Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000817.1:
Cluster 1Alkaloid16814

BGC0000817, methylarcyriarubin biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: methylarcyriarubin
SMILES string: Copy to clipboard
Molecular formula: C21H15N3O2
Exact molecular mass: 341.1164 Da (None)
Molecular activity: Cytotoxic
Molecular target: Protein kinase

Class-specific details

Biosynthetic class(es):
Alkaloid
Alkaloid subclass:
Pyrrole/pyrrolidine

Gene cluster description

methylarcyriarubin (BGC0000817). Gene Cluster 1. Biosynthetic class = Alkaloid. GenBank KF551863, positions 5678-12491. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Sean Brady (The Rockefeller University)

Literature references

1. Chang FY, Brady SF. (2014) Characterization of an environmental DNA-derived gene cluster that encodes the bisindolylmaleimide methylarcyriarubin. Chembiochem 15(6):815-21. doi: 10.1002/cbic.201300756. Epub 2014 Mar