LOCUS       BGC0000778             10545 bp    DNA     linear   BCT 17-APR-2008
DEFINITION  Aeromonas hydrophila strain AH-3 HldD (hldD), WahA (wahA), WaaL
            (waaL), WahB (wahB), WahC (wahC), WahD (wahD), and WahE (wahE)
            genes, complete cds.
ACCESSION   BGC0000778
VERSION     BGC0000778
KEYWORDS    .
SOURCE      Aeromonas piscicola
  ORGANISM  Aeromonas piscicola
            Bacteria; Pseudomonadota; Gammaproteobacteria; Aeromonadales;
            Aeromonadaceae; Aeromonas.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 14:11:26
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10545
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10545
                     /db_xref="taxon:600645"
                     /mol_type="genomic DNA"
                     /organism="Aeromonas piscicola"
                     /serotype="O34"
                     /strain="AH-3"
     subregion       1..10545
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="saccharide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10545
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            591..1550
                     /gene="hldD"
     CDS             591..1550
                     /NRPS_PKS="Domain: NAD_binding_4 (62-192). E-value:
                     2.8e-07. Score: 21.7. Matches aSDomain:
                     nrpspksdomains_hldD_NAD_binding_4.1"
                     /codon_start=1
                     /gene="hldD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     169.9; E-value: 1.5e-51)"
                     /gene_kind="biosynthetic-additional"
                     /note="ADP-L-glycero-D-manno-heptose 6-epimerase"
                     /product="HldD"
                     /protein_id="ACA14473.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1e-12, bitscore:
                     36.6, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVVTGGAGFIGSNLVKQLNAQGRTDIVVIDDLTDGTKFVNLVDL
                     TIADYMDKDEFQARIVSGDEFEEWDDGIEVIFHEGACSATTEWNGKFIMEVNYEYSKDL
                     FHYCIEREIPFIYASSAATYGGRNDNFIEDPKFEQPLNVYGYSKQLFDQYVRRWMPEIN
                     SQVVGLKYFNVYGPREQHKGSMASVAFHLNTQVKKGENPKLFEGCDGFPNGGQMRDFIY
                     VDDVCKVNLWFWQNPQHSGIFNCGTGRAEPFQNVAEAVIQHHQKGAIEYIPFPDHLKGR
                     YQSFTQADMTRLRGVGYDAEFKTVAEGVADYMAWLNRV"
     aSDomain        777..1166
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_hldD_NAD_binding_4.1"
                     /evalue="2.80E-07"
                     /label="hldD_NAD_binding_4.1"
                     /locus_tag="hldD"
                     /protein_end="192"
                     /protein_start="62"
                     /score="21.7"
                     /tool="antismash"
                     /translation="GDEFEEWDDGIEVIFHEGACSATTEWNGKFIMEVNYEYSKDLFHY
                     CIEREIPFIYASSAATYGGRNDNFIEDPKFEQPLNVYGYSKQLFDQYVRRWMPEINSQV
                     VGLKYFNVYGPREQHKGSMASVAFHL"
     gene            1601..3361
                     /gene="wahA"
     CDS             1601..3361
                     /codon_start=1
                     /gene="wahA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 61.2;
                     E-value: 1.7e-18)"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyltransferase"
                     /product="WahA"
                     /protein_id="ACA14474.1"
                     /transl_table=11
                     /translation="MNILMALSQLEVTGAEVYATTVGNELTRRGHQVFYVSDTLTKPTQ
                     GPVFKLRFNKRSILRRFWHVFYLIYLIKKHHIQLVHAHSRASGWSSYVACKLTGTPMVT
                     TVHGRQPVHASRKAFHALGFRAVAVCEDIAHQIIDNLGVDPAIVQVLRNGIETDKFQPV
                     PAPDNATPVIAIIGRLSGPKGELCYRLLDEVLDLDACQVRVVSGSQLPERFHRFQSQVD
                     FVGYVDDVPTLLAGCDLVIGAGRVAMEALLCGRPAFAIGEAKAIGLVTEQNLAEALASN
                     FGDIGPQDLAIDFSALKTEIAPALASKSVPEAIRQRIQDEYGLEKVVSGLESIYQDAVV
                     ETLRREMPVIMYHRFIEHDSEKGVHGTWMPIAMFEKHLRLMKWLGYETLTFRDLADRGF
                     IHRLEYGKKYLMITADDGYQDNLTRMLPLLEKYGYKAVVYVVTGEAHNRWDVEHATNPD
                     TQVSLMNGEQIKALVASGHVEVGGHTLTHPRLSELSPERQVHEIRENKRQLEALLGHSL
                     LSFAYPYGDMDESAKVQAQAAGYRFAVATNSGPRAMHQDPYRIRRIAIFPRTDVFGLWR
                     KIRGNYVFRK"
     gene            3368..4579
                     /gene="waaL"
     CDS             3368..4579
                     /codon_start=1
                     /gene="waaL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /note="lipid A core-O-antigen ligase"
                     /product="WaaL"
                     /protein_id="ACA14475.1"
                     /sec_met_domain="Wzy_C (E-value: 3.3e-19, bitscore: 58.4,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIRCLYLLDKTTTALFALTIIFSFCGLFLVPAGQSIESNLLAVT
                     GIFGLLNYFVGKQQDVGLKDRRILWGLVVYAAMIFVNRLIHGDQYGVMRGLFYVVIFAL
                     MMPRKPILLMLGYLAIVLGGMGLGMLSIWQYQHGMVRVEGFTNAILFSQAALTLAILNW
                     FVFQQRWLPRWFRRGALIGLIAALFALYLSQSRGVWLALGVILAYVICYKAYFKPWKYV
                     AVAILCTATTGAIYHTNQLVQVRVAEAVSDINSAEKGSYDSSWGLRVIAWQSAWLGFLD
                     SPVAGVGTDGFDALKQTQINNHQVSPLIFHPALVHSHNQYMQNLVVRGGIGFVALVIFL
                     GLPLYFAAKNINRISAGVLVPLAFAINSLSDVPFEHQGVLYLYTLSLVFIWFAHEFEKD
                     TCTS"
     gene            4576..5241
                     /gene="wahB"
     CDS             4576..5241
                     /codon_start=1
                     /gene="wahB"
                     /note="glycosyltransferase"
                     /product="WahB"
                     /protein_id="ACA14476.1"
                     /transl_table=11
                     /translation="MIPVFVISLARSVERRAMVVQQMAHLGINFEFVDATDGKALSSAE
                     LAKVDLELAKEVCGHELSFGEIGCAMSHIRVYERIVAEGIDRCVALEDDIYLHMHSKAI
                     IETIVRSCHSEIVFLHHGKAKRWPILSSLPGGYRLARYLAPSRTSRRGILSTAGYVLTL
                     AGAKKLLQCAYPLRMPSDYLTGRLQLNGLAASGVEPCCLDVDLFTTTIDDRAYGHYLE"
     gene            5327..6355
                     /gene="wahC"
     CDS             5327..6355
                     /codon_start=1
                     /gene="wahC"
                     /note="ADP-heptose-LPS heptosyltransferase"
                     /product="WahC"
                     /protein_id="ACA14477.1"
                     /transl_table=11
                     /translation="MNFKKLLTHCIAKWVIGSQPAAIPSPVGTEVANVLLVGYDAIGDF
                     ILSLPAIAQLRRLYPAARFDLVCSQRNALLAASVPGIDQCHVITLNDTLLPAGMWCKLR
                     ELRQRHYDVVINLFDEPDDIAMAKLLLLANGRLQSLPLRFKSEGQQKLLPLFNEKATIV
                     PSRPIRDHFVYRMLSVAGDQTDVPVTIPSPCNAQLDTSGYGRYLLVNLTGSQVGNSMAD
                     EQINGILAQLPVYPGVSYLVFSRRPLACQRQDMTALFPDTILDAAKIIKDAQGVISTDT
                     SIIHISSSFGVPTLVLMNNESWRDAFIPLSGRNIILRSTTDNLSALSPVEISRQVDALM
                     AL"
     gene            6410..7522
                     /gene="wahD"
     CDS             6410..7522
                     /codon_start=1
                     /gene="wahD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_9"
                     /gene_kind="biosynthetic-additional"
                     /note="ADP-heptose-LPS heptosyltransferase"
                     /product="WahD"
                     /protein_id="ACA14478.1"
                     /sec_met_domain="Glyco_transf_9 (E-value: 5.9e-11,
                     bitscore: 31.1, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLINDLQLKRDILRRKMGRFLFDRKRPEPTRESEGKVVLLRWDA
                     KLGDAIVSSWVARELKRVNPAREVWIVTTAAMAPLFRDHFGMDRVIEVPKRPGYCQLRR
                     LALSLGEVGCLVHFGKMLKMKDIFFISQVRADWVAGMDDALQAINLKLGAASRGMHFSD
                     KFALLLNRLGVADPDQRYIIPAPGQEASVASWWPDDVVLCFNPYGSGSSRRLKPELIRQ
                     MLERMLDACPFAICLLYPPGMEAEVAGIRAGLTRPERMVLSPDAPSLAGLFAQLRQSQG
                     LISVDTATIHIAAGLEQPILGLYNPDIGGGNENFLEWHPNSPLATVLFSENLREQDINS
                     LNLTEFDRLFRQWLLANQAALSVGQSPAQA"
     gene            complement(7458..8525)
                     /gene="wahE"
     CDS             complement(7458..8525)
                     /codon_start=1
                     /gene="wahE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_transf_9"
                     /gene_kind="biosynthetic-additional"
                     /note="ADP-heptose-LPS heptosyltransferase"
                     /product="WahE"
                     /protein_id="ACA14479.1"
                     /sec_met_domain="Glyco_transf_9 (E-value: 4.7e-26,
                     bitscore: 80.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYLVVQTKQIGDVLISTALCNNLKQNDPTGEVHYLVMDYCAGMA
                     QGNPNIDRLLIIEKARRNDWRYMKDLLLDIRREHYDVVVNSQGQMIGLLTCLFSGARLR
                     IGFDSFPWRLGHNRIVRFRKDTEFQGNSTLIDDRFSLLKPLKLAKEDRNYHLWLSEEEK
                     LQGRETLQAAGVDLARPLIAMGVNSLGHYKRWPIDCFAQVAQWLIEQHNAQILIYCGPG
                     EEEYNRGLKPLLPAALQGSVFDQIKTRSVRELVGLFAHCQLFVGNDTGPRHMAQAIDLP
                     LLTIVAPGGDKIIANPVNHPRYQAIDIFDAKGADFQLPQNAEKDFIDETLLRAITPELV
                     IARLTALPDWQVATA"
ORIGIN
        1 gccaaggtcg ggcaggtctt cgtcgttgac gtcaatgatc cccccttcac gcaggctcct
       61 gagcagggcg accacggagg aacgcaactg ctcctgggcc ttgaggtatt tttgctgcag
      121 cggctcatcg cgactcagga tgtccggtag atttgcgtag aagaagcgga actgccacat
      181 cagatagaag atggcatcca ggtagcccat caggttttcc agcttgatct cgttgctgcg
      241 cgccggggtg aagctctcgc tcaggtggcg ggcgtattga tcaaaaatcg agtggatgat
      301 gtcttcttta ttcctgaagt ggtaataaag gttgccaggg ctgatgccaa gatgcgcggc
      361 aatgtggttg gtggtgatgt tgcgctcacc ctgatcgttg aacagctcgg tggcgctatg
      421 aatgatcctg tctctggttt tcatcactgt tccctctgac gggcccgttg catcaaggtc
      481 gaatcccctt gcggcccgtg ataaactttt cggcaatttc aaattggctc actatacaca
      541 gctttaataa gcagtcacac gtgaccatca acgtacgcga ggcaaactcc atgatcgtag
      601 taactggcgg tgctggcttt atcggcagca atctggtcaa gcagctgaac gctcaaggac
      661 ggaccgacat cgtggtcatc gatgacctga ccgacggcac caagttcgtc aacctggtcg
      721 atctgaccat tgccgattac atggataagg acgagttcca ggcgcggatc gtctccggtg
      781 acgagtttga agagtgggac gacggcatcg aggtgatctt ccacgaaggt gcctgctccg
      841 cgaccactga gtggaacggc aagttcatca tggaggtcaa ttacgagtac tccaaggatc
      901 tgttccacta ctgcatcgag cgggaaatcc cgtttattta cgcctcctcc gccgcgacct
      961 acggtggccg caacgacaac ttcatcgaag atcccaagtt cgagcagccg ctcaacgtct
     1021 atggctactc caagcagctg ttcgaccagt acgtgcgccg ctggatgccg gagatcaact
     1081 cccaggtcgt gggtctgaag tatttcaacg tctacggtcc gcgcgagcaa cacaagggct
     1141 ccatggcttc cgttgccttc cacctcaata ctcaggtgaa gaagggcgag aatcccaagc
     1201 tgttcgaagg ctgtgacggt ttcccgaacg gtggccagat gcgtgacttc atctatgtgg
     1261 atgacgtctg caaggtgaat ctctggttct ggcagaaccc gcagcactcc ggcatcttca
     1321 actgcggtac cggtcgtgcc gagccgttcc agaacgtggc cgaagccgtg atccagcatc
     1381 atcagaaagg ggcaatcgag tacattccct tcccggatca cctcaagggt cgctatcaga
     1441 gcttcactca ggcagacatg accaggctgc gcggtgtcgg ttatgacgcc gagttcaaga
     1501 ctgtggccga aggcgtggcc gattacatgg cctggttgaa ccgggtttga tccccctctg
     1561 acgggtggcc cctggccacc cgtcgatcgg atacgcttcc atgaacatat tgatggcact
     1621 ctcccagctc gaagtgacgg gagctgaggt ctatgccacc acggtcggta acgaattgac
     1681 ccgacgtggt catcaggttt tctacgtatc ggacacgctg accaagccta cccagggccc
     1741 cgtgttcaag ctgcgtttca acaagcgcag catactgcgc cgcttctggc atgtgtttta
     1801 tctcatctac ctcatcaaga agcaccatat ccagttagtg catgcacact ctcgagcctc
     1861 cggctggagc agctatgttg cctgcaagct gaccggcact cccatggtta ccacggtaca
     1921 tggccgccag ccggtgcatg cctcccgcaa ggctttccat gccctcgggt tcagggccgt
     1981 ggccgtctgc gaggatattg cccaccagat catcgacaat ctgggggtgg atccggccat
     2041 agtgcaggtg ctgcgcaacg gcatcgagac tgacaagttt cagccagtgc cagcaccgga
     2101 caatgcaacg ccggtgatcg ccatcatagg gcggctgagc ggccccaagg gcgagctctg
     2161 ctatcgtctg ctggacgagg tgctggatct ggatgcctgt caggtaaggg tggtgagtgg
     2221 cagccagctg cctgagcgtt tccaccgctt tcagagtcag gtcgatttcg tcggttatgt
     2281 ggatgatgtc cctaccttgc tggcgggatg tgatctggtg atcggtgcag gccgggtggc
     2341 gatggaggcg ttgctgtgcg ggcgtcccgc ttttgccatc ggcgaggcca aggcgattgg
     2401 tctggtgacc gaacagaatc tagcggaggc gctggccagc aacttcggcg acataggccc
     2461 ccaggatctg gcgatcgact tcagtgcctt gaagacagag atagcacccg cattggccag
     2521 caagagtgtg cctgaggcca ttcgccagcg cattcaggat gagtatggct tggagaaagt
     2581 agtatccggg ctggaatcca tctatcagga tgcggtggtc gagaccctgc gccgcgagat
     2641 gcctgtcatc atgtaccacc gttttatcga gcatgacagc gagaaggggg tacatggtac
     2701 ctggatgcct attgccatgt tcgagaagca tcttcgttta atgaaatggc tgggttatga
     2761 aactctgact ttccgcgatc tggcggacag gggctttatc catcgtcttg aatacggcaa
     2821 gaagtacctg atgatcaccg ccgatgacgg ctatcaggac aacctgacgc gcatgctgcc
     2881 gttgcttgaa aaatacggtt acaaagccgt ggtatatgtg gtgaccggag aggcgcataa
     2941 tcgctgggat gtggagcatg ccaccaaccc ggatacccag gtttccctga tgaatgggga
     3001 gcagataaag gcccttgtgg cctctggcca tgtggaagtc ggtggccaca ccctgactca
     3061 tcccaggttg agcgagctct ctcctgagcg gcaagtccat gaaataagag aaaacaaacg
     3121 acaactcgag gccttgctag gtcactctct gctgtcgttc gcctaccctt atggggatat
     3181 ggacgagagc gccaaggtgc aggcacaggc agcaggctac cgttttgccg tggcgaccaa
     3241 cagtggtccc agagccatgc atcaggatcc ttaccggatc cgtcgcatcg ccattttccc
     3301 tcgtaccgat gtttttggcc tgtggcgcaa aatccggggt aactatgtct tcaggaaata
     3361 atgattaatg cccatcagat gcctttatct gctcgataaa accaccacag ccctgtttgc
     3421 attgaccatc attttttcct tttgcggcct ttttttggta cctgccggcc agagcattga
     3481 atctaatctg ctggccgtga ccggcatatt tggcttgctg aactactttg tcggcaagca
     3541 acaagatgtt ggactgaaag atcgccgcat tctctgggga ctggtagtgt atgccgccat
     3601 gattttcgtc aaccggttga ttcatggtga tcaatatggg gtcatgcgcg ggctgtttta
     3661 tgttgttatc tttgcactga tgatgccgcg caagccaatt ctattgatgc tgggttatct
     3721 ggctatcgtc ctgggcggga tgggactggg aatgctcagc atctggcagt atcagcatgg
     3781 tatggtcagg gttgaagggt ttaccaacgc cattctcttt tcacaagcag cattgacgct
     3841 ggcgatcctc aactggtttg tctttcagca gagatggctg cctagatggt ttcggagggg
     3901 ggctcttatt ggcctgattg cggccctgtt tgcgctttat ctctcccaga gccggggggt
     3961 ctggcttgcc ctcggggtca ttcttgccta cgtcatctgt tacaaggcct atttcaagcc
     4021 gtggaaatac gttgcggtag ccatattgtg tacggccacg acgggcgcca tttatcatac
     4081 caatcagctg gttcaggttc gggtcgcgga ggcggtctcg gatatcaact cggcagaaaa
     4141 gggctcgtac gattcatcgt ggggtctgcg tgtcattgcc tggcagagtg cctggctggg
     4201 ttttttggat tcgcctgtgg caggagtggg cactgatggc ttcgacgcat tgaaacaaac
     4261 ccagatcaat aatcatcagg tctctcccct gatatttcat ccggcgctgg tccactcgca
     4321 taatcaatat atgcagaacc tggtggttcg aggcggcatc ggatttgttg cattggtgat
     4381 atttcttggc ctgccgctct attttgccgc gaaaaatata aacaggattt ctgcaggggt
     4441 actggtgcct ctggcgtttg cgattaattc gctaagcgat gttccgtttg aacatcaagg
     4501 ggtgctctat ttgtatacgc tcagcctggt tttcatctgg tttgcccatg agtttgaaaa
     4561 ggatacctgt acgtcatgat tccggttttt gtcatcagtt tggctcgcag cgttgagcgg
     4621 cgggcgatgg ttgtacagca gatggcgcat ctgggcatca atttcgagtt cgtagatgcg
     4681 accgatggga aagcattgag cagcgcggaa cttgccaagg ttgacttgga gctggccaaa
     4741 gaagtgtgtg gccatgagct gagttttggt gagattggct gtgccatgag ccatatccgt
     4801 gtttatgagc gcatagtcgc cgagggaatt gatcgctgcg tggcgttgga agatgacatt
     4861 tacctgcaca tgcacagcaa ggcgatcatc gagacgatag tgcgctcctg ccattcggag
     4921 atcgtcttcc tgcatcatgg caaagccaag cgctggccaa ttctttcctc cttgccgggt
     4981 ggttatcggc ttgccagata tctggcaccg agtcgcacct ccaggagagg gatcctgtcg
     5041 accgcagggt atgttctgac cctggccggg gcgaagaaat tattgcagtg tgcttatccg
     5101 ctgcgcatgc cttccgatta tctgactggt cgcctgcagc ttaatggcct ggctgcctcc
     5161 ggtgttgagc cctgctgcct ggatgtggat ctctttacca ccacgattga tgatcgggct
     5221 tacggccact atctggaata ggcgggttgt cttggccggg attggggtca gtaaacaccc
     5281 atgctgtcct ggctggcgaa gtggggccat atatgctgga taatctatga atttcaaaaa
     5341 gttgcttacc cattgcatcg ccaagtgggt cattggcagc cagcctgctg ccattccaag
     5401 ccccgtcgga acagaagtgg caaacgtgct gctggtcggt tatgacgcca tcggcgattt
     5461 cattctgtca ttgcccgcca ttgcgcagct caggcgcctg tatccagccg cccgatttga
     5521 cctcgtgtgc agccagcgca acgcgctgct ggcggcatct gtgccaggta ttgatcaatg
     5581 ccatgtgatc accctgaacg acaccctgtt gccagcgggc atgtggtgca aactccgcga
     5641 gctcaggcaa cggcactatg acgtggtcat caacctgttc gatgagcccg acgatatcgc
     5701 catggccaag ctgctgttgc tggccaatgg tcgattgcag tcgttgcccc tgcgcttcaa
     5761 gagcgaaggg cagcagaagt tgctgccgct gttcaacgaa aaggccacca tagtgccatc
     5821 acgccccatc cgggatcatt tcgtctatcg catgctcagc gtggcggggg atcaaacgga
     5881 tgtaccggtt accataccat cgccctgcaa tgcacagctg gataccagtg gttatgggcg
     5941 ctatctgctg gtcaatctga cgggcagcca ggtgggcaat tcgatggcgg atgagcaaat
     6001 caacggcatt ctggcccaat tgccggtgta tcctggggtt tcctatctgg tcttctccag
     6061 gcgtcctttg gcatgccagc ggcaggatat gacagccctg tttcccgaca ccattctcga
     6121 tgcggcaaag attatcaagg atgcgcaggg ggtcatctcg accgacacct ccatcatcca
     6181 tatctcgtct tcgttcggcg tgccgactct ggtgctgatg aacaacgagt cctggcgcga
     6241 tgcctttatt ccgctctctg gccgcaatat catcctgaga tcgaccacgg acaacctttc
     6301 cgctctttcg cctgtcgaga tcagccgtca ggtcgatgcc ttgatggcgc tgtagttgcg
     6361 tcagactgtt atcatatctt cccaattcaa cggccatcct ggtggattta tgtcattaat
     6421 caacgacctg caactcaagc gtgacattct tcgccgcaag atgggacggt tcctgtttga
     6481 tcgaaaacgg cctgaaccca ccagggagag cgaggggaaa gtcgtcctgc tgcgctggga
     6541 tgccaaactg ggcgatgcga tcgtctcgtc ctgggtggcc cgcgaactaa agcgggtcaa
     6601 cccggcacgt gaggtgtgga tcgttacaac ggcagccatg gctcccctgt ttcgcgatca
     6661 tttcggcatg gatagggtca tcgaggtgcc caagcgcccc ggttattgtc aactcaggcg
     6721 gcttgcactg tcattggggg aggtcggttg cctggttcac tttggcaaga tgttgaagat
     6781 gaaggatatc tttttcatca gccaggtcag ggcagattgg gtcgccggca tggacgacgc
     6841 cttgcaggcc atcaatctca agctgggagc cgcgtccaga ggtatgcact tctccgacaa
     6901 gtttgccctg ctgttgaatc gactcggagt ggcagacccg gatcagcgct acatcatccc
     6961 cgctccgggt caggaggcgt cggttgcgag ctggtggccc gatgatgtcg tgctctgctt
     7021 caacccttat ggcagcggta gttcccgccg tctgaagccg gagctgatcc ggcagatgct
     7081 ggagaggatg ctggacgcct gcccatttgc catctgcctg ctttatccac cgggtatgga
     7141 ggctgaagta gcggggatcc gggccgggct cacccgaccc gagcgcatgg tattgtcacc
     7201 cgatgcgccc tcgctggcgg gccttttcgc ccagttgcgt cagagccagg gcctcatttc
     7261 ggtggatacg gcgaccatac atatcgcggc cgggctggag caacccattc tgggtctcta
     7321 caacccggat atagggggtg gcaacgagaa tttcctggaa tggcatccca actccccgtt
     7381 ggcgaccgtg ctgttctcgg agaatctccg cgaacaggac atcaactctc tcaacctgac
     7441 cgagttcgac cggctattca ggcagtggct acttgccaat caggcagcgc tgtcagtcgg
     7501 gcaatcacca gctcaggcgt aatggcgcgc aacagggttt catcgatgaa gtctttctcc
     7561 gcattttgcg gcagctggaa gtcggcgccc ttggcatcga agatatcgat ggcctgatag
     7621 cgggggtggt tgaccggatt ggcgatgatc ttgtcgccgc cgggagccac tatggtcagc
     7681 aggggcaggt cgatggcctg ggccatgtgg cgggggccgg tatcgttgcc gacaaacagt
     7741 tggcaatggg cgaacagccc taccagctcc cgtaccgagc gggtcttgat ctgatcaaac
     7801 acgcttccct gcaaggcggc aggcagcagc ggcttgagac cgcggttgta ctcctcttct
     7861 cccggcccgc agtagatcag gatctgggcg ttgtgctgtt cgatgagcca ctgggcaacc
     7921 tgggcgaagc agtcgatggg ccagcgcttg tagtgcccca gcgagttgac gcccatggcg
     7981 atcaagggcc gtgcgagatc gacgccagcc gcctgcaagg tttcccgtcc ctgcagcttc
     8041 tcctcttcgc tcagccagag atggtaattg cgatcttctt tggccagttt gagcggtttg
     8101 agcagcgaga agcggtcgtc gatcagggta ctgttgccct ggaattcggt gtctttgcga
     8161 aagcgcacta tgcggttgtg gccgagccgc caggggaagg agtcaaatcc tatccgcaac
     8221 ctggcgccgg agaagaggca ggtcagcagg cctatcatct ggccctggct gttgactacc
     8281 acgtcatagt gttcgcggcg gatgtccagc agcaggtctt tcatgtagcg ccagtcgttg
     8341 cgcctggctt tctcgatgat gaggagtcga tcgatattgg gattgccctg cgccataccc
     8401 gcgcaataat ccatgaccag atagtgaact tccccggttg gatcgttctg cttgaggttg
     8461 ttgcacagcg cggtggagat cagtacatcc cctatctgtt tggtttgtac tacaaggtat
     8521 ttcataaggc aggcctcaat agaggtcgtt gttgagcatc agcgtgacag cataccgcac
     8581 aagcgagtca gatgctgtcg gtcaggaatg aaaatccgat ctggctcaag ccaatggcgg
     8641 tgtggtgcag gcatggagta gaagcccgtc gttgacgggc ttctcgcatt cattactcga
     8701 tgttctggat ctgctcacgc atctgctcga tgagcacctt caactcgacg gcggactggg
     8761 tcacctcggc gttgatggac ttggagccca gcgtgttcga ctcgcggttg aactcctgca
     8821 tcatgaagtc cagacggcga ccacaggcgc cacccttctt catgatcttg atggtttcgc
     8881 tgatgtgcat ctccagtcga tccagctctt cggccacgtc gatcttctgg gccagcagca
     8941 cgatttcctg ctcgatccgg gccggatcca gctccacctt ggcctcggtc aggcgatcgg
     9001 tgagcttctg gcgctgccac tcgatgatct gcggcaggtg tatgcgcacc ttcttcactt
     9061 ccacctgaat gccatccaga cgctgctgga tcaagttctt gaggttggcc ccttcactgg
     9121 cgcgggaggc gatgaagtct tccatggtct ggtcaaaccc gccgagcagc tcggtggcaa
     9181 ccgcgtccat gtcctgctcg gcggcggcca tgacacccgg ccagcgcagc acgtcgactg
     9241 ggttgagctg gccctggcct gcctctttca ttacccagtt ggcgctgtcg atgatcagct
     9301 tggccagctc ttcattgatg tgcagctggc tggcggccgc ctgagcggct tcgaaacgca
     9361 ggttgcactc caccttgccg cgttgcagct tggcacggaa acgctcacgc agcaccggct
     9421 ccaggctgcg cagttgctcc ggcagacgga tataggtttc cagatagcgc tggttgaccg
     9481 aacgaatttc ccaaacggct gtgccccagt cgcccttgaa ttccttgcgg gcgtaggcgg
     9541 tcatgctgtg aatcattgat tgttccgggc ttgatgaagt gtgcggccag tatactcagc
     9601 cagacttgtc ccgtcagcca tagccgtggc tttagaacct gttccggctt ttgtgggaca
     9661 gtgttgagcc gggcccggtg ctgccctggc tcatgaacga gggtgatagg cgccggtttc
     9721 tgcgtggttc ctcacctttg agatgactgc tcttgaccga tcatgaacgg cttcttagcg
     9781 gctgatattt ggggctggat cacttatact ccttcgccaa tttgagccag cccagaggtc
     9841 cgttccatgt cacgtccaag cgatcgcagt gccgcgcaac ttcgcccggt taccattacc
     9901 cgcaatttca ccaaacatgc agaaggctca gtgctggtgg agttcggtaa cactcgcgtg
     9961 ctctgcaccg ccagcgtcga caccagcgta ccgcgcttcc tgaaagggaa gggtcagggt
    10021 tgggtcactg ccgaatacgg catgctgccg cgctccactc actctcggat gaaccgcgaa
    10081 gcggccgccg gcaagcagag tggccgtact ctggagatct cccgtctgat cgcccgctcc
    10141 ctgcgtgcgg cggtagatct gactgcgctg ggcgagcact ccatcacagt tgactgcgac
    10201 gtgctgcaag ccgatggcgg tacccgcacc gcctccatta ccggtgcctg cgtggcgctg
    10261 gtggatgcgc tgaactggat ggtcgagaaa ggcatgctca agcagagccc gctcaagcag
    10321 atgatcgccg ccgtctccgt cggcatgtat cagggcgaag ccatctgcga tctggagtac
    10381 atcgaagact ccgccgccga gaccgacatg aacgtggtga tgaccgaaga tggtcgcatc
    10441 atagaggtgc agggcaccgc ggaggccgag cccttcaccc atgaggagct gctggcgatg
    10501 ctggggctcg ccaagggcgg cattgaagag atcattgcgc tgcag
//
