Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000816.1:
Cluster 1NRP / Alkaloid120179

BGC0000816, malbrancheamide biosynthetic gene cluster from Malbranchea aurantiaca. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Malbrancheamide A
SMILES string: Copy to clipboard
Molecular formula: C21H23ON3Cl2
Exact molecular mass: 403.1218 Da ([M+H]+)
Molecular activity: Inhibitor
Molecular target: calmodulin

Class-specific details

Biosynthetic class(es):
NRP / Alkaloid
Other (cyclic)
Thioesterase type:
None
Release / cyclization type:
Reductive release

Nonribosomal peptide synthetases:
malg (AGA37267.1)
Module 0
A specificity: Proline
Evidence for specificity: Structure-based inference
C domain subtype: N/A
Module 1
A specificity: Tryptophan
Evidence for specificity: Structure-based inference
C domain subtype: LCL
Alkaloid subclass:
Pyrrole/pyrrolidine

Gene cluster description

malbrancheamide (BGC0000816). Gene Cluster 1. Biosynthetic class = NRP/Alkaloid. GenBank JQ708193, positions 1-20179. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Fengan Yu (University of Michigan)

Literature references

1. Li S et al. (2012) Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm 3(8):987-996. doi: 10.1039/C2MD20029E.