LOCUS       BGC0000811             22152 bp    DNA     linear   PLN 12-MAR-2007
DEFINITION  Aspergillus fumigatus Af293 chromosome 2 afu1_92, whole genome
            shotgun sequence.
ACCESSION   BGC0000811
VERSION     BGC0000811
KEYWORDS    .
SOURCE      Aspergillus fumigatus Af293
  ORGANISM  Aspergillus fumigatus Af293
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Fumigati.
COMMENT     Annotation is on the contigs.
            Annotation was updated in March 2007.
            ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 20:41:33
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 2907011
            Orig. end    :: 2929163
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     mRNA            complement(<1..>1131)
                     /locus_tag="AFUA_2G17960"
                     /note="transcript AFUA_2G17960A"
                     /old_locus_tag="Afu2g17960"
                     /product="NADPH dehydrogenase Oye3, putative"
     gene            complement(<1..>1131)
                     /locus_tag="AFUA_2G17960"
                     /old_locus_tag="Afu2g17960"
     CDS             complement(1..1131)
                     /EC_number="1.6.99.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     332.3; E-value: 5.6e-101)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_2G17960"
                     /note="encoded by transcript AFUA_2G17960A; similar to
                     widely conserved NADPH oxidoreductase containing flavin
                     mononucleotide (FMN), homologous to Oye2p with slight
                     differences in ligand binding and catalytic properties; may
                     be involved in sterol metabolism; Oye3p (GI:6325086)
                     [Saccharomyces cerevisiae]; GO_function: GO:0003959 - NADPH
                     dehydrogenase activity; GO_function: GO:0050662 - coenzyme
                     binding; GO_process: GO:0008152 - metabolic process"
                     /old_locus_tag="Afu2g17960"
                     /product="NADPH dehydrogenase Oye3, putative"
                     /protein_id="EAL94095.1"
                     /transl_table=1
                     /translation="MREEPSSAQLFKPLKVGRCHLQHRMIMAPTTRFRADGQGVPLPFV
                     QEYYGQRASVPGTLLITEATDITPKAMGYKHVPGIWSEPQREAWREIVSRVHSKKCFIF
                     CQLWATGRAADPDVLADMKDLISSSAVPVEEKGPLPRALTEDEIQQCIADFAQAARNAI
                     NAGFDGVEIHGANGYLIDQFTQKSCNHRQDRWGGSIENRARFAVEVTRAVIEAVGADRV
                     GVKLSPYSQYLGMGTMDELVPQFEYLIAQMRRLDVAYLHLANSRWLDEEKPHPDPNHEV
                     FVRVWGQSSPILLAGGYDAASAEKVTEQMAAATYTNVAIAFGRYFISTPDLPFRVMAGI
                     QLQKYDRASFYSTLSREGYLDYPFSAEYMALHNFPV"
     subregion       1..22152
                     /aStool="mibig"
                     /contig_edge="False"
                     /label="Alkaloid"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..22152
                     /contig_edge="False"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            join(<1919..2336,2389..2585,2645..>2902)
                     /locus_tag="AFUA_2G17970"
                     /note="transcript AFUA_2G17970A"
                     /old_locus_tag="Afu2g17970"
                     /product="ergot alkaloid biosynthetic protein A"
     gene            <1919..>2902
                     /locus_tag="AFUA_2G17970"
                     /old_locus_tag="Afu2g17970"
     CDS             join(1919..2336,2389..2585,2645..2902)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 150.5; E-value: 1.1e-45)"
                     /gene_kind="other"
                     /locus_tag="AFUA_2G17970"
                     /note="encoded by transcript AFUA_2G17970A; similar to
                     ergot alkaloid biosynthetic protein A, orfA (GI:57864916)
                     [Claviceps purpurea]"
                     /old_locus_tag="Afu2g17970"
                     /product="ergot alkaloid biosynthetic protein A"
                     /protein_id="EAL94096.1"
                     /transl_table=1
                     /translation="MTILVLGGRGKTASRLSLLLDNAGVPFLVGSSSTSYVGPYKMTHF
                     DWLNEDTWTNVFLRASLDGIDPISAVYLVGGHAPELVDPGIRFINVARAQGVNRFVLLS
                     ASNIAKGTHSMGILHAHLDSLEDVQYVVLRPTWFMENLLEDPHVSWIKKEDKIYSATGD
                     GKIPFISADDIARVAFSVLTEWKSQRAQEYFVLGPELLSYDQVADILTTVLGRKITHVS
                     LAEADLARLLRDDVGLPPDFAAMLASMETDVKHGTEVRNSHDVKKVTGSLPCSFLDFAE
                     QEKARWMRH"
     mRNA            complement(join(<3608..4229,4262..4500,4792..>4947))
                     /locus_tag="AFUA_2G17980"
                     /note="transcript AFUA_2G17980A"
                     /old_locus_tag="Afu2g17980"
                     /product="cytochrome P450 monooxygenase, putative"
     gene            complement(<3608..>4947)
                     /locus_tag="AFUA_2G17980"
                     /old_locus_tag="Afu2g17980"
     CDS             complement(join(3608..4229,4262..4500,4792..4947))
                     /EC_number="1.14.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 146.8; E-value: 1.6e-44)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_2G17980"
                     /note="encoded by transcript AFUA_2G17980A; identical to
                     cytochrome p450 (GI:66853773) [Aspergillus fumigatus Af293]
                     PMID: 15933009 similar to SP:Q12645: Pisatin demethylase
                     (Cytochrome P450 57A1) [Nectria haematococca mpVI];
                     GO_function: GO:0016491 - oxidoreductase activity;
                     GO_process: GO:0008152 - metabolic process"
                     /old_locus_tag="Afu2g17980"
                     /product="cytochrome P450 monooxygenase, putative"
                     /protein_id="EAL94097.1"
                     /sec_met_domain="p450 (E-value: 1.5e-37, bitscore: 118.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MLLLTFTLPVVTLLLAHIIRSWFRLRHIPGPFWAKITDLWREHHY
                     IKGDYGDRPMAPYFAIPSLLGMESAMDQIQQELEDQICRRVTIDVVLWMRLFSLESLHW
                     IAFSNKLGYLSEGKDTDGILSILQSKFIGLAGQLCGWIHRTTLRFHFPKSCTGTAVAPS
                     QRKASHRDLLAHFMDASQKNPETLEERGVLGATISTIFAGTDTTGTSLTFFMYYLIKHP
                     AALARLQEELDSAVRSGNLSYPPKWVEVSTLKYLQAVFKETLRLHSTARMSLYRVVGPE
                     GLDLCGERLPSGTNLGCFGYTAHRNEPIYGRDAALFRPERWIEASNDTLLSMERASL"
     mRNA            complement(join(<5477..5600,5655..>6841))
                     /locus_tag="AFUA_2G17990"
                     /note="transcript AFUA_2G17990A"
                     /old_locus_tag="Afu2g17990"
                     /product="dimethylallyl tryptophan synthase FgaPT1"
     gene            complement(<5477..>6841)
                     /locus_tag="AFUA_2G17990"
                     /old_locus_tag="Afu2g17990"
     CDS             complement(join(5477..5600,5655..6841))
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_2G17990"
                     /note="encoded by transcript AFUA_2G17990A; similar to
                     L-tryptophan dimethylallyl transferase DmaW (GI:32402652)
                     [Neotyphodium coenophialum]"
                     /old_locus_tag="Afu2g17990"
                     /product="dimethylallyl tryptophan synthase FgaPT1"
                     /protein_id="EAL94098.1"
                     /sec_met_domain="dmat (E-value: 5.7e-113, bitscore: 367.6,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MTKTDAQGRHPQETATHAATTDEEVQDQWRAPFEVLSRTLVFQHE
                     DHRLWWERAASKLATYLRLAKYSVGSQYQHLLMFYSVYAPNLGPWPNDKRDNVHWVCGI
                     CPGGENLEISMNYQQGAKCTVRIAAETITPAAGTDKDPFNLTAEKKMIEDLKALQPNLN
                     FTWFNHFQREVLVPEEVALNNDEIISKVPFKNQRLHGLDLSEGAFMLKSYFMPAIRSAI
                     TGVENTQIMFESIRKLNLKNANFISALSTLEDWMVPTNGRFMEYWDGISYDAVDACKAR
                     IKIYTGIRMKSIEHARDVWTLGGRLQGEDIEKGFDLVARLWRRLMDEEPSTCEMKYWMQ
                     WVWELRTDVPFPVPKLYFSVAAAEDHYVSDTVVEILDYLGWDDLVQTHRALMDEAWSLG
                     QTTKSYLAFSYISVTFHSIKGPYITTYGNPSGPRPVF"
     mRNA            join(<7571..8159,8227..>8423)
                     /locus_tag="AFUA_2G18000"
                     /note="transcript AFUA_2G18000A"
                     /old_locus_tag="Afu2g18000"
                     /product="short chain dehydrogenase/oxidoreductase CpoX2"
     gene            <7571..>8423
                     /locus_tag="AFUA_2G18000"
                     /old_locus_tag="Afu2g18000"
     CDS             join(7571..8159,8227..8423)
                     /EC_number="1.-.-.-"
                     /NRPS_PKS="Domain: PKS_KR (9-127). E-value: 5.2e-10. Score:
                     31.3. Matches aSDomain:
                     nrpspksdomains_AFUA_2G18000_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     156; E-value: 2e-47)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_2G18000"
                     /note="encoded by transcript AFUA_2G18000A; identical to
                     oxidoreductase (GI:66853775) [Aspergillus fumigatus Af293]
                     PMID: 15933009 similar to oxidoreductase (GI:4499846)
                     [Claviceps purpurea] PMID: 10071219; GO_component:
                     GO:0005634 - nucleus; GO_component: GO:0005737 - cytoplasm;
                     GO_function: GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor; GO_process: GO:0006563 - L-serine metabolic
                     process"
                     /old_locus_tag="Afu2g18000"
                     /product="short chain dehydrogenase/oxidoreductase CpoX2"
                     /protein_id="EAL94099.1"
                     /transl_table=1
                     /translation="MASVESRIIAITGGASGIGAATCRLLAERGAAVLCVCDISPKNFD
                     DLKISIKKINPSTKVHCATVDVTSSVEVRQWIEGIISDFGDLHGAVNAAGIAQGAGMRN
                     TPTIAEEVDEEWTRIMNTNLNGVFYCTREEVRAMKGLPATDRSIVNVGSIASVSHMPDV
                     YAYGTSKGACAYFTTCVAADAFPLGIRINNVSPGVTNTPMLPQFAPMAKTFEEIEESYK
                     KEGLSLIEAEDVARTIVWLLSEDSRPVFGANINVGACMP"
     aSDomain        7598..7951
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AFUA_2G18000_PKS_KR.1"
                     /evalue="5.20E-10"
                     /label="AFUA_2G18000_PKS_KR.1"
                     /locus_tag="AFUA_2G18000"
                     /protein_end="127"
                     /protein_start="9"
                     /score="31.3"
                     /tool="antismash"
                     /translation="AITGGASGIGAATCRLLAERGAAVLCVCDISPKNFDDLKISIKKI
                     NPSTKVHCATVDVTSSVEVRQWIEGIISDFGDLHGAVNAAGIAQGAGMRNTPTIAEEVD
                     EEWTRIMNTNLNGV"
     CDS_motif       7601..7672
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AFUA_2G18000_0001"
                     /evalue="1.20E-07"
                     /label="PKSI-KR_m1"
                     /locus_tag="AFUA_2G18000"
                     /protein_end="34"
                     /protein_start="10"
                     /score="24.4"
                     /tool="antismash"
                     /translation="ITGGASGIGAATCRLLAERGAAVL"
     mRNA            join(<9076..9312,9387..9503,9569..9671,9731..9799,
                     9854..10459,10540..>10967)
                     /locus_tag="AFUA_2G18010"
                     /note="transcript AFUA_2G18010A"
                     /old_locus_tag="Afu2g18010"
                     /product="cytochrome P450 monooxygenase, putative"
     gene            <9076..>10967
                     /locus_tag="AFUA_2G18010"
                     /old_locus_tag="Afu2g18010"
     CDS             join(9076..9312,9387..9503,9569..9671,9731..9799,
                     9854..10459,10540..10967)
                     /EC_number="1.14.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 112.8; E-value: 3.3e-34)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_2G18010"
                     /note="encoded by transcript AFUA_2G18010A; contains a
                     Cytochrome P450 domain; GO_function: GO:0016491 -
                     oxidoreductase activity; GO_process: GO:0008152 - metabolic
                     process"
                     /old_locus_tag="Afu2g18010"
                     /product="cytochrome P450 monooxygenase, putative"
                     /protein_id="EAL94100.1"
                     /sec_met_domain="p450 (E-value: 8.2e-35, bitscore: 109.8,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MDFLQRILGILSSEDVAPALFASSISVLFLILSYQVLYPPSKYSA
                     FPTINGTRWLALSNRRILAEFVTDAQGLMRNGLEKYDIFRIISSIGPMTILHPKYTDEI
                     HNDRQLNFMAVLAKEMFPNYPGFDLFREGTDGSTVLQDAVKFGSSRCLGKSTQLLSDET
                     STLLQKLWGDEPEWHEVTAKSSVHDIIAHLSALLFYGPELCSHKEWLEVTDEYASVGFL
                     AARQLRLWPPILRPIAQWFLPACRRLRYLASRTRGLIEPVIAARQKEKAICYSHGRQPP
                     VYDDAIEWTERAAKGRPYDAAMSPLLFSINALHTTTDLLTQVILDLSTQPDLIVALRQE
                     ILSVKPQQNGWKNASLNQLLLMDSAIKESQRLKPTESILMRRYAMDDLTLADGNKIPKG
                     TVLGIPIFGMRDPKIYVDPDMYDGYRFQKMRDKPGFENKCQLVSTSPWHLGFGHGIHAC
                     PGRFLAAVQVKIILCYIVAKYDFKLAGGAPPKVQSVGIELISDTEARLAVRRRQEMVIG
                     LE"
     mRNA            <11815..>13299
                     /locus_tag="AFUA_2G18020"
                     /note="transcript AFUA_2G18020A"
                     /old_locus_tag="Afu2g18020"
                     /product="O-acetyltransferase, putative"
     gene            <11815..>13299
                     /locus_tag="AFUA_2G18020"
                     /old_locus_tag="Afu2g18020"
     CDS             11815..13299
                     /codon_start=1
                     /locus_tag="AFUA_2G18020"
                     /note="encoded by transcript AFUA_2G18020A; similar to
                     GB:BAC65217.1: trichothecene 3-O-acetyltransferase
                     [Fusarium sp. IFO 7772]"
                     /old_locus_tag="Afu2g18020"
                     /product="O-acetyltransferase, putative"
                     /protein_id="EAL94101.1"
                     /transl_table=1
                     /translation="MKKQVTFKPFRLSPVDHSLPKVYIFKSLYFRGVDDTGSLSRLQDG
                     IDRLISCLPFLSGEVVPCADIPDKVGVLQVQMPCPSLQEIPMLLVKSYPNHTWPAASTS
                     ERWRNTALLDQSYRPLPDFIPPSKPRPVLRFQANFLADGLMLCMGYNHSVFDGTGAGNI
                     LEMLADCCRANPNSILALPTNGDIESELRGLLSSPGVAVANASQEAYAINCAHTEVEPE
                     PSSAMLYCWPFLLSSEKIECLQEACNSLLPHIVRLYSGTQSSLINQDTNWPHILSSNDV
                     LTALLAVSIEKAREATGALGHMSRSLAMAVNLRERLKPMPRHYLGNLVTTVWVSHHRPA
                     VKDLETMVLPVPACNRHEIDRDDLLWITHVAFRIRLGLNAINEEHIRGLIHYLHSQDDW
                     EQIGIHFTDPIFISSWRHLKVYELDFGPTIGHAEHFEMDVGTTDGVCVVMPANTRAVGK
                     TKKAPWDIRIVLNPEVLQALIASAIFGWAMVKDAST"
     mRNA            complement(join(<13976..15292,15350..>15595))
                     /locus_tag="AFUA_2G18030"
                     /note="transcript AFUA_2G18030A"
                     /old_locus_tag="Afu2g18030"
                     /product="catalase Cat"
     gene            complement(<13976..>15595)
                     /locus_tag="AFUA_2G18030"
                     /old_locus_tag="Afu2g18030"
     CDS             complement(join(13976..15292,15350..15595))
                     /EC_number="1.11.1.6"
                     /codon_start=1
                     /locus_tag="AFUA_2G18030"
                     /note="encoded by transcript AFUA_2G18030A; identical to
                     catalase (GI:71002918) [Aspergillus fumigatus Af293] PMID:
                     15933009 similar to catalase P; catP (GI:23344117)
                     [Ajellomyces capsulatus] PMID: 11932457 similar to catalase
                     C; catC (GI:13378326) [Emericella nidulans] PMID: 11157957
                     similar to catalase A, breaks down hydrogen peroxide in the
                     peroxisomal matrix formed by acyl-CoA oxidase (Pox1p)
                     during fatty acid beta-oxidation; Cta1p (GI:6320462)
                     [Saccharomyces cerevisiae]; GO_component: GO:0005782 -
                     peroxisomal matrix; GO_function: GO:0004096 - catalase
                     activity; GO_process: GO:0006800 - oxygen and reactive
                     oxygen species metabolic process"
                     /old_locus_tag="Afu2g18030"
                     /product="catalase Cat"
                     /protein_id="EAL94102.1"
                     /transl_table=1
                     /translation="MLIERGLLSIMASKCSGTWSTYKTYTTANGCPFMKPEGPPADGRT
                     LALNDHHLVESLAHFNREKIPERAVHAKGAAAYGEFEVTADISDICNIDMLLGVGKKTP
                     CVTRFSTTGLERGSAEGMRDLKGMATKFYTKEGNWDWVCLNFPFFFIRDPLKFPSLMHA
                     QRRDPRTNLLNPNMYWDWVTSNHESLHMVLLQFSDFGTMFNWRSLSGYMGHAYKWVMPN
                     GSFKYVHIFLSSDRGPNFSQGEQAKDNSDLDPDHATRDLYEAIERGDYPTWTANVQVVD
                     PAEAPDLGFNILDVTKHWNLGTYPKDLPKIPSRPFGKLTLNRIPDNFFAEVEQLAFSPS
                     NMVPGVLPSEDPILQARMFAYPDAQRYRLGPNHHKIPVNQCPMTFNPTLRDGTGTFDAN
                     YGSLPGYVSESQGVNFARPQEHDPKFNAWLSQLSSRPWMQTNENDYKFPRDFYNALPEF
                     RSQEFQDKMVENIIASVAQTRREIREKVYHTFHLVDPELSARVKRGVEKMDASFKQVSL
                     SRL"
     mRNA            complement(join(<16668..16754,16853..16970,17032..>18182))
                     /locus_tag="AFUA_2G18040"
                     /note="transcript AFUA_2G18040A"
                     /old_locus_tag="Afu2g18040"
                     /product="dimethylallyl tryptophan synthase FgaPT2"
     gene            complement(<16668..>18182)
                     /locus_tag="AFUA_2G18040"
                     /old_locus_tag="Afu2g18040"
     CDS             complement(join(16668..16754,16853..16970,17032..18182))
                     /EC_number="2.5.1.34"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /locus_tag="AFUA_2G18040"
                     /note="encoded by transcript AFUA_2G18040A; identical to
                     tryptophan dimethylallyltransferase dmaW (GI:59806087)
                     [Aspergillus fumigatus] PMID: 15870460 similar to
                     GB:AAS92554.1: SirD [Leptosphaeria maculans]; GO_function:
                     GO:0050364 - tryptophan dimethylallyltransferase activity;
                     GO_process: GO:0009821 - alkaloid biosynthetic process"
                     /old_locus_tag="Afu2g18040"
                     /product="dimethylallyl tryptophan synthase FgaPT2"
                     /protein_id="EAL94103.2"
                     /sec_met_domain="dmat (E-value: 6.5e-153, bitscore: 499.1,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=1
                     /translation="MKAANASSAEAYRVLSRAFRFDNEDQKLWWHSTAPMFAKMLETAN
                     YTTPCQYQYLITYKECVIPSLGCYPTNSAPRWLSILTRYGTPFELSLNCSNSIVRYTFE
                     PINQHTGTDKDPFNTHAIWESLQHLLPLEKSIDLEWFRHFKHDLTLNSEESAFLAHNDR
                     LVGGTIRTQNKLALDLKDGRFALKTYIYPALKAVVTGKTIHELVFGSVRRLAVREPRIL
                     PPLNMLEEYIRSRGSKSTASPRLVSCDLTSPAKSRIKIYLLEQMVSLEAMEDLWTLGGR
                     RRDASTLEGLSLVRELWDLIQLSPGLKSYPAPYLPLGVIPDERLPLMANFTLHQNDPVP
                     EPQVYFTTFGMNDMAVADALTTFFERRGWSEMARTYETTLKSYYPHADHDKLNYLHAYI
                     SFSYRDRTPYLSVYLQSFETGDWAVKCQDAACQPTSLPPDLSKTGVYYSGLH"
     mRNA            join(<18683..18756,18804..18980,18995..19100,19206..19715,
                     19785..>20804)
                     /locus_tag="AFUA_2G18050"
                     /note="transcript AFUA_2G18050A"
                     /old_locus_tag="Afu2g18050"
                     /product="FAD binding oxidoreductase CpoX1"
     gene            <18683..>20804
                     /locus_tag="AFUA_2G18050"
                     /old_locus_tag="Afu2g18050"
     CDS             join(18683..18756,18804..18980,18995..19100,19206..19715,
                     19785..20804)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 296;
                     E-value: 1.3e-89)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="AFUA_2G18050"
                     /note="encoded by transcript AFUA_2G18050A; identical to
                     oxidoreductase (GI:66853780) [Aspergillus fumigatus Af293]
                     PMID: 15933009 similar to oxidoreductase (GI:4499843)
                     [Claviceps purpurea] PMID: 10071219; GO_function:
                     GO:0050660 - FAD binding"
                     /old_locus_tag="Afu2g18050"
                     /product="FAD binding oxidoreductase CpoX1"
                     /protein_id="EAL94104.1"
                     /transl_table=1
                     /translation="MSHRILCVAFCVCSLVAVSSIYSPPFNHPIVYSNNAICFQLSTWR
                     IPQLYLAVLIRRFDLSLSTRGVMLAVTVGVGSSQHHSQRSGLSLTFAMTPSMITLLVKT
                     CVISQRTAVGEPHRPGWVWEVGRTEDETCHAHSPRGAPCHQGRIPLYSAAVESVDQIQV
                     AVRFAQRHRLRLVVRNTGHDTAGRSSGSDSFQIHCHRMKQIEYHDNFRALGSDIDRGPA
                     VSVGAGVTLGEMYARGARDGWVVVGGECPTVGAAGGFLQGGGVSSFHSFIDGLAVDNVL
                     EFEVVTAKGDVVVANDHQNPDIFWALRGGGGGTFGIVTRATMRVHLNSPVCVSEVAVSG
                     LRNNSLLWTKGITGLFSILRSFNQQGIPGQFILRPLSKDQVNASLTLYSLNTDDTRRSA
                     ENMLSIRNILESTTLPFTLASRCLPKISDALRKGPDMLPVNYGIITGSVLVSEDLFNSE
                     EGPLHLAKQLEHFPMGPMDLLFTSNLGGNVSANTGKKHRDTSMHPGWRQAAHLINFVRS
                     VSTPTAHEKARSLEELHSVQMRQLYDIEPDFRVSYRNLGDPLESDAAQVYWGPNYKRLL
                     EIKRKWDPEDLFFSQLGVGSEGWTEDQMCKRQQRLQQMLQYLMSSIAQRVYR"
     mRNA            join(<21061..21332,21405..>22152)
                     /locus_tag="AFUA_2G18060"
                     /note="transcript AFUA_2G18060A"
                     /old_locus_tag="Afu2g18060"
                     /product="conserved hypothetical protein"
     gene            <21061..>22152
                     /locus_tag="AFUA_2G18060"
                     /old_locus_tag="Afu2g18060"
     CDS             join(21061..21332,21405..22152)
                     /codon_start=1
                     /locus_tag="AFUA_2G18060"
                     /note="encoded by transcript AFUA_2G18060A"
                     /old_locus_tag="Afu2g18060"
                     /product="conserved hypothetical protein"
                     /protein_id="EAL94105.1"
                     /transl_table=1
                     /translation="MTISAPPIIDIRQAGLESSIPDQVVEGLTKEVKTLPALLFYSTKG
                     IQHWNRHSHAADFYPRHEELCILKAEASKMAASIAQDSLVIDMGSASMDKVILLLEALE
                     EQKKSITYYALDLSYSELASNFQAIPVDRFHYVRFAALHGTFDDGLHWLQNAPDIRNRP
                     RCILLFGLTIGNFSRDNAASFLRNIAQSALSTSPTQSSIIVSLDSCKLPTKILRAYTAD
                     GVVPFALASLSYANSLFHPKGDRKIFNEEDWYFHSEWNHALGRHEASLITQSKDIQLGA
                     PLETVIVRRDEKIRFGCSYKYDKAERDQLFHSAGLEDAAVWTAPDCDVAFYQLRLRLN"
ORIGIN
        1 ttagacgggg aaattatgca atgccatata ttcagcgctg aaagggtaat caaggtagcc
       61 ttctcttgat agcgtgctat agaaagaggc acgatcgtac ttttgaagct ggatgccagc
      121 catgacccga aagggcaggt ctggagtcga gataaagtac ctcccaaaag caatggccac
      181 attggtgtaa gtcgctgccg ccatctgctc cgtcaccttc tctgccgatg ccgcatcata
      241 cccgcctgcc agcaggatag gtgaggattg accccagaca cgcacaaaca cctcatgatt
      301 agggtcagga tggggctttt cctcatcaag ccatcgggag ttggcaagat ggagatatgc
      361 gacatccaat cgccgcatct gggcaatgag atactcaaac tgtggcacaa gctcgtccat
      421 tgttcccatc cccagatact gactgtaggg ggagagtttg acgccgacac gatcggcacc
      481 cacggcctcg ataaccgccc gtgttacctc gaccgcaaaa cgagctcgat tctcgatgct
      541 tccgccccat cgatcctggc ggtggttgca agacttctgt gtgaactggt cgatgaggta
      601 cccattggca ccatggatct ccaccccatc gaacccagca ttgatggcgt ttcgggccgc
      661 ctgcgcaaaa tctgcgatgc actgctggat ttcgtcctca gtcagagctc ggggaagagg
      721 tcccttctct tctacaggca cggcgctact agagatcagg tccttcatgt cggcgagtac
      781 gtccggatct gcggcgcggc cggtcgccca taactggcag aaaataaagc attttttcga
      841 atggactcta gaaacaatct ctctccacgc ctcgcgctgc ggctcactcc atatccccgg
      901 gacatgtttg taacccatcg ccttgggggt gatgtctgtt gcttcggtga tgaggagggt
      961 gccaggaacc gatgcacgct gaccgtaata ctcttgtaca aaaggaagcg ggaccccctg
     1021 tccatcggcc cggaatcgag ttgtcggcgc catgatcatc ctatgttgga gatgacatct
     1081 tcccaccttg agcggcttga atagctgagc agaggacggt tcttctcgca ttgcttctaa
     1141 tccaccaagt acttggaaca cggtgaatgt cgaagctcag tctgaccagt ggaggtatcg
     1201 acgcgaactt ttcaggtcat ggaagtgtgg agtatggtct acaggcttgg aggactttgt
     1261 attgattctg gcatcgataa ctgagcagac aagacgccat tcgggcacaa tttctttctg
     1321 ctggacaatt ctcatacagc catgtcgtcc cccttgccga gccaacgcca ctatttgttt
     1381 atgtgtctat tattcgatat tcacggggaa aggtgagctg acttgtacgt actctgtcta
     1441 ctccaatgcc ctcacctttc ttcagctgca gagccgtgga gcggaactcc ttgcttcccc
     1501 gtttacatac ttgggaattg aaatcaggac ccatatctcc atgacgagtc ttttatcatg
     1561 cacatgggaa atggcggtca gttaaaacat gatcaatact actgttacgc ctttactcca
     1621 atgcaccgat agctaataag aagagctcct ccaccctccc acaaagaggc aagggagagc
     1681 cagaagagac tgagggtggt gggcgaaaac agctccaagc gtatatgtgc tactgtgccc
     1741 aagacttcac cgtactttct caatgtgtga ataatgagga ctagacgaga cactcttaat
     1801 aagagatcat ctaccagaaa gggcgtacgt tactaccaaa ctctgtgtga ttaaatgtac
     1861 acacattctt tcaacaaaca aatttgatcc atcttctata gagtaggcac tccgcaccat
     1921 gactatcctc gtgctgggtg gccgcggcaa aacagctagt cgtctatcct tgttgctgga
     1981 caacgccgga gtccctttcc tggtcgggtc cagttcaact tcgtacgtag gtccctacaa
     2041 gatgacgcac tttgactggc tcaacgaaga tacctggacc aatgtgttcc tgcgcgcatc
     2101 tctagacggc attgacccaa tttccgccgt ctacctagtg ggaggtcacg caccagaatt
     2161 agttgatcca gggattcgat ttatcaatgt agctcgagct cagggtgtca accgcttcgt
     2221 cctcctcagt gccagtaata tagccaaggg aacacactcc atgggcattc tacacgctca
     2281 cctcgattct cttgaggatg ttcaatatgt ggtcttgagg ccgacctggt tcatgggtaa
     2341 gtttccgaaa accacatcct gccggaggtt tgctgagccc cctcctagag aacctcctgg
     2401 aggatccaca tgtcagctgg atcaagaagg aggataagat ctactccgct accggggatg
     2461 gcaagatccc atttatctct gcggacgata ttgcgcgagt tgcgttctct gtactcacag
     2521 aatggaagtc acaaagagct caggagtatt ttgtcctagg tccagagtta ctttcttatg
     2581 accaggtatg ttagaccgtc ttctacgcgc ggcaggatgg tgttgtgctg acggccttct
     2641 acaggtagcg gatatactca caactgttct gggccgaaag atcacccatg tcagtctcgc
     2701 tgaggcagac ttggctcggc ttctaagaga tgacgtcggc ctaccacccg atttcgcggc
     2761 catgcttgct tcaatggaga cagatgttaa gcacggtaca gaggtacgca atagccatga
     2821 tgtgaagaag gtaactggaa gtttgccatg cagcttcttg gactttgcag agcaggaaaa
     2881 agcgcgctgg atgcggcatt aaaggtattt tgggaggaag gaagtccatg atgacgtttg
     2941 atcctctgtg tcaccagcgc tttgatatcc tccataaaga gttagcatac gactcaagac
     3001 gtatgctaac tatctagaaa tagccaaaca agataattct taggctgatg tcattagctt
     3061 atcggctgtt actcattttc cccgttgcag taaccaagtt ttctcaggtt cccactgcga
     3121 tgagtttgac tacagcaggt tctacttctt tttaagttga cgccttcaac ataacaactt
     3181 ccaaataact cgacaatata ttctctattc agaagaacat tcctgagggc acttatcaga
     3241 ctttgctgta aatggtaagc tggtaaatcc tcaggactgc aaatatagac aatggaagcc
     3301 ccgatatctt tcagcccttc tctgggaatc ctaaacattg tttttaacac tgattctctc
     3361 tttgaaagtc atatagtgct catgatccgc atatccagta accgatccag agaggactcc
     3421 cagctcctca tcgacattca cggcagaaat ctatccactg tcagcatgaa caagtctcca
     3481 aggcggaaaa atagatgcac aaatgggatt ctcatatatc aaatcgaatg agtaacctgg
     3541 ctatgagctt cgtgaccatc attctagtga ggttcttccc gatgcaacca tgctttccat
     3601 gtccgaatca aaggctcgcc cgttccatgg aaagcagtgt atcattcgat gcctcaatcc
     3661 atctttctgg tcggaacagc gccgcatcac gtccgtagat gggttcattg cggtgtgctg
     3721 tataaccaaa gcatccgaga ttggtcccag aaggaagacg ctcaccacac aagtccagcc
     3781 cctcggggcc gacaacacgg tacagagaca tgcgtgcagt gctgtgtaat cttagggttt
     3841 ccttgaatac cgcctgaaga tatttaaggg tggacacctc tacccatttg ggtggatagc
     3901 tgagattgcc agagcggacg gccgagtcca gctcttcctg taaacgtgca agggcggctg
     3961 gatgtttgat gagatagtac atgaagaaag ttaggcttgt accagtcgtg tcagtgccag
     4021 cgaagatagt tgatatggtt gctcccagaa ctcctctctc ctcgagagtc tccgggttct
     4081 tttgagaggc atccataaag tgagcaagta aatcccggtg tgaggctttt cgttgtgacg
     4141 gcgcgactgc agttcctgtg cagcttttgg gaaaatggaa tctaagcgtg gtcctatgaa
     4201 tccagccaca taattgacca gccagcccac tataggagtc gtggaaatat agcaagcaaa
     4261 catgaatttg ctttgcaata tggacagtat tccatcggta tcctttcctt cactcaagta
     4321 tcctagcttg ttggagaagg cgatccagtg tagactctcc aaggagaata gtcgcatcca
     4381 cagcaccaca tctatagtga ctctacgaca gatttgatcc tctaattctt gttgaatctg
     4441 gtccatcgct gattccatcc ccagcaaact tggaatggca aagtatggtg ccatcggacg
     4501 cttcaatcag gtgtgaattt cttcgtccta gtcgaaccga ccgagtgtat ttctctgcct
     4561 ctttcgaagg ttgcaacgca aatgtaaaaa ttacccttct tagattagct gctggctgcc
     4621 ataagatatg actacgctga gtgaggttga caagggaatg ctgccctcta cctttttcag
     4681 aatcgggttg gtacgatata tgactggaac acctgacgga tttcccagat tgacagaatt
     4741 agggccagtg cgtactaggt ctccttagcg tttatgaagg gtcagaagca catcgccgta
     4801 gtcgcccttg atatagtggt gctcgcgcca tagatcggtt atctttgccc agaaaggtcc
     4861 agggatatgt ctcaaacgga accagctccg aatgatgtga gcaagtaaaa gcgtcaccac
     4921 tggtaacgtg aatgtgagaa ggagcatttt ggtagaagct ggttctgaag cgaatcccta
     4981 catcaggtta tatggtatgt gtagcctcaa attgaacagc aggggtactg aaccatcgtc
     5041 agctggggga cgcatatact tttgaaatcg tacactggca ggaaggtcaa ggaagtcaga
     5101 tgtatgttca gagcgtacgc aagggacctg ctgtgtaaca ggctctccgg accttctaaa
     5161 aatgctctgt tgccaatatt caagcctaaa aagggatttt gcaccaatac cttggtctcg
     5221 tccggttttc acgtcaatga gacagtgaag caactcctct agagaaaaga taagtgcatg
     5281 caccgttgtt acctgaatat tacgtagtag actgtctgag tgtactatgc gactccttcc
     5341 cctatcagcc agggtaggcg tagttattct gggttgggct agatcaggta atacaatgta
     5401 attcacagcc caagcaacca tttcaaagat aatgctgttt tcattcctga aatactaata
     5461 ttcctctgca tatctatcaa aagacgggtc gtggcccgct ggggttgcca tatgttgtga
     5521 tataaggacc tttgatgctg tggaatgtaa cggagatata gctgaaggca agatagctct
     5581 ttgttgtctg gcccaaagac ctaacaacag tcagtttgga caatacagtt gctccttctc
     5641 tgaaataagc ttaccaggct tcgtccatca aagctcgatg agtctggaca aggtcatccc
     5701 aaccgaggta gtcgagaatc tcgacaactg tatcggagac atagtgatct tcagctgctg
     5761 caacactgaa gtatagctta gggacaggaa aaggaacatc agttctcagc tcccataccc
     5821 attgcatcca gtacttcatc tcgcaggtcg atggctcttc atccatcagg cgtctccaca
     5881 gccttgccac aagatcaaac cctttctcga tgtcttcgcc ctggagccgc cctcccagcg
     5941 tccagacatc acgggcatgc tctattgact tcatacgaat tccagtatat attttgatcc
     6001 tggctttaca tgcatcgacc gcgtcatagg aaataccatc ccaatactcc ataaaacggc
     6061 cattcgttgg aaccatccag tcttctagcg tactcagagc ggagataaag ttggcattct
     6121 tgagattcag ctttcggata gattcgaaca tgatctgtgt gttctcaacc ccagtgatgg
     6181 cggagcgaat cgcaggcatg aagtaggact tcaacatgaa tgctccttca ctcagatcga
     6241 gcccatggag tctctgattc ttgaatggga ctttggagat aatttcgtca ttgtttagag
     6301 ccacctcttc cggcaccaga acctcccgct gaaaatgatt aaaccaagtg aagttcaggt
     6361 ttggctggag ggccttaaga tcctcgatca tcttcttctc agcggttagg ttgaaagggt
     6421 ccttatcggt accggccgcg ggtgtaatgg tttcagcagc gatgcgaact gtgcatttcg
     6481 ctccttgttg gtagttcatg ctaatctcca ggttctcgcc tccagggcag ataccgcaga
     6541 cccagtgaac attatctcgc ttgtcgttgg gccaaggtcc caaattgggc gcgtagacgg
     6601 agtagaacat caacagatgc tggtactgag atcccacact gtactttgca agcctaaggt
     6661 atgtggcaag ctttgaagct gcccgttccc accaaagcct gtggtcctca tgctgaaaaa
     6721 caagggtccg actcaatacc tcaaatggag ctctccattg atcttgaacc tcttcgtctg
     6781 ttgttgctgc atgggttgcc gtctcttgtg gatggcgccc ttgcgcgtcg gtcttggtca
     6841 tcgtgttgca gttgttgtgt ggtggaggca agtctctgct tgtttcccag aattattgct
     6901 cccttgagct ggaccaagga ataggtatgt acgtatctac gcagcagtag tatgatcgtc
     6961 tggccactct gcctttaata tcaatcattt ttgccggttc cgcgtacgag atggcgtgtg
     7021 agttgtacgt aggaatagaa acttgcggag cttttcctcc ctacaaggga gcagtacaga
     7081 ggaagcaagg gaaaccaccc ttgccttgtg gaatccggat gacgtcttgc gcattttctg
     7141 gtgccttact gcaatgaaac ggctcaccga cgcctttacg cactatatca gctgttccgt
     7201 ttgagaagca tgtggagcca ggtttaagca atcagcaaca taatacagtc agtctctggc
     7261 gtagcaaaaa ggtttgttga attgatggat gaccagttgc tttgcagcag catacctgtg
     7321 tgaccggaca tttccgtaaa gggggaacgc tgctgtgagc cgaaagtcga cgatttgcta
     7381 gtcaaagcaa ggaggaatta caaaggaatg atgagaaacg aggacaccat ctggagacag
     7441 aaagttccga ccatgaacgg cataaagtct ctcatgagga cagggctttc tttgaaaaat
     7501 gcctagaggt cgataaccaa ttattcctcc agcacaccag cacacaccac ttagagcatc
     7561 ttctctaata atggcatcag tcgaatcccg aataatcgca atcactggcg gcgcctccgg
     7621 cattggtgcg gcgacctgcc gcctgctcgc tgaacgtggc gctgcggttc tgtgcgtctg
     7681 cgatatctcg cccaagaatt ttgatgatct caagatttca atcaagaaaa ttaatccatc
     7741 gacaaaagtc cactgcgcta cagtcgatgt aacctcctct gtggaagttc ggcaatggat
     7801 cgagggcatc atatctgatt tcggagacct ccatggagcc gtcaatgcag ccggtatagc
     7861 tcaaggtgct ggcatgcgaa atacccccac gattgcagag gaggtggacg aagagtggac
     7921 aaggattatg aacactaacc tgaatggcgt gttctattgc acgcgcgagg aggtgcgtgc
     7981 catgaagggt ctgcctgcta cagatagaag tattgtcaac gttggcagta ttgcgagcgt
     8041 ttctcacatg ccagacgtgt atgcgtacgg cacctcaaaa ggagcctgcg cctatttcac
     8101 tacttgtgta gctgcggatg cgtttccctt gggtatccgg atcaataatg tctctccagg
     8161 tgggtcatct ccttcccctt cttcggcatg gaaagctgtc atattgatca caatactctc
     8221 ttgtaggagt cacaaacacg ccaatgcttc cccagtttgc tcctatggcg aagacatttg
     8281 aagaaataga agagtcatac aaaaaggagg ggctatcgtt gatcgaggcc gaggatgtgg
     8341 ctagaaccat tgtttggtta ctaagtgagg actctcggcc ggtatttggg gcgaatatca
     8401 atgtcggtgc ttgcatgccg tagatgaagt gggcatttct ccagtctata ccgtgttgcg
     8461 aacatttcag aaatcaacct ctaggttaga agtgcttttt gcaagaccat ccagtgttat
     8521 tggtggaatt aaccataatg aaaaatagtt gtcgaggcca ttcctccact cttcaggagt
     8581 acgcagggaa tttgacgaca aaaagctgtg ttaatatgta caaagccccc ataaaagcct
     8641 tactgcgttg aggtattttc tctttagcac ctcgtggacc ttgccgttac tgatgtgcag
     8701 attcaacgta accttcgaaa tcccggaatt cctcaaacat tccccgtgtc agatgtttgc
     8761 aatttgtgag atgccatctt ttaactgagt caatataact ccgttccttt agtcaactat
     8821 gctagttttg taaatatcat cctctctaca gaattcttcg cgcaattatt gccgaacgaa
     8881 gctatcgggt cgacgggtaa agtctcacaa gcttactgcc ccttgcactc tgatgtctca
     8941 tcagcagtag gggagaaatg tgtgaaagtc ttacaaatat ggcagaatcc ctacaacgca
     9001 actcatgtct gaagacagaa acagtccacc tagttgcaac gcctgctatg gacagtagct
     9061 aacaactgaa tcatcatgga cttcttacaa cggatcttgg gaattttgag cagtgaagat
     9121 gttgcaccgg cgttgtttgc ctcaagcatc tcggtgttgt tcttgatact ctcatatcaa
     9181 gttctctacc caccttcaaa atactctgct ttccccacga tcaatggcac acgctggcta
     9241 gcactcagca atcggcgaat attggcggaa tttgtgaccg atgcccaggg cctcatgcgg
     9301 aatggcctag aggtgagctg gaattctttg tactcgatca tctccaatac caccgacatc
     9361 cttgatcgct aaagcattcg atatagaaat acgatatctt ccgtattata tccagtattg
     9421 gcccaatgac tatcctgcac cccaaatata cggatgagat tcacaatgac cgacaactga
     9481 actttatggc ggtgctagct aaggtacata tcaagaagcc cgttatgcgg acaagacagg
     9541 atcagccgag ttttaacaat aaacttagga gatgtttcct aattacccgg gctttgatct
     9601 cttccgcgaa ggtacagatg gaagcactgt cttacaggac gccgtaaagt ttggatcctc
     9661 acggtgtttg ggtaggtcag ccagggtaca tttgagcatg tgagaagtga acctagtttg
     9721 acacatttag gtaaatcaac ccaattattg tcggatgaaa cgagcaccct actgcaaaaa
     9781 ctctggggcg atgaaccggg tgggtatcct cgttctccgt actactaccg tggtagctaa
     9841 ctgatgagat cagaatggca cgaggtgacg gcaaaatcct ctgtccatga tatcattgcc
     9901 cacctatcgg ccttgctttt ctatgggcca gaactgtgca gccataaaga atggctggaa
     9961 gttacggatg agtatgcatc cgtcgggttt ctagcggctc gacagctccg tctttggcct
    10021 cccatattac ggcccatcgc ccagtggttt ctcccagctt gtcggcgact gcggtatcta
    10081 gcaagcagaa ctcgtggcct catcgagcct gtcattgccg ctcgacagaa agagaaggct
    10141 atatgttatt cgcatgggcg tcaaccgcct gtttacgatg acgcgataga atggacggag
    10201 cgagctgcca aagggcgccc ctacgacgcc gctatgagtc ctctactttt ctcgatcaat
    10261 gcgcttcaca cgaccactga cctgttaact caagtcattc tcgatctcag tacgcagccg
    10321 gacctgattg ttgccctgcg tcaagaaatt ctctcagtca aacctcaaca gaatgggtgg
    10381 aagaacgcca gcctaaacca acttctgctc atggatagtg ctatcaagga aagccaacga
    10441 ctgaaaccaa ccgagtcaag tatgcatgtc gtgatctata acctctcctt tttccttccg
    10501 aataccgtat tgaggtacca cactaactgc ggtcactagt actcatgaga agatacgcaa
    10561 tggatgactt gacccttgct gatggcaaca aaatccctaa agggactgtc ctgggaatac
    10621 caatcttcgg gatgcgagat ccaaagatat acgttgaccc ggacatgtat gatggatatc
    10681 gatttcaaaa gatgcgtgac aagcctggat ttgaaaacaa gtgccagctt gtctctacga
    10741 gcccatggca tctcggattt ggccatggta ttcatgcatg ccctggtcga tttcttgcag
    10801 ccgttcaggt caagatcatc ctctgctata ttgtcgcaaa atatgatttc aaactggcag
    10861 gtggcgcgcc tcccaaggta caatctgtcg ggatagagtt gatatcggat accgaggcaa
    10921 ggctcgccgt gagaagaagg caagagatgg tgattggatt ggagtaagat ctgagatctg
    10981 tttggttcct attgtcggcc attcagtata atctcttacg acagcacaat atcgtcaaaa
    11041 aaatagcagt ggaaaaccaa ggaagtaacg aagtcaacat gattttttga ttacactatt
    11101 ataccatctt cgatattcta ggctgtacag gcattgctac gtagagcgtt ctgtaatccc
    11161 aatgtgtata tttgggagtg tatacatgtt cctcaccgag aacaactcaa ttccacggtt
    11221 attgtgaaat taaaaaaaag aagggggcga ctatctcctt accgtccagt aagcctattt
    11281 agattcttct tgccaacttc tagtcattat gaagtgatgt aggtctagtg tcatcttgac
    11341 atgggtgtat tcaagtaccg ccctcgaatg gtacacactg ggctcatgtt ggcgagcatg
    11401 cgtatagccg caccgtaagt gatgcaattc attaactata catttctatt tccggcttag
    11461 tcgcttcaac atggttctgc cattgaggga tctatgtaag ggagataggt tatggatgac
    11521 cacgtacttg ctgtgaaatg tctacatctt ttctgcgtct cgatggcttg tcaacttgag
    11581 caagtggcgg tgagctcagc tcgattggag atatcccttc aaagagctgg gaatgttctt
    11641 tggcactgtg agggagactt gacttgtatc tctatttgca acagcaaaag gctgggttga
    11701 ttatcggcgg cagttaccca tacattctct cacacaaggc ctgttattac agacgttgca
    11761 cccaattctg gtgcgcaatt gagaaataat atattgcaaa ttttccctct caagatgaag
    11821 aaacaagtga cttttaaacc cttccgtctg agccctgtgg accattccct gcccaaagtc
    11881 tacatcttca agtcgttata ttttcgaggg gtagatgata ctggcagtct ttcgcgcctg
    11941 caagatggta tagaccgtct aatatcctgc ttgccgtttc tttccggaga agtcgtgcca
    12001 tgtgcggata tccctgataa agtcggggtc ctccaagtgc agatgccttg cccctccctc
    12061 caagagatcc ccatgctcct agttaagtca tatccgaacc acacatggcc cgcagctagt
    12121 acttcagaga gatggaggaa tacggcctta ctcgatcagt catatcgtcc actccctgat
    12181 ttcattccgc cgtcgaaacc tcgacccgtg ctccgcttcc aggccaattt cctggcggat
    12241 ggactcatgc tctgtatggg ttacaatcac tctgtgtttg acggtactgg agctggtaat
    12301 atcctcgaaa tgctggctga ctgttgccgt gccaatccaa atagcattct cgctctaccc
    12361 accaatggcg acatcgagtc cgaactgcgc gggctgttgt ccagtcctgg tgttgctgtt
    12421 gcaaatgcgt cccaggaagc gtatgccatc aactgtgcac acacggaggt agaacccgaa
    12481 ccttcctccg ctatgctgta ctgttggccc ttcctgttgt cttccgagaa gattgaatgc
    12541 ctgcaagaag catgtaacag ccttttacca catattgtac gcttgtacag tgggacccaa
    12601 agttctttga tcaaccagga cacaaactgg ccacatattc tctctagcaa cgacgtgttg
    12661 accgcgttgc ttgccgtaag tattgagaaa gccagggaag cgacaggggc cctgggacat
    12721 atgagcagaa gccttgcgat ggctgtgaat ctccgagaac gattaaagcc gatgccgagg
    12781 cattatcttg gaaatttagt gaccactgta tgggtgtctc atcatcgacc tgcggtgaag
    12841 gacctggaga cgatggtttt acctgtccca gcctgtaatc gtcatgaaat tgacagagat
    12901 gatctccttt ggattaccca cgttgcgttc cgtatccgtc ttggactgaa cgccatcaac
    12961 gaagagcata ttcgcgggct cattcactat ctgcacagtc aggatgattg ggagcaaata
    13021 ggcattcatt ttactgatcc catattcatc agcagctggc ggcatctgaa agtatacgag
    13081 ctcgacttcg gtccaacaat tgggcatgct gagcactttg aaatggatgt cggaaccacg
    13141 gatggcgtat gcgtggttat gccagctaac acaagggctg tcggaaagac caagaaggct
    13201 ccatgggaca ttcgcattgt cttgaatcca gaggtcttgc aagctttgat cgcttccgca
    13261 atctttggtt gggctatggt gaaggatgct tccacgtaac ctttttaaca gcagatggag
    13321 caagtgactt aaaatgatga atgtgtttac ctagactcta cttatttcat cctttcagat
    13381 tagcgtggaa taacttataa gaagtagtgt aagaggccgt gtactgcagc atgaatgttg
    13441 gcatttctct gggtacatca aatcttgctg gagtagggaa tggaagtgat ctttataagc
    13501 attagttaca gtattatcaa acctgttcag aatccagcat attcactata atctaatctc
    13561 attgctggtc ccttttattg tctatggcat tgcaatgata attaactcaa gcttctacat
    13621 taattacttt tacatgaaat gtgcaagtgg tagtcggtga ggtatttcac cacttaatat
    13681 agtatttagt aatacctata cctaatcgaa gccgcacgca gtgcacctat gcacaagggg
    13741 ccatcttcta tagtcatgaa gcatcacatc ctacattctg cagacaaagg gaatgcatgt
    13801 atgtcaagct ttcctagaat actagtttac tgtttgctag gcctaaaaca cagcaaccag
    13861 ataaacaatc tactgctgga aattaaccca catgctgcta ctctacggat gcgtaatagg
    13921 agattgaaat agataggaca ctccggcgac tgccgttgtt ttagtgatga gcacttcaga
    13981 gcctggaaag agagacttgt ttgaaagacg catccatctt ctccacccct cgcttcaccc
    14041 gtgcagacag ctccggatca accagatgga aggtgtggta gaccttctcg cgaatctccc
    14101 tgcgagtctg ggccaccgac gcaatgatat tttccaccat tttatcttga aactcctggc
    14161 tccggaactc aggcagcgcg ttgtaaaagt cccgcggaaa cttatagtcg ttctcgttgg
    14221 tctgcatcca gggcctggat gagagctgcg acagccatgc gttgaacttg gggtcgtgct
    14281 cctggggacg tgcaaaattc acgccctgcg attcggacac gtagccaggc aaagatccat
    14341 agttggcgtc aaaagtgccc gtaccgtcac gaagagttgg gttgaaagtc attgggcatt
    14401 gattaacggg aattttgtgg tggttggggc cgagcctgta gcgctgggcg tctggatagg
    14461 caaacatgcg cgcctggagg atgggatctt ccgagggcag gacgccgggc accatattgg
    14521 aaggggagaa ggccagttgt tcgacttcgg cgaagaagtt atccgggatg cgattcagcg
    14581 tcaactttcc gaatggacgt gaagggatct ttggaagatc cttggggtag gtgcccaggt
    14641 tccagtgctt ggttacatca agaatgttga agccgagatc gggagcttcg gccggatcca
    14701 ccacctgcac attggccgtc caggtggggt agtctcctcg ttcaatggcc tcgtacaggt
    14761 cccgtgtagc atggtcaggg tcgagatcgg agttgtcttt ggcttgttcg ccctggctga
    14821 agttgggtcc gcggtccgag gacaggaata tgtgcacata tttgaaggag ccattcggca
    14881 taacccactt gtaggcatga cccatatacc cactcaagga gcgccagttg aacatggtgc
    14941 cgaagtcact gaactgcagc agaaccatgt gaagagactc gtggttagat gtcacccagt
    15001 cccagtacat attggggttc aggaggttgg tccgagggtc gcgtcgttgt gcatgcatta
    15061 gactcgggaa tttgagagga tcccggatga agaagaaggg aaagttgagg cacacccagt
    15121 cccaattccc ttccttggtg tagaatttgg tggccatccc cttcaagtct ctcattccct
    15181 cggcagaacc tcgctccagc ccggtagtcg agaagcgcgt cacacacggc gtcttctttc
    15241 ccacgcctag cagcatgtca atgttacaga tatcggaaat gtcggcagtc acctgggtca
    15301 atcagcatgt cttcgggaac ttaatgacgc ctccgtagga gatcaatacc tcgaattccc
    15361 cataagctgc ggcacctttg gcgtgcactg ctcgctcagg gatcttctcc cggttgaaat
    15421 gagccaacga ttctaccaaa tggtggtcat tgagggcgag tgtgcgccca tcagccggag
    15481 ggccttcagg cttcatgaac ggacaaccat tggccgttgt gtatgtctta taggtcgacc
    15541 atgtacctga acatttggaa gccattattg acaataaccc acgctcaatt agcataagtc
    15601 aaccggttga ttgtcgatac aatgttcagt cctgaccatt tatgtatgac tacttggtaa
    15661 caagtggttc tcattcaccg ctaaaattcg aatacatgcg cctctctgga ctgggtcttt
    15721 tcagcccttg catcacaagc tctctatcat tgacacctga ccagccggat gcatttactt
    15781 ctccttgcag cacacacgcc tctcagagta tcgccacgcc aaagtggcat gaccaaagac
    15841 aagtaatggc tgaccaagtt ggcttccacc gtcttttcag atccctagcg tttatcctta
    15901 gcgctgaggc acatgcaagc ccttacatcc agcaacgtca agacgatgat actctgaaca
    15961 ttccaccaat attcctgggc agccccacct ctgctgcaat ggctatcaac ccctgtatgg
    16021 cagtatccgt ggaggagtcc ggttgaacag aaacgccatg gctgttgggg agatgcgtag
    16081 aaggtttaag taatacctac gggcttccaa gctcggaacc tgatgtgttg taatgacgga
    16141 ttgttgcgag tcgcacatct aggcgctgac tactgacagc cgacattcct atccttgaat
    16201 tatttgactt ccaaacagat tagcgtaaac accacctccc tttagcgatg aaaccgatat
    16261 gattatctta gtgttctgga gtagaccatc atcaagtatt gaagtctgtc tttatggctc
    16321 tgaggtgttt atggcctctg ttagagagct acttgacata ttgtgtcggc aggtgcgcaa
    16381 gggacggtga aacaatatgc atctttattg cgcctctaga ccattatttg cttcaaatat
    16441 aacggatctc ttatcttggg cttttcagag cagagaaaac aacgaaagtc tgacggcatc
    16501 atgtcttgat cggagtcctg caatattagt agcaaagaca gactagggtt cactccttgc
    16561 gtctacaact tggcatcacg acgatacatg aaatttaagt gctagagtct gggtacctcc
    16621 gcgggtgtca tcgggttaca gcccggaagt aagtcccgag ctgttcatca gtggagaccg
    16681 gaataatata cccctgtctt tgacagatct ggaggtaaag atgtgggttg acaggccgca
    16741 tcctgacact tgacctttga ttcggataag tttgctggtg tattgtcagg atgacatcca
    16801 taataaggga gccaatgaac gtcttgtttg ggaggtaaat cggcttacca actgcccagt
    16861 cccctgtctc gaaggattga agatagacac tcagataagg ggtacggtcc ctgtaggaga
    16921 aggatatgta ggcgtggagg tagttaagtt tgtcatgatc cgcatggggg ctgaaaggcg
    16981 catcaatccg ttgctccaca aatacatcat cagaaagaaa ggtctactta ctagtacgac
    17041 ttcaaagtag tttcgtaggt gcgggccatt tcactccaac cccggcgctc gaagaacgtc
    17101 gtcagggcat ccgccaccgc catgtcgttc atgccgaagg ttgtgaaata tacttgcggc
    17161 tctgggaccg ggtcattctg gtgcagggtg aaattggcca taagcggcag cctctcgtct
    17221 gggataaccc cgagaggcag atacggcgcc ggataggact tcaatcccgg cgacagttgg
    17281 atcagatccc aaagctcacg caccagagag agcccctcta aagtggaagc gtctcggcgc
    17341 cgtccgccca gagtccacag gtcctccatg gcttctagtg aaaccatctg ctccagcagg
    17401 tagatcttga ttctcgactt ggcaggactg gtcagatcac aggacactag gcggggactg
    17461 gcagtgctct tggaaccgcg tgatcggatg tattcctcca gcatgttgag tgggggcaag
    17521 attcggggct ccctcactgc cagccggcgg actgagccaa agaccaactc atgaattgtc
    17581 ttgccggtga cgacagcttt gagagccggg tatatgtacg tcttaagtgc aaagcggcca
    17641 tccttcagat cgagcgcgag cttgttctgc gtcctgatag tgccgcccac gaggcgatca
    17701 ttatgagcca gaaaagcaga ttcttcactg ttgagggtga gatcgtgctt gaagtggcgg
    17761 aaccactcca gatcaatgct cttctccagt ggaagcaggt gctgcaggct ctcccagatg
    17821 gcgtgcgtat tgaatgggtc tttatctgtt ccggtatgtt gattgatcgg ctcgaatgtg
    17881 tatctcacta ttgaattaga gcaatttagg ctcaattcga acggagtgcc gtatcgagtg
    17941 aggatgctca accagcgggg ggcgctgttg gtcggatagc atccgagact gggaattacg
    18001 cactccttat aggtgatgag gtattgatac tgacaaggtg tggtgtagtt ggcagtttcc
    18061 agcatttttg caaacatcgg ggcagtgctg tgccaccaca gcttctgatc ttcattatcg
    18121 aatctaaagg cgcgactaag aactcgatag gcctccgcac tggaggcatt ggctgccttc
    18181 atgagagtca tcttggataa gggcatatgc gttggtactc tttatggtgt taaggacggg
    18241 cagcacctaa tataccatgc catgataata ctgctggttc acagttgccg gtccggcatg
    18301 attctttgtg cattggtggt cgtgtatcct tcatgtaagg gtttgacttg gtacaggcca
    18361 cattccaatg aacgaacctt tccttatact tatctgcgat aactagagat ggaacgatct
    18421 ggccgcaata attcagcctc gcttattcca aggtcatcag gccctatcgt ctcactggag
    18481 cagctggttc ttctgtagca tgggtatcct tacttcaact cacaggacaa tggagtagtt
    18541 aacaggtttt tgatgtcatc tctgtcaggg ttaaatatca ctggccatgt tgtggcggaa
    18601 caacttgtga tggaccaaga ttgatatgct tgttgatttg tttttccttg catctgatct
    18661 attccatatc ttagaattcc ttatgtcaca tcgtatcctt tgcgtcgcct tctgcgtttg
    18721 ttctcttgtt gctgtgagct cgatttatag ccccccgtaa gctgctagcg tttcgaagaa
    18781 cgtaaatcaa aacgagatta taggtttaac catcccattg tctacagtaa caatgccatt
    18841 tgttttcagc tttctacttg gcgcattcct cagctgtatt tggctgtcct tatcaggagg
    18901 ttcgacctgt cgctgtcgac caggggagtc atgttggccg tcaccgtcgg agtgggcagc
    18961 tctcaacacc actctcagag gtgatttagt cgaggtccgg cctatcgctc acatttgcca
    19021 tgaccccttc tatgatcact ctgcttgtca aaacttgcgt gatctcgcaa aggacagcgg
    19081 ttggagagcc tcacaggccg gtatgttcat tcgtctactc ggtcatttcc ttgacaccca
    19141 tccccatagc ggcatgttga ctgattgccc gaatctggcg aggtgacaca ctaggtacct
    19201 tacagggctg ggtttgggag gttggtcgca ctgaagacga gacatgtcat gcgcattctc
    19261 cgcgtggtgc gccctgtcat caaggccgga ttccactgta ttcggcggca gttgagtctg
    19321 ttgaccaaat tcaagtggcg gtgaggtttg cgcaacgtca tcgactgcgc ttggttgttc
    19381 gcaataccgg tcatgatacc gcgggacgat cgagtggctc cgactcgttc cagatacatt
    19441 gccatcgcat gaagcagatc gagtatcatg acaacttccg ggccctcggc tccgatatag
    19501 accgtggccc agccgtgagc gtaggcgctg gagtgactct gggggagatg tatgcaagag
    19561 gtgcccgtga tggatgggtg gtcgtcgggg gggagtgtcc taccgtgggc gctgcgggcg
    19621 gttttctcca gggaggcgga gtgtccagtt tccacagctt catcgacggt ctggctgtag
    19681 ataatgtcct cgaatttgag gtcgtgacgg cgaaggttgg tagatacatc cttgataact
    19741 tgcaatatgg tgtctttgta ctgaagttca ctatggctgt gtagggagat gttgtcgtgg
    19801 ccaatgacca ccagaaccca gacatcttct gggctttacg gggagggggt ggaggcactt
    19861 tcggcatcgt tacacgtgct acaatgaggg tgcatctcaa tagcccggtc tgcgtctcgg
    19921 aggtggcagt atcagggctc cggaataact cgttgctctg gacaaaaggg atcacgggtc
    19981 tattttccat tcttcgctcg ttcaaccagc aggggatacc gggccagttt attcttcgac
    20041 cgctatccaa ggatcaggtc aacgcaagtc tcacactgta ttccctaaac acagatgaca
    20101 ctcgacgatc ggccgagaac atgctctcca ttcgaaatat cctcgaatct accacccttc
    20161 ccttcactct ggcctccagg tgcctaccaa agatcagtga cgcgctccga aaaggacctg
    20221 atatgcttcc cgtaaattac ggaatcatca ccggctccgt tttggtgtca gaggatctct
    20281 tcaattcgga ggaaggacca ctgcatctgg ccaagcagtt ggaacatttc ccgatgggac
    20341 cgatggatct cctgttcacc agcaacctcg gcggaaacgt ttcggcaaac accggaaaga
    20401 agcacaggga tacctcgatg catccgggct ggcggcaagc ggcccacctc atcaacttcg
    20461 tgcgcagtgt gagcacaccc acagcgcatg agaaggccag aagcttagaa gagcttcata
    20521 gcgtccagat gcggcaactg tacgacattg aacccgactt cagagtgtcg tacaggaatt
    20581 tgggcgaccc tctggaaagt gatgctgcac aggtctactg gggcccaaat tacaagcggc
    20641 tgctggaaat caagcggaag tgggaccctg aggacctgtt tttctctcag ctgggggtgg
    20701 gaagtgaggg gtggacagag gaccaaatgt gtaagagaca gcaaagactg cagcaaatgc
    20761 ttcagtatct aatgtccagc attgcccagc gggtataccg ctaagtgcag atgttcctct
    20821 gactggatgg tcgtgctgca catggctgta agggatggtc ggtcagatat tggactgtgg
    20881 taagggcaat agcagtacag tcaacagcag taacacattt gacaatactt tacaatcaag
    20941 atgtatgtag ataaaggaaa gaatggggga aaaactcaaa ggaggtagac aaagatgctc
    21001 tctatatcat cgttgcccac cagaccatca tattcttctt tagactaaga atcagccacc
    21061 atgacgattt cagctcctcc cattattgat atccggcaag cggggcttga aagctcaatt
    21121 cctgaccaag ttgtcgaagg tctcacgaaa gaagtgaaaa ccctcccagc tctacttttc
    21181 tacagcacga agggaattca gcactggaac cgccactccc atgctgccga cttttatccc
    21241 cgacatgagg aactatgtat tctgaaagcc gaggcttcaa agatggcagc atctatagcc
    21301 caggatagtc tcgtcataga tatgggcagc gcgtaaggac atgtttcctc cggttcagcg
    21361 agtcaatagt aaatagaagg gcgctgacct tcatcctctt acagaagtat ggacaaggtc
    21421 atcttactgc ttgaggcgct tgaagagcaa aaaaaatcca ttacatacta cgcccttgac
    21481 ctcagctact ctgagttggc ctcgaacttt caggccatac ctgtggaccg cttccattac
    21541 gtccgttttg ctgccctcca cggcacattt gacgatggtc tgcattggct tcagaacgca
    21601 ccagacatcc gaaaccgtcc tcgttgcatc cttctatttg gtttaactat cgggaacttt
    21661 tcacgcgaca atgcagcaag tttcctgagg aatatcgcac aatctgccct ctccacatca
    21721 cccacgcaaa gctctatcat tgtaagtctc gacagctgca aattgcccac caagatttta
    21781 cgcgcgtaca ctgcggatgg agtagttccc ttcgcacttg cgtcgttaag ttatgccaac
    21841 tccctgtttc accccaaggg cgacagaaaa atttttaacg aggaagattg gtacttccat
    21901 agtgaatgga accatgccct aggacggcac gaagcatctc taatcacgca atccaaggac
    21961 attcagctgg gtgctcctct agagactgtc atcgtgcgca gggatgagaa gatccgtttt
    22021 gggtgcagtt ataaatatga taaagccgaa cgggaccagc tctttcactc cgctggtctg
    22081 gaggatgcag ctgtatggac agccccagac tgtgatgtgg cattttacca gttgagactg
    22141 cgtctgaact ga
//
