LOCUS       BGC0000816             20179 bp    DNA     linear   PLN 22-DEC-2012
DEFINITION  Malbranchea aurantiaca strain RRC1813 malbrancheamide biosynthetic
            gene cluster, partial sequence.
ACCESSION   BGC0000816
VERSION     BGC0000816
KEYWORDS    .
SOURCE      Malbranchea aurantiaca
  ORGANISM  Malbranchea aurantiaca
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Onygenales; Malbrancheaceae;
            Malbranchea.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 14:15:37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 20179
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(<1..>2004)
                     /gene="malA"
     mRNA            complement(<1..>2004)
                     /gene="malA"
                     /product="flavin-dependent halogenase"
     CDS             complement(1..2004)
                     /codon_start=1
                     /gene="malA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119:halogenase (Score: 142.6; E-value: 3.3e-43)"
                     /gene_kind="biosynthetic-additional"
                     /note="MalA"
                     /product="flavin-dependent halogenase"
                     /protein_id="AGA37261.1"
                     /sec_met_domain="Trp_halogenase (E-value: 3.1e-10,
                     bitscore: 28.3, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPTPKYTFTERAAAGNLSDAEILNSNNPTGSELPDESDVVVGGA
                     GIHGLIYALHASKYKPNNLKISVIEKNTRPGYKIGESTLPIFYTWCKLHGISAAYLLRL
                     FGLKDGLCFYFLDRENQGQYTDFCSVGAPGLVLASLQIERPMSELLFTILAQRNGVNVY
                     HGREVDFKSTVVQGGGQGNKIAVSRGKYDSTPKTIDSALFVDATGRFRQFCSKKAPRHR
                     FDGWNCNAFWGYFTAPKDESKIPFDLYEGDHTNHLCFPEGWVWVIRLPSWEGSLIANLM
                     DMVTYILECADAGVPGDELPSSEELARMFGLKFQWVTSIGFAVRNDVKYPEDLSAYGTR
                     EAEQKFNYFVQKYELLQQFMSNFELIENLYGPGTTWFIRKTLAYQSPVVSGPGWLAIGD
                     ACGFTNPLYSPGINVGMSTSTWAAQLSHRIVEIGKSAPADAAESSIRKLLVPYDDYCKS
                     LVPALEQMNRFNYVCYRDTRLGPQVACLWQFFAGIERYLSDVNIETFAHYAIKWVWGAM
                     VPEYQQVAQKCIEHIETVPLDERLPDAMVDELLAFSNRIKSAAVAADDFSLRWDAILRS
                     FDRSLNFVEGKTSRDIYTRQCSGCGAWLQLRPDWKKCHSCGLLGTEPQTAVTFDPPLTA
                     EEEALLYAAWNTAPKYDPSKELKLPTPTRPAA"
     source          1..20179
                     /db_xref="taxon:78605"
                     /mol_type="genomic DNA"
                     /organism="Malbranchea aurantiaca"
                     /strain="RRC1813"
     misc_feature    <1..>20179
                     /note="malbrancheamide biosynthetic gene cluster"
     protocluster    1..20179
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[13141:20179]"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      13142..20179
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     cand_cluster    1..20179
                     /SMILES="N1C(CCC1)C(=O)NC(CC1=CNc2c1cccc2)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX))"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="indole"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..20179
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000816"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..20179
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="NRPS"
                     /product="indole"
                     /region_number="1"
                     /rules="cds(Condensation and (AMP-binding or A-OX))"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /subregion_numbers="1"
                     /tool="antismash"
     protocluster    1..19459
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[3053:9459]"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      3054..9459
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="2"
     cand_cluster    1..19459
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="2"
                     /tool="antismash"
     gene            <3054..>4163
                     /gene="malB"
     mRNA            <3054..>4163
                     /gene="malB"
                     /product="prenyltransferase"
     CDS             3054..4163
                     /codon_start=1
                     /gene="malB"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /note="MalB"
                     /product="prenyltransferase"
                     /protein_id="AGA37262.1"
                     /sec_met_domain="dmat (E-value: 2.1e-89, bitscore: 289.3,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPSQSPYHALSRYFSFPNRDHQAWWTGKGPLLGNMLADAGYPEQQ
                     QYQYLTLFNLHLIPALGPSESHGAGIDGAEWKSLLSGSGKLEFSMTYRKSAVSLRIAFE
                     PTSLLAGTKKDVFNKRRTQQLLGDLERLDIDIDTVLYHPLFDTLVVSDEEEAALQNAGT
                     VIPDSSRTQQLLALNLIEGNVRADLYVYPYVKALATGTASSTLLWAAVKKIDRYNRFRD
                     ALSILKGYFETYPSSTTNPMFLSSDLAAPRNAFCRLFFSETNFSWERVQHLWTLGGTLS
                     DKPTLKGLELAKILWDILGISTAPASPDSFPLLFTFELRPEQPYLRQKLGIPVSGLTES
                     AIANACVAFFERLGWDDHAASYRTNLSAY"
     gene            <4886..>5680
                     /gene="malC"
     mRNA            <4886..>5680
                     /gene="malC"
                     /product="short chain dehydrogenase"
     CDS             4886..5680
                     /codon_start=1
                     /gene="malC"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     100.6; E-value: 1.7e-30)"
                     /gene_kind="biosynthetic-additional"
                     /note="MalC"
                     /product="short chain dehydrogenase"
                     /protein_id="AGA37263.1"
                     /transl_table=11
                     /translation="MAPTRRSRDLLRGKNVLIIGGTSGIGFAVAQLVIEHGAMACIAGS
                     NPTKLGKALDALKQHPDRDPIAIVQSATCDLFDVPNLEQNLDNLLKLAAGDSKIHHIVF
                     TAADMVQPPPLASVTIEQIQRVGTIRFTAPMLVAKLLPKYMELCPENSYTLTSGSHAKQ
                     PDPGWSLVTGYCGGVEGLMRGLAVDMMPLRVNVVSPGAVLTPVLRDILGDSLEIALDAA
                     RKKSTTGRIARPEDVAEAYLYIMKDQNITGTVLETSAGMLLR"
     gene            complement(<5937..>7270)
                     /gene="malD"
     mRNA            complement(join(<5937..6202,6299..6628,6707..6860,
                     6932..7149,7228..>7270))
                     /gene="malD"
                     /product="negative regulator"
     CDS             complement(join(5937..6202,6299..6628,6707..6860,
                     6932..7149,7228..7270))
                     /codon_start=1
                     /gene="malD"
                     /gene_functions="other (smcogs) SMCOG1199:NmrA family
                     protein (Score: 82.5; E-value: 6.1e-25)"
                     /gene_kind="other"
                     /note="MalD"
                     /product="negative regulator"
                     /protein_id="AGA37264.1"
                     /transl_table=11
                     /translation="MDTGKRLVTVFGGTGNQGSSVVRSLLAHKDKLFHVRVITRDPTSE
                     KAQACAKLGAELVKADGFNKSETVSAFMGSWGAFVNTNSDEEIYKIPGGRSDYDLGSTV
                     LDATKEAGVKHVVYSSGLNLCKYTNGRVHSEGFESKYYVEQYGRRKGFQTFTPIVPASF
                     MEAFLAESFCQSLGGFPWFKRDTGEYLLATPPYGGDERMPWVSVEDDFGDIVHGIFLDP
                     DSYHLKTIQGSSELISFEKMVEDFMEVTGEKARYVRLKSWVDIPLDGTSCREEMRAIFH
                     SMYSNGGKWFVPDESEIDTATTLKKEAKLAQGVTDGSLTAFKDWIHKQWERRLPN"
     gene            <8047..>9459
                     /gene="malE"
     mRNA            join(<8047..9200,9297..>9459)
                     /gene="malE"
                     /product="prenyltransferase"
     CDS             join(8047..9200,9297..9459)
                     /codon_start=1
                     /gene="malE"
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     dmat"
                     /gene_kind="biosynthetic"
                     /note="MalE"
                     /product="prenyltransferase"
                     /protein_id="AGA37265.1"
                     /sec_met_domain="dmat (E-value: 6e-128, bitscore: 416.3,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGPMGNKSTSDIDSVLVYKSLSRYLKFSENEEGWWHKTAPLLN
                     KILAAAKYDVHLQYRYLVFYYAACVSALGPYPQRFSSSITRSGLPVEFSVNYQNNSKPI
                     VRIGYEPISHLSGTERDPYNHKTASEIVATLSKIQPDFDPRLFNYFVHQLSVNKAESDV
                     LNGANVEGSEMKSQTAFGFDLVNGEISVKGYAFPAMKCQVSQQSLSQLLKAAINGLKGE
                     FDCAFGLVDEYMERCGGYNQFSFVSWDCVVPAKSRFKVYGVHNDVTWKKIEDIWTLGGQ
                     ATSGNVTKGLELLKELWTLIDLDEGERGYTGRFDDANDNGSNIQSPMVWNYELRPNNPW
                     PLAKFYFPVHGENDMKIVKGLARFFENRGWTELARSYVQTVSSFFPDRDLNQTQRLVSW
                     ISFAYTEKTGVYLSVYYHSSADYLWISESGEKRGQGDGA"
     gene            complement(<10457..>12368)
                     /gene="malF"
     mRNA            complement(join(<10457..11437,11521..12047,12104..>12368))
                     /gene="malF"
                     /product="oxidoreductase"
     CDS             complement(join(10457..11437,11521..12047,12104..12368))
                     /codon_start=1
                     /gene="malF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 289.5;
                     E-value: 1.1e-87)"
                     /gene_kind="biosynthetic-additional"
                     /note="MalF"
                     /product="oxidoreductase"
                     /protein_id="AGA37266.1"
                     /transl_table=11
                     /translation="MKYTATFALLILAIGIQTQRRSTICRCRQEDACWPTTAEWSSLNQ
                     SIDGKLRHLRPVGLPCQQSAYHKEKCDEVLAMTHNSSWRVDHPESLQLVSWESWPEKNQ
                     SCQIVREAVDGCAQGRIPLYSAAVESTKQVQQAVSFAKHRNLRLVVRNTGHDMAGRSSA
                     PGSLQILTSGLKGINYTENFVPFITQGSAEPMGPAVTIGAGILTGELYATGSEKGFVVL
                     GGACSTVGIAGGFIQSGGMGILSPSKGLGSDHVLQVEIVTADGSHIIANQYQNEDLFWA
                     VRGGGGGTFGVITSVTLRAFADLPATVTGIQINTPSADAIFWAGVKTVLSILPELTDAG
                     NSARMIVLPASSTGGASASFEGYTFNKKGAVSLLALQRALDDFGIPFKLSHDFQGNLSR
                     FLAAPKGVDLAGISVIPGSVFLSYDLVASKDGPAKVTSALSDLRLGPGSSFSVDAFGGG
                     QVVNNKNRINSAVHPDWRSALLSLTVGRGVPPGYTLETLKSIESELENDQLPRLRSLEG
                     GRKGAYLAVAYPNEVYFQDSFWGKNYDRLLKVKRAWDPEDLFITRVGVGSERWDDEGMC
                     TRADSGLWHALARF"
     gene            <13142..>20179
                     /gene="malG"
     mRNA            <13142..>20179
                     /gene="malG"
                     /product="NRPS"
     CDS             13142..20179
                     /NRPS_PKS="Domain: AMP-binding (225-621). E-value: 6.6e-83.
                     Score: 270.4. Matches aSDomain:
                     nrpspksdomains_malG_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (768-833). E-value: 4e-13. Score:
                     41.3. Matches aSDomain: nrpspksdomains_malG_PCP.1"
                     /NRPS_PKS="Domain: Condensation_DCL (876-1149). E-value:
                     3.4e-34. Score: 110.2. Matches aSDomain:
                     nrpspksdomains_malG_Condensation_DCL.1"
                     /NRPS_PKS="Domain: AMP-binding (1316-1707). E-value:
                     3.5e-77. Score: 251.5. Matches aSDomain:
                     nrpspksdomains_malG_AMP-binding.2"
                     /NRPS_PKS="Domain: PP-binding (1854-1922). E-value:
                     3.3e-10. Score: 32.3. Matches aSDomain:
                     nrpspksdomains_malG_PP-binding.1"
                     /NRPS_PKS="Domain: TD (1971-2213). E-value: 2.8e-40. Score:
                     129.9. Matches aSDomain: nrpspksdomains_malG_TD.1"
                     /codon_start=1
                     /gene="malG"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127:condensation domain-containing protein (Score:
                     106.1; E-value: 4.1e-32)"
                     /gene_kind="biosynthetic"
                     /note="MalG"
                     /product="NRPS"
                     /protein_id="AGA37267.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-91, bitscore:
                     296.3, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="Condensation (E-value: 8.6e-33, bitscore:
                     102.5, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 4.1e-11, bitscore:
                     32.3, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 4.4e-41, bitscore:
                     129.5, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDDPLLSSPTEAICLNHSVTDLRLAAALKLSWTFLLAHYSGSSE
                     IPLDIRLEYRYIDGSETNFEPFDATFEVDKKSLIEDSIGMIQNMLTPSTRPHSLSNGIN
                     SSQSDKHVPEAQVSFTFSSGSRPVLEKGATTRYAATVLELECLQGLKKEYLCRINFNRM
                     MWNVEEATGILRQFRHIAQQIVSADVCATLSQINLMCESDIEQLKRWNSTVPDPVLACI
                     HELFSEQAKKNPTATAVQTSEGSFDYGRLDELSSALACHLSSNGLTRGTPVPLLFDKSM
                     WMVVATLAVLKAGATCVSICTGLPTKAIEDILEQTAAQLVLVSESQGLRLSETRTQVVS
                     DKTMQIWHTMSGKPELPQSDPTDLACIIFTSGSTGKPKGIMLDHIALVTSIRNHGPSLG
                     ISSSSRALQFSSYAFDMSFYETYTTLLSGGCICIPSETERLNSLPQFICDHNVNWAFLT
                     PSVLRDFHPSEFPSLRTLATGGEPVGADIANEWAGRLQLFNLWGPAEATICATGPILPG
                     VWIPGTFGKAVGCIAWITQAENPDELVPIGAVGEVLIEGPVLAQGYSGDVEKTKASFIP
                     FPKWRERFELTPRGRVLFRTGDLAQYNPDGTIRYVGRMGTVVKVGGQRVDIDAVEYALR
                     RIDRSSHIAVEAVELEKETGQGPTLIAFLSSDMNGVSGSEKKRCCSIDPGSRSWEAWAN
                     IAIRLQDTLAGVLPRYMIPHLFIPVSTIPTTPSGKANKRQLQALVLGQSKAHLLQLCRQ
                     RSPDASYPEQHLTENETLLRLLVSDVLGIDRDHVAMNSRFFHLGGDSLAAVKLVALARQ
                     QGIQLKVEAILQSCSLREAAGTMISAGEKQKLQSKTSFAINKCDDKLGLLEEATVQCGI
                     SESDIEEIYPSTPLQEGLITVTSTFSASKPYVDKILFTLSATADLDRVRDAWNHVVAAN
                     DILRSRIILSPAGKAFNVVVRSEPSWQYYKTVQQYLENDNAQDMTFGKELITFNLIASH
                     DQSASARSIGITIHHALYDNWTVSLLHKQAEDAYRGELVEPCSFSTFSHYVLQQSPDIN
                     KEFWRKQFLDLRAGTFPELPSSDYVPRANSSSQHLYKGQHQRRDFSMATNIQLAWALLL
                     SLYTNSPDVVYGLVVNGRMAPMPGVGGLVGPTIATVPFRTTVERSMSVQAALEAIQKRV
                     LSIVPFEQTGLQNIARMGEGPKTACNFQNLLVIQQDLEFKGEGIFCRRQNLVGAVNNFP
                     GYGIILLCSATEHGWAFEILYSNSLIPETRARRILLQLDHLLRQLEVDPYRQLAQLELL
                     CPSDKSKLTSWNTQLPIRVNACIPEVFGAQCLVRSERTAVSAWDGSLSYRELDRFSSIV
                     ARHLQAVGVGKGTITPILFEKSRWVVVAMLAVLKTGAAFVMLDTNQPLQRKQGICRAVR
                     ATTIATSASCAHESKVLANSIYVLDEASITKTDTNQFLPLVEVSPNDLAYVVFTSGSTG
                     EPKGVLIEHASSCSASRAQAAKLGISPDSRVLQLSSYTFDSFAVEILASLLAGCCICIP
                     SESESSNDIAGAVRRFSATWLCITPSVLGLTNPDEVPSLKTVVAVGESARPSQIRLWST
                     RVNFICGYGPSECSTGASAQLIRSAGSDPRIIGSGMGSCLWVAHTDDHNVLVPIGAIGE
                     LLIQGPIVGRGYMNSPEKTRAAFLESTAWIPEFRQVATERFYKTGDLVRQNEDGSIVYL
                     GRKNREVKLRGQRLDLEEVENQLSAALEMDINIVAEVVKPKGVDSQPVLIAFFQVVADV
                     ELRSDNITFLELNPDIGLRLLDAEEKLRKILPPVMIPSVYLQVQRMPLTMSGKMNRQAL
                     RNKASTRTLSQLFSSGSVRHEDDYLTLQPHESTALFVCQAICGIMRDKIDDTKTLIAGK
                     NVNLSRTGMDSIDAMMLARTISRHFGITLSIRAFLGSSVTVRDIARLIEGVKSEDNLSQ
                     FDLYAKYESIWEELRGVVRGLTPSDKPQLCDKTPAGMSVFLTGGTGFLGTHILRQILQD
                     PRVELVTVLTRAESPAHALSKIVESAKIAQWWQESYRNRIDAWVGDLARPRLGLSDDHW
                     ARLCGYGEHKFTSIIHNGAAVHWGYDFEKLKPVNVMSTFWLLVSLFIAGPLVNFTYVSA
                     LLPECDGLTDREIALKTSDDGYSQTKYVSELLVKNFKEQLCNNPIAIVRPGLLIGSAEH
                     GVANVGDYLWRVVSSAFSVGAYISEKGDAWIYIAAVDWVANQVIREALYESTTDLRIIN
                     VTDGLTVKEFWRAIQIASPRQLNALQSEDWLSLIRQQLDVTGKSHPLWPVISFLESSKG
                     CLGFSHNLPPQAHSLSSMIITALIKNVRYLASLGLVSWTTTGSNCDHSVQQRIFRRVL"
     aSDomain        13817..15004
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_AMP-binding.1"
                     /evalue="6.60E-83"
                     /label="malG_AMP-binding.1"
                     /locus_tag="malG"
                     /protein_end="621"
                     /protein_start="225"
                     /score="270.4"
                     /specificity="substrate consensus: Pro"
                     /tool="antismash"
                     /translation="FSEQAKKNPTATAVQTSEGSFDYGRLDELSSALACHLSSNGLTRG
                     TPVPLLFDKSMWMVVATLAVLKAGATCVSICTGLPTKAIEDILEQTAAQLVLVSESQGL
                     RLSETRTQVVSDKTMQIWHTMSGKPELPQSDPTDLACIIFTSGSTGKPKGIMLDHIALV
                     TSIRNHGPSLGISSSSRALQFSSYAFDMSFYETYTTLLSGGCICIPSETERLNSLPQFI
                     CDHNVNWAFLTPSVLRDFHPSEFPSLRTLATGGEPVGADIANEWAGRLQLFNLWGPAEA
                     TICATGPILPGVWIPGTFGKAVGCIAWITQAENPDELVPIGAVGEVLIEGPVLAQGYSG
                     DVEKTKASFIPFPKWRERFELTPRGRVLFRTGDLAQYNPDGTIRYVGRMGTVVKVG"
     aSModule        13817..15640
                     /complete
                     /domains="nrpspksdomains_malG_AMP-binding.1"
                     /domains="nrpspksdomains_malG_PCP.1"
                     /locus_tags="malG"
                     /monomer_pairings="Pro -> Pro"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       14003..14035
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0001"
                     /evalue="5.80E-02"
                     /label="NRPS-A_a2"
                     /locus_tag="malG"
                     /protein_end="298"
                     /protein_start="287"
                     /score="7.3"
                     /tool="antismash"
                     /translation="LAVLKAGATCV"
     CDS_motif       14234..14293
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0002"
                     /evalue="1.50E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="malG"
                     /protein_end="384"
                     /protein_start="364"
                     /score="29.9"
                     /tool="antismash"
                     /translation="ACIIFTSGSTGKPKGIMLDH"
     CDS_motif       14774..14863
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0003"
                     /evalue="1.20E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="malG"
                     /protein_end="574"
                     /protein_start="544"
                     /score="33.6"
                     /tool="antismash"
                     /translation="PIGAVGEVLIEGPVLAQGYSGDVEKTKASF"
     CDS_motif       14969..15034
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0004"
                     /evalue="4.60E-04"
                     /label="NRPS-A_a8"
                     /locus_tag="malG"
                     /protein_end="631"
                     /protein_start="609"
                     /score="13.0"
                     /tool="antismash"
                     /translation="YVGRMGTVVKVGGQRVDIDAVE"
     aSDomain        15446..15640
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_PCP.1"
                     /evalue="4.00E-13"
                     /label="malG_PCP.1"
                     /locus_tag="malG"
                     /protein_end="833"
                     /protein_start="768"
                     /score="41.3"
                     /tool="antismash"
                     /translation="ETLLRLLVSDVLGIDRDHVAMNSRFFHLGGDSLAAVKLVALARQQ
                     GIQLKVEAILQSCSLREAAG"
     aSDomain        15770..16588
                     /aSDomain="Condensation"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_Condensation_DCL.1"
                     /domain_subtypes="Condensation_DCL"
                     /evalue="3.40E-34"
                     /label="malG_Condensation_DCL.1"
                     /locus_tag="malG"
                     /protein_end="1149"
                     /protein_start="876"
                     /score="110.2"
                     /tool="antismash"
                     /translation="EEIYPSTPLQEGLITVTSTFSASKPYVDKILFTLSATADLDRVRD
                     AWNHVVAANDILRSRIILSPAGKAFNVVVRSEPSWQYYKTVQQYLENDNAQDMTFGKEL
                     ITFNLIASHDQSASARSIGITIHHALYDNWTVSLLHKQAEDAYRGELVEPCSFSTFSHY
                     VLQQSPDINKEFWRKQFLDLRAGTFPELPSSDYVPRANSSSQHLYKGQHQRRDFSMATN
                     IQLAWALLLSLYTNSPDVVYGLVVNGRMAPMPGVGGLVGPTIATVPFRTTV"
     aSModule        15770..19780
                     /complete
                     /domains="nrpspksdomains_malG_Condensation_DCL.1"
                     /domains="nrpspksdomains_malG_AMP-binding.2"
                     /domains="nrpspksdomains_malG_PP-binding.1"
                     /domains="nrpspksdomains_malG_TD.1"
                     /final_module
                     /locus_tags="malG"
                     /monomer_pairings="Trp -> Trp"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       15845..15952
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0005"
                     /evalue="1.80E-06"
                     /label="C2_DCL_024-062"
                     /locus_tag="malG"
                     /protein_end="937"
                     /protein_start="901"
                     /score="20.2"
                     /tool="antismash"
                     /translation="YVDKILFTLSATADLDRVRDAWNHVVAANDILRSRI"
     CDS_motif       16484..16579
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0006"
                     /evalue="7.40E-10"
                     /label="C5_DCL_263-294"
                     /locus_tag="malG"
                     /protein_end="1146"
                     /protein_start="1114"
                     /score="31.3"
                     /tool="antismash"
                     /translation="DVVYGLVVNGRMAPMPGVGGLVGPTIATVPFR"
     aSDomain        17090..18262
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_AMP-binding.2"
                     /evalue="3.50E-77"
                     /label="malG_AMP-binding.2"
                     /locus_tag="malG"
                     /protein_end="1707"
                     /protein_start="1316"
                     /score="251.5"
                     /specificity="substrate consensus: Trp"
                     /tool="antismash"
                     /translation="VRSERTAVSAWDGSLSYRELDRFSSIVARHLQAVGVGKGTITPIL
                     FEKSRWVVVAMLAVLKTGAAFVMLDTNQPLQRKQGICRAVRATTIATSASCAHESKVLA
                     NSIYVLDEASITKTDTNQFLPLVEVSPNDLAYVVFTSGSTGEPKGVLIEHASSCSASRA
                     QAAKLGISPDSRVLQLSSYTFDSFAVEILASLLAGCCICIPSESESSNDIAGAVRRFSA
                     TWLCITPSVLGLTNPDEVPSLKTVVAVGESARPSQIRLWSTRVNFICGYGPSECSTGAS
                     AQLIRSAGSDPRIIGSGMGSCLWVAHTDDHNVLVPIGAIGELLIQGPIVGRGYMNSPEK
                     TRAAFLESTAWIPEFRQVATERFYKTGDLVRQNEDGSIVYLGRKNREVKLR"
     CDS_motif       17258..17299
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0007"
                     /evalue="1.20E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="malG"
                     /protein_end="1386"
                     /protein_start="1372"
                     /score="12.4"
                     /tool="antismash"
                     /translation="LAVLKTGAAFVMLD"
     CDS_motif       17492..17551
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0008"
                     /evalue="5.10E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="malG"
                     /protein_end="1470"
                     /protein_start="1450"
                     /score="31.2"
                     /tool="antismash"
                     /translation="AYVVFTSGSTGEPKGVLIEH"
     CDS_motif       17663..17689
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0009"
                     /evalue="9.90E+01"
                     /label="NRPS-A_a2"
                     /locus_tag="malG"
                     /protein_end="1516"
                     /protein_start="1507"
                     /score="-3.5"
                     /tool="antismash"
                     /translation="LASLLAGCC"
     CDS_motif       18035..18124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0010"
                     /evalue="9.70E-13"
                     /label="NRPS-A_a6"
                     /locus_tag="malG"
                     /protein_end="1661"
                     /protein_start="1631"
                     /score="40.3"
                     /tool="antismash"
                     /translation="PIGAIGELLIQGPIVGRGYMNSPEKTRAAF"
     CDS_motif       18227..18292
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_malG_0011"
                     /evalue="5.20E-07"
                     /label="NRPS-A_a8"
                     /locus_tag="malG"
                     /protein_end="1717"
                     /protein_start="1695"
                     /score="22.1"
                     /tool="antismash"
                     /translation="YLGRKNREVKLRGQRLDLEEVE"
     aSDomain        18704..18907
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_PP-binding.1"
                     /evalue="3.30E-10"
                     /label="malG_PP-binding.1"
                     /locus_tag="malG"
                     /protein_end="1922"
                     /protein_start="1854"
                     /score="32.3"
                     /tool="antismash"
                     /translation="AICGIMRDKIDDTKTLIAGKNVNLSRTGMDSIDAMMLARTISRHF
                     GITLSIRAFLGSSVTVRDIARLI"
     aSDomain        19055..19780
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_malG_TD.1"
                     /evalue="2.80E-40"
                     /label="malG_TD.1"
                     /locus_tag="malG"
                     /protein_end="2213"
                     /protein_start="1971"
                     /score="129.9"
                     /tool="antismash"
                     /translation="VFLTGGTGFLGTHILRQILQDPRVELVTVLTRAESPAHALSKIVE
                     SAKIAQWWQESYRNRIDAWVGDLARPRLGLSDDHWARLCGYGEHKFTSIIHNGAAVHWG
                     YDFEKLKPVNVMSTFWLLVSLFIAGPLVNFTYVSALLPECDGLTDREIALKTSDDGYSQ
                     TKYVSELLVKNFKEQLCNNPIAIVRPGLLIGSAEHGVANVGDYLWRVVSSAFSVGAYIS
                     EKGDAWIYIAAVDWVANQVI"
ORIGIN
        1 ctatgcagct ggcctggtag gggttggtag ctttaactcc ttcgaggggt cgtatttagg
       61 cgcagtattc caggcagcgt aaagtaacgc ttcttcttct gcggtcagcg ggggatcaaa
      121 ggtaacggcc gtttgcggct cggtgcccag aagaccgcat gagtggcact ttttccaatc
      181 tgggcggagt tggagccatg ccccgcaacc cgagcattgt ctcgtataga tgtccctgct
      241 tgtcttccct tcgacgaaat tcaaagaccg atcgaaagag cgcaggatcg catcccaccg
      301 gagactgaag tcgtctgcgg ccacggcagc acttttaatt cggttcgaaa acgcaagcaa
      361 ctcatcaacc atcgcatcgg gaagtcgctc atcgaggggg acggtttcga tatgctcaat
      421 gcatttctgt gcgacttgtt gatattcagg caccatggct ccccaaaccc atttaatcgc
      481 gtaatgtgcg aaggtttcaa tgttaacatc tgacaaatat cgctctatgc cagcgaaaaa
      541 ctgccagagg catgccacct ggggacctaa acgtgtatcg cgataacaga cgtagttaaa
      601 tcgattcatt tgctcgagtg ccggaactag ggacttgcaa taatcgtcat atgggaccag
      661 taattttcga atagaggact ccgccgcatc tgcaggcgca cttttcccaa tctccacaat
      721 tcggtgcgaa agctgtgcgg cccatgttga agtcgacatg ccaacattaa tccccggaga
      781 atagagcggg ttggtgaaac cacaggcatc accaatggca agccagccag gtccagaaac
      841 cactggagac tggtatgcca gcgtcttacg gatgaaccat gtggtcccag ggccataaag
      901 attttcaata agctcaaagt ttgacatgaa ctgctgaagc agctcatact tctgaacaaa
      961 gtagttgaat ttttgctctg cctcacgggt cccataggct gagagatctt ccgggtactt
     1021 gacatcattg cgcacggcaa agccaatact tgtcacccac tgaaacttga gcccaaacat
     1081 cctggcaagc tcttcagaac tcgggagttc atcaccaggt actccggcgt cagcgcattc
     1141 gagtatgtat gtcaccatat ccatcaagtt cgctatgagg ctcccttccc aagagggtag
     1201 acgaataacc cagacccaac cttccggaaa acacaggtgg tttgtgtgat caccttcata
     1261 gagatcaaag ggaatcttgc tctcatcctt tggggcagtg aaataacccc agaaggcgtt
     1321 gcagttccat ccatcgaatc ggtgtcgggg ggctttcttg gagcaaaatt ggcggaagcg
     1381 gcctgttgcg tcaacgaaga gggctgaatc tattgtcttg ggtgtgctat catatttgcc
     1441 ccgggagact gcgatcttgt tgccctggcc acccccttgg accaccgtgc ttttaaaatc
     1501 cacctcccgg ccgtgataga cattgactcc atttcgttgc gcaagaattg taaagagcag
     1561 ctcgctcatt ggccgctcaa tctgtaaact ggctaatacc aaacctggag ccccaacact
     1621 gcagaagtct gtgtactgcc cctggttctc tcgatcaaga aagtaaaagc acagcccatc
     1681 cttgagtccg aatagtcgaa ggaggtatgc cgcggagatg ccgtggagtt tgcaccaggt
     1741 gtaaaagata ggtagagtgc tctcgccaat cttgtaacca ggcctagtgt tcttctcaat
     1801 aacggagatc ttgaggttgt tcggtttata ctttgaagcg tgaagggcat agatcagacc
     1861 atggatacca gcaccgccca ccaccacatc cgattcatct gggagctcag atccagtagg
     1921 attattggag ttgagaatct cagcgtcgct gagattgcct gccgcagccc tctcggtaaa
     1981 cgtatacttt ggtgtcggcg ccatggtgtt caaggcaaac gaggataatt aaaatgttcg
     2041 gatttagtta gagcggataa aagatgctta ataggaataa acctgggccg caattgaccc
     2101 cttcggtgtt gcctttataa attatgctct gatggaggaa tgtcagagtc ttcctcctgt
     2161 cctctttagt ccgcctgata acccaaacag aacactcatg gccctggctg ggtcctgtgg
     2221 cagggactgg aaggcgcaaa acggcccaag agaaggttgg gatcatctcc ctgcacactc
     2281 tgccggagtg gattcagccc gcaccatcca aagtgaggcg cctgcctacc cagctgtgtt
     2341 cttcccttga cggagaaagc tctccgagtc aggcggcccc ccgtttctga agtcgagaaa
     2401 gagtttgggt aaccaccgac tccacaacgt gaatggatga gcaggctggt tgaaaattgg
     2461 gtatccgtct gcataagaat caggtcgatc gaacatgata tggctccaga tttcttcgtg
     2521 tccacgtctc gtgaccggta tttcctcggg accaacaccg cccggatttc tagccagtct
     2581 ctggcagaat ttgggtccag gctggaccaa gatcctttga tggcctgttc aacatcaatt
     2641 cttcagagtt cagagagctc agaaagcggt ggatatgaca cagatggagt ggccatcggg
     2701 atctactgat cttcgtcctt cgcccgcgcc gatgatgata tctgagattc caataaaggg
     2761 gcgttgactg aggctggaac agcgtcctgg actgctcatc aatccggaat gttcagcttg
     2821 gtgatgggta gtgatagtta atgctaaata ctaattacct tagcacggat ttggtccgcg
     2881 cagttctgtt gatgacggcc ccaggggttg aaggagcccc ttacgggcag accggagcaa
     2941 caagtatatt gcagcgatat ccctcccaca tccatcttga tagtcacata tagtttgctc
     3001 tcttttgttt accctaatgt catctgctga ttcaactctc ccatttcagc atgatgcctt
     3061 cacaaagccc atatcatgct ctcagtagat acttttcttt cccaaaccgt gaccaccagg
     3121 cctggtggac gggaaagggc cctcttctcg ggaatatgct cgcggatgct ggatacccgg
     3181 aacaacagca gtaccagtat ctcaccttat tcaacttgca tcttatccca gccttgggac
     3241 cgtccgaaag ccacggtgca ggcatcgacg gagcagaatg gaaatcgctc ctgtcgggtt
     3301 ctgggaagct cgagtttagc atgacatacc gaaaatcggc ggtttcgttg cgcattgcct
     3361 ttgagccgac gagcttgctt gcgggtacga agaaggatgt gtttaataaa cggcgcacgc
     3421 aacagctcct gggtgatctt gagagacttg acatcgacat cgacacggtg ttgtatcatc
     3481 ctttatttga taccctggtg gtgtccgatg aagaagaggc agcgttgcaa aacgctggga
     3541 ctgtgattcc cgactcgtct aggacacagc agctgctcgc tttgaatttg attgaaggga
     3601 atgttagagc tgatctctat gtctatcctt acgtcaaggc gcttgccact ggaaccgcaa
     3661 gttcgacgct tttgtgggca gccgtgaaga agatagatcg gtataacaga tttcgggatg
     3721 cgttgtcaat cctgaaaggc tactttgaaa catatccgtc ctcaactaca aacccgatgt
     3781 ttctctcaag tgacctcgcc gcaccaagga acgctttctg ccgtctcttc ttttccgaaa
     3841 cgaatttcag ttgggagaga gtgcaacatc tatggaccct cgggggaacg ttaagcgata
     3901 agccaactct caaaggtttg gaacttgcaa aaatcctctg ggacattttg ggaatttcca
     3961 cagcgccggc atccccagac tcatttcctc ttctattcac attcgaactt cgtccggaac
     4021 agccatacct gcgacaaaaa ctcggcatcc cagtctctgg gttgacggag agcgcaatcg
     4081 cgaatgcttg cgtcgctttt tttgaacgtt tgggctggga tgaccatgca gcttcctatc
     4141 gaaccaactt gtcagcttac tagtgagtct ccctttctgt tgtccattga atgcctcgaa
     4201 ttaatgcccg ctttttcaag cccggaccaa gacctcaaca agccgcttgg caaacaggcc
     4261 tggcttgctt tctcctatgt tagcgaagaa ggcccaagct tgacggtaca ccactattaa
     4321 tcaggcgcgc tgcttggaga actgatcccc gcggatgatg agtttcgttt ggtcagaata
     4381 gaggagtaag attttttaaa cgtctaagtt gtgtcacaag ggcaaagtcc gacgatagcc
     4441 ttgtgctgtg ttgcagagcc gaataaaatt atacgcaaaa tgacaggagc attggccgtc
     4501 aatatcaatc catcttttgc attggtagaa gtaggccaat ggaaacatgc cgtccatttc
     4561 ttttttttct caagactacg aagggagaag actttgctag agctccggcc caggcaatcg
     4621 gagtatgtat gcttcgggac tggatttcat caatgccgcc cggattgaaa gaaaaaatcc
     4681 gccgagcatg ttgaacccac atccacccgg tcaaaactgc aagcctcggc gcgatacatg
     4741 aaagtgtgct tgcgaaaggg tccagaaatg agaaactgcc ttatccatct cccacttctg
     4801 gtcttgctcc cctacttatc ataatttttt cttcacctag tccttcaagc tccttttcct
     4861 gttccccaac ccgactggga tcaagatggc acctaccagg agatctagag acctacttcg
     4921 cgggaagaat gtcctcatta tcggtggaac atctgggatt ggttttgccg tggcccagct
     4981 ggtgatagag cacggagcca tggcatgcat cgcgggctcc aatccaacaa agttgggaaa
     5041 ggctcttgat gccctgaagc aacacccaga ccgcgaccct atagctattg tccagagtgc
     5101 gacgtgtgac cttttcgacg tacccaatct tgaacagaac ctcgacaatc tcctcaagct
     5161 ggcggccggt gattcgaaaa tccatcacat cgtcttcacc gccgcagaca tggtgcagcc
     5221 tccgcctctg gcgtcagtca cgattgagca gatccagcgc gttggcacga ttcgatttac
     5281 agcaccgatg ctggtcgcca aattgcttcc gaaatacatg gagctctgcc ctgaaaattc
     5341 gtataccttg accagcggat cgcatgcaaa acagcccgat ccgggatgga gtcttgttac
     5401 gggatactgc ggcggcgtag agggtttgat gaggggcctg gcggttgaca tgatgcccct
     5461 gcgagtcaat gttgtgtcgc ccggcgctgt tctcacgccc gttttgcggg atatcctggg
     5521 ggactcgttg gagatagcgc tcgatgcggc gagaaagaag tcgactaccg gaaggattgc
     5581 acggccagag gacgttgcgg aggcatatct ttacattatg aaggatcaga atattactgg
     5641 cactgtcttg gagaccagtg cggggatgct tttgcgctga agagccccca tctgcagcgg
     5701 tgcgttttac tttcggagta taggaatcag ttgtagccag ttacttgctc agtaattgaa
     5761 tatggacagc aatagtctca tttaatctcc atatctcaaa agtcgctcaa tatagatacc
     5821 tagggagtca ggatattcag ttggatgacc atttcgactt gaccaacgca aaacacaaca
     5881 gtttttatta ggagagtccg acagtgggta cggtctctac atagctaata ccgtattcaa
     5941 tttggtaacc gtctctccca ttgtttgtgg atccaatcct tgaaggctgt caatgacccg
     6001 tccgtaactc cctgagcaag cttcgcctcc ttcttcagag ttgttgcagt gtcaatttca
     6061 ctttcatcag gcacgaacca tttcccgcca ttcgaataca ttgagtgaaa gatcgcgcgc
     6121 atctcttctc gacagctcgt gccgtcgagg ggaatgtcca cccacgattt cagtctcacg
     6181 tagcgcgcct tctctccggt aactgtaatc caatcccacc gtcagtaagt cctctccatc
     6241 tcgaagcccg aaaaatcgat tcggaggaaa tgaatacatg ctgtgccggt ttacgtacct
     6301 tccatgaaat cctccaccat tttttcaaat gaaatcagtt cgcttgatcc ctgaattgtt
     6361 ttgagatgat aggaatccgg atccagaaaa atgccatgga caatgtcacc aaagtcgtct
     6421 tcaacgctca cccagggcat cctctcatca ccaccataag gaggagtcgc aagaagatat
     6481 tcgccggtat cacgcttgaa ccaagggaaa ccaccgagag attgacagaa cgactccgca
     6541 aggaacgctt ccataaacga tgctggcacg ataggtgtga aagtttggaa gccctttctt
     6601 ctcccatatt gttccacgta gtacttgcct acgcaagacg gtcaacattt aggccgaagc
     6661 atgggtcatg ggactgttgc ttgagtgaac agaaatatcc ccttactttc aaagccctca
     6721 ctgtggactc tgccatttgt gtacttgcaa aggttgaggc cagaactata cacgacgtgt
     6781 ttcactccag cttctttcgt ggcgtcgagg acggttgaac caaggtcata atcgctacgg
     6841 ccaccgggga ttttataaat ctatcaagtg tcaataagat cagtctcatt cagccatctt
     6901 tgaggacagg ggctagaaaa aactagctta cttcttcgtc agaattagta ttaacaaatg
     6961 caccccagct acccataaaa gcactgacag tctccgactt gttgaagccg tctgctttga
     7021 ctaactctgc gccgagtttg gcacatgctt gggctttctc cgaagtaggg tctcgggtga
     7081 tgactcgaac atggaacagt ttgtctttgt gtgccagtaa tgatcggacg acactactgc
     7141 cttggtttcc tttgattgga aatcgggctc tacgttagct agactaataa atcagacatg
     7201 tagtcgacgg gggattgctt tacgcaccag taccaccaaa aactgtgaca agtctctttc
     7261 ctgtatccat tgttccagtt ttctgtgata gatgtttttc tcttgaatcc aggcgtcaac
     7321 gtgcaacaat tcgctgcctt cttggtgcga gttctgagaa ggactcgagt gcccagctta
     7381 aaaagcattt ttcccaatgg agtccataag acacaaaacg acttatcaga tggcgcatct
     7441 gattgatttt ccaaccggga tgaccttcac tagtcctgat cgaaatagct acctagttag
     7501 ggtactgcgg acggtttcca aacacacagg ttgggatgag aatacttggg acttgggtaa
     7561 actggagaat tatgactggt gccacctaat ccggatcgct agctggttag gaacaccttg
     7621 catccggtgt aacgtttgaa gatcctgagg ctaattcagg tctcatggct ggcacctcgg
     7681 acctggcccg tcctgtaatt gtccccattt gttcgatcca cgggaaggaa atccatacag
     7741 actctgtgcc cgatttccta gcatcgtcac ctgtgacctt atctcacctg gctgctgatt
     7801 gccccgtaaa agcgactgcc caaaattgga ctccctgctg agagaagcgg ggctagtaat
     7861 atgttcagag cggtttcaaa aaacccataa gacctacagg agaatcaaaa agcctcaaag
     7921 tcagggccga gtggtagata ctctgcctga ttcacctttg atcttccgcc catcatatcc
     7981 ctatatcaca acttagcaga cctgttcata gtccgagctc ttccaggtag ataaagacga
     8041 cagaaaatga cagcaggtcc gatgggaaac aaaagcacgt cagatattga cagtgtgctg
     8101 gtatataagt cgctttcacg atatctcaag ttctcggaga acgaggaagg ttggtggcat
     8161 aaaacagcgc ctctgctcaa caaaatattg gccgctgcga aatacgatgt gcatctccag
     8221 tatcgatatc tggtattcta ctatgccgct tgcgtttctg ccctgggacc ttatcctcag
     8281 cgattctcga gttccatcac ccgaagcggc ctcccagtcg aattcagcgt caactatcaa
     8341 aacaattcga aaccgatcgt gcgcatcgga tacgaaccga tcagtcactt gagcggaacc
     8401 gaacgcgacc cttacaacca taagacggct tccgagatag tcgctaccct ctcaaagatc
     8461 caacccgact ttgacccacg gcttttcaac tactttgtcc atcagctgag cgtcaacaaa
     8521 gccgagtccg atgtattaaa tggtgccaat gtcgaaggta gcgagatgaa atctcaaact
     8581 gcctttggat ttgacttggt caacggagag atctctgtca aggggtatgc ttttcccgcc
     8641 atgaaatgtc aggtatcgca acagtctctt tcacaattgc tcaaggcggc aattaatggc
     8701 ttgaaaggcg agttcgactg tgcctttggc ctcgtcgatg agtatatgga gcgttgtggc
     8761 gggtacaacc aattctcgtt tgtctcctgg gattgcgtcg ttcctgcgaa gtcccgcttc
     8821 aaggtctatg gagtccacaa cgatgtaacc tggaaaaaga tcgaagatat ctggacactc
     8881 gggggccaag ctaccagcgg aaatgtcacc aagggcctgg agttgttgaa ggaattgtgg
     8941 acactgattg acttggacga aggtgaacgt gggtacacgg gacgttttga cgatgcgaac
     9001 gacaatggga gcaatatcca gagtccaatg gtgtggaatt atgaactcag gcccaacaat
     9061 ccatggccgt tggcaaagtt ctactttccg gtgcacgggg aaaacgacat gaagattgtg
     9121 aaaggcttag cccgattctt cgagaatcgg ggttggactg agctggcccg atcctacgtt
     9181 cagacggtgt cctccttctt gtaagtcctc tatgccaact cactccaatt cgcgctccta
     9241 gcattggatc cgagtaccat gagtgatggc agaaataact aacgggttct gagtagtcct
     9301 gatcgagacc tgaatcaaac gcagcgcctg gtatcgtgga tttcattcgc ctacactgaa
     9361 aagactgggg tatacctgag tgtttactac cattcttcag ccgattatct atggatatcc
     9421 gagtctgggg aaaagagagg tcaaggagat ggtgcttgac tctagtcttg gatattcgac
     9481 tgtctcgtgc gagaaattat cccagccagg ccggactaac gtgcgagtta tcgggttgtc
     9541 ctctagaata agtttatcga ggcttttttt tcggtttccg tagtcaagaa aatgtcccca
     9601 agaactttca cccgtattct gtgtagtgga catccattgg agcatgctgg gtcgaaaact
     9661 tcgtagctac cgatgtgttg tgaagtcggt cggaagacca gtgccaacca gcggttagtt
     9721 accacttttg gcttctctga aagatagcca aatattgtaa gaaatggagt ggcaatctag
     9781 tgctatgctc cggacttcgt acggagttgt gtatttcgat tttgagtttc cgaacgggca
     9841 acctaggcgc cccaaaaacg agctacagct ggaagaaaat gtttgatccc agggtgcgaa
     9901 acagatttgt gacacataag ccactgggcg atttttgaat ctggctacaa tcgtgatgcc
     9961 attcgaacaa aagctctgat tctgcaatgt gggcttctgg cgcctggtgc cggtctggaa
    10021 gagctgctgc agacttcagc tcctcacagc ccgtatccat atgctttcgg tcagctggag
    10081 cccgcgcatg gaagcatggc gccttgccga atgtccatct tgtattacac acgatatttc
    10141 gataacaact gcccatcttt tggacagcca acgaccaacg ataaatgagt ctgatgtaat
    10201 tctagcccgg gacagaagcc tcaggcgatg gaggtcatat ttcaggaaca ttaagccgct
    10261 catatctgcc actggctacc gagacggtga gagatccgag ttcaatttgg gggcccgaac
    10321 ccttaccgtt ccgacgatgg gcacgcaaca tgaggtaaaa gggaagcggg accgacactt
    10381 tcaggcttga ttaagtgaag ccgaccagag agtatggaga tccattctgg ataatgcaaa
    10441 gcgaccctcg ctcgattcaa aacctggcca aagcatgcca tagtccactg tcggccctcg
    10501 tgcacattcc ctcatcgtcc cagcgttcac ttcccactcc gactctggta atgaacagat
    10561 cctctggatc ccatgctcgc tttactttca agagccggtc gtagttcttc ccccagaatg
    10621 aatcctggaa gtaaacttca ttgggataag ccactgcaag ataagccccc tttcgaccac
    10681 cctcgagaga acgaagtcgg ggcaattgat cattctccaa ttcgctctca atggatttga
    10741 gggtttctaa tgtgtatcct ggaggcactc cacgaccgac tgtgagtgaa agaagagcag
    10801 atcgccagtc tggatggaca gcactgttga ttcgattttt gttgttcaca acctggccgc
    10861 caccaaaagc gtccacgcta aacgatgatc caggacccaa ccgtaggtcc gacaaggcgc
    10921 tggtcacttt ggcagggccg tccttggatg cgacaagatc ataagacagg aacacgctgc
    10981 ctgggatcac actgatgcca gccaaatcga cgcctttggg ggctgcgaga aagcggctga
    11041 ggttgccctg gaagtcatgg gacaatttaa aggggatacc gaagtcatcc aaagcgcgct
    11101 ggagtgcaag tagtgaaact gcaccctttt tgttaaaggt atatccttcg aatgaggcag
    11161 aagccccgcc cgtggaggaa gcaggaagaa ctatcatacg ggcagaattg ccggcatccg
    11221 taagctcagg taggattgaa agcacggttt tgacaccagc ccaaaatatt gcatccgccg
    11281 agggggtatt gatttgaatc ccggtcaccg tagccggaag gtcagcgaac gcgcggagtg
    11341 taacagaagt gatgacacca aatgtaccgc cacctcctcc acggactgcc cagaatagat
    11401 cctcattttg atattggttg gcaatgatat gactgccctg accgccaaac aaaacaaaag
    11461 aatgttagtg atgcctcaat agttggactt ccacacaatt gactctggat atgaacctac
    11521 atcggcggtc acgatttcca cctgaagaac atggtcggag ccgaggcctt tcgatggact
    11581 caatattccc atcccaccgc tctggatgaa gccacccgcg atgccaacag tactgcaggc
    11641 ccccccgagt acaacaaatc ctttctcaga gccagtagcg tagagctcgc ctgtgagaat
    11701 gcccgctcct atagtgactg cggggcccat gggctcagcg gatccctgag taataaaggg
    11761 cacgaaattt tccgtgtaat tgatgccctt caacccactt gtaagaattt gcagggaacc
    11821 aggggcactg gatcgccctg ccatatcgtg accagtgttg cgaacgacta ggcgtaggtt
    11881 tcgatgtttt gcgaaggaga ctgcctgttg aacctgcttt gtcgactcaa ccgccgcaga
    11941 gtacagtggt atacgtccct gagcgcaacc atcgacagct tcgcgtacaa tctgacaact
    12001 ctggtttttc tcaggccagc tttcccagct cacgagctgt agggattcta aacaataaat
    12061 cagccgaaga gccaggtgct cagaaagata tatatcaaca taccgggatg gtcaacacgc
    12121 caggaagagt tatgggtcat cgcaagcact tcgtcacatt tctccttgtg gtaggccgat
    12181 tgctgacatg gaagcccaac aggcctcaga tgacgtagct tgccatcgat tgattgattc
    12241 aatgatgacc actcagcggt agtaggccaa caagcatctt cttgacgaca acggcaaatc
    12301 gtgctcctcc gttgggtttg gatgccaatt gctaggataa gcagggcgaa agtggcagtg
    12361 tatttcattg ctggcaacat cactgacact tgtacggata gtctgaagag gagttaaaaa
    12421 gaattttgaa ggaagcagtt caatcgcaga gcagacctct tctcaccttg cacaatcttg
    12481 caaggtggga aaagaatcat tgagggaaac aggagcagtt ggtaccggta gctgcaacgt
    12541 cccacaaggg accaatctcc ttaccaggaa acgagtcaag cgaaatcttg gagacgaaag
    12601 attcgtacag ccgccaactc cccccactgc ggcccggtga actttgcgat tcagcttcct
    12661 aataagatcc cgactaactt aaagtctaga tgtagtgatt aggtgagatt ttatgatcat
    12721 gcatgattgg cggtcaaaat gttgcctctg tctatcaata ttagcatcca cactgcctgg
    12781 ccgacaatga tcgtctggcg caataactta ccaaaccacc cacttagata ccggacactg
    12841 gaggcgggtt tgtccgaagg ctgcctgaac tcatgaagtc ggagatatat attatgcact
    12901 tttatattct gaccgtgtgt tgcttaaatg tcatccatat cccaagccat acctgtccga
    12961 agttaataat cgcacctggg catcgaaaag aaaaacttac tcatcgacaa tggtccaacg
    13021 gcaactcata tctaaacggc tcgggctcct atccatggat ggagctcatg agccaacaga
    13081 acgtcttcgt atattgtcga gaacgagatg cccgtttcaa tcaaacccta gcttggactt
    13141 catgtctgat gatccgcttc tgtcgtcccc aacagaggca atatgtttga atcattcagt
    13201 gacagacctc cggctggctg cggcactgaa gctgagctgg acatttctct tggctcatta
    13261 ctctggatcc agcgaaatac cgcttgatat ccgactcgaa tataggtata ttgatggaag
    13321 cgaaacgaat ttcgagccat tcgacgcgac attcgaggtc gacaaaaagt ctctgatcga
    13381 ggactccatc ggcatgatcc aaaacatgct cacaccgtcg acacgcccac acagcctgag
    13441 taatggaata aattcgtctc agagcgacaa acatgtacca gaggcccagg tctcattcac
    13501 cttcagcagt ggttcacgac ctgtgcttga aaaaggtgcc acaactcggt atgccgccac
    13561 tgtcttggaa ttagagtgct tgcaggggct gaagaaggaa tacctttgcc ggatcaactt
    13621 caacaggatg atgtggaacg tggaagaggc gacgggaatt ctgcgccaat tccgccatat
    13681 tgcccaacag atcgtttcag cagatgtctg tgccacactc agccaaatca acttgatgtg
    13741 tgagtccgat atcgaacaac tcaaacgttg gaactcaact gtccccgatc cggtgcttgc
    13801 ctgcatacac gagttgtttt ctgagcaagc aaaaaagaat cccacggcaa ccgccgtaca
    13861 aacgagtgaa ggaagcttcg actacgggcg tcttgatgaa ctgtcttctg ccttagcatg
    13921 ccacctgagt tccaacggtc tgacaagagg aacacccgtc ccactcctct tcgacaagtc
    13981 catgtggatg gttgtggcca ctcttgccgt gctcaaggca ggtgccactt gtgttagcat
    14041 ctgtacagga cttcccacga aggctataga agacatactt gagcaaaccg ctgcgcagct
    14101 cgtccttgtc tccgaatcac aaggcttaag attaagcgaa acccgaaccc aggttgtttc
    14161 cgacaaaaca atgcagatat ggcacaccat gtctggcaaa ccagaacttc ctcaatccga
    14221 ccctacggac ctagcgtgca tcatattcac gtccggaagc acgggaaagc caaagggaat
    14281 tatgctggac cacatagctt tggttaccag tataaggaat cacggcccta gtttggggat
    14341 ttcctccagt tcgcgtgctc ttcagttctc gtcctacgct ttcgacatga gcttttatga
    14401 gacgtacacc acgctattgt ctggaggctg catttgcatc ccttccgaga ccgaaaggct
    14461 caacagtctg cctcaattta tctgcgacca caatgttaac tgggcgtttt taaccccgtc
    14521 agtgctacga gattttcacc ctagtgagtt tccatccctc aggacactcg ccaccggagg
    14581 ggagcccgtt ggagcggaca tcgcgaacga atgggcagga agactgcaac ttttcaacct
    14641 gtggggtcca gcagaggcaa caatatgcgc gaccggacca atattgccag gcgtctggat
    14701 acccgggaca tttggcaaag ctgtgggctg cattgcatgg atcacacagg cagagaaccc
    14761 ggatgagctg gttcctattg gggcggtggg tgaggtgctg atcgagggtc ccgtgctggc
    14821 tcaaggttac tcgggggacg ttgaaaagac gaaggcttcc ttcattccgt ttcccaagtg
    14881 gagagaaagg ttcgaactga caccgcgagg acgggtactt ttcagaactg gagaccttgc
    14941 tcagtacaat ccagacggta caatacggta tgttggaagg atggggaccg tagttaaagt
    15001 cggcggccaa cgagtggaca tcgacgcggt tgaatatgca ttgcgccgga tcgatcggtc
    15061 ttctcacata gcggtcgagg cagtcgaact agagaaagaa actggtcagg gacctacttt
    15121 gatcgcgttc ctgtctagcg atatgaatgg agtgtccgga tctgaaaaga aacggtgctg
    15181 ttcaatcgac cctggatccc gttcctggga agcctgggca aatattgcaa tacgtctcca
    15241 ggacactctc gctggagtat tgccacggta tatgatcccc catttattca tcccagtttc
    15301 aacgattcca accaccccaa gcggcaaagc caacaaacgc cagttgcaag ctcttgtcct
    15361 gggccaatcc aaggcacacc tcctgcagtt gtgccgacag cggtcgccag atgcctcata
    15421 cccagagcag catctcactg agaatgagac actgttacgt ttgttagtga gtgacgtgct
    15481 tgggattgat agggatcacg tcgcaatgaa ctcaaggttt tttcaccttg ggggcgactc
    15541 ccttgcagct gtgaagctgg ttgcactcgc tcgacaacag ggtattcagt taaaggtcga
    15601 agcaatcctt caatcttgta gccttcgcga agctgctgga accatgatct ctgctggtga
    15661 aaagcagaaa ttgcagtcaa agacatcatt cgccattaac aaatgcgatg acaaacttgg
    15721 gctacttgaa gaagcgacgg tccagtgcgg aatttcagag tccgatatcg aggagatata
    15781 ccccagtacg ccgttgcagg aagggcttat aaccgtaact tcaacttttt cagcatcgaa
    15841 gccgtatgtc gacaaaatcc tcttcacttt gtcagccaca gcagatttgg accgtgtgcg
    15901 agacgcatgg aaccacgtcg tcgccgcgaa tgatatcttg agatcccgca tcatcctatc
    15961 tccggcaggc aaagcgttca atgttgtggt cagatcagaa ccatcctggc aatattacaa
    16021 gactgtccag cagtacctgg agaacgacaa tgcgcaagac atgactttcg gaaaagagct
    16081 catcacgttc aacctcatag caagccatga tcaatctgct tccgcccggt ccattgggat
    16141 aacaatacat cacgctctgt acgacaattg gactgtctcc ctgctgcaca agcaggccga
    16201 ggatgcatat cgtggagaac ttgttgagcc atgctcattt tcgacatttt cccactatgt
    16261 ccttcaacag agccctgata ttaacaaaga gttttggcgc aagcaatttt tagatttgag
    16321 ggcgggtacc tttcctgagc tgccgtcatc tgattatgta cctcgtgcaa actcatcgtc
    16381 tcagcacctg tacaaggggc agcatcaacg cagagatttt agcatggcaa caaatatcca
    16441 gctcgcttgg gcgctcctgc tctctcttta cacgaattcc cccgatgtcg tttatggtct
    16501 tgttgtcaat gggcgtatgg ccccgatgcc gggggtcggg ggattagttg gcccaacgat
    16561 tgctactgtc cccttccgaa caaccgtgga gaggagtatg agcgtccagg ccgccttaga
    16621 ggccattcag aagcgggttc tgtcaatagt ccctttcgaa caaaccggtc tgcaaaacat
    16681 tgcgcgaatg ggggaaggcc ctaaaactgc ctgtaacttc caaaacctcc tagtgataca
    16741 acaggacctt gagtttaagg gcgaagggat attctgccgg agacaaaact tggtcggagc
    16801 ggtaaacaat ttcccaggat atgggattat acttctctgt agtgcgacgg agcatggatg
    16861 ggcatttgaa atactctata gtaactcatt aattccagaa acccgcgcac gtcggattct
    16921 cctgcagctg gaccacctgc ttcggcaact cgaggttgac ccataccgac aactggctca
    16981 actggagctc ctctgtccat cagataaaag caaactaaca tcctggaaca cccagttgcc
    17041 cattcgagta aacgcgtgta tccccgaagt cttcggagcg caatgccttg tccggagcga
    17101 gcgcactgca gtgtccgcct gggatgggag cctttcgtat agggagctcg atcgattttc
    17161 ttcgatagta gcaaggcatc tccaagcggt gggggttgga aagggaacta ttacacctat
    17221 cctgtttgaa aagtcgcggt gggtggttgt cgccatgctg gccgtgctca agaccggagc
    17281 ggccttcgtc atgctagata caaaccagcc cctgcaaaga aagcaaggta tctgccgtgc
    17341 agtcagggct accaccatcg ctacgtctgc ttcgtgcgcc catgagagca aagttctggc
    17401 gaactcgata tatgttctcg acgaagcgag catcacaaag accgacacaa atcaattcct
    17461 tcccctcgtg gaggtttccc ccaacgatct cgcgtacgtc gtcttcactt ctggctcaac
    17521 cggagaaccc aaaggcgtcc tgatcgagca tgcgtcgtct tgctcggcat caagggctca
    17581 agccgcgaaa ttgggtatct cgccggattc tcgggtgctc caactctcat cttatacctt
    17641 tgactcgttc gcagttgaga ttctcgcgtc tctattggct ggatgctgca tttgcatccc
    17701 gtcggaaagc gagagcagca acgatattgc cggtgccgtt cggcgatttt cagcgacatg
    17761 gctatgcatc acaccctctg tattgggatt aaccaaccca gatgaagttc ccagcctcaa
    17821 gaccgtcgtt gccgtgggag agtcagcccg accgagccag atcagactct ggtcgacaag
    17881 agtgaatttt atctgcggat atggaccttc cgaatgctca acgggtgctt cagcacagct
    17941 gatacggtct gcaggctctg acccccgtat catcggttcc ggcatgggct cctgtctgtg
    18001 ggtagcccac acagatgatc acaatgtcct ggtgcctatt ggtgccatcg gtgaacttct
    18061 catccagggt ccaatcgtgg ggagaggcta catgaattca cccgaaaaga cgcgagcggc
    18121 ctttctcgag agcacagctt ggattccaga gtttagacag gttgccacag aacgttttta
    18181 caaaaccggg gacttggtcc gtcaaaatga ggatggatcg atcgtctatc tcgggagaaa
    18241 gaaccgagag gtaaaacttc gaggccagag actagatctt gaagaagtcg agaaccagct
    18301 ttcagcagca ctagaaatgg acattaatat agtggctgaa gttgtgaagc ccaaaggagt
    18361 cgattcccag ccggtactta ttgcattttt ccaggttgtg gcagatgtgg aactccggtc
    18421 tgacaatatt acattcctcg agttaaatcc ggatatcggc cttcggctcc tggatgcgga
    18481 agagaaattg cggaaaatcc ttccccctgt aatgatacct tctgtatatc tacaggttca
    18541 aagaatgcct ctcacaatgt cggggaagat gaaccgacag gccttgcgga ataaagcatc
    18601 caccagaact ctctcgcagc tcttctcgtc tggctcggtc agacacgagg acgattatct
    18661 cacacttcaa cctcacgaaa gcactgccct tttcgtttgc caagcaatct gcggcattat
    18721 gagagacaaa attgacgata ccaagacctt gattgcaggg aaaaatgtca atctatccag
    18781 gacaggaatg gactccatcg atgccatgat gctcgctcgc acaatttcgc ggcatttcgg
    18841 catcacccta tcgatacgtg catttttagg tagcagcgta accgtccgtg atatcgccag
    18901 gctcattgaa ggggttaaga gtgaggataa tctctcacaa ttcgatctct atgccaagta
    18961 cgagtccatt tgggaagagt tgcgaggcgt ggtcaggggt ttgaccccgt cggacaagcc
    19021 tcaactctgc gacaagacgc ccgctgggat gagcgtcttc ttaaccggcg gaacagggtt
    19081 tctgggaaca catattcttc gacagatctt gcaagatcca cgtgtcgagc tcgtgacagt
    19141 cctcacacga gctgagtcac cggcccatgc cttgtccaaa attgtcgagt ctgcgaaaat
    19201 tgcgcaatgg tggcaggagt cgtaccggaa ccgaattgat gcatgggtag gagatttggc
    19261 ccggccacgt ctaggtctgt ctgatgatca ttgggctaga ctctgcgggt atggcgagca
    19321 caaattcacc tcgatcattc ataacggggc cgcggtacac tggggatacg acttcgaaaa
    19381 gttgaagcct gtaaacgtga tgagcacgtt ttggcttctt gtttcgctct tcatagctgg
    19441 ccctttggtt aatttcacgt atgtgtcggc attgttgccg gaatgcgatg gactcacaga
    19501 ccgtgagatt gcactcaaaa cctccgatga tggctacagt cagaccaaat acgtgtccga
    19561 gcttctggtt aagaatttta aggagcagct ctgtaacaac ccgatcgcga ttgttcgccc
    19621 agggttactg atcggatcgg ctgaacacgg tgtggccaac gtcggtgact acttatggcg
    19681 cgttgtctcc agtgcgtttt ccgtcggggc ttatatttcg gagaaaggag acgcgtggat
    19741 ctatatcgca gccgtcgatt gggttgccaa tcaagttatc cgggaagccc tatatgagag
    19801 taccactgac cttcgaataa tcaatgtaac ggatggtctg acagtgaaag agttttggag
    19861 agcgattcag attgcgtcgc cccgtcaatt gaatgctctc caatccgaag actggctctc
    19921 tttgatccgt cagcagctgg atgtcacggg aaagtcccat ccgctatggc cggtaatttc
    19981 tttcctggag tccagtaaag gctgccttgg gttttcgcat aacctcccgc cccaggcaca
    20041 ctcactttcc tccatgatca tcactgcgtt gattaaaaac gtgcggtatc tggcctcgct
    20101 ggggttggtt tcgtggacca cgaccggctc taactgcgat cactcagttc aacagcgtat
    20161 ttttagacgc gtcctgtga
//
