2041 cccaaaacga aattttctgt ttatctgcaa cgattttagc aatgcgatga taagcccgtg
     2101 tatcaccaaa acaaatgatc gcatcaatcg aatgttggtg acaaaaaaaa cgaagatact
     2161 ggtcaaactg atctaactgt ccctggtatg caaaagtctg aggaatagaa ttaggataaa
     2221 aagcctcatc accagaatta aaatttattt taaatacttg tttgtgaaac gtttttagcc
     2281 atgctgacag ttctgtaaaa aaaggaccaa ttggaccttg taataataaa tagttcgttg
     2341 atgattcaag taattcatct aaattatgct taagcacatc catattaaga cactacctca
     2401 aaacagaata aacatttttt aatttcataa aaatgttcat aaaataattt gtatgtaatt
     2461 tattattttt tatttttcga cgttgctcga tcagaatatc aaccgctcgc tgcacatcga
     2521 tcattgtttt tgtttttggg tcaatatatt gtgggtaata aatcagcaca ccagcaatta
     2581 attctaaaag acttaacttc cgacttcttc ggtttagaga aagatgatcc actgttagcc
     2641 cccagttaga ataaaaaggc aagccataac aatgtacttt tttctcgcgc agtaacgctt
     2701 caaaccccgc taaagaggtc attgtatgca cttcatccac ttggttaatg caatccaata
     2761 tattgacttt ctcaaccacg aaatcagcat actgtcgata atcatctaga cgatctgtgt
     2821 ttttacgatt gccagcaacc acatcgggat gaggtttata aataatatag gcttggggat
     2881 tattttttct gaccgtacat aataactctg cattcgtacg aatatgcggt gaaccatatt
     2941 gaattgaagc atcattttcc acttgtccca caactaaaag tttattttgt ctgatgtgtg
     3001 ttaggcataa gtgtgtatgt cccacattat atttaccaat atgttgctca atcagtgttt
     3061 tctttaacgt ttctgcgcgc tgtaaatcct ttagagtaaa ggattgatgc tgtagaatat
     3121 cctctaatcg ggaacgagat tgggcgtcaa aataaatgcc aacgtcatct aaaactaatg
     3181 atatcggtgg cgttaaatta gaccctaacc caactgaacg taaaaaacca tcttccattc
     3241 tcaaaagagg aagttgctgt tgcttggcat attcaaccac ttcaatgtgt gaatgtcccc
     3301 acaccactat tttagcctga gctttctcgt gaatacatcg ctttagctca tgcacattca
     3361 gcacaaaatg taaacgacag cgtggaaatt gaaaaaaggg ttgaaccact ttacgtttcc
     3421 aaaagcgcat acccacacaa taaatatcac cagctaactg attggttact ttttttgctt
     3481 gaatcagata atcaatgaca tcaaacaatg tgcctgattt acccgtatta ggattaatat
     3541 aacgacaata ttggaaataa gcagcataga ataactgcaa caatgaacgc ttcgctcttc
     3601 tcttactctg ttttagctga cgaatatacg catgccgatc atccgtcaat ccccaaccag
     3661 aaaaccaggc agccccaaaa gtcacgacag tttttcctaa caaaagggcc tcaaacccag
     3721 tgtgagatgt cacgcaataa actttatcaa catgctttag tagtgagata gaattaaaat
     3781 cttctgataa tacttttact cttggaaatt gctgatattc cgttaaatag ccttgttttt
     3841 taccacacat tacatcagga tgggttttta accagatttc tgctgttgga ttttcaataa
     3901 tcgcacgttc taacatatgt agaaaatcac tctgctcggc attcccgaaa gtaactgcca
     3961 tatcgccata tgtttgatca acgactaaga caatcggcct cttcgtattc tgtaaaggtg
     4021 tatcaatagc gtggttatat ttggaaaggt tatgtgtaca aattaattca attgcatatt
     4081 caacttgatc gactttttcc tgaagtaata catcttgaga aagaattaag ttttctaaac
     4141 gagaaggctg attgatatca taataaatac caatatcatc gtacactaat gagaaaggtg
     4201 gatacccatc cacacccagt ccaatagaac gtaaaaaacc atcttctatc gtcgcataag
     4261 gtaaatcatg ttgttgtgca aaatgcctcg ctttctttga tgatgcttta tatccccatt
     4321 ctaaaataca tgttctctcc tttttccatg tgacaaatgg agagaacatt ttcaagcgtt
     4381 gggtaaaaaa accgcttaaa taaggaattt ttaacatccc tttagaaaaa ataagaaact
     4441 cttgatacat atttaatcta atatagtcat ataaagttga catatcatat attaaacatg
     4501 actagttaat cattaaatat taaacaacct caacttaata aaacaaataa taaacaaaca
     4561 aggtaaaaaa caaactaata ctgagcaaat aaaaaacgga ttaatataat aacgatatat
     4621 caacctctaa aacagaccaa aaataaatca cacgagacaa aagaacaatt ataatccaaa
     4681 tattaattaa taaataaaca cctagcgcaa cgaataatca aacaaaatca catttagatt
     4741 tatttaaatt aaaaatatag attatatttt aaatataatg ctagaattcg gcaccaaaat
     4801 ttttctccag ctgtaaatta gagataaaga tatgaaaaag gttattatca ttggacataa
     4861 acagtctaac tatcaagatg ttgaaaaggt ttttcaatgt tatgggatga atcccccgct
     4921 tccatcaaaa cgtgaaaaaa tgtcccccat cgaaattggc catgtgctta ataaagtatt
     4981 accaagtttt gagcacacac ctaaaaatgt atctttactt tctaataaga aaagcaaaat
     5041 aaaaaaaggg aattcagcca aaaataaatc tcataagcac gctaaaacga acacaataca
     5101 aacgacttcg agcatctggg ataacttatc tctcgatttg atgctcgcga atatcgagca
     5161 aaatttttgg ggatggtctg atcctaatgc aattcaaata ttagattatt gggctaacct
     5221 tgacccaaac attcatttcg tctttgttta tgataagcca gaaaatttat tccaatatca
     5281 tagcttagaa gaggctctca aattagataa acacaccgta caagaaaaat ttgaagagtg
     5341 gcaaacctac aatgaaaaaa tcctaactta ctttaataaa tataaagatc gtagtgtatt
     5401 actgaataca caacaactcc aaaatactaa aaaaacatca ctgtctgaaa tttataaaca
     5461 tatttctgca cctgatgcat tagtcaaaaa actgaatgaa ccttctctaa ataaagagat
     5521 ggaaattatt gaagtaaacc aagatttatc tcaccaagaa gaatgtccac tgtctaactt
     5581 tattgttagc caaattataa aaaattctcc tactgttacg caggtatatg aagaattaca
     5641 gtcgcatgct gatctgcctt atatttcaga acaaaaatta gtaaatgatg ccgattttgc
     5701 tctccttgca tggaaagata tgattcaaaa acaagtcgat gcaaatcaat atcaacatga
     5761 aaaagaatta gaacttagca caataaaaga acgtcaatta gaggtcacag agaaatatca
     5821 attgacggaa caaaaactgt cagaaacaca aaaagaaatc gaacaaatta aagatgaaaa
     5881 tagaaaagta aaatctgaaa aagcaaaact cactgcatct gttcaatcaa cgagcaaaat
     5941 actttctgag aaagaaaaag agatttcttg cataaaaagt gaaaatacaa agattaaaga
     6001 agaaaaaatt aaaattgatg aagcatacca cttaaccaag aaaaccttgt cggataaaga
     6061 aaaagccctc aaaacgcatc aagatgaaat tgaagcgctc aagataattt ttaatgaaaa
     6121 tatttccgta caagaagata tgcaagaaaa atttcaggaa accaataaaa gaaaacaaga
     6181 acttgaacaa gagctaaaag ccatatcgga taagaaagca ttattagaaa cagaaaacag
     6241 ccaaaaaacc caagtatctg agtctttaga aaatgaaaat aaagtgttat tagctcagct
     6301 ccaactcatt caagaagaat tagaaaaact ttatattgac aatcaagtat taaaagctaa
     6361 accacgcctt tacggtgcag ctgatcgcat aaaaaaccaa ttaacttatc gactaggtta
     6421 caaaatacaa agacatggaa gaagtctatt tggtctcatt tttcttcctt tcatcttatt
     6481 tttcacctat ctgggcttta aaagagagat gaaaaagtac gagtggaata cgctcccacc
     6541 aattcatgaa tatgaagatg cgcatgaagc caatcgcatt aaaagccatt tatcttataa
     6601 attgggcgtc ctctttttgc aagaaatcaa caatccgttt aagtggctta ctctccctta
     6661 taaactgatt aaagaaggta aacgattcaa gcaaggttaa tttttaagga aagaaaatga
     6721 atacattatc acaagcaata aaagcatata acagcaatga ctatgaatta gcactcaaat
     6781 tatttgagaa gtcggcggaa atctatggac ggaaaattgt tgaatttcaa attaccaaat
     6841 gcaaagaaaa actctcagca catccttctg ttaattcagc acatctttct gtaaataaag
     6901 aagaaaaagt caatgtttgc gatagtccgt tagatattgc aacacaactg ttactttcca
     6961 acgtaaaaaa attagtactt tctgactcgg aaaaaaacac gttaaaaaat aaatggaaat
     7021 tgctcactga gaagaaatct gaaaatgcgg aggtaagagc ggtcgccctt gtaccaaaag
     7081 attttcccaa agatctggtt ttagcgcctt tacctgatca tgttaatgat tttacatggt
     7141 acaaaaagcg aaagaaaaga cttggcataa aacctgaaca tcaacatgtt ggtctttcta
     7201 ttatcgttac aacattcaat cgaccagcaa ttttatcgat tacattagcc tgtttagtaa
     7261 accaaaaaac acattacccg tttgaagtta tcgtgacaga tgatggtagt caggaagatc
     7321 tatcaccgat cattcgccaa tatgaaaata aattggatat tcgctacgtc agacaaaaag
     7381 ataacggttt tcaagccagt gccgctcgga atatgggatt acgcttagca aaatatgact
     7441 ttattggctt actcgactgt gatatggcgc caaatccatt atgggttcat tcttatgttg
     7501 cagagctatt agaagatgat gatttaacaa tcattggtcc aagaaaatac atcgatacac
     7561 aacatattga cccaaaagac ttcttaaata acgcgagttt gcttgaatca ttaccagaag
     7621 tgaaaaccaa taatagtgtt gccgcaaaag gggaaggaac agtttctctg gattggcgct
     7681 tagaacaatt cgaaaaaaca gaaaatctcc gcttatccga ttcgcctttc cgtttttttg
     7741 cggcgggtaa tgttgctttc gctaaaaaat ggctaaataa atccggtttc tttgatgagg
     7801 aattcaatca ctggggtgga gaagatgtgg aatttggata tcgcttattc cgttacggta
     7861 gtttctttaa aactattgat ggcattatgg cctaccatca agagccacca ggtaaagaaa
     7921 atgaaaccga tcgtgaagcg ggaaaaaata ttacgctcga tattatgaga gaaaaggtcc
     7981 cttatatcta tagaaaactt ttaccaatag aagattcgca tatcaataga gtacctttag
     8041 tttcaattta tatcccagct tataactgtg caaactatat tcaacgttgc gtagatagtg
     8101 cactgaatca gactgttgtt gatctcgagg tttgtatttg taacgatggt tcaacagata
     8161 ataccttaga agtgatcaat aagctttatg gtaataatcc tagggtacgc atcatgtcta
     8221 aaccaaatgg cggaatagcc tcagcatcaa atgcagccgt ttcttttgct aaaggttatt
     8281 acattgggca gttagattca gatgattatc ttgagcctga tgcagttgaa ctgtgtttaa
     8341 aagaattttt aaaagataaa acgctagctt gtgtttatac cactaataga aacgtcaatc
     8401 cggatggtag cttaatcgct aatggttaca attggccaga attttcacga gaaaaactca
     8461 caacggctat gattgctcac cactttagaa tgttcacgat tagagcttgg catttaactg
     8521 atggattcaa tgaaaaaatt gaaaatgccg tagactatga catgttcctc aaactcagtg
     8581 aagttggaaa atttaaacat cttaataaaa tctgctataa ccgtgtatta catggtgata
     8641 acacatcaat taagaaactt ggcattcaaa agaaaaacca ttttgttgta gtcaatcagt
     8701 cattaaatag acaaggcata acttattata attatgacga atttgatgat ttagatgaaa
     8761 gtagaaagta tattttcaat aaaaccgctg aatatcaaga agagattgat atcttaaaag
     8821 atattaaaat catccagaat aaagatgcca aaatcgcagt cagtattttt tatcccaata
     8881 cattaaacgg cttagtgaaa aaactaaaca atattattga atataataaa aatatattcg
     8941 ttattgttct acatgttgat aagaatcatc ttacaccaga tatcaaaaaa gaaatactag
     9001 ccttctatca taaacatcaa gtgaatattt tactaaataa tgatatctca tattacacga
     9061 gtaatagatt aataaaaact gaggcgcatt taagtaatat taataaatta agtcagttaa
     9121 atctaaattg tgaatacatc atttttgata atcatgacag cctattcgtt aaaaatgaca
     9181 gctatgctta tatgaaaaaa tatgatgtcg gcatgaattt ctcagcatta acacatgatt
     9241 ggatcgagaa aatcaatgcg catccaccat ttaaaaagct cattaaaact tattttaatg
     9301 acaatgactt aaaaagtatg aatgtgaaag gggcatcaca aggtatgttt atgacgtatg
     9361 cgctagcgca tgagcttctg acgattatta aagaagtcat cacatcctgc cagtcaattg
     9421 atagtgtgcc agaatataac actgaggata tttggttcca atttgcactt ttaatcttag
     9481 aaaagaaaac cggccatgta tttaataaaa catcgaccct gacttatatg ccttgggaac
     9541 gaaaattaca atggacaaat gaacaaattg aaagtgcaaa aagaggagaa aatatacctg
     9601 ttaacaagtt cattattaat agtataactc tataaaacac ttgcatttta ttaaaaataa
     9661 aatcctataa tatttgcagt ttaaataaag gataaaaaat gaagaaaatt acaattgctg
     9721 gggctggcta tgttggttta tccaatgcag tattattagc tcaacaccac aatgtgatct
     9781 tattagatat tgatcaaaat aaagttgatt taattaataa taaaaaatcg cccatcacag
     9841 ataaagaaat cgaagatttc ttacaaaata aatcactgac aatgatggca acaacagata
     9901 aagaagtggc attaaaaaac gcagactttg tcatcatcgc aacgccaaca gactataata
     9961 ccgaaacagg ttattttaat acatccactg ttgaagctgt cattgaacaa accctttcaa
    10021 tcaatccaca agcaacgatt attataaaat caacaattcc cgttggtttt accgaaaaca
    10081 tgcgtgaaaa atttaatacc ccaaatctta tcttttcacc tgaatttgta agagagggaa
    10141 aagcccttta cgataatttg tatccaagca gaattattgt tggcagtact tcttatcaag
    10201 caaaagtatt tgccgatatg ttaacacagt gtgccagaaa aaaagatgta actgttttat
    10261 ttacacacaa tactgaggcc gaagctgtta aattatttgc aaatacgtat ctcgcaatgc
    10321 gagttgcctt ttttaatgaa ttagatactt atgcgagtct tcaccattta aatacaaaag
    10381 acattatcaa tggtatttct actgatcctc gcattggtac acactacaat aacccaagtt
    10441 tcggctatgg cggttattgt ttacccaaag acactaaaca gttactggct aactatgctg
    10501 acgtgcctca aaatctcatt gaagccattg tcaaatctaa tgaaaccaga aaacgtttca
    10561 ttactcatga tgtattaaat aagaaaccta aaactgttgg tatttatcgt ttaatcatga
    10621 agtcaggttc tgataacttc agagcttctg ctattctcga tattatgccg catctcaaag
    10681 aaaacggtgt tgaaattgtg atttatgagc caaccttaaa tcaacaggca tttgaggact
    10741 accccgttat taatcaactc tctgaattta ttaatcgctc tgatgtcatt ctcgctaatc
    10801 gttctgagcc cgatttaaat caatgttccc ataaaatcta tacaagagat atttttggcg
    10861 gtgatgctta acctgtttaa aatcataaaa aagtatgtac atattcaatc tttattacac
    10921 aaaaaagaat atgccttact ttatgctaaa tacataaacc tgctttctat caaccagcag
    10981 gcttatgtta tttgtcaact caaactctat gatctctttt tgattgatcc taaatggagc
    11041 cactctgttt ttttccagtt aggattaatt gctcgtgggc acgctcatga taacgatgaa
    11101 atggtacgtc gtttgatcac ttgcactgat tttagcaaaa ataagcagtt aatcctttct
    11161 caattacttg cttattcacc ccaaattgca acaacattat gtccaaagac atatcgttat
    11221 cgtgcgctat atctctcatt agtagcgaat ttaaaagact ttgttcgttt aaaagaagaa
    11281 ctcaataagt tgccgtcatg tgtgttaaag aatacacctc attactgttt gttacagaat
    11341 tttgtcgaaa aagaaaacag caagaaatta gagaacatta atcaatttct ttacttttat
    11401 aaacttggag aaataactac gataaagaca gaagatccac ctaatactaa taatatagtc
    11461 agtcattcga tggttaatga cacaaacacc tacttaaatg cccccttaat taccatatta
    11521 gtgacgacat ttaacagtca aaaaagtata aaaaacacat taaattcatt gttcaatcaa
    11581 agctatccaa atattgaaat tatcgttatt gatgatcata gccaagataa tacgatgagt
    11641 attctccagg cttatactaa gcaatataaa aatatcaaaa ttattagctt aaaagaaaat
    11701 gtcgggactt atgtcgcaaa aaatattggt cttaaatacg cctctggcga attcatcact
    11761 tgtcaagatt ccgatgattg ggcacaccca caaaaattgg cacttcaggt ggctccttta
    11821 ttacaacata aagagttaat tgtaactttt tctaagtggg taaggctcga tccaataggg
    11881 aatccttatg cccgtactat ttatccatta atgcgtttaa acccttcttc cgcattattc
    11941 cgtaaaaaag aagtgtgtga aaaaactgca ttatgggatt gggtaagaat cggtgcagat
    12001 agcgaattta atgcacgctt aaaattaatt tttggacaca aaggctatta caccgtgaat
    12061 aaacctttga cattcggtgc acatcgagaa aattcattaa tgacagctca aagtactggc
    12121 tatgtcaatg gcgtctccct acctcgtgaa gcatattgga aagcatggaa tatctggcat
    12181 atttcacaat tacagcgagg acacgcccct cttttatctt cctctcctaa acgagaattt
    12241 tttcaatatg accaacatcc gatcatggat gttatttctt atgcaatcat taattaaatc
    12301 ttaagagaga ttattatgaa accaataaaa acattatcta tttcttttat cacaacgctc
    12361 atcctcgctg gctgtcatag catgccaact tcgggacccg ctcaaaatca tattattggg
    12421 ttaaaaaaac cacaaaatga gagcttgcca agtgttgatg tgattgaaat gaatgataaa
    12481 gtagcacaca ctttgtttaa acaaaagcaa tcgcaatcct ttactcaatt caaacagcaa
    12541 aatagcaact atgcagatat cattaatgtt ggcgatacat tagatgtgtt gatttgggaa
    12601 gccgcacccg ctattttatt cggcagtgtt ctgtcacaaa ctggtagtgg cggtgcaaat
    12661 ctcacgacat tacccgaaca aattgttgca cgcaatggaa aaatcacaat cccattttta
    12721 ggccctatct tagtaaaagg caaaacacca gagcaaattc aaagagatat tgctcatgct
    12781 ttatcctcct tagcaaataa acctcaggtg attgttcgtt taaataaaaa taactcaaaa
    12841 aatgtcacca ttctccgcca aggcaatagt gtcagaatgc cattaacatc acaaggggaa
    12901 cgtgtacttg atgctattgc cgcagtgggc ggtgccacag aaaatctaca agatatttcc
    12961 gttcaactta cacgtggtaa agaagtaaaa atgctttcct tagaaaaatt agccactcat
    13021 cctgaagaaa acattctgct acgttcaaat gatgtcgtta cattactgaa taaacctctt
    13081 agtttcacag gattaggtgc cctcgggaca aataaacagg tgaaattctc tgcgaatggc
    13141 ttaacactcg cagaaggcat cggagaaatg ggtggactat tagataaccg tgctgatcct
    13201 aaaggggttt ttgtcttccg ttatattcca tttaataaat tatctctcgc agaacaaact
    13261 aaatggaaag ctcgtggcta tgataacgac atggagattc caacagttta tagtgtcaat
    13321 ctacttaatc caaacgcgtt gttttggtta caacgtttcc ctattcaaga taaagattta
    13381 gtttatgtat caaatgcacc aatggcagaa ttccaaaaat tcttaaaatt agtgttttct
    13441 atcacctctc ctgttacggg tacacttcat aatattaatg taattaaaaa tttataagga
    13501 tagagaatga tcgaaacaaa aatacaaaaa aatcaattta aaaaatggtc ccgaaaattt
    13561 cgaaaaataa gtacactctt taaatacatg gtaatacttc caacatgttg ctcactcttt
    13621 tattttagtt tatgggcctc tgatatttat atttctcaat cgagttttgt tgtgcgcacg
    13681 ccaaaaaatc aagccgcatt aagtggtgtc ggtgccctct tacaaagctc tggctttgct
    13741 cgcgcacaag atgatactta tactgtacaa gaattcatgc gttcacgttc tacgctagaa
    13801 ttattagaaa aaagtatccc tatccgccag ttttatgagg ataaaggtga tttatttagc
    13861 cgctttaatc ctctaaacat tttctcggaa caagaagcgt tttatcaata ctttagtaaa
    13921 aagctttctg ttaattttga ttcagtatca ggcattgcta cgctcaatat ccgggcattc
    13981 gatccgaaag aagcacaaca aattaaccaa gaattgttaa aacaaggtga atatcttatc
    14041 aatcgcctca atgaacgtgc gcgaaaagat acggttatgt ttgctgaact tgcagtcagt
    14101 gaagcagaaa aaaaagtgac agaaacttct tctgcattaa gtgaataccg tattaaaaat
    14161 ggggtattcg atttacagtc tcaatcagaa gtgcaattgt ctttaatttc gacattgcaa
    14221 aatgagctca ttacgattca aacacaatta gaccaagtac gttctatttc accaaataac
    14281 cctcaagtgc aaacattact tgcgcgagca aacagtatcc gtaaagaaat gcaacaacaa
    14341 gtacagcaag tgttaggtgg aggaaattca attgtgacac aaactgcaga atatcaacgt
    14401 ttagtactga ataatacgct cgctcagcag cagctaggta ctgcaataac gtcattacag
    14461 aatgccagat cagaggcaga tcgccaacaa ttgtatttag aaatcattag ttatcctaat
    14521 gaacccgatt tggccttaga accttaccgt ttatacaata ttcttgctac gttatttatt
    14581 tctttaattt tatatggcat tactcttctc ttattagcca gcattcgaga gcataaaaat
    14641 taatgttata cgatgaccaa actacactaa aacacgcttt tatcattcaa aatagagtga
    14701 ttggcgctct cctaatgcga gagatcatca cacgctatgg cagaaagaac ctcggttttt
    14761 tatggctatt tgttgaaccg ctcttaatga cagggctaat tgtgatcttg tggagtacct
    14821 tccgcgcaga tcaattttct aacctgaata tcatggcatt catgatcaca ggctacccgt
    14881 tgatgatgat gtggcgcaat gcatcaaata gggcgattgg tgcggtttct gccaatagta
    14941 ccctactcta tcatcgtaat gtcagagtgc ttgacacgtt aattgctagg atgatcttgg
    15001 aaatatccgg tgcaaccatt gctcaagtcg ttttaatgag tttttgtatt gcactggatt
    15061 ggatacctat gccacaggat attttctata tgctacttgc atggtttttg atggcgatat
    15121 ttgcaatcgg atttggcttt attatttgtt ctatatcgca tcatattgaa gtattcggta
    15181 aattgtgggg aatactaagc tttgcgatga tgccattatc tggcaccttc ttttttgttt
    15241 acaatctccc cccacaagcg agagaatatt tactctggat gccaatgatt catggttcag
    15301 aaatgttcag acacgggtac tttggtgatt ctgttattac actagaaaat ccttatttcc
    15361 tcattttatg tgacttaatt tttctactaa ttgggttatt aatggttgca cacttcagta
    15421 aagggataga acctcgatga tttatgtaga aaacgtctgt aaaaaatacc ttaatcgtac
    15481 ggggtggcat accgtattag acgatgtgag tttctcactt agaaaagggc aaaaagtcgg
    15541 tatcctcgga aaaaatgggg cagggaaatc aacccttatc cgtttactca gtggtgtgga
    15601 accgcctaca tcaggaaaaa ttacacgtaa aatgagcata tcttggccat taggcttcag
    15661 tggtgcattc caaggtagct taacgggtat ggataattta cgttttattg cgaggatcta
    15721 taatgcagat atcgattatg taaagcgttt tactgaagag ttctctgagc taggtaaata
    15781 cttatatgag ccagtacgga cctattcatc agggatgaaa gctcgcttag ctttcgcttt
    15841 atcactttct atcgaatttg attgttatct gattgatgaa attattgcag ttggtgatgc
    15901 acgctttgct gataagtgta aatatgagtt atttgagaaa agaaaagatc gttcattgat
    15961 cttagtttct catagcccga atgcaattcg ggaatattgt gataatgcga tggttctcca
    16021 taatggcatt atgcatcatt tcaattccat tgatattgca tatcaatttc ataataatgc
    16081 attacaaacc aaataacaaa aacccgctta tcgcgggttt ttgacgttta ttcctgagga
    16141 tattttgctg caacatcagc taatagcgtt tgtaactcac cttgttggaa catttctaaa
    16201 ataatgtcac aaccaccgac taattctcca tcaacccata attgtgggaa agttggccaa
    16261 tttgcataag ctggtaactc agcacgaata tctggatgtt gtaagatatc cacataacca
    16321 aaaggcactt tgcaatgcat aagggcttct acggcacgtg cagagaaacc gcatgatggg
    16381 aattttggtg agcctttcat gtaaataaga atagggtttt cactgatttg ttttttgatt
    16441 ttatctaagg tttccataat tttcctcaaa agtaatgaaa cggtgttatt gtagcataca
    16501 gaaaaagcgc aaccaataac ccgactaaaa taatcaacta ctcaccaact tccaccggca
    16561 ccaccaccgc caaaacttcc tccgccgaat cctccactag atccaccgcc accaaagcca
    16621 ccaaaaccac cgttaccacc cgagcggcgt cggtaacgtg gtaaagaaga tgtacgtgaa
    16681 gtcgactgat gacgacttgg actcacataa tcaccgggta agaattc
//
