BGC0000819: paraherquamide biosynthetic gene cluster from Penicillium fellutanum
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Location: 1 - 47,884 nt. (total: 47,884 nt).
This entry is originally from NCBI GenBank JQ708195.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000819
Short description paraherquamide biosynthetic gene cluster from Penicillium fellutanum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "Swiss-Prot refers to a different, extended gene sequence for gene phqN (https://www.uniprot.org/uniprotkb/L0E172/history)"
Biosynthetic class(es)
  • NRPS (Type I)
  • other (other)
Loci
JQ708195.1
via
Compounds
  • paraherquamide
Species Penicillium fellutanum [taxonomy]
References
Chemical products information
paraherquamide Evidence:
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C28H35N3O5
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGA37268.1
  • phqA
 1 - 1281 (+) prenyltransferase
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    • AGA37269.1
    • phqB
    		 1606 - 8955 (-) NRPS
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      • AGA37270.1
      • phqC
      		 9530 - 10696 (+) 2OG-Fe(II)-oxygenase
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        • AGA37271.1
        • phqD
        		 10913 - 11976 (-) pyrroline-5-carboxylate reductase
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          • AGA37272.1
          • phqE
          		 12804 - 13601 (+) short chain dehydrogenase
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            • AGA37273.1
            • phqF
            		 14289 - 16065 (+) efflux pump
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              • AGA37274.1
              • phqG
              		 17781 - 19064 (+) negative regulator
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                • AGA37275.1
                • phqH
                		 21682 - 23650 (+) oxidoreductase
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                  • AGA37276.1
                  • phqI
                  		 25396 - 26784 (-) prenyltransferase
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                    • AGA37277.1
                    • phqJ
                    		 29106 - 30377 (+) prenyltransferase
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                      • AGA37278.1
                      • phqK
                      		 31443 - 32934 (-) FAD monooxygenase
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                        • AGA37279.1
                        • phqL
                        		 34979 - 36840 (-) P450 monooxygenase
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                          • AGA37280.1
                          • phqM
                          		 37357 - 39638 (-) P450 monooxygenase
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                            • AGA37281.1
                            • phqN
                            		 43471 - >44349 (-) methyltransferase
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                              • AGA37282.1
                              • phqO
                              		 46048 - 47884 (+) P450 monooxygenase
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                                Biosynthesis information

                                Biosynthetic modules

                                Name
                                1
                                Type
                                nrps-type1
                                Genes
                                phqB
                                Substrates
                                4S-methylproline (evidence: Structure-based inference)
                                Integrated Monomers
                                Domains
                                condensation (LCL), adenylation
                                Name
                                2
                                Type
                                nrps-type1
                                Genes
                                phqB
                                Substrates
                                tryptophan (evidence: Structure-based inference)
                                Integrated Monomers
                                Domains
                                adenylation
                                Annotation changelog

                                Entry version: next

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2023-11-14
                                Added comment on gene sequence for phqN.
                                • (ID: 4T7Y257BCOAID5IKGPXOVORQ)
                                • (ID: C62OJVVH7XOTOTFZSJT727YU)
                                • (ID: ZF6B6VBOHAZ5KYONQR36C2NB)

                                Entry version: 3

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2022-09-15
                                Add additional reference
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Corrected NRP module activity
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2022-09-15
                                Updated NRP substrate specificities
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 2

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2019-10-16
                                Migrated from v1.4
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                2019-10-16
                                Updated compound(s) information (NPAtlas curation)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                Entry version: 1

                                Date
                                Changes
                                Submitters
                                Reviewers
                                2015-06-12
                                Submitted
                                • (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z)
                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                Detailed domain annotation
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