LOCUS       BGC0000738             11745 bp    DNA     linear   BCT 14-JUL-2016
DEFINITION  Pasteurella multocida P1234 region 2 capsule biosynthesis gene
            cluster, partial sequence.
ACCESSION   BGC0000738
VERSION     BGC0000738
KEYWORDS    .
SOURCE      Pasteurella multocida
  ORGANISM  Pasteurella multocida
            Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
            Pasteurellaceae; Pasteurella.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:07:53
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(<1..453)
                     /gene="lipB"
     CDS             complement(<1..453)
                     /codon_start=1
                     /gene="lipB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Capsule_synth"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to Neisseria meningitidis LipB"
                     /product="LipB"
                     /protein_id="AAK17908.1"
                     /sec_met_domain="Capsule_synth (E-value: 1.3e-21, bitscore:
                     67.0, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRHNLDELIEISKNILLLQGPIGAFFMEFSLWLQQHNKTVFKLN
                     LNKGDDFFYSSKRKNTFEYTDSLDYFFDYLNAFCADNRIDSIVCFGDNRKYHQYAKKVA
                     KQLNISFWVFEEGYFRPDYVTLEKNGVNDFSTLPRDANFFLKQALHC"
     source          1..11745
                     /db_xref="taxon:747"
                     /mol_type="genomic DNA"
                     /note="Carter reference strain; type: E"
                     /organism="Pasteurella multocida"
                     /strain="P1234"
     subregion       1..11745
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000738"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..11745
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            821..1945
                     /gene="ecbA"
     CDS             821..1945
                     /codon_start=1
                     /gene="ecbA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase_2"
                     /gene_kind="biosynthetic-additional"
                     /product="UDP-N-acetylglucosamine 2-epimerase EcbA"
                     /protein_id="AAK17909.1"
                     /sec_met_domain="Epimerase_2 (E-value: 5.7e-124, bitscore:
                     403.0, seeds: 187, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFRCNNRFLVVFGTRPEAIKMAPLVEGLKKNNLNFRICVTAQHRE
                     MLDQVLELFDIIPDYDLDIMNQTQTLSTVTSSILEKIQPVIDDYKPNVIFVHGDTATTL
                     AASLAAYYNQIDIAHIEAGLRTNNIYSPWPEEGNRKLTAALAKYHFTPTQATKENLLKE
                     NIDPSKIYITGNTVIDALFLANRKIENNLTLLQKYERNFSAFLGKKIVLITGHRRENFG
                     DGFENICAAISSLAELHPDVQFVYPVHLNPNVREPVNRLLKHKKNIHLIQPLDYFSFIF
                     LMKNAYLILTDSGGIQEEAPSLGKPVLVMRKTTERPEAVQAGTVKLVGTTQELIIDSVN
                     ELLTDIEAYNKMSKAHNPYGDGRAVERTLNVFKI"
     gene            1965..3239
                     /gene="ecbB"
     CDS             1965..3239
                     /codon_start=1
                     /gene="ecbB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 419.7;
                     E-value: 2e-127)"
                     /gene_kind="biosynthetic-additional"
                     /product="UDP-N-acetyl-D-mannosaminuronic acid
                     dehydrogenase EcbB"
                     /protein_id="AAK17910.1"
                     /transl_table=11
                     /translation="MTQFNTISVIGLGYIGLPTAAVFAQHHVKVIGIDINEHTVNTINQ
                     GKIHIVEPDLEQVVQQCVNKGDLKASLIPEPADAFLIAVPTPFKGNNYEPDLSYIKSAC
                     KMISPVLKKGDLIVLESTSPVGATEKMAIWLSELRPDLTFPQQLGELSDIRIAHCPERV
                     LPGHVMRELIENDRIIGGMTPKCSQMAVDLYKIFVKGDCIVTDSRTAEMCKLTENAFRD
                     VNIAFANELSIICDKLGINVWELINLANRHPRVNILQPGCGVGGHCIAVDPWFIVNKTP
                     ELAKLIHTARLVNGSKPEWVINQVNNAVIGALQKNPNKPLQDIKIACLGLAFKPDIDDL
                     RESPALKITEKLAEKYPNQILTVEPNIEVLPNKLNGQNINLIDLNQSLKIADILVILVD
                     HKEFKTIKIENKNIRVIDTKGIFKR"
     gene            3246..5363
                     /gene="ecbJ"
     CDS             3246..5363
                     /codon_start=1
                     /gene="ecbJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /product="putative glycosyltransferase EcbJ"
                     /protein_id="AAK17912.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.2e-11,
                     bitscore: 34.4, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSNDKLIKLIEEKLIKELTEFNQTRDKLKGELNEQEKEIENIKQ
                     QLEIIDLLENKSFLPREGDTISYKLGKILLETNLFNFYRLPKRLWALNRYAKYRKSIIK
                     QENNNSISHIIEKCENKKNPAEIRKENKNEELINTGLTEKIITILSITNNQRLYMYNKI
                     APTYHLIENNIWQLNNTKANIFIIDSVWSGINNNWEYALLSDGINSIQSRKLKDVIDTI
                     KAKSIPIVFVYNEKEIHYNKFKSIMAFSDIILTSNISALDKVSVDFKDKKSCYLQKSLY
                     LEYCNPHNPLNFFEKNNVIYLGEYDKNFNDDDLDLLEPFLSLPNNELTLIHSDISHNKL
                     YDKYPGRWDIIPSNMEFTEVINKLKSFKFSLFISDTEERDIPQKIIDSLVSGVPVISTR
                     NTYLEEKFKDIILFIDSPTQLHEIVEKYENDRWAHARLAHKGYRFVMNNFSTHSLKANL
                     QREICGKAINSDNNPLISIIMASMREFYIDRIITNISRQTYKNKELIIVTQNFSEIGLK
                     KLQEKLEKIDDLVNFKIIVNNSEDTLGERQNQAASYANGSLLAKFDDDDFYFDNYLADM
                     ALPFQFGDYDMVGKAEVFFYLEALDKTVLVRDGRAAYREMDFVSGATFVIKKSTFNKLG
                     GFIEVNQSEDSNFIKRLKESGGKIYSSDPFNFVVFRSKDVSNHTWQQKAEAFANPSLHV
                     GNGIPEEITVI"
     gene            5375..6577
                     /gene="ecbK"
     CDS             5375..6577
                     /codon_start=1
                     /gene="ecbK"
                     /product="EcbK"
                     /protein_id="AAK17911.1"
                     /transl_table=11
                     /translation="MKNIKTSNIDKDAQSLAIIYTFPPYVDTSGNVFSKRIHEEIKDKI
                     TIITNKFISSPPMDDSLNELTSPYVTKRLEMQATFTYREWKYFNDFIEQAYNAYLNEIK
                     EGKIFRNLYSRSMSVITHLVAYKIKTHNPNIKWIAEFSDPILKEVDGNERNVEIPLSWL
                     EDNLSLENIKAFDNNQNLFFISELLVYLYADEIIFTNKIQKEFMLSYLKEKHFDINQNH
                     LLLKSISSRIKIKQHPTLPIEFYQKGKIKVDINKENINLGYFGNFNIKRGISEFINAWK
                     NLPKSKKTKSRLFIFTNMNSDKIYASIPEELISYIKVEKSLKYLDYLGILDSFDYVLSF
                     DTQVSKIFGLNPYLPSKISDYLGANTKTLALLEKNSPTDLISNSKLVKQYIDNINLNTL
                     F"
     gene            6592..7845
                     /gene="ecbD"
     CDS             6592..7845
                     /codon_start=1
                     /gene="ecbD"
                     /product="EcbD"
                     /protein_id="AAK17913.1"
                     /transl_table=11
                     /translation="MIEYEDFKYKFYNYDEFDSFIDYFNSIDNEDLCLIIRKTLGNRYI
                     DPSFYLNLRENIEKKSKKLKGKPKTILNLLFVYDQDSIVKDLKETYSYTSGESLISILL
                     AGRLQHYTNSIEIFYSEVKSKISSYLKNKLYQYFLSRKYSNDKLNNLFTESEKIDKYKK
                     DNIRVALCISGQVRGIETAIKSWVKAFNLNKNNNVFIDIFISTWSDAVEIKKLNWGRLG
                     DKSFSEKLKEKYKEVPEDIILDDLKKFLPPKKITEDYLLKAIGKHIHFNHIEYDIEDES
                     NYPNYTNPMKLYYKIHKCFEMTKKKGIYDLYIRIRPDLVISEVELNLIDIELELSINKN
                     ILASYAYVYEYYGFGVDDKLTISKFDNMDIYSKTWIWDKNEEREMKGHINLANNLMSHK
                     IEVRPITNIKTNFANYNI"
     gene            7874..8560
                     /gene="ecbE"
     CDS             7874..8560
                     /codon_start=1
                     /gene="ecbE"
                     /product="EcbE"
                     /protein_id="AAK17914.1"
                     /transl_table=11
                     /translation="MFIIPMAGLSSRFFKAGYNVPKYQLKIGKESVFSWSVSSFKKYFK
                     TDKFIFIYRDIYNTRSFIMSEIDKLGIDNYEIICLPSETLGQADTVYQGIKNIKVDEEI
                     YIFNIDSRISEFIKPVWTDQCDGYLEVFKGNGDHWSFALPENTTNRKVIRTAEKERISD
                     LCSNGLYFFKNKYIYEKLFINSKENNKKLKNEFYIAPLYNDLISQNGIVFYNLIEKDKT
                     FILWNT"
     gene            8593..8973
                     /gene="ecbF"
     CDS             8593..8973
                     /codon_start=1
                     /gene="ecbF"
                     /product="EcbF"
                     /protein_id="AAK17915.1"
                     /transl_table=11
                     /translation="MKRIIMDLDNTITITENGDYINSKPIKNVIEKLQQYKKLGFEIVI
                     SSSRNMRTYEGNIGKINIHTLPNIINWLNQHNVPHDEIYIGKPWCGEDGFYVDDRAIRP
                     EEFVNLTYEQIKNITKIDKDEE"
     gene            8978..10561
                     /gene="ecbG"
     CDS             8978..10561
                     /codon_start=1
                     /gene="ecbG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /product="EcbG"
                     /protein_id="AAK17916.1"
                     /sec_met_domain="APH (E-value: 5.3e-09, bitscore: 25.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIINSAAYVIPEFRNEFGLIPPSFLPIGNKKLLSFQIDALRQNF
                     PSENKIILSLPAQFTPSLDDYKLMTSLNIEPVFVEEGISLGMALLYLLNTVEYDNNDTL
                     RLLHGDTLLNTFPLEKDCIALARTQDDYAWEFESNAHNQLVWCGYFAFSSIRNFIRRLA
                     KTQGDFTSAIHQYSKEIKCVSKEIEGWLDLGHINTYFRSRAAITTQRASNDLKINNGVV
                     WKSGTPPKKIEAEANWFQNLPVNLKRFAPQLIQSGLNDNKPFYETEYLPYLPLNGIFVH
                     GENPPVFWENILGLISQYMNESQKVISITKDNLSKIHLDSISLYKDKTFERLESYSSLV
                     GINLDIPTKCDGVEQPSLRDIATECIKATLSLPEVPSIVHGDLCLSNIMYDSRGNNIKV
                     IDPRGMNTKQEFTLYGNQSYDLAKLCHSFIGLYDFIIADSFNIEKSTELGIKLTFNIDK
                     RLEEIQELFMNKKLLPNINNNEIIPATILLFLSMIPLHFDKPNRQEAMLANALRLYVAW
                     KEKTQIILNI"
     gene            10620..11600
                     /gene="ecbI"
     CDS             10620..11600
                     /codon_start=1
                     /gene="ecbI"
                     /product="EcbI"
                     /protein_id="AAK17917.1"
                     /transl_table=11
                     /translation="MKVYLISDNLTQESLNLENIEIKNSWFNLSNKKNSILFVESAWTG
                     YRKRWKYKIAAYPNNNKRTNEKLLKIISLAKDKGIPAVFWNKEDSIHFDRFINSAKYFD
                     HIFTVDQNCVERYRTVVPPETTVDVAMFPVQPRIHNYQGFNFKHMAANFIGSYSKHIHD
                     KRRERQELSFRAAFKTGLPVTVFDRNSDRKSDNYRYPTEEFCLTVRPAVDYVQTADIYR
                     QFAVSLNVNTIEDSPTMYSRRVVEVLACAGILVSTPSLAVERLFKDYCHIVNSEEEAIE
                     LFERLKYGPSSLDLEMAKAGADFVLNNFTWHHFLQKIKETIERNK"
     gene            11600..>11745
                     /gene="lipA"
     CDS             11600..>11745
                     /codon_start=1
                     /gene="lipA"
                     /note="similar to Neisseria meningitidis LipA"
                     /product="LipA"
                     /protein_id="AAK17918.1"
                     /transl_table=11
                     /translation="MFLSSLGLYKKRRYLKKFIQPAENVFFFFWGKKHVYREWVVRNIL
                     RQK"
ORIGIN
        1 acaatgaagt gcctgtttca aaaaaaaatt agcatctctc gggagcgttg aaaaatcgtt
       61 aacgccattt ttctctaacg tcacataatc cggtctaaag tagccttctt caaataccca
      121 aaaggaaata tttaattgtt tggctacttt tttagcatat tggtggtatt ttcggttatc
      181 gccaaagcaa actatcgaat caattcgatt atctgcacaa aaagcattca agtaatcaaa
      241 aaaataatct aaagaatcag tatattcaaa agtatttttt cttttcgaag aataaaaaaa
      301 atcatctccc ttatttaaat ttagtttaaa aacagtttta ttatgttgct gtaaccaaag
      361 cgaaaactcc ataaaaaaag ccccaattgg tccttgtagc aacaatatgt ttttagatat
      421 ttcaattaat tcatctaaat tatgtctaat cattcaccca ccaaataaat actaattaca
      481 attaataaaa acatttttat gacaaaggat acgacataat tcaaaaattc tcaaccaagt
      541 ataaattata aaaataaatc agaatacaat acgattaaaa aaacatctaa aacaatatta
      601 ttttttaatt tcgtgcgata tttgaacgat aaaataatag aaaacacgca attgattata
      661 tttacaatta tatcgagtgc acatattcaa taattatatt agaatgacaa ccgcttgatt
      721 ttaattagtt tatttattaa acaaaaatat gagctgttac aaaataaata cataggtaat
      781 aaatatataa actagaaaaa taagataaga agagcttcag atgtttagat gtaataaccg
      841 attcctcgtt gtttttggca ctcgtccaga ggcaatcaaa atggctcctt tagttgaagg
      901 tttgaaaaaa aataatttaa attttcgtat atgtgtaacg gctcaacata gagaaatgtt
      961 agatcaagta cttgaattat ttgatattat tcccgactat gatcttgata tcatgaatca
     1021 aacacaaaca ctctcaacag ttacctcttc gatccttgaa aaaattcaac ctgtaattga
     1081 tgattataag ccgaatgtaa ttttcgtaca tggcgataca gctacaacgt tagcggcttc
     1141 actcgcagca tattataatc aaatagatat tgcacatatt gaagctggcc ttcgtaccaa
     1201 taatatatat tccccttggc ctgaagaagg aaatcgtaaa cttactgcag cactagctaa
     1261 atatcacttt acacctactc aagcaacaaa agaaaatctt ttaaaagaaa acatagaccc
     1321 atctaaaatt tatattactg gaaatactgt aattgatgct ctttttttag caaatagaaa
     1381 aatcgaaaat aatctaacac ttttgcaaaa atatgaacgt aacttttctg cttttttagg
     1441 gaaaaaaatt gttctaatta ctggacatcg tcgagaaaat tttggtgatg gatttgaaaa
     1501 tatttgtgcg gctatttctt ctttggccga attacatcca gatgtacagt ttgtttatcc
     1561 tgttcatctg aatccaaatg taagggaacc agtaaaccgt ttattaaaac ataaaaaaaa
     1621 tattcactta atccaacctc ttgattattt ttcattcatt tttttaatga aaaatgcata
     1681 tttaatttta actgactcag gtggtattca agaagaagcc ccatccctag gaaaaccagt
     1741 tctagtaatg agaaaaacaa cagaacgccc ggaagctgtt caagcgggaa cagttaaatt
     1801 agttggtaca actcaagaac tgattattga ttcagtgaat gagttactca cggatataga
     1861 agcttataac aaaatgtcta aagcccataa tccatatgga gatggacgag ctgtagaaag
     1921 aacacttaac gtttttaaaa tttagtaata aaaaaggatg ttatatgact caatttaata
     1981 cgatttccgt cattggatta ggttacatag gtttaccaac tgccgctgtt tttgctcaac
     2041 atcatgtaaa agtaattggt attgatatta acgaacacac agtgaataca attaaccaag
     2101 gaaaaatcca catagtggag cctgatttag aacaggtagt gcagcaatgc gtaaataagg
     2161 gggatttaaa agcaagttta atccctgagc ctgcagatgc gttcttaatc gcagtaccaa
     2221 ctccttttaa gggaaataat tacgagcctg atttaagcta tatcaagtca gcctgtaaaa
     2281 tgatttctcc agttttaaaa aaaggagatc tcatcgtttt agaatcaacc tcccctgtag
     2341 gtgcaactga aaaaatggct atctggttgt ctgaactccg ccctgatttg acgtttcctc
     2401 aacaactcgg agaattatca gatatccgaa ttgcacattg tcctgaacgc gttttgcctg
     2461 gacacgtgat gagagaactc attgaaaatg atcgtattat tggtggaatg acgcctaaat
     2521 gttcacaaat ggctgttgac ttatacaaaa tctttgtaaa gggtgactgc attgtgactg
     2581 atagtcgtac agcagaaatg tgtaagctta cagaaaatgc tttccgagat gtgaatattg
     2641 cctttgcaaa tgagctatcg attatttgcg ataaattagg gataaatgtt tgggagctga
     2701 ttaacctagc taatcgacac cctcgagtca atattctaca acctggttgt ggtgttggtg
     2761 gtcattgtat tgcagtggat ccatggttta tcgtcaacaa aacaccagaa ctagccaaac
     2821 tgatccacac agcccgcttg gtaaatggta gcaagccaga atgggttatc aatcaagtaa
     2881 ataatgcggt gattggagct ttacaaaaaa atcccaataa accccttcaa gacataaaaa
     2941 ttgcctgttt aggcctagca ttcaaaccag atattgatga tttgcgtgag agtccagcac
     3001 taaaaattac cgaaaaacta gcagaaaagt acccaaatca aattttgact gtagaaccca
     3061 acatagaggt attacctaac aaattaaatg gtcagaatat taatttaata gatttaaatc
     3121 aatcattaaa aatagctgat attttagtca ttctagtaga tcataaagag tttaaaacta
     3181 taaaaataga aaataaaaat attcgagtaa tagataccaa agggattttt aaaaggtaag
     3241 aaaaaatgga ctctaatgat aaattaatta aactcattga agaaaaactt atcaaagaat
     3301 taaccgaatt caatcaaaca agagataaat taaaaggtga gttaaatgaa caagaaaaag
     3361 agatagaaaa cataaaacaa cagttagaaa taattgactt attggaaaac aaaagctttt
     3421 tacctagaga aggtgatact atatcctata aattagggaa aatcctttta gaaactaatc
     3481 tttttaattt ttacagatta ccaaaaagat tatgggctct caatagatat gccaagtatc
     3541 gtaaaagcat aattaaacaa gaaaataata attccattag tcatattata gaaaaatgtg
     3601 aaaataaaaa gaatccagct gaaattagaa aagaaaacaa gaatgaagaa ctaattaaca
     3661 ctggtctaac cgaaaaaatt attaccatac tatcgataac aaataatcaa agattataca
     3721 tgtataataa gatagctccg acatatcatc taatagaaaa taatatctgg caacttaata
     3781 atactaaagc caatattttt ataattgata gcgtatggtc tggaataaat aacaattggg
     3841 aatatgcatt attaagtgat ggaatcaata gtattcaatc aagaaagtta aaagatgtta
     3901 tagatactat taaagcaaag tctatcccta tagtttttgt atataatgaa aaagaaattc
     3961 attacaataa atttaagtca ataatggctt tttctgacat tattctaaca agcaatatat
     4021 ctgctctaga taaagtatct gttgatttta aagataaaaa atcttgctat ttacagaaat
     4081 cactttattt agaatattgc aatccacata accctttaaa tttttttgaa aagaataatg
     4141 ttatttactt aggagaatat gataaaaatt ttaatgatga tgatttagat ctattggaac
     4201 catttttatc attacctaac aatgaactaa cattaattca cagtgatatt tctcataata
     4261 aattatatga taaatatcca ggaagatggg atattatccc tagtaacatg gaatttacag
     4321 aagtaataaa taaactcaaa tccttcaaat tcagtttatt tatttcagat accgaagaaa
     4381 gagatattcc gcagaaaatt attgactctc tagtatcagg cgtacctgta atttctacaa
     4441 ggaatacata tttagaagaa aaatttaaag acatcatatt atttattgat tccccaactc
     4501 aacttcatga aattgtagaa aaatatgaaa atgatcgttg ggcacatgct cgcttagcgc
     4561 acaaaggata tcgatttgta atgaataatt tttccacaca tagtctcaaa gctaacttac
     4621 aaagagaaat atgtggcaaa gcgatcaatt cagataataa tcccttgata tcgattatta
     4681 tggcatcaat gagagaattc tatatagaca gaattattac taatatttct cgtcaaacat
     4741 ataaaaataa agagcttatc attgttactc agaatttttc agaaatagga ttaaaaaaac
     4801 tacaagaaaa attagaaaaa atagatgact tggttaattt caaaatcata gtaaataact
     4861 cagaagacac tttaggagaa agacaaaatc aagcagcaag ctatgccaat ggtagcttat
     4921 tagctaaatt tgatgatgat gatttctatt ttgacaacta tttagcggat atggctctgc
     4981 cattccaatt tggagattat gatatggttg gcaaagctga agtatttttt tacctggaag
     5041 cactagataa gacagttcta gtacgggatg gtcgagccgc ttatagagaa atggattttg
     5101 taagtggggc aacttttgtt attaaaaaat caacatttaa taaattaggt ggatttattg
     5161 aagtaaatca atcagaggat tctaatttta taaaacgtct aaaagaatct ggtgggaaaa
     5221 tttactcttc cgatcctttt aattttgttg tttttcgttc aaaagatgta tcaaatcata
     5281 cttggcagca aaaagcagag gcatttgcaa acccgtcttt acatgtagga aatggaatcc
     5341 cagaagaaat tactgttata taaggtttaa aataatgaaa aatataaaaa caagtaatat
     5401 tgataaagac gcacaatcat tggcgattat ttatactttt cctccatatg tagatacatc
     5461 tggtaatgta tttagtaaac gtatacatga agaaataaaa gataaaatca caataatcac
     5521 aaataagttt atatcttctc cacctatgga tgatagctta aacgaactaa cttcacctta
     5581 tgttactaaa agattagaaa tgcaagctac atttacctat agggagtgga aatattttaa
     5641 tgattttatt gaacaagcat ataatgctta tttaaatgag ataaaagaag gaaaaatatt
     5701 tagaaattta tacagccgtt caatgtctgt tatcacccat ttagtcgcat ataaaataaa
     5761 aactcataat ccaaatatta aatggattgc tgagttttct gacccaattc ttaaagaagt
     5821 tgatggtaat gaaagaaatg tagaaatccc attatcttgg ctagaggata atttatcatt
     5881 agaaaatatc aaagcttttg ataataacca aaatctattt tttatttccg agttacttgt
     5941 ttatttatat gctgatgaaa tcatctttac aaataagata cagaaagaat tcatgctttc
     6001 atacctgaag gaaaaacatt ttgatataaa tcaaaatcat ttattattaa aatcaatttc
     6061 atctagaata aaaataaaac aacatccaac cctgcctatt gagttctatc aaaaaggtaa
     6121 aataaaagtt gatataaata aagaaaatat aaatctagga tattttggaa attttaatat
     6181 aaagagagga atatcagaat ttataaatgc ttggaagaat cttccaaaat ctaagaaaac
     6241 aaagtcaaga ttattcatct ttacaaatat gaactcagat aagatatacg catctattcc
     6301 agaagagcta attagctaca taaaagtaga aaaaagcctt aaatatttag attatctagg
     6361 tattttggat tcatttgact atgtattatc ttttgacaca caagtatcta aaatatttgg
     6421 attaaatcca tatcttccat ccaaaataag tgattattta ggtgcaaata ctaaaacttt
     6481 agctttatta gagaaaaaca gcccaacaga cctaatatct aactcaaaat tagtaaaaca
     6541 atatatagat aatattaatc taaatactct attttaaagg gaatatataa catgattgaa
     6601 tatgaagatt ttaagtataa attttataat tatgatgagt ttgattcttt tattgattat
     6661 tttaactcaa tagacaatga agacctttgt ttaattatta gaaaaacact agggaataga
     6721 tacatagatc catcattcta tcttaacctt agggaaaaca tagaaaaaaa atccaagaaa
     6781 ctaaaaggaa aaccaaaaac tattcttaac ttactcttcg tttatgatca ggattctatt
     6841 gttaaagatc ttaaagaaac atattcatat acatccggag aaagtctaat atcaatatta
     6901 ttagcaggta gactacaaca ctatactaat tctatagaaa tattttactc tgaagtaaaa
     6961 agtaaaattt ctagctattt aaaaaataaa ctttatcaat attttttatc tagaaaatat
     7021 tctaatgata aattaaacaa cctattcaca gaatcagaaa aaattgataa atataaaaaa
     7081 gataatatta gagtagctct atgcattagc ggacaggtaa gaggaattga aacagcaata
     7141 aaaagttggg tgaaggcatt taatttaaat aaaaacaata atgttttcat agatattttt
     7201 atatccactt ggtcagatgc tgtcgagata aaaaaactaa actggggaag attaggagat
     7261 aaatcttttt ctgagaaact aaaagaaaaa tataaagaag taccagaaga tataatttta
     7321 gatgacctta aaaagttcct accaccaaag aaaataacag aagattattt acttaaggca
     7381 ataggaaaac atatacattt taaccatatt gaatacgaca tagaagatga gtcaaattat
     7441 ccaaattaca ctaacccaat gaaactttat tataaaattc ataaatgttt tgagatgaca
     7501 aagaaaaaag gaatatatga cctgtatata agaatcagac cagatctagt aatttctgaa
     7561 gtcgaactaa acctaattga tatagagctt gaactatcta taaataaaaa tatattagca
     7621 agttatgctt atgtttatga atattatgga tttggtgttg atgacaaact tactatttcc
     7681 aaatttgaca acatggatat ttattcaaaa acttggatat gggataaaaa tgaagaaaga
     7741 gaaatgaaag gtcatataaa tttagcaaat aatttaatga gtcataagat tgaagttaga
     7801 ccaataacta atataaagac aaacttcgca aattataata tatagtaaaa atcatttatt
     7861 aaaaggatat ttaatgttta ttattcctat ggcaggacta agttctaggt tttttaaagc
     7921 tggatataac gtacctaaat accaattaaa gataggaaaa gaaagtgttt tttcatggtc
     7981 cgtaagctct tttaaaaagt attttaaaac cgataaattc atttttattt atagagatat
     8041 ttataataca agatctttta taatgtcaga gatagataaa ttaggtattg ataattatga
     8101 gataatttgc ttaccatcag aaacattggg ccaagcagat accgtttatc aaggaataaa
     8161 aaatatcaaa gtagatgaag agatttacat ttttaatatt gattctcgta tttctgaatt
     8221 tataaaacct gtatggactg atcaatgcga tggttatttg gaagtattca agggaaatgg
     8281 agatcattgg tcctttgcac tcccagaaaa tactacaaac cgaaaagtaa ttcgtacagc
     8341 agaaaaagaa agaatttctg atttatgtag caatggccta tattttttta aaaataaata
     8401 tatttatgaa aaactattca taaattcaaa ggaaaataat aagaaattaa agaatgaatt
     8461 ctacattgcc ccactttata acgatttaat ttctcaaaat ggaatagtat tctataactt
     8521 gatcgaaaaa gataaaacct ttattttgtg gaacacctga agaatatgaa tttttgttag
     8581 ggaagaatta atatgaaacg tataattatg gatctagata acacaattac aataactgaa
     8641 aatggagatt atattaattc caaaccaata aaaaatgtta ttgaaaaatt acaacaatat
     8701 aaaaaattag gatttgaaat tgtaataagt tcaagccgta acatgcggac gtatgaagga
     8761 aacataggaa aaataaatat acatacattg ccaaatatta ttaattggct aaatcaacat
     8821 aacgtccctc atgatgaaat atacataggg aaaccctggt gtggagaaga tggtttttat
     8881 gtggacgatc gtgctatacg ccctgaagaa tttgtgaact taacttatga gcaaattaag
     8941 aacataacaa aaattgataa agacgaggag taaactaatg attattatta attcggcagc
     9001 ctatgttatt cccgaattcc gtaatgagtt tggtctaata cctccttcat ttttaccaat
     9061 aggtaataaa aaactgcttt cttttcagat tgatgcatta cgccaaaatt ttcctagtga
     9121 aaataaaatt atcctatcac ttcctgcaca gtttactcct agccttgatg actacaaact
     9181 gatgacttct ctcaatattg aaccagtttt tgtcgaagaa gggatatcac tgggtatggc
     9241 attattatat ttacttaata cagtagaata tgataacaat gatactctgc gtttactaca
     9301 tggagatact ctactcaata catttccttt agaaaaagat tgtatcgcat tggctcgtac
     9361 acaggatgat tatgcttggg aatttgaatc taatgctcac aaccagttag tctggtgtgg
     9421 ctattttgct ttctcctcta tcagaaattt tattcgtaga ttagctaaaa ctcagggaga
     9481 ctttacttct gccatacacc aatatagtaa agaaataaaa tgtgtgagca aagaaattga
     9541 agggtggctt gatttgggac atattaatac ttacttccgt tctcgagctg ctattactac
     9601 tcagcgagca tctaatgatc taaaaattaa taatggcgta gtttggaaat cagggactcc
     9661 tcccaaaaag atagaagcag aagcaaattg gtttcaaaac ttaccagtta atttaaaacg
     9721 cttcgctcca cagctgattc aatcaggctt aaatgataat aagccttttt acgaaacaga
     9781 atatctcccc tacttaccac taaatggaat ttttgtgcat ggagaaaatc cgcctgtctt
     9841 ttgggaaaat attttaggac taatttccca atatatgaat gaatctcaaa aagttatatc
     9901 aataactaaa gacaacctct caaaaataca tttggattca atatcacttt ataaagataa
     9961 aacttttgaa cgattagaat cttattcctc tttggttgga attaatttag acataccaac
    10021 taaatgcgat ggcgtagaac agccatcttt aagagatatc gcaacagaat gcataaaagc
    10081 aaccctatct ctaccagaag ttccctctat tgttcatgga gatttatgcc ttagcaatat
    10141 tatgtatgac tcacgtggaa ataatatcaa ggttattgat ccaagaggca tgaacactaa
    10201 acaagaattc accctttacg gtaatcaaag ctatgattta gctaaacttt gtcattcatt
    10261 tataggacta tatgacttta tcattgcaga ctctttcaat atagaaaaat caacagagct
    10321 tggaataaaa ctaactttca atatagacaa aagattagaa gaaattcaag aactctttat
    10381 gaataagaag ttattaccaa atataaataa taatgagatt attccagcta ctatcttatt
    10441 atttttatca atgattccat tgcattttga taaacctaac cgtcaagaag caatgctagc
    10501 aaatgcacta agactatatg tagcgtggaa agaaaaaacc caaatcatat taaatatata
    10561 gttgattttt ttgtcaaaaa tcccatcctc taaagtagga tttagtaaat taatataaaa
    10621 tgaaagtata tttaattagc gataatttaa cacaggagtc tttaaatcta gaaaatattg
    10681 agatcaaaaa ctcctggttt aatttaagca ataaaaaaaa ttccattcta tttgtagaat
    10741 ccgcatggac tgggtataga aaacgttgga aatataaaat agcagcttat ccaaataata
    10801 ataaaagaac aaatgaaaaa ctattaaaaa taatcagtct agctaaagat aaaggtattc
    10861 cagcagtttt ttggaataaa gaagactcca tacattttga ccgttttatt aattctgcca
    10921 aatattttga tcacattttt actgtagatc aaaactgcgt agaacgatac aggaccgtcg
    10981 taccgcctga aacaactgtt gatgtggcca tgtttccagt tcagccgcga attcataatt
    11041 atcaaggatt taatttcaag catatggcag ctaattttat cggcagttac agtaaacata
    11101 tccatgataa gcggagagaa aggcaggaat tatcatttcg tgctgctttt aaaacgggtt
    11161 taccggtaac agttttcgat agaaattcag atagaaagtc ggataattac cgttacccaa
    11221 ctgaagaatt ttgtctaacg gtacgccctg ccgtagatta cgtacaaact gccgatattt
    11281 atagacaatt tgccgtatcg cttaatgtga atacaatcga agactcacca accatgtact
    11341 ctcgtcgtgt cgttgaagtt ttagcctgcg caggcattct tgtatcaaca ccatctttag
    11401 cagtagaacg attattcaaa gattattgcc atatagtaaa ttccgaagaa gaggctattg
    11461 agttatttga acgcttaaaa tatggtccat cgtcattaga tttagaaatg gctaaagctg
    11521 gagctgattt tgtattaaat aattttactt ggcaccactt tttacaaaaa atcaaagaga
    11581 ctattgaacg taataaataa tgtttttatc aagtttaggc ttatataaaa agcgacgtta
    11641 cttaaaaaaa tttatacaac cagctgaaaa tgtttttttc tttttttggg ggaaaaagca
    11701 tgtttataga gaatgggttg taaggaatat attacgtcaa aaaat
//
