BGC0000816 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000816 (Malbranchea aurantiaca)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	NRPS,indole	1	20,179	malbrancheamide A	NRPS:Type I+other:other	100%

BGC0000816 - Region 1 - NRPS,indole

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Location: 1 - 20,179 nt. (total: 20,179 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
indole: (indsynth or dmat or indole_PTase)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 20,180
Label		BGC0000816

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000816	1.44	NRP, Alkaloid	malbrancheamide A	Malbranchea aurantiaca
BGC0000811	0.41	Alkaloid	fumigaclavine C	Aspergillus fumigatus Af293
BGC0000293	0.38	NRP	acetylaszonalenin	Aspergillus fischeri NRRL 181
BGC0000348	0.37	NRP	ergovaline	Epichloe festucae var. lolii
BGC0001718	0.36	NRP	okaramine D	Aspergillus aculeatus ATCC 16872
BGC0001616	0.34	NRP, Polyketide	himeic acid A	Aspergillus japonicus
BGC0000900	0.33	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.32	NRP	dimethylcoprogen	Alternaria alternata
BGC0000405	0.32	NRP	δ-(L-α-aminoadipyl)-L-cysteine-D-valine, isopenicillin N, benzylpenicillin, phenoxymethylpenicillin	Penicillium chrysogenum
BGC0001717	0.32	NRP	okaramine B	Penicillium simplicissimum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000816	1.00	NRP, Alkaloid	malbrancheamide A	Malbranchea aurantiaca
BGC0000900	0.66	Other	ferrichrome	Aspergillus oryzae
BGC0001249	0.66	NRP	dimethylcoprogen	Alternaria alternata
BGC0002606	0.61	NRP, Polyketide	ochratoxin A	Aspergillus niger
BGC0002166	0.61	NRP	peramine, intermediate 1, intermediate 2	Metarhizium rileyi
BGC0002164	0.61	NRP	peramine	Epichloe festucae
BGC0001517	0.60	NRP	asperphenamate	Aspergillus terreus NIH2624
BGC0002199	0.60	Alkaloid	nanangelenin A	Aspergillus nanangensis
BGC0002248	0.59	Terpene, NRP	flavunoidine	Aspergillus flavus NRRL3357
BGC0001261	0.59	NRP	AM-toxin	Alternaria alternata

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 20179:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Pro - Trp)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

malG

Search NORINE for peptide: strict or relaxed

AMP-binding (225..621): Pro

nrpys: Pro

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: leu (Leu)

Stachelhaus prediction details:

Stachelhaus sequence:: DMYFAGLICK
Nearest Stachelhaus code(s):: Pro DMYFAGLICK (100% 8Å match)
Stachelhaus code match:: 100% (strong)

AMP-binding (1316..1707): Trp

nrpys: Trp

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DSVCVVGTGK
Nearest Stachelhaus code(s):: Trp DSVCVVGTGK (100% 8Å match)
Stachelhaus code match:: 100% (strong)