LOCUS       BGC0000773             15943 bp    DNA     linear   BCT 26-JUL-2016
DEFINITION  Escherichia coli O7-specific lipopolysaccharide biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0000773
VERSION     BGC0000773
KEYWORDS    .
SOURCE      Escherichia coli
  ORGANISM  Escherichia coli
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Enterobacteriaceae; Escherichia.
COMMENT     On or before Jul 18, 1999 this sequence version replaced L04596.1,
            U23775.1.
            Name: wbEcO7.
            ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:32:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15943
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15943
                     /db_xref="taxon:562"
                     /mol_type="genomic DNA"
                     /organism="Escherichia coli"
                     /serotype="O7:K1"
                     /strain="VW187"
     subregion       1..15943
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000773"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15943
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             22..930
                     /citation=[3]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="regulatory subunit of the UDP-glucose
                     pyrophosphorylase"
                     /gene="galF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 183.5; E-value:
                     8.2e-56)"
                     /gene_kind="biosynthetic-additional"
                     /product="GalF"
                     /protein_id="AAC63611.1"
                     /transl_table=11
                     /translation="MTNLKAVIPVAGLGMHMLPATKAIPKEMLPIPVDKPMIQYIVDEI
                     VAAGIKEILLVTHASKNAVENHFDTSYELESLLEQRVKRQLLAEVQSICPPGVTIMNVR
                     QGEPLGLGHSILCARPAIGDNPFVVVLPDVVIDDASADPLRYNLAAMIARFNETGRSQV
                     LAKRMPGDLSEYSVIQTKEPLDREGKVSRIVEFIEKPDQPQTLDSDIMAVGRYVLSADI
                     WPELERTQPGAWGRIQLTDAIAELAKKQSVDAMLMTGDSYDCGKKMGYMQAFVKYGLRN
                     LKEGAKFLKGIEKLLSEVTNS"
     gene            22..948
                     /citation=[3]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="galF"
     regulatory      928..948
                     /gene="galF"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /regulatory_class="terminator"
     regulatory      1092..1097
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /regulatory_class="minus_35_signal"
     regulatory      1115..1120
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /regulatory_class="minus_10_signal"
     stem_loop       1144..1169
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="II; site for premature transcription termination"
     stem_loop       1172..1232
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="III; site for RfaH-mediate regulation"
     misc_feature    1185..1224
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="JUMPstart"
     misc_feature    1212..1219
                     /citation=[5]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /note="ops1"
     gene            1298..2383
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="rmlB"
     CDS             1298..2383
                     /NRPS_PKS="Domain: NAD_binding_4 (4-196). E-value: 2.2e-15.
                     Score: 48.2. Matches aSDomain:
                     nrpspksdomains_rmlB_NAD_binding_4.1"
                     /citation=[2]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="dTDP-rhamnose biosynthesis"
                     /gene="rmlB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     270.6; E-value: 3.1e-82)"
                     /gene_kind="biosynthetic-additional"
                     /note="dTDP-glucose 4,6 dehydratase; formerly designated
                     RfbB"
                     /product="RmlB"
                     /protein_id="AAC63612.1"
                     /transl_table=11
                     /translation="MKILVTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLAE
                     ISDSERYSFENADICDAEGDGLYFGQHQLDAVMHLAAESHVDRSITGPAAFIETNIVGT
                     YVLLEAARNYWSGLDDEKKKNFRFHHISTDEVYGDLPHPDEVNSNETLQLFTETTAYAP
                     SSPYSASKASSDHLVRAWKRTYGLPTIVSNCSNNYGPYHFPEKLIPLVILNALEGKALP
                     IYGKGDQIRDWLYVEDHARALYTVVTEGKAGETYNIGGHNEKKNIDVVFTICDLLDEIV
                     PKEKSYREQITYVADRPGHDRRYAIDADKISRELGWKPQETFESGIRKTVEWYLANTNW
                     VENVKSGAYQSWIEQNYEGRQ"
     CDS_motif       1307..1366
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rmlB_0001"
                     /evalue="3.50E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="rmlB"
                     /protein_end="23"
                     /protein_start="3"
                     /score="13.3"
                     /tool="antismash"
                     /translation="LVTGGAGFIGSAVVRHIINN"
     aSDomain        1310..1885
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rmlB_NAD_binding_4.1"
                     /evalue="2.20E-15"
                     /label="rmlB_NAD_binding_4.1"
                     /locus_tag="rmlB"
                     /protein_end="196"
                     /protein_start="4"
                     /score="48.2"
                     /tool="antismash"
                     /translation="VTGGAGFIGSAVVRHIINNTQDSVVNVDKLTYAGNLESLAEISDS
                     ERYSFENADICDAEGDGLYFGQHQLDAVMHLAAESHVDRSITGPAAFIETNIVGTYVLL
                     EAARNYWSGLDDEKKKNFRFHHISTDEVYGDLPHPDEVNSNETLQLFTETTAYAPSSPY
                     SASKASSDHLVRAWKRTYGLPTIVSNCSN"
     gene            2383..3288
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="rmlD"
     CDS             2383..3288
                     /NRPS_PKS="Domain: NAD_binding_4 (53-159). E-value:
                     1.1e-07. Score: 23.1. Matches aSDomain:
                     nrpspksdomains_rmlD_NAD_binding_4.1"
                     /citation=[2]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="dTDP-rhamnose biosynthesis"
                     /gene="rmlD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 67.4;
                     E-value: 2.4e-20)"
                     /gene_kind="biosynthetic-additional"
                     /note="dTDP-4-keto-L-rhamnose 3,5 epimerase; formerly
                     designated RfbD"
                     /product="RmlD"
                     /protein_id="AAC63613.1"
                     /transl_table=11
                     /translation="MNILLFGKTGQVGWELQRALAPLGNLIALDVHSTDYCGDFSNPEG
                     VAETVKKIRPDVIVNAAAHTDVDKAESEPEFAQLLNATSVEAIAKAANEVGAWVIHYST
                     DYVFPGTGEIPWQGGTDATAPLNVYGETKLSSEKKALQKHCGKHIIFRTSWVYAGKGNN
                     FAKTMLRLAKEREELAVINDQFGRPTGAELLADCTAHAIRVAVDKPEVAGLYHLVAGGT
                     TTWHDYAALVFEEARKAGINLALNKLNAVPTTAYPTPARRPHNSRLNTEKFQQNFALVL
                     PDWQVGVKRMLNELFTTTAI"
     aSDomain        2542..2859
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rmlD_NAD_binding_4.1"
                     /evalue="1.10E-07"
                     /label="rmlD_NAD_binding_4.1"
                     /locus_tag="rmlD"
                     /protein_end="159"
                     /protein_start="53"
                     /score="23.1"
                     /tool="antismash"
                     /translation="RPDVIVNAAAHTDVDKAESEPEFAQLLNATSVEAIAKAANEVGAW
                     VIHYSTDYVFPGTGEIPWQGGTDATAPLNVYGETKLSSEKKALQKHCGKHIIFRTSWVY
                     AG"
     gene            3347..4228
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="rmlA"
     CDS             3347..4228
                     /citation=[2]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="dTDP-rhamnose synthesis"
                     /gene="rmlA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 294; E-value:
                     1.9e-89)"
                     /gene_kind="biosynthetic-additional"
                     /note="glucose-1-phosphate thymidylyltransferase; formerly
                     designated RfbA"
                     /product="RmlA"
                     /protein_id="AAC63614.1"
                     /transl_table=11
                     /translation="MKTRKGIILAGGSGTRLYPVTMAVSKQLLPIYDKPMIYYPLSTLM
                     LAGIRDILIISTPQDTPRFQQLLGDGSQWGLNLQYKVQPSPDGLAQAFIIGEDFIGGDD
                     CALVLGDNIFYGHDLPKLMEAAVNKESGATVFAYHVNDPERYGVVEFDNNGTAISLEEK
                     PLEPKSNYAVTGLYFYDNDVVEMARKNLKPSARGELEITDINRIYMEQGRLSVAMMGRG
                     YAWLDTGTHQSLIEASNFIATIEERQGLKVSCPEEIAYRKGFIDAEQVKVLAEPLKKNA
                     YGQYLLKMIKGY"
     gene            4233..4784
                     /citation=[2]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="rmlC"
     CDS             4233..4784
                     /citation=[2]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="dTDP-rhamnose synthesis"
                     /gene="rmlC"
                     /note="dTDP-6-deoxy-L-lyxo-4-hexulose reductase; formerly
                     designated RfbC"
                     /product="RmlC"
                     /protein_id="AAC63615.1"
                     /transl_table=11
                     /translation="MNVIKTEIPDVLIFEPKVFGDERGFFMESFNQKVFEEAVGRKVEF
                     VQDNHSKSTKGVIRGLHFQLPPYSQAKLVRCVVGEVYDVVVDIRKDSKTFGKWVRLVNL
                     SAENKRQLWIPEGFGSHGFEVISEVASFLYKTNNYYNATMEKGIRWDDEYLAINWKEKK
                     AIISEKDMKQPSFRELFEKV"
     gene            4788..6218
                     /citation=[6]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="wzx"
                     /gene_synonym="rfbX"
     CDS             4788..6218
                     /citation=[6]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="O-antigen translocase"
                     /gene="wzx"
                     /gene_synonym="rfbX"
                     /note="membrane protein"
                     /product="Wzx"
                     /protein_id="AAD44153.1"
                     /transl_table=11
                     /translation="MNNKLARQGLLWSTIERLGTQAIQLLLMLYLGRVLGPSSFGYVGM
                     LTLFLSLAQVLIDSGFSAALIRKSERTEKDYSTVFIFNICLSILIYIVLYCLSSYIALF
                     YQNTSAGIFYLIFSINRYSKWSNFNPQDSTHVDVNFKIQAKSSLIAITSSSVIAITLAA
                     LGYGVWTLVFQSLSYSVINCIVLNIYNPWYPKEKFCYETFKKLFSFSSNLLIAGVLEAF
                     YSNIYQLIIGKFFTPQLVGQFTQANQISSVPAMTLTNIIQRVTYPLFCNIYNGKGKIDD
                     AYLNTLKIAGVVVFPILLGIGLISKPLVSVLLGSEWKFTSDILFLLCIAFMIYPIHAIN
                     INILQVHGRSDLFLRLEILKKTLMTIILVITMQININAMVIGLVLHSYLSWFLNGLFSQ
                     KVSTITIRKQLKELLPIWCLCLISGLGSNYIINEISMEPLLNIIFTILLNAIIYITLIR
                     IMYKEIFMTIISLIKNKD"
     gene            6221..7336
                     /citation=[6]
                     /gene="vioA"
                     /inference="non-experimental evidence, no additional
                     details recorded"
     CDS             6221..7336
                     /NRPS_PKS="Domain: Aminotran_1_2 (37-163). E-value:
                     1.6e-08. Score: 25.9. Matches aSDomain:
                     nrpspksdomains_vioA_Aminotran_1_2.1"
                     /citation=[6]
                     /codon_start=1
                     /function="synthesis of dTDP-4-amino-4,6-dideoxyglucose
                     (dTDP-viosamine)"
                     /gene="vioA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     241.4; E-value: 2.8e-73)"
                     /gene_kind="biosynthetic-additional"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="nucleotide sugar transaminase"
                     /product="VioA"
                     /protein_id="AAD44154.1"
                     /transl_table=11
                     /translation="MNDKTIPVTQPSLPELAEFMPYLEKIWKNKWLTNNGPFHQELEEK
                     LCEFLGVQHISLFNNATIALITALQALRITGEVITTPYSFVATSHAILWNGLTPVFVDI
                     ENDGYNIDYRKIEQAITPKTSAILPVHCYSTPCEVEEIQKIADNYGLKVIYDAAHAFGV
                     NFKGGKVYLTMVIYQFLVSMRRKSSINFEGGAIISPDAKTKLRIDRLKNFGIADELTVT
                     APGINGKMSEINAAFGLVQLKHIEGSISKRKIIDSLYRNLLKGTPGITIFPGNINTNSN
                     YSYFPILIDDGFHMSRDQAYELLKKNNILSRKYFYPLISNMPMYRGLISASVDNLPIAN
                     SVADKVLCLPIYTDLNEEIVVKITKLLLGKM"
     aSDomain        6332..6709
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_vioA_Aminotran_1_2.1"
                     /evalue="1.60E-08"
                     /label="vioA_Aminotran_1_2.1"
                     /locus_tag="vioA"
                     /protein_end="163"
                     /protein_start="37"
                     /score="25.9"
                     /tool="antismash"
                     /translation="FHQELEEKLCEFLGVQHISLFNNATIALITALQALRITGEVITTP
                     YSFVATSHAILWNGLTPVFVDIENDGYNIDYRKIEQAITPKTSAILPVHCYSTPCEVEE
                     IQKIADNYGLKVIYDAAHAFGV"
     gene            7338..7916
                     /citation=[6]
                     /gene="vioB"
     CDS             7338..7916
                     /citation=[6]
                     /codon_start=1
                     /function="synthesis of dTDP-4-acetamido-4,6-dideoxyglucose
                     (dTDP-N-acetylviosamine)"
                     /gene="vioB"
                     /note="N-acetyltransferase"
                     /product="VioB"
                     /protein_id="AAD44155.1"
                     /transl_table=11
                     /translation="MAYLDEIQLKEMGFKSVGENVKISDKASFYGCDNISIGNNVRIDD
                     FCVFSAGEGGIDIHDYIHIAVYSSIIGKGKVTISDYANISSRVSIYSSNEYYSGNYMSN
                     PVVPSEYTNIHSGTVFIGKHVIIGCGSIVLPDVILHEGAAIGALSVVKEDCEAFTVNVG
                     IPAKPISERSKKLLELESVFKPSAIGDNL"
     gene            7913..8659
                     /citation=[6]
                     /gene="wbbA"
     CDS             7913..8659
                     /citation=[6]
                     /codon_start=1
                     /function="putative rhamnosyltransferase"
                     /gene="wbbA"
                     /product="WbbA"
                     /protein_id="AAD44156.1"
                     /transl_table=11
                     /translation="MKIHIYFRHTDISRTTKNNRPEWFSHENCFINLINTIKESKYKDQ
                     IAFTFIFDGSLNVASLDPLYQHFENIDMNNKKIFIINGGDQRKAWRECVKLVDEDRRVG
                     KIDKNDLIYFLENDYLHESKWIDEIFNLVKSNIRWDMATLYDHPDKYSEYCEHLDSLKN
                     KNKKTIVFYSGSRHWKIAPSTCATYIMKARVFDRTKIILKLAIYDYKLFLILTKIFRIR
                     LLSPIPALSTHCMASLLSPSINWDDL"
     gene            8659..9321
                     /citation=[6]
                     /gene="wbbB"
     CDS             8659..9321
                     /citation=[6]
                     /codon_start=1
                     /function="putative N-acetylviosaminyl transferase"
                     /gene="wbbB"
                     /product="WbbB"
                     /protein_id="AAD44157.1"
                     /transl_table=11
                     /translation="MDCKKKLCHCGLSILKPEFIINKLYNYLPDYELDGVVISNNHIVE
                     QITMKGFHIENGTNSLFEFSAYKEGIDFLEDSSLLPSGVPILILNDTLFLKHNAKFFLR
                     KIVSYYSTIQRTELPTMAGRLDPYNNICYSNSWNNMNGYISSFCMLINEKSAKIIVSCY
                     NELPKYFFSNDIDIIDPKWGMQIESRLREFIRSHLIDIDTDTVWYQAKLLHNDKQRI"
     gene            9478..10629
                     /citation=[6]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="wzy"
     CDS             9478..10629
                     /citation=[6]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="O-antigen polymerase"
                     /gene="wzy"
                     /note="formerly designated Rfc"
                     /product="Wzy"
                     /protein_id="AAD44158.1"
                     /transl_table=11
                     /translation="MRKNFYTTPITLLILTLNIAATIVVINNSELLIGDLMGFKSETVV
                     IIQSLIYISLSLLFLSVLYNGLEKIKPLTTKLADSNSRPIAIFLICLELLYITYVFNTG
                     LFVAGNNERGGGVISALFVLLNVDVLVLIFLTHVKTSKYKPIIIMLWIISFLQRGWISY
                     FFILILISFIDRRLKNKKNWKAGVVLICFILALPFVEQIKNSIRSGERISTQLTFFDYA
                     DSFNQQFMKVVGRVQTVSHVAFITDNINQLQNLKNNGESTDFFEENFIYIIAKKLGSAD
                     DKINTPDLLARYISPSLDSSWNVNPSLIGWIFIQNDLYVLPIIWVVLLCFLFTMLSKII
                     ANDLYAMNMRWLFWLVFLFPGWIFQFTAVIFSAFSIYFIKVHT"
     gene            10700..11746
                     /citation=[6]
                     /gene="wbbC"
     CDS             10700..11746
                     /citation=[6]
                     /codon_start=1
                     /function="mannosyltransferase"
                     /gene="wbbC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 108.5;
                     E-value: 7.5e-33)"
                     /gene_kind="biosynthetic-additional"
                     /product="WbbC"
                     /protein_id="AAD44159.1"
                     /transl_table=11
                     /translation="MGFGVYFRDLIAKNINEIFDGIDCEIIVVHQANIPVKELFNFPEN
                     NNITYNPVKGINGKFSRVIYEQIFMPIKFRNYNIIYSPNNINPILFGGLTKCKSIITIH
                     DLLPFRKANRFGLLQRLYLKFFTYMCAHKSEKIATVSNNSKNDIINTLNVKSDKVIVTY
                     NILGDFKKSSIHQYDCETFFFSVGALHEDKQYDLMIKAFLKFKKLVNDNCKLLIAGGDH
                     GAKKILQDLIDELKLNDHVQLLGYITDEDKWDYYENCCALILLGKYEGFGIPVLEAMSV
                     NKPSIVANTGALPEIIGKAGFVINADIDSICDAMLKSYSYKVDPKLFEDELSRFSTNKQ
                     INTLPAHV"
     gene            11761..12588
                     /citation=[1]
                     /citation=[6]
                     /gene="wbbD"
                     /gene_synonym="orf275"
     CDS             11761..12588
                     /citation=[1]
                     /citation=[6]
                     /codon_start=1
                     /function="putative galactosyltransferase"
                     /gene="wbbD"
                     /gene_synonym="orf275"
                     /note="formerly designated ORF275"
                     /product="WbbD"
                     /protein_id="AAC27537.1"
                     /transl_table=11
                     /translation="MSDDTPKFSVLMAIYIKDSPLFLSEALQSIYKNTVAPDEVIIIRD
                     GKVTSELNSVIDSWRRYLNIKDFTLEKNMGLGAALNFGLNQCMHDLVIRADSDDINRTN
                     RFECILDFMTKNGDVHILSSWVEEFEFNPGDKGIIKKVPSRNSILKYSKNRSPFNHPAV
                     AFKKCEIMRVGGYGNEYLYEDYALWLKSLANGCNGDNIQQVLVDMRFSKETAKRRGGIK
                     YAISEIKAQYHFYRANYISYQDFIINIITRIFVRLLPTSFRGYIYKKVIRRFL"
     gene            12585..14009
                     /citation=[1]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="manC"
                     /gene_synonym="formerly designated rfbM"
     CDS             12585..14009
                     /EC_number="2.7.7.13"
                     /citation=[1]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="GDP-mannose pyrophosphorylase"
                     /gene="manC"
                     /gene_synonym="formerly designated rfbM"
                     /note="formerly designated RfbM"
                     /product="ManC"
                     /protein_id="AAC27538.1"
                     /transl_table=11
                     /translation="MSSPLIPVILSGGNGTRLWPLSREEYPKQFLKLTDSISMLQSTIS
                     RLDSLNTSSPVVICNELHRFIVAEQLRHLNKLDNNIILEPSGRNTAPAICIAALILKMK
                     HPNENPLMLVLPADHSVKKVKTFCNTIKSAIPFAEAGNLVSFGIKPTHPETGYGYIQKG
                     KVLSDSDIYEVSEVRTFVEKPNLKTAESFIEKDEYYWNSGMYLFSVERYLQELSLYRPD
                     IVKVCQETVKNIHYDMDFIRLDDKIFRNCPQESIDYAVMEKTKDAVVATMDIGWNDVGA
                     WSSLWELGKKDSSGNVITGDIVCHETENSYIYTESGLVATIGIQDLVIIHTKDSLLVSR
                     RDSVQNVKNIVQHLDLSGRKEHKEHREVFKSWGRCDSIDSSEKYHYQVKRITVNPSEKL
                     SLQLHHHRAEHWVVVMGIAKLTVAEEIKILKENESVYIPAGIKHSLENIGTIPLVLIEV
                     WTGSYLADDDILRFED"
     gene            14043..15404
                     /citation=[1]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="manB"
     CDS             14043..15404
                     /EC_number="5.4.2.8"
                     /citation=[1]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="converts mannose-6-phosphate into
                     mannose-1-phosphate"
                     /gene="manB"
                     /note="phosphomannomutase; formerly designated RfbK"
                     /product="ManB"
                     /protein_id="AAC27539.1"
                     /transl_table=11
                     /translation="MLTCFKAYDIRGKLGEELNEDIAWRIGRAYGEFLKPKTIVLGGDV
                     RLTSETLKLALAKGLQDAGVDVLDIGMSGTEEIYFATFHLGVDGGIEVTASHNPMDYNG
                     MKLVREGARPISGDTGLRDVQRLAEANDFPPVDETKRGRYQQINLRDAYVDHLFGYINV
                     KNLTPLKLVINSGNGAAGPVVDAIEARFKALGAPVELIKVHNTPDGNFPNGIPNPLLPE
                     CRDDTRNAVIKHGADMGIAFDGDFDRCFLFDEKGQFIEGYYIVGLLAEAFLEKNPGAKI
                     IHDPRLSWNTVDVVTAAGTPVMSKTGHAFIKERMRKEDAIYGGEMSAHHYFRDFAYCDT
                     GMIPWLLVAELVCLKGKTLGELVRDRMAAFPASGEINSKLAHPVEAINRVEQHFSREAL
                     AVDRTDGISMTFADWRFNLRLLNTEPVVRLNVESRGDVPLMEEKTKLILELLNK"
     gene            15568..>15943
                     /citation=[1]
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /gene="gnd"
     CDS             15568..>15943
                     /EC_number="1.1.1.44"
                     /citation=[1]
                     /codon_start=1
                     /experiment="experimental evidence, no additional details
                     recorded"
                     /function="gluconate-6-phosphate dehydrogenase"
                     /gene="gnd"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1100:3-hydroxyisobutyrate dehydrogenase (Score: 112.6;
                     E-value: 4e-34)"
                     /gene_kind="biosynthetic-additional"
                     /product="Gnd"
                     /protein_id="AAC27540.1"
                     /transl_table=11
                     /translation="MSKQQIGVVGMAVMGRNLALNIESRGYTVSIFNRSREKQEEVIAE
                     NPGKKLVPYYTVKEFVESLETPRRILLMVKAGAGTDAAIDSLKPYLDKGDIIIDGGNTF
                     FQDTIRRNRELSAEGFNFYRY"
ORIGIN
        1 attttacagg tggatgaaat aatgacgaat ttaaaagcag ttattcctgt agcgggtctt
       61 gggatgcata tgttgcctgc cactaaggcg attcccaaag agatgctacc gattcccgtc
      121 gacaagccaa tgattcagta catcgttgac gagattgtgg ctgcagggat caaagaaatc
      181 ctcctggtaa ctcacgcttc caagaacgcg gtcgaaaacc acttcgacac ctcttatgaa
      241 ttagaatctc tccttgaaca gcgcgtgaag cgtcaactgc tggcggaagt acagtccatt
      301 tgcccgccgg gcgtgacaat tatgaacgtg cgtcagggcg aacctttagg tttgggccac
      361 tccattttat gtgcacgacc tgccattggt gacaatccat ttgtcgtggt gctgccagac
      421 gttgtgatcg acgacgccag cgccgacccg ctgcgctaca accttgctgc catgattgcg
      481 cgcttcaacg aaacgggccg cagccaggtg ctggcaaaac gtatgccggg tgacctctct
      541 gaatactctg tcatccagac caaagagccg ctggaccgcg aaggtaaagt cagccgcatt
      601 gttgaattca tcgaaaaacc ggatcagccg cagacgctgg actcagacat catggccgtt
      661 ggtcgctatg tgctttctgc agatatttgg ccggaacttg aacgcactca gcctggtgca
      721 tgggggcgta ttcagctgac tgatgccatc gctgaactgg cgaaaaaaca gtccgttgat
      781 gccatgctga tgacaggtga cagctacgac tgcggtaaaa aaatggggta tatgcaggca
      841 tttgtgaagt atggactacg caacctgaaa gaaggggcga agttcctgaa agggattgag
      901 aagctgttaa gcgaagtaac aaattcctga ctggaagtgt cggtcagtaa gtagagttaa
      961 aaacggcaag gtgaaggatt caatagcata agttttgctc attgaatctc actgccgttg
     1021 tcttttttat aagtacaata aaaacagcat gttagcttgc aatcatagtt caattttttc
     1081 caggattttc cttgtttcta cagctgtttg gtaagacaat tagcgtttga atttttcgga
     1141 tttggcacga gtgggttacg ctcgtcacat cgtggaaatg tacgcagtgc tctggtagct
     1201 gttaagccag gggcggtagc gtgcattaat gcatctatta atcaaatctg gagcagtcta
     1261 tttcacagca tgctctctgg ctatatggaa taaaaaagtg aagatacttg ttactggtgg
     1321 cgcaggattt attggttctg ctgttgttcg tcacataata aataatacgc aagatagtgt
     1381 tgttaatgtc gataaattaa catacgccgg aaacctggaa tcactcgctg aaatttctga
     1441 ttctgaacgt tattcatttg agaatgcaga tatctgcgat gccgaaggcg atggcttgta
     1501 ttttggacag caccagctag acgcggtgat gcacctggca gcagagagcc acgttgaccg
     1561 ctcaataact gggcctgcgg catttattga aaccaatatt gtgggtactt atgttctttt
     1621 agaagcggcg cgcaattatt ggtctggtct ggatgatgaa aagaaaaaaa acttccgttt
     1681 tcatcatatt tctactgatg aggtgtatgg tgacttaccc catccggatg aagtaaatag
     1741 caatgaaacg ttgcagctat ttacggaaac gacagcatac gcgccaagta gtccatattc
     1801 tgcttctaaa gcttccagcg atcatttggt tcgcgcatgg aaacgtactt atggtttacc
     1861 gaccattgtg tctaattgct cgaacaacta tggtccttat catttcccgg aaaagcttat
     1921 tccactggtt attcttaatg cactggaagg taaggcatta cctatttatg gcaaaggaga
     1981 tcagatccgc gactggttgt atgtagagga tcatgctcga gcgttatata ccgtcgtaac
     2041 cgaaggtaaa gcgggcgaaa cttataacat tggtggacac aacgaaaaga aaaacatcga
     2101 cgtagtgttc actatttgtg atttgttgga tgagatagtc ccgaaagaga aatcttatcg
     2161 tgagcaaatt acctatgttg ctgatcgccc agggcatgat cgccgttatg caattgatgc
     2221 cgataaaatt agccgcgaat tgggctggaa accgcaagaa acgtttgaga gcggtattcg
     2281 taaaacggtg gaatggtatc tggctaatac aaattgggtt gagaatgtga aaagcggtgc
     2341 ttatcagtcg tggattgaac agaactatga gggccgccag taatgaatat cctcctattc
     2401 ggcaaaacag ggcaggtagg ttgggaactg cagcgtgctc tggcaccgct gggtaatctg
     2461 attgctcttg atgttcactc cactgattat tgtggtgatt ttagtaatcc cgaaggtgta
     2521 gctgaaactg tcaaaaaaat tcgccctgat gttattgtta atgcggctgc tcacactgac
     2581 gtagacaaag cggaatcaga accggaattt gcacaattac ttaacgcgac aagtgtcgaa
     2641 gcgattgcaa aagcagccaa tgaagtcggt gcttgggtta ttcactactc tactgactac
     2701 gtatttccgg gaaccggtga aataccgtgg cagggaggaa cggatgctac agcacctttg
     2761 aatgtttatg gtgaaactaa acttagctcc gagaaaaaag cgttacagaa acattgcggc
     2821 aagcatatta ttttccgtac cagctgggta tatgcaggta aaggaaataa cttcgccaaa
     2881 acaatgttgc gtctggcaaa agagcgcgaa gaactggctg tgataaacga tcagtttggc
     2941 cgaccaacag gtgccgaatt gctggctgat tgcaccgctc atgccattcg cgtagcagta
     3001 gacaaaccag aagttgctgg tttgtaccat ctggttgctg gcggtacaac aacctggcac
     3061 gattatgccg ctctggtatt tgaagaagcg cgcaaagcag ggattaacct tgctcttaac
     3121 aaacttaacg ccgtgccaac aacggcctat cccacaccag cccgtcgacc ccataactct
     3181 cgcctcaata cagaaaagtt tcagcagaac tttgcgcttg tcttgcctga ctggcaggtg
     3241 ggtgtgaaac gaatgctcaa cgaattattt acgactacgg caatttaaca aatttttgca
     3301 tctcgctcat gatgccagag cgggatgaat taaaaggaat ggtgaaatga aaacgcgtaa
     3361 aggtattatt ctggctggtg gttccggcac tcgtctttat cctgtgacga tggcagtaag
     3421 taaacaactg ctgccgattt atgataagcc gatgatttat tatccgcttt caacgcttat
     3481 gttagcgggt attcgcgata ttcttattat cagtacgcca caggatacgc cgcgtttcca
     3541 acaattgttg ggggacggga gccagtgggg gcttaatcta cagtataaag tacaaccgag
     3601 tccggatggc ctggcgcaag cgtttatcat tggtgaagac tttattggtg gcgatgattg
     3661 tgcacttgtg cttggtgata atatcttcta tggacacgac ttgccgaaat taatggaagc
     3721 tgctgttaac aaagaaagcg gtgcaacggt atttgcttat cacgttaatg atcctgaacg
     3781 ttatggtgtc gtggagtttg ataataacgg tactgcaatt agcctggaag aaaaaccgct
     3841 ggaaccaaaa agtaactatg cggttactgg gctttatttc tatgacaatg acgttgtgga
     3901 aatggcccgg aaaaacctta agccttctgc ccgaggtgaa ctggaaatta ccgatattaa
     3961 ccgtatttat atggaacaag gacgtttgtc tgtcgctatg atggggcgtg gctatgcatg
     4021 gctggataca gggacgcatc aaagtcttat tgaagcaagc aacttcattg ccaccattga
     4081 agagcgccag ggactaaagg tttcctgtcc ggaagaaatt gcttatcgta aagggtttat
     4141 tgatgctgag caggtaaaag tattagccga accgttgaag aaaaatgctt atggtcagta
     4201 tctgctcaaa atgattaaag gttattaata agatgaacgt aattaaaact gaaattcctg
     4261 atgtattaat atttgaacca aaagtatttg gggatgagcg tggttttttt atggaaagct
     4321 tcaatcagaa agttttcgaa gaagctgtgg ggcggaaggt tgaatttgtt caggataacc
     4381 attctaagtc tactaaagga gtaattagag gattacattt tcaattacca ccttattcac
     4441 aggcaaaatt agtacgctgt gtagtaggtg aggtatatga cgttgttgtt gatataagga
     4501 aagattctaa aacttttggc aaatgggtcc ggcttgtaaa tctttctgct gaaaacaaac
     4561 gacagttgtg gattccagaa ggattcggtt cccatggttt tgaagtgatt agtgaagttg
     4621 cttctttttt atacaaaaca aataattatt ataatgcaac tatggaaaaa ggtataagat
     4681 gggatgatga atatttagct attaattgga aagaaaaaaa agcgataatc tctgagaaag
     4741 acatgaaaca accatcattc agagaacttt ttgagaaagt ttaattgatg aataacaaac
     4801 tagccaggca aggattatta tggagcacaa ttgaaaggct aggaacgcaa gccatacaat
     4861 tattattaat gttgtatttg ggtagggttc ttggaccaag ctcttttggt tatgttggta
     4921 tgctaacttt atttctatca ttagctcagg ttctaattga tagtggattt agtgcagcat
     4981 taattagaaa atcggagcgt actgaaaaag attattcgac agtatttata tttaatattt
     5041 gtctatcaat actaatatat attgtacttt attgtttatc ttcttatatt gctttattct
     5101 atcaaaatac ctctgctgga atcttttact tgatatttag cattaacaga tatagcaaat
     5161 ggtctaactt taatccccaa gattcaactc acgtagacgt gaattttaag atccaagcta
     5221 aaagttcact tatcgctatt accagtagta gtgtaatagc gataacgtta gctgctttgg
     5281 gttatggagt atggacattg gttttccaat cgttatccta tagtgtcata aattgtattg
     5341 tactgaatat ttataatcca tggtatccaa aagagaaatt ttgctatgaa acattcaaaa
     5401 agctattttc atttagcagt aacttactaa ttgctggagt acttgaagct ttttattcaa
     5461 atatatatca attaattata gggaaatttt ttacaccaca gcttgtaggg caatttacac
     5521 aggctaatca gatctctagc gtacctgcaa tgacacttac taatattatt cagagagtaa
     5581 cttatccact tttttgtaat atttataatg gcaaagggaa aatagatgat gcttatttaa
     5641 acacacttaa aattgcaggc gttgtagttt ttccaattct attaggaata ggtttaatct
     5701 cgaagccatt agtctctgta ttattaggaa gtgagtggaa atttacatct gatattctgt
     5761 ttctactttg tattgcattt atgatttatc ctatacatgc aataaatatt aatatcctac
     5821 aggttcatgg gcgaagtgat ctttttttgc gtttggaaat actaaaaaag acattgatga
     5881 caattattct tgtcattacg atgcaaataa atataaatgc aatggtgatt ggtttagttt
     5941 tacactcata tctttcgtgg tttttaaatg gattatttag ccagaaagta tcaacgatca
     6001 caataaggaa gcagttaaaa gagttactac ctatatggtg tctatgttta attagtgggt
     6061 taggttctaa ctatattata aatgaaataa gtatggaacc tttattaaat ataatattta
     6121 ctattttatt aaatgccatt atatacatca cactaattcg aattatgtac aaagaaatat
     6181 ttatgactat tatttctctt ataaaaaata aggactgaaa atgaacgata aaactattcc
     6241 agtaacgcaa ccttctttgc cggaacttgc agaattcatg ccttacctgg aaaaaatatg
     6301 gaaaaataaa tggttgacaa ataatggacc atttcatcaa gaactcgagg aaaaattatg
     6361 tgaatttttg ggtgtgcagc atatctcgct ttttaacaat gcaacaattg cattgatcac
     6421 agcattacaa gccctaagaa taacaggtga ggtaataaca acaccatatt catttgttgc
     6481 aacttcacat gctattttat ggaatggact tacgcctgtc tttgttgata ttgaaaatga
     6541 tggatataat attgattaca gaaaaataga acaggctatt acaccaaaaa cttcagcaat
     6601 tttacctgtc cattgctact caacaccctg tgaagtcgaa gaaattcaaa aaatagctga
     6661 taattatgga ttgaaagtaa tctacgacgc agcacatgca ttcggtgtaa attttaaagg
     6721 gggcaaagtt tacttaacta tggtgattta tcaattctta gtttccatgc gacgaaagtc
     6781 ttcaataaac tttgaaggtg gggcaataat tagccctgat gctaaaacca agttacgtat
     6841 agatcgatta aaaaactttg gtatcgccga cgagctgact gtgacagctc caggaataaa
     6901 tggcaaaatg agtgaaatta atgctgcctt tggacttgtt cagttaaagc atattgaggg
     6961 ctcaatatct aagcgaaaaa taattgatag tctttaccgg aatttactga aagggactcc
     7021 gggtattact atatttccag gaaatataaa tacaaatagc aactattcat attttcctat
     7081 actcatagat gatggttttc atatgagtcg tgatcaggca tatgaattac ttaagaaaaa
     7141 taatatccta tctcgaaagt atttttatcc attaatcagt aatatgccta tgtatcgagg
     7201 attgatttca gctagcgttg ataatctacc aatagccaat agtgttgctg ataaagtcct
     7261 atgcttgcca atatatacag atttaaatga agagattgtt gtgaaaataa ccaaattatt
     7321 attgggtaag atgtgatatg gcctatttag atgaaataca gttaaaagaa atgggcttca
     7381 aaagcgttgg agaaaatgta aaaatatcag ataaggcatc tttttatggg tgtgataata
     7441 ttagtattgg gaataatgta aggattgatg atttttgcgt gttttcagct ggagagggtg
     7501 gtattgatat acacgattat attcatatag cggtatattc ttcaattatt ggcaaaggaa
     7561 aagtaactat atctgactac gcaaacattt catctcgagt ctcaatatat tccagtaacg
     7621 agtattattc tggcaattat atgtctaatc cagtagttcc aagtgaatat acgaatatac
     7681 atagcggtac tgtatttata ggcaaacatg ttatcatagg ttgcggaagt attgttcttc
     7741 cggatgttat tttacatgag ggtgcagcaa ttggagctct ttctgtagtc aaagaggatt
     7801 gtgaagcttt tacggtaaat gtaggtatac cagctaaacc aatatctgaa agaagcaaga
     7861 aattattgga gcttgaatct gtatttaaac caagcgctat tggagataat ctgtgaagat
     7921 tcatatttat tttcggcata cggatattag tcggacaact aaaaataatc ggcctgagtg
     7981 gtttagtcat gaaaattgtt ttataaatct tataaataca ataaaagaat ctaaatataa
     8041 agaccaaata gcatttactt ttatttttga tggatcatta aacgttgctt ccttagatcc
     8101 gttatatcaa cactttgaaa atatcgatat gaataataaa aagatattca taatcaatgg
     8161 aggagatcag cgcaaagcat ggcgtgaatg cgtaaaacta gtagatgaag atcgtcgagt
     8221 tggaaaaatt gataaaaatg atttaatata ttttttagaa aatgattatt tgcatgagtc
     8281 taaatggatt gatgagatat ttaacttggt caaatcaaat ataagatggg atatggcaac
     8341 gctttatgat catccagata aatatagtga atattgtgaa catcttgatt cattaaaaaa
     8401 taaaaacaaa aaaactattg tattttattc tgggagtagg cattggaaaa tagcaccaag
     8461 tacatgtgca acatatatta tgaaagccag ggtttttgat aggacaaaaa taattctaaa
     8521 attagctatt tacgattaca aattattttt gatacttact aaaatattta gaattagact
     8581 tctttcacct atccccgctc tttcaactca ttgtatggct tctttgttat caccttcaat
     8641 caattgggat gatttataat ggattgtaaa aaaaaattat gccattgtgg cctgtctata
     8701 cttaagccag aattcataat taataaatta tataattatt taccagatta tgaactagat
     8761 ggtgttgtga tttccaataa tcatatagta gaacagatta caatgaaggg atttcatatc
     8821 gaaaacggga caaattctct ttttgagttt tctgcctata aggaaggaat agatttttta
     8881 gaagatagct cattattacc atcaggagta ccaattctca ttttgaatga tacattgttc
     8941 ttgaaacata atgcaaaatt ctttttaagg aaaattgtga gttattattc aacaattcaa
     9001 agaactgaat tgcctacaat ggcaggtcgt ttagatcctt ataataatat atgttacagt
     9061 aactcttgga ataatatgaa tggctatata tcttcctttt gtatgctaat aaatgaaaaa
     9121 tctgcaaaaa taattgttag ttgctacaat gagcttccaa aatatttttt tagtaatgat
     9181 attgatatta ttgaccccaa atggggaatg cagattgaat caagactgag agaatttatt
     9241 cgtagtcatt taattgatat agacacagat acggtttggt atcaagctaa attgttacat
     9301 aatgataaac aacgaattta atatttaaag ctcaatgtgt cttcatggaa catttcatat
     9361 cagggaagat tggtgaaagt ggaattgttg tttctatttt ttcccacatg gaaaggaaag
     9421 ggtgttaaat tttttaaacg agcaattggc taaaatcaag aggaagatta taattaaatg
     9481 agaaaaaatt tttacacgac accaatcaca ttactaattc ttacgcttaa tattgctgca
     9541 acaattgtag ttataaacaa cagtgaatta ttgattggcg atttaatggg gtttaaatca
     9601 gaaactgtcg taataattca atctctaatt tatatatctc ttagcttatt atttctatcg
     9661 gtattatata atggattgga aaaaataaaa ccacttacaa caaaattagc tgattctaat
     9721 agtagaccga tcgccatttt tttaatttgt ttagaattat tatatataac atacgtattt
     9781 aatacaggct tatttgttgc tggtaataat gagcgcggag gcggagtaat ttcagcgtta
     9841 tttgtattac tgaatgttga tgtacttgtt ttaatatttc taacacatgt taaaacaagt
     9901 aagtacaagc ccattattat catgttgtgg attatttctt ttcttcagcg tggttggata
     9961 tcttattttt tcattttgat tttaatctca tttatcgatc gtcgattgaa aaacaaaaaa
    10021 aattggaaag ctggggtagt attaatatgt tttattctgg ctctgccatt tgtagaacag
    10081 attaagaatt ctatcagaag tggcgaacgt atcagcacgc aattaacttt ttttgattat
    10141 gcggattctt ttaatcaaca atttatgaag gttgttggca gagttcaaac agtttcacac
    10201 gttgcattta taacagataa tattaatcaa cttcagaatt taaaaaataa tggagaatct
    10261 actgattttt ttgaagaaaa ttttatttat ataattgcta aaaaattagg gagtgctgat
    10321 gataagatta atactccaga tttgcttgcc agatatattt ctccatctct ggatagctca
    10381 tggaatgtga atccatcgtt aattggttgg atttttattc aaaatgattt atacgttcta
    10441 cccatcatat gggttgtttt gctgtgtttt ctatttacaa tgctatctaa aattattgcg
    10501 aatgacctat atgcaatgaa tatgagatgg ttgttttggt tagtgttttt atttccgggt
    10561 tggatattcc aattcacagc agttatattt tcggctttta gtatttattt tattaaagta
    10621 cacacttagg actaaaagag taaaccttta tgacgaaaat agttttcaat ttactatctt
    10681 tttgcagaat taaaatatta tggggtttgg agtatacttt agagatttaa ttgcaaaaaa
    10741 tattaatgaa atattcgatg ggattgattg cgaaataata gttgttcacc aggctaatat
    10801 ccctgttaaa gaattgttca attttccaga aaacaataat attacctata atcctgtaaa
    10861 aggcattaat gggaaatttt cgcgtgttat ttacgaacag atatttatgc cgattaaatt
    10921 tcgtaactat aacataattt attccccaaa taatattaat ccgattcttt ttgggggtct
    10981 aactaaatgt aagtcaataa ttactattca tgacttgctt ccatttagaa aggctaatag
    11041 atttggtctt ctacaaagat tgtatctaaa gtttttcaca tatatgtgtg ctcacaaatc
    11101 ggaaaaaatc gctacagtgt ccaataattc aaaaaatgat attatcaata cccttaatgt
    11161 caagagcgat aaggttattg taacttacaa tatattaggt gattttaaaa aatcctctat
    11221 acaccaatat gattgtgaaa cctttttttt ctcggtgggt gctttgcatg aagataaaca
    11281 atacgatttg atgataaagg cttttctaaa gttcaaaaaa ttagtcaatg ataattgtaa
    11341 attattaatt gctgggggtg atcatggagc taagaaaatt ttacaggact tgattgatga
    11401 attaaaatta aatgaccatg ttcaattatt aggatatatc actgatgaag ataagtggga
    11461 ctactatgaa aattgttgtg cacttatctt actagggaaa tatgaaggtt ttggtattcc
    11521 tgtattggaa gctatgagtg tcaataagcc atcaattgta gcaaataccg gggctctacc
    11581 tgagatcata ggtaaagcag gatttgtcat aaatgctgat attgattcaa tttgtgatgc
    11641 tatgttaaaa agctattcat ataaagttga cccaaaattg tttgaagatg aattatcacg
    11701 cttttctact aataaacaaa taaatacttt gccagcacat gtttaaggaa atatgtaaag
    11761 atgtcagatg acactccaaa gttttctgtt ttgatggcta tatacatcaa ggattctccc
    11821 ctatttctct ctgaggcttt acaatcaatt tataaaaata cggttgcccc agatgaagtt
    11881 attattattc gtgatggtaa ggtcacatct gaactcaatt ctgttattga tagttggaga
    11941 agatatttaa atataaaaga tttcacactt gaaaaaaata tggggttggg ggcagcgtta
    12001 aattttgggt tgaatcaatg tatgcatgat ttagtaatac gtgctgattc tgatgatata
    12061 aatagaacaa atcgattcga atgtatactt gattttatga ctaagaatgg tgatgttcat
    12121 attcttagct cttgggttga agagttcgaa ttcaatccag gagataaggg cataataaaa
    12181 aaagtaccaa gtcggaattc tatacttaaa tattcaaaaa acagatctcc ttttaatcac
    12241 cctgcagttg catttaaaaa gtgtgaaata atgcgcgtcg gcggttatgg aaatgagtac
    12301 ttatatgaag attatgccct ttggttgaaa tctttagcta atggatgtaa tggtgataat
    12361 attcaacaag ttttagttga tatgagattt tcaaaggaaa cagcaaaaag acgaggtgga
    12421 ataaaatatg ccatttcaga aattaaagct cagtatcatt tttatcgtgc aaattatata
    12481 tcatatcaag actttataat aaatattatc acaaggatat ttgttagact tcttcccact
    12541 agttttcgtg gctatatata taaaaaagtt atcaggagat ttttatgagc tcacctctta
    12601 ttccggttat attaagtggt ggtaatggta ctaggttatg gccactatct agagaggaat
    12661 atcctaagca gtttttaaaa ctaaccgact caatatcaat gctgcaatca acaatatctc
    12721 ggttagactc attaaatact tcctctccag ttgtaatatg caatgaatta cacagattta
    12781 ttgttgcaga acaactcagg cacttaaata aattagataa taatattatt ttagaaccat
    12841 ctggtcgcaa tactgcacct gctatttgta ttgctgcttt aattttaaaa atgaagcatc
    12901 caaatgaaaa tccacttatg ctcgttcttc cagccgatca ctccgtaaaa aaagtcaaaa
    12961 ctttttgtaa tacaataaaa agtgctattc ccttcgctga agctggtaat ttggtttctt
    13021 ttggtattaa acctactcat cctgagacgg ggtatggata tatacaaaaa ggcaaagtgt
    13081 tatctgattc tgatatatat gaggtcagtg aagttagaac ttttgttgaa aagcctaatc
    13141 ttaaaacagc agaaagcttt atagaaaaag atgagtatta ttggaatagt ggtatgtatt
    13201 tgttcagtgt tgaacgttac ttacaagagt tatcattata ccgaccagac atagttaaag
    13261 tatgccagga aactgttaaa aatattcatt atgatatgga ttttattaga ttggacgata
    13321 aaatatttcg gaactgtcca caggagtcta ttgattatgc tgtaatggag aaaacaaagg
    13381 atgctgtagt tgctacaatg gatatcggtt ggaatgatgt aggagcatgg tcttcgcttt
    13441 gggaattagg gaaaaaagac tcctctggta atgttatcac gggagacatc gtttgccacg
    13501 agacagaaaa tagttatatt tatactgagt ctggattggt agcaactatt ggtattcaag
    13561 atcttgttat tattcatact aaagattcat tactggtttc cagacgcgat tcagtacaaa
    13621 atgtaaaaaa tattgttcag catcttgatt tgtcaggacg taaagaacat aaagaacata
    13681 gggaagtatt caagtcatgg ggacgatgtg actccataga tagtagcgaa aagtaccact
    13741 atcaggtcaa acgaataaca gttaatccaa gtgaaaaatt atcgttgcaa ttacatcatc
    13801 accgtgcgga acattgggtt gttgtaatgg ggattgctaa acttacagtt gcagaagaaa
    13861 taaaaatttt aaaagagaat gagtctgtat atattcctgc aggtattaag catagtttgg
    13921 aaaatattgg gacaatacca cttgtgttaa tagaagtttg gaccggttct tatcttgctg
    13981 atgatgatat ccttcgattt gaagattgat atggtagagc ttagaaatag agagtcttaa
    14041 taatgctaac ttgctttaaa gcttatgata ttcgcgggaa actaggcgaa gaactgaatg
    14101 aagatatcgc ctggcgcatt gggcgtgcct atggcgaatt tctcaaaccg aaaaccattg
    14161 tgttaggcgg tgatgtccgc ctcaccagcg aaaccttaaa actggcgctg gcgaaaggtt
    14221 tacaggatgc gggcgtcgat gtgctggata tcggtatgtc cggcaccgaa gagatctatt
    14281 tcgccacgtt ccatctcggc gtggatggtg gcattgaagt taccgccagc cataatccga
    14341 tggattataa cggcatgaaa ctcgtgcgcg agggggctcg cccgatcagc ggggataccg
    14401 gactgcgcga tgtccagcgt ctggcagaag ccaacgactt ccctcccgtt gatgaaacca
    14461 aacgcggtcg ttatcagcaa atcaatctgc gtgacgctta cgttgatcac ctgttcggtt
    14521 atatcaacgt caaaaacctc acgccgctca agctggtgat taactccggg aatggcgcgg
    14581 cggggccggt ggtggacgcc attgaagccc gctttaaagc cctcggcgca ccggtggaat
    14641 taatcaaagt acacaacacg ccggacggca atttccccaa cggtattcct aacccgttgc
    14701 tgccggaatg ccgcgacgac acccgtaatg cggtcatcaa acacggcgcg gatatgggca
    14761 ttgcctttga tggcgatttt gaccgctgtt tcctgtttga cgaaaaaggg cagtttatcg
    14821 agggctacta cattgtcggc ctgctggcag aagcattcct cgaaaaaaat cccggcgcga
    14881 agatcatcca cgatccgcgt ctctcctgga acaccgttga tgtggtgacc gccgcgggca
    14941 ccccggtaat gtcgaaaacc ggacacgcct ttattaaaga acgtatgcgc aaggaagacg
    15001 ccatctacgg tggcgaaatg agcgcccacc actatttccg tgatttcgct tactgcgaca
    15061 cgggcatgat cccgtggctg ctggtggccg aactggtgtg tctgaaagga aaaacgctgg
    15121 gcgaactggt gcgcgaccgg atggcggcgt ttccggcaag cggtgagatc aacagcaaac
    15181 tggcgcaccc cgttgaggcg attaatcgcg tcgaacagca ttttagccgc gaggcgctgg
    15241 cggtggatcg caccgatggc atcagcatga cctttgccga ctggcgcttt aacctgcggc
    15301 tcctcaacac cgaaccggtg gtgcggttga atgtggaatc gcgcggtgat gtaccgctga
    15361 tggaagaaaa gacaaaactt atccttgagt tactgaacaa gtaattcagt aatttcatat
    15421 aaatggtttt taaaaaacgg aaaagatgag atatccggtg tggtatagcc aaggtaatgc
    15481 tattcagtat ctctatgagt gagttaacat ctataccaca tttaagccgc acacttcgcg
    15541 gtgaccaccc cctgacagga gtaaacaatg tcaaagcaac agatcggcgt cgtcggtatg
    15601 gcagtgatgg ggcgcaacct cgcgctcaac atcgaaagtc gtggttatac cgtctctatt
    15661 ttcaaccgtt cccgtgaaaa gcaggaagaa gtgattgccg aaaatccagg caagaaactg
    15721 gttccttact atacggtgaa agagtttgtt gaatctctgg aaacgcctcg tcgcatcctg
    15781 ttaatggtga aagcaggtgc aggcacggat gctgctattg attccctcaa gccatacctc
    15841 gataaaggtg acatcatcat tgatggtggt aataccttct tccaggacac cattcgtcgt
    15901 aaccgtgagc tttctgccga aggctttaat ttttatcggt acc
//
