LOCUS       BGC0000794             19983 bp    DNA     linear   BCT 22-JUL-2008
DEFINITION  Geobacillus stearothermophilus strain NRS 2004/3a surface layer
            glycoprotein SgsE precursor (sgsE) gene, complete cds; and S-layer
            glycan biosynthesis (slg) gene cluster, partial sequence.
ACCESSION   BGC0000794
VERSION     BGC0000794
KEYWORDS    .
SOURCE      Geobacillus stearothermophilus
  ORGANISM  Geobacillus stearothermophilus
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Geobacillus.
COMMENT     On Jan 23, 2004 this sequence version replaced AF328862.1.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:13:15
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..19983
                     /db_xref="taxon:1422"
                     /mol_type="genomic DNA"
                     /organism="Geobacillus stearothermophilus"
                     /strain="NRS 2004/3a"
     subregion       1..19983
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000794"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..19983
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     regulatory      475..481
                     /gene="sgsE"
                     /regulatory_class="ribosome_binding_site"
     gene            475..3270
                     /gene="sgsE"
     sig_peptide     493..582
                     /gene="sgsE"
     CDS             493..3204
                     /codon_start=1
                     /gene="sgsE"
                     /note="S-layer glycoprotein"
                     /product="surface layer glycoprotein SgsE precursor"
                     /protein_id="AAL46630.1"
                     /transl_table=11
                     /translation="MDKKKAVKLATASAVAASAFVAANPHTSQAATDVATVVSQAKAQM
                     KEAYYTYSHTVTETGQFPDIKDVYAAYNKAKQAYANAVAVVNKAGGAKKDAYLADLQAT
                     YETYVFKANPKSGEARVATYIDAYNYATKLDKMRQELKAAVDAKDLKKAEELYHKISYE
                     LKTRTVILDRVYGQSTRELLRSTFKADAQALRDSLIYDITVAMKAREAQDAVKAGNLDK
                     AKAALDQVNQYVSKVTDAFKAELQKAAQDAKAAYEAALPPKVESVTAVNAKTLEIKFNK
                     AVDAATVIDNKGTSDTSDDVVKATAITLKAIDDQVPVSTVKASLSDDKKTLKLVVDGAQ
                     FFTKRYVVDIKNVKTLDGKDVPAYTTTIDTTDSVRPSVLSFSYADNGLTLKVKFSEPLA
                     SVGTVKLYDGTTEISVSPKFTAGDDEMTINLASSSVPVNKDLTLKIFGAVDYNGNVINP
                     NPAELTVKKTTVDITKPVVQSIEAVNTKTVKVTFSEKLLSAPTIKIGGQTASVSVDSTG
                     LVYTATLASALSKGVYAVEVSDYKDLAGNSGDAYTKVVQLKADNTAPKFVSSQVVKING
                     VEHLVLTFDEEVTTGSNITVVQSSDKYIDENNVLKAVGADLKTTSDNFKLYLPTDGKSK
                     SVALNISSLPKGTYTVTLPNGLVSDLADNPYAERKQITFVRGSDSLTTKPALDKDYDSN
                     GVKADNNNELVFAFTQNLDASALNLSNFNINGLTVTKAVFDGDTKHIRVTLAPGANTWT
                     GTHVITISNIKNTSGLVMDTVTVNEYMKENVAPTFTATLTSADVIRVDFSEPVANATIS
                     RALSANNFIVKVDGNVVTVSNVYEDNNATNLVQGSKGYKTVYLKLQSPVTDLSKPITLS
                     ATDIVDVNQTGAITDNNVVGNNVSATVVNVAK"
     misc_feature    2350..2352
                     /gene="sgsE"
                     /note="glycosylation site"
     misc_feature    2872..2874
                     /gene="sgsE"
                     /note="glycosylation site"
     regulatory      3230..3270
                     /gene="sgsE"
                     /regulatory_class="terminator"
     regulatory      3410..3415
                     /gene="wsaA"
                     /regulatory_class="ribosome_binding_site"
     gene            3410..3935
                     /gene="wsaA"
     misc_feature    3410..>19983
                     /note="S-layer glycan biosynthesis (slg) gene cluster"
     CDS             3426..3935
                     /codon_start=1
                     /gene="wsaA"
                     /note="putative TPR-repeat containing protein"
                     /product="WsaA"
                     /protein_id="AAR99603.1"
                     /transl_table=11
                     /translation="MQNEENLLMHGKWDRYVFLSLLVLILSGISYAHWKGQQQDEQFLK
                     DYTEYQQAIQLMQQGRAEQALPLLRSLLGKYPDRYNIMRTLGLAYAMKNDFQKAAFYYE
                     KAIRKRPFLQQDPIFTLQFGEILYYNGEYAKAKAYLEQSKQLPGSETYHARIDELLSQI
                     QHQKSS"
     regulatory      3939..3944
                     /gene="wsaB"
                     /regulatory_class="ribosome_binding_site"
     gene            3939..5530
                     /gene="wsaB"
     CDS             3950..5530
                     /codon_start=1
                     /gene="wsaB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /note="putative ligase; similar to WaaL"
                     /product="WsaB"
                     /protein_id="AAR99604.1"
                     /sec_met_domain="Wzy_C (E-value: 2.5e-25, bitscore: 79.4,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDWYKYLNIERDEHEDQLDMERVDAILFWGLAFIVLAIPLIVRV
                     HIGDFISPSITEADILDTGKKADVFTYYKHILLLISTACLSLLFIYKVAVLRYSIPKTK
                     INISLALLAIFITLSAVFAPYKTLALYGMYDRNEGTITYLCYLMLFFIAANIHYTEKRL
                     KWALYCLYPFVMINTLLGIVNFYGYNVLELNWVKKLLYSNLPQGAKLTEGSRLIATINH
                     GNYVSGISAVLTTLFFTWALLDKNKIRSIVNFVMSLLCFAMLLSSLSVSGFLTLTLILP
                     IVFLFVFKSIYKRKFAVTFATFLVGAACVYVVMVNHNPKVWDETFGFFIKSNPFAEARA
                     VVDELQQAFDASHVYAETGSNQENKEYQLPQLPESGVGPGSGRLYIWKKTWELIQYRPL
                     FGYGLDTLPYFFPQDDPEKQANIETYTVIVDKPHNMYIGIAYGAGVIALLAFVAFIVNI
                     GLLTIKRFISTKLVDDKQAIFASVAIACGAYLIQALFNDSIIGTAVIFWILLGLLVSFL
                     IQNKQEKVS"
     regulatory      5514..5519
                     /gene="wsaC"
                     /regulatory_class="ribosome_binding_site"
     gene            5514..6511
                     /gene="wsaC"
     CDS             5537..6511
                     /codon_start=1
                     /gene="wsaC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="putative rhamnosyltransferase"
                     /product="WsaC"
                     /protein_id="AAR99605.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.4e-27,
                     bitscore: 86.7, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMPLVSIVVATYFPRTDFFEKQLQSLNNQTYENIEIIICDDSAN
                     DAEYEKVKKMVENIISRFPCKVIRNEKNVGSNKTFERLTQEANGDYICYCDQDDIWLSE
                     KVERLVNHITKHHCTLVYSDLSLIDENDRIIHKSFKRSNFRLKHVHGDNTFAHLINRNS
                     VTGCAMMIRADVAKSAIPFPDYDEFVHDHWLAIHAAVKGSLGYIKEPLVWYRIHLGNQI
                     GNQRLVNITNINDYIRHRIEKQGNKYRLTLERLSLTLQQKQLVYFQIHLTEARKKFSQK
                     PCLGNFFKIVPLIKYDIILFLFELMIFTVPFTCSIWIFKKLKY"
     regulatory      6522..6527
                     /gene="wzm"
                     /regulatory_class="ribosome_binding_site"
     gene            6522..7340
                     /gene="wzm"
     CDS             6534..7340
                     /codon_start=1
                     /gene="wzm"
                     /product="Wzm"
                     /protein_id="AAR99606.1"
                     /transl_table=11
                     /translation="MRLLGDIRSLFLHRSLIMQFIKREVRSRYQGSYLGIVWSFITPLM
                     MLMIYTFVFSVVFKARWGTSSGDSKVEFALLLFSGLIVFNIFSEVVSRAPMLITSNVNY
                     VKKVVFPLEVLPIVILGSSLFHLGINIVILIIAILIFTGKIYWTVILLPLVLLPICLFT
                     LGLGWFLASLGVYIRDIGQVMSVVTSALMFLSPIFYPISAIPKELQFLYYINPISYVVE
                     DVRRITVWGLLPHWNWLIIGTVFGVIIALLGLIWFKKTRGGFADVL"
     regulatory      7316..7321
                     /gene="wzt"
                     /regulatory_class="ribosome_binding_site"
     gene            7316..8559
                     /gene="wzt"
     CDS             7330..8559
                     /codon_start=1
                     /gene="wzt"
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 154.4; E-value:
                     6.7e-47)"
                     /gene_kind="transport"
                     /product="Wzt"
                     /protein_id="AAR99607.1"
                     /transl_table=11
                     /translation="MSSDIAIKVENLSKIYQIYDRPIDRLKQSLLRGRRKYYREFTALN
                     NVSFQIRKGETVGIIGKNGSGKSTLLQILAGTLTPTSGSVEVNGRVAALLELGSGFNPE
                     FTGRENVYMNGAILGISKEEMDRRFNEIAEFADIGDFIDQPVKTYSSGMYVRLAFSIAI
                     NVDADILIVDEALAVGDIKFQIKCIDKMKEIKNKGTTILFVSHSGEQVKRFCDRAIWLQ
                     QGSIRYIGSSSEVVNRYEDSLQLEMLKDHQREVAVSNERINKDLINEQETESNVDIIAK
                     INSVTVDKNRIETFEELIVYVKYTIFENEVPNFLLGVAIYGNDRKYIFGPNTYLDKVEI
                     PKTKGTHTIMYKIPKIPLLAGTYFIDTGIFTDGGLVCIDYKSDVCQFNVESNYFTEGLV
                     HMEHEWSVVE"
     regulatory      8530..8535
                     /gene="wsaE"
                     /regulatory_class="ribosome_binding_site"
     gene            8530..11924
                     /gene="wsaE"
     CDS             8541..11924
                     /codon_start=1
                     /gene="wsaE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="putative methyltransferase"
                     /product="WsaE"
                     /protein_id="AAR99608.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2.1e-34,
                     bitscore: 108.8, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERCRMNKKIPFDQYQRYKNAAEIINLIREENQSFTILEVGANEH
                     RNLEHFLPKDQVTYLDIEVPEHLKHMTNYIEADATNMPLDDNAFDFVIALDVFEHIPPD
                     KRNQFLFEINRVAKEGFLIAAPFNTEGVEETEIRVNEYYKALYGEGFRWLEEHRQYTLP
                     NLEETEDILRKENIEYVKFEHGSLLFWEKLMRLHFLVADRNVLHDYRFMIDDFYNKNIY
                     EVDYIGPCYRNFIVVCRDKAKREFIQSIYEKRKQNSYLKNSTISKLNELENSIYSLKII
                     DKENQIYKKSLEITEQLLEDLKLKEQQIIEKIQTIKKKTEMIELQNQKIQELKIECENK
                     SIENNNLYSQLLEKENYIKQLQNQAESMRIKNRLKKILNFSFIKYVRKIINIIFRRKFK
                     FKLQPVHHLEWSNGKWLVLGRDPHFILKGGSYPSSWTIIQWRASANSSALLRLYYDTGG
                     GFSENQSFNLGKIGNDINRDYECVICLPENIHLLRLDIEGEISEFELENLTFTSISRLE
                     VFYKSFINHCRKRNIKNYKELYSLIKKLFILVRREGLKSIWYRAKQKLSMELLSEDPYE
                     VFLNVSSKVDKEIVLSEIKKLKYKPKFSVILPVYNVEEKWLRKCIDSVLNQWYPYWELC
                     IVDDNSSKDYIKPVLEEYSNRDSRIKTVFRSNNGHISEASNTALEIATGDFIALLDHDD
                     ELAPEALYENAVLLNEHPDADMIYSDEDKITKDGKRHSPLFKPDWSPDTLRSQMYIGHL
                     TVYRTNLVRQLGGFRKGFEGSQDYDLALRVAEKTNNIYHIPKILYSWREIETSTAVNPS
                     SKPYAHEAGLKALNEHLERVFGKGKAWAEETEYLFVYDVRYAIPEDYPLVSIIIPTKDN
                     IELLSSCIQSILDKTTYPNYEILIMNNNSVMEETYSWFDKQKENSKIRIIDAMYEFNWS
                     KLNNHGIREANGEVFVFLNNDTIVISEDWLQRLVEKALREDVGTVGGLLLYEDNTIQHA
                     GVVIGMGGWADHVYKGMHPVHNTSPFISPVINRNVSASTGACLAIAKKVIEKIGGFNEE
                     FIICGSDVEISLRALKMGYVNIYDPYVRLYHLESKTRDSFIPERDFELSAKYYSPYREI
                     GDPYYNQNLSYNHLIPTIRS"
     gene            11929..13170
                     /gene="wsaF"
     CDS             11929..13170
                     /codon_start=1
                     /gene="wsaF"
                     /note="putative rhamnosyltransferase; similar to RfbC"
                     /product="WsaF"
                     /protein_id="AAR99609.1"
                     /transl_table=11
                     /translation="MLQKLIQILRRNEYVKNVYKNTVSNFIETSIPEITPFNARTSSIK
                     GKRLNLLVPSINQEHMFGGISTALKLFEQFDNKKFKKRIILTDATPNPKDLQSFKSFKY
                     VMPEEDKDFALQIVPFNDRYNRTIPVAKHDIFIATAWWTAYAAQRIVSWQSDTYGIPPN
                     KILYIIQDFEPGFYQWSSQYVLAESTYKYRGPQIAVFNSELLKQYFNNKGYNFTDEYFF
                     QPKINTTLKNYINDKRQKEKIILVYGRPSVKRNAFTLIVEALKIFVQKYDRSNEWKIIS
                     VGEKHKDIALGKGIHLNSLGKLTLEDYADLLKRSSIGISLMISPHPSYPPLEMAHFGLR
                     VITNKYENKDLSNWHSNIVSLEQLNPENIAETLVELCMSFNNRDVDKKESSNMMFYINE
                     FNEFSFIKEIEEKL"
     regulatory      13410..13415
                     /gene="rmlA"
                     /regulatory_class="ribosome_binding_site"
     gene            13410..14326
                     /gene="rmlA"
     CDS             13427..14326
                     /EC_number="2.7.7.24"
                     /codon_start=1
                     /function="transfers dTMP residue to glucose 1-phosphate"
                     /gene="rmlA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 294.4; E-value:
                     1.4e-89)"
                     /gene_kind="biosynthetic-additional"
                     /note="RmlA"
                     /product="glucose-1-phosphate thymidyltransferase"
                     /protein_id="AAR99610.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 7.6e-13, bitscore:
                     39.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLYPLTKAISKQLLPIYDKPMIYYPLSVLMLAG
                     IRDILIISTPEDTPRFEQLLGDGSDLGISLSYAVQPSPDGLAQAFIIGEEFIGNDHVAL
                     ILGDNIFYGHGFTAMLERAASRKSGATIFGYNVKDPERFGVVEFDKNGKVISIEEKPEN
                     PRSTYAVTGLYFYDNRVIDIAKSLQPSARGELEITDVNKAYLELGELHVELLGRGFAWL
                     DTGTHESLLEASLFIETIEKRQSLKVACLEEIAYRKGYISREQLLKLAELLKKNGYGQY
                     LLDIANRVSKEGELIENY"
     regulatory      14298..14303
                     /gene="rmlC"
                     /regulatory_class="ribosome_binding_site"
     gene            14298..14864
                     /gene="rmlC"
     CDS             14313..14864
                     /EC_number="5.1.3.13"
                     /codon_start=1
                     /function="converts dTDP-6-deoxy-D-xylo-4-hexulose into
                     dTDP-6-deoxy-L-lyxo-4-hexulose"
                     /gene="rmlC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) dTDP_sugar_isom"
                     /gene_kind="biosynthetic-additional"
                     /note="RmlC"
                     /product="dTDP-4-dehydrorhamnose 3,5-epimerase"
                     /protein_id="AAR99611.1"
                     /sec_met_domain="dTDP_sugar_isom (E-value: 7.4e-75,
                     bitscore: 240.3, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIIETKFSNAFLLEPKVFGDHRGFFMESYNDKVFKELGFNYEFV
                     QDNHSLSVEVGTLRGLHYQLEPYAQTKLVRVVRGAIYDVIVDIRKGSPTYGEWQGFILT
                     EWNKRQLLVPKGFAHGFCTIVPNTEVIYKVDNYYSPEHDRGICWNDPDLKIDWPTHSPI
                     LSEKDSKHPRLAEAENNFTY"
     regulatory      14864..14869
                     /gene="rmlB"
                     /regulatory_class="ribosome_binding_site"
     gene            14864..15902
                     /gene="rmlB"
     CDS             14874..15902
                     /EC_number="4.2.1.46"
                     /NRPS_PKS="Domain: NAD_binding_4 (6-181). E-value: 9.1e-19.
                     Score: 59.4. Matches aSDomain:
                     nrpspksdomains_rmlB_NAD_binding_4.1"
                     /codon_start=1
                     /function="converts dTDP-D-glucose to
                     dTDP-6-deoxy-D-xylo-4-hexulose"
                     /gene="rmlB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     304.7; E-value: 1.3e-92)"
                     /gene_kind="biosynthetic-additional"
                     /note="RmlB"
                     /product="dTDP-glucose 4,6-dehydratase"
                     /protein_id="AAR99612.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.8e-24, bitscore:
                     75.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 3e-20, bitscore:
                     62.4, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.4e-19, bitscore:
                     59.4, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQMKVLITGGAGFIGSNFVNYMVQKYPSYQIINLDALTYAGNLEN
                     VKEVENEPNYRFVKGDITDRELIESLFAEGIDAVVNFAAESHVDRSIADPGIFIKTNVQ
                     GTQVLLDAAKKYGVKKYIQISTDEVYGTLGETGYFTETTPLAPNSPYSASKAGADLLVR
                     AYHETYGLPVNITRCSNNYGPYHFPEKLIPLMIINALNNQPLPVYGDGLNVRDWLHVED
                     HCSAIDLVLHHGKNGEVYNVGGNNERTNIEVVKAILRYLNKPESLITFVEDRLGHDRRY
                     AIDATKIREELGWQPKYTFEEGLKQTINWYLENRSWWENILSGEYKEYYKRQYGQKLGR
                     SS"
     aSDomain        14892..15416
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rmlB_NAD_binding_4.1"
                     /evalue="9.10E-19"
                     /label="rmlB_NAD_binding_4.1"
                     /locus_tag="rmlB"
                     /protein_end="181"
                     /protein_start="6"
                     /score="59.4"
                     /tool="antismash"
                     /translation="ITGGAGFIGSNFVNYMVQKYPSYQIINLDALTYAGNLENVKEVEN
                     EPNYRFVKGDITDRELIESLFAEGIDAVVNFAAESHVDRSIADPGIFIKTNVQGTQVLL
                     DAAKKYGVKKYIQISTDEVYGTLGETGYFTETTPLAPNSPYSASKAGADLLVRAYHETY
                     GLPVNITRCSNN"
     regulatory      15885..15892
                     /gene="rmlD"
                     /regulatory_class="ribosome_binding_site"
     gene            15885..16747
                     /gene="rmlD"
     CDS             15899..16747
                     /EC_number="1.1.1.133"
                     /NRPS_PKS="Domain: NAD_binding_4 (43-161). E-value: 2e-08.
                     Score: 25.5. Matches aSDomain:
                     nrpspksdomains_rmlD_NAD_binding_4.1"
                     /codon_start=1
                     /function="reduces dTDP-6-deoxy-L-lyxo-4-hexulose to
                     dTDP-L-rhamnose"
                     /gene="rmlD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 84.4;
                     E-value: 1.6e-25)"
                     /gene_kind="biosynthetic-additional"
                     /note="RmlD"
                     /product="dTDP-4-dehydrorhamnose reductase"
                     /protein_id="AAR99613.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.8e-114,
                     bitscore: 371.6, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.7e-10,
                     bitscore: 29.8, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIVVTGANGQLGQELVGQLQQTNVELYSFTKSDLDITNDSIVNE
                     TITKIKPDILINAAAYTKVDQAEIEEETAYLVNAFGQRNLAIAAEKVGAKICYISTDYV
                     FDGTSMTPYREYDRTNPLGVYGKSKYAGEELTKSLCSRYFIVRTAWVYGEFGQNFVKTM
                     LRLAKEKEEIGVVNDQIGSPTYTVDLARFIIELVQTEKFGIYHATNSGSCSWYEFAKAI
                     FEESNIHVKVNPITTEQFPRPAARPKYSVLDNFAMKVNGFPMLRHWREALKEFLKSDFR
                     I"
     aSDomain        16028..16381
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rmlD_NAD_binding_4.1"
                     /evalue="2.00E-08"
                     /label="rmlD_NAD_binding_4.1"
                     /locus_tag="rmlD"
                     /protein_end="161"
                     /protein_start="43"
                     /score="25.5"
                     /tool="antismash"
                     /translation="NETITKIKPDILINAAAYTKVDQAEIEEETAYLVNAFGQRNLAIA
                     AEKVGAKICYISTDYVFDGTSMTPYREYDRTNPLGVYGKSKYAGEELTKSLCSRYFIVR
                     TAWVYGEFGQNFVK"
     regulatory      16820..16825
                     /gene="wsaD"
                     /regulatory_class="ribosome_binding_site"
     gene            16820..17699
                     /gene="wsaD"
     CDS             16830..17699
                     /codon_start=1
                     /gene="wsaD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /note="putative rhamnosyltransferase"
                     /product="WsaD"
                     /protein_id="AAR99614.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 2e-37, bitscore:
                     118.6, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDISIIIVNYNTPKLTVEAIESILKSKTKYSYEIIVVDNHSSDDS
                     VRILKGKFPNIVVIENKQNVGFSKANNQAIKLSKGRYILLLNSDTIVKEDTIEKMIEFM
                     DKSKKVGASGCEVVLPNGELDRACHRGFPTPEASFYYLVGLARLFPRSRRFNQYHLGYM
                     NLNEPHPIDCLVGAFMMVRREVIEQVGLLDEEFFMYGEDIDWCYRIKQAGWEIYYCPFT
                     SIIHYKGASSKKKPFKIVYEFHRAMFLFHRKHYARKYPFIVNCLVYTGIAAKFILSAII
                     NTFRKIGG"
     regulatory      17683..17688
                     /gene="wsaP"
                     /regulatory_class="ribosome_binding_site"
     gene            17683..19107
                     /gene="wsaP"
     CDS             17692..19107
                     /codon_start=1
                     /gene="wsaP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146:sugar transferase (Score: 364; E-value:
                     1.9e-110)"
                     /gene_kind="biosynthetic-additional"
                     /note="WsaP"
                     /product="putative UDP-galactose-lipid carrier transferase"
                     /protein_id="AAR99615.1"
                     /sec_met_domain="Bac_transf (E-value: 4.4e-77, bitscore:
                     247.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVIRGRERFLTKLYAFVDFAMMQGAFFLAWVLKFKVFHNGVGG
                     HLPLEDYLFWSFVYGAIAIVIGYLVELYAPKRKEKFSNELAKVLQVHTLSMFVLLSVLF
                     TFKTVDVSRSFLLLYFAWNLILVSIYRYIVKQSLRTLRKKGYNKQFVLIIGAGSIGRKY
                     FENLQMHPEFGLEVVGFLDDFRTKHAPEFAHYKPIIGQTADLEHVLSHQLIDEVIVALP
                     LQAYPKYREIIAVCEKMGVRVSIIPDFYDILPAAPHFEIFGDLPIINVRDVPLDELRNR
                     VLKRSFDIVFSLVAIIVTSPIMLLIAIGIKLTSPGPIIFKQERVGLNRRTFYMYKFRSM
                     KPMPQSVSDTQWTVESDPRRTKFGAFLRKTSLDELPQFFNVLKGDMSIVGPRPERPFFV
                     EKFKKEIPKYMIKHHVRPGITGWAQVCGLRGDTSIQERIEHDLFYIENWSLWLDIKIIL
                     LTITNGLVNKNAY"
     regulatory      19293..19298
                     /gene="istA"
                     /regulatory_class="ribosome_binding_site"
     gene            19293..19940
                     /gene="istA"
     CDS             19308..19862
                     /codon_start=1
                     /gene="istA"
                     /gene_functions="other (smcogs) SMCOG1213:transposase
                     (Score: 205; E-value: 2.5e-62)"
                     /gene_kind="other"
                     /note="IstA"
                     /product="putative transposase"
                     /protein_id="AAR99616.1"
                     /transl_table=11
                     /translation="MITRGKFFMIKEMYERGMSISDIARELGIDRKTVRKYIHSPNPPS
                     KSKRKQRKSKLDPFKPYLQKRMLEDGVFNSEKLFFEIRQQGYTGGKTILKDYMKPFRET
                     AKKKYTVRYETLPGEQMQVDWKEVGEVVIEGRKVKLSLFVAVLGYSRMKYAVFTVSQDQ
                     EHLMECLIQSFKYFGGVPKKV"
     regulatory      19897..19940
                     /gene="istA"
                     /note="putative stem-loop structure"
                     /regulatory_class="terminator"
ORIGIN
        1 agtccggaac aattcgcagg acagttccgc tttctcgatt tgtacttgaa tgaccgcaat
       61 gacgtcgtca aaatgacgct tggccaaccg atggacgtca cggtgaagaa aaacgattga
      121 tgtttttgca caaaatgttt gccaaccaaa accatcaaac tgccaaaata ttgttctaaa
      181 tttctgttac aggcatattc atatcaatgt cgccatcgat ggaaataatt tcaatggcat
      241 attctctaaa aaatttgtat ttagggctag aatttagaaa gaaaatgtat tattatagaa
      301 gacgtagaac attaaggaat gatgtgaaag tgctagcact gaatgatagc cttgctaata
      361 agtctatcat ctggacacac aggatgatct tggttcatgt tagcaccttt taggcaatga
      421 atctactaaa cggcagccgt ttaggatcat tgtcttaaag tttcataaaa acgaaggggg
      481 attttaggct ttatggacaa aaagaaagca gtcaaacttg ccacagccag cgctgtagca
      541 gcgagcgctt tcgtcgccgc caacccgcac acttcccaag cagcaacgga cgtggcgacg
      601 gtcgtcagcc aagcgaaagc gcaaatgaaa gaagcatact atacgtacag ccatacggta
      661 acggaaacgg gccaattccc ggacattaaa gatgtatatg ccgcctacaa caaagcaaaa
      721 caagcgtatg caaacgctgt cgctgttgtg aacaaagccg gcggcgcgaa aaaagacgcg
      781 tatttggctg acttgcaagc tacatacgaa acgtatgtat tcaaagccaa cccgaaatcg
      841 ggcgaagcgc gcgtggctac gtacatcgac gcttacaact atgcgacaaa attagacaaa
      901 atgcgccaag aactcaaagc agccgtcgat gcgaaagatc tgaaaaaagc agaagagctc
      961 taccacaaaa tttcgtacga gctcaaaacg cgcacggtca ttctcgaccg cgtctacggc
     1021 caatcgacgc gcgaactcct ccgttcgacg ttcaaagccg atgctcaagc attgcgcgac
     1081 agcttgatct acgacatcac cgttgccatg aaagcgcgtg aagcgcaaga cgctgtcaaa
     1141 gccggcaact tggacaaagc gaaagccgcg cttgaccaag tcaaccaata tgtatcgaaa
     1201 gtaaccgatg cgttcaaagc cgaactgcaa aaagcagcac aagacgccaa ggcggcgtat
     1261 gaagcggcgt tgcctccaaa agtggaaagc gtcacagctg ttaatgcaaa aacattggaa
     1321 atcaagttta acaaagcggt tgatgccgca acagtaatcg acaacaaagg cacaagcgac
     1381 acgtccgatg acgtcgtgaa agcgaccgcc ataacgctca aagccattga tgatcaagta
     1441 ccggtttcca ctgtgaaagc atcgttgagc gatgacaaga aaacgttaaa attagtggtt
     1501 gatggcgctc aatttttcac gaaacgctat gttgtcgaca ttaaaaacgt caagacattg
     1561 gacggcaaag acgtacctgc ctacacgacg acgatcgaca ccactgattc ggtaagaccg
     1621 agcgttctat cgttctctta cgcggacaac ggcttgacgc tgaaagtgaa gttctctgaa
     1681 ccgcttgcca gcgtaggaac agtcaaactg tacgacggaa caactgaaat ttcggtttct
     1741 ccgaagttca cggctggcga cgatgaaatg acaatcaacc ttgcatcttc gtctgtgccg
     1801 gttaataaag atctgacgtt gaaaatcttc ggtgctgtcg attacaacgg taatgtgatc
     1861 aatccaaacc cagctgaatt gacagtcaag aagacaacgg ttgatataac gaaaccagtc
     1921 gttcaaagca tcgaagcggt caacacgaaa accgtcaaag tgacattcag cgaaaaactg
     1981 ttgagcgctc cgaccatcaa aatcggtggc caaacagctt ctgtttcggt tgattcaacc
     2041 ggcttagtct acacggcaac gttggcttct gctttgtcga aaggtgtgta cgcagttgaa
     2101 gtaagcgatt ataaggactt ggcgggcaat agcggggatg cgtacacgaa agttgttcaa
     2161 ttgaaagccg ataacacagc gccgaaattc gtcagcagcc aagttgtgaa aattaacggt
     2221 gttgagcatc ttgtgctgac atttgacgaa gaggtcacga ctggcagcaa cattacagtc
     2281 gttcaatcga gcgataagta tattgacgaa aacaatgtac ttaaggctgt cggcgcagat
     2341 ttgaaaacaa ctagcgacaa tttcaaatta tatctgccga cagacggaaa atcgaaatcg
     2401 gttgctttga acatttcttc cttgccaaaa ggcacataca ccgtgacgct gccgaacggt
     2461 ttagtaagcg atttggctga caacccatat gccgagcgta aacaaattac gttcgttcgc
     2521 ggctctgaca gcttaacgac gaagccagct cttgataaag actacgatag taatggtgtg
     2581 aaagcggaca acaacaacga attagtattt gcgttcacac aaaacttgga cgcttctgca
     2641 ttgaacctgt ccaacttcaa catcaacggt ttgaccgtca cgaaagcagt ctttgatgga
     2701 gatacgaaac atatccgcgt gacgctcgca cccggggcaa atacgtggac aggcacgcac
     2761 gtcattacga tcagcaacat taagaatacg tctgggctcg ttatggatac cgtgaccgta
     2821 aatgaataca tgaaagaaaa cgtggctccg acgttcacag cgaccttaac cagcgcagac
     2881 gtcatccgtg tcgacttcag cgaaccggtg gcaaatgcga cgatcagtag agcactttct
     2941 gctaacaact ttatcgtaaa agtcgatggt aatgttgtca ctgtatcgaa tgtttacgaa
     3001 gacaacaatg ctactaactt agtacagggt tcgaaagggt acaaaacggt ttatctgaaa
     3061 ctgcagtctc ctgtgaccga cttgtctaaa ccgattacgc tgtccgcaac tgacattgtg
     3121 gatgtgaatc aaacaggcgc gattaccgat aataatgtag ttggcaacaa tgtttctgct
     3181 actgttgtaa acgtagcaaa ataaggatgg agtgtatagc aatgtagcaa ccctcccatg
     3241 aaagtggcga actcactttc atgggagggt cttttgtgat attttttcgt ttatcaccac
     3301 aacatgcacc ttacacacaa gcaagatgct ttcttgtacc gcacatgtat ccaaaatatc
     3361 gatttgttga tattgcttta tagtgcaaaa tgtactagaa tttacaaata ggaggttgtc
     3421 gatttttgca gaatgaggag aatttactca tgcatggaaa atgggaccga tacgtgtttc
     3481 ttagtttgct agttttgatt ttatcgggaa tcagctatgc tcactggaaa ggccaacaac
     3541 aggacgagca gtttctaaaa gactatactg agtatcaaca ggcgattcag ttgatgcaac
     3601 agggacgggc agagcaggct ttgccgttat tgcggtcgtt gctgggcaaa tacccggatc
     3661 gttacaacat catgcgcaca cttggtttgg cgtatgcgat gaaaaatgat tttcagaagg
     3721 ctgcttttta ttacgaaaaa gcgattagaa aaaggccgtt cttgcaacag gatccgattt
     3781 tcacgttgca atttggcgag attctgtatt acaacggtga gtatgcgaaa gctaaagcat
     3841 acttggagca aagcaaacaa ctgcctggat cagaaacgta tcatgctaga atcgatgaac
     3901 tgttgtctca aatccagcat caaaaatcat cataaggtga gaagcgaaca tgtctgattg
     3961 gtataagtat ttaaatattg aacgtgatga acatgaggac caactggata tggaacgggt
     4021 cgatgcgata ttgttttggg ggctggcatt cattgtactg gccattccat tgatcgttag
     4081 agtgcatatt ggcgacttta tcagcccgtc cattacggaa gcggatattt tggatacggg
     4141 aaagaaagca gatgtattta cttattacaa acacatttta ttgctaattt ccactgcatg
     4201 tttaagtcta ttatttatat ataaggttgc tgtactgagg tactctatac caaaaacaaa
     4261 aataaacata tcgttggctt tgttagcgat ctttattact ttgtcggctg tttttgcgcc
     4321 ttataagacg cttgcccttt atgggatgta tgatagaaac gagggaacaa ttacttacct
     4381 ttgctattta atgttgtttt ttatcgctgc gaatattcat tatacagaga agaggctaaa
     4441 atgggcgtta tattgcctat acccgtttgt catgattaac actttgttag gtattgttaa
     4501 tttttatggt tataacgtac tcgagttaaa ctgggtgaaa aaattgcttt actcaaatct
     4561 tccccaaggc gcaaagttga cggaaggttc gcggttaatt gcaaccatta accacggaaa
     4621 ctatgtaagt gggatttcgg ctgttcttac gacccttttc ttcacttggg cattattaga
     4681 taaaaataag atcagaagta tcgtaaattt tgtgatgtct ttactatgtt ttgccatgtt
     4741 gttaagttcg ctttcggtta gtggatttct tacattgact cttattcttc cgattgtctt
     4801 tttatttgtc tttaaatcga tatataagcg taaatttgca gttacttttg ccactttttt
     4861 agtcggagca gcatgtgttt atgttgtaat ggtaaatcat aatccgaaag tatgggatga
     4921 aacgtttggg ttttttataa aaagcaatcc gtttgcagaa gctcgtgctg tagtcgatga
     4981 attgcaacaa gcttttgatg caagtcatgt atatgcggaa acaggatcga atcaagaaaa
     5041 taaggagtat caacttccac aacttcctga atcaggagtt ggtcctggat cgggacgttt
     5101 atacatatgg aaaaaaacgt gggaacttat tcagtatcgt ccattatttg gatacggtct
     5161 tgatacactt ccttactttt tcccacagga tgatcctgaa aagcaagcca atatcgagac
     5221 atatactgtt atagtcgata agccgcataa catgtacatc ggtattgctt acggagctgg
     5281 tgtgattgcc ctgcttgcgt ttgttgcttt cattgtcaac attgggctat tgacaataaa
     5341 acgttttatc agtacgaaat tagttgatga taaacaagct atttttgcaa gcgtcgctat
     5401 cgcttgtggt gcgtatctca ttcaggcgct atttaacgac tctatcatcg gtacagccgt
     5461 aatattctgg atattgcttg gattgttagt ctctttcctt atacaaaata agcaggaaaa
     5521 agtgagttga ttttaaatgg agatgccatt ggtttcgatt gtggttgcta cgtattttcc
     5581 gcgcacagat tttttcgaga aacagttgca aagcttgaat aatcaaacgt acgaaaatat
     5641 tgaaatcatc atctgtgatg atagtgctaa tgatgcagag tatgaaaaag taaagaaaat
     5701 ggtggaaaat attatctcta ggtttccatg caaggtaata agaaatgaaa agaatgttgg
     5761 aagcaataag acctttgagc gactaacaca agaagctaat ggcgattata tttgttactg
     5821 cgatcaagat gatatatggc tttctgaaaa ggtggagcgc ttagtgaatc acatcacaaa
     5881 acatcattgc acactcgtat attctgattt gagcttaata gatgaaaatg atcgtatcat
     5941 tcataagagt tttaagagaa gcaattttag actaaaacat gtccatggtg acaatacttt
     6001 tgctcaccta attaatagaa atagcgtcac aggatgtgca atgatgatta gggctgatgt
     6061 tgcgaagagt gcgatacctt ttcctgatta cgatgaattc gtacatgatc attggttagc
     6121 aattcacgca gctgttaaag gttctttagg atatattaaa gaacctcttg tttggtatcg
     6181 gattcattta gggaatcaga tagggaatca acgtttggtg aatattacaa atataaatga
     6241 ttatattcga catcgaatag aaaagcaggg caacaaatat cgcttaacac tagaacggct
     6301 atcattaaca ctacaacaaa agcaacttgt ttattttcaa attcatttaa cggaagctag
     6361 aaaaaaattt agtcaaaagc cttgtttggg caattttttt aaaatagttc ctctcattaa
     6421 atatgatatt attttatttt tgtttgagtt gatgattttc acagtacctt ttacatgttc
     6481 aatatggatt tttaaaaagt taaaatatta gtctcacgaa tgaggagtta gaaatgcgac
     6541 tattaggtga tataagaagc ttatttttac atagaagttt gattatgcaa ttcatcaaaa
     6601 gagaagtgag aagtcgttat caaggttcat atctgggcat tgtttggtca tttattacac
     6661 cactaatgat gttaatgatt tatacatttg tttttagtgt agtgttcaaa gctcgttggg
     6721 gaacaagttc aggggatagt aaagtggaat tcgcattact cttattttca ggacttattg
     6781 tatttaatat tttttcagaa gttgtatcta gagcgccaat gttaattacg agcaatgtga
     6841 attatgtgaa gaaagtagtg tttcctctag aagtattgcc catagttatc cttggttctt
     6901 ctttatttca tttaggaatt aatatagtga ttttaattat cgccatttta atttttacag
     6961 gaaaaatata ttggactgta atcctgcttc ctttagttct gttacctata tgtctattca
     7021 cattaggatt aggatggttt ttagcatctt taggggtgta tattcgagat attgggcaag
     7081 taatgagtgt agttacatca gctttgatgt ttttaagccc aattttttat cctatttctg
     7141 caataccaaa ggaactacaa tttttatatt atattaaccc aattagttat gttgttgaag
     7201 atgtaagacg tataactgtt tgggggctcc ttccacactg gaattggctc ataattggta
     7261 cggtatttgg tgttattata gcattattag ggttgatatg gttcaagaag acaagaggag
     7321 gttttgcgga tgtcctctga tatagctata aaggtggaaa atttgagtaa gatttaccaa
     7381 atatatgata gaccgattga tcgactcaag caaagtttac ttagaggaag gagaaagtac
     7441 tatcgtgaat ttacagctct caacaatgtt tcgtttcaaa ttcgaaaagg tgaaacggta
     7501 gggataattg gaaaaaatgg atcaggaaaa agtactttac ttcaaatact agccggaaca
     7561 ttgacaccta cttcaggttc tgttgaagta aacgggcgag tagcggcttt gcttgagtta
     7621 ggtagcggat ttaatccaga gtttacggga cgagaaaatg tttacatgaa tggagcgata
     7681 cttggaattt ctaaagaaga gatggatcgg cgttttaatg aaattgcaga gtttgcggat
     7741 attggtgatt ttattgacca accggttaag acatattcaa gtggaatgta tgtgagattg
     7801 gcattttcta ttgctataaa tgtagatgcg gatattttaa ttgtagatga agcgttagct
     7861 gttggagata taaaatttca aatcaagtgt attgataaaa tgaaagaaat aaaaaataaa
     7921 ggaacaacaa ttttatttgt atctcattcc ggtgagcaag taaagaggtt ctgtgacaga
     7981 gctatttggc tgcaacaagg aagtattcgc tatattggtt cttcgagcga ggtagtaaat
     8041 cgatatgaag actcactcca attggaaatg cttaaagatc atcagagaga agtagcggtc
     8101 agcaatgaaa ggattaataa agatttaata aatgaacaag aaactgagtc taatgtagat
     8161 attattgcaa aaatcaattc agttactgta gataaaaatc gtattgaaac gttcgaagag
     8221 ctaatagttt acgttaaata tactatattt gagaatgaag ttccaaactt tttgttagga
     8281 gtagctatat atggaaatga tcgtaaatat atttttggtc ctaatactta tttagataag
     8341 gtagaaattc ctaaaacaaa aggtactcac actataatgt ataaaatacc gaaaattccg
     8401 ttacttgctg gaacttattt tatagatacc ggtattttta ctgatggtgg gctcgtgtgt
     8461 attgattata aaagcgatgt atgtcagttc aatgttgaaa gtaattattt tactgaaggt
     8521 cttgttcata tggaacacga atggagcgtt gtagaatgaa taaaaaaatt ccttttgacc
     8581 aatatcaaag atataagaat gcagctgaaa tcattaatct aattagggag gagaatcaat
     8641 cttttactat tcttgaagtg ggagcaaatg agcataggaa cttagagcac tttttgccta
     8701 aagatcaagt aacttatctg gatattgaag tgccagaaca tttaaaacat atgacaaact
     8761 atattgaggc agatgcaacc aatatgccct tagatgataa tgcattcgat tttgttattg
     8821 ctctcgatgt ttttgagcat attccacctg ataagagaaa tcagttttta tttgaaataa
     8881 atcgagtcgc taaggaagga tttttaatcg ctgccccttt taacacagaa ggtgttgaag
     8941 aaacagaaat ccgtgtaaat gagtattata aggctctgta tggcgaaggt tttcgttggc
     9001 tagaggaaca ccgacaatat actttaccta acctagagga aacggaagat attttaagaa
     9061 aagaaaatat agaatatgta aaatttgaac acgggtcatt attgttttgg gaaaaattaa
     9121 tgcgtctaca ttttttagtg gccgatcgta acgttttgca cgattaccgt tttatgattg
     9181 atgattttta caataaaaac atctatgaag ttgattatat tggaccatgc tatagaaact
     9241 ttatagttgt atgtagagat aaggctaaga gggaatttat tcaatcaatt tatgagaagc
     9301 gaaaacaaaa ctcctatctt aaaaacagta cgatatccaa gcttaatgaa ctagaaaata
     9361 gtatatattc tttaaaaata atagataagg aaaatcaaat ttataaaaag tctctagaaa
     9421 ttacagaaca attattagaa gatctaaaat taaaagagca acaaattata gagaaaattc
     9481 aaacgattaa aaaaaagacg gaaatgatag aattacaaaa tcagaagatt caagagctaa
     9541 agatagagtg tgaaaataaa agtattgaaa ataataatct ttatagtcaa ttattagaaa
     9601 aagagaatta tataaaacaa ttgcaaaacc aagctgagtc tatgcgtatt aagaatagat
     9661 taaaaaaaat attaaacttt agttttatta aatatgttag gaaaatcata aatattattt
     9721 ttaggagaaa gtttaaattt aagttacaac ctgtacacca tttagagtgg agcaatggta
     9781 aatggttggt gttaggtaga gatccgcatt ttattttgaa ggggggaagt tatccaagtt
     9841 catggacgat tattcagtgg agagcatcgg ctaactcatc tgctttatta cgtttgtatt
     9901 atgataccgg gggaggcttt tcagaaaatc aatcctttaa tttaggaaag atagggaatg
     9961 atattaatag agattatgaa tgtgtgattt gtctccctga aaatattcat cttttaagat
    10021 tggatataga gggagagata agtgaatttg aactagaaaa tttaacattc actagcatta
    10081 gtcgtctaga agtattctat aaaagcttca ttaatcattg tagaaagcga aacattaaga
    10141 attataagga attatatagt ttgattaaaa aattatttat ccttgttaga agagaaggat
    10201 taaagtccat ttggtataga gctaaacaaa aactttctat ggaattgtta tctgaagatc
    10261 catatgaagt gtttttaaat gtaagttcaa aagttgataa ggagatagta ttaagtgaaa
    10321 taaaaaaatt aaaatataaa cctaaattct ccgtgatatt accggtatac aatgttgaag
    10381 aaaaatggtt aagaaaatgt atagattcag ttttgaatca atggtatcct tactgggagc
    10441 tctgtatagt agacgataat tcttcaaagg attatatcaa accagtttta gaggaatatt
    10501 ctaataggga tagtagaatt aaaacagtgt ttagaagtaa caatggtcat atctcagagg
    10561 cgtctaatac ggctttagag attgccactg gtgactttat agcgctttta gatcatgatg
    10621 atgaactggc tccagaagcg ctttacgaga acgcagttct tttaaatgag caccctgatg
    10681 ctgatatgat ttacagcgat gaagataaga taactaaaga tgggaaaaga cattctcctc
    10741 tatttaaacc ggactggtca ccagatactt taagatcgca aatgtatata gggcatttaa
    10801 cagtatatcg gacgaattta gtacgtcaat taggtggctt tcgaaaaggt tttgaaggta
    10861 gtcaagatta cgatttagct ttaagagtag ctgagaaaac taacaacatt tatcatatcc
    10921 ctaaaatttt atattcatgg agagaaatag aaacatctac tgctgtaaac ccgtcttcta
    10981 aaccttacgc ccatgaagct ggtttaaagg cattgaatga acatttagaa agagtattcg
    11041 gtaaaggaaa ggcatgggca gaagaaacag aatatctatt cgtttatgat gttcgatatg
    11101 ctatcccaga ggattatcca ttggttagta tcataatacc aactaaggat aatatagaat
    11161 tgctttctag ttgtattcag agcattctag ataaaacaac ttatcctaac tatgaaattt
    11221 taattatgaa taataactct gttatggaag aaacatatag ctggttcgac aagcaaaagg
    11281 aaaacagtaa aattaggatt attgatgcaa tgtatgaatt taattggtcg aaattaaata
    11341 accatgggat aagagaagca aacggtgagg tttttgtgtt cttgaataac gatacaatag
    11401 ttatttctga agattggtta caacgtttag tagagaaagc cttaagggag gatgtaggaa
    11461 cagttggtgg tcttctatta tatgaagata atactatcca gcatgctggt gttgttatag
    11521 gtatgggagg atgggctgat catgtatata aaggtatgca ccctgtacat aatacctctc
    11581 cgtttatctc gccagtaatt aatcgaaatg ttagtgcttc tacaggagct tgtttagcaa
    11641 ttgctaaaaa ggttatagaa aaaataggtg gatttaatga ggaatttata atttgtggca
    11701 gtgatgttga aatttcatta agagctttaa aaatgggcta tgtcaatatt tatgatccat
    11761 atgtacgttt gtatcattta gaatcaaaaa cgagggactc attcattcca gaacgtgatt
    11821 ttgagctttc ggctaaatat tacagtcctt acagagaaat cggggatccg tattacaatc
    11881 agaatctatc atataaccat ttgattccaa caataaggtc gtgaaattat gcttcaaaaa
    11941 ttaatacaga tattaagaag aaatgaatat gtaaagaatg tatataagaa tactgtttcg
    12001 aattttatag aaaccagtat acctgagata acacctttta atgcaagaac aagtagtatt
    12061 aaaggcaaac ggttgaattt gttagttcca tctatcaatc aagagcacat gtttggtgga
    12121 atttcgacag cactcaagct ttttgaacaa tttgataata aaaagtttaa aaaaaggatt
    12181 atattgacag atgctactcc gaatccaaag gacttacaaa gtttcaaatc ttttaaatat
    12241 gttatgccag aagaagataa agattttgca ttacagatag tcccttttaa cgatcgctat
    12301 aacagaacta tccctgttgc taaacacgat atttttattg cgactgcatg gtggactgct
    12361 tacgctgcac aaagaatagt gagctggcaa tcagatacgt atggtatacc tccaaataaa
    12421 atattatata ttattcagga ctttgagcct ggtttttatc aatggtcaag ccagtatgtg
    12481 ttagctgaga gcacctataa ataccgtggt ccacagattg ctgtttttaa tagcgaatta
    12541 ttaaaacaat actttaataa taaaggttat aattttacag acgaatactt ttttcaacca
    12601 aagataaata ccactttaaa aaattatata aacgataaac gacaaaagga aaaaattatt
    12661 ctggtttacg gtcgaccatc tgtgaaaaga aatgctttta cattaattgt tgaagcatta
    12721 aaaatatttg ttcaaaaata tgatagaagc aatgaatgga aaattatttc tgtcggagaa
    12781 aagcataaag atatagcttt aggtaaaggg atacatttga attcattagg taaactcact
    12841 cttgaagatt atgctgattt attaaagaga tcttccatag gtatttcatt aatgatatca
    12901 ccacatccaa gttatccacc attagaaatg gctcattttg ggttgcgtgt aataacaaat
    12961 aaatatgaaa ataaagattt gtccaattgg catagcaata ttgtaagtct agaacaactt
    13021 aatccggaaa atattgccga aactcttgta gaactatgta tgagttttaa taatagagat
    13081 gttgataaaa aggaaagtag caatatgatg ttttacatca atgagtttaa tgaattttct
    13141 tttataaaag aaatcgaaga aaaactttaa aaatgatgac tctattcgta ggtttatttt
    13201 tagtttttaa aagattatat ttttatagtt atggtctcac tgatctcttt atataagtgc
    13261 agattgaaaa atcgacatag gcaaggcttt taagttaagt gaaagagcag tcgaaattat
    13321 atatgtcgga aaataaatct gcatttgcat agttaaatta tactcttaaa tagcattacg
    13381 aattgtatgt tgtttttaca ttcaatatag aaaggtaaga taaaaaatga aaggtatcgt
    13441 tctagccggc ggcagcggta cacgtttata tcctttaacc aaggcaatat ctaaacaact
    13501 attacctatt tatgataaac caatgattta ttatccatta tctgttttga tgctcgcagg
    13561 tattcgcgac attcttatca tctccactcc agaggatacg ccgcgttttg aacagcttct
    13621 tggtgatggt agtgacttgg gaatatcttt atcttatgct gttcaaccat cgcctgatgg
    13681 attggcacaa gcttttatta ttggggaaga gtttatcggt aatgatcatg tggctctgat
    13741 tcttggtgat aatatttttt acggtcatgg atttacggcg atgttggagc gagcggcatc
    13801 taggaaaagt ggagccacca tatttggtta caatgtaaaa gatcctgaac gttttggtgt
    13861 agtcgaattc gacaagaatg gtaaagttat ttctattgaa gaaaagccag aaaatccgag
    13921 gtctacctat gcagtaacag ggttgtattt ctacgataat cgtgttattg acatcgctaa
    13981 gtcgcttcag ccttctgctc gtggagaact tgaaattacg gatgtaaata aggcgtattt
    14041 agaacttgga gagcttcatg tggaattgct tgggcgcggt tttgcttggt tagatacagg
    14101 aacacatgaa tcattactag aggcttcgct ttttattgaa acgattgaaa aaagacaaag
    14161 tttaaaagta gcgtgtctgg aagaaattgc gtatcgtaaa ggttacattt cgagagaaca
    14221 gctgctaaaa ttagccgagc tactgaagaa aaatggttac gggcaatatt tgctcgatat
    14281 tgccaatcgg gttagtaaag aaggtgaatt gattgaaaat tattgagact aagtttagta
    14341 atgcctttct tttagagccg aaagtgttcg gtgatcatcg cggctttttt atggaaagtt
    14401 acaatgataa agtttttaaa gagttaggat tcaattacga gtttgttcaa gataatcatt
    14461 ctttatctgt agaagttgga acgttgcgtg ggttgcatta tcaattagaa ccgtatgcgc
    14521 agacaaagtt agttcgtgtt gttcgcgggg cgatttatga tgtcattgtg gatattcgca
    14581 aagggtcacc cacttatggc gaatggcaag ggtttatttt aaccgaatgg aacaagcgac
    14641 agttgcttgt tccgaaggga tttgcccacg gattttgtac gattgttcca aatacagaag
    14701 tgatatataa agtagacaat tattactcac cagagcatga tcggggaatt tgctggaacg
    14761 atccagattt aaagattgat tggcctactc attctcctat tttgtctgaa aaagacagta
    14821 agcatcctag gctggcagaa gcagaaaata atttcactta ttaagggaag gaaatgcaga
    14881 tgaaagtatt gattaccggc ggagcaggtt ttattggcag taattttgtc aattacatgg
    14941 ttcaaaaata tccaagctat cagattatta atctagatgc acttacatat gcagggaatt
    15001 tggaaaatgt aaaagaggtt gaaaatgagc cgaattatcg atttgtgaaa ggcgatatta
    15061 cggatcggga attgattgaa tcattgtttg cagaaggtat cgatgcggtt gtgaattttg
    15121 cggctgagtc gcatgtagac cgtagtattg ctgatccagg aatatttata aagacaaatg
    15181 ttcaaggtac acaagtgttg ctggatgcag cgaaaaagta tggtgtgaaa aaatatatac
    15241 agatttccac tgatgaagta tatggaacat taggagaaac aggatatttt acagaaacaa
    15301 caccgttagc tccaaacagt ccatacagtg caagcaaagc tggtgcagat ttgttagtgc
    15361 gggcgtatca tgagacatac ggattgccag tgaatattac aagatgttca aataactacg
    15421 gtccttatca ttttccagaa aaattaattc cgttgatgat tattaatgcc ttaaacaatc
    15481 aaccgctccc tgtttatggt gatggtttga atgttcgtga ttggcttcat gtggaagatc
    15541 attgttctgc gattgattta gtgttgcacc atgggaagaa cggcgaagta tacaatgttg
    15601 gcggcaataa cgagcgaacg aatatcgaag tagtaaaagc cattttgcgg tacttaaata
    15661 aaccggaatc gctcattacg tttgttgagg atcgccttgg tcacgatcgg cgttatgcca
    15721 ttgatgcgac gaaaatccgt gaagaattag gatggcagcc gaaatatacg tttgaagaag
    15781 ggctaaagca aacgattaat tggtatttag aaaatcgttc ttggtgggaa aacattttat
    15841 caggtgaata caaagaatat tataaaagac aatatggaca gaaattaggg agatcatcat
    15901 gaaaattgtt gttacggggg caaacgggca gttaggtcaa gagcttgtag gacaactgca
    15961 gcaaacgaac gttgagctct attcgtttac aaaaagtgac ttagatatta cgaatgacag
    16021 catagtaaac gaaacgatta caaagattaa gcctgatatc cttataaacg ctgctgctta
    16081 tacaaaagtc gatcaagcgg aaatcgagga agaaacagct tatttagtga atgcgtttgg
    16141 gcaaagaaat ttggcgatag cagcggaaaa agttggggcg aaaatatgtt atattagcac
    16201 agattacgtc tttgatggga cttcgatgac cccttatcga gaatatgatc gaacgaatcc
    16261 actaggggta tacggaaaat caaagtatgc tggtgaagaa ctgacaaaat cattatgttc
    16321 gcgatatttt attgtgagaa cggcatgggt atatggagag tttgggcaaa attttgtcaa
    16381 aacgatgctt cggttagcaa aagaaaaaga agaaatcggt gttgtcaatg accaaattgg
    16441 ctctcctaca tatacggttg acttagctcg ctttattatt gaattagtcc aaactgagaa
    16501 gtttggaatt tatcatgcga caaatagtgg gtcatgttct tggtacgagt ttgccaaagc
    16561 tatttttgaa gaaagtaata ttcatgtgaa agtaaatcca atcacgacgg aacaatttcc
    16621 tagaccggca gcacgtccta aatactctgt gttagacaat tttgcgatga aggtgaatgg
    16681 gtttccaatg ttaagacatt ggcgtgaagc attgaaagaa tttttgaaaa gtgattttag
    16741 gatttgaagt gatatattta caatagatca attatttact ataatccggt tagttaggcc
    16801 ggattatttt tttacaagcg ggtgaaacaa tggatattag cattattatc gtgaattaca
    16861 atacaccgaa actaactgtt gaggcgattg aatcgatctt aaaatctaaa acaaaatata
    16921 gttatgaaat tattgttgtg gataatcatt cttccgatga ttccgtccgt atcctcaagg
    16981 gaaagttccc gaatatagtg gtgattgaaa ataaacaaaa tgtaggattt tcaaaggcaa
    17041 ataaccaagc aataaaattg tcgaaaggac gctatatttt gttgttaaat tctgatacaa
    17101 ttgtaaaaga agataccatt gagaaaatga tagaatttat ggataaaagt aagaaggttg
    17161 gggcgagcgg ctgcgaggtt gttttgccga atggagaatt agaccgggct tgtcatcggg
    17221 gatttccaac tccggaggct tctttttact acttagtggg attggcgaga cttttcccaa
    17281 gaagcaggcg atttaatcaa tatcatctcg gctatatgaa tttgaacgaa ccgcatccaa
    17341 ttgattgttt ggtaggggca tttatgatgg tgcgcagaga ggtgattgag caagtcggat
    17401 tgttagatga ggaatttttt atgtacggcg aagatatcga ttggtgctat cgaatcaaac
    17461 aggcgggttg ggagatttat tattgcccgt ttacaagcat tatccattac aaaggggcaa
    17521 gtagcaaaaa gaaacctttt aaaattgttt atgaatttca tcgggcgatg tttttattcc
    17581 ataggaagca ttatgctaga aaatatccat ttatcgtaaa ttgtttggtt tatacgggca
    17641 tagcagccaa gttcatactt tctgcaataa tcaacacttt tcgaaaaata ggtggttaag
    17701 gtgattagag gaagagagcg gtttttaacg aagctttatg catttgtcga ttttgcgatg
    17761 atgcaaggag cttttttctt agcttgggtg ttgaaattta aagtgtttca taacggtgtt
    17821 ggcggtcatt tgccattgga agattatttg ttttggagct tcgtttatgg cgctattgct
    17881 attgtaatag gatatttagt agaattgtac gcccccaaac ggaaagagaa gttttctaat
    17941 gagttagcga aggtattgca agtacatacg ttgagcatgt ttgttttatt aagcgtgctc
    18001 tttactttta aaactgttga tgtgtcgcgg tcgtttctat tgctatattt cgcgtggaat
    18061 ttgattttag tttctatata ccgttacatt gtaaaacaaa gccttcgcac attaagaaaa
    18121 aaagggtata acaaacagtt tgttttaatt attggtgcag gatcgattgg cagaaagtat
    18181 tttgaaaatc ttcaaatgca tccggaattc gggttggagg ttgttggatt tttagatgac
    18241 tttcgaacga aacatgcgcc ggagtttgct cattataaac cgattattgg acaaactgct
    18301 gatcttgagc atgtattgag ccatcagtta attgacgaag taattgttgc acttcctcta
    18361 caagcatatc ctaagtatcg agaaattata gcagtatgtg aaaaaatggg cgttcgggtt
    18421 tcgattattc ctgattttta tgatatattg ccagcagctc ctcatttcga gattttcgga
    18481 gatttaccaa tcatcaatgt aagggatgtg ccgttggatg aattaaggaa tcgcgtattg
    18541 aagcgttcgt ttgatatagt gttttcattg gttgctatta ttgtcacgtc tccaattatg
    18601 ttgctaattg cgatagggat taaattgact tctcctggtc cgattatttt taaacaagaa
    18661 agggtcggat tgaatagaag gacattttat atgtataagt ttcgctctat gaagccaatg
    18721 cctcagtctg tctcagatac acaatggaca gttgaaagtg atccacgtcg gacgaaattc
    18781 ggagcgtttt tgcggaaaac gagtttagac gagttacctc agttctttaa tgtactgaaa
    18841 ggcgatatga gtatcgttgg tccgcggcct gaacgtcctt tttttgtcga aaagtttaag
    18901 aaagaaattc caaaatatat gattaaacat catgtccgcc caggaatcac cggatgggct
    18961 caagtgtgtg gattacgggg ggatacctcg attcaagaaa ggattgaaca tgatcttttt
    19021 tacatagaga actggagctt gtggctagac ataaaaatca ttttgcttac aattaccaat
    19081 ggtttggtaa ataaaaatgc atattaggtt cttctgtcat ttgatatttg attgggtaag
    19141 tgggaatttt tgtagtgtca ccattttata aaagagtgta tggtagataa cattttgatg
    19201 taactattca ccccatgtta aagccgatga taaaatcccc aatatagccg gaataaaatt
    19261 ccccacttac aatagaacca tagtgtcaac gagaggagct atggttcatg attacgagag
    19321 ggaaattttt tatgatcaaa gagatgtatg aaaggggaat gagtatttcc gatattgcga
    19381 gggaattggg gatcgatcgg aaaaccgtcc gaaaatatat tcactccccc aatcctcctt
    19441 ccaaatccaa gcgaaaacaa agaaaaagca agttagatcc atttaagccg tatcttcaaa
    19501 aacgaatgtt agaagatggg gtgtttaata gcgaaaagtt gttttttgaa attcgacaac
    19561 agggctatac gggaggaaag acgattttaa aagactatat gaaacctttc cgagagacgg
    19621 cgaaaaagaa atacaccgtt cgttatgaaa cgcttcctgg cgaacaaatg caagtcgatt
    19681 ggaaagaagt cggggaggtc gtgatcgaag ggagaaaagt caagttatcg ctatttgtgg
    19741 ctgtgttagg ctattcgcgg atgaaatacg cggtatttac ggtcagccag gatcaggaac
    19801 acttaatgga atgcctgatt cagagcttca agtactttgg cggggttccg aagaaggtgt
    19861 gagtaaaata tttgtgggtg acattcagga atgattcccc gacgagggtt gcgaactttt
    19921 gttcgcgacg ctcgtcgggg ccaccaagcg aagcgcggta gaaaaaagca aatgtcatgc
    19981 aaa
//
