LOCUS       BGC0000813             20300 bp    DNA     linear   BCT 14-JUN-2007
DEFINITION  Nonomuraea longicatena K-252a biosynthesis gene cluster, complete
            sequence.
ACCESSION   BGC0000813
VERSION     BGC0000813
KEYWORDS    .
SOURCE      Nonomuraea longicatena
  ORGANISM  Nonomuraea longicatena
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Streptosporangiaceae; Nonomuraea.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:15:15
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20300
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..885)
                     /gene="inkT"
     CDS             complement(1..885)
                     /codon_start=1
                     /gene="inkT"
                     /note="K-252a biosynthesis; putative bacitracin resistance
                     protein"
                     /product="InkT"
                     /protein_id="ABD59203.1"
                     /transl_table=11
                     /translation="MADTLAIVTGTTERGEDVISWFEAVILGLVQGLTEFLPISSTAHI
                     RVVSAYAGWGDPGAAFTAVIQLGTEAAVLIYFRRELWEILSTWTRSLFDRELRHAFPAR
                     MGWYIILGTLPIGVLGLVLKTQIETVFRDLRIVGTTLIVFALILWFADRTARNKLTLEK
                     HLSPVHAIVYGFAQSLALIPGVSRSGGTITAGLLLDYRREDAARYSFLLAIPAVLASGF
                     LELAEIGGGRAPDWGPTLLATGISFAVGYAAVSWFLKYISTHRFTGFVVYRIVLGLFVI
                     LSVNLGWIPAQGG"
     source          1..20300
                     /db_xref="taxon:83682"
                     /mol_type="genomic DNA"
                     /organism="Nonomuraea longicatena"
     misc_feature    1..20300
                     /note="K-252a biosynthesis gene cluster"
     subregion       1..20300
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000813"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20300
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="indole"
                     /region_number="1"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(908..1714)
                     /gene="inkH"
     CDS             complement(908..1714)
                     /codon_start=1
                     /gene="inkH"
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 194; E-value: 6.3e-59)"
                     /gene_kind="other"
                     /note="K-252a biosynthesis; sugar epimerase"
                     /product="InkH"
                     /protein_id="ABD59204.1"
                     /transl_table=11
                     /translation="MTNTTLVLGSNGKTGRRVAERLRATGRQVRAGSRPAFDWEDERTY
                     APVLRDVSAVYITYYPDLAFPGALGRIAALTEQAVAAGVGRLVLMSGRNEELAQRAERI
                     VLDAGVEATVVRCSWFMQNFSEGWLLDPVLSGTVALPAGAVTEPFVDADDIADVAVAAL
                     TEPGHAGKVYELTGPRLMSFAEAAAEISAASGREVRYAPVTPAEFAAGAVAAGVPEDTA
                     HGLNALFAEVLDGRNESLADGVRQALGRPPRDFAEYAAKAATTWQR"
     gene            1790..2692
                     /gene="inkR"
     CDS             1790..2692
                     /codon_start=1
                     /gene="inkR"
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 306.9; E-value: 2.2e-93)"
                     /gene_kind="regulatory"
                     /note="K-252a biosynthesis; transcription regulator"
                     /product="InkR"
                     /protein_id="ABD59205.1"
                     /transl_table=11
                     /translation="MDQLAALLDGPRARGAFLLRAHLDPPWSMRVQDEAPLTLVAVVKG
                     EAWIGESTRLRPGEVAVVRGPQPYVVADRPGTPPQVVIHPGQRCTTLDGQSLFESMLLG
                     VRTWGNSGAGGATAMLVGTYQLEGEVSRRLLDALPQLIVLPGGPLIGLLGQEVVKDEPG
                     QETVLDRLLDLLLISTLRTWFAEHETPAWYRAMGDPVVGRAMRMLHDDPARAWTVAALA
                     AEVGVSRASLARRFTDLVGEPPMSYLTDWRLALAADLLREPGATVGSVARKVGYGTPFA
                     LSAAFKRVRGVSPQEYKAG"
     protocluster    2394..20300
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[12393:15489]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      12394..15489
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     cand_cluster    2394..20300
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     gene            complement(4113..4961)
                     /gene="inkL"
     CDS             complement(4113..4961)
                     /NRPS_PKS="Domain: NAD_binding_4 (52-140). E-value: 4e-08.
                     Score: 24.5. Matches aSDomain:
                     nrpspksdomains_inkL_NAD_binding_4.1"
                     /codon_start=1
                     /gene="inkL"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 81.3;
                     E-value: 1.4e-24)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; dTDP-dihydrostreptose synthase"
                     /product="InkL"
                     /protein_id="ABD59206.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 3.2e-98, bitscore:
                     318.2, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRWLVTGGAGMLARDVLGRAALIGDPVLAPGRAELDLCDGRAVRE
                     LVGSYRPRVVVNCAAWTAVDDAEAHEAEALAVNGHAVRVLAEACARSGARLLHLSTDYV
                     FDGASAAPYREDAPTGPVNAYGRTKLAGEAAALEHGQYVVRSAWLYGAGGANFARTMIR
                     LAGQVQTVDVVDDQRGQPTWTEDLADFLVRLALSDLPPGVYHGTSAGATTWYGFAREIF
                     TLLGADPGRVRPVAGAALGRVARRPASSVLAHTRWEPIRHWRAALHAAWPVLATEPAAF
                     R"
     aSDomain        complement(4542..4805)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_inkL_NAD_binding_4.1"
                     /evalue="4.00E-08"
                     /label="inkL_NAD_binding_4.1"
                     /locus_tag="inkL"
                     /protein_end="140"
                     /protein_start="52"
                     /score="24.5"
                     /tool="antismash"
                     /translation="RVVVNCAAWTAVDDAEAHEAEALAVNGHAVRVLAEACARSGARLL
                     HLSTDYVFDGASAAPYREDAPTGPVNAYGRTKLAGEAAALEHG"
     gene            complement(4958..5872)
                     /gene="inkB"
     CDS             complement(4958..5872)
                     /NRPS_PKS="Domain: NAD_binding_4 (54-167). E-value:
                     4.8e-10. Score: 30.8. Matches aSDomain:
                     nrpspksdomains_inkB_NAD_binding_4.1"
                     /codon_start=1
                     /gene="inkB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     314.6; E-value: 1.3e-95)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; putative dTDP-glucose
                     4,6-dehydratase"
                     /product="InkB"
                     /protein_id="ABD59207.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4e-20, bitscore:
                     61.9, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.5e-15,
                     bitscore: 46.2, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGGAGFIGSHFARGLGGAEVTVLDKLTYAGNRANLDGVPHAFVH
                     GDICDAGLLREVLPGHDLVVNFAAESHVDRSIEGAAEFVRTNVLGTQTLLQGCLEAGVR
                     KVVQVSTDEVYGSIGVGSWTESAPLRPRSPYAAAKAGGDLVAQAYAITHGLDVSITRCG
                     NNYGPRQYPEKIIPLFVTRLLRGERVPLYGDGGNVRDWVHVADHCAGIRLVAEVGLPGE
                     VYHIAGTAEMTNKELVGHLLAASDADWGRVEYVEDRKGHDRRYSLDDRRLRALGYRPEV
                     EFDQGLRDTVRWYAANPGWWAGS"
     aSDomain        complement(5372..5710)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_inkB_NAD_binding_4.1"
                     /evalue="4.80E-10"
                     /label="inkB_NAD_binding_4.1"
                     /locus_tag="inkB"
                     /protein_end="167"
                     /protein_start="54"
                     /score="30.8"
                     /tool="antismash"
                     /translation="REVLPGHDLVVNFAAESHVDRSIEGAAEFVRTNVLGTQTLLQGCL
                     EAGVRKVVQVSTDEVYGSIGVGSWTESAPLRPRSPYAAAKAGGDLVAQAYAITHGLDVS
                     ITRCGNNYG"
     gene            complement(5884..6993)
                     /gene="inkA"
     CDS             complement(5884..6993)
                     /codon_start=1
                     /gene="inkA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 241.4; E-value:
                     2.1e-73)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; glucose-1-phosphate
                     thymidyltransferase"
                     /product="InkA"
                     /protein_id="ABD59208.1"
                     /transl_table=11
                     /translation="MTQTCPLPEFPFVRSSALDADARGIELLGDAPVVRARYRDGGELW
                     VALGNEAARQVVTDPRFSRHAAVEPDGPKIEAAVGDGSAFGLRATYLRQRAPLGLAHAV
                     SIARDFLGDDDFVMYLGDNFIVGGIDALVERFARVRPAAQIMLTRVGDPSQFGVAELDA
                     DGRVVSLAEKPAHPKSDLALVGVYLFTPAVHAAVAGLKPSWRGELEITDAIQWLIEAGL
                     RVDSSVISGYWKDTGNVADMLEVNRLVLESLEPRTDGRVDGSELIGRVVVERGAVVERS
                     RVVGPAIIGAGARVEASYVGPFTSIGAGCVVARSEIEYSIVLPRASIDGVGRIEASLIG
                     HDVEVTPAPSTPRAHRLVLGDHSKVQISS"
     gene            complement(7007..8140)
                     /gene="inkM"
     CDS             complement(7007..8140)
                     /codon_start=1
                     /gene="inkM"
                     /note="K-252a biosynthesis; methyltransferase"
                     /product="InkM"
                     /protein_id="ABD59209.1"
                     /transl_table=11
                     /translation="MTVTSASVVAVAALPEHEAHAAVAALGPAEVAEIVLAEVAALTGV
                     LPGPEEKVPVQFDLGFGGGRLAYTLTVGGGAASVAAGPLAEPDVVIRQELTELLRSVYG
                     EAGVHDATREIFLNAPDGPPGSDPTGRLARRRAAAVAAARSASLAATQNPVDLTELAIR
                     TGTDKWGRHWYTGHYQQHFRRFRDSRVRVLEIGCDGGESMRMWTHYFRRGEVIRMDAKD
                     KALTAPQRARSVFGAQDDLDFLARVAAEHGPFDLVIDDGSHVNDHVLTSFRILFPHLRA
                     GGLYVIEDLGASYWPGWGGSSTELSTPATTVGFVKELIDGLNHQQLVRDVEHDPSLTDR
                     TVSGISLHHNIAFVHKGRNTERGAPAWVTRAESALFL"
     gene            complement(8137..8652)
                     /gene="inkY"
     CDS             complement(8137..8652)
                     /codon_start=1
                     /gene="inkY"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 147.3; E-value: 1e-44)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; cytochrome P450"
                     /product="InkY"
                     /protein_id="ABD59210.1"
                     /sec_met_domain="p450 (E-value: 1.8e-20, bitscore: 62.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGYESTASLISAGILEALGRDAGARPRTPEQIDGWIEETLRVHP
                     PFPHATWRFATEDVNLGGYLIPAGAPVQINVAAANRCPHHERTGEFDPEAGRGHISFGL
                     GHHYCLGAPLARLEARIALTAFFRRFPHARLSERTEVGWESEWMTRRISVLPVVLAGPT
                     PNPEGMTP"
     gene            complement(9364..10515)
                     /gene="inkG"
     CDS             complement(9364..10515)
                     /codon_start=1
                     /gene="inkG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 223.9;
                     E-value: 6.7e-68)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; N-glycosyltransferase"
                     /product="InkG"
                     /protein_id="ABD59211.1"
                     /sec_met_domain="MGT (E-value: 1.8e-48, bitscore: 155.6,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFAAHDFSGQSKAEAFPAQARLTGAASFVAGMRDIFYRTAPDQMD
                     DLLRVLDRFPADVLVSDDMCYGASFAAEHTGLPHVWIGNSIYVLGSRDTAPLGRGLGPS
                     ATRAGRLRNAVLAWAGDHIMLRGLRRAADAARAQAGLARLRAGGMENIARRPDRYLVGT
                     VAELEFPRSDLFAGTHFVGALDLPPSDTAFDPPPWWEELRGERPVVLVTQGTIADDARR
                     LLLPAIRALADEPVLVVVTTGNRTLGPSAGTLPANVRVEGFVPYHRLLPYVDVMVTNGG
                     FNGVTAALRHGVPLVVAGATEEKADVAARVAYAGAGVALRGARLAPERVRAAVRAVLDG
                     PEHRAAAARLHDAFARHDGPRRAAELIEELIPARTAPATGGPL"
     gene            10937..12397
                     /gene="inkO"
     CDS             10937..12397
                     /codon_start=1
                     /gene="inkO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; L-amino acid oxidase"
                     /product="InkO"
                     /protein_id="ABD59212.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.9e-09, bitscore:
                     27.0, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSRLPNVREPRRVTVLGAGVAGLVAAYELERLGHQVEIIEAADR
                     VGGRVHTHRFGSAPGAPFADLGAMRLRTDHTRTLHYVVELGLHNDIREFRTLFADDGNL
                     LSIHDERHIRVREAPDVLTGRLAARLGDHSYRPATLLFGAWLHACLEAIAPRDFNDWPE
                     VTTELLDLVDGIDLEPYLHPAGSKPDLYAVVKDHPQIRSGPFRGRERLLDDVLDETSPA
                     LYRLRGGMETLTNALAARIQGPIWLNQEVTGIAVHDDGVAVGVRRGGRIRYRNYDHVLC
                     TIPFTVLRGLRLDGFDADKLAAVHETQYWPATKIALRCREPFWAADGIAGGASFTGGLV
                     RQTYYPPVEGDPAQGAVLIASYTIGPDAEALGRLDPAARRQVVLDEVARMHPGLRERGM
                     ILDTAGRAWGEHRWSLGAATIRWGQDAGTRKEQQWAAARPQGRLFFAGEHCSSMPAWIE
                     GAIESVTDALRDMETRDPHELMRLDLGR"
     gene            12394..15489
                     /gene="inkD"
     CDS             12394..15489
                     /codon_start=1
                     /gene="inkD"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indsynth"
                     /gene_kind="biosynthetic"
                     /note="K-252a biosynthesis; CCA synthetase"
                     /product="InkD"
                     /protein_id="ABD59213.1"
                     /sec_met_domain="indsynth (E-value: 0.0, bitscore: 1445.2,
                     seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFSLPRLHFAGLATTQLPTGPRQGLTDLATNGALCADGTPFPP
                     GRPPAEYDGPRGEHFAGNGHFAVPSAAITGVELRAGEVDTADPVVGRQVDLWGHYNEYL
                     QTTVNRGRVFDVDPASNWTTTVMVGQFGFGRAGRSHDTGYALVGDVHGYQPPRWQDLRR
                     GTVVHQFAVAREEIAWPAPVAGSEAVAALARALAGSDGLVVQFALLAPDGPRLPDAPRS
                     WELRGTIAPWWRAEPRTFPAGRLMLPVEPGVRVFSVDVGAEYVTLNLVTAAASLPPGEV
                     ELRTARTGKLVAAVPVRSCRESARHGGLVCATRLGEAEDEALVLVAARDGRVLAREQEV
                     VLQADDACQVLDHPRHAGDDSCDAEVGFRSFVRGRPAPVAVVRVRQFPNPRALPLAPDA
                     ATAEIVHVADPERTGPESTDTLSTDTLSTDTLSTDTLSIDPPSIDTVSTDAGGFGRLTL
                     RGLRPGSTRLLLGGDATGVHYDNDDELGFWAGAGGVHVRVLPDDWRLADLRDDEVTFET
                     VYREVFAPYEAQYSFMREEVFSLADRCKVETYAKLVWQMCDPRNKATTYYMPPTRDLTA
                     PKAALLLRYLRRVQRPDHVLLRAETPAARPGLATRAELVAALRDAVKLELAVMIQYLYA
                     AYTVPDHGAGREYVRRGDWTPEQLALACGDGGETLAGGIRGTLIRVAREEMIHFLLANN
                     ILMAIGEPFHLPHLDFGTLNAELPIALDFSLERLDVASVARFVRIEEPDGLVTPVRLGT
                     RTSTGTSTSADADADADGDGGEPGYASISELYGDIRRALTTIPGLFLTEPGRGGGEHHL
                     FLRKRVNDHHPDYQLEVDDLASALFAIDVITEQGEGGELTDGDEPSEESHHAAFLGVAE
                     ALRRSDWVPSYPAARNPTLRRGDRARQYIPDPDARRVMRLFNAAYAVALQLMVQHFGAG
                     PDTSLRRSKLMNAAIDVMTGVLRPLGELLTTMPSGLRGRTAGPSFELDAPPAFIARPDV
                     AALRVARQLDDVAAAASACPPVPARVAEISTLLAEQLRGSVR"
     gene            15486..17063
                     /gene="inkE"
     CDS             15486..17063
                     /codon_start=1
                     /gene="inkE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 305; E-value:
                     1.8e-92)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; monooxygenase"
                     /product="InkE"
                     /protein_id="ABD59214.1"
                     /transl_table=11
                     /translation="MTRSEETDVLIVGGGPVGLALSLDLTHRGVRHIVIDAGDGVVRHP
                     KVSTVGPRSMEHFRRWGVAGRVRDAGWPPGHPLDIAWVTRVGEYEIHRFERGTAAARPV
                     FRHTPEPDQVCPAHLLNPVLAGAVGRPLRYLHRLEHFEQDAGCVRATISSNGEESVVWA
                     RYLVACDGSSSVVRKALGIDSPARHEAQVFRNVLFRAPGLPARLAERGHRSALVYYLMH
                     SWSLRYPMRSLDGRGLYNMVVDGRSDQGALELIRSAIAFDVPVELVADGLWHLTHRVAD
                     RYRAGRVFLAGDAAHTLSPSGGFGMNTGIGDAADLGWKLAAAVAGWAGDGLLGTYETER
                     RPVAIAGLDAAEANLRRTVDRDLPAELAASTEKGARLRAEMAERLVNSGAREEFDAPRV
                     HFGFHYRSPIVVSDGPAEQGPRWRPGSDPGCRAAHAWVRPGVSTLDLFGDGFTLLRFAD
                     SPALSAFVTAFTERGVPFRSVLVGDPDTAALYGHRFVLVRPDGHVAWRGDDLEAAPANL
                     ADLVRGAG"
     gene            17063..17590
                     /gene="inkP"
     CDS             17063..17590
                     /codon_start=1
                     /gene="inkP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 107.8; E-value: 9.9e-33)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; cytochrome P-450"
                     /product="InkP"
                     /protein_id="ABD59215.1"
                     /transl_table=11
                     /translation="MEPFSPLGWSPADLADPYPIYRRYREADPVHRAGPGTWFVFDHEH
                     VAQTLSRRDFGRNRPAHLPGRNDALYRSVRDWLVFLDPPRHTRLRRLLAAEFSPKVVAG
                     LRPRIASIVASLLRPLWGREEFDLVREFAAPLPVLVITKVPRLANPFVSSRTPYARATC
                     PCGQKSDSNGNV"
     gene            19482..20300
                     /gene="inkU"
     CDS             19482..20300
                     /codon_start=1
                     /gene="inkU"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1091:glutamine-binding lipoprotein glnH (Score: 182.1;
                     E-value: 1.7e-55)"
                     /gene_kind="biosynthetic-additional"
                     /note="K-252a biosynthesis; ABC-type amino acid transport"
                     /product="InkU"
                     /protein_id="ABD59216.1"
                     /transl_table=11
                     /translation="MRRLPIAALTPLTLLALLGLLAGCGATGDGVLSADTVRVAVRVDL
                     PGIGARGPSGAVEGFDVDVARYLVGKLGKKAVFVPVTAADREKVLTSGRADMVLATFSI
                     TQDRKERVLFAGPYQLSYQDILVRRGETRIKNVRDLAGRSICEVKGSNAGQRVVEERKV
                     AARLVPFDSYGPCMERLLSGEVDAVTTNDVILAGLAAESSGLRLVNAQFNEQRTGVGMR
                     LGDVEGCEAVNRAITGMYQDGTAKKLLKKWFGKTDLPISTVSVPQFEGCS"
ORIGIN
        1 tcagcctccc tgagccggaa tccagcctag gttcacggac aggatgacga agagcccgag
       61 gacgatccgg tagacgacga acccggtgaa gcggtgggtg ctgatgtact tgaggaacca
      121 ggacacggcg gcgtacccga cggcgaagga gatgccggtc gccagtagcg tcggacccca
      181 gtcgggcgcg cgaccgccgc cgatctcggc gagttcgagg aaaccggagg ccagcacggc
      241 ggggatggcc agcaggaagg agtagcgggc cgcgtcctcg cgccggtagt cgagcagcag
      301 gcccgccgtg atggtgccgc cggagcgcga gacgccgggg atgagggcca gcgactgcgc
      361 gaagccgtac acgatggcgt gcaccgggct caggtgcttc tccagggtga gcttgttgcg
      421 ggcggtgcgg tcggcgaacc acaggatgag cgcgaagacg atgagcgtgg tgccgacgat
      481 ccgcagatcg cggaagacgg tctcgatctg cgtcttgagg accaggccga gaacgccgat
      541 gggcagggtg ccgaggatga tgtaccagcc catccgagcc gggaaggcgt ggcgcagctc
      601 gcggtcgaac agcgacctgg tccaggtgga caggatctcc cacagttccc tgcggaagta
      661 gatgagcacc gcggcctcgg tgccgagctg gatgaccgcg gtgaaggcgg cgcccgggtc
      721 gccccagccg gcataggcgg agacgacccg gatgtgcgcg gtcgaggaga tcggaagaaa
      781 ctccgtcagg ccctggacca accccaggat caccgcttcg aaccagctga tcacgtcttc
      841 gcccctctcc gtcgtcccgg tgacgatggc gagggtatcc gccacggagc gtgatcggcg
      901 ccaggcgtca cctctgccag gtcgtggcgg ccttcgccgc gtactcggcg aagtcgcgcg
      961 gcggccggcc gagggcctgc cgtaccccgt ccgcgaggct ctcgttgcgt ccgtcgagga
     1021 cctcggcgaa caaggcgttg aggccgtgcg ccgtgtcctc cggtacgcct gcggccacgg
     1081 cacccgccgc gaactccgca ggcgtcaccg gcgcgtagcg gacctcgcgc ccgctcgcgg
     1141 ccgagatctc ggccgcggcc tcggcgaacg acatcaggcg cggcccggtg agctcgtaca
     1201 ccttgcccgc gtggccgggt tcggtgaggg cggcgacggc cacgtccgcg atgtcgtcgg
     1261 cgtccacgaa cggctcggtc accgcgcccg cgggcagtgc gaccgtgccg ctgagcaccg
     1321 ggtcgagcag ccagccctcg ctgaagttct gcatgaacca ggagcagcgc acgacggtgg
     1381 cctcgacccc ggcgtccagg acgatccgct cggcccgctg cgccagttcc tcgttgcggc
     1441 ccgacatcag cacgagcctg ccgaccccgg cggcgacggc ctgctcggtg agggcggcga
     1501 tccggcccag cgcccccggg aaggccaggt cggggtagta ggtgatgtac acggcggaga
     1561 cgtcgcgcag cacgggcgcg taggtgcgct cgtcctccca gtcgaaggcg ggacgggagc
     1621 ccgcccgcac ctgccggccc gtcgcgcgca ggcgctccgc cacgcggcgc ccggtcttgc
     1681 cgttcgatcc cagaaccaag gtggtgttcg tcatgtgtcc cagtgaatcg ccacagggtg
     1741 agacttgaca tagttgaaac tcgcgattcc atatgcaatc gtctcaaata tggatcagct
     1801 tgccgcgttg ctcgacgggc cgagggccag gggtgccttc ctgctccgcg cccacctcga
     1861 cccgccctgg tctatgcggg tgcaggacga ggcccctctc acgctggtcg ccgtcgtcaa
     1921 gggggaggcg tggatcggcg agtccacccg cctgcggccg ggtgaggtcg ccgtggtgcg
     1981 ggggccgcag ccgtacgtcg tggccgaccg gccgggcacc ccgccgcagg tcgtcatcca
     2041 ccccggccag cgctgcacca cgctcgacgg gcagtcgctc ttcgagtcga tgctcctcgg
     2101 cgtgcgcacc tggggcaaca gcggcgcggg cggcgccacg gcgatgctcg tcggcaccta
     2161 ccaactggag ggagaggtca gcaggcggct gctcgacgcg ctccctcagc tcatcgtgct
     2221 gccgggcggg ccgctcatcg ggctgctcgg gcaggaggtc gtcaaggacg agccggggca
     2281 ggagaccgtc ctcgaccggc tgctcgacct gctgctcatc tccacgctgc gcacctggtt
     2341 cgccgagcac gagacgcccg cgtggtaccg cgcgatgggc gacccggtcg tcggccgggc
     2401 gatgcggatg ctccacgacg accccgcccg agcctggacg gtcgccgcgc tggccgccga
     2461 ggtcggcgtc tcccgcgcct cgctggcccg gcgcttcacc gacctggtcg gcgagccgcc
     2521 gatgtcctac ctgacggact ggcggctcgc actggccgcc gacctgctgc gcgagcccgg
     2581 cgccaccgtc ggctccgtgg cgcgcaaggt cgggtacggc accccgttcg cgctcagcgc
     2641 cgccttcaaa cgggtgcgcg gagtgagccc acaggagtac aaagcaggat gagacccctc
     2701 ctgttggtgg acgtggacgg cgtgctgaac ccgctgggac ctctcagcgc ggacttccgc
     2761 cgctaccgtt gccccctgga aggccccctc ggtagcgagg tgtacaccgt gcatctcaac
     2821 caccggcacg gtacccggct gctcgaactc gccctgcgca ccggcgccga actggtgtgg
     2881 gcgacgacct gggaggagca cgccaacgag tggatcgcgc cccggatcgg gctgccccgg
     2941 ctgccggtga tccccgtcgg gaccgcgcac ggcacgacgc ggggggagat gttcaagacg
     3001 ccgggcgtgg ccgactacgt ggcggggcgg ccgttcgtct ggttcgacga catgatccac
     3061 gccgccgacg acgcctatct gcgggcgcac cccggggtcg gcgccttcct gctggtccag
     3121 gtggacccca ggcagggcct tgaccagcgg catcttgacc tcgcggccga atggctgacc
     3181 ctgtcagggt tttctcaggg tcgctgaagg aacgcgggaa agtgggtaag tcgttctacc
     3241 ggatgagttc gcaaaccaca cggaggaacg agatgtaccg ctccaaggag cacaagatca
     3301 tcgctggcgt ctgcggtggc atcgcggaca agctgggctg gtcgccgacg ctcgtgcgtg
     3361 cgctctggct gctgctgtcg cttttccccg gcccgatgtg ggtcctctac gtcattctgt
     3421 ggatcgtcct gcccgcccgt tcccggagct acgctggatg acatgaagcc acgcccgctc
     3481 acgctcatcc acgacgacct cgtcgactac gacgcggcta tggagcgcat gaccgacctc
     3541 gtcggccggc gccagcgaga cgagcgggcg gacacactct ggctgctcag ccacccgatg
     3601 gtgttcaccg tcgggcggcg cacacccgaa tcccacctgc ccgatccgac ccacggcgta
     3661 cccgtggtcg agacgggcag gggcggccag ctgacctacc acgggcccgg ccagctggtc
     3721 ggctacctca tcgtcaagct cgccgaggac gagggcatcg tcgactacgt ccgcgaggtc
     3781 gagctgcgcc tggtggaggc gctcggcaag ctgggggtgc ccgccgagcg ccgcgacacc
     3841 ccgccgggcc acgaactcct caccggcgtc tggaccaccg ggaccagccg gaagatcgtc
     3901 tcgatcggca tgcggcagag caggggggtg accagccacg gcttcgccct caacgtcgac
     3961 ggcgacctta cgccgtggcg ctgggccgtg gcctgcggca tgccggacgt cgacatgacc
     4021 tcggtccggc gcgagctggg cccggcgtcc atggcctcga tggacacagt ccgagagacg
     4081 gtggcggcgg ccttcgaggc ccgcccctga cctcagcgga aggcggcggg ttccgtcgcc
     4141 agaacaggcc aggcggcgtg cagcgcggcc cgccagtggc ggatcggctc ccaccgcgtg
     4201 tgcgccagca cactgctggc cgggcgccgg gctacgcggc ccagggcggc gcccgccacc
     4261 gggcgcaccc tgccgggatc ggccccgagc agggtgaaga tctccctggc gaagccgtac
     4321 caggtggtcg ccccggcgct cgtgccgtgg tacacgcccg gcggcaggtc cgacagcgcc
     4381 agcctgacca ggaagtcggc caggtcctcc gtccacgtgg gctggccgcg ctggtcgtcg
     4441 accacgtcca cggtctggac ctgcccggcg agcctgatca tcgtgcgggc gaagttggcg
     4501 ccaccggccc cgtacaacca ggcgctgcgc accacgtact ggccgtgctc cagcgccgcc
     4561 gcctccccgg ccagcttggt cctgccgtag gcgttgaccg gccccgtcgg cgcgtcctcc
     4621 cggtacggcg ccgcgctcgc cccgtcgaac acgtagtccg tggacaggtg cagcagccgg
     4681 gcgcccgaac gcgcgcacgc ctcggccagc acccgcaccg cgtggccgtt gacggccagc
     4741 gcctcggcct cgtgggcctc ggcgtcgtcc acggcggtcc aggccgcgca gttgacgacg
     4801 acccggggcc ggtaggagcc caccagctca cgcaccgcgc ggccgtcgca caggtcgagt
     4861 tcggcccggc cgggcgccag caccgggtcg ccgatcagcg cggcccggcc gagcacgtcg
     4921 cgggccagca tcccggcgcc gccggtgacg agccatctca tgacccggcc caccagccgg
     4981 ggttggcggc gtaccagcgc acggtgtcgc gcagcccctg gtcgaactcg acctcggggc
     5041 ggtagcccag cgccctgagt cggcggtcgt cgagcgagta gcggcggtcg tggcccttgc
     5101 ggtcctcgac gtactcgacc cgcccccagt ccgcgtcgga cgccgccagc aggtgcccga
     5161 ccagctcctt gttggtcatc tccgcggtgc ccgcgatgtg gtacacctcg ccgggcaggc
     5221 cgacctccgc caccaggcgg atgcccgcgc agtggtcggc gacgtgcacc cagtcgcgca
     5281 cgttgccgcc gtcgccgtag agcggcaccc gctcgccgcg cagcagtctc gtgacgaaca
     5341 acgggatgat cttctccggg tactgccggg gcccgtagtt gttgccgcac cgggtgatcg
     5401 acacgtcgag gccgtgggtg atcgcgtagg cctgggcgac caggtcgccg cccgccttcg
     5461 ccgccgcgta cggcgagcgc ggccgaagcg gcgccgactc cgtccacgag ccgacgccga
     5521 tcgagccgta cacctcgtcg gtggagacct ggacgacctt gcgcacgccc gcctccaggc
     5581 agccctgcag cagggtctgg gtgcccagca cgttcgtgcg cacgaactcg gccgccccct
     5641 cgatcgaacg gtccacatgg gactcggcgg cgaagttgac caccaggtcg tggccgggca
     5701 gcacctcgcg cagcagcccg gcgtcgcaga tgtcgccgtg gacgaacgcg tgcggcaccc
     5761 cgtccaggtt ggcccggttg ccggcgtagg tgagcttgtc gagcacggtc acctcggcgc
     5821 cgcccagccc gcgcgcgaag tgcgagccga tgaacccggc cccgccggtc accaggatct
     5881 tcttcatgag ctgatctgca ccttgctgtg atcgcccagc acgaggcggt gggctcttgg
     5941 ggtggagggc gcgggtgtga cctcgacgtc gtggccgatc agcgacgcct cgatgcggcc
     6001 cacgccgtcg atggaggcgc gcggcagcac gatcgagtac tcgatctcgc tgcgggcgac
     6061 gacgcacccg gcgccgatgg aggtgaacgg gccgacgtag ctggcctcga cgcgggcccc
     6121 ggcgccgatg atcgccgggc cgacgacccg ggaccgttcg accacggcgc cgcgttcgac
     6181 gaccacccgg ccgatcagct cgctgccgtc cacccggccg tcggttctcg gttccagcga
     6241 ctccagcacc agccggttga cctccagcat gtcggcgacg ttgccggtgt ccttccaata
     6301 gccggagatc accgaggagt cgacccgcag gcccgcctcg atcagccact ggatcgcgtc
     6361 ggtgatctcc agctcgcccc gccacgacgg cttcagcccg gccaccgccg cgtgcacggc
     6421 cggggtgaac aggtagaccc cgaccagcgc caggtcgctc ttggggtggg cgggcttctc
     6481 cgcgaggctc accacgcggc cgtcggcgtc cagctcggcg acgccgaact gggacgggtc
     6541 gccgacccgg gtgagcatga tctgggcggc cggccggacc cgggcgaacc gctccaccag
     6601 ggcgtcgatg ccgcccacga tgaagttgtc gcccaggtac atgacgaagt cgtcgtcgcc
     6661 gaggaagtcc ctggcgatcg acaccgcgtg ggccagcccc agcggcgccc gctggcgcag
     6721 gtaggtggcc cgcagcccga acgccgaccc gtcgccgacg gccgcctcga tcttcggccc
     6781 gtccggctcg acggcggcgt gccgggagaa gcgggggtcg gtgacgacct gcctggccgc
     6841 ctcgttgccg agcgccaccc acagttcgcc gccgtcgcgg tagcgggccc gcacgaccgg
     6901 cgcgtcgccg agcagttcga tgccccgcgc gtcggcgtcg agcgcgctcg accggacgaa
     6961 cgggaactcc ggcagcgggc aggtctgtgt catcgtcggt ctcccgtcac aggaacagcg
     7021 cggactcggc cctggtcacc cacgcggggg cgccgcgttc ggtgttgcgt cccttgtgga
     7081 cgaaggcgat gttgtggtgc agagagatgc cggacaccgt gcggtcggtg agcgacgggt
     7141 cgtgctcgac gtcgcggacg agttgctggt ggttgagtcc gtcgatcagc tccttgacga
     7201 agccgaccgt cgtcgccggg gtgctcagtt cggtgctgct gccgccccag cccggccagt
     7261 acgacgcgcc gaggtcctcg atcacgtaca ggccgcccgc ccgcagatgc gggaacagga
     7321 tgcggaagga ggtcaggacg tggtcgttca cgtggctgcc gtcgtcgatg acgaggtcga
     7381 acgggccgtg ctcggcggcg acccgggcca ggaagtcgag gtcgtcctgg gcgccgaaca
     7441 ccgaccgggc gcgctgcggg gcggtcagcg ccttgtcctt ggcgtccatc cggatcactt
     7501 cgccgcgccg gaagtagtgc gtccacatgc gcatggactc gccgccgtcg cagccgatct
     7561 ccaggacccg cacgcggctg tcgcggaagc ggcggaagtg ctgctgatag tgcccggtgt
     7621 accagtgcct gccccatttg tcggttccgg tgcggatcgc cagctcggtc aggtcgacag
     7681 ggttctgcgt ggccgccagg gaggccgagc gggcggcggc cacggcggcg gcgcggcggc
     7741 gggccagccg gccggtcggg tccgagccgg gcgggccgtc cggggcgttg aggaagatct
     7801 ccctggtggc gtcgtggacg ccggcctcgc cgtacaccga gcggagcagt tcggtgagct
     7861 cctggcggat caccacgtcc ggctcggcga gcggaccggc cgcgacgctc gccgcgccgc
     7921 cgccgacggt cagcgtgtag gcgagccgtc cgccgccgaa gcccaggtcg aactgcaccg
     7981 gcaccttctc ctccgggccg ggcagcacgc cggtcagcgc ggccacctcg gccagcacga
     8041 tctcggcgac ctcggcgggg cccagggcgg ccacggcggc gtgcgcctcg tgctctggca
     8101 gcgccgcgac ggcgacgacg gatgcggatg tgacggtcac ggggtcatcc cttccggatt
     8161 cggggtgggg cctgccagca cgacgggcag gacgctgatg cggcgggtca tccactcgga
     8221 ctcccatccg acctcggtcc gctcgctgag cctggcgtgc gggaaacggc ggaagaacgc
     8281 ggtgagcgcg atccgggcct ccagacgggc cagcggcgcc ccgaggcagt agtggtggcc
     8341 gagtccgaag ctgatgtggc cccggcccgc ctcggggtcg aactcgccgg tgcgctcgtg
     8401 gtgcgggcag cggttggccg ccgccacgtt gatctgcacg ggcgcccccg cggggatcag
     8461 gtagccgccg aggttcacgt cctcggtggc gaaccgccag gtggcgtgcg ggaacggcgg
     8521 gtgcacgcgc agcgtctcct cgatccaccc gtcgatctgc tcgggggtgc gcggccgggc
     8581 gccggcgtcg cggccgagcg cctccaggat cccggcggag atgaggctcg ccgtggactc
     8641 gtagcccgcc atcaccaggc cgaccgtcca ggtcacgacc tcgtcggggg gtgatggcct
     8701 cctcgccgtc cacggcgtcg agcaggccgg tgatcagccc ctcggccagg gggcccgggt
     8761 cggcggccca gcccgccacc gcgccggcca gcgcgccgac gccgcccgct cgctcctcct
     8821 gcttcggcga gtagatgatg gcgtcggtgg cccgccgcat caccgcgtac atctcgggcc
     8881 gcaggccgag catctcgccg atgaaggcca gcggcagcgg gtaggcgtag cgctccatga
     8941 ggttcagctc gcccgacagc ccgtccagca gttcctccgc gagcgcggcc agccgggcgc
     9001 cccacctctc ggtgttgcgc ggtgtgaaga cacgcgcgtg caggcgccgg atgcgggcgt
     9061 gctcggggcc ctcgctcatc accatcgtgc gggcgacgtc ggcgcgcggc tgcgagccga
     9121 tcatgacacc ggtcacccgc cgcatccact cgggggtgag ctcgatgtcc ttgctgagcc
     9181 tgcggtcggt gaaggcggcg cgcgccagtt ccatgtcggt gaccgcccac gcggtgcccc
     9241 cgtagtagtc gaccttgacg accggcgcga cgcggcccgc cgcgaccagg ctcggcagga
     9301 cgtccacggg cgccggaatg gtcggcacgt ccacgtgcgg cgcgtccagc agctcttcgg
     9361 atctcacagc gggcctccgg tggcgggcgc ggtgcgggcg gggatcagtt cctcgatcag
     9421 ctcggcggcc cggcgcgggc cgtcgtgccg ggcgaaggcg tcgtgcagcc gggccgcggc
     9481 ggcccggtgc tccgggccgt ccagcaccgc ccgtacggcg gcgcgcaccc gctccggggc
     9541 gagccgcgcc ccccgcagcg ccaccccggc acccgcgtac gccacccggg cggccacgtc
     9601 cgccttctcc tccgtggccc cggcgacgac cagcgggacg ccgtgcctga gcgccgccgt
     9661 gacgccgttg aagccgccgt tggtgaccat gacgtccacg tacggcagca gccggtggta
     9721 cggcacgaag ccctccaccc gcacgttcgc gggcagcgtc ccggcgctcg ggccgagcgt
     9781 gcggttgccg gtggtcacga cgaccagcac cggttcgtcg gcgagcgccc ggatcgcggg
     9841 caggagcagc cggcgcgcgt cgtcggcgat cgtgccctgg gtgaccagca cgaccggccg
     9901 ctcgccgcgc agctcctccc accacggcgg cgggtcgaag gccgtgtccg acggcggcag
     9961 gtcgagcgcg ccgacgaagt gcgtgcccgc gaacaggtcg gagcgcggga actccagctc
    10021 ggcgacggtg cccacaagat agcggtcggg acggcgggcg atgttctcca tcccgcccgc
    10081 gcgcaggcgg gccagccccg cctgcgcgcg ggccgcgtcg gccgcccgcc gcagcccgcg
    10141 cagcatgatg tgatcgcccg cccaggcgag cacggcgttg cgcaaccggc ccgcccgcgt
    10201 cgccgagggg ccgaggccgc gcccgagcgg agcggtgtcg cggctgccca gcacgtagat
    10261 cgagttgccg atccacacgt gcggcagccc ggtgtgctcg gcggcgaagc tcgcgccgta
    10321 gcacatgtcg tcggacacca gcacgtccgc ggggaaccgg tccagcaccc ggagcaggtc
    10381 gtccatctgg tccggcgcgg tgcggtagaa gatgtcccgc atccccgcga cgaaactcgc
    10441 cgcgccggtg agccgggcct gggcggggaa cgcctcggcc ttgctctgcc cggagaagtc
    10501 gtgcgccgcg aacatcggca gatgccgcgc gccgacggcg gtgatcttgc tccggtagcc
    10561 gtctccggtg taccagcgca cgtcgtggcc ggcgcgcacc aggttccgcg cgaccgggac
    10621 caccgggttg acgtggccgt cagccggggt cgtcgcgatc agaacgtgtg ccaaggccgc
    10681 cctccctcgt cagtacggcg gcaccgccct gccggcctgc cgcgctgacc cgaccgtcgc
    10741 ccccggcgct ccggcccggc aagagacccc cacagacact gccagtcctg gtgatttccc
    10801 cgcactccac gcgatcccgg tacgtaaacc gctactcact ctggggacac cggctgggga
    10861 tgtgggtccg ccccggcccg ccgacgatgg ggctcacctg cggttcgaca caccgtcgaa
    10921 agggaggaac acccctatgt tcagtcgtct accgaatgtg cgggagcccc ggcgggtcac
    10981 cgtactgggc gcgggcgtgg cggggctggt cgccgcctac gagctggaac ggctcgggca
    11041 tcaggtggag atcatcgagg cggccgaccg ggtcggcggc cgtgttcaca cgcaccggtt
    11101 cggttcggcc cccggcgccc cgttcgccga cctgggcgcg atgcggctgc gcaccgacca
    11161 cacgcgtacc ctgcactacg tcgtcgagct gggcctgcac aacgacatcc gcgagttccg
    11221 cacgctgttc gccgacgacg gcaacctgct gtcgatccac gacgagcggc acatcagggt
    11281 gcgcgaggcc ccggacgtgc tcaccggcag gctcgcggca cggctcggcg accactccta
    11341 ccggccggcc acgctgctgt tcggggcgtg gctgcacgcg tgcctggagg ccatcgcgcc
    11401 ccgggacttc aacgactggc cggaggtcac caccgaactg ctcgatctgg tcgacggcat
    11461 cgacctggag ccgtacctgc accccgccgg gtccaaaccg gacctgtacg ccgtggtgaa
    11521 ggaccacccg cagatccgct caggaccctt cagaggccgc gagcggctgc tggacgacgt
    11581 cctggacgag accagccccg cgctctaccg gctgcgcggc ggcatggaga cgctcacgaa
    11641 cgcgctggcc gcgcgcatcc agggccccat ctggctgaac caggaggtga ccgggatcgc
    11701 ggtgcacgac gacggcgtgg cggtcggcgt ccggcgcggc ggccggatcc gctaccggaa
    11761 ctacgaccac gtactgtgca ccatcccgtt caccgtgctg cgcggcctgc ggctcgacgg
    11821 gttcgacgcg gacaagctcg ccgccgtcca cgagacccag tactggccgg cgaccaagat
    11881 cgcgctgcgc tgccgcgagc cgttctgggc cgccgacggc atcgccggcg gcgcctcgtt
    11941 caccggcggg ctggtccgcc agacctacta cccgcccgtc gagggcgacc cggcgcaggg
    12001 cgcggtgctg atcgccagct acaccatcgg cccggacgcc gaggcgctgg gcaggctcga
    12061 cccggccgcc cgccgacagg tggtcctgga cgaggtcgcc cggatgcacc ccggcctgcg
    12121 ggagcgcggc atgatcctcg acaccgccgg ccgcgcgtgg ggcgaacacc ggtggagcct
    12181 gggcgcggcc accatccgct ggggccagga cgccggcacc cgcaaggagc agcagtgggc
    12241 ggcggcccgg ccgcagggca ggctgttctt cgcgggcgag cactgctcgt ccatgccggc
    12301 ctggatcgag ggcgcgatcg agtcggtcac cgacgcgctg cgcgacatgg agacccgcga
    12361 cccgcacgaa ctgatgcggc tggatctggg ccgatgagcg tcttcagcct gccccgcctg
    12421 cacttcgccg gcctggcgac gacccagttg cccaccggcc cgaggcaggg gctcaccgac
    12481 ctcgccacga acggggcgct gtgcgcggac ggcacgccgt tcccgcccgg ccgtcccccg
    12541 gccgagtacg acgggccgcg cggcgagcac ttcgcgggca acggccactt cgccgtgccg
    12601 tccgccgcga tcaccggcgt cgaactgcgc gcgggcgagg tggacacggc cgatccggtg
    12661 gtgggccgcc aggtcgatct gtgggggcac tacaacgagt acctgcagac gaccgtgaac
    12721 cggggccgtg tgttcgacgt cgacccggcc tcgaactgga ccaccaccgt gatggtgggc
    12781 cagttcgggt tcgggcgggc ggggcgctcg cacgacaccg ggtacgcgct cgtcggcgat
    12841 gtgcacggct accagccgcc gaggtggcag gacctgcgca ggggcacggt cgtgcaccag
    12901 ttcgcggtgg cccgcgagga gatcgcctgg ccggcgccgg tcgccgggtc cgaggcggtc
    12961 gccgcgctgg cgcgggcgct ggccgggtcc gacgggctgg tcgtgcagtt cgccctgctc
    13021 gccccggacg gcccgcgcct gccggacgcg ccgaggagct gggaactgcg cggcacgatc
    13081 gcgccctggt ggcgcgccga gcccaggacc tttcccgccg ggcggctgat gctgccggtc
    13141 gagccgggcg tccgggtgtt ctccgtggac gtcggtgccg agtacgtcac gctgaacctg
    13201 gtcaccgccg ccgcgtcgct gccgcccggc gaggtggaac tgcggaccgc gcggaccggc
    13261 aagctggtcg ccgccgtacc cgtgcggtcc tgccgggagt ccgcgcggca cggcgggctc
    13321 gtctgcgcga cccgcctggg cgaggcggag gacgaggcgc tggtcctggt cgccgcgcgc
    13381 gacgggcggg tgctcgcccg cgagcaggag gtcgtactgc aggccgacga cgcctgccag
    13441 gtgctcgacc accccaggca cgcgggcgac gactcgtgcg acgccgaggt ggggttccgg
    13501 tcgttcgtac gcggccgccc ggcgcccgtg gcggtcgtgc gggtgcggca gttccccaac
    13561 ccgagggcgc tgcccctcgc ccccgacgcc gccaccgccg agatcgtgca cgtcgccgac
    13621 cccgagagaa ccggccccga gagcaccgac actctgagca ccgacactct gagcaccgac
    13681 actctgagca ccgacactct gagcatcgac cccccgagca tcgacactgt gagcaccgac
    13741 gccggcggct tcggccgact cacgttgcgc gggctgcggc ccgggtccac gcgcctgctg
    13801 ctgggcggcg acgccacggg agtccactac gacaacgacg acgagctggg gttctgggcg
    13861 ggcgccggcg gcgtgcacgt gcgggtgctg cccgacgact ggcggctggc ggacctgcgc
    13921 gacgacgagg tgaccttcga gaccgtctac cgcgaggtct tcgccccgta cgaggcccag
    13981 tactcgttca tgcgcgagga ggtcttcagc ctcgccgacc gctgcaaggt cgagacgtac
    14041 gccaagctcg tctggcagat gtgcgacccg cgcaacaagg cgacgacgta ctacatgccg
    14101 cccacccgcg acctcaccgc gccgaaggcc gcgctgctgc tcaggtacct gcggcgggtg
    14161 cagcggccgg accacgtcct gctgcgggcc gagacgcccg ccgcgcggcc cggcctcgcg
    14221 acccgggccg aactcgtcgc cgcgctgcgc gacgcggtga agctcgaact ggccgtgatg
    14281 atccagtacc tgtacgcggc ctacaccgtg cccgaccacg gcgccggccg cgagtacgtg
    14341 cgccggggcg actggacgcc cgagcagctc gcgctcgcct gcggcgacgg cggcgagacg
    14401 ctcgcgggcg gcatcagggg cacgctgatc cgggtggccc gcgaggagat gatccacttc
    14461 ctgctggcca acaacatcct gatggcgatc ggcgagccgt tccacctccc gcacctggac
    14521 ttcggcacgc tcaacgccga actcccgatc gcgctcgact tctcactgga acgcctggac
    14581 gtcgccagcg tcgcccggtt cgtccgcatc gaggagccgg acggcctggt cacaccggta
    14641 cggctcggca cccgcaccag caccggcacc agcaccagcg ccgacgccga cgccgacgcc
    14701 gacggcgacg gcggagaacc cggctacgcg tcgatcagtg agctgtacgg cgacatccga
    14761 cgggcgctca ccacgatccc cggcctgttc ctcaccgagc ccggccgagg cggcggcgag
    14821 caccatctgt tcctgcgcaa acgggtgaac gaccaccatc cggactacca gcttgaggtc
    14881 gacgacctcg ccagtgcgct gttcgccatc gacgtgatca ccgagcaggg cgaaggcggg
    14941 gaactgaccg acggggacga gccgtcggag gagtcgcacc acgccgcgtt cctgggagtg
    15001 gccgaggcgc tgcgccggtc ggactgggtc ccgtcctacc cggcggcacg caacccgacg
    15061 ctgcggcggg gggatcgcgc ccgccaatac ataccggacc cggacgcgcg ccgggtgatg
    15121 cggctgttca acgccgccta cgcggtggcg ttgcagctca tggtgcagca cttcggcgcg
    15181 ggcccggaca ccagcctgcg ccgctcgaag ctcatgaacg ccgccatcga cgtgatgacc
    15241 ggggtgctgc gcccgctggg cgagctgctg acgaccatgc cgtccgggct gcgcggccgt
    15301 acggcggggc cgtccttcga gctcgacgcg ccgcccgcct tcatcgcgcg ccccgacgtg
    15361 gcggcgctgc gcgtcgcgcg gcagctcgac gacgtggcgg cggcggcctc ggcctgcccg
    15421 ccggtgcccg cacgcgtggc cgagatcagc accctattgg ccgaacagtt gaggggaagc
    15481 gtgagatgac tcgcagcgaa gagaccgacg tcctcatcgt gggcggcggc cccgtgggcc
    15541 tggccctgtc actggacctc acccatcgcg gcgtccggca catcgtgatc gacgcgggcg
    15601 acggcgtggt gcgccacccg aaggtcagca cggtcgggcc gcgctcgatg gagcacttcc
    15661 gccgctgggg ggtggccggg cgggtcaggg acgcgggctg gccgcccggt cacccgctcg
    15721 acatcgcgtg ggtgacccgc gtcggcgagt acgagatcca ccggttcgag cgcggcaccg
    15781 ccgccgcccg cccggtgttc cgccacacgc cggagccgga ccaggtgtgc ccggcccacc
    15841 tgctgaaccc ggtgctggcg ggcgcggtgg gcaggccgct gcgctacctg caccgcctgg
    15901 agcacttcga gcaggacgcc ggttgcgtgc gggccacgat ctcctcgaac ggcgaggaat
    15961 cggtcgtctg ggcgcgctat ctggtggcct gcgacggcag ctcctccgtc gtgcgcaagg
    16021 ccctcggcat cgactcgccc gcccgccacg aggcgcaggt cttccgcaac gtgctcttcc
    16081 gcgcgccggg gctgcccgcg cgcctcgcgg agcgcggcca ccggagcgcg ctggtgtact
    16141 acctgatgca ctcctggtcg ctgcgctacc cgatgcgttc cctggacggg cgcggcctct
    16201 acaacatggt cgtggacggc cgctccgacc agggcgcgct ggagctgatc cgctccgcca
    16261 tcgccttcga cgtgccggtc gagctggtcg ccgacggcct gtggcacctg acccaccggg
    16321 tggccgaccg gtaccgggcg ggccgggtgt tcctggcggg cgacgcggcg cacacgctgt
    16381 cgccgtccgg cgggttcggc atgaacaccg gcatcggcga cgccgccgac ctgggctgga
    16441 agctcgccgc cgccgtcgcg ggctgggcgg gcgacggcct gctcggcacc tacgagaccg
    16501 aacgccgccc ggtggcgatc gccggcctcg acgcggccga ggcgaacctg cggcgtacgg
    16561 tcgaccgcga cctccccgcc gagctggccg cgtccacgga gaagggcgcg cggctgcggg
    16621 cggagatggc cgagcggctg gtgaacagcg gcgcgcgcga ggagttcgac gccccccgcg
    16681 tccatttcgg gttccactac cgctcgccga tcgtggtctc cgacgggccg gccgagcagg
    16741 gcccgaggtg gcggccgggc agcgacccgg gctgccgcgc cgcccacgcg tgggtacgcc
    16801 cgggggtgtc cacgctggac ctgttcgggg acggcttcac gctgctgcgc ttcgccgatt
    16861 cgcccgcact gtccgcgttc gttacggcct tcaccgagcg cggcgtgccg ttccggtcgg
    16921 tgctcgtggg cgacccggac accgccgccc tgtacggtca ccgtttcgtc ctggtccgcc
    16981 ccgacgggca cgtggcctgg cgcggagacg acctggaggc ggctcccgcg aacctggcgg
    17041 atctcgtgcg aggggcgggg tgatggagcc gttctccccg ctgggctggt ccccggccga
    17101 tctcgccgac ccgtacccga tctaccgccg ctaccgcgag gccgacccgg tgcaccgcgc
    17161 cggtcccggg acctggttcg tgttcgacca cgagcatgtc gcgcagaccc tgtcgcgccg
    17221 tgacttcggc cgtaaccggc ccgcgcacct gccgggccgc aacgacgcgc tgtatcgcag
    17281 cgtgcgggac tggctggtgt tcctggaccc gcccaggcac acccggctgc gccgcctgct
    17341 ggccgccgag ttctccccga aggtcgtggc ggggttgcgg ccgcgcatcg cctcgatcgt
    17401 cgcgtcgctg ctgcgtccgc tgtgggggcg ggaggagttc gacctggtgc gggagttcgc
    17461 cgcgccgctg cctgtgctgg tgatcacgaa ggtcccccgc ttggcgaatc ccttcgtctc
    17521 gtcgaggaca ccgtacgccc gcgcgacctg tccgtgtggc cagaagtctg acagcaacgg
    17581 gaatgtataa ccctcttggt cggcccatgc ccggtgggtg aacacggagt ccgccgacac
    17641 ggtgaggatc tgccaggcgc cccgggcggg gcagttctgc gaggactgcg ggcacgacta
    17701 ctcaggcagc gcgccgctcc cgccagccgg gctcgtcccc gcccgctggg aggccgtggc
    17761 gggcgccgac cgcgcccact tcgaccgggt cgtcgccgaa ggcgggccgg acgcggccgg
    17821 gctggtgttc ccgccgtact gtcccgagcg ctcgttcgcg ctgtccggcg accaggtgcg
    17881 catcggcagg cacagccgta cacgcgacag cgcccccgag atcgacctga gcggaccgcc
    17941 gcaggatccg ggggtctccc acctgcacgc ggtgctcctg gcgcgggccg acggcggctg
    18001 gaatctcgtc gatccgggct cggccaacgg caccctcgtc aacgaccggg tggtcaaggt
    18061 caacgtgccg gtggccgtac gggcagggga ccggatccac gtcggcgcct ggaccgtgat
    18121 caccctccgg gagagcctgc catgaccgtg gtccagcagc accccgccgc ttcccccacg
    18181 cgggtgaacg tgccccggcg cctcacccgc atgaccggcc tcacgctggc gtcgctgctc
    18241 gtgctgttcg ggctcgtcgg cgccgccggg ctggtcgcgg gcgacggcat gcgcgtcgtc
    18301 ggccgcgacg ccggccccca ggtcctcgcg accgccggcc tctaccacgg gctcagcgac
    18361 atggacgccc aggtcgccga cgtcctgctc atgggcaggg agtacggcga ccgccgcgcc
    18421 gccgcgctgg cccgttacga gcagcgccgc gccgaggcca accaggcact gctgaaggcg
    18481 ttcgagctca ccggggacga cccggcggag cgggtgacca tccagtccgt gctcgacggc
    18541 ctcggccgct acgagtggct ggcgggccgg gccatgctgc tcgacaccca ggccgcgcac
    18601 gcggcggggc cgcctccgga gacggtgctc aaggtctacc ggcaggccac cgacctgatg
    18661 cggctggagc tgatgccgaa ggcgtacaac ctgacgctgg agagcggcac catcgtgcgc
    18721 cgcacccacg acgagaccgg gttcaccgta cggctgctgc gcgacggggt gctcgccgcg
    18781 ggcgggctcg cgctcgtcgt gctcgcggcg ctccaggtga cgctgtcccg gcgcttccgc
    18841 aggacgctgt cgccgccgct gctgaccgcc accgccctca cgctcgccct cctgatcgcc
    18901 ggggtgtcgg cgctggccgg ccactcggcc gccatggacg aggccaagca gggcgggttc
    18961 gacgccatgc tcaccctgtc gcgggcgcgg gccgtcgccg gcagcctgca cgccgaccag
    19021 gccagatacc tcctcgaccc ggaccgggcc gacacctacg agcacgcctt cctggacaag
    19081 tcgcagtccc tcgtctacac cgagggcggc aacgtcgagg cgtaccacgc cacgctcgcg
    19141 cgggccaagg gtcccgtccg gctcggcatg ctgcgcggcc gggccgagat catgaagagc
    19201 taccggcgac tgcacgccac cgacgggcgg atgcgcgccg agcacacctc cggtcgccgc
    19261 gcggccgccg tcgccaccaa gctcgggccg ctggccgagg actacgccgc cctcgacacc
    19321 gtcctcgccc agcgtggcac cgcccaccgg gcgaccttcg accgggcggt ggcctcgggc
    19381 gacgaggcca tggccgggct gtggcggctg gcgcccttcg ggatggcggc gatcgtggcc
    19441 ctggtcgtca tcggagtctg gccacggctg agggagtacc gatgagacgg ctgccgatcg
    19501 cggcgctgac cccgctcacc ctgctggccc tgctcgggct gctggcggga tgcggtgcca
    19561 cgggcgacgg cgtcttgtcc gccgacaccg tccgggtcgc ggtccgggtg gacctgcccg
    19621 gcatcggcgc gcgcgggccc tccggcgccg tcgagggctt cgacgtggac gtggcccgct
    19681 acctcgtcgg caagctcggc aagaaggcgg tcttcgtgcc ggtcaccgcg gccgaccgcg
    19741 agaaggtcct cacctcgggg cgggccgaca tggtgctggc cacgttctcg atcacgcagg
    19801 accgcaagga gcgggtgctg ttcgccgggc cgtaccagct atcgtatcag gacatcctgg
    19861 tacgccgggg ggagacccgg atcaagaacg tgcgcgacct ggccgggcgc agcatctgcg
    19921 aggtgaaggg ctccaacgcc gggcagcggg tcgtcgagga gcgcaaggtg gcggcgcggc
    19981 tggtgccgtt cgacagctac gggccgtgca tggagcggct gctgtcgggc gaggtggacg
    20041 cggtcaccac caacgacgtc atcctcgccg ggctcgctgc ggagagttcc gggctgcggc
    20101 tggtgaacgc gcagttcaac gagcagcgca cgggcgtcgg gatgcggctc ggggacgtgg
    20161 agggctgcga ggccgtcaac cgggcgatca ccggcatgta ccaggacggc acggccaaga
    20221 agctgctgaa gaagtggttc ggcaagaccg acctgcccat ctcgacggtg tcggtcccgc
    20281 agttcgaagg ctgttcctga
//
