LOCUS       BGC0000812             26001 bp    DNA     linear   PLN 20-JAN-2014
DEFINITION  Shiraia sp. slf14 huperzine A biosynthesis gene cluster, complete
            sequence.
ACCESSION   BGC0000812
VERSION     BGC0000812
KEYWORDS    .
SOURCE      Shiraia sp. slf14
  ORGANISM  Shiraia sp. slf14
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Shiraiaceae;
            Shiraia; unclassified Shiraia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 20:41:49
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..26001
                     /db_xref="taxon:665115"
                     /mol_type="genomic DNA"
                     /organism="Shiraia sp. slf14"
     misc_feature    1..26001
                     /note="huperzine A biosynthesis gene cluster"
     subregion       1..26001
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000812"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..26001
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     mRNA            <503..>1357
                     /gene="CBR4"
                     /product="quinone reductase"
     gene            <503..>1357
                     /gene="CBR4"
     CDS             503..1357
                     /EC_number="1.1.1.-"
                     /NRPS_PKS="Domain: PKS_KR (7-208). E-value: 3.1e-09. Score:
                     28.8. Matches aSDomain: nrpspksdomains_CBR4_PKS_KR.1"
                     /codon_start=1
                     /gene="CBR4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     120.1; E-value: 1.9e-36)"
                     /gene_kind="biosynthetic-additional"
                     /note="3-oxoacyl-[acyl-carrier-protein] reductase; carbonyl
                     reductase family member 4"
                     /product="quinone reductase"
                     /protein_id="AHG26146.1"
                     /transl_table=1
                     /translation="MALRPRHVLITGGSRGIGLSIAQLFAKNAYRCTLISRSEDNLKTA
                     VSSLQPLLDTSPASSSPTPSDNTSTSTAPSTSHSYITGNISDPNFWTSNNHSSSISTQL
                     PSPPPKSANHDSKIDVLVNCAGITQSSIFLRTQPSAIEELIQTNLTGLMIGTRFLMRHG
                     YLRGGKEDTHFSPVIINLSSLLGVRGGHGAVAYAASKAGVLGFTRALATEYATHRVRVN
                     AIVPGYIETDMTKDLDAQGLVGRIPLGRFGTPEEVAHAALFLAENQYAHNCVLNLDGGL
                     SAI"
     aSDomain        524..1126
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CBR4_PKS_KR.1"
                     /evalue="3.10E-09"
                     /label="CBR4_PKS_KR.1"
                     /locus_tag="CBR4"
                     /protein_end="208"
                     /protein_start="7"
                     /score="28.8"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VLITGGSRGIGLSIAQLFAKNAYRCTLISRSEDNLKTAVSSLQPL
                     LDTSPASSSPTPSDNTSTSTAPSTSHSYITGNISDPNFWTSNNHSSSISTQLPSPPPKS
                     ANHDSKIDVLVNCAGITQSSIFLRTQPSAIEELIQTNLTGLMIGTRFLMRHGYLRGGKE
                     DTHFSPVIINLSSLLGVRGGHGAVAYAASKAGVLGFTR"
     CDS_motif       527..616
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_CBR4_0001"
                     /evalue="2.10E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="CBR4"
                     /protein_end="38"
                     /protein_start="8"
                     /score="20.4"
                     /tool="antismash"
                     /translation="LITGGSRGIGLSIAQLFAKNAYRCTLISRS"
     mRNA            complement(join(<1623..2377,2427..3075,3137..3373,
                     3428..3598,3655..>3717))
                     /gene="uba2"
                     /product="ubiquitin-activating enzyme E1-like protein"
     gene            complement(<1623..>3717)
                     /gene="uba2"
     CDS             complement(join(1623..2377,2427..3075,3137..3373,
                     3428..3598,3655..3717))
                     /codon_start=1
                     /gene="uba2"
                     /note="Pmt3-activating enzyme subunit 2"
                     /product="ubiquitin-activating enzyme E1-like protein"
                     /protein_id="AHG26147.1"
                     /transl_table=1
                     /translation="MPRDSYARRSLGAPLYGRIKDARVLMVGAGGIGCELLKNLVLTGF
                     GEIHIVDLDTIDLSNLNRQFLFRNEHIKKSKALVAKESAGKFNPNVKIEAYHDNIKDPR
                     FNIAWFKTFEIVFNALDNLDARRHVNRMCLAANVPLIESGTTGFNGQVQVIKKGETECY
                     DCNPKDPPKSFPVCTIRSTPSQPIHCIVWGKSYLFAEIFGTSEDDAPELDHSEDAGNAS
                     EVANLRKEAQALKSIRESMGSNDFPRLVFNKVFKEDIERLRSMEDMWKSKRAPEALDYD
                     TLMQDSQGSGSEIAKRDQIVWSLAENFAVFVDSLQRLSNRLEETRAKSDVGNAAPILSF
                     DKDDVDTLDFVAASANLRSHIFGIETRSKFDIKQMAGNIIPAIATTNAMTAGLCVLQAF
                     KVMRDQLDRAKFAFLTRSTERVIASENLQKPNPRCATCSVAYATLAVDIKRAKLRDLVE
                     GVLKERLSYGEDFSVKRESDLLYDIDEDVHLDKTFEELGLKADVFITVFDEADDNAKVD
                     VVFSVIEQEVADDAKAIEVAGELVIPKKPKPPVEEANGHAMANGRVDATMHPTNGTTTL
                     PAKRKASAIESEDDIVRKKGKVMEGPSTNGVKDDDIVVIEDDGAIVLD"
     mRNA            join(<4123..4921,4974..5096,5148..>5320)
                     /locus_tag="SLF14_114"
                     /product="hypothetical protein"
     gene            <4123..>5320
                     /locus_tag="SLF14_114"
     CDS             join(4123..4921,4974..5096,5148..5320)
                     /codon_start=1
                     /locus_tag="SLF14_114"
                     /product="hypothetical protein"
                     /protein_id="AHG26148.1"
                     /transl_table=1
                     /translation="MSDDEVDHELLDLLRKRFGIGTKDEGPPETKVLENAQFIYNNSVD
                     VAVDMRSTKQAAQAVLAEMEKREYSTKTWSEHELHPKAKDESTANFIFTMDVLNFSFWS
                     DKSDEERFAVVYKGKRWTGYWSLVALLQRALEQGIPITSPGFWIDEEKCTDDVLRAVFM
                     SGTEEEIALFDERVRCLREAGRILEEEFDGSVITLIEDAKNSAAGLVNLLADKFPCFRD
                     EGTFERKKVRFLKRAQIFVADLWAAFEGEGYGEFNDIDKITIFADYRIPQMLHSLGIIW
                     YCPPLENKIRRLEVIESGHSWEMQIRGCSIWGVELLRQEIVKLKPDAKINAILIDFFLY
                     DMAKEKELEEAEIIPHHRTRSIWY"
     mRNA            join(<6267..6507,6562..>7802)
                     /gene="yvdP"
                     /product="FAD-linked oxidoreductase YvdP-like protein"
     gene            <6267..>7802
                     /gene="yvdP"
     CDS             join(6267..6507,6562..7802)
                     /EC_number="1.21.-.-"
                     /codon_start=1
                     /gene="yvdP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 280.8;
                     E-value: 5.1e-85)"
                     /gene_kind="biosynthetic-additional"
                     /note="berberine-like"
                     /product="FAD-linked oxidoreductase YvdP-like protein"
                     /protein_id="AHG26149.1"
                     /transl_table=1
                     /translation="MASMALQTCLLDAVSGSVAFQGQPFYQIANVQPYNLDVPVNPVAI
                     TYPRSAQQIADVVQCAVQSSMKVQARSGGHSYANYGLGAGNDNTVVVDLKNMKQFSMDT
                     NSWQATVGSGTLLGELTERLHNNGQRAIPYGTSPTIGIGGHATIGGLGPTGRQWGLTLD
                     QILEVEVVLANSSIVRASDTQNSDLFWAIRGAAAGFGIVSEFKFRTHPEPGSNVQYSFN
                     FGALDAKSKAQAFLKWQELISDPSLSRKFASTVTVTQDLGMVISGTFFGSREEYDSLNI
                     ESRLPTTNDSMVQIQGWLGTVANWADDLALKLVGHTPSHFYSKSLGYTRNDLLSEEVAE
                     NLFQYLEDADKGSPVWFLVFDLEAGAISDVASDATSYGHRDALFFHQSYIVNLLGDVTQ
                     TSRDFLDGINNLVSTALPNHPQGAYPGYVDPELGAQAQQDYWEGNVPRLEQIKAMVDPT
                     DVFHNPQSIRPSAARKMRRDPSPSGPGASKPSIGN"
     mRNA            <8435..>8647
                     /locus_tag="SLF14_116"
                     /product="hypothetical protein"
     gene            <8435..>8647
                     /locus_tag="SLF14_116"
     CDS             8435..8647
                     /codon_start=1
                     /locus_tag="SLF14_116"
                     /product="hypothetical protein"
                     /protein_id="AHG26150.1"
                     /transl_table=1
                     /translation="MGQRTSKQTSYDPAYAGRPQHHNTAYNGNGGTSYDQSAYEYQARK
                     DARKAQKKRRSRMNGVVAAAAAGAS"
     mRNA            <9162..>9806
                     /locus_tag="SLF14_117"
                     /product="dimeric alpha-beta barrel"
     gene            <9162..>9806
                     /locus_tag="SLF14_117"
     CDS             9162..9806
                     /codon_start=1
                     /locus_tag="SLF14_117"
                     /note="antibiotic biosynthesis monooxygenase"
                     /product="dimeric alpha-beta barrel"
                     /protein_id="AHG26151.1"
                     /transl_table=1
                     /translation="MVVTEIALLRLWSGVVIGNADLKSKLAHAKKVMQDYTGRQFYYYQ
                     QIEDPSCIYIIGEWESLDQHMNHFIPSRDNQSVLESLKDLLAVEWLQHIDVSHIDLPLP
                     KTEDEKATIHRHELVLSIVRHFVKDGEKEKFQETFETNKHHLQDFITLGNMGGGWRVDK
                     EDSKEEWVVFCPWSSVEQHQAFASTEGFAKYGQIRGHIDGAEIKHARFLEI"
     mRNA            join(<10256..10360,10411..11563,11613..>12013)
                     /gene="cyp450"
                     /product="putative cytochrome P450"
     gene            <10256..>12013
                     /gene="cyp450"
     CDS             join(10256..10360,10411..11563,11613..12013)
                     /codon_start=1
                     /gene="cyp450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034:cytochrome P450 (Score: 163.2; E-value: 1.7e-49)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome P450"
                     /protein_id="AHG26152.1"
                     /transl_table=1
                     /translation="MMDHMLSLMHQLENIPLTYGVILLLFTLTIVAAYRLSTRTDIPYI
                     RGIPEIPGALPVIGHLIQLGEDHATVCEKWWRKYGHSVFQIRLGNTRAVVINSFDDCRK
                     ILVSNPQGLIDRPKLFTFHGLISSTQGFTIGSSPWDESCRNKRKAASTTLSKGMMKNYY
                     DMFDLESYCIVRDLQRDSKGGAFEVSIRPYIQRYALNTTLTLCYGIRMDAVYDDLLREI
                     LYVGSAISLLRSASENYQDYVPILRYLPNNEKNRRSKELRERRDKYLSELLDKVREMIK
                     VGTEKPCISAAILKDEETRLTGVEVSSICLSLVSGGFETIPGTLVSCIGSLSTVEGQIY
                     QERAYKEIKKIHPDIKQAWAGDFEKESVPYLNAIVKEAGRYYTVSNMSLPRKTMNDVRW
                     GDAVIPKGTMVLINAQAGNHDVDHWGPDAATFNPERWLDSPDPSDPTALYTEKPTPSTP
                     HLSFGAGSRSCPGAMIAAKLINAALFRILSLYKIEASTTDPPNTDYVDYNAIKSALVAI
                     PRDFKIKLTPRDGSRELARKVLGVGEERTRNFYKE"
     mRNA            join(<12377..12611,12690..12961,13052..13097,13142..>13746)
                     /locus_tag="SLF14_119"
                     /product="hypothetical protein"
     gene            <12377..>13746
                     /locus_tag="SLF14_119"
     CDS             join(12377..12611,12690..12961,13052..13097,13142..13746)
                     /codon_start=1
                     /locus_tag="SLF14_119"
                     /product="hypothetical protein"
                     /protein_id="AHG26153.1"
                     /transl_table=1
                     /translation="MMLRTAIVATAVLAALCASQLLDSPHIAAISFDLKKFANDDLWKL
                     HVEKGAHQLCLMQATDKGAGFLMQDSRNPPSAANKLKEWGWRESADIDTDEADFDKQNL
                     RTTFDALKLNTKPKYDDDGDPVGGDNEFISIAHFDYKDYEDPNAQFPRMKNVLEQKYKV
                     GDKEYSATGAYYDFVVNTKGGAIIGKALESPATAVTQLLNWGRPAQPGELPELRHCSDM
                     YWGHWIRDNPNVKNLRVYGAQNVVNDATSLLVSRAFKNRNVEALTPWPGQSFEATTDEG
                     KAIIGSPIGGTIAHMLIRHKAELGIKHITKVTVVMRDYPKGGFGSKYKPDIHLFFHIED
                     VPEDQIPQDGGLQERMRRTPTLNMSNEVSVSVQGNNIVRLHKARL"
     mRNA            join(<14379..15216,15280..>15614)
                     /locus_tag="SLF14_120"
                     /product="long-chain-fatty-acid--CoA ligase"
     gene            <14379..>15614
                     /locus_tag="SLF14_120"
     CDS             join(14379..15216,15280..15614)
                     /codon_start=1
                     /locus_tag="SLF14_120"
                     /product="long-chain-fatty-acid--CoA ligase"
                     /protein_id="AHG26154.1"
                     /transl_table=1
                     /translation="MLATLFAFAICTVAVWCNDWDPVNWRWLAIAPEEIPHLERYGNDY
                     WCALRGSDRAAGIQMGDTRTPPTAESVFIRRPDGDRPRWNWHEIWAGHMVDAFDSAGWT
                     QVMTDLNKDVRDPNWSFVMFIHGDPKDPRPCHMQTYRTGNPEPNAVWPEATRKSTCAMI
                     QFAFNRNYNIIVLTHWWSPKNAAHTNWPDLGDEQPIHVSHLPQLRHISDLVWEPWIKAR
                     AYGVPRIDFFAWSDIQEPLLFGIMATILIQRGLPEPELWPAMNSVVLMDSSEGRAMLGT
                     STGKAVAFFLIQHKKRWNRPQHIESFTFFRGPTIDGKYKIQLIFKITPVPENMEHKDPN
                     PPGPLPVPYPPALFPIARSVPTDHTNRTKNGMLVESQGPKNFMRVHKVHM"
     mRNA            complement(join(<15915..16555,16859..>16997))
                     /locus_tag="SLF14_121"
                     /product="acyl-CoA N-acyltransferase"
     gene            complement(<15915..>16997)
                     /locus_tag="SLF14_121"
     CDS             complement(join(15915..16555,16859..16997))
                     /codon_start=1
                     /locus_tag="SLF14_121"
                     /note="GNAT family acetyltransferase"
                     /product="acyl-CoA N-acyltransferase"
                     /protein_id="AHG26155.1"
                     /transl_table=1
                     /translation="MAPSYLPFYGVNFRPTGTAESPAHLTLMPYATFNGNIDCISTSIV
                     WAYYGPTHDVLHNGAITDSSIRGVAESRKQELKQPNMWHWIVIDTDLPPGKDDPPSNPG
                     QTIAISAWSLKNAKKDVDAVPALDDATTRSTQKQEEPPFLPPELRLDALNSLFGPLRDV
                     QEEVMGSEEPYLMLRTLATHPDHQRRGAAKLLLDWGLEMADDLGVPIYLDGTSSGKPVY
                     EKNGFKEIKRVEWDREPWGGKGKDCHWCMVRQPRTPQ"
     mRNA            complement(<17061..>18137)
                     /locus_tag="SLF14_122"
                     /product="ferrous iron transporter"
     gene            complement(<17061..>18137)
                     /locus_tag="SLF14_122"
     CDS             complement(17061..18137)
                     /codon_start=1
                     /locus_tag="SLF14_122"
                     /note="Fe2+ transport system protein"
                     /product="ferrous iron transporter"
                     /protein_id="AHG26156.1"
                     /transl_table=1
                     /translation="MESEGHTPKGCASAPRAQAPPASLPPLDEVFGGSLDYHYAFYGYT
                     TRKGHRLNASLSTPPPDWGLRLHAHFLRGPDLALFSTKDLPPHLVPFFAFKDTVVYGSS
                     SGMLAYPFSLFETIYREWYPTRDRSVFKYGLYHSPGAAFFSSTVRVDFDAPIPQPQVQL
                     GLLICYHYALSRRLHEILPSFPYLVEGGKMLVRADLSPDELRAVPKIRAHVPYTPVMRR
                     TLSECFLFIDGKWEEHGVRLVVLSEDMLRRMLSEDGYAMTRDFDIEEEVKKVAEEAMLN
                     GQKGLDEHDDIDVKAQMNHVSIWKGKLVDAMRAVVGGDEARKPGRLDYNWELQEWLGEG
                     VPVGNDGRPLTLSDDTDS"
     mRNA            join(<19569..19695,19745..19807,19861..20142,20193..20780,
                     20871..>22498)
                     /locus_tag="SLF14_123"
                     /product="hypothetical protein"
     gene            <19569..>22498
                     /locus_tag="SLF14_123"
     CDS             join(19569..19695,19745..19807,19861..20142,20193..20780,
                     20871..22498)
                     /codon_start=1
                     /locus_tag="SLF14_123"
                     /product="hypothetical protein"
                     /protein_id="AHG26157.1"
                     /transl_table=1
                     /translation="MWYHFFILMSLLTATAFSQPDNSSSLYLTPSLITETASLPTTRCA
                     SVTATSLGLTGLCEDNHCSCSGIAVPPLPDVITRPSSKGCSHQDQFTSLNCPSRTEPAP
                     IPTLGFNNSHTPFPNTTFIENPLQDDQTATRTFLPKVSSELSTLAFSSTVLSAVSLSTP
                     ILSESASFRPSSSIISISSSTSVSISSSTINPVPPSPVVPIHPVTTFQKPTSSEESLPF
                     ITSFDLAILALTSIDPTISTHTAIYISQGNYPAGLYPFIRGSTKCFFCPPGTEHGGFSL
                     WGMNKPGIYPPPIPPPVPNVRWPTITISPGSKPTLGPFPEPKDPGDLSQSRTSKECTIT
                     TVSSCAVSCATPSGSCYIRNWATINDQIDDSSPGNRGDAGPDTSDIPASVPAKSSQTAS
                     VSSKGSSGTTPTKTSSAGATMVTSTKNVAVTTTAARNFCVPYQNPSRGESYCTCEDQSS
                     RSFLYDKGNCPTTSQPLISTPKPTSESPKTDSSGNIWNSTDIVLGTIWDCKSTSIVRGL
                     APVPITKCLSSSSIGMDFTPTPAPPVSTFQPPQPTGPKKECDTCSSDMGASSCGANDLI
                     CLINECKANKHCKSCGIDCSSFRPGSLSRARDLIYERIFLSGRLKKLSERLSRRKEIQS
                     TTLTRIRSFFKRAEHGASWKKYAPKGKKYYKILQDQPMEDTVKAKMCELDEYFKVTKGD
                     VLVPGLKKPILEKINIVPTKSYFPIHAIGPVEGKSKAGEQKEISDFMLSISPEQGVIFA
                     NAVENGEIKVNGVITQRGIPYQLSTVVWWMWKHIVMQGQSPDTKEEETDFSNVKYFFHY
                     DITNGETSDILKEAIGNGREPVSFTPQDDSDDNAFWPLLGSPNGNSMAWFFIDNKKSLK
                     GKTIEKITAWFDHRKNYQLWATFV"
     mRNA            complement(join(<23763..23794,23841..25471,25574..25664,
                     25693..25732,25790..>25834))
                     /locus_tag="SLF14_124"
                     /product="fungal specific transcription factor domain
                     containing protein"
     gene            complement(<23763..>25834)
                     /locus_tag="SLF14_124"
     CDS             complement(join(23763..23794,23841..25471,25574..25664,
                     25693..25732,25790..25834))
                     /codon_start=1
                     /locus_tag="SLF14_124"
                     /product="fungal specific transcription factor domain
                     containing protein"
                     /protein_id="AHG26158.1"
                     /transl_table=1
                     /translation="MATGLEKRGCAATVRSSVNDVVNTKRQAGLRYLPKEEAKMYMGCW
                     HIKLYNMHQIQRDLNRIAEYESRVKRLESLLQERSAEQPQLEQQPLQPANDPVPAAKWV
                     ANLRNSIDTIVQRDYLDFESLLFKDFTDSSSLAHCNRNSNSQNVPSLPGEIGVSCSNVP
                     KGDSSGPSPTVRKDTSNLPCGNIVNETLLSRHSTDSPHFPITINACEEYLPPPTLGTAL
                     LSEFLVDFNTAYPLYRPHDISNHLRICYAGHAAQDHPVSWTSAYVVFGLAHTLRAMSIT
                     ATPADMELAKYYVSRIYSNLNHLLLSHPSLGLVQCLIGAAKLIRSTQCGCNLADGPLLS
                     TSLRVAQSLAYHEEEPELPDSTRDIEQERRVFWLSFICDTYTAIASNTPTTHRRDDIIA
                     PKPALNPADNVGEIVAAEGFWKVNFFLLRVELALLQAEAVEQVLSAKAQNKAIDIEAAA
                     AAVLARLKGFHNHKLFSLGPEQMSHLLYRSDIAHTVSLESGYFMTVHRLQAFLAFDKNH
                     RVNPFSLMGMTRLSQMTEQKSYHEARRLLSLLPIAPRGDVALYWNEYKAFQVALITVLA
                     HHAHAPESAVLQESDLDMFRALIEGLEIFALASLQE"
ORIGIN
        1 tattgtggga agctctacac gattctgggt attctctctg aaaccagcta tgacaagtgg
       61 tcagctgaat ccagcggtgc ctcaaacatc cgagaagcac gtacacaatg gatccaaagc
      121 cttcttgata gtgcctgcta tacacgccgc agagcgtaag actttgaact cgtacccgtc
      181 gttcgagaca agggtgacat attgcgataa cgaattttca gccattattg gtacaagtcc
      241 agtgtttcag ccgggtatgt tggggtcgga atgttgacgt gtgagatgtg acgtgggtgt
      301 gctgcgggga acgatgcgtc ttcgcgcggt cacgttttct cgcgcgtcgg tgtctcgaga
      361 tgactaagca aactatatcg aatctccatc acagaactct agtcatattc cacaaataag
      421 atttgatcaa ttattgccct ggaacccgag tcacaccttt aaagtaatcg atctcttgat
      481 attcgtgaaa acaaggaagg ctatggcact acgaccacgg catgtcctca ttacaggcgg
      541 ttctcgaggc ataggccttt ccatcgccca actcttcgcc aaaaatgcat accgctgtac
      601 tttaatatcc cgttcggaag ataatctgaa aaccgcagta tcatcattgc aacctctact
      661 agacacttca ccagcatcct catccccaac cccatccgac aacacatcaa cctcaacagc
      721 tccatccact tcccacagct acatcacagg aaacatctca gacccaaact tctggacctc
      781 aaacaaccac tcctcatcaa tcagcacaca actccccagc cccccaccaa aatccgcaaa
      841 ccacgactca aaaatcgacg tccttgtaaa ctgcgctgga atcactcaat caagcatctt
      901 cctgcgcacc cagccttccg caatcgaaga gctcatccag acgaatctaa cagggctgat
      961 gatcggtacg cgcttcctaa tgcgccatgg gtatttgcgt ggcgggaaag aagacacgca
     1021 cttcagtcct gtgattatca atttatcttc gctgttgggc gtgaggggtg ggcatggcgc
     1081 tgtggcgtat gctgcttcga aagcaggagt attgggcttc acgcgcgcac tagctacgga
     1141 gtatgcaacg catagggtgc gtgtgaatgc gattgtgcct gggtatattg agacggatat
     1201 gacgaaagat ttggatgcgc aaggactggt ggggaggatt ccgctgggga ggtttggcac
     1261 gcctgaagaa gttgcacatg cagcattgtt tttggctgag aatcagtatg cgcataattg
     1321 cgtgttgaat ttggatgggg gtttatctgc tatatgagca gttaagctac tcgtctgcct
     1381 tttgtggctg aatgccgtcc gttttgagcc gaaatggcgg ctcgtctacc attccttcgt
     1441 gatggtgcct gtaaatcgca aaggtatatc catccttccc aacgccgttc ccattttcag
     1501 atgctgataa tgtacaagag agaaatctat atgctgcaca gatacaggcg cggcacattt
     1561 tgacgtgcct tgactgagct acggagtctg tcagcgaaag cgacgaattc acatcgcagg
     1621 atctagtcga ggacgatagc gccgtcatct tcaatgacca cgatatcatc gtccttgaca
     1681 ccattggtgc tcggcccttc cataactttg cccttctttc taacaatatc gtcttccgac
     1741 tctattgcag aagccttgcg cttcgctgga agggtggtcg tcccatttgt cggatgcatt
     1801 gtggcatcga ctcttccatt tgccattgcg tggccgtttg cttcttcgac gggaggtttg
     1861 ggctttttgg gaatgaccaa ttccccagca acctcgattg ctttggcatc atctgccact
     1921 tcttgttcga taaccgagaa cacaacgtct actttggcat tgtcatctgc ttcatcgaag
     1981 acagtgatga acacatccgc cttgagacca agttcctcaa aggtcttatc tagatgaaca
     2041 tcctcatcga tgtcatacag aaggtcggat tcacgcttca cgctgaaatc ttctccatag
     2101 cttaggcgct ccttcaggac accctccacg agatcgcgta gctttgcgcg tttaatgtca
     2161 accgcaagag tagcatacgc tacgctacaa gtagcgcaac gaggatttgg cttttgtaga
     2221 ttctcactcg cgatcacacg ttcagtactc cgggtaagga acgcaaactt ggccctgtca
     2281 agctggtcac gcatcacctt gaatgcctgg agaacgcaga gacctgcagt catggcattg
     2341 gtagttgcaa tggcagggat gatgttaccg gccatttcta tagtagttta gcaggatgtt
     2401 tgatgggccg caaataggat actcacgttt gatgtcgaat tttgaccttg tctcgatgcc
     2461 aaagatatgt gaccgaaggt tcgcgctcgc tgcgacaaag tcgagggtat ccacgtcgtc
     2521 tttgtcgaaa cttagtatgg gtgctgcgtt gcccacatct gattttgcac gtgtctcttc
     2581 caagcggtta ctgaggcgtt gcagactatc tacaaagacg gcgaaatttt ctgctagact
     2641 ccacacaatt tgatcccgtt tcgcgatttc tgagccggaa ccttgtgagt cctgcatcaa
     2701 ggtgtcatag tccagggctt ctggtgcccg tttagatttc cacatgtctt ccatgcttcg
     2761 taaccgttcg atatcctctt tgaaaacctt gttgaaaacc aaacgaggaa agtcatttga
     2821 tcccattgat tctcgtatgc tcttaagcgc ttgtgcttct ttgcgcagat ttgcgacttc
     2881 gctggcatta ccggcatctt cactgtggtc gagctccggc gcatcgtcct ctgaagtacc
     2941 aaagatctct gcaaataaat atgatttccc ccatacaatg caatgaattg gttgcgatgg
     3001 ggtgcttcgg atcgtgcaga cagggaacga cttgggtggg tcttttggat tgcaatcgta
     3061 gcattcagtt tcgccctaat ttggttgttg gcccgactcg ataaattatc ggtgtcgcga
     3121 aatggatggt gcttactttt ttgatgacct ggacttgccc gttgaagccg gtggtaccac
     3181 tttcaatgag cgggacgttg gcagccagac acatccggtt gacgtgtcgt cgcgcatcga
     3241 ggttgtctag cgcattgaag acaatttcaa aagtcttgaa ccacgcaata ttgaatctcg
     3301 gatctttgat gttgtcgtgg tacgcctcaa tcttgacgtt ggggttgaac ttgcccgccg
     3361 actccttcgc cacctaacca gaagtcagcg catgccaatg tacttttacc gatcatcgcc
     3421 gacctaccag agcttttgac tttttgatat gctcatttcg gaacaagaac tgccggttga
     3481 ggttgctgag gtcgatggta tcgaggtcga caatatgaat ttcgccaaat ccagtgagga
     3541 cgaggttctt gaggagctcg caaccgatgc caccagctcc taccatcaaa acacgtgcct
     3601 aatgtctcgt cagcgacctt ggtatcgcgt gtttgcgtct cattggagct gtacatcttt
     3661 gattcggccg taaagcggag cgccgaggct gcggcgagca tagctgtcgc gtggcattgc
     3721 tggttgattg tcgagatagg cgaagcgcga ctcgattgtc ctacgcgcga gaaaccgtca
     3781 tgcgaggatt gggcgagcgg ttgtcgtgga gatcgaaggt gacaggtgag agaacgtcag
     3841 accagttcca tgcgcctaag atggtccgtg caccgacggc aaggctgttc agccgcaaag
     3901 catggggtca agttagccga gactgtttga gtggatcgtg aatttttgtg gagtcagata
     3961 tggaaatgtt tctcgactgt ccctgcgtca cgcttccgcc attcacatta ctttttctga
     4021 gccgactgct tgcctttacc taagtaaaac tgcagtgatc cttggcgact catatcttgt
     4081 tcatccgtcg aggttttttg agggcacgtc tttgtactca ccatgtctga cgacgaagtt
     4141 gatcatgagt tgcttgatct tctacgaaaa cgttttggta ttggtaccaa ggatgaaggg
     4201 ccgcctgaga ccaaagtgct cgaaaatgca caattcattt acaacaacag cgttgatgtt
     4261 gcggtggaca tgaggtcaac taaacaggct gcgcaggcag ttcttgcaga gatggaaaaa
     4321 cgcgaatata gtaccaaaac atggtcagaa catgagctcc atccgaaagc caaggatgaa
     4381 agcacagcca atttcatttt caccatggat gtcctcaact ttagcttttg gagtgacaag
     4441 agcgacgaag agcggttcgc tgtggtctac aaaggcaaac gttggacagg gtactggagc
     4501 ttagtagcat tgctgcaaag agctctcgaa cagggcatcc ctattaccag ccctgggttc
     4561 tggatagacg aagagaaatg caccgatgat gtcttgcgag cagttttcat gtcgggcact
     4621 gaagaagaaa tagcgctatt cgatgagcga gtacgatgtc taagagaagc tggccgcatc
     4681 ttggaagagg agtttgatgg cagtgtcatc acacttatcg aagatgcgaa aaattctgca
     4741 gctggactgg tgaatttact tgcagataag ttcccttgct tccgagatga aggcacattc
     4801 gaaaggaaga aagttcgatt tctcaaacga gcccaaatct ttgtcgcaga tttgtgggca
     4861 gctttcgagg gtgagggata tggagagttc aatgacatcg acaaaatcac gatctttgca
     4921 ggtacatttc tgctatactt tcacgtcatc aaaattcgct aatcaaactc cagactaccg
     4981 tattccgcag atgcttcact ccctgggtat catttggtac tgtccacccc ttgaaaacaa
     5041 aattagacgc ctcgaggtaa ttgagtcagg gcactcgtgg gagatgcaaa tacgaggtat
     5101 taaattccca aagactgcag tgtgttacgt cactgaccat tacataggtt gcagtatctg
     5161 gggcgttgag ttgctccggc aagagatcgt caaattgaaa ccggacgcaa agatcaatgc
     5221 cattctcatt gactttttcc tgtacgacat ggcaaaggag aaggaactgg aagaagctga
     5281 aatcattcca catcatcgga cgaggagcat ttggtactga gatttgcaaa ggattactgg
     5341 tgggccttgg cgttggtaat agaatgggca ttcggatgta tgacaatacc ctagacggac
     5401 atctggaagc aaactttcca aaagagttca acattgatga cactgtaggg cttcttctcg
     5461 tggcggtgat acgtgttcag tggcttgcac gtcgatcttg atcgtgcttc tgtcttggca
     5521 acccaagatc atggtaacag aacgcaggaa ctttccatta gccattttca gtccactctg
     5581 cttttcgagg agaaagttcc gtggctcgtt ctccattctg atttgcgcaa ggatccatta
     5641 cgctatgtca atgttggtta ggcgtatgca tcaaggacga tctccagtac ggcccgaact
     5701 ctatcactca tttattatga aatgttgacc attcacatca gcaatgggtt ttaaggtatt
     5761 aagactgagt atcatggata ttttcggatc gcacaaacca tatcgaaggg ttcttcagtc
     5821 aagttcattt gttctaagag gagaatacgt gaaggtatgc ttgagcacgg tccgtgcatg
     5881 gcaggattat gaaaatgctg cggaaagcag cggaaactaa gcttgtatgc ccggactatc
     5941 tcgttcagcg ctggtaaatt tgacctaata aagccgaacg gcgattggtt tgattcgaca
     6001 atgtgtacca acaaccctct tcatcgcatt cgcgttctct ggcatctccc ggcacctgtt
     6061 catgggtaac tttgactcca ctcggcggag ccatcggtgc tacctcagtc gttgcccaac
     6121 attcgactat ccaaataaaa gatgactata tagatgtcaa tggctgccac catgaccata
     6181 ctctcatctc acttcaactc tcattcattc tcttctatct acacttgcta gttgctactt
     6241 gaacgatcaa cctcacgaca atcataatgg cgagtatggc gttgcagaca tgtttgctgg
     6301 atgccgtaag cggatccgta gcattccagg gccaaccatt ttatcagatt gcaaatgttc
     6361 agccatacaa cttggacgtt ccagtcaacc cggttgccat tacataccca agaagtgcac
     6421 agcagattgc tgatgttgtg caatgtgctg ttcagagcag catgaaggtg caagccagga
     6481 gcggtggaca ctcttatgcc aattacggta cgtcaatcaa acgtggatgt cgtcaatatg
     6541 acttctaata atcgcttcca ggactcggag ctggcaacga caacactgtt gtggtcgatc
     6601 tcaagaacat gaaacaattc tccatggata ccaattcctg gcaagctact gttggaagtg
     6661 gcactcttct tggagagtta acggaacgcc ttcacaataa cggccagcgt gctatacctt
     6721 atggtacttc tccaaccatt ggaattggtg gccacgccac aatcggtggt cttggcccta
     6781 ctggccgtca gtggggcttg acactggatc aaatcctaga agtcgaggtc gtactggcca
     6841 attcttccat tgtacgcgct tctgataccc aaaactccga cttgttctgg gccatcaggg
     6901 gtgccgcagc tggttttggt attgtcagcg agttcaagtt ccgcacccac cctgagcctg
     6961 gcagcaatgt gcagtactcg ttcaacttcg gtgctctcga tgccaagtca aaggcacagg
     7021 ctttcctcaa gtggcaagag ctcatttctg acccgtctct atctcgcaag ttcgcttcaa
     7081 ctgttactgt cacccaggac ttgggcatgg tcatctctgg aacctttttc ggcagccgtg
     7141 aagagtacga cagcttgaac atcgaatcgc gtcttccaac caccaacgac tccatggtcc
     7201 aaatccaggg ttggctcggc actgttgcta actgggcaga cgacctcgct ctcaaactcg
     7261 tcggacatac cccttcgcac ttttactcca agtcgctcgg ctacaccagg aacgaccttc
     7321 tctcagagga agtagctgag aacctcttcc aatacctcga agatgcggat aaaggtagcc
     7381 cggtctggtt cctcgtcttc gatcttgaag ctggcgccat ctcagatgta gcttcagatg
     7441 ccacttccta cggacatcgt gatgccctgt tcttccacca gtcttacatc gtcaacctct
     7501 tgggcgatgt cactcaaacc agccgcgact tcttggatgg catcaacaac cttgtttcaa
     7561 ccgcgcttcc taaccaccct caaggcgctt acccaggtta cgttgaccct gaacttggtg
     7621 ctcaggcaca gcaagactac tgggagggca acgtgccacg cttggagcag atcaaggcca
     7681 tggttgatcc aactgatgtc ttccacaacc cccaaagcat tcgcccttct gcggcccgca
     7741 agatgcgacg cgacccctcg cccagcgggc ccggcgcctc aaagccatcg atcggcaatt
     7801 agcttgcgca gaagcaaatg ttgaaagtag agaatctttt atttcttgta gccaggtaca
     7861 tcgattgtaa atgctgtaaa ctttcatgta tagcgggcct tttttataac ttctgctggc
     7921 aaattgaagc tgggtttatt tactcgtaga cgagattgag caatcaacat tttatcccaa
     7981 atcgccttgc gatatgtacc actgatcgtg atgtttctac atgttctcct ttgctatccg
     8041 aattcacctt ctccatcctt acgacgtcga catacacgct aattgaggca ctgctgagct
     8101 tactgacgac cctaacttac gcccaacggc actgcgccac cccgacccaa ccactcacat
     8161 caacccccaa acttagcgcc acgctgtacg gtcggacata atcctgtacg ccttacaatc
     8221 ctccgtatgc ttgcgactac aatgatgctt acaatgtggc tgcgaccaca tcttgactgc
     8281 atataagctt tcgaccatct ccttggtaag tcttgtattc acatcacatc acaacaccat
     8341 ttcaacctcg tctacacatt tcaacccatc atttcttttc ccgctgcaat caaccaagaa
     8401 ccaaatcaac ctctctgcac agctattcct agaaatgggt caacgcacca gcaaacaaac
     8461 ctcctacgac cctgcgtatg caggtcgccc acagcatcac aacaccgctt ataatggcaa
     8521 tggaggaact tcgtacgatc aatccgcata tgaatatcag gcgaggaaag atgcgcgcaa
     8581 ggcgcagaag aagaggagga gtaggatgaa tggcgttgtg gcggctgcgg ctgcgggtgc
     8641 ttcgtagtgg gctgtggggt acctagtgtt tgtgtacttg ttcaaatgtt ttgtattttt
     8701 agccggggga tacttgttat ttgacgtcta gctactgtgt cgtagtatgc ggattctttt
     8761 ggaattaaat cattgcttta aggatgagca tccgtcccat gtgtgcgtgg aagatgatcg
     8821 cgaggtacat ggcttgatga tgcgcgggca cgtgggtcac cgtttcgccg attcgggttc
     8881 tgcgctggcc gatgcggccg taaggcgtgt atcgagatcg atatcaaggc taatatctcg
     8941 gaaagtatgg ctgtcgagat gctctagtcg aatatggtca ttgttagtag caattagtat
     9001 gttcgtgatc aaggtttgta acatcttagt cgagctaact taacgcgatt tctttgctgc
     9061 ctagcatgcg cattgctttg attcatcagt tgccattacc atcatttctt gagggagtgt
     9121 attcagtttt ttaaagctac agtttttatg aaattcttaa aatggtcgtt actgagatcg
     9181 cacttctacg gttatggtct ggtgtcgtta tcggcaatgc agacctcaag tcgaagctcg
     9241 cacacgcaaa gaaggtcatg caagactaca ccggtcggca attctactat tatcagcaaa
     9301 tcgaggaccc atcatgtatt tatataattg gcgaatggga atcgcttgac cagcatatga
     9361 accacttcat accgagtcgc gacaatcaat cagtcctcga gagcttaaag gacctgttgg
     9421 ccgttgagtg gttacagcat atcgacgtat cgcacatcga tttacccctc cccaagacgg
     9481 aagacgaaaa ggcgacgatc cataggcatg aattggtatt gagcattgtg cgtcacttcg
     9541 tgaaggatgg cgagaaagag aaatttcaag agacatttga gacgaacaaa caccatctac
     9601 aagatttcat cacgttgggg aacatgggcg gaggatggcg cgttgacaag gaagatagca
     9661 aggaagagtg ggtagtcttt tgtccctgga gcagtgttga gcaacatcag gctttcgcgt
     9721 cgaccgaagg atttgcgaag tatggccaga ttcgaggtca cattgatggc gcagaaatca
     9781 agcatgctag gtttttggaa atttaatact agggaatttc ttgagtgatt ttcatgtgtt
     9841 tgatccattt catttagtac ataggtactt aggcaaaact tacacttcaa aatgattgtg
     9901 attcttcgaa gtcagttggt acgcatgtaa gcaggcatcg catcacaagc ttgctactgc
     9961 ttccacaagt accgccactt ttgcattgat gactgggttc atatgtaaag agtgggatgt
    10021 ggtgacaatg ataagggaca attccgttat cttcggaaag gatccgagtt gacccctcga
    10081 cccctcaatg gtattcccag atctgcgcga tggcattatc tcacgcagca catgcgacca
    10141 atcgccgcta gattacctgt catcaatatg tatatccata agtctacaaa cagtcggtgc
    10201 ctggttctgg tgttatgcta catctcgggc tttgtccttg atcttgtact tcatcatgat
    10261 ggatcacatg cttagtctta tgcaccaact tgaaaacatt cccttgacct atggtgtgat
    10321 cttgctttta ttcactctaa ccatagttgc tgcttacagg gtaagttcac gttcgatcac
    10381 attcttatag atcttgacca ctcgtcttag ctttcgacac gtacggacat accatatatt
    10441 cgaggtatac cagagatacc tggagcattg cctgtgattg gacatcttat tcaacttgga
    10501 gaagaccatg cgaccgtatg tgagaagtgg tggcggaaat atggccattc cgtctttcag
    10561 atccgacttg ggaatacgcg tgcagttgtc atcaactcat ttgatgattg caggaagata
    10621 ctagtatcta atccgcaggg cctgatcgac cgacccaagt tgtttacgtt ccatggcctt
    10681 atctcttcca ctcaaggatt cacaatcgga agttcgcctt gggacgagag ttgccgcaat
    10741 aaacgtaaag cagcttcaac tacattgagc aaaggcatga tgaagaacta ctatgacatg
    10801 ttcgatctcg aatcatactg cattgtgcga gatcttcaac gagacagtaa aggcggtgcc
    10861 tttgaagtca gcatacgacc atatatccag cgttacgccc tcaatactac ccttacgttg
    10921 tgttatggca tacgaatgga cgctgtatat gatgacttac tgcgagagat tttatatgtt
    10981 ggatctgcca tctctttgct acgttctgca tctgagaact atcaagatta cgtccctata
    11041 ttgcgctacc taccgaataa tgagaagaac cgccggtcaa aagagcttcg tgaaaggcgg
    11101 gacaaatatc tcagtgagct tctcgacaag gttcgcgaga tgatcaaagt aggtaccgaa
    11161 aaaccttgca tcagtgctgc catcctcaag gatgaagaaa cgcgtctcac tggtgttgaa
    11221 gtaagctcta tttgcctatc gttggtgtca ggcggctttg agacaattcc agggactcta
    11281 gtatcctgca tcggctcctt atccactgtc gagggacaga tatatcaaga acgtgcatat
    11341 aaagaaatca agaaaattca cccggatatc aagcaggcct gggcaggtga tttcgagaaa
    11401 gagagtgtgc cttatctgaa tgccattgtc aaagaagcag ggagatatta cactgtcagc
    11461 aacatgagct taccacgcaa gactatgaat gacgtgaggt ggggcgatgc agtcattccc
    11521 aaaggcacta tggtcctgat caacgcacaa gctggtaatc atggtaagta atgcgcttag
    11581 atataataag tcgcctgtgt tgattgtaac agatgtcgac cactggggcc cagacgccgc
    11641 tacttttaat cctgaacgct ggcttgactc tcctgatcca tcagatccga ccgctcttta
    11701 caccgagaag ccaactccga gcacaccgca tctttcgttt ggcgctggct cacgatcatg
    11761 cccaggcgca atgatagcag cgaaactgat caatgcggcg ctgtttcgta tcttgtcgct
    11821 ttacaagatc gaagcgagta cgacagatcc gcctaatact gactatgtag attataatgc
    11881 gataaaaagc gcgcttgttg cgatacctag ggacttcaag atcaaattga ctccgaggga
    11941 tggatcgcgg gaattggcga gaaaagtgtt aggggtgggc gaggagagga cgaggaactt
    12001 ttataaagaa tgatttggcg tttcctttgc catttcgttc gaaaaggtta tggacgcttt
    12061 gaaatttgta ataaagtatg gggtgatgct gcattattac tcataatagg taaattaact
    12121 tgcgcccatg agctatcttt cactcaggac atcaatagca tttgattggc taatactaag
    12181 cgagattgat tgaagcaacc gcatttgcaa taactcacat atgtttcact aagtggctag
    12241 ctcttatttt tttttgcata tgcactcatc gcgattgcca cagatcccgc ccatatcctt
    12301 agcgcctcct gtcaactcac cacttactca atcacagctc ggtttcagtt cactccagtc
    12361 tccgccgtct cctacaatga tgcttcggac agccatcgtc gccacagccg tgctggctgc
    12421 gctgtgcgca tcccagctgc ttgattcacc tcatattgca gctatctcct tcgacctcaa
    12481 gaagtttgcc aatgatgacc tatggaagct gcatgtggag aaaggagcgc accagctctg
    12541 tctcatgcaa gctacagata agggcgcggg atttcttatg caagattcaa gaaaccctcc
    12601 atcggccgcc agtccatgga gcactgactt aaggagtggg ataaatcact tgcctgtcgt
    12661 ttgagtcaat cctctaatgt aaaatgcaga taaactcaaa gaatggggct ggcgtgaaag
    12721 tgccgacatt gacacagacg aagccgactt tgacaagcag aacctgagaa ctacattcga
    12781 cgccctgaag ctaaatacaa aaccgaagta tgatgacgat ggggatcctg ttggcggtga
    12841 taacgaattc atctccattg cacattttga ttacaaggat tacgaagacc cgaatgccca
    12901 gttccctcgc atgaagaatg ttttggaaca gaagtataaa gtgggagaca aggaatattc
    12961 agtgagtttg ccaacatgtt gactctccat acctttcaaa gggcgataat cataagcgga
    13021 accacaaata ccagtattga ctgagactta ggcgactggt gcttattatg acttcgtagt
    13081 gaatacgaag ggtggaggta cgtatattct gataactcaa gacaaacgcc aactataata
    13141 gcaatcattg gcaaggccct ggaatcccct gcgactgctg ttacacaact tctgaattgg
    13201 ggccgaccag cacagcctgg cgagcttcct gaattacgtc attgttccga catgtattgg
    13261 ggtcattgga tccgagacaa tccgaatgtc aagaacttac gcgtctatgg cgctcaaaat
    13321 gtggtgaatg acgcaactag tcttcttgta tcgcgagcgt tcaaaaatcg caacgtcgaa
    13381 gctctgactc catggcctgg tcagtcattc gaagcaacca ccgatgaagg caaagcaatc
    13441 ataggatctc caatcggcgg tacaatagcc catatgctca tacgacataa agccgagctt
    13501 ggtataaagc acatcacgaa ggtcactgtt gttatgaggg attaccccaa aggaggtttc
    13561 ggttcaaaat ataagcctga tatccatctt ttctttcaca tcgaggacgt tccagaagac
    13621 caaattccgc aagatggtgg actacaagaa cgaatgagac gtactccaac actcaatatg
    13681 agcaatgaag ttagtgtgag tgttcaggga aataatattg tacggctgca taaggcgcgg
    13741 ttgtgatgag cttctcaaag ctaagggtgt ggctagagat cacatataat ggtcttctga
    13801 attaatggat ggttcatgtt ctgtcaatca agcaagtgaa tactacgttt catcgtgcag
    13861 agcaccgtag acccgccttt acttactcga cgtaccacga attcaggcgg agctgtattg
    13921 caagatttga gcgacatcat tggaagtggc caattatatt ctattgcagg aagtaaagaa
    13981 tggcgaaata agcgatggtg ttgctttcta acttcttata gcgtcaatgc agattatctg
    14041 tcattattgg cctgtcaaag ctttgcacaa ttacctttca tcattcacaa ttgcatacta
    14101 cggatgccta cccattcact catttctgcc tctgtataga tataggcggg cactcatgct
    14161 ctcatagtca gttgtcgatc gaaactcttt cttaatcaca caaatacccg cctaagaagc
    14221 ttgcatagag aaatttgtgt gttacaattt ctggatctct ctcaccggtg taatgagaga
    14281 ggctccgagc acagggtccg tgccactgcc ttatagactt tctgctgcta ctcatttcga
    14341 ctctaggagc tccatacctt tgagaccact cggaaaagat gctcgccacc ctgttcgcct
    14401 tcgccatctg cacggtcgca gtatggtgca acgactggga cccagtaaac tggagatggt
    14461 tggccattgc tcctgaagag ataccacact tggaaagata tggcaacgac tactggtgtg
    14521 cccttcgagg ctctgatcgg gctgctggaa ttcaaatggg tgacacgaga accccaccta
    14581 ctgcagaaag cgtctttata cgcagacctg atggagaccg accccgttgg aattggcatg
    14641 agatttgggc cggccatatg gtcgatgctt ttgacagcgc tggatggacc caagtaatga
    14701 cagacttgaa caaggatgtg agggatccca actggagctt cgtaatgttc atacatggtg
    14761 atccaaagga tcccagacca tgccacatgc aaacttaccg gactggcaac cctgaaccga
    14821 atgcagtgtg gccagaagcg acccgcaaat caacctgcgc catgatccag tttgcattta
    14881 atcgcaacta caatatcata gttttgacac actggtggtc gcccaagaac gcagcccaca
    14941 cgaactggcc tgacttaggc gatgaacagc ctattcacgt gtcacacctg ccccaacttc
    15001 ggcatatttc agatttggta tgggagccct ggataaaagc gcgagcatac ggagtaccga
    15061 gaattgactt tttcgcttgg tctgacattc aagaaccctt gctattcggc attatggcca
    15121 ctatacttat ccagcggggg ctcccagaac cagagctttg gccagccatg aacagtgttg
    15181 tgctcatgga ctctagtgaa ggacgagcaa tgctaggtaa attcatccaa gcgcaagata
    15241 tctgagactt ggcggttatg gatgctgact ttcatctagg aacaagtact ggaaaggctg
    15301 tggcattctt tctcatacag cacaaaaaac gctggaaccg ccctcaacat atcgagagct
    15361 ttacgttttt cagaggcccc actatcgatg gtaaatacaa gatccaactg attttcaaaa
    15421 tcactcctgt tcccgaaaat atggaacata aggaccccaa ccccccaggg cctttaccag
    15481 ttccttaccc tccagcatta ttccctatag caagatcagt tccaactgac catacaaacc
    15541 gcaccaagaa tggcatgttg gtcgagtcgc aagggccaaa gaacttcatg cgggtacaca
    15601 aagtccacat gtaaaggtgg tgctagcggc tggtcatcag acaatgtcaa ccctggaaga
    15661 tttgtcaatg gctcagccat attagcctgg agcttttgtt tcagatgaag acaggaattt
    15721 aggacggcac tccagatgtt gaaccacatc ctggaattga atggcggaat tcaactttgt
    15781 agaggatgct tgcagtgaca ttgggatatc atatcaggat gttttgcaag ttcgtgtatg
    15841 cctccgagaa gattatacaa cctttccaga tcggaagtgt ggattacata ggcttctttt
    15901 acaggaacat caatttattg aggtgtcctt ggttgtctca ccatacacca atggcaatct
    15961 ttcccttttc caccccatgg ttctctatcc cattccactc tcttaatctc tttgaaccca
    16021 ttcttctcgt aaacaggctt cccactactt gttccgtcaa gataaatcgg cactcctaaa
    16081 tcatccgcca tctcaagccc ccaatccagt agtagtttcg ccgctccccg cctttggtga
    16141 tccggatgcg tagccagggt tctaagcata agatacggct cctcagaccc cattacttct
    16201 tcttgtacat cacgcaatgg accgaacaga gaattcaaag catcgaggcg aagttcaggt
    16261 gggaggaaag gtggctcttc ttgtttttgg gtagatcgtg tggttgcgtc atcaagtgca
    16321 ggcactgcat ctacatcctt cttcgcgttt ttcaaactcc aggctgatat tgcgatagtt
    16381 tgcccaggat tgctaggtgg atcgtctttg ccgggcggta agtctgtgtc gatgactatc
    16441 cagtgccaca tgtttggctg tttaagttct tgctttcgac tttcggcgac gccgcgtatg
    16501 gaagaatctg ttattgcacc attgtgtagg acgtcgtgtg tagggccgta ataagctatt
    16561 gagcgtatgc gcagccagga gagcatgtca tctggagtca cggggtgtaa ttcgagaggc
    16621 atacttgttc agtgaaggta ggcgtgtcct atcgcgatgt gtgaaaaaga gcccatattg
    16681 aatctacatc atatacatgt gatatgtagc tgcctatact cagatttgca gttgagatga
    16741 gtcaatctga agtaacatga tgagggcgtc agaacgccac ttagcgtggt cgacgttgtg
    16801 ttaagctgcg gaccttcccc attaagcata agcgatgata cctggctcgt acacataccc
    16861 catacaatgc tagtgctgat gcaatcaatg tttccgttga atgtggcgta aggcatgagc
    16921 gttaaatgtg cggggctttc tgctgtgcct gtcgggcgaa agttcacgcc gtagaatggc
    16981 agatatgagg gggccattgt tttcttcctg tcggctagcc attcaatgta tattttgtaa
    17041 gacgcaaagt ctatcttgta ctaagaatca gtgtcatccg acaatgtcaa aggtctccca
    17101 tcattcccaa caggcacacc ttcgcccaac cactcctgca actcccaatt gtaatctagt
    17161 cgccctggct ttctcgcttc atctccccca accacagccc tcattgcatc tactaatttg
    17221 cctttccaga tgctgacatg attcatttgt gccttcacat caatgtcatc atgttcgtcc
    17281 aaaccttttt gcccgtttaa cattgcctct tctgcaactt tcttcacttc ctcttctatg
    17341 tcgaagtccc gcgtcatcgc ataaccgtct tcagacaaca ttctgcgtag catgtcctcg
    17401 cttagcacta ctagtctcac gccatgttct tcccatttgc cgtcaataaa aagaaagcac
    17461 tcagaaagag tacgacgcat tacgggtgtg tatggaacat gtgctcggat tttgggcact
    17521 gcccggagct cgtctggaga gagatctgcg cgtaccagca tcttccctcc ctctacgaga
    17581 taagggaacg aagggaggat ctcatggaga cgacgcgaga gcgcgtaatg gtagcatatg
    17641 aggaggccta attgaacttg tggctgtggg ataggtgcat caaagtccac gcgcaccgtt
    17701 gagctaaaaa aggctgcacc gggactgtga tacagcccgt acttgaatac agacctgtcg
    17761 cgcgtaggat accactcccg atatatagtt tcgaataggc tgaaaggata tgctaacatt
    17821 ccacttgatg acccgtaaac aacggtgtct ttgaatgcaa agaaaggcac taaatgtggt
    17881 ggcaggtctt tcgtggagaa taaagccagg tcaggcccac gaaggaagtg ggcgtgaagc
    17941 ctcaagcccc agtcgggcgg aggtgttgac agagatgcgt taagtcgatg ccctttccgc
    18001 gttgtgtatc cgtagaaggc ataatggtag tccaaactac ctccaaagac ttcgtcgaga
    18061 ggtggaaggg aggcaggcgg agcctgggct cttggagccg atgcgcatcc ttttggagtg
    18121 tgtccttcag attccatgat tcctttgact attgagtgtg gtattttaaa agtgatgttg
    18181 tagttgagac ggcttataac tttagttggg tggcgtagtc aacttatatt ggtacaaatt
    18241 cggaaaatca tgtggtaagg atgtagcgag ttgcgcgtca caaaccctga ttagttgcga
    18301 tgtctgtacc tgaaacctgg acttgtaaat atggttggca tgttcaatcc tagattacaa
    18361 ggcgtgaagc cacgtctgac gtgagttctg tttagtacgg cagcgatcgc catagtttgt
    18421 ggcacagtgg ggatgagccc tgcggggtgc tgtgaagtta cgcgccaaca aacttggggc
    18481 catcaatgtc ttgcaatatg gctgaatgat gtgcgggggc ctatagcatg cccttaccat
    18541 acaacacggt gatagataca tcacggcaac tttcttgatg atatttaaag ccgacgtact
    18601 gccggtgttg agagaaagca gtcatatatt cgaggtacaa ttgatgatga ggcaaacccg
    18661 atgtttggac ctgcgtgatg tcggggtttc ctctgctgta ccacgctact taggtacgat
    18721 acattacatc acttatgatc aagatcagct ctctagccat caatctactc ttaaacttta
    18781 tttagaaccc ttttagaagt tctgccttct ctctcttagt actgtgtcaa tagtgtattg
    18841 ctctcaacgc aatgtctcaa actctcgatc acatgcagtc actcaactca tggtgccaca
    18901 tcttaagcgc caggattttg atgcatggtc acttctccaa gaaaacacac actcggtgac
    18961 atattaatct ctcaaacttg atgctgatcc ggcatccaac gtcataatgg accgcacggt
    19021 gtaataacct ccactctgtt cacacgactg acgcatagca atgtttctta ttttgtagtg
    19081 ccaaggtctt cagtctgtta tttcttagtc tgtattactt acaagtcttt cttaacttgc
    19141 tggatcccag aaggaagagg cagctaccat cttgccaaat ggcccctcta ggctgacgtg
    19201 tgaacgttgg aggattcctg gttcatcatg acgccgcaat gatttcaaat ggggatggat
    19261 atcacagcat ttagaagaat ggcacagaaa cattgttcca gtatcataca aggctttaaa
    19321 cgattcagga ttagatgctc catgtgatgt acgtcgtcac atgctcggta tggatgtgga
    19381 gaaaagaggc gtatggaact tgacataagc tgaatactga aattgctctt gtattggtgg
    19441 tatagagcta tcaggcttgt cgcaaatatc tctcattctc tctcttcatc gttattcaac
    19501 ccgagtgatc ttcttatatc ctgacactta agacctttta ccagcctctt ttcatccatt
    19561 gcttcaatat gtggtaccat ttctttattc ttatgagtct cctcaccgct acggcgttca
    19621 gtcagccaga taattcctcc agtctatacc tcacaccatc cttgattact gaaacagcat
    19681 ccctgccgac tacgagtacg tagccaacac tcaagaaact ttggaggacg cttatgcaat
    19741 atagggtgtg cttctgtcac cgccacaagc cttggtctca caggcttgtg cgaggataat
    19801 cattgcagta cgattgagcc cttaacatta ctaaaaatgc cataaattga cgtttcgaag
    19861 gctgcagtgg tatcgcggta ccgcctttgc ctgatgtcat cactagacca tctagcaaag
    19921 gatgtagcca tcaagaccaa tttacatcac tcaactgtcc tagcaggacc gagcctgctc
    19981 ccatacctac cctgggtttc aacaattctc atacaccatt tcctaataca acattcattg
    20041 aaaacccttt gcaggacgat cagacagcga cgcggacttt cctgccaaaa gtgagcagcg
    20101 agctttctac tttggcattc agttcgacag tgcttagtgc tggtacccca tccggttcaa
    20161 cagtggagga ttattggagc tcctcggcct agtttcattg agcaccccaa ttctttcaga
    20221 atctgccagt ttcagacctt caagttccat catttctatt tcttcaagta cttctgtctc
    20281 catatcctcc agcacaatca atccggtacc tcctagcccc gttgtaccta tacatcctgt
    20341 tacaacattt caaaagccta cgtcttcaga ggaatcgctt ccattcataa catcattcga
    20401 cctcgccatc ttggccctta catccataga cccgactata tctacacata ctgcaattta
    20461 tataagtcaa ggaaattacc ctgcaggtct ttatccattc atacgaggca gcaccaaatg
    20521 cttcttttgt ccacccggta ccgaacatgg aggtttctct ctatggggaa tgaacaaacc
    20581 cgggatatac ccgccaccaa ttccaccccc agttccaaat gttcgatggc ccacgatcac
    20641 cataagccct ggaagcaagc cgactctcgg gccatttcca gaaccaaaag atcctggaga
    20701 cctatcacaa tcaagaacat caaaggaatg cacaatcact acagtatctt cttgtgctgt
    20761 atcttgcgct acaccttcag gtcaatcaac tatatcgtgc acagccacca aatgcgagac
    20821 gatcagcggc tgcagcgtgt ctaacatagc ctcaactaca acaaaatcag gatcatgtta
    20881 catcaggaac tgggccacta taaacgacca gatcgatgac tcgtctccag ggaatagagg
    20941 tgatgccggc cccgatacaa gtgatatacc cgcctcagtt ccagcaaaat cttcacaaac
    21001 agcatctgtt agctccaagg gtagtagtgg aacgacccct acaaaaactt ctagtgcagg
    21061 agcgactatg gttacctcta ctaaaaacgt tgctgtaaca accactgctg ctaggaactt
    21121 ctgtgttcct tatcagaatc ctagccgagg cgaatcatac tgtacatgcg aggaccaaag
    21181 ctcgcgcagt ttcttgtatg ataaagggaa ttgtcctacg acatcacaac cattgatttc
    21241 aacaccgaag ccaacatcgg aatctccaaa gaccgatagc agtggaaata tatggaattc
    21301 tacggacatt gttttaggca ctatatggga ctgtaagtcg acaagcattg tccgcggtct
    21361 cgccccagtt cccatcacca agtgcttgtc gagcagtagc attggaatgg acttcactcc
    21421 tacgcctgct cctcctgttt ctacattcca gcctcctcag ccaactgggc ctaagaagga
    21481 atgtgatact tgttcgagtg acatgggagc atccagctgt ggtgctaatg atctgatatg
    21541 tctcatcaat gagtgtaaag ctaacaagca ttgcaaatca tgtgggatcg actgttcctc
    21601 attccgtccg ggtagcctca gccgtgcgcg cgatttaata tatgaacgca tcttccttag
    21661 tggtcgttta aaaaagcttt ccgaaaggct ctctcgacgt aaagagatac aatcgacaac
    21721 actcacccgg attcgttcat tctttaaaag agctgagcac ggagcctcct ggaaaaagta
    21781 tgcgccgaaa ggcaagaaat actacaagat acttcaagac cagccaatgg aggatacagt
    21841 caaggccaag atgtgcgagc tggatgaata ttttaaagtc acaaagggag acgttctcgt
    21901 gccgggcctc aagaagccta tactggagaa gataaacata gtgcctacca agtcatactt
    21961 ccctatccac gctattgggc ctgtggaggg caagtctaaa gcgggagaac aaaaagaaat
    22021 ttcggatttc atgctgtcaa tttcccctga acaaggggta atatttgcca acgccgttga
    22081 aaatggtgag ataaaggtca atggagtaat aactcaaaga ggtatacctt accagctgag
    22141 taccgttgta tggtggatgt ggaagcacat agtgatgcaa ggccaaagcc ctgatactaa
    22201 agaagaggaa acggacttct ccaatgtgaa gtactttttt cattacgaca tcacaaatgg
    22261 tgagacctcg gatatcctga aagaggccat tggaaatggt cgcgagcctg tgagttttac
    22321 acctcaagac gatagcgatg acaacgcatt ttggccattg ttgggcagtc caaatggcaa
    22381 tagcatggcg tggtttttca ttgacaacaa gaagtctttg aagggaaaaa caatcgaaaa
    22441 gattactgct tggtttgatc atcgcaaaaa ctaccaactg tgggctactt tcgtataagt
    22501 aagtcccagt tcgcagtttc ataacagatg catggccaat tttaactgga tgtttttcgc
    22561 ctcttcgatt acatagatta cttgcttatt tctattttca tgtcagcgcg actatatgta
    22621 gttagcttta tgtagaagat gtataaactg caaataggta caatttattg cataacttat
    22681 agcttttcaa ttgcaatatt ctttttctat agcatgactt tctctccagg taatgaagta
    22741 gaggcaagat acttggtata gtgacgagcg ttgatattga atgctacttc taaaacgttc
    22801 aggaagggta tcttggttaa tctcaacata tgaacgcggt caattttcag tatgaaacta
    22861 cggcacctta atcaacgggg ccgtgaattg aggaggcatg tgtcatcatc gctttgatgt
    22921 gttactacct aggttctctt gtgataaact tagttcaagt tatcgaatgg gtagcactgc
    22981 gagttccatc agcgcctacg taagtgattg ctagatgaaa gcaatgcgat acttgtcgaa
    23041 attccacgtc actgaccagc gtaatgagga gctaggatta aacacaggat gttctttgat
    23101 ttttccgaaa ttccctccaa aattgactaa aagcgttata ttcctatgga tctatgacct
    23161 tctattaatc gagatgttgt cgagaacttg atacaacaac agtattgaca cggagagtgg
    23221 ggcacatagg ccctaatcag ttcgtatcga gtatagtaga atatatagtt cctgatgtgt
    23281 gcattcagaa atctatgtat aaacaacttc tttttacgag gtgaatgttg cttatctagt
    23341 tgcatcaaga cttcctgtat tgatctctgc cgtgaattag agactttgac tttgttgatc
    23401 ataatcaagt cgatctgccg tgagacagtt tttagaaaga acattccaag agcgcaaagg
    23461 tcatggagac ggctgaagct cgttctaggt tcgccctgcc gatccggatg gtgatataag
    23521 ttgtattctg ggtcatcctt aaaatcaagt tttgtgtggc tggcttgcgg tctggagtcc
    23581 tcgagattgt tagatacagg caaaagatca gttaaaaaac caaaagagct ttgatcggcc
    23641 actaaaattt tggatatcat acaagataag tcaccaagta atgatattgc ccttctactt
    23701 aaacttctat agagaggagt aacacgagct gatttactag ctttctaaag ttactcttaa
    23761 ctctattctt gcaaggaggc tagcgcaaag atctcttgat tgtataagat ctgtattccc
    23821 gcctttgtct atgagcgtac ccaagccctc aataagtgcc cgaaacatgt ccaggtcact
    23881 ttcttgaaga acagcagatt caggagcgtg cgcatgatgc gcgagaactg taatcagagc
    23941 tacttggaaa gccttgtact cgttccagta gagtgcgacg tcgccccttg gtgcgatagg
    24001 aagaagactg agaagcctgc gagcctcatg gtagctcttc tgctctgtca tctgcgatag
    24061 acgggtcata cccattaaag agaaggggtt cactctgtgg ttcttatcaa aggctaggaa
    24121 agcttgtagc cgatggacgg tcatgaaata acctgactcg aggctgactg tatgtgcaat
    24181 gtctgagcga taaaggagat gggacatttg ttctgggccc agcgagaaga gtttgtggtt
    24241 atggaaaccc ttcagacgcg caagaacagc tgcagcagcg gcttcgatgt ctattgcctt
    24301 gttctgagcc tttgctgata acacttgttc aacagcttct gcttgtagta atgctaattc
    24361 tacccgcagt aagaagaagt tgaccttcca gaaaccctct gccgccacga tttcgccaac
    24421 gttatcggct ggattcaaag ctggcttcgg cgcgatgatg tcatctcgac gatgagttgt
    24481 tggggtgttt gaagctatcg ctgtgtacgt atcgcatatg aaagataacc agaagactct
    24541 ccgttcttgt tcaatatcgc gggtagagtc tggtagttcg ggctcctcct catgatatgc
    24601 aagactctgc gcgacacgca atgatgttga aagtagaggc ccatctgcga gattgcagcc
    24661 acattgtgtt gaccttataa gtttcgcagc accaatgaga cactgtacaa gcccaagtga
    24721 cgggtgcgat aagagaagat gattcagatt tgaatagatt cgggatacat agtacttggc
    24781 tagttccata tctgcaggtg tcgcagttat gctcatcgct cgaagggtgt gtgcaagccc
    24841 gaacacaaca tacgcgctgg tccatgatac ggggtgatct tgggctgcgt ggccagcata
    24901 gcaaattcgt agatggttac tgatatcatg aggtcgataa agaggatagg cggtgttgaa
    24961 atcgacaaga aattcagaga gcaaagcggt gcccaaggtt gggggcggta aatattcttc
    25021 acaagcattg attgttatcg ggaaatgtgg cgagtctgta ctatgtcgtg ataggagtgt
    25081 ctcattgacg atattgccac atggtagatt ggaagtatct tttctgacgg tgggtgatgg
    25141 tcccgagctg tcgcctttag ggacgttcga gcagctgacc ccaatctctc ctgggaggga
    25201 aggaacattt tgagaattcg aatttcgatt gcagtgcgcc aaggaagatg agtcggtgaa
    25261 atctttgaac aaaagacttt cgaaatcaag ataatcccgc tgcacgatag tgtcgatact
    25321 gttgcgtaaa ttggctaccc acttggctgc gggcacaggg tcatttgctg gttgtaatgg
    25381 ctgctgctct aattgcggct gttctgcgct gcgctcttgt agcagagatt ctagtctctt
    25441 tactctgctt tcatattcag cgatacgatt gctagattgt tctcgagatt agctcccatc
    25501 acgaatgggg acaatgtaca ttcatactct ctttgaggcc tggctctctg tttacgaaca
    25561 tgcgtcgtcg tacagatctc gttgtatctg gtgcatattg tacagcttga tatgccagca
    25621 tcccatatac atcttcgctt cctctttcgg cagatatcgc aagcctatgg attcattagc
    25681 gctggtacct accggcctgc ctcttggtat tgacgacgtc gttgaccgaa gactgcttgg
    25741 cagtaaatca cgagaacgtg gagtgttgag acgaaagatt catgcttacc cgcacggtag
    25801 cagcgcagcc acgtttttca agaccagtcg ccatctgtga cgaaatctag cattatgttg
    25861 caaaacaata aggcgatgta gatagcagta cgtaggcgcg tatcacaatg cgttatgtgg
    25921 ggaagtgtga tgccacgcca cagcttgggg gattactaat gcagagatgg acacccctat
    25981 cgtaacacaa cctccctact c
//
